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dantron 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3125 | 117-10-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
mild purgative anthraquinone derivative chemically related to emodin, the active principle of cascara and other naturally occurring products such as senna, aloes and rhubarb, it acts on the nerve endings of the myenteric plexus and stimulates the muscles of the large intestine
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 50 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 3.479 | High | 0.82 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.557 | High | 0.82 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 25.586 | 10^-6 cm/s | High | 0.82 |
| dh-clint | Dog hepatocyte intrinsic clearance | 423.643 | uL/min/10^6 cells | High | 0.82 |
| dppb | Dog plasma protein binding (% unbound) | 0.550 | % | High | 0.82 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 0.890 | % | High | 0.82 |
| herg | hERG pIC50 | 4.412 | pIC50 | High | 0.82 |
| hh-clint | Human hepatocyte intrinsic clearance | 264.241 | uL/min/10^6 cells | High | 0.82 |
| hlm-clint | Human liver microsomal intrinsic clearance | 75.683 | uL/min/mg protein | High | 0.82 |
| hppb | Human plasma protein binding (% unbound) | 0.750 | % | High | 0.82 |
| kinase-safety-class | AAK1,ACVR1B,ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BLK,BMX,BRAF,BTK,CAMK2A,CAMK2B,CAMK2D,CAMK2G,CDK1,CDK14,CDK16,CDK19,CDK2,CDK3,CDK4,CDK5,CDK6,CDK7,CDK9,CHEK1,CHUK,CLK2,CLK4,CSF1R,DDR1,DYRK1B,DYRK2,DYRK3,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,ERBB4,FGFR1,FGFR4,FLT1,FLT3,FLT4,GRK1,GRK2,GRK3,GSK3A,GSK3B,HASPIN,HIPK2,IGF1R,IKBKB,INSR,INSRR,IRAK1,ITK,JAK1,JAK2,KDR,KIT,LYN,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K14,MAP3K2,MAP3K21,MAP3K3,MAP3K7,MAP3K8,MAP3K9,MAP4K1,MAP4K2,MAP4K3,MAP4K5,MAPK1,MAPK10,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK1,MARK2,MARK4,MELK,MET,MINK1,MTOR,NTRK1,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PIM3,PLK1,PRKAA1,PRKAA2,PRKCD,PRKCZ,PRKDC,PTK2,PTK6,SGK1,SIK2,SIK3,SRC,STK10,STK17A,STK33,SYK,TBK1,TEK,TGFBR1,TNIK,TTK,TYRO3,UHMK1,ULK1,ULK2,ZAP70 | 141 | |||
| kinase-selectivity-class | ACVR2A,ACVR2B,ALK,AURKA,AURKB,AURKC,AXL,BMX,BRAF,CAMK2B,CAMK2D,CDK1,CDK16,CDK2,CDK4,CDK7,CDK9,CLK4,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT3,FLT4,GRK2,GSK3A,GSK3B,IKBKB,IRAK1,IRAK3,JAK1,JAK2,KIT,MAP2K3,MAP2K6,MAP3K10,MAP3K11,MAP3K14,MAP3K2,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MARK4,MET,MINK1,MTOR,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM3,PRKAA1,PRKAA2,PRKDC,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TGFBR1,TNIK,TTK,TYRO3,ULK1,ULK2 | 76 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 0.570 | High | 0.82 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 479.733 | High | 0.82 | |
| mppb | Mouse plasma protein binding (% unbound) | 0.760 | High | 0.82 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.129 | High | 0.82 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 0.870 | % | High | 0.82 |
| rh-clint | Rat hepatocyte intrinsic clearance | 209.894 | uL/min/10^6 cells | High | 0.82 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 17.090 | % | High | 0.82 |
| rppb | Rat plasma protein binding (% unbound) | 0.440 | % | High | 0.82 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 8.974 | uM | High | 0.82 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 19, 1994 | UK Medicines and Healthcare Products Regulatory Agency (MHRA) | Napp Pharmaceuticals Ltd |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A06AB03 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
| ATC | A06AB53 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
| ATC | A06AG03 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Enemas |
| MeSH PA | D002400 | Cathartics |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D009153 | Mutagens |
| MeSH PA | D009676 | Noxae |
| CHEBI has role | CHEBI:50503 | laxative |
| CHEBI has role | CHEBI:68495 | apoptosis inducer |
| CHEBI has role | CHEBI:76924 | plant metabolite |
Related Drugs by ATC class:
A06AB Contact laxatives 6 drugs
A06AG Enemas 5 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Constipation | indication | 14760008 | DOID:2089 |
| Incontinence of feces | contraindication | 72042002 | |
| Appendicitis | contraindication | 74400008 | DOID:8337 |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Urinary incontinence | contraindication | 165232002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.56 | acidic |
| pKa2 | 9.34 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] B | Enzyme | IC50 | 4.23 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | IC50 | 4.97 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018988 | VUID |
| N0000179096 | NUI |
| D07107 | KEGG_DRUG |
| 4018988 | VANDF |
| C0057135 | UMLSCUI |
| CHEBI:3682 | CHEBI |
| CHZ | PDB_CHEM_ID |
| CHEMBL53418 | ChEMBL_ID |
| DB04816 | DRUGBANK_ID |
| C004315 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2950 | PUBCHEM_CID |
| 22293 | RXNORM |
| 001171 | NDDF |
| 387364000 | SNOMEDCT_US |
| 65884003 | SNOMEDCT_US |
| 81 | INN_ID |
| Z4XE6IBF3V | UNII |
| Z4XE6IBF3V | INXIGHT DRUGS |
Pharmaceutical products:
None