hyaluronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3957 9004-61-9

Description:

MoleculeDescription

Synonyms:

  • hyaluronate sodium
  • hyaluronic acid
  • hyaluronate
A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.
  • Molecular weight:
  • Formula: (C14H21NO12)n
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3.60 mg P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 432.75 10.51 176 281251 287670 90059350
Acute kidney injury 413.21 10.51 241 281186 320146 90026874
Completed suicide 398.95 10.51 11 281416 145047 90201973
Rheumatoid arthritis 381.57 10.51 2170 279257 360444 89986576
Night sweats 378.95 10.51 1065 280362 127701 90219319
Psoriatic arthropathy 363.17 10.51 1538 279889 226797 90120223
Rheumatic fever 354.44 10.51 1164 280263 151957 90195063
Drug interaction 343.77 10.51 217 281210 276236 90070784
Bursitis 329.41 10.51 1028 280399 130626 90216394
Lip dry 326.97 10.51 865 280562 100090 90246930
Prescribed overdose 316.71 10.51 837 280590 96788 90250232
Fibromyalgia 309.25 10.51 1365 280062 204904 90142116
Peripheral venous disease 287.08 10.51 734 280693 83187 90263833
Temperature regulation disorder 279.21 10.51 282 281145 14297 90332723
Type 2 diabetes mellitus 274.95 10.51 1305 280122 201939 90145081
Liver injury 271.92 10.51 1150 280277 169417 90177603
Food allergy 263.21 10.51 359 281068 25119 90321901
Facet joint syndrome 255.11 10.51 778 280649 97611 90249409
Swollen joint count increased 253.34 10.51 841 280586 110365 90236655
Neutropenia 238.88 10.51 208 281219 224696 90122324
Joint range of motion decreased 235.47 10.51 939 280488 134704 90212316
C-reactive protein abnormal 228.35 10.51 891 280536 126538 90220482
Road traffic accident 227.65 10.51 794 280633 106832 90240188
Urticaria 221.14 10.51 1695 279732 311039 90035981
Deep vein thrombosis postoperative 220.44 10.51 598 280829 70211 90276809
Intentional overdose 217.93 10.51 20 281407 93814 90253206
Cardiac arrest 210.70 10.51 36 281391 104899 90242121
Lower limb fracture 209.97 10.51 661 280766 84352 90262668
Injury 209.82 10.51 1185 280242 196164 90150856
Folliculitis 209.37 10.51 1215 280212 203138 90143882
Immunodeficiency 207.29 10.51 432 280995 42802 90304218
Asthma 206.28 10.51 1373 280054 240787 90106233
Dry mouth 206.22 10.51 1121 280306 182938 90164082
Muscle injury 202.04 10.51 1082 280345 175572 90171448
Duodenal ulcer perforation 199.66 10.51 1273 280154 220015 90127005
Irritable bowel syndrome 198.16 10.51 1211 280216 206237 90140783
Blood cholesterol increased 197.88 10.51 1213 280214 206799 90140221
Gait inability 192.63 10.51 933 280494 145523 90201497
Autoimmune disorder 187.95 10.51 595 280832 76149 90270871
Helicobacter infection 184.11 10.51 1271 280156 225579 90121441
Macular degeneration 180.40 10.51 378 281049 37592 90309428
Impaired healing 177.72 10.51 1291 280136 232908 90114112
Mobility decreased 175.50 10.51 1356 280071 249378 90097642
Renal failure 172.36 10.51 96 281331 130911 90216109
Sleep disorder due to general medical condition, insomnia type 172.22 10.51 824 280603 127870 90219150
Sensitisation 171.25 10.51 125 281302 4050 90342970
Abdominal pain upper 166.37 10.51 1671 279756 331003 90016017
Sciatica 164.94 10.51 688 280739 100694 90246326
Drug ineffective 163.92 10.51 3175 278252 1381123 88965897
Coeliac disease 162.81 10.51 400 281027 44210 90302810
Suicide attempt 162.58 10.51 21 281406 75378 90271642
Pancytopenia 159.85 10.51 87 281340 120176 90226844
Death 159.50 10.51 802 280625 455749 89891271
Wheezing 158.59 10.51 1273 280154 236807 90110213
Obesity 157.80 10.51 698 280729 104809 90242211
Infusion related reaction 154.38 10.51 1974 279453 414806 89932214
Seizure 153.89 10.51 148 281279 152481 90194539
Taste disorder 153.30 10.51 480 280947 61066 90285954
Ill-defined disorder 152.99 10.51 1041 280386 183850 90163170
Stomatitis 152.19 10.51 1410 280017 273288 90073732
Pericarditis 145.82 10.51 1379 280048 268772 90078248
Ear pain 144.62 10.51 451 280976 57251 90289769
Febrile neutropenia 144.56 10.51 167 281260 158182 90188838
Ejection fraction 141.62 10.51 98 281329 2913 90344107
Sleep disorder 140.76 10.51 1075 280352 196955 90150065
Polycystic ovaries 139.90 10.51 126 281301 5528 90341492
Anaemia 137.78 10.51 595 280832 352207 89994813
Hypotension 137.58 10.51 532 280895 324865 90022155
Lung disorder 136.81 10.51 865 280562 149018 90198002
Septic shock 135.51 10.51 46 281381 84114 90262906
Lower respiratory tract infection 135.01 10.51 1279 280148 249380 90097640
Cardiac failure 134.54 10.51 87 281340 109409 90237611
Hepatic enzyme increased 134.13 10.51 1710 279717 359026 89987994
X-ray abnormal 132.82 10.51 375 281052 45049 90301971
Sinusitis 131.68 10.51 1636 279791 341452 90005568
Cardio-respiratory arrest 130.47 10.51 20 281407 63120 90283900
Liver disorder 128.02 10.51 727 280700 120542 90226478
Wound infection 127.96 10.51 661 280766 105741 90241279
C-reactive protein 127.16 10.51 293 281134 31074 90315946
Hypoaesthesia 126.51 10.51 1512 279915 312698 90034322
Musculoskeletal pain 126.41 10.51 938 280489 170313 90176707
Wound 124.20 10.51 1463 279964 301517 90045503
Rheumatoid factor positive 123.77 10.51 935 280492 170715 90176305
Blister 123.16 10.51 1272 280155 253726 90093294
Hypokalaemia 122.16 10.51 136 281291 130980 90216040
Live birth 120.28 10.51 526 280901 78581 90268439
Lupus vulgaris 120.22 10.51 360 281067 44699 90302321
Multiple organ dysfunction syndrome 119.72 10.51 32 281395 68304 90278716
Electrocardiogram QT prolonged 119.48 10.51 38 281389 72418 90274602
Respiratory failure 119.16 10.51 115 281312 118303 90228717
Drug abuse 117.81 10.51 54 281373 82293 90264727
Breast cancer stage III 117.54 10.51 547 280880 83900 90263120
Renal impairment 117.42 10.51 93 281334 105328 90241692
Hyperkalaemia 116.54 10.51 29 281398 64935 90282085
Disease progression 116.04 10.51 192 281235 156423 90190597
Respiratory disorder 115.06 10.51 452 280975 64364 90282656
Sepsis 113.38 10.51 243 281184 179571 90167449
Joint swelling 111.74 10.51 2188 279239 501112 89845908
Hyponatraemia 108.25 10.51 154 281273 133384 90213636
Loss of consciousness 107.59 10.51 168 281259 140070 90206950
Bradycardia 106.63 10.51 64 281363 83783 90263237
Blepharospasm 105.26 10.51 395 281032 55050 90291970
Muscle spasticity 103.65 10.51 292 281135 35030 90311990
Pulmonary embolism 102.00 10.51 155 281272 130665 90216355
Rhabdomyolysis 101.97 10.51 18 281409 51238 90295782
Angioedema 101.80 10.51 37 281390 64839 90282181
Gastrooesophageal reflux disease 101.39 10.51 872 280555 165465 90181555
Peripheral swelling 100.28 10.51 1821 279606 411285 89935735
Metabolic acidosis 99.58 10.51 25 281402 55651 90291369
Ulcer haemorrhage 99.22 10.51 239 281188 26082 90320938
Myocardial infarction 98.62 10.51 110 281317 105862 90241158
Lactic acidosis 97.65 10.51 19 281408 50444 90296576
Inflammation 96.46 10.51 912 280515 177680 90169340
Weight increased 95.81 10.51 1826 279601 416101 89930919
Malignant neoplasm progression 95.07 10.51 115 281312 106755 90240265
Hypoglycaemia 95.06 10.51 49 281378 69799 90277221
Osteoarthritis 93.82 10.51 975 280452 194755 90152265
Syncope 92.48 10.51 169 281258 132494 90214526
Dehydration 91.36 10.51 304 281123 194143 90152877
Hand deformity 89.06 10.51 1353 280074 295009 90052011
Onychomadesis 86.74 10.51 327 281100 45671 90301349
Nasopharyngitis 86.32 10.51 1758 279669 405346 89941674
Interstitial lung disease 85.59 10.51 67 281360 76338 90270682
Glossodynia 85.41 10.51 1439 279988 320340 90026680
Chronic sinusitis 85.33 10.51 212 281215 23590 90323430
Mucosal inflammation 85.25 10.51 36 281391 57589 90289431
Intentional product use issue 85.17 10.51 1039 280388 215853 90131167
Drug reaction with eosinophilia and systemic symptoms 85.09 10.51 15 281412 42743 90304277
Alanine aminotransferase increased 84.96 10.51 148 281279 118190 90228830
Encephalopathy 84.74 10.51 20 281407 46424 90300596
Cholestasis 83.58 10.51 8 281419 36291 90310729
Fluid retention 82.60 10.51 512 280915 87579 90259441
Hypertension 81.82 10.51 1928 279499 455604 89891416
Hypercholesterolaemia 81.58 10.51 565 280862 100327 90246693
Foetal exposure during pregnancy 81.45 10.51 17 281410 42958 90304062
Pemphigus 80.02 10.51 1443 279984 325421 90021599
Insomnia 79.48 10.51 1466 279961 332008 90015012
Suicidal ideation 78.72 10.51 68 281359 73787 90273233
Intentional self-injury 77.86 10.51 3 281424 29331 90317689
Upper respiratory tract infection 77.81 10.51 672 280755 127646 90219374
Anti-cyclic citrullinated peptide antibody positive 77.54 10.51 1096 280331 235337 90111683
Rash erythematous 77.25 10.51 403 281024 64701 90282319
Dyspepsia 77.24 10.51 948 280479 197212 90149808
Hypoxia 76.75 10.51 67 281360 72332 90274688
Frequent bowel movements 76.44 10.51 365 281062 56570 90290450
Hepatic cytolysis 76.24 10.51 5 281422 30911 90316109
Gastrointestinal disorder 75.61 10.51 1168 280259 255519 90091501
Synovitis 75.25 10.51 1440 279987 328312 90018708
Muscle spasms 74.90 10.51 1148 280279 250735 90096285
Ejection fraction abnormal 72.71 10.51 61 281366 2430 90344590
Serotonin syndrome 71.77 10.51 15 281412 37872 90309148
Adverse event 71.24 10.51 615 280812 116803 90230217
Hepatocellular injury 70.49 10.51 5 281422 28953 90318067
Liver function test abnormal 70.19 10.51 35 281392 50810 90296210
Treatment failure 69.95 10.51 1329 280098 302599 90044421
Blood creatinine increased 69.91 10.51 130 281297 101256 90245764
Vaginal flatulence 69.82 10.51 134 281293 12504 90334516
Retinitis 69.72 10.51 270 281157 38188 90308832
Dislocation of vertebra 69.57 10.51 351 281076 55617 90291403
Grip strength decreased 69.36 10.51 509 280918 92067 90254953
Adjustment disorder with depressed mood 69.20 10.51 354 281073 56399 90290621
Cough 69.18 10.51 772 280655 368190 89978830
Product quality issue 68.78 10.51 452 280975 78873 90268147
Rhinitis allergic 68.26 10.51 157 281270 16628 90330392
Breast cancer stage II 68.13 10.51 253 281174 35081 90311939
Cardiac failure congestive 67.65 10.51 127 281300 98567 90248453
Sleep disorder due to a general medical condition 67.63 10.51 297 281130 44441 90302579
Contraindicated product administered 66.67 10.51 1379 280048 318760 90028260
Myelosuppression 66.62 10.51 42 281385 53549 90293471
Migraine 66.24 10.51 892 280535 189500 90157520
Memory impairment 66.13 10.51 918 280509 196326 90150694
Maternal exposure timing unspecified 66.10 10.51 186 281241 22297 90324723
Transaminases increased 65.94 10.51 17 281410 37175 90309845
Aspartate aminotransferase increased 65.79 10.51 138 281289 102799 90244221
Foetal death 65.45 10.51 176 281251 20547 90326473
Anaphylactic reaction 65.09 10.51 107 281320 87417 90259603
Therapy non-responder 65.02 10.51 680 280747 136024 90210996
Body temperature increased 64.71 10.51 293 281134 44417 90302603
Ventricular tachycardia 64.01 10.51 3 281424 24705 90322315
Eosinophilia 63.85 10.51 7 281420 28526 90318494
Atrial fibrillation 62.66 10.51 209 281218 133402 90213618
Disorientation 61.45 10.51 30 281397 44084 90302936
Nephrectomy 60.92 10.51 50 281377 1931 90345089
Carpal tunnel syndrome 60.84 10.51 188 281239 23740 90323280
Tachycardia 60.20 10.51 268 281159 157405 90189615
Agranulocytosis 60.17 10.51 17 281410 34985 90312035
Somnolence 59.59 10.51 392 281035 208692 90138328
Oedema 58.80 10.51 911 280516 199384 90147636
Bone marrow failure 58.54 10.51 14 281413 32207 90314813
Pleural effusion 58.32 10.51 167 281260 111824 90235196
Device expulsion 58.18 10.51 27 281400 40859 90306161
Nausea 57.70 10.51 2840 278587 1107476 89239544
Blood test abnormal 57.40 10.51 169 281258 20783 90326237
Laryngitis 57.36 10.51 310 281117 50443 90296577
Abortion spontaneous 57.33 10.51 50 281377 54006 90293014
Hepatic failure 56.90 10.51 26 281401 39702 90307318
Rash maculo-papular 56.77 10.51 28 281399 40905 90306115
Cerebrovascular accident 56.73 10.51 195 281232 123338 90223682
Premature baby 56.50 10.51 6 281421 25071 90321949
Systemic lupus erythematosus 56.31 10.51 1497 279930 360399 89986621
Anti-cyclic citrullinated peptide antibody 55.94 10.51 199 281228 27022 90319998
Contusion 55.90 10.51 1093 280334 250123 90096897
Hypersensitivity 55.32 10.51 1824 279603 452853 89894167
Deep vein thrombosis 55.12 10.51 127 281300 91493 90255527
Proctitis 54.79 10.51 136 281291 15123 90331897
Cardiogenic shock 54.76 10.51 6 281421 24462 90322558
Hallucination 54.50 10.51 75 281352 65884 90281136
Pneumonia 54.39 10.51 1537 279890 636522 89710498
Hypocalcaemia 54.34 10.51 32 281395 42336 90304684
Psychotic disorder 53.99 10.51 15 281412 31215 90315805
International normalised ratio increased 53.62 10.51 41 281386 47275 90299745
Sedation complication 53.61 10.51 144 281283 16800 90330220
Pulmonary fibrosis 53.13 10.51 539 280888 106964 90240056
Premature delivery 53.03 10.51 27 281400 38735 90308285
Unresponsive to stimuli 52.98 10.51 26 281401 38095 90308925
Tremor 52.83 10.51 270 281157 152903 90194117
Exostosis 52.44 10.51 313 281114 52821 90294199
Tubulointerstitial nephritis 52.42 10.51 8 281419 25335 90321685
Product use issue 52.26 10.51 1368 280059 328551 90018469
Nail disorder 52.07 10.51 338 281089 58729 90288291
Paraesthesia 51.67 10.51 1077 280350 249249 90097771
Hepatotoxicity 51.59 10.51 40 281387 45802 90301218
Deafness transitory 51.48 10.51 46 281381 1997 90345023
Headache 51.42 10.51 3218 278209 859528 89487492
Cytokine release syndrome 51.12 10.51 12 281415 27961 90319059
Leukopenia 51.12 10.51 152 281275 100558 90246462
Ischaemic stroke 50.73 10.51 5 281422 22161 90324859
Diabetes mellitus 49.47 10.51 78 281349 64797 90282223
Cytomegalovirus infection 49.44 10.51 11 281416 26591 90320429
Urinary retention 49.13 10.51 28 281399 37716 90309304
Drug dependence 49.03 10.51 15 281412 29312 90317708
Hypomagnesaemia 48.37 10.51 25 281402 35563 90311457
Generalised tonic-clonic seizure 48.21 10.51 24 281403 34879 90312141
Agitation 48.08 10.51 84 281343 67014 90280006
No adverse event 47.90 10.51 86 281341 67896 90279124
Hepatic function abnormal 47.67 10.51 44 281383 46244 90300776
Hyperglycaemia 47.31 10.51 53 281374 50917 90296103
Colitis ulcerative 47.24 10.51 335 281092 59931 90287089
Pulmonary oedema 47.00 10.51 75 281352 62005 90285015
Creatinine renal clearance decreased 46.68 10.51 147 281280 18752 90328268
Oxygen saturation decreased 46.47 10.51 174 281253 107309 90239711
Female genital tract fistula 46.00 10.51 141 281286 17727 90329293
Respiratory arrest 45.87 10.51 23 281404 33288 90313732
Toxic anterior segment syndrome 45.81 10.51 45 281382 2205 90344815
Subcutaneous drug absorption impaired 45.80 10.51 118 281309 13427 90333593
Hepatic cirrhosis 45.80 10.51 345 281082 62908 90284112
Back injury 45.60 10.51 274 281153 46348 90300672
Dyspnoea 45.35 10.51 2255 279172 878700 89468320
Arthropathy 45.23 10.51 1472 279955 364770 89982250
Respiratory distress 45.09 10.51 33 281394 38913 90308107
Musculoskeletal stiffness 45.07 10.51 1223 280204 295309 90051711
Paraesthesia oral 44.72 10.51 206 281221 31453 90315567
Swollen tongue 44.64 10.51 46 281381 45910 90301110
Altered state of consciousness 44.60 10.51 21 281406 31511 90315509
Therapeutic product effect incomplete 44.27 10.51 847 280580 193049 90153971
Mental status changes 44.23 10.51 44 281383 44635 90302385
Bone erosion 44.08 10.51 299 281128 52722 90294298
Palpitations 43.83 10.51 247 281180 136481 90210539
Melaena 43.62 10.51 27 281400 34770 90312250
Swelling 43.49 10.51 1651 279776 417407 89929613
Inappropriate antidiuretic hormone secretion 43.10 10.51 5 281422 19500 90327520
Circulatory collapse 42.98 10.51 12 281415 24892 90322128
Metastases to liver 42.60 10.51 18 281409 28789 90318231
Prescribed underdose 42.43 10.51 387 281040 74632 90272388
Vaginal discharge 42.34 10.51 145 281282 19319 90327701
Drug eruption 42.31 10.51 29 281398 35378 90311642
Dysphagia 42.15 10.51 192 281235 112086 90234934
Radiculopathy 42.15 10.51 140 281287 18365 90328655
Pneumocystis jirovecii pneumonia 42.11 10.51 8 281419 21608 90325412
Cholelithiasis 42.09 10.51 61 281366 52445 90294575
Dysarthria 42.02 10.51 65 281362 54417 90292603
Posterior reversible encephalopathy syndrome 42.00 10.51 9 281418 22330 90324690
Anaphylactic shock 41.81 10.51 23 281404 31594 90315426
Epilepsy 41.02 10.51 413 281014 81793 90265227
Blood pressure decreased 40.99 10.51 109 281318 74786 90272234
Shock 40.96 10.51 19 281408 28759 90318261
Lupus-like syndrome 40.93 10.51 276 281151 48570 90298450
Coronary artery disease 40.90 10.51 27 281400 33596 90313424
Acute respiratory distress syndrome 40.73 10.51 19 281408 28667 90318353
Sinus tachycardia 40.31 10.51 19 281408 28494 90318526
Drug level increased 40.02 10.51 18 281409 27744 90319276
Dyskinesia 39.71 10.51 33 281394 36501 90310519
Myalgia 39.64 10.51 350 281077 174775 90172245
Blood bilirubin increased 39.48 10.51 46 281381 43424 90303596
Stevens-Johnson syndrome 39.39 10.51 21 281406 29355 90317665
Gastrointestinal haemorrhage 39.08 10.51 146 281281 90102 90256918
Lupus vasculitis 38.91 10.51 24 281403 584 90346436
Acute hepatic failure 38.70 10.51 11 281416 22550 90324470
Urinary tract infection 38.59 10.51 692 280735 304940 90042080
Eye injury 38.29 10.51 97 281330 10923 90336097
Rheumatoid nodule 38.17 10.51 8 281419 20158 90326862
Fall 37.91 10.51 1173 280254 480637 89866383
Ascites 37.74 10.51 56 281371 47684 90299336
Metastases to bone 37.62 10.51 16 281411 25489 90321531
Toxic skin eruption 37.61 10.51 3 281424 15771 90331249
Myoclonus 37.54 10.51 7 281420 19161 90327859
Constipation 37.23 10.51 1137 280290 279258 90067762
Arrhythmia 37.17 10.51 46 281381 42286 90304734
Poisoning deliberate 37 10.51 4 281423 16482 90330538
Haematoma 36.91 10.51 40 281387 39008 90308012
Discomfort 36.85 10.51 1114 280313 273221 90073799
Poisoning 35.99 10.51 3 281424 15214 90331806
Polyneuropathy 35.94 10.51 8 281419 19333 90327687
Aggression 35.85 10.51 19 281408 26649 90320371
Onychomycosis 35.50 10.51 218 281209 37158 90309862
Haematuria 35.05 10.51 34 281393 34903 90312117
Drug resistance 34.99 10.51 26 281401 30423 90316597
Status epilepticus 34.68 10.51 8 281419 18866 90328154
Drug ineffective for unapproved indication 34.24 10.51 100 281327 66544 90280476
Pneumonitis 33.78 10.51 53 281374 44117 90302903
Hypercalcaemia 33.57 10.51 34 281393 34206 90312814
Pain 33.43 10.51 3557 277870 992784 89354236
Jaundice 33.38 10.51 31 281396 32486 90314534
Blood creatine phosphokinase increased 33.11 10.51 34 281393 33989 90313031
Lymphadenopathy 33.07 10.51 57 281370 45718 90301302
Body tinea 33.06 10.51 37 281390 2111 90344909
Pregnancy 33.04 10.51 316 281111 61731 90285289
Infection 32.78 10.51 1406 280021 360688 89986332
Osteonecrosis of jaw 32.77 10.51 44 281383 39059 90307961
General symptom 32.54 10.51 110 281317 14558 90332462
Therapy partial responder 32.24 10.51 14 281413 22029 90324991
Toxic epidermal necrolysis 32.23 10.51 32 281395 32496 90314524
Osteonecrosis 32.02 10.51 21 281406 26220 90320800
Sleep apnoea syndrome 31.96 10.51 188 281239 31559 90315461
Blood pressure systolic increased 31.86 10.51 85 281342 58260 90288760
Drug hypersensitivity 31.85 10.51 1752 279675 461857 89885163
Hallucination, visual 31.71 10.51 16 281411 23076 90323944
Pulmonary hypertension 31.60 10.51 52 281375 42471 90304549
Hypocholesterolaemia 31.56 10.51 65 281362 6384 90340636
Tenosynovitis 31.54 10.51 4 281423 14563 90332457
Skin necrosis 31.49 10.51 7 281420 16934 90330086
Panniculitis 31.23 10.51 4 281423 14454 90332566
Pallor 31.19 10.51 36 281391 34129 90312891
Dystonia 31.16 10.51 7 281420 16812 90330208
Disseminated intravascular coagulation 30.99 10.51 14 281413 21524 90325496
Neurotoxicity 30.82 10.51 14 281413 21453 90325567
Muscle rigidity 30.81 10.51 4 281423 14305 90332715
Porphyria acute 30.80 10.51 124 281303 17851 90329169
Neutropenic sepsis 30.80 10.51 9 281418 18121 90328899
Neuroleptic malignant syndrome 30.69 10.51 5 281422 15091 90331929
Diabetic ketoacidosis 30.51 10.51 19 281408 24388 90322632
Caesarean section 30.17 10.51 10 281417 18567 90328453
Ventricular fibrillation 30.06 10.51 4 281423 14040 90332980
Rash vesicular 29.97 10.51 124 281303 18073 90328947
Bronchiectasis 29.88 10.51 16 281411 22314 90324706
Chronic kidney disease 29.84 10.51 70 281357 50121 90296899
Vaginal haemorrhage 29.59 10.51 32 281395 31239 90315781
Sinus bradycardia 29.57 10.51 8 281419 16944 90330076
Gamma-glutamyltransferase increased 29.54 10.51 45 281382 37907 90309113
Dyspnoea exertional 29.34 10.51 120 281307 72168 90274852
Labelled drug-drug interaction medication error 29.27 10.51 5 281422 14577 90332443
Creatinine renal clearance increased 29.11 10.51 43 281384 3238 90343782
Tachypnoea 28.91 10.51 15 281412 21294 90325726
Acute myeloid leukaemia 28.80 10.51 14 281413 20626 90326394
Ataxia 28.80 10.51 10 281417 18032 90328988
Blood calcium decreased 28.64 10.51 176 281251 30006 90317014
Psoriasis 28.62 10.51 630 280797 147124 90199896
Acute myocardial infarction 28.50 10.51 40 281387 34850 90312170
Pericardial effusion 28.35 10.51 44 281383 36789 90310231
Thrombotic microangiopathy 28.28 10.51 7 281420 15736 90331284
Haematotoxicity 28.24 10.51 3 281424 12532 90334488
Extrapyramidal disorder 27.87 10.51 8 281419 16295 90330725
Incorrect dose administered 27.85 10.51 138 281289 78792 90268228
Anuria 27.79 10.51 6 281421 14812 90332208
Cardiomyopathy 27.75 10.51 14 281413 20192 90326828
Infusion site reaction 27.72 10.51 125 281302 18914 90328106
Chest discomfort 27.70 10.51 285 281142 138080 90208940
Procedural pain 27.65 10.51 188 281239 33172 90313848
Drug withdrawal syndrome 27.62 10.51 29 281398 28694 90318326
Tendonitis 27.61 10.51 16 281411 21356 90325664
Basal cell carcinoma 27.55 10.51 38 281389 33351 90313669
Haematemesis 27.21 10.51 39 281388 33687 90313333
Incorrect route of product administration 27.04 10.51 258 281169 50368 90296652
Mouth ulceration 26.90 10.51 52 281375 39922 90307098
Staphylococcal infection 26.88 10.51 70 281357 48369 90298651
Acute generalised exanthematous pustulosis 26.85 10.51 5 281422 13698 90333322
Right ventricular failure 26.84 10.51 13 281414 19192 90327828
Swollen joint count 26.83 10.51 73 281354 8580 90338440
Ear infection 26.81 10.51 333 281094 69442 90277578
Decreased appetite 26.64 10.51 1427 280000 375113 89971907
Peritonitis 26.55 10.51 14 281413 19691 90327329
Overlap syndrome 26.39 10.51 72 281355 8476 90338544
Keratopathy 26.36 10.51 20 281407 688 90346332
Angina pectoris 26.30 10.51 51 281376 39109 90307911
Infection susceptibility increased 25.96 10.51 45 281382 3881 90343139
Premature labour 25.95 10.51 5 281422 13371 90333649
Product use in unapproved indication 25.76 10.51 1284 280143 334952 90012068
Aplastic anaemia 25.66 10.51 5 281422 13264 90333756
Accidental overdose 25.59 10.51 30 281397 28243 90318777
Diabetes mellitus inadequate control 25.58 10.51 13 281414 18671 90328349
Nervous system disorder 25.39 10.51 18 281409 21575 90325445
Thrombocytopenia 25.26 10.51 476 280951 208249 90138771
Abnormal behaviour 25.14 10.51 20 281407 22608 90324412
Blood lactate dehydrogenase increased 25.14 10.51 26 281401 25906 90321114
Myelodysplastic syndrome 25.14 10.51 17 281410 20886 90326134
Multiple fractures 25.12 10.51 76 281351 9486 90337534
Skin ulcer 25.10 10.51 76 281351 49999 90297021
Device dislocation 24.82 10.51 37 281390 31445 90315575
Disturbance in attention 24.70 10.51 70 281357 47039 90299981
Gastroenteritis 24.38 10.51 33 281394 29196 90317824
Akathisia 24.31 10.51 3 281424 11156 90335864
Cerebral infarction 24.31 10.51 28 281399 26568 90320452
Influenza 24.27 10.51 296 281131 138968 90208052
Cardiovascular disorder 24.24 10.51 6 281421 13486 90333534
Pustular psoriasis 24.21 10.51 118 281309 18438 90328582
General physical health deterioration 24.17 10.51 1341 280086 353774 89993246
Vasculitis 24.05 10.51 21 281406 22672 90324348
Hepatic steatosis 24.05 10.51 49 281378 36896 90310124
Blood glucose increased 23.98 10.51 185 281242 95061 90251959
Product substitution issue 23.96 10.51 13 281414 17995 90329025
Subarachnoid haemorrhage 23.71 10.51 13 281414 17891 90329129
Tuberculosis 23.70 10.51 5 281422 12544 90334476
Hallucination, auditory 23.59 10.51 10 281417 15965 90331055
Exposure during pregnancy 23.44 10.51 934 280493 237476 90109544
Coma 23.39 10.51 131 281296 72501 90274519
Cardiomegaly 23.29 10.51 15 281412 18910 90328110
Myocardial ischaemia 23.21 10.51 7 281420 13807 90333213
Cyanosis 23.16 10.51 16 281411 19439 90327581
Complication associated with device 23.15 10.51 16 281411 19433 90327587
Abdominal discomfort 23.14 10.51 1751 279676 475577 89871443
Face oedema 23.04 10.51 23 281404 23295 90323725
Cardiac murmur 22.97 10.51 14 281413 18180 90328840
Granuloma skin 22.96 10.51 3 281424 10677 90336343
Gastric ulcer 22.89 10.51 31 281396 27417 90319603
Device difficult to use 22.81 10.51 13 281414 17512 90329508
Adrenal insufficiency 22.79 10.51 36 281391 29885 90317135
Device malfunction 22.73 10.51 19 281408 20958 90326062
Mental disorder 22.66 10.51 41 281386 32277 90314743
Renal function test abnormal 22.63 10.51 61 281366 7130 90339890
Schizophrenia 22.57 10.51 9 281418 14905 90332115
Hip arthroplasty 22.49 10.51 347 281080 75861 90271159
Functional gastrointestinal disorder 22.43 10.51 49 281378 5013 90342007
Vertigo 22.43 10.51 126 281301 69685 90277335
Haemorrhage 22.40 10.51 125 281302 69244 90277776
Cerebral haemorrhage 22.29 10.51 46 281381 34476 90312544
Pyelonephritis 22.26 10.51 20 281407 21296 90325724
Gastrointestinal pain 22.24 10.51 81 281346 11125 90335895
Metastases to lung 22.08 10.51 11 281416 15980 90331040
Hypertensive crisis 22.02 10.51 14 281413 17770 90329250
Epstein-Barr virus infection 22.01 10.51 3 281424 10341 90336679
Heart rate increased 22.01 10.51 234 281193 112668 90234352
Proteinuria 21.85 10.51 24 281403 23267 90323753
Drug-induced liver injury 21.79 10.51 398 281029 89920 90257100
Renal tubular necrosis 21.68 10.51 9 281418 14546 90332474
Haemorrhage intracranial 21.59 10.51 10 281417 15152 90331868
Mydriasis 21.23 10.51 10 281417 15002 90332018
Jaundice cholestatic 21.16 10.51 3 281424 10040 90336980
Dermatitis atopic 21.10 10.51 135 281292 23337 90323683
Nail bed inflammation 21.10 10.51 27 281400 1774 90345246
Aspergillus infection 21.10 10.51 4 281423 10819 90336201
Palmar-plantar erythrodysaesthesia syndrome 21.07 10.51 34 281393 27989 90319031
Disability 20.95 10.51 206 281221 40539 90306481
Product administration error 20.88 10.51 31 281396 26392 90320628
Underdose 20.84 10.51 258 281169 53759 90293261
Coagulopathy 20.77 10.51 25 281402 23264 90323756
Bronchopulmonary aspergillosis 20.61 10.51 5 281422 11393 90335627
Product prescribing error 20.47 10.51 39 281388 30106 90316914
Escherichia infection 20.39 10.51 12 281415 15883 90331137
Stress cardiomyopathy 20.31 10.51 8 281419 13347 90333673
Neuropathy peripheral 20.29 10.51 301 281126 136669 90210351
Leukocytosis 20.26 10.51 41 281386 30949 90316071
Ulcer 20.24 10.51 45 281382 32837 90314183
Haemoptysis 20.19 10.51 46 281381 33274 90313746
Stoma site dermatitis 20.13 10.51 12 281415 274 90346746
Hemiparesis 20.04 10.51 43 281384 31776 90315244
Flushing 19.95 10.51 177 281250 88314 90258706
Intentional product misuse 19.95 10.51 390 281037 89214 90257806
Chills 19.91 10.51 289 281138 131692 90215328
Progressive multifocal leukoencephalopathy 19.83 10.51 12 281415 15643 90331377
Adverse reaction 19.81 10.51 159 281268 29553 90317467
Ankylosing spondylitis 19.75 10.51 8 281419 13125 90333895
Treatment noncompliance 19.68 10.51 88 281339 51639 90295381
Oral candidiasis 19.59 10.51 182 281245 35273 90311747
Transient ischaemic attack 19.25 10.51 69 281358 43107 90303913
Myopathy 19.12 10.51 9 281418 13509 90333511
Pulmonary toxicity 19.09 10.51 6 281421 11525 90335495
Mania 19.08 10.51 10 281417 14114 90332906
Lung infiltration 18.96 10.51 12 281415 15270 90331750
Nasal mucosal disorder 18.92 10.51 26 281401 1831 90345189
Acute respiratory failure 18.86 10.51 69 281358 42849 90304171
Blood pressure increased 18.86 10.51 467 280960 196750 90150270
C-reactive protein increased 18.86 10.51 715 280712 180674 90166346
Adverse drug reaction 18.76 10.51 485 280942 116216 90230804
Accidental exposure to product 18.69 10.51 68 281359 42298 90304722
Swelling face 18.66 10.51 162 281265 81190 90265830
Nephropathy toxic 18.65 10.51 8 281419 12680 90334340
Pain in jaw 18.64 10.51 81 281346 47904 90299116
Epistaxis 18.44 10.51 172 281255 84953 90262067
Presyncope 18.40 10.51 45 281382 31760 90315260
Obstructive defaecation 18.15 10.51 11 281416 259 90346761
Pancreatitis acute 18.14 10.51 46 281381 32069 90314951
Subdural haematoma 18.13 10.51 15 281412 16630 90330390
Faecaloma 18.05 10.51 5 281422 10426 90336594
Inhibitory drug interaction 18.04 10.51 34 281393 3129 90343891
Decreased immune responsiveness 18.01 10.51 64 281363 8684 90338336
Atelectasis 18.00 10.51 30 281397 24379 90322641
Obstructive airways disorder 17.98 10.51 33 281394 25836 90321184
Hydronephrosis 17.94 10.51 8 281419 12394 90334626
Crepitations 17.84 10.51 3 281424 8849 90338171
Haemolytic anaemia 17.80 10.51 7 281420 11690 90335330
Gastritis 17.78 10.51 68 281359 41685 90305335
Acute pulmonary oedema 17.72 10.51 4 281423 9576 90337444
Lethargy 17.66 10.51 119 281308 63020 90284000
Renal injury 17.56 10.51 5 281422 10238 90336782
Shock haemorrhagic 17.56 10.51 8 281419 12237 90334783
Genital haemorrhage 17.43 10.51 3 281424 8699 90338321
Psychomotor hyperactivity 17.41 10.51 9 281418 12804 90334216
Breast cancer 17.29 10.51 97 281330 53664 90293356
Acute coronary syndrome 17.25 10.51 6 281421 10807 90336213
Osteomyelitis 17.23 10.51 38 281389 27808 90319212
Sputum discoloured 17.03 10.51 23 281404 20368 90326652
Haemoglobin decreased 17.02 10.51 378 281049 161578 90185442
Hypervolaemia 16.94 10.51 49 281378 32708 90314312
Atrioventricular block first degree 16.90 10.51 3 281424 8508 90338512
Pulmonary arterial hypertension 16.82 10.51 35 281392 26152 90320868
Antinuclear antibody positive 16.82 10.51 4 281423 9237 90337783
Blood immunoglobulin M increased 16.76 10.51 21 281406 1351 90345669
Joint effusion 16.70 10.51 22 281405 19688 90327332
Cestode infection 16.63 10.51 11 281416 303 90346717
Breath sounds abnormal 16.60 10.51 14 281413 15372 90331648
Atrioventricular block complete 16.43 10.51 5 281422 9806 90337214
Pleuritic pain 16.35 10.51 6 281421 10455 90336565
Aphasia 16.19 10.51 73 281354 42739 90304281
Weight fluctuation 16.19 10.51 111 281316 19638 90327382
Injection site erythema 16.17 10.51 212 281215 98290 90248730
Blood urea increased 16.09 10.51 45 281382 30368 90316652
Clostridium difficile colitis 16.07 10.51 37 281390 26669 90320351
Erythema multiforme 16.06 10.51 9 281418 12237 90334783
Pulseless electrical activity 15.99 10.51 4 281423 8928 90338092
Gastrointestinal stoma output abnormal 15.94 10.51 12 281415 408 90346612
Tardive dyskinesia 15.89 10.51 7 281420 10923 90336097
Injection site pain 15.88 10.51 414 281013 173285 90173735
Pruritus 15.86 10.51 1917 279510 539608 89807412
Gastric disorder 15.80 10.51 52 281375 33332 90313688
Rectal haemorrhage 15.76 10.51 352 281075 82392 90264628
Renal disorder 15.55 10.51 183 281244 37676 90309344
Platelet count decreased 15.46 10.51 316 281111 136653 90210367
Withdrawal syndrome 15.42 10.51 29 281398 22495 90324525
Apnoea 15.41 10.51 5 281422 9409 90337611
Bacterial infection 15.34 10.51 31 281396 23413 90323607
Diffuse large B-cell lymphoma 15.23 10.51 4 281423 8641 90338379
Enterococcal infection 15.17 10.51 6 281421 9985 90337035
Hypovolaemia 15.10 10.51 10 281417 12421 90334599
Product label confusion 15.08 10.51 122 281305 22728 90324292
Spinal pain 15.07 10.51 16 281411 15751 90331269
Gestational diabetes 15.04 10.51 7 281420 10575 90336445
Electrolyte imbalance 15.03 10.51 32 281395 23713 90323307
Disease recurrence 14.97 10.51 63 281364 37590 90309430
Fear of injection 14.89 10.51 4 281423 8511 90338509
Back disorder 14.88 10.51 133 281294 25498 90321522
Rash 14.88 10.51 2747 278680 793353 89553667
Encephalitis 14.87 10.51 8 281419 11126 90335894
Nasal obstruction 14.80 10.51 28 281399 2584 90344436
Bronchospasm 14.77 10.51 26 281401 20683 90326337
Flank pain 14.76 10.51 23 281404 19199 90327821
Device issue 14.68 10.51 45 281382 29492 90317528
Pre-eclampsia 14.66 10.51 8 281419 11040 90335980
Wrong product administered 14.59 10.51 3 281424 7662 90339358
Hepatomegaly 14.53 10.51 12 281415 13314 90333706
Unintended pregnancy 14.51 10.51 3 281424 7634 90339386
Ileus 14.50 10.51 18 281409 16528 90330492
Nephrolithiasis 14.49 10.51 91 281336 48994 90298026
Myocarditis 14.36 10.51 13 281414 13793 90333227
Dysphonia 14.30 10.51 126 281301 62958 90284062
Injection site pruritus 14.30 10.51 103 281324 53731 90293289
Cytopenia 14.25 10.51 20 281407 17429 90329591
Atrial septal defect 14.15 10.51 4 281423 8230 90338790
Blood immunoglobulin A decreased 14.14 10.51 22 281405 1734 90345286
Intestinal ischaemia 14.05 10.51 5 281422 8878 90338142
Neutrophil count decreased 14.04 10.51 148 281279 71384 90275636
Dermatitis allergic 14.02 10.51 20 281407 17307 90329713
Myositis 13.91 10.51 125 281302 24003 90323017
Gastrointestinal toxicity 13.86 10.51 6 281421 9461 90337559
Biliary tract infection 13.79 10.51 15 281412 829 90346191
Blood lactic acid increased 13.78 10.51 5 281422 8773 90338247
Blood sodium decreased 13.77 10.51 42 281385 27571 90319449
Sarcoidosis 13.77 10.51 8 281419 10665 90336355
Lichen sclerosus 13.76 10.51 19 281408 1344 90345676
Fracture 13.76 10.51 30 281397 22046 90324974
Electrocardiogram QRS complex prolonged 13.73 10.51 3 281424 7345 90339675
Device breakage 13.71 10.51 14 281413 14030 90332990
Paranoia 13.61 10.51 12 281415 12896 90334124
Partial seizures 13.49 10.51 3 281424 7257 90339763
Hyperbilirubinaemia 13.48 10.51 14 281413 13922 90333098
Walking aid user 13.44 10.51 169 281258 35337 90311683
Peripheral sensory neuropathy 13.33 10.51 6 281421 9244 90337776
Blood potassium decreased 13.32 10.51 90 281337 47637 90299383
Pulmonary congestion 13.32 10.51 25 281402 19408 90327612
Acidosis 13.24 10.51 12 281415 12724 90334296
Knee arthroplasty 13.16 10.51 345 281082 82837 90264183
Bone disorder 13.15 10.51 33 281394 23087 90323933
Cushingoid 13.12 10.51 8 281419 10387 90336633
Hypovolaemic shock 13.05 10.51 3 281424 7091 90339929
Hyperthyroidism 13.04 10.51 23 281404 18287 90328733
Inappropriate schedule of product administration 13.02 10.51 360 281067 149573 90197447
Abdominal pain lower 12.94 10.51 49 281378 30128 90316892
Chronic obstructive pulmonary disease 12.83 10.51 157 281270 73672 90273348
Hypotonia 12.82 10.51 10 281417 11416 90335604
Cholangitis infective 12.78 10.51 11 281416 454 90346566
Congenital neuropathy 12.72 10.51 4 281423 16 90347004
Dysuria 12.72 10.51 71 281356 39330 90307690
Brow ptosis 12.69 10.51 10 281417 364 90346656
Gonorrhoea 12.66 10.51 7 281420 138 90346882
Movement disorder 12.52 10.51 47 281380 28972 90318048
Abdominal pain 12.52 10.51 1058 280369 394663 89952357
Alopecia 12.51 10.51 1737 279690 493334 89853686
Cholecystitis 12.51 10.51 21 281406 17019 90330001
Fumbling 12.48 10.51 7 281420 142 90346878
Laryngeal oedema 12.48 10.51 3 281424 6878 90340142
Emotional distress 12.42 10.51 65 281362 36597 90310423
Low birth weight baby 12.35 10.51 7 281420 9460 90337560
Ejection fraction decreased 12.35 10.51 41 281386 26212 90320808
Intracranial pressure increased 12.29 10.51 3 281424 6808 90340212
Thinking abnormal 12.26 10.51 11 281416 11721 90335299
Tumour lysis syndrome 12.21 10.51 10 281417 11142 90335878
Skin toxicity 12.21 10.51 3 281424 6776 90340244
Staphylococcal sepsis 12.16 10.51 7 281420 9376 90337644
Foetal growth restriction 12.15 10.51 7 281420 9373 90337647
Wrong technique in product usage process 12.13 10.51 153 281274 71418 90275602
Neoplasm malignant 12.09 10.51 59 281368 33821 90313199
Tricuspid valve incompetence 11.93 10.51 21 281406 16710 90330310
Device occlusion 11.92 10.51 7 281420 9275 90337745
Congestive cardiomyopathy 11.87 10.51 4 281423 7350 90339670
Streptococcal infection 11.82 10.51 4 281423 7329 90339691
Cardiac disorder 11.81 10.51 245 281182 56627 90290393
Finger deformity 11.79 10.51 155 281272 32742 90314278
Personality change 11.78 10.51 4 281423 7317 90339703
Lymphoma 11.69 10.51 15 281412 13576 90333444
Autoimmune hepatitis 11.69 10.51 9 281418 10342 90336678
Klebsiella infection 11.57 10.51 9 281418 10288 90336732
Arteriosclerosis 11.55 10.51 10 281417 10843 90336177
Device use error 11.53 10.51 4 281423 7217 90339803
Red blood cell sedimentation rate increased 11.50 10.51 337 281090 82258 90264762
Therapeutic product effect decreased 11.46 10.51 1006 280421 276565 90070455
Sleep disorder due to general medical condition, hypersomnia type 11.43 10.51 22 281405 2057 90344963
Femoral neck fracture 11.42 10.51 9 281418 10224 90336796
Upper gastrointestinal haemorrhage 11.42 10.51 35 281392 22941 90324079
Drug dose omission by device 11.42 10.51 9 281418 10222 90336798
Confusional state 11.40 10.51 1368 280059 384837 89962183
Chest pain 11.33 10.51 1146 280281 318499 90028521
Granulocytopenia 11.31 10.51 3 281424 6438 90340582
Speech disorder 11.26 10.51 89 281338 45496 90301524
Endocarditis 11.25 10.51 4 281423 7109 90339911
Muscle twitching 11.24 10.51 38 281389 24164 90322856
Asphyxia 11.23 10.51 4 281423 7099 90339921
Blood immunoglobulin G increased 11.21 10.51 27 281400 2945 90344075
Brain injury 11.18 10.51 5 281422 7733 90339287
Pneumothorax 11.18 10.51 27 281400 19140 90327880
Dyslipidaemia 11.14 10.51 9 281418 10098 90336922
Left atrial volume increased 11.11 10.51 5 281422 62 90346958
Orthostatic hypotension 11.05 10.51 187 281240 41640 90305380
Immune reconstitution inflammatory syndrome 11.02 10.51 4 281423 7015 90340005
Petechiae 11.01 10.51 20 281407 15721 90331299
Generalised oedema 10.99 10.51 27 281400 19026 90327994
Respiratory tract infection 10.89 10.51 124 281303 58954 90288066
Affect lability 10.89 10.51 25 281402 18038 90328982
Nightmare 10.87 10.51 33 281394 21692 90325328
Photophobia 10.86 10.51 32 281395 21237 90325783
Left ventricular dysfunction 10.84 10.51 18 281409 14651 90332369
Diplopia 10.83 10.51 49 281378 28665 90318355
Small intestinal obstruction 10.81 10.51 32 281395 21202 90325818
Blood pressure inadequately controlled 10.74 10.51 3 281424 6221 90340799
Head injury 10.73 10.51 55 281372 31133 90315887
Eosinophil count increased 10.68 10.51 15 281412 13066 90333954
Demyelination 10.65 10.51 6 281421 8134 90338886
Polyarthritis 10.58 10.51 26 281401 18324 90328696
Glomerular filtration rate decreased 10.56 10.51 23 281404 16909 90330111
Toxic encephalopathy 10.56 10.51 7 281420 8692 90338328

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 152.50 11.23 72 53312 266927 42301024
Toxicity to various agents 148.41 11.23 51 53333 229085 42338866
Coombs positive haemolytic anaemia 121.89 11.23 49 53335 1186 42566765
Appendicolith 118.96 11.23 113 53271 13343 42554608
Appendicitis 90.27 11.23 120 53264 20493 42547458
Blood phosphorus increased 90.04 11.23 94 53290 12431 42555520
Lymphadenitis 88.72 11.23 49 53335 2462 42565489
Constipation 81.34 11.23 410 52974 161881 42406070
Sleep disorder therapy 81.00 11.23 68 53316 6826 42561125
Myasthenia gravis 78.57 11.23 99 53285 16038 42551913
Analgesic therapy 78.00 11.23 65 53319 6459 42561492
Hyperphosphataemia 76.79 11.23 88 53296 12916 42555035
Fatigue 72.85 11.23 849 52535 434792 42133159
Ventricular fibrillation 67.40 11.23 129 53255 29994 42537957
Abdominal distension 66.12 11.23 219 53165 71516 42496435
Completed suicide 64.95 11.23 20 53364 96445 42471506
Drug therapy 63.00 11.23 57 53327 6323 42561628
Blood uric acid increased 62.75 11.23 87 53297 15460 42552491
Neuralgia 61.32 11.23 113 53271 25534 42542417
Iron deficiency 60.55 11.23 72 53312 10989 42556962
Epidural lipomatosis 60.52 11.23 34 53350 1766 42566185
Hypophosphataemia 58.76 11.23 99 53285 20846 42547105
Antacid therapy 58.48 11.23 48 53336 4669 42563282
Anticoagulant therapy 55.91 11.23 46 53338 4489 42563462
Blood cholesterol increased 54.35 11.23 110 53274 26631 42541320
Dry mouth 54.31 11.23 140 53244 39739 42528212
Nasopharyngitis 52.15 11.23 226 53158 83770 42484181
Victim of child abuse 49.85 11.23 26 53358 1163 42566788
Juvenile idiopathic arthritis 48.56 11.23 34 53350 2605 42565346
Bacterial infection 47.79 11.23 107 53277 27772 42540179
Stress 47.17 11.23 142 53242 44070 42523881
Acute kidney injury 47.06 11.23 269 53115 367068 42200883
Thrombosis 45.36 11.23 188 53196 68323 42499628
Intentional overdose 44.24 11.23 6 53378 51450 42516501
Incorrect route of product administration 42.46 11.23 94 53290 24211 42543740
Dry skin 40.51 11.23 143 53241 48195 42519756
Haemolysis 39.20 11.23 54 53330 9535 42558416
Cardiogenic shock 37.57 11.23 114 53270 35526 42532425
Aortic stenosis 36.89 11.23 50 53334 8695 42559256
Swelling 36.63 11.23 151 53233 54734 42513217
Chronic obstructive pulmonary disease 35.54 11.23 165 53219 62949 42505002
Activated partial thromboplastin time prolonged 35.43 11.23 68 53316 15835 42552116
Product dose omission issue 35.23 11.23 321 53063 154044 42413907
Ulcer 35.05 11.23 69 53315 16372 42551579
Rhabdomyolysis 34.77 11.23 28 53356 77991 42489960
Gout 34.66 11.23 95 53289 27960 42539991
Leukopenia 33.09 11.23 27 53357 74719 42493232
Hyperlipidaemia 32.94 11.23 79 53305 21437 42546514
Pruritus 32.75 11.23 371 53013 188400 42379551
Ascites 32.52 11.23 149 53235 56529 42511422
Blood calcium increased 32.17 11.23 46 53338 8408 42559543
Mucosal inflammation 31.87 11.23 11 53373 49363 42518588
Sleep disorder 31.84 11.23 132 53252 47963 42519988
Cardio-respiratory arrest 31.60 11.23 17 53367 58619 42509332
Overdose 31.53 11.23 52 53332 105212 42462739
Intentional product misuse 31.37 11.23 157 53227 61743 42506208
Coma 31.17 11.23 14 53370 53540 42514411
Stiff person syndrome 30.43 11.23 11 53373 197 42567754
Bronchopulmonary aspergillosis allergic 30.38 11.23 33 53351 4565 42563386
Suicide attempt 30.23 11.23 10 53374 46090 42521861
Treatment failure 29.80 11.23 21 53363 62603 42505348
Drug abuse 29.33 11.23 54 53330 104717 42463234
End stage renal disease 28.88 11.23 64 53320 16494 42551457
Muscle swelling 27.98 11.23 13 53371 451 42567500
Migraine 27.45 11.23 82 53302 25332 42542619
Thrombocytopenia 27.27 11.23 134 53250 190145 42377806
Migraine with aura 27.26 11.23 16 53368 903 42567048
Cytomegalovirus infection 27.22 11.23 4 53380 32302 42535649
Drug resistance 27.16 11.23 5 53379 34243 42533708
Iris hypopigmentation 26.81 11.23 7 53377 38 42567913
Renal failure 26.34 11.23 92 53292 143634 42424317
Interstitial lung disease 26.16 11.23 36 53348 78426 42489525
Total lung capacity decreased 26.03 11.23 27 53357 3543 42564408
Full blood count decreased 25.77 11.23 70 53314 20490 42547461
Hypotension 25.74 11.23 203 53181 257428 42310523
Diabetes mellitus 25.39 11.23 145 53239 59942 42508009
Child abuse 25.08 11.23 15 53369 877 42567074
Foetal exposure during pregnancy 25.08 11.23 14 53370 47297 42520654
Sinusitis 24.70 11.23 121 53263 47171 42520780
Injection related reaction 24.49 11.23 13 53371 603 42567348
Pancytopenia 23.91 11.23 72 53312 117671 42450280
Blood test abnormal 23.77 11.23 51 53333 12855 42555096
Corneal opacity 23.56 11.23 13 53371 652 42567299
Hemiparaesthesia 23.53 11.23 9 53375 190 42567761
Septic shock 23.29 11.23 50 53334 91622 42476329
Rhinocerebral mucormycosis 23.11 11.23 13 53371 677 42567274
Keratopathy 22.97 11.23 13 53371 685 42567266
Dermatitis atopic 22.83 11.23 49 53335 12355 42555596
Lactic acidosis 21.76 11.23 15 53369 45246 42522705
Drug reaction with eosinophilia and systemic symptoms 21.52 11.23 13 53371 42062 42525889
Respiratory depression 21.45 11.23 62 53322 18806 42549145
Seasonal allergy 21.18 11.23 37 53347 8018 42559933
Cytokine release syndrome 21.09 11.23 15 53369 44512 42523439
Eosinophilia 20.10 11.23 8 53376 32891 42535060
Dry eye 19.64 11.23 53 53331 15453 42552498
Influenza 19.44 11.23 139 53245 62036 42505915
Sedation 19.31 11.23 7 53377 30468 42537483
Asthenia 19.00 11.23 473 52911 280320 42287631
Lung hernia 18.88 11.23 6 53378 71 42567880
Muscle spasticity 18.80 11.23 32 53352 6790 42561161
Febrile neutropenia 18.68 11.23 146 53238 185557 42382394
Cholestasis 18.50 11.23 9 53375 32870 42535081
Depressed level of consciousness 18.10 11.23 20 53364 47950 42520001
Urinary tract infection 18.04 11.23 197 53187 99087 42468864
Bacteroides infection 17.85 11.23 19 53365 2568 42565383
Hypoaesthesia 17.51 11.23 151 53233 71312 42496639
Tenderness 17.40 11.23 36 53348 8847 42559104
Upper respiratory tract infection 17.31 11.23 101 53283 42072 42525879
Cataract 17.21 11.23 80 53304 30524 42537427
Hyperkalaemia 17.20 11.23 48 53336 80410 42487541
Accidental overdose 17.13 11.23 7 53377 28323 42539628
Aggression 17.12 11.23 18 53366 44145 42523806
Cough 16.85 11.23 315 53069 177788 42390163
Toxic anterior segment syndrome 16.70 11.23 14 53370 1402 42566549
Needle fatigue 16.43 11.23 13 53371 1200 42566751
Micturition urgency 16.43 11.23 42 53342 11856 42556095
Diarrhoea 16.11 11.23 718 52666 460131 42107820
Relapsing-remitting multiple sclerosis 16.04 11.23 14 53370 1481 42566470
Stevens-Johnson syndrome 16.03 11.23 4 53380 22174 42545777
Pneumonia 15.93 11.23 663 52721 421486 42146465
Crystal nephropathy 15.91 11.23 10 53374 639 42567312
Tubulointerstitial nephritis 15.78 11.23 10 53374 31538 42536413
Myocardial infarction 15.71 11.23 91 53293 123918 42444033
Angioedema 15.71 11.23 18 53366 42459 42525492
Madarosis 15.51 11.23 9 53375 497 42567454
Increased tendency to bruise 15.50 11.23 23 53361 4347 42563604
Hot flush 15.30 11.23 62 53322 22289 42545662
Neuroleptic malignant syndrome 15.28 11.23 4 53380 21468 42546483
Plasma cell myeloma 15.24 11.23 107 53277 47471 42520480
Infusion related reaction 15.17 11.23 129 53255 60677 42507274
Metabolic acidosis 15.16 11.23 26 53358 51832 42516119
Peripheral swelling 14.99 11.23 176 53208 90094 42477857
Keratitis viral 14.98 11.23 3 53381 3 42567948
Nocturia 14.94 11.23 41 53343 12071 42555880
Troponin increased 14.78 11.23 55 53329 19007 42548944
Gait spastic 14.73 11.23 13 53371 1396 42566555
Hepatic enzyme increased 14.69 11.23 103 53281 45681 42522270
Renal impairment 14.44 11.23 80 53304 110148 42457803
Flatulence 14.33 11.23 66 53318 25086 42542865
Rhinorrhoea 14.27 11.23 78 53306 31716 42536235
Ischaemic stroke 14.27 11.23 5 53379 22228 42545723
Nausea 14.24 11.23 620 52764 396179 42171772
Neurotoxicity 14.05 11.23 6 53378 23645 42544306
Blood pressure systolic abnormal 14.02 11.23 25 53359 5503 42562448
Lower respiratory tract infection 13.99 11.23 94 53290 41112 42526839
Hyponatraemia 13.94 11.23 191 53193 101271 42466680
Full blood count abnormal 13.89 11.23 74 53310 29802 42538149
Ulcerative keratitis 13.82 11.23 15 53369 2073 42565878
Haemophagocytic lymphohistiocytosis 13.74 11.23 3 53381 18219 42549732
Conjunctival scar 13.72 11.23 7 53377 299 42567652
Corneal disorder 13.60 11.23 11 53373 1048 42566903
Drug level increased 13.53 11.23 8 53376 26192 42541759
COVID-19 13.47 11.23 212 53172 115736 42452215
Corneal exfoliation 13.45 11.23 3 53381 7 42567944
Feeling abnormal 13.38 11.23 140 53244 69646 42498305
Ocular surface squamous neoplasia 13.38 11.23 4 53380 38 42567913
Haemoglobin decreased 13.11 11.23 236 53148 132235 42435716
Musculoskeletal stiffness 13.09 11.23 120 53264 57645 42510306
Taste disorder 13.04 11.23 35 53349 10172 42557779
Cardiac arrest 12.91 11.23 82 53302 109238 42458713
Respiratory arrest 12.91 11.23 10 53374 28414 42539537
Insomnia 12.91 11.23 214 53170 118039 42449912
Joint injury 12.79 11.23 44 53340 14632 42553319
Oesophageal injury 12.79 11.23 6 53378 213 42567738
Hepatotoxicity 12.56 11.23 8 53376 25159 42542792
Insulin autoimmune syndrome 12.54 11.23 8 53376 525 42567426
Fluid retention 12.51 11.23 75 53309 31544 42536407
Weight decreased 12.51 11.23 345 53039 207603 42360348
Skin exfoliation 12.47 11.23 92 53292 41461 42526490
Dizziness 12.42 11.23 404 52980 248850 42319101
Psychotic disorder 12.37 11.23 11 53373 29197 42538754
Hypertonic bladder 12.21 11.23 15 53369 2366 42565585
Throat irritation 12.17 11.23 40 53344 12996 42554955
Therapeutic response shortened 12.13 11.23 41 53343 13513 42554438
Premature baby 12.05 11.23 7 53377 23146 42544805
Pollakiuria 12.05 11.23 58 53326 22447 42545504
Sudden death 12.02 11.23 3 53381 16626 42551325
Muscle spasms 11.83 11.23 162 53222 85882 42482069
Benign prostatic hyperplasia 11.81 11.23 55 53329 20997 42546954
Conjunctival hyperaemia 11.67 11.23 17 53367 3159 42564792
Hepatic cytolysis 11.50 11.23 10 53374 26834 42541117
Electrocardiogram QT prolonged 11.48 11.23 27 53357 47918 42520033
Pain 11.47 11.23 394 52990 244454 42323497
Agranulocytosis 11.29 11.23 13 53371 30599 42537352

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 651.49 10.82 215 285525 480340 109823219
Drug interaction 617.32 10.82 260 285480 499923 109803636
Acute kidney injury 567.76 10.82 485 285255 634945 109668614
Rheumatoid arthritis 527.41 10.82 1838 283902 297775 110005784
Rheumatic fever 512.97 10.82 1039 284701 121540 110182019
Completed suicide 499.71 10.82 32 285708 242349 110061210
Night sweats 436.78 10.82 1027 284713 132956 110170603
Fibromyalgia 428.28 10.82 1186 284554 169723 110133836
Bursitis 426.96 10.82 999 284741 128919 110174640
Psoriatic arthropathy 412.27 10.82 1281 284459 195480 110108079
Lip dry 411.19 10.82 842 284898 99241 110204318
Type 2 diabetes mellitus 374.17 10.82 1157 284583 176075 110127484
Peripheral venous disease 358.99 10.82 719 285021 83398 110220161
Swollen joint count increased 353.33 10.82 712 285028 82949 110220610
Joint range of motion decreased 342.07 10.82 882 284858 120950 110182609
Blood cholesterol increased 330.39 10.82 1140 284600 183645 110119914
Facet joint syndrome 326.23 10.82 752 284988 96076 110207483
Duodenal ulcer perforation 323.57 10.82 1103 284637 176597 110126962
Irritable bowel syndrome 322.77 10.82 1046 284694 163169 110140390
Folliculitis 318.85 10.82 1056 284684 166597 110136962
Helicobacter infection 317.31 10.82 1113 284627 180764 110122795
Dry mouth 310.37 10.82 1178 284562 198770 110104789
Impaired healing 310.34 10.82 1165 284575 195552 110108007
Muscle injury 308.16 10.82 931 284809 139876 110163683
C-reactive protein abnormal 301.39 10.82 876 284864 128819 110174740
Wound 289.47 10.82 1287 284453 233150 110070409
Injury 288.96 10.82 1061 284679 176204 110127355
Temperature regulation disorder 286.38 10.82 249 285491 12577 110290982
Liver injury 284.74 10.82 946 284794 149467 110154092
Infusion related reaction 274.55 10.82 1805 283935 379357 109924202
Road traffic accident 273.59 10.82 750 284990 106648 110196911
Prescribed overdose 273.10 10.82 660 285080 86921 110216638
Lower limb fracture 272.56 10.82 602 285138 74746 110228813
Pemphigus 272.52 10.82 1188 284552 213382 110090177
Mobility decreased 272.01 10.82 1275 284465 236147 110067412
Deep vein thrombosis postoperative 271.38 10.82 522 285218 58769 110244790
Glossodynia 269.74 10.82 1213 284527 220791 110082768
Pericarditis 260.08 10.82 1189 284551 217925 110085634
Hepatic enzyme increased 254.83 10.82 1558 284182 319334 109984225
Neutropenia 254.51 10.82 358 285382 374262 109929297
Intentional overdose 252.11 10.82 25 285715 132476 110171083
Cardiac arrest 244.44 10.82 101 285639 196652 110106907
Sleep disorder due to general medical condition, insomnia type 243.93 10.82 712 285028 104931 110198628
Ill-defined disorder 243.26 10.82 924 284816 155929 110147630
Hypotension 242.65 10.82 630 285110 523219 109780340
Hand deformity 241.96 10.82 1162 284578 217344 110086215
Rheumatoid factor positive 241.23 10.82 819 284921 130821 110172738
Urticaria 239.36 10.82 1526 284214 317331 109986228
Autoimmune disorder 238.90 10.82 525 285215 64958 110238601
Sciatica 236.08 10.82 646 285094 91753 110211806
Renal failure 235.62 10.82 147 285593 226427 110077132
Joint swelling 232.25 10.82 1945 283795 440900 109862659
Obesity 230.83 10.82 731 285009 112620 110190939
Sleep disorder 229.86 10.82 1070 284670 197574 110105985
Food allergy 225.45 10.82 268 285472 19680 110283879
Blister 224.10 10.82 1170 284570 226206 110077353
Gait inability 219.45 10.82 813 284927 135563 110167996
Sinusitis 218.41 10.82 1413 284327 295275 110008284
Pancytopenia 217.95 10.82 136 285604 209477 110094082
Hypoaesthesia 217.11 10.82 1473 284267 312750 109990809
Systemic lupus erythematosus 214.08 10.82 1254 284486 253084 110050475
Febrile neutropenia 213.84 10.82 304 285436 316463 109987096
Coeliac disease 212.26 10.82 392 285348 42795 110260764
Asthma 211.28 10.82 1235 284505 249056 110054503
Lower respiratory tract infection 205.49 10.82 1200 284540 241906 110061653
Stomatitis 203.16 10.82 1294 284446 268948 110034611
Anti-cyclic citrullinated peptide antibody positive 202.32 10.82 969 284771 181015 110122544
Drug abuse 197.40 10.82 106 285634 177305 110126254
Osteoarthritis 196.26 10.82 963 284777 181660 110121899
Septic shock 193.83 10.82 82 285658 157446 110146113
Wound infection 193.57 10.82 619 285121 95846 110207713
Taste disorder 191.38 10.82 481 285259 64906 110238653
Cardio-respiratory arrest 189.31 10.82 35 285705 115801 110187758
Rhabdomyolysis 187.13 10.82 41 285699 120360 110183199
Synovitis 184.62 10.82 1277 284463 272815 110030744
Wheezing 178.96 10.82 1201 284539 254029 110049530
Suicide attempt 178.37 10.82 27 285713 103367 110200192
Musculoskeletal pain 177.69 10.82 938 284802 182085 110121474
Live birth 176.69 10.82 485 285255 68999 110234560
Breast cancer stage III 176.68 10.82 527 285213 78590 110224969
Contraindicated product administered 176.33 10.82 1172 284568 247095 110056464
Nasopharyngitis 169.34 10.82 1659 284081 392702 109910857
Abdominal pain upper 168.59 10.82 1506 284234 347605 109955954
Lupus vulgaris 167.07 10.82 308 285432 33575 110269984
Immunodeficiency 166.87 10.82 333 285407 38505 110265054
Swelling 166.80 10.82 1509 284231 349532 109954027
Peripheral swelling 165.42 10.82 1683 284057 402351 109901208
Renal impairment 165.26 10.82 146 285594 188299 110115260
Hyperkalaemia 164.98 10.82 72 285668 135724 110167835
Sensitisation 163.83 10.82 113 285627 4038 110299521
X-ray abnormal 162.79 10.82 326 285414 37791 110265768
Lung disorder 156.83 10.82 896 284844 179151 110124408
Cardiac failure 155.53 10.82 153 285587 187473 110116086
C-reactive protein 153.71 10.82 279 285461 30052 110273507
Seizure 150.48 10.82 211 285529 220974 110082585
Myocardial infarction 149.79 10.82 165 285575 191918 110111641
Interstitial lung disease 149.58 10.82 87 285653 139247 110164312
Polycystic ovaries 149.18 10.82 113 285627 4683 110298876
Lactic acidosis 147.52 10.82 30 285710 92781 110210778
Blepharospasm 143.59 10.82 387 285353 54464 110249095
Hypercholesterolaemia 143.15 10.82 538 285202 90299 110213260
Ear pain 142.83 10.82 379 285361 52847 110250712
Arthropathy 142.73 10.82 1248 284492 286274 110017285
Weight increased 140.54 10.82 1680 284060 417964 109885595
Respiratory failure 135.26 10.82 217 285523 215115 110088444
Drug ineffective 135.23 10.82 2950 282790 1517590 108785969
Migraine 135.19 10.82 832 284908 170820 110132739
Adverse event 133.89 10.82 597 285143 108212 110195347
Gastrooesophageal reflux disease 132.84 10.82 858 284882 179118 110124441
Ejection fraction 132.33 10.82 87 285653 2868 110300691
Inflammation 132.23 10.82 904 284836 192334 110111225
Metabolic acidosis 130.82 10.82 47 285693 99697 110203862
Angioedema 129.89 10.82 46 285694 98454 110205105
Drug reaction with eosinophilia and systemic symptoms 129.52 10.82 27 285713 82068 110221491
Retinitis 129.20 10.82 269 285471 32058 110271501
Bradycardia 128.67 10.82 127 285613 155390 110148169
Anaemia 128.24 10.82 857 284883 546229 109757330
Electrocardiogram QT prolonged 127.32 10.82 61 285679 108899 110194660
Disease progression 126.73 10.82 276 285464 243758 110059801
Mucosal inflammation 124.90 10.82 46 285694 96095 110207464
Treatment failure 124.69 10.82 1178 284562 276056 110027503
Grip strength decreased 122.33 10.82 470 285270 79704 110223855
Alopecia 121.98 10.82 1460 284280 363293 109940266
Onychomadesis 121.36 10.82 324 285416 45339 110258220
Liver disorder 121.31 10.82 704 285036 141539 110162020
Muscle spasms 118.73 10.82 1169 284571 276988 110026571
Hypersensitivity 117.62 10.82 1576 284164 402422 109901137
Abdominal discomfort 115.72 10.82 1539 284201 392319 109911240
Pain 114.38 10.82 3252 282488 951703 109351856
Muscle spasticity 113.36 10.82 272 285468 35643 110267916
Cholestasis 113.24 10.82 16 285724 64502 110239057
Death 112.34 10.82 1209 284531 697660 109605899
Adjustment disorder with depressed mood 112.24 10.82 307 285433 43576 110259983
Musculoskeletal stiffness 112.22 10.82 1161 284579 278661 110024898
Hypokalaemia 110.72 10.82 188 285552 182260 110121299
Discomfort 109.67 10.82 938 284802 213769 110089790
Loss of consciousness 109.56 10.82 213 285527 196093 110107466
Gastrointestinal disorder 108.24 10.82 1027 284713 240925 110062634
Hypoglycaemia 107.88 10.82 85 285655 116019 110187540
Insomnia 106.73 10.82 1411 284329 359179 109944380
Serotonin syndrome 105.41 10.82 14 285726 59139 110244420
Thrombocytopenia 105.27 10.82 503 285237 348382 109955177
Cytokine release syndrome 105.15 10.82 26 285714 70280 110233279
Eosinophilia 104.96 10.82 13 285727 57923 110245636
Anti-cyclic citrullinated peptide antibody 104.17 10.82 186 285554 19778 110283781
Laryngitis 103.83 10.82 292 285448 42119 110261440
Hepatocellular injury 103.38 10.82 7 285733 50635 110252924
Dislocation of vertebra 102.15 10.82 296 285444 43425 110260134
Chronic sinusitis 101.73 10.82 210 285530 24874 110278685
Memory impairment 99.84 10.82 859 284881 196085 110107474
Product quality issue 98.80 10.82 429 285311 76870 110226689
Syncope 98.72 10.82 237 285503 202299 110101260
Malignant neoplasm progression 97.77 10.82 189 285551 174378 110129181
Dyspepsia 97.37 10.82 834 284906 190131 110113428
Contusion 96.78 10.82 975 284765 232386 110071173
Intentional product use issue 96.75 10.82 1023 284717 246883 110056676
Cytomegalovirus infection 96.74 10.82 13 285727 54431 110249128
Maternal exposure timing unspecified 93.68 10.82 183 285557 20830 110282729
Hepatic cytolysis 93.53 10.82 15 285725 55038 110248521
Upper respiratory tract infection 93.18 10.82 620 285120 130708 110172851
Myelosuppression 92.90 10.82 65 285675 94275 110209284
Drug hypersensitivity 90.79 10.82 1663 284077 452427 109851132
Vaginal flatulence 90.48 10.82 133 285607 12011 110291548
Leukopenia 88.74 10.82 155 285585 148636 110154923
Suicidal ideation 88.25 10.82 68 285672 93869 110209690
Ulcer haemorrhage 88.07 10.82 186 285554 22385 110281174
Exostosis 87.74 10.82 290 285450 45666 110257893
Tubulointerstitial nephritis 87.41 10.82 17 285723 54267 110249292
Respiratory disorder 87.31 10.82 391 285349 70991 110232568
Agranulocytosis 86.43 10.82 26 285714 61734 110241825
Frequent bowel movements 85.79 10.82 389 285351 71001 110232558
Macular degeneration 85.11 10.82 179 285561 21480 110282079
Encephalopathy 85.03 10.82 52 285688 81003 110222556
Lupus-like syndrome 84.77 10.82 265 285475 40527 110263032
Sepsis 83.70 10.82 499 285241 326847 109976712
Fluid retention 83.17 10.82 471 285269 93836 110209723
Rash maculo-papular 83.04 10.82 44 285696 74178 110229381
Paraesthesia 83.02 10.82 1085 284655 275436 110028123
Agitation 79.73 10.82 105 285635 112946 110190613
Alanine aminotransferase increased 78.94 10.82 229 285511 183544 110120015
Nail disorder 78.26 10.82 327 285413 57608 110245951
Ventricular tachycardia 77.76 10.82 17 285723 49992 110253567
Prescribed underdose 77.47 10.82 354 285386 64820 110238739
Coombs positive haemolytic anaemia 76.94 10.82 49 285691 1528 110302031
Dehydration 76.89 10.82 416 285324 279095 110024464
Therapeutic product effect decreased 76.86 10.82 967 284773 243349 110060210
Hepatic failure 76.53 10.82 41 285699 68698 110234861
Respiratory arrest 75.55 10.82 28 285712 58271 110245288
Foetal death 75.54 10.82 143 285597 15902 110287657
Ischaemic stroke 75.38 10.82 9 285731 41254 110262305
Hip arthroplasty 75.37 10.82 315 285425 55498 110248061
Tachycardia 74.79 10.82 316 285424 226329 110077230
Bone marrow failure 74.60 10.82 28 285712 57820 110245739
Hypertension 74.49 10.82 1784 283956 508300 109795259
Pregnancy 74.34 10.82 295 285445 50772 110252787
Aggression 74.14 10.82 30 285710 59180 110244379
Product use issue 73.68 10.82 1173 284567 310522 109993037
Atrial fibrillation 73.44 10.82 324 285416 229318 110074241
Disorientation 73.21 10.82 46 285694 70625 110232934
Headache 72.30 10.82 2875 282865 879502 109424057
Psychotic disorder 72.09 10.82 21 285719 50916 110252643
Bone erosion 70.86 10.82 272 285468 46099 110257460
Hypoxia 70.12 10.82 143 285597 129372 110174187
Maternal exposure during pregnancy 69.89 10.82 984 284756 253899 110049660
Hallucination 68.72 10.82 97 285643 101335 110202224
Liver function test abnormal 68.56 10.82 47 285693 68903 110234656
Neurotoxicity 68.42 10.82 13 285727 42194 110261365
Anaphylactic reaction 68.22 10.82 119 285621 114181 110189378
International normalised ratio increased 68.21 10.82 74 285666 86698 110216861
Carpal tunnel syndrome 67.90 10.82 168 285572 22442 110281117
Proctitis 67.81 10.82 141 285599 16786 110286773
Drug resistance 66.72 10.82 31 285709 56343 110247216
Female genital tract fistula 66.64 10.82 138 285602 16381 110287178
Constipation 66.53 10.82 1296 284444 356490 109947069
Acute myocardial infarction 66.35 10.82 71 285669 83706 110219853
Intentional self-injury 66.35 10.82 9 285731 37420 110266139
Blood creatinine increased 66.05 10.82 246 285494 182643 110120916
Melaena 65.57 10.82 49 285691 68708 110234851
Breast cancer stage II 65.56 10.82 187 285553 27188 110276371
Hepatic cirrhosis 65.17 10.82 346 285394 67280 110236279
Generalised tonic-clonic seizure 64.82 10.82 30 285710 54650 110248909
Vaginal discharge 64.64 10.82 143 285597 17765 110285794
Rhinitis allergic 64.56 10.82 143 285597 17779 110285780
Multiple organ dysfunction syndrome 64.46 10.82 190 285550 151520 110152039
Exposure during pregnancy 64.40 10.82 689 285051 166735 110136824
Ejection fraction abnormal 63.17 10.82 60 285680 3400 110300159
Hypomagnesaemia 62.95 10.82 39 285701 60331 110243228
Oedema 62.62 10.82 823 284917 209153 110094406
Haemophagocytic lymphohistiocytosis 62.59 10.82 5 285735 31554 110272005
Coma 62.25 10.82 132 285608 117737 110185822
Back injury 62.05 10.82 265 285475 47134 110256425
Sleep disorder due to a general medical condition 61.90 10.82 283 285457 51829 110251730
Stevens-Johnson syndrome 61.66 10.82 22 285718 46879 110256680
Blood test abnormal 61.65 10.82 188 285552 28366 110275193
Pulmonary embolism 61.32 10.82 315 285425 214159 110089400
Neuroleptic malignant syndrome 60.83 10.82 8 285732 34051 110269508
Drug level increased 60.04 10.82 24 285716 47695 110255864
Gastrointestinal haemorrhage 59.53 10.82 223 285517 165295 110138264
Toxic anterior segment syndrome 59.48 10.82 58 285682 3396 110300163
Poisoning 59.48 10.82 4 285736 29101 110274458
Hepatotoxicity 59.41 10.82 46 285694 63354 110240205
Altered state of consciousness 59.02 10.82 38 285702 57588 110245971
Haematuria 58.63 10.82 77 285663 82928 110220631
Therapeutic product effect incomplete 58.55 10.82 857 284883 222948 110080611
Tremor 58.40 10.82 296 285444 201936 110101623
Pneumocystis jirovecii pneumonia 58.00 10.82 19 285721 42716 110260843
Blood creatine phosphokinase increased 57.80 10.82 62 285678 73015 110230544
Acute hepatic failure 57.51 10.82 12 285728 36456 110267103
Respiratory distress 57.24 10.82 56 285684 68818 110234741
Sedation complication 56.97 10.82 145 285595 19710 110283849
Pleural effusion 56.65 10.82 251 285489 177458 110126101
Drug ineffective for unapproved indication 56.14 10.82 113 285627 102725 110200834
Posterior reversible encephalopathy syndrome 55.81 10.82 10 285730 33851 110269708
Knee arthroplasty 55.70 10.82 322 285418 64626 110238933
Anaphylactic shock 55.57 10.82 32 285708 51514 110252045
Shock 55.35 10.82 35 285705 53553 110250006
Hepatic function abnormal 55.09 10.82 91 285649 89204 110214355
Therapy partial responder 54.85 10.82 14 285726 37047 110266512
Cerebrovascular accident 54.84 10.82 261 285479 181023 110122536
Pulmonary fibrosis 54.83 10.82 451 285289 101591 110201968
Aspartate aminotransferase increased 54.62 10.82 220 285520 159716 110143843
Labelled drug-drug interaction medication error 54.51 10.82 6 285734 29296 110274263
Nephrectomy 54.44 10.82 49 285691 2591 110300968
Radiculopathy 54.23 10.82 140 285600 19196 110284363
Circulatory collapse 53.48 10.82 22 285718 42971 110260588
Creatinine renal clearance decreased 53.20 10.82 150 285590 21665 110281894
Blood bilirubin increased 53.12 10.82 71 285669 75901 110227658
Status epilepticus 52.74 10.82 9 285731 31562 110271997
Poisoning deliberate 52.71 10.82 4 285736 26327 110277232
Paraesthesia oral 52.68 10.82 199 285541 33472 110270087
Onychomycosis 52.44 10.82 218 285522 38313 110265246
Hyponatraemia 52.38 10.82 338 285402 217315 110086244
Pulmonary oedema 52.09 10.82 114 285626 100545 110203014
Appendicolith 51.64 10.82 114 285626 14141 110289418
Cardiac failure congestive 50.75 10.82 209 285531 150791 110152768
Accidental overdose 50.65 10.82 36 285704 51798 110251761
Hyperglycaemia 50.40 10.82 89 285651 85001 110218558
Hypocalcaemia 50 10.82 57 285683 65309 110238250
Hypothermia 49.92 10.82 5 285735 26297 110277262
Toxic epidermal necrolysis 49.64 10.82 44 285696 56683 110246876
Polyneuropathy 49.53 10.82 11 285729 32001 110271558
Dysphagia 49.53 10.82 216 285524 153384 110150175
Unresponsive to stimuli 49.48 10.82 55 285685 63735 110239824
Incorrect route of product administration 49.45 10.82 309 285431 63752 110239807
Colitis ulcerative 49.40 10.82 356 285384 77007 110226552
Thrombotic microangiopathy 49.39 10.82 8 285732 29141 110274418
Haematemesis 49.19 10.82 48 285692 59060 110244499
Transaminases increased 48.79 10.82 55 285685 63335 110240224
Acute respiratory distress syndrome 48.09 10.82 40 285700 53158 110250401
Hallucination, visual 48.09 10.82 21 285719 39584 110263975
Myoclonus 47.82 10.82 13 285727 32985 110270574
Deep vein thrombosis 47.40 10.82 193 285547 139694 110163865
Haemodynamic instability 47.20 10.82 3 285737 22885 110280674
Drug intolerance 46.68 10.82 1378 284362 405134 109898425
Therapy non-responder 46.65 10.82 616 285124 156691 110146868
Ear infection 46.20 10.82 299 285441 62433 110241126
Pneumonia 45.98 10.82 1826 283914 874888 109428671
Aspergillus infection 45.79 10.82 6 285734 25610 110277949
Swollen tongue 45.78 10.82 53 285687 60309 110243250
Arrhythmia 45.68 10.82 68 285672 69507 110234052
Cough 44.72 10.82 882 284858 460759 109842800
Haematoma 44.72 10.82 51 285689 58425 110245134
Rash erythematous 44.67 10.82 363 285377 81469 110222090
Mental status changes 43.85 10.82 81 285659 76041 110227518
Porphyria acute 43.73 10.82 127 285613 18653 110284906
Transplant rejection 43.33 10.82 6 285734 24561 110278998
Somnolence 42.81 10.82 527 285213 296922 110006637
Haematotoxicity 42.78 10.82 3 285737 21079 110282480
Lupus vasculitis 42.64 10.82 24 285716 594 110302965
Dyskinesia 42.55 10.82 42 285698 51404 110252155
Oxygen saturation decreased 42.40 10.82 235 285505 156747 110146812
Drug eruption 41.91 10.82 46 285694 53613 110249946
Pneumonitis 41.85 10.82 84 285656 76447 110227112
Schizophrenia 41.81 10.82 4 285736 21822 110281737
Jaundice 41.78 10.82 55 285685 59181 110244378
Myalgia 41.37 10.82 371 285369 222010 110081549
Pallor 41.31 10.82 51 285689 56416 110247143
Metastases to liver 41.04 10.82 20 285720 35366 110268193
Inappropriate antidiuretic hormone secretion 41.02 10.82 18 285722 33833 110269726
Walking aid user 40.73 10.82 150 285590 24925 110278634
Hypocholesterolaemia 40.36 10.82 65 285675 6356 110297203
Dystonia 39.66 10.82 9 285731 25796 110277763
Abnormal behaviour 39.63 10.82 26 285714 39013 110264546
Pancreatitis acute 39.49 10.82 59 285681 60215 110243344
Acute generalised exanthematous pustulosis 38.90 10.82 5 285735 21659 110281900
Extrapyramidal disorder 38.88 10.82 13 285727 28854 110274705
Cerebral infarction 38.79 10.82 46 285694 51792 110251767
Subdural haematoma 38.77 10.82 23 285717 36431 110267128
Disturbance in attention 38.41 10.82 63 285677 61932 110241627
Sinus tachycardia 38.35 10.82 35 285705 44458 110259101
Aplastic anaemia 38.33 10.82 8 285732 24300 110279259
Sleep disorder therapy 38.20 10.82 69 285671 7402 110296157
Procedural pain 37.77 10.82 187 285553 35378 110268181
Urinary retention 37.66 10.82 77 285663 69606 110233953
Keratopathy 37.60 10.82 30 285710 1343 110302216
Rash 37.55 10.82 2531 283209 818433 109485126
Hypercalcaemia 37.55 10.82 39 285701 46618 110256941
Dysarthria 37.46 10.82 103 285637 84018 110219541
Epilepsy 37.41 10.82 410 285330 99799 110203760
Body temperature increased 37.41 10.82 256 285484 54457 110249102
Miosis 37.32 10.82 6 285734 21977 110281582
Dyspnoea 37.08 10.82 2414 283326 1104458 109199101
Epstein-Barr virus infection 37.08 10.82 3 285737 18735 110284824
Angina pectoris 37.04 10.82 65 285675 62230 110241329
Swollen joint count 36.81 10.82 74 285666 8600 110294959
Osteonecrosis of jaw 36.59 10.82 42 285698 47975 110255584
Gamma-glutamyltransferase increased 36.42 10.82 64 285676 61245 110242314
Osteonecrosis 36.30 10.82 21 285719 33720 110269839
Psoriasis 36.17 10.82 535 285205 139458 110164101
Bronchopulmonary aspergillosis 35.99 10.82 16 285724 29847 110273712
Cerebral haemorrhage 35.79 10.82 71 285669 64897 110238662
Joint dislocation 35.76 10.82 179 285561 34011 110269548
Face oedema 35.76 10.82 21 285719 33448 110270111
Subcutaneous drug absorption impaired 35.73 10.82 68 285672 7591 110295968
Psychomotor hyperactivity 35.65 10.82 5 285735 20272 110283287
Analgesic therapy 35.64 10.82 66 285674 7218 110296341
Infection 35.58 10.82 1205 284535 360995 109942564
Peritonitis 35.50 10.82 20 285720 32587 110270972
Body tinea 35.46 10.82 35 285705 2080 110301479
Fatigue 35.37 10.82 3622 282118 1212336 109091223
Nervous system disorder 35.19 10.82 19 285721 31702 110271857
Tachypnoea 35.15 10.82 30 285710 39365 110264194
Disability 35.05 10.82 163 285577 30060 110273499
Disseminated intravascular coagulation 34.97 10.82 33 285707 41253 110262306
Blood calcium decreased 34.94 10.82 184 285556 35661 110267898
Neutropenic sepsis 34.72 10.82 18 285722 30728 110272831
Blood pressure decreased 34.63 10.82 166 285574 114925 110188634
Toxic skin eruption 34.35 10.82 14 285726 27501 110276058
Epidural lipomatosis 34.28 10.82 34 285706 2033 110301526
Chronic kidney disease 34.28 10.82 93 285647 76198 110227361
Underdose 34.19 10.82 281 285459 63273 110240286
Myelodysplastic syndrome 34.11 10.82 28 285712 37456 110266103
Diabetic ketoacidosis 34.03 10.82 35 285705 42023 110261536
Febrile bone marrow aplasia 34.00 10.82 3 285737 17462 110286097
Blood phosphorus increased 33.81 10.82 106 285634 16234 110287325
Acute coronary syndrome 33.69 10.82 9 285731 23103 110280456
Blood lactate dehydrogenase increased 33.54 10.82 39 285701 44295 110259264
Pruritus 33.51 10.82 1830 283910 579730 109723829
Overlap syndrome 33.44 10.82 73 285667 8986 110294573
Escherichia infection 33.37 10.82 10 285730 23806 110279753
Coronary artery disease 33.27 10.82 86 285654 71604 110231955
Coagulopathy 33.15 10.82 34 285706 40877 110262682
Akathisia 33.15 10.82 3 285737 17110 110286449
Hyperbilirubinaemia 33.12 10.82 19 285721 30652 110272907
Multiple fractures 32.96 10.82 72 285668 8868 110294691
Anuria 32.72 10.82 11 285729 24330 110279229
Haemorrhage intracranial 32.66 10.82 17 285723 28952 110274607
Palpitations 32.58 10.82 259 285481 158953 110144606
Lymphadenopathy 32.45 10.82 73 285667 63762 110239797
Progressive multifocal leukoencephalopathy 32.31 10.82 12 285728 24944 110278615
Victim of child abuse 32.18 10.82 26 285714 1185 110302374
Foot deformity 32.06 10.82 225 285515 48255 110255304
Muscle rigidity 32.06 10.82 11 285729 24020 110279539
Tumour lysis syndrome 31.97 10.82 20 285720 30781 110272778
Pathogen resistance 31.92 10.82 4 285736 17668 110285891
Creatinine renal clearance increased 31.90 10.82 43 285697 3582 110299977
Oliguria 31.88 10.82 5 285735 18652 110284907
Nightmare 31.83 10.82 32 285708 38831 110264728
Hepatitis cholestatic 31.67 10.82 4 285736 17562 110285997
Acute myeloid leukaemia 31.65 10.82 31 285709 38079 110265480
Product administration error 31.22 10.82 30 285710 37187 110266372
Bronchiectasis 31.10 10.82 29 285711 36464 110267095
Sinus bradycardia 30.80 10.82 19 285721 29464 110274095
Device expulsion 30.78 10.82 21 285719 30870 110272689
Adverse drug reaction 30.72 10.82 412 285328 105147 110198412
Sleep apnoea syndrome 30.53 10.82 194 285546 40253 110263306
Cholelithiasis 30.27 10.82 75 285665 63347 110240212
Deafness transitory 30.18 10.82 24 285716 1069 110302490
General physical health deterioration 30.02 10.82 1365 284375 423930 109879629
Diabetes mellitus inadequate control 29.99 10.82 20 285720 29755 110273804
Parkinsonism 29.87 10.82 10 285730 22177 110281382
Subarachnoid haemorrhage 29.86 10.82 20 285720 29682 110273877
Haemoptysis 29.84 10.82 90 285650 71264 110232295
Lymphadenitis 29.72 10.82 52 285688 5441 110298118
Hyperthermia 29.68 10.82 9 285731 21263 110282296
Osteoporosis 29.57 10.82 350 285390 86802 110216757
Rheumatoid nodule 29.40 10.82 8 285732 20288 110283271
Haemorrhage 29.20 10.82 159 285581 106533 110197026
Incorrect dose administered 29.17 10.82 153 285587 103488 110200071
Hallucination, auditory 29.01 10.82 16 285724 26381 110277178
Joint stiffness 28.83 10.82 283 285457 66960 110236599
Hemiparesis 28.73 10.82 43 285697 43860 110259699
Immune reconstitution inflammatory syndrome 28.53 10.82 4 285736 16222 110287337
Skin necrosis 28.43 10.82 10 285730 21502 110282057
Myocardial ischaemia 28.15 10.82 17 285723 26667 110276892
Red blood cell sedimentation rate increased 28.15 10.82 318 285422 77984 110225575
Infusion site reaction 28.07 10.82 105 285635 17577 110285982
Shock haemorrhagic 27.86 10.82 18 285722 27229 110276330
Leukocytosis 27.82 10.82 61 285679 53767 110249792
Injection site reaction 27.75 10.82 352 285388 88718 110214841
Adverse reaction 27.55 10.82 150 285590 29444 110274115
Haemolytic anaemia 27.18 10.82 10 285730 20910 110282649
Panniculitis 27.03 10.82 4 285736 15578 110287981
Neutrophil count decreased 27.00 10.82 192 285548 120749 110182810
Nephropathy toxic 26.96 10.82 19 285721 27459 110276100
Neuropathy peripheral 26.78 10.82 315 285425 178962 110124597
Staphylococcal infection 26.62 10.82 92 285648 69852 110233707
Chills 26.53 10.82 340 285400 190240 110113319
Treatment noncompliance 26.45 10.82 98 285642 72892 110230667
Presyncope 26.44 10.82 54 285686 48833 110254726
Myopathy 26.19 10.82 16 285724 24944 110278615
Drug withdrawal syndrome 26.16 10.82 36 285704 38018 110265541
Drug therapy 26.07 10.82 58 285682 7233 110296326
Enterococcal infection 26.02 10.82 10 285730 20356 110283203
Epistaxis 25.79 10.82 214 285526 130158 110173401
Tuberculosis 25.76 10.82 7 285733 17767 110285792
Clostridium difficile colitis 25.73 10.82 46 285694 43732 110259827
Infection susceptibility increased 25.59 10.82 43 285697 4355 110299204
Lung infiltration 25.55 10.82 16 285724 24612 110278947
Prostate cancer 25.49 10.82 36 285704 37605 110265954
Right ventricular failure 25.39 10.82 18 285722 25936 110277623
Weight fluctuation 25.36 10.82 119 285621 22026 110281533
Product label confusion 25.35 10.82 121 285619 22556 110281003
Premature delivery 25.34 10.82 25 285715 30607 110272952
Sudden death 25.10 10.82 16 285724 24379 110279180
Hyperammonaemia 25.07 10.82 3 285737 13729 110289830
Renal tubular necrosis 25.06 10.82 25 285715 30450 110273109
Mydriasis 24.98 10.82 13 285727 22144 110281415
Pericardial effusion 24.77 10.82 71 285669 57146 110246413
General symptom 24.76 10.82 64 285676 8782 110294777
Antacid therapy 24.74 10.82 48 285692 5436 110298123
Adrenal insufficiency 24.51 10.82 45 285695 42345 110261214
Proteinuria 24.48 10.82 41 285699 39977 110263582
Tenosynovitis 24.39 10.82 6 285734 16277 110287282
Hepatitis acute 24.33 10.82 9 285731 18757 110284802
C-reactive protein increased 24.25 10.82 736 285004 217183 110086376
Cardiac murmur 24.20 10.82 17 285723 24611 110278948
Nail bed inflammation 24.14 10.82 28 285712 2002 110301557
Nasal mucosal disorder 24.14 10.82 27 285713 1856 110301703
Overdose 24.05 10.82 442 285298 233352 110070207
Atrioventricular block first degree 23.88 10.82 4 285736 14221 110289338
Mania 23.75 10.82 12 285728 20784 110282775
BK virus infection 23.59 10.82 3 285737 13103 110290456
Gastroenteritis 23.51 10.82 40 285700 38760 110264799
Myasthenia gravis 23.48 10.82 114 285626 21397 110282162
Vertigo 23.47 10.82 130 285610 86740 110216819
Electrocardiogram QRS complex prolonged 23.39 10.82 3 285737 13018 110290541
Fall 23.35 10.82 1298 284442 602184 109701375
Myocarditis 23.21 10.82 26 285714 30029 110273530
Anticoagulant therapy 23.06 10.82 46 285694 5315 110298244
Spondylitis 22.95 10.82 73 285667 11265 110292294
Cardiomegaly 22.72 10.82 25 285715 29105 110274454
Finger deformity 22.72 10.82 155 285585 32937 110270622
Electrolyte imbalance 22.59 10.82 38 285702 36990 110266569
Blood glucose increased 22.51 10.82 226 285514 132270 110171289
Tardive dyskinesia 22.40 10.82 4 285736 13575 110289984
Renal function test abnormal 22.29 10.82 62 285678 8884 110294675
Klebsiella infection 22.18 10.82 12 285728 19997 110283562
Platelet count decreased 22.06 10.82 441 285299 230002 110073557
Liver function test increased 21.94 10.82 336 285404 88212 110215347
Asphyxia 21.76 10.82 5 285735 14210 110289349
Hyperphosphataemia 21.76 10.82 92 285648 16289 110287270
Diffuse large B-cell lymphoma 21.69 10.82 7 285733 15891 110287668
Stoma site dermatitis 21.69 10.82 12 285728 287 110303272
Hepatic steatosis 21.58 10.82 60 285680 48771 110254788
Gastric ulcer 21.53 10.82 44 285696 39783 110263776
Delusion 21.30 10.82 18 285722 23737 110279822
Drug-induced liver injury 21.30 10.82 432 285308 119635 110183924
Graft versus host disease 21.25 10.82 11 285729 18795 110284764
Hypertensive crisis 21.21 10.82 19 285721 24353 110279206
Ataxia 21.19 10.82 28 285712 30080 110273479
Decreased appetite 21.16 10.82 1464 284276 474382 109829177
Aphasia 20.87 10.82 80 285660 58917 110244642
Dermatitis atopic 20.85 10.82 125 285615 25416 110278143
Cardiomyopathy 20.83 10.82 34 285706 33491 110270068
Hepatomegaly 20.75 10.82 15 285725 21399 110282160
Acute respiratory failure 20.68 10.82 112 285628 75148 110228411
Acute pulmonary oedema 20.65 10.82 9 285731 16987 110286572
Pulmonary toxicity 20.63 10.82 10 285730 17736 110285823
Pulmonary congestion 20.59 10.82 30 285710 30936 110272623
Basal cell carcinoma 20.47 10.82 55 285685 45215 110258344
Obstructive defaecation 20.35 10.82 11 285729 251 110303308
Metastases to bone 20.27 10.82 31 285709 31341 110272218
No adverse event 20.22 10.82 110 285630 73729 110229830
Blood immunoglobulin M increased 20.18 10.82 23 285717 1614 110301945
Generalised oedema 20.16 10.82 30 285710 30674 110272885
Pulmonary hypertension 20.10 10.82 74 285666 55146 110248413
Dyspnoea exertional 20.05 10.82 172 285568 103888 110199671
Product substitution issue 20.04 10.82 18 285722 23043 110280516
Oral candidiasis 19.99 10.82 190 285550 44570 110258989
Vasculitis 19.93 10.82 39 285701 35834 110267725
Mouth ulceration 19.93 10.82 61 285679 48077 110255482
Congestive cardiomyopathy 19.87 10.82 6 285734 14213 110289346
Device malfunction 19.86 10.82 22 285718 25536 110278023
Blood urea increased 19.78 10.82 74 285666 54883 110248676
Tendonitis 19.67 10.82 23 285717 26060 110277499
Partial seizures 19.49 10.82 3 285737 11346 110292213
Bundle branch block right 19.47 10.82 4 285736 12287 110291272
Ankylosing spondylitis 19.40 10.82 8 285732 15604 110287955
Cardiac tamponade 19.39 10.82 3 285737 11304 110292255
Catatonia 19.37 10.82 3 285737 11297 110292262
Granuloma skin 19.33 10.82 3 285737 11280 110292279
Ileus 19.25 10.82 31 285709 30698 110272861
Enteritis 19.12 10.82 13 285727 19143 110284416
Haemodialysis 19.10 10.82 11 285729 17708 110285851
Acidosis 19.09 10.82 18 285722 22513 110281046
Immune thrombocytopenia 19.02 10.82 18 285722 22476 110281083
Lichen sclerosus 18.98 10.82 19 285721 1149 110302410
Jaundice cholestatic 18.95 10.82 7 285733 14601 110288958
Metastases to lung 18.88 10.82 19 285721 23044 110280515
Hypervolaemia 18.86 10.82 65 285675 49395 110254164
Hyperthyroidism 18.82 10.82 29 285711 29232 110274327
Lymphopenia 18.78 10.82 48 285692 40122 110263437
Appendicitis 18.76 10.82 132 285608 28332 110275227
Decreased immune responsiveness 18.68 10.82 61 285679 9545 110294014
Adenovirus infection 18.66 10.82 3 285737 10991 110292568
Bladder cancer 18.66 10.82 15 285725 20277 110283282
Pulseless electrical activity 18.64 10.82 10 285730 16747 110286812
Rash vesicular 18.47 10.82 81 285659 14571 110288988
Gastric haemorrhage 18.45 10.82 9 285731 15906 110287653
Iris hypopigmentation 18.39 10.82 7 285733 67 110303492
Renal injury 18.28 10.82 13 285727 18700 110284859
Stress cardiomyopathy 18.23 10.82 9 285731 15797 110287762
Pneumothorax 18.22 10.82 40 285700 35245 110268314
Organising pneumonia 18.19 10.82 7 285733 14236 110289323
Disease recurrence 18.09 10.82 88 285652 60696 110242863
Endocarditis 18.05 10.82 6 285734 13365 110290194
Dysuria 18.04 10.82 87 285653 60144 110243415
Mucormycosis 17.82 10.82 3 285737 10625 110292934
Oesophageal carcinoma 17.75 10.82 4 285736 11520 110292039
Rebound effect 17.74 10.82 8 285732 14798 110288761
Cyanosis 17.71 10.82 31 285709 29710 110273849
Intestinal ischaemia 17.50 10.82 10 285730 16169 110287390
Seronegative arthritis 17.50 10.82 74 285666 13103 110290456
Atrioventricular block 17.46 10.82 11 285729 16866 110286693
Obstructive airways disorder 17.36 10.82 61 285679 46088 110257471
Cystitis haemorrhagic 17.34 10.82 5 285735 12204 110291355
Renal cancer 17.33 10.82 6 285734 13028 110290531
Caesarean section 17.30 10.82 7 285733 13810 110289749
Encephalitis 17.23 10.82 14 285726 18825 110284734
Coronary artery stenosis 17.17 10.82 7 285733 13751 110289808
Emotional distress 17.06 10.82 59 285681 44788 110258771
Toxic encephalopathy 17.04 10.82 9 285731 15205 110288354
Amnesia 16.99 10.82 374 285366 105034 110198525
Large intestine perforation 16.98 10.82 11 285729 16618 110286941
Blood pressure systolic increased 16.98 10.82 135 285605 82856 110220703
Accidental exposure to product 16.93 10.82 69 285671 49939 110253620
Kidney transplant rejection 16.86 10.82 5 285735 11982 110291577
Skin ulcer 16.78 10.82 96 285644 63549 110240010
Heart rate increased 16.70 10.82 266 285474 143568 110159991
Granulocytopenia 16.65 10.82 6 285734 12709 110290850
Malnutrition 16.64 10.82 28 285712 27251 110276308
Brain injury 16.59 10.82 7 285733 13469 110290090
Personality change 16.58 10.82 4 285736 10998 110292561
Azotaemia 16.57 10.82 3 285737 10082 110293477
Erythema multiforme 16.57 10.82 18 285722 21079 110282480
Corneal erosion 16.50 10.82 12 285728 467 110303092
Skin toxicity 16.41 10.82 5 285735 11778 110291781
Enterocolitis 16.22 10.82 15 285725 18934 110284625
Left atrial volume increased 16.15 10.82 7 285733 96 110303463
Cestode infection 16.11 10.82 10 285730 298 110303261
Ejection fraction decreased 16.08 10.82 53 285687 40827 110262732
Systemic infection 15.97 10.82 3 285737 9816 110293743
Bacteraemia 15.97 10.82 56 285684 42334 110261225
Erysipelas 15.94 10.82 7 285733 13151 110290408
Sputum discoloured 15.86 10.82 30 285710 27915 110275644
Hemiparaesthesia 15.85 10.82 11 285729 397 110303162
Bronchospasm 15.85 10.82 34 285706 30205 110273354
Gastritis 15.83 10.82 78 285662 53621 110249938
Hydronephrosis 15.82 10.82 18 285722 20647 110282912
Device related infection 15.71 10.82 51 285689 39468 110264091
Chest discomfort 15.66 10.82 336 285404 173512 110130047
Cachexia 15.62 10.82 7 285733 12998 110290561
Blood sodium decreased 15.55 10.82 49 285691 38270 110265289
Paranoia 15.55 10.82 21 285719 22353 110281206
Cerebral haematoma 15.54 10.82 3 285737 9629 110293930
Mental disorder 15.46 10.82 50 285690 38741 110264818
Child abuse 15.44 10.82 15 285725 874 110302685
Apnoea 15.38 10.82 8 285732 13631 110289928
Gastrointestinal stoma output abnormal 15.28 10.82 11 285729 421 110303138
Abortion spontaneous 15.24 10.82 42 285698 34240 110269319
Functional gastrointestinal disorder 15.15 10.82 42 285698 6007 110297552
Chronic graft versus host disease 15.14 10.82 3 285737 9454 110294105
Dialysis 15.12 10.82 17 285723 19602 110283957
Spinal fusion surgery 15.06 10.82 55 285685 9101 110294458
Faecaloma 15.04 10.82 10 285730 14898 110288661
Rhinocerebral mucormycosis 14.91 10.82 19 285721 1498 110302061
Cytopenia 14.85 10.82 35 285705 30081 110273478
Hypogammaglobulinaemia 14.82 10.82 18 285722 20058 110283501
Pustular psoriasis 14.78 10.82 72 285668 13533 110290026
Device dislocation 14.73 10.82 38 285702 31666 110271893
Staphylococcal sepsis 14.72 10.82 14 285726 17440 110286119
Blood alkaline phosphatase increased 14.69 10.82 115 285625 70820 110232739
Burning sensation 14.68 10.82 256 285484 68956 110234603
Bradyphrenia 14.59 10.82 6 285734 11722 110291837
Arteriosclerosis 14.58 10.82 26 285714 24741 110278818
Multiple-drug resistance 14.58 10.82 8 285732 13227 110290332
Cushingoid 14.55 10.82 6 285734 11706 110291853
Antinuclear antibody positive 14.49 10.82 3 285737 9165 110294394
Lung hernia 14.49 10.82 6 285734 73 110303486
Pulmonary arterial hypertension 14.40 10.82 40 285700 32528 110271031
Colorectal cancer 14.37 10.82 3 285737 9111 110294448
Arteriospasm coronary 14.34 10.82 3 285737 9097 110294462
Respiratory acidosis 14.32 10.82 9 285731 13817 110289742
Spinal pain 14.32 10.82 16 285724 18499 110285060
Device use error 14.31 10.82 3 285737 9086 110294473
Product use in unapproved indication 14.29 10.82 1342 284398 446035 109857524
Grip strength 14.28 10.82 54 285686 9087 110294472
Nasal cyst 14.26 10.82 5 285735 37 110303522
Restlessness 14.23 10.82 86 285654 56173 110247386
Blood lactic acid increased 14.17 10.82 12 285728 15809 110287750
Hepatocellular carcinoma 14.12 10.82 4 285736 9876 110293683
Normal newborn 14.11 10.82 101 285639 21795 110281764
Herpes simplex 14.07 10.82 12 285728 15752 110287807
Neoplasm malignant 14.04 10.82 49 285691 37094 110266465
Premenstrual syndrome 14.00 10.82 12 285728 594 110302965
Eye injury 13.97 10.82 48 285692 7707 110295852
Blood pressure increased 13.95 10.82 536 285204 257837 110045722
Lung neoplasm malignant 13.92 10.82 43 285697 33799 110269760
Fear of injection 13.91 10.82 3 285737 8908 110294651
Atrioventricular block complete 13.80 10.82 19 285721 20063 110283496
Metabolic disorder 13.70 10.82 5 285735 10505 110293054
Speech disorder 13.61 10.82 98 285642 61471 110242088
Behaviour disorder 13.61 10.82 4 285736 9643 110293916
Autoimmune hepatitis 13.54 10.82 11 285729 14793 110288766
Ventricular hypokinesia 13.53 10.82 6 285734 11208 110292351
Clonus 13.47 10.82 3 285737 8713 110294846
Sleep disorder due to general medical condition, hypersomnia type 13.46 10.82 21 285719 1998 110301561
Hydrocephalus 13.41 10.82 5 285735 10370 110293189
Gastrointestinal toxicity 13.39 10.82 6 285734 11142 110292417
Staphylococcal bacteraemia 13.37 10.82 14 285726 16674 110286885
Nausea 13.33 10.82 2907 282833 1232783 109070776
Vaginal haemorrhage 13.30 10.82 28 285712 25046 110278513
Congenital neuropathy 13.26 10.82 4 285736 17 110303542
Intestinal perforation 13.24 10.82 21 285719 20923 110282636
Ocular pemphigoid 13.23 10.82 8 285732 227 110303332
Irritability 13.21 10.82 71 285669 47738 110255821
Left ventricular hypertrophy 13.20 10.82 9 285731 13235 110290324
Pemphigoid 13.19 10.82 19 285721 19688 110283871
Supraventricular tachycardia 13.18 10.82 27 285713 24395 110279164
Brow ptosis 13.11 10.82 8 285732 231 110303328
Blood immunoglobulin A decreased 13.11 10.82 22 285718 2226 110301333
Inhibitory drug interaction 13.04 10.82 35 285705 4912 110298647
Palmar-plantar erythrodysaesthesia syndrome 13.03 10.82 58 285682 40967 110262592
Haemoglobin decreased 12.99 10.82 518 285222 248209 110055350
Upper gastrointestinal haemorrhage 12.98 10.82 76 285664 50020 110253539
Lymphoma 12.96 10.82 20 285720 20151 110283408
Potentiating drug interaction 12.88 10.82 7 285733 11636 110291923
Injection related reaction 12.81 10.82 18 285722 1560 110301999
Incoherent 12.67 10.82 3 285737 8355 110295204
Oesophageal candidiasis 12.66 10.82 7 285733 11527 110292032
Second primary malignancy 12.51 10.82 17 285723 18051 110285508
Metastasis 12.47 10.82 3 285737 8264 110295295
Tachyarrhythmia 12.46 10.82 3 285737 8258 110295301
Hemiplegia 12.46 10.82 25 285715 22757 110280802
Head injury 12.39 10.82 63 285677 42954 110260605
Laryngeal oedema 12.23 10.82 5 285735 9802 110293757
Fear 12.22 10.82 26 285714 23167 110280392
Atelectasis 12.21 10.82 51 285689 36661 110266898
Anal incontinence 12.10 10.82 24 285716 21940 110281619
Fracture 12.07 10.82 29 285711 24759 110278800
Colitis ischaemic 11.99 10.82 17 285723 17733 110285826
Intentional product misuse 11.99 10.82 438 285302 132466 110171093
Polyuria 11.97 10.82 17 285723 17721 110285838
Hypovolaemic shock 11.95 10.82 12 285728 14571 110288988
Gastric disorder 11.95 10.82 45 285695 33312 110270247
Sarcoidosis 11.95 10.82 9 285731 12570 110290989
Brain herniation 11.92 10.82 4 285736 8859 110294700
Hepatic cancer 11.92 10.82 7 285733 11149 110292410
Lethargy 11.91 10.82 170 285570 93406 110210153
Back pain 11.86 10.82 1113 284627 369883 109933676
Left ventricular dysfunction 11.83 10.82 27 285713 23466 110280093
Cholecystitis acute 11.81 10.82 14 285726 15768 110287791
Pneumonia bacterial 11.80 10.82 32 285708 26229 110277330
Death neonatal 11.76 10.82 18 285722 1685 110301874
Hypotonia 11.75 10.82 14 285726 15731 110287828
Neutrophilia 11.73 10.82 6 285734 10323 110293236
Wrong technique in product usage process 11.72 10.82 157 285583 87191 110216368
Cholangitis 11.69 10.82 15 285725 16320 110287239
Varicose vein 11.68 10.82 42 285698 6898 110296661
Cardiopulmonary failure 11.67 10.82 3 285737 7900 110295659
Hypovolaemia 11.67 10.82 24 285716 21650 110281909
Ileus paralytic 11.67 10.82 8 285732 11729 110291830
Orthopnoea 11.66 10.82 7 285733 11014 110292545
Swelling face 11.65 10.82 168 285572 92153 110211406
Dermatitis bullous 11.63 10.82 17 285723 17512 110286047
Petechiae 11.58 10.82 27 285713 23290 110280269
Granuloma 11.57 10.82 5 285735 9485 110294074
Lip swelling 11.52 10.82 80 285660 50587 110252972
Paralysis 11.50 10.82 14 285726 15586 110287973
Blood uric acid increased 11.48 10.82 95 285645 21434 110282125
Ventricular extrasystoles 11.42 10.82 26 285714 22615 110280944
Product preparation error 11.41 10.82 57 285683 10822 110292737
Drug level above therapeutic 11.38 10.82 8 285732 11580 110291979
Unevaluable event 11.36 10.82 98 285642 59129 110244430
Flank pain 11.31 10.82 27 285713 23103 110280456
Crepitations 11.29 10.82 7 285733 10828 110292731
Hepatitis fulminant 11.28 10.82 4 285736 8556 110295003
Fumbling 11.25 10.82 6 285734 133 110303426
Nasal obstruction 11.25 10.82 26 285714 3324 110300235
Ketoacidosis 11.25 10.82 6 285734 10081 110293478
Balance disorder 11.22 10.82 387 285353 116173 110187386
Stiff person syndrome 11.21 10.82 11 285729 649 110302910
Prothrombin time prolonged 11.20 10.82 17 285723 17244 110286315
Pyelonephritis 11.18 10.82 31 285709 25219 110278340
Guillain-Barre syndrome 11.12 10.82 7 285733 10737 110292822
Odynophagia 11.11 10.82 12 285728 14089 110289470
Anal fistula 11.09 10.82 4 285736 8469 110295090
Cardiac failure acute 11.08 10.82 29 285711 24049 110279510
Pain in jaw 11.05 10.82 82 285658 51095 110252464
Necrosis 11.04 10.82 8 285732 11398 110292161
Duodenal ulcer 11.03 10.82 21 285719 19493 110284066
Depressed level of consciousness 11.00 10.82 214 285526 112064 110191495
Necrotising fasciitis 10.98 10.82 3 285737 7588 110295971
Muscle twitching 10.97 10.82 40 285700 29895 110273664
Duodenitis 10.97 10.82 5 285735 9191 110294368
Premature labour 10.92 10.82 5 285735 9167 110294392
Urinary incontinence 10.91 10.82 77 285663 48510 110255049

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic shock 23.32 19.04 3 3 9 113938

Pharmacologic Action:

SourceCodeDescription
ATC D03AX05 DERMATOLOGICALS
PREPARATIONS FOR TREATMENT OF WOUNDS AND ULCERS
CICATRIZANTS
Other cicatrizants
ATC M09AX01 MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
OTHER DRUGS FOR DISORDERS OF THE MUSCULO-SKELETAL SYSTEM
Other drugs for disorders of the musculo-skeletal system
ATC R01AX09 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Other nasal preparations
ATC S01KA01 SENSORY ORGANS
OPHTHALMOLOGICALS
SURGICAL AIDS
Viscoelastic substances
ATC S01KA51 SENSORY ORGANS
OPHTHALMOLOGICALS
SURGICAL AIDS
Viscoelastic substances
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D007155 Immunologic Factors
MeSH PA D020011 Protective Agents
MeSH PA D055675 Viscosupplements
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:233423 antifibrotic agent
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:77715 nasal decongestant

Related Drugs by ATC class:

D03AX Other cicatrizants 9 drugs
becaplerminberemagene geperpaveccalcium pantothenatecrilanomerdexpanthenolenoxolonesodium chloritetrafermintrolamine
M09AX Other drugs for disorders of the musculo-skeletal system 11 drugs
aceneuramic acidatalurencasimerseneteplirsengivinostatgolodirsennusinersenonasemnogene abeparvovecpalovarotenerisdiplamviltolarsen
R01AX Other nasal preparations 6 drugs
framycetinhexamidineipratropiummupirocinretinolritiometan

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Surgical procedure on eye proper indication 373353005
Operation on lens indication 386612009
Glaucoma contraindication 23986001 DOID:1686




🐶 Veterinary Drug Use

SpeciesUseRelation
Horses Joint dysfunction caused by noninfectious synovitis associated with osteoarthritis Indication

🐶 Veterinary products

ProductApplicantIngredients
Hylartin V, Hylartin V Injection Zoetis Inc. 1
Hyvisc Anika Therapeutics 1
Equron Zoetis Inc. 1
Synacid Intervet Inc. 1
Hyalovet Boehringer lngelheim Animal Health USA Inc. 1
Legend Injectable Solution, Legend Multi Dose Boehringer lngelheim Animal Health USA Inc. 1
NexHA Vetoquinol USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019426 VUID
N0000147557 NUI
D08043 KEGG_DRUG
9067-32-7 SECONDARY_CAS_RN
4019426 VANDF
4020205 VANDF
C0020196 UMLSCUI
CHEBI:16336 CHEBI
CHEMBL5314376 ChEMBL_ID
CHEMBL4594244 ChEMBL_ID
D006820 MESH_DESCRIPTOR_UI
DB08818 DRUGBANK_ID
S270N0TRQY UNII
42892 RXNORM
119505 MMSL
18314 MMSL
26653 MMSL
5484 MMSL
d04329 MMSL
d05234 MMSL
002239 NDDF
006663 NDDF
015689 NDDF
38218009 SNOMEDCT_US
387578003 SNOMEDCT_US
96278006 SNOMEDCT_US
S270N0TRQY INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ginsamin Beauty HUMAN OTC DRUG LABEL 4 44738-6001 GRANULE 60 mg ORAL unapproved drug other 3 sections
Cotta HUMAN OTC DRUG LABEL 3 58748-001 FILM, EXTENDED RELEASE 0.30 g TOPICAL unapproved drug other 8 sections
WELLAGE FAMILY MASK SMALL HUMAN OTC DRUG LABEL 1 69346-0001 PATCH 0.06 g TOPICAL unapproved drug other 7 sections
WELLAGE FAMILY MASK LARGE HUMAN OTC DRUG LABEL 1 69346-0008 PATCH 0.06 g TOPICAL unapproved drug other 7 sections
WELLAGE Hyaluronic Acid Micro Needle HUMAN OTC DRUG LABEL 1 69346-9001 PATCH 99 g TOPICAL unapproved drug other 8 sections
Clapiel Hyalon Serum HUMAN OTC DRUG LABEL 2 69977-020 CREAM 10.50 mg TOPICAL unapproved drug other 8 sections
Hyaluronic Acid Micro HUMAN OTC DRUG LABEL 1 70018-010 PATCH 1.14 g TOPICAL unapproved drug other 8 sections
Ramosu Hyaluronic Acid Solution 100 HUMAN OTC DRUG LABEL 1 70465-0003 LIQUID 100 g TOPICAL unapproved drug other 6 sections
Im Fill HUMAN OTC DRUG LABEL 1 70514-0009 PATCH 99.97 g TOPICAL unapproved drug other 7 sections
Hyaluronic Acid Gel HUMAN OTC DRUG LABEL 1 70663-001 GEL 3.50 mg TOPICAL unapproved drug other 12 sections
Hyaluronic Acid Gel HUMAN OTC DRUG LABEL 1 70663-005 GEL 3.50 mg TOPICAL unapproved drug other 12 sections
XR CELLULAR MAGIC HUMAN OTC DRUG LABEL 1 70663-008 GEL 0.10 mg TOPICAL unapproved drug other 10 sections
DEEPAIR MICRO INTENSIVE MAGIC HUMAN OTC DRUG LABEL 1 70961-0001 PATCH 6.10 g TOPICAL unapproved drug other 7 sections
PRO PH Filler HUMAN OTC DRUG LABEL 1 71066-0002 GEL 1000 g TOPICAL unapproved drug other 5 sections
KAEWOON FOR MEN HUMAN OTC DRUG LABEL 2 71237-003 GEL 20 mg TOPICAL unapproved drug other 8 sections
KAEWOON FOR WOMEN HUMAN OTC DRUG LABEL 2 71237-004 GEL 20 mg TOPICAL unapproved drug other 8 sections
HYALURON 3S SERUM HUMAN OTC DRUG LABEL 1 71276-140 CREAM 0.15 g TOPICAL unapproved drug other 8 sections
Le-Blen EGF Serum HUMAN OTC DRUG LABEL 2 72271-100 LOTION 0.40 g TOPICAL unapproved drug other 7 sections
Le-Blen FGF Serum HUMAN OTC DRUG LABEL 3 72271-101 EMULSION 0.40 g TOPICAL unapproved drug other 8 sections
Le-Blen Nano Collagen Peptide Serum HUMAN OTC DRUG LABEL 3 72271-102 LOTION 0.54 g TOPICAL unapproved drug other 8 sections
Le-Blen Vitamin C Serum HUMAN OTC DRUG LABEL 2 72271-103 LOTION 2.84 g TOPICAL unapproved drug other 8 sections
Miracle Aqua Peeling HUMAN OTC DRUG LABEL 1 72557-001 GEL 0.01 g TOPICAL unapproved drug other 8 sections
Miracle Laser Mask HUMAN OTC DRUG LABEL 1 72557-005 CREAM 0.00 g TOPICAL unapproved drug other 8 sections
DR.PLINUS FILLINCELL MULTI HUMAN OTC DRUG LABEL 3 72630-020 PATCH 0.21 g TOPICAL unapproved drug other 10 sections
ELCOSYS HUMAN OTC DRUG LABEL 1 72910-0001 PATCH 99.97 mg TOPICAL unapproved drug other 7 sections
PokePoke Patch HUMAN OTC DRUG LABEL 1 72910-0002 PATCH 94.39 mg TOPICAL unapproved drug other 7 sections
FUNEES HUMAN OTC DRUG LABEL 1 72910-0003 PATCH 6.14 g TOPICAL unapproved drug other 7 sections
ASCORBYL PALMITATE 2% / HYALURONIC ACID SODIUM SALT 0.2% / NIACINAMIDE 5% / TRETINOIN 0.025% HUMAN PRESCRIPTION DRUG LABEL 3 72934-1088 GEL 0.20 g TOPICAL unapproved drug other 4 sections
CALCIPOTRIENE 0.005% / DICLOFENAC SODIUM 3% / HYALURONIC ACID SODIUM SALT 2% / NIACINAMIDE 2% HUMAN PRESCRIPTION DRUG LABEL 4 72934-2030 CREAM 2 g TOPICAL unapproved drug other 3 sections
FLUOCINONIDE 0.05% / HYALURONIC ACID SODIUM SALT 0.5% / NIACINAMIDE 4% HUMAN PRESCRIPTION DRUG LABEL 2 72934-2086 CREAM 0.50 g TOPICAL unapproved drug other 4 sections