nifuratel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5-nitrofuran derivatives 1926 4936-47-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metilmercadon
  • nifuratel
  • methylmercadone
Local antiprotozoal and antifungal agent that may also be given orally.
  • Molecular weight: 285.27
  • Formula: C10H11N3O5S
  • CLOGP: 0.79
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 0
  • TPSA: 100.86
  • ALOGS: -3.42
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.60 g O
0.60 g V

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TTK 40
kinase-selectivity-class AXL,BRAF,CDK9,DYRK1B,GRK2,GSK3B,MAP2K6,MAPK7,STK33,SYK,TEK,TTK 12
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G01AX05 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Other antiinfectives and antiseptics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D000994 Antitrichomonal Agents

Related Drugs by ATC class:

G01AX Other antiinfectives and antiseptics 10 drugs
ciclopiroxclodantoinfurazolidonehexetidineinosinemethylrosanilineoctenidinepolicresulenpovidone-iodineprotiofate

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.18 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167137 NUI
D01050 KEGG_DRUG
C0028070 UMLSCUI
CHEBI:135180 CHEBI
CHEMBL514315 ChEMBL_ID
DB13724 DRUGBANK_ID
D009545 MESH_DESCRIPTOR_UI
6433427 PUBCHEM_CID
12348 IUPHAR_LIGAND_ID
2314 INN_ID
U60U6P08SP UNII
7419 RXNORM
005304 NDDF
703418002 SNOMEDCT_US
703419005 SNOMEDCT_US

Pharmaceutical products:

None