furazolidone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1257 67-45-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • furazolidone
  • diafuron
  • furaxone
  • furazol
  • furazolidinone
  • furazolidon
  • furazon
  • furidon
  • nitrofurazolidone
  • nitrofuroxon
  • furoxone
A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone acts by gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514)
  • Molecular weight: 225.16
  • Formula: C8H7N3O5
  • CLOGP: -0.04
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 0
  • TPSA: 98.18
  • ALOGS: -2.79
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 20, 1958 FDA SHIRE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC G01AX06 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Other antiinfectives and antiseptics
ATC P01AB51 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
Nitroimidazole derivatives
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:38623 monoamine oxidase inhibitors
CHEBI has role CHEBI:50685 antitrichomonal agent
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D000994 Antitrichomonal Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D008996 Monoamine Oxidase Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Prevention of bacterial infection of superficial wounds, abrasions, lacerations, and pyogenic dermatitis Indication
Horses Prevention of bacterial infection of superficial wounds, abrasions, lacerations, and following firing (heat or electrocautery) Indication

🐶 Veterinary products

ProductApplicantIngredients
Furox Aerosol Powder, Topazone Aerosol Powder Kinetic Technologies LLC 1
Furall Farnam Companies Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018877 VUID
N0000147172 NUI
D00830 KEGG_DRUG
4018877 VANDF
C0016855 UMLSCUI
CHEBI:5195 CHEBI
FUR PDB_CHEM_ID
CHEMBL1103 ChEMBL_ID
DB00614 DRUGBANK_ID
D005664 MESH_DESCRIPTOR_UI
5323714 PUBCHEM_CID
273 INN_ID
5J9CPU3RE0 UNII
224944 RXNORM
416 MMSL
4768 MMSL
d00243 MMSL
002855 NDDF
416556006 SNOMEDCT_US
91314000 SNOMEDCT_US

Pharmaceutical products:

None