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| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4779 | 10040-45-6 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
contains two active ingredients, sodium picosulfate and magnesium citrate, which are both laxatives; structure
|
| Dose | Unit | Route |
|---|---|---|
| 5 | mg | O |
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 16, 2012 | FDA | FERRING PHARMS AS |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Food allergy | 457.96 | 22.45 | 165 | 13691 | 25313 | 90589278 |
| Immunodeficiency | 379.86 | 22.45 | 167 | 13689 | 43067 | 90571524 |
| Overdose | 337.31 | 22.45 | 240 | 13616 | 157469 | 90457122 |
| Intentional product misuse | 313.94 | 22.45 | 186 | 13670 | 89418 | 90525173 |
| Temperature regulation disorder | 267.78 | 22.45 | 96 | 13760 | 14483 | 90600108 |
| Prescribed overdose | 249.63 | 22.45 | 166 | 13690 | 97459 | 90517132 |
| Hyperhidrosis | 249.59 | 22.45 | 189 | 13667 | 136116 | 90478475 |
| Foetal death | 218.00 | 22.45 | 91 | 13765 | 20632 | 90593959 |
| Exposure during pregnancy | 138.28 | 22.45 | 176 | 13680 | 238234 | 90376357 |
| Cognitive disorder | 115.40 | 22.45 | 91 | 13765 | 69316 | 90545275 |
| Fluid retention | 114.22 | 22.45 | 100 | 13756 | 87991 | 90526600 |
| Creatinine renal clearance increased | 109.90 | 22.45 | 34 | 13822 | 3247 | 90611344 |
| Hypertension | 107.52 | 22.45 | 224 | 13632 | 457308 | 90157283 |
| Hyponatraemia | 102.80 | 22.45 | 114 | 13742 | 133424 | 90481167 |
| Renal function test abnormal | 101.33 | 22.45 | 39 | 13817 | 7152 | 90607439 |
| Reduced facial expression | 96.35 | 22.45 | 29 | 13827 | 2524 | 90612067 |
| Listless | 93.56 | 22.45 | 30 | 13826 | 3219 | 90611372 |
| Creatinine renal clearance decreased | 92.67 | 22.45 | 49 | 13807 | 18850 | 90595741 |
| Product use issue | 92.45 | 22.45 | 174 | 13682 | 329745 | 90284846 |
| Hepatic enzyme increased | 92.24 | 22.45 | 183 | 13673 | 360553 | 90254038 |
| Sedation complication | 88.99 | 22.45 | 46 | 13810 | 16898 | 90597693 |
| Urinary retention | 84.03 | 22.45 | 59 | 13797 | 37685 | 90576906 |
| Rash erythematous | 82.55 | 22.45 | 73 | 13783 | 65031 | 90549560 |
| Constipation | 82.42 | 22.45 | 151 | 13705 | 280244 | 90334347 |
| Coeliac disease | 81.78 | 22.45 | 62 | 13794 | 44548 | 90570043 |
| Multiple drug therapy | 77.80 | 22.45 | 32 | 13824 | 6977 | 90607614 |
| Apathy | 72.84 | 22.45 | 35 | 13821 | 11005 | 90603586 |
| Decreased immune responsiveness | 67.81 | 22.45 | 31 | 13825 | 8717 | 90605874 |
| Psoriasis | 67.14 | 22.45 | 97 | 13759 | 147657 | 90466934 |
| Blood calcium decreased | 66.76 | 22.45 | 47 | 13809 | 30135 | 90584456 |
| Cholestatic liver injury | 65.93 | 22.45 | 24 | 13832 | 3773 | 90610818 |
| Ileus | 62.17 | 22.45 | 36 | 13820 | 16510 | 90598081 |
| Orthostatic hypotension | 61.36 | 22.45 | 51 | 13805 | 41776 | 90572815 |
| Thrombocytopenia | 58.26 | 22.45 | 110 | 13746 | 208615 | 90405976 |
| Infusion related reaction | 58.01 | 22.45 | 167 | 13689 | 416613 | 90197978 |
| Depressed level of consciousness | 55.72 | 22.45 | 62 | 13794 | 72722 | 90541869 |
| Hypersensitivity | 55.56 | 22.45 | 174 | 13682 | 454503 | 90160088 |
| Sedation | 55.13 | 22.45 | 51 | 13805 | 48120 | 90566471 |
| Head discomfort | 54.72 | 22.45 | 33 | 13823 | 16300 | 90598291 |
| Off label use | 53.27 | 22.45 | 318 | 13538 | 1101934 | 89512657 |
| Drug interaction | 53.06 | 22.45 | 125 | 13731 | 276328 | 90338263 |
| Upper respiratory tract infection | 52.20 | 22.45 | 80 | 13776 | 128238 | 90486353 |
| Foreign body | 51.77 | 22.45 | 18 | 13838 | 2476 | 90612115 |
| Altered state of consciousness | 49.50 | 22.45 | 40 | 13816 | 31492 | 90583099 |
| Immobile | 47.48 | 22.45 | 22 | 13834 | 6376 | 90608215 |
| Prescription drug used without a prescription | 47.10 | 22.45 | 18 | 13838 | 3237 | 90611354 |
| Hypokalaemia | 46.79 | 22.45 | 77 | 13779 | 131039 | 90483552 |
| Pyrexia | 45.91 | 22.45 | 211 | 13645 | 660274 | 89954317 |
| Peripheral swelling | 45.60 | 22.45 | 5 | 13851 | 413101 | 90201490 |
| Arthralgia | 43.96 | 22.45 | 33 | 13823 | 778489 | 89836102 |
| Alopecia | 43.63 | 22.45 | 11 | 13845 | 495060 | 90119531 |
| Drug abuse | 43.26 | 22.45 | 58 | 13798 | 82289 | 90532302 |
| Abdominal discomfort | 41.30 | 22.45 | 11 | 13845 | 477317 | 90137274 |
| Sinusitis | 40.96 | 22.45 | 3 | 13853 | 343085 | 90271506 |
| Joint swelling | 40.43 | 22.45 | 168 | 13688 | 503132 | 90111459 |
| Affect lability | 37.34 | 22.45 | 27 | 13829 | 18036 | 90596555 |
| General physical health deterioration | 37.14 | 22.45 | 129 | 13727 | 354986 | 90259605 |
| Product prescribing error | 36.60 | 22.45 | 33 | 13823 | 30112 | 90584479 |
| Swelling | 35.60 | 22.45 | 10 | 13846 | 419048 | 90195543 |
| Inappropriate antidiuretic hormone secretion | 35.49 | 22.45 | 27 | 13829 | 19478 | 90595113 |
| Drug ineffective | 34.90 | 22.45 | 103 | 13753 | 1384195 | 89230396 |
| Fracture | 34.64 | 22.45 | 28 | 13828 | 22048 | 90592543 |
| Dehydration | 34.14 | 22.45 | 85 | 13771 | 194362 | 90420229 |
| Weight increased | 33.64 | 22.45 | 11 | 13845 | 417916 | 90196675 |
| Nasopharyngitis | 32.27 | 22.45 | 11 | 13845 | 407093 | 90207498 |
| Pelvic fracture | 32.04 | 22.45 | 23 | 13833 | 15196 | 90599395 |
| Balance disorder | 31.94 | 22.45 | 55 | 13801 | 97025 | 90517566 |
| Delirium | 30.33 | 22.45 | 56 | 13800 | 104303 | 90510288 |
| Bursitis | 29.08 | 22.45 | 63 | 13793 | 131591 | 90483000 |
| Restlessness | 28.31 | 22.45 | 31 | 13825 | 35689 | 90578902 |
| Encephalopathy | 27.96 | 22.45 | 35 | 13821 | 46409 | 90568182 |
| Oxygen saturation decreased | 27.93 | 22.45 | 55 | 13801 | 107428 | 90507163 |
| Abdominal rigidity | 26.29 | 22.45 | 11 | 13845 | 2501 | 90612090 |
| Blister | 25.92 | 22.45 | 4 | 13852 | 254994 | 90359597 |
| Paraesthesia | 25.28 | 22.45 | 4 | 13852 | 250322 | 90364269 |
| Electrolyte imbalance | 24.98 | 22.45 | 24 | 13832 | 23721 | 90590870 |
| Bedridden | 24.75 | 22.45 | 18 | 13838 | 12130 | 90602461 |
| Psoriatic arthropathy | 24.58 | 22.45 | 3 | 13853 | 228332 | 90386259 |
| Pruritus | 24.55 | 22.45 | 28 | 13828 | 541497 | 90073094 |
| Fall | 24.37 | 22.45 | 141 | 13715 | 481669 | 90132922 |
| Depression | 24.02 | 22.45 | 8 | 13848 | 300593 | 90313998 |
| Asthenia | 23.76 | 22.45 | 28 | 13828 | 533723 | 90080868 |
| Retching | 23.31 | 22.45 | 21 | 13835 | 19138 | 90595453 |
| Chest pain | 23.06 | 22.45 | 10 | 13846 | 319635 | 90294956 |
| Product dose omission issue | 22.90 | 22.45 | 8 | 13848 | 291679 | 90322912 |
| Paraneoplastic rash | 22.55 | 22.45 | 5 | 13851 | 128 | 90614463 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Appendicolith | 437.31 | 19.43 | 163 | 13241 | 13293 | 42594638 |
| Appendicitis | 389.54 | 19.43 | 169 | 13235 | 20444 | 42587487 |
| Blood phosphorus increased | 308.20 | 19.43 | 124 | 13280 | 12401 | 42595530 |
| Ventricular fibrillation | 302.59 | 19.43 | 160 | 13244 | 29963 | 42577968 |
| General physical health deterioration | 280.39 | 19.43 | 288 | 13116 | 150958 | 42456973 |
| Cardiogenic shock | 280.07 | 19.43 | 161 | 13243 | 35479 | 42572452 |
| Abdominal distension | 260.17 | 19.43 | 200 | 13204 | 71535 | 42536396 |
| Ascites | 243.49 | 19.43 | 175 | 13229 | 56503 | 42551428 |
| Stress | 243.13 | 19.43 | 159 | 13245 | 44053 | 42563878 |
| Myasthenia gravis | 206.49 | 19.43 | 101 | 13303 | 16036 | 42591895 |
| Hyponatraemia | 201.91 | 19.43 | 201 | 13203 | 101261 | 42506670 |
| Blood uric acid increased | 186.11 | 19.43 | 93 | 13311 | 15454 | 42592477 |
| Multiple organ dysfunction syndrome | 170.80 | 19.43 | 180 | 13224 | 96855 | 42511076 |
| Dry mouth | 168.54 | 19.43 | 122 | 13282 | 39757 | 42568174 |
| Hyperphosphataemia | 168.17 | 19.43 | 82 | 13322 | 12922 | 42595009 |
| Blood cholesterol increased | 156.30 | 19.43 | 100 | 13304 | 26641 | 42581290 |
| Incorrect route of product administration | 144.80 | 19.43 | 92 | 13312 | 24213 | 42583718 |
| Abdominal pain | 144.52 | 19.43 | 233 | 13171 | 190238 | 42417693 |
| Constipation | 136.19 | 19.43 | 208 | 13196 | 162083 | 42445848 |
| Iron deficiency | 131.87 | 19.43 | 66 | 13338 | 10995 | 42596936 |
| Hypophosphataemia | 131.57 | 19.43 | 82 | 13322 | 20863 | 42587068 |
| Bacterial infection | 130.94 | 19.43 | 91 | 13313 | 27788 | 42580143 |
| Sleep disorder therapy | 128.36 | 19.43 | 56 | 13348 | 6838 | 42601093 |
| Neuralgia | 123.46 | 19.43 | 85 | 13319 | 25562 | 42582369 |
| Drug therapy | 116.11 | 19.43 | 51 | 13353 | 6329 | 42601602 |
| Diabetes mellitus | 104.74 | 19.43 | 111 | 13293 | 59976 | 42547955 |
| Sepsis | 96.60 | 19.43 | 201 | 13203 | 199133 | 42408798 |
| Somnolence | 92.67 | 19.43 | 162 | 13242 | 140943 | 42466988 |
| Vomiting | 91.36 | 19.43 | 247 | 13157 | 289476 | 42318455 |
| Swelling | 74.43 | 19.43 | 89 | 13315 | 54796 | 42553135 |
| Thrombosis | 66.21 | 19.43 | 94 | 13310 | 68417 | 42539514 |
| Chronic obstructive pulmonary disease | 66.08 | 19.43 | 90 | 13314 | 63024 | 42544907 |
| Intentional product misuse | 65.92 | 19.43 | 89 | 13315 | 61811 | 42546120 |
| Antacid therapy | 64.74 | 19.43 | 31 | 13373 | 4686 | 42603245 |
| Aortic stenosis | 64.58 | 19.43 | 38 | 13366 | 8707 | 42599224 |
| Nausea | 63.19 | 19.43 | 269 | 13135 | 396530 | 42211401 |
| Sleep disorder | 61.96 | 19.43 | 76 | 13328 | 48019 | 42559912 |
| Bacteroides infection | 61.47 | 19.43 | 25 | 13379 | 2562 | 42605369 |
| Anticoagulant therapy | 56.81 | 19.43 | 28 | 13376 | 4507 | 42603424 |
| Drug intolerance | 56.19 | 19.43 | 95 | 13309 | 80329 | 42527602 |
| Drug ineffective | 54.92 | 19.43 | 71 | 13333 | 630126 | 41977805 |
| Activated partial thromboplastin time prolonged | 54.57 | 19.43 | 43 | 13361 | 15860 | 42592071 |
| End stage renal disease | 50.94 | 19.43 | 42 | 13362 | 16516 | 42591415 |
| Ulcer | 49.11 | 19.43 | 41 | 13363 | 16400 | 42591531 |
| Anaemia | 47.61 | 19.43 | 194 | 13210 | 280084 | 42327847 |
| Drug hypersensitivity | 42.02 | 19.43 | 95 | 13309 | 99294 | 42508637 |
| Dehiscence | 41.27 | 19.43 | 13 | 13391 | 633 | 42607298 |
| Total lung capacity decreased | 38.74 | 19.43 | 20 | 13384 | 3550 | 42604381 |
| Fatigue | 35.89 | 19.43 | 51 | 13353 | 435590 | 42172341 |
| Pulmonary embolism | 34.56 | 19.43 | 99 | 13305 | 119513 | 42488418 |
| Hyperlipidaemia | 34.38 | 19.43 | 38 | 13366 | 21478 | 42586453 |
| Troponin increased | 32.78 | 19.43 | 35 | 13369 | 19027 | 42588904 |
| Gout | 32.40 | 19.43 | 42 | 13362 | 28013 | 42579918 |
| Blood calcium increased | 31.48 | 19.43 | 24 | 13380 | 8430 | 42599501 |
| Lung opacity | 27.25 | 19.43 | 19 | 13385 | 5818 | 42602113 |
| Rash | 26.33 | 19.43 | 29 | 13375 | 276925 | 42331006 |
| Toxicity to various agents | 25.27 | 19.43 | 21 | 13383 | 229115 | 42378816 |
| Condition aggravated | 25.25 | 19.43 | 154 | 13250 | 260600 | 42347331 |
| Arthralgia | 24.95 | 19.43 | 17 | 13387 | 205221 | 42402710 |
| Cholestatic liver injury | 24.49 | 19.43 | 15 | 13389 | 3694 | 42604237 |
| Abdominal neoplasm | 24.25 | 19.43 | 8 | 13396 | 452 | 42607479 |
| Ileus | 24.23 | 19.43 | 30 | 13374 | 19109 | 42588822 |
| Bronchopulmonary aspergillosis allergic | 23.91 | 19.43 | 16 | 13388 | 4582 | 42603349 |
| Analgesic therapy | 23.15 | 19.43 | 18 | 13386 | 6506 | 42601425 |
| Blood test abnormal | 22.73 | 19.43 | 24 | 13380 | 12882 | 42595049 |
| Neuropathy peripheral | 19.74 | 19.43 | 4 | 13400 | 101849 | 42506082 |
| Faecaloma | 19.48 | 19.43 | 16 | 13388 | 6254 | 42601677 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Appendicolith | 498.20 | 19.75 | 169 | 25713 | 14086 | 110549331 |
| Appendicitis | 427.25 | 19.75 | 182 | 25700 | 28282 | 110535135 |
| Blood phosphorus increased | 336.07 | 19.75 | 131 | 25751 | 16209 | 110547208 |
| Ventricular fibrillation | 321.81 | 19.75 | 168 | 25714 | 41145 | 110522272 |
| Hyponatraemia | 294.85 | 19.75 | 306 | 25576 | 217347 | 110346070 |
| Ascites | 282.06 | 19.75 | 207 | 25675 | 92601 | 110470816 |
| Cardiogenic shock | 270.46 | 19.75 | 168 | 25714 | 57170 | 110506247 |
| General physical health deterioration | 257.68 | 19.75 | 400 | 25482 | 424895 | 110138522 |
| Constipation | 229.97 | 19.75 | 346 | 25536 | 357440 | 110205977 |
| Myasthenia gravis | 228.35 | 19.75 | 108 | 25774 | 21403 | 110542014 |
| Blood uric acid increased | 207.01 | 19.75 | 101 | 25781 | 21428 | 110541989 |
| Abdominal distension | 199.81 | 19.75 | 225 | 25657 | 174878 | 110388539 |
| Hyperphosphataemia | 198.01 | 19.75 | 90 | 25792 | 16291 | 110547126 |
| Multiple organ dysfunction syndrome | 176.57 | 19.75 | 197 | 25685 | 151513 | 110411904 |
| Stress | 175.60 | 19.75 | 166 | 25716 | 105182 | 110458235 |
| Intentional product misuse | 174.63 | 19.75 | 184 | 25698 | 132720 | 110430697 |
| Sleep disorder therapy | 164.64 | 19.75 | 63 | 25819 | 7408 | 110556009 |
| Hypophosphataemia | 153.32 | 19.75 | 96 | 25786 | 33086 | 110530331 |
| Drug therapy | 151.82 | 19.75 | 59 | 25823 | 7232 | 110556185 |
| Iron deficiency | 137.73 | 19.75 | 73 | 25809 | 18403 | 110545014 |
| Temperature regulation disorder | 134.89 | 19.75 | 64 | 25818 | 12762 | 110550655 |
| Bacterial infection | 133.73 | 19.75 | 100 | 25782 | 45936 | 110517481 |
| Sepsis | 130.08 | 19.75 | 256 | 25626 | 327090 | 110236327 |
| Neuralgia | 116.24 | 19.75 | 94 | 25788 | 48384 | 110515033 |
| Diabetes mellitus | 113.76 | 19.75 | 128 | 25754 | 99253 | 110464164 |
| Food allergy | 113.56 | 19.75 | 66 | 25816 | 19882 | 110543535 |
| Foetal death | 112.87 | 19.75 | 61 | 25821 | 15984 | 110547433 |
| Abdominal pain | 111.60 | 19.75 | 317 | 25565 | 512672 | 110050745 |
| Incorrect route of product administration | 104.89 | 19.75 | 100 | 25782 | 63961 | 110499456 |
| Somnolence | 104.36 | 19.75 | 221 | 25661 | 297228 | 110266189 |
| Creatinine renal clearance increased | 92.36 | 19.75 | 34 | 25848 | 3591 | 110559826 |
| Antacid therapy | 88.68 | 19.75 | 37 | 25845 | 5447 | 110557970 |
| Anticoagulant therapy | 79.46 | 19.75 | 34 | 25848 | 5327 | 110558090 |
| Ileus | 78.81 | 19.75 | 62 | 25820 | 30667 | 110532750 |
| Altered state of consciousness | 77.79 | 19.75 | 81 | 25801 | 57545 | 110505872 |
| Renal function test abnormal | 77.18 | 19.75 | 39 | 25843 | 8907 | 110554510 |
| Aortic stenosis | 76.44 | 19.75 | 44 | 25838 | 13015 | 110550402 |
| Vomiting | 76.15 | 19.75 | 416 | 25466 | 910259 | 109653158 |
| Immunodeficiency | 75.99 | 19.75 | 67 | 25815 | 38771 | 110524646 |
| Cholestatic liver injury | 75.10 | 19.75 | 36 | 25846 | 7340 | 110556077 |
| Anaemia | 74.82 | 19.75 | 289 | 25593 | 546797 | 110016620 |
| Urinary retention | 68.45 | 19.75 | 83 | 25799 | 69600 | 110493817 |
| Head discomfort | 68.31 | 19.75 | 47 | 25835 | 18953 | 110544464 |
| Listless | 68.13 | 19.75 | 29 | 25853 | 4486 | 110558931 |
| Activated partial thromboplastin time prolonged | 68.11 | 19.75 | 50 | 25832 | 22318 | 110541099 |
| Reduced facial expression | 67.10 | 19.75 | 27 | 25855 | 3624 | 110559793 |
| Creatinine renal clearance decreased | 66.96 | 19.75 | 49 | 25833 | 21766 | 110541651 |
| Bacteroides infection | 65.69 | 19.75 | 25 | 25857 | 2894 | 110560523 |
| End stage renal disease | 65.38 | 19.75 | 48 | 25834 | 21425 | 110541992 |
| Thrombosis | 65.22 | 19.75 | 102 | 25780 | 108560 | 110454857 |
| Sedation complication | 64.13 | 19.75 | 46 | 25836 | 19809 | 110543608 |
| Peripheral swelling | 62.23 | 19.75 | 10 | 25872 | 404024 | 110159393 |
| Drug ineffective | 61.70 | 19.75 | 169 | 25713 | 1520371 | 109043046 |
| Chronic obstructive pulmonary disease | 60.76 | 19.75 | 99 | 25783 | 109059 | 110454358 |
| Multiple drug therapy | 60.67 | 19.75 | 32 | 25850 | 7982 | 110555435 |
| Cognitive disorder | 59.41 | 19.75 | 87 | 25795 | 87424 | 110475993 |
| Sinusitis | 57.10 | 19.75 | 3 | 25879 | 296685 | 110266732 |
| Coeliac disease | 57.02 | 19.75 | 60 | 25822 | 43127 | 110520290 |
| Nausea | 56.24 | 19.75 | 486 | 25396 | 1235204 | 109328213 |
| Overdose | 56.16 | 19.75 | 150 | 25732 | 233644 | 110329773 |
| Arthralgia | 54.91 | 19.75 | 61 | 25821 | 779571 | 109783846 |
| Decreased immune responsiveness | 52.60 | 19.75 | 31 | 25851 | 9575 | 110553842 |
| Dry mouth | 49.76 | 19.75 | 130 | 25752 | 199818 | 110363599 |
| Apathy | 48.76 | 19.75 | 36 | 25846 | 16203 | 110547214 |
| Weight increased | 48.12 | 19.75 | 19 | 25863 | 419625 | 110143792 |
| Blood calcium decreased | 47.68 | 19.75 | 50 | 25832 | 35795 | 110527622 |
| Total lung capacity decreased | 47.13 | 19.75 | 26 | 25856 | 7088 | 110556329 |
| Abdominal discomfort | 46.55 | 19.75 | 17 | 25865 | 393841 | 110169576 |
| Therapeutic product effect decreased | 45.39 | 19.75 | 3 | 25879 | 244313 | 110319104 |
| Alopecia | 44.38 | 19.75 | 15 | 25867 | 364738 | 110198679 |
| Gout | 43.36 | 19.75 | 48 | 25834 | 36518 | 110526899 |
| Pyrexia | 43.23 | 19.75 | 358 | 25524 | 897907 | 109665510 |
| Paraesthesia | 42.21 | 19.75 | 7 | 25875 | 276514 | 110286903 |
| Upper respiratory tract infection | 41.89 | 19.75 | 94 | 25788 | 131234 | 110432183 |
| Amaurosis fugax | 41.61 | 19.75 | 17 | 25865 | 2373 | 110561044 |
| Hyperlipidaemia | 40.69 | 19.75 | 46 | 25836 | 35802 | 110527615 |
| Troponin increased | 40.45 | 19.75 | 42 | 25840 | 29724 | 110533693 |
| Prescribed overdose | 40.27 | 19.75 | 73 | 25809 | 87508 | 110475909 |
| Hypokalaemia | 39.77 | 19.75 | 113 | 25769 | 182335 | 110381082 |
| Dehiscence | 38.75 | 19.75 | 12 | 25870 | 746 | 110562671 |
| Foreign body | 37.91 | 19.75 | 17 | 25865 | 2978 | 110560439 |
| Immobile | 37.38 | 19.75 | 23 | 25859 | 7679 | 110555738 |
| Rash erythematous | 37.36 | 19.75 | 68 | 25814 | 81764 | 110481653 |
| Ulcer | 36.98 | 19.75 | 48 | 25834 | 43068 | 110520349 |
| Depressed level of consciousness | 35.40 | 19.75 | 80 | 25802 | 112198 | 110451219 |
| Orthostatic hypotension | 35.39 | 19.75 | 59 | 25823 | 66190 | 110497227 |
| Memory impairment | 34.93 | 19.75 | 3 | 25879 | 196941 | 110366476 |
| Psoriatic arthropathy | 34.89 | 19.75 | 3 | 25879 | 196758 | 110366659 |
| Blood cholesterol increased | 34.17 | 19.75 | 108 | 25774 | 184677 | 110378740 |
| Fluid retention | 34.07 | 19.75 | 71 | 25811 | 94236 | 110469181 |
| Pain in extremity | 33.28 | 19.75 | 39 | 25843 | 487079 | 110076338 |
| Lung opacity | 33.13 | 19.75 | 25 | 25857 | 11627 | 110551790 |
| Blood calcium increased | 33.06 | 19.75 | 30 | 25852 | 18010 | 110545407 |
| Urinary tract disorder | 32.37 | 19.75 | 19 | 25863 | 5825 | 110557592 |
| Pulmonary embolism | 31.45 | 19.75 | 116 | 25766 | 214358 | 110349059 |
| Sleep disorder | 31.31 | 19.75 | 110 | 25772 | 198534 | 110364883 |
| Blister | 30.10 | 19.75 | 8 | 25874 | 227368 | 110336049 |
| Faecaloma | 29.72 | 19.75 | 26 | 25856 | 14882 | 110548535 |
| Depression | 29.43 | 19.75 | 19 | 25863 | 317316 | 110246101 |
| Drug interaction | 29.37 | 19.75 | 209 | 25673 | 499974 | 110063443 |
| Analgesic therapy | 28.52 | 19.75 | 19 | 25863 | 7265 | 110556152 |
| Prescription drug used without a prescription | 28.18 | 19.75 | 17 | 25865 | 5479 | 110557938 |
| Inappropriate antidiuretic hormone secretion | 27.96 | 19.75 | 37 | 25845 | 33814 | 110529603 |
| Malaise | 27.60 | 19.75 | 74 | 25808 | 671745 | 109891672 |
| Therapeutic product effect incomplete | 27.56 | 19.75 | 9 | 25873 | 223796 | 110339621 |
| Musculoskeletal pain | 27.12 | 19.75 | 5 | 25877 | 183018 | 110380399 |
| Urticaria | 27.05 | 19.75 | 21 | 25861 | 318836 | 110244581 |
| Chest pain | 26.93 | 19.75 | 29 | 25853 | 376346 | 110187071 |
| Delirium | 26.89 | 19.75 | 81 | 25801 | 134944 | 110428473 |
| Fatigue | 26.73 | 19.75 | 171 | 25711 | 1215787 | 109347630 |
| Nasopharyngitis | 26.47 | 19.75 | 32 | 25850 | 394329 | 110169088 |
| Therapy non-responder | 26.32 | 19.75 | 3 | 25879 | 157304 | 110406113 |
| Product dose omission issue | 26.29 | 19.75 | 22 | 25860 | 321760 | 110241657 |
| Folliculitis | 26.13 | 19.75 | 4 | 25878 | 167649 | 110395768 |
| Wheezing | 25.46 | 19.75 | 14 | 25868 | 255216 | 110308201 |
| Osteoarthritis | 24.99 | 19.75 | 6 | 25876 | 182617 | 110380800 |
| Affect lability | 24.79 | 19.75 | 26 | 25856 | 18611 | 110544806 |
| Sedation | 24.63 | 19.75 | 52 | 25830 | 69631 | 110493786 |
| Pneumonia aspiration | 24.63 | 19.75 | 57 | 25825 | 81176 | 110482241 |
| Injection site pain | 24.04 | 19.75 | 6 | 25876 | 177916 | 110385501 |
| Arthritis | 23.95 | 19.75 | 5 | 25877 | 167581 | 110395836 |
| Ill-defined disorder | 23.86 | 19.75 | 4 | 25878 | 156849 | 110406568 |
| Hypoaesthesia | 23.86 | 19.75 | 23 | 25859 | 314200 | 110249217 |
| Bronchopulmonary aspergillosis allergic | 23.78 | 19.75 | 18 | 25864 | 8408 | 110555009 |
| Congenital hiatus hernia | 23.72 | 19.75 | 16 | 25866 | 6243 | 110557174 |
| Benign prostatic hyperplasia | 23.47 | 19.75 | 25 | 25857 | 18209 | 110545208 |
| pH body fluid increased | 23.08 | 19.75 | 5 | 25877 | 73 | 110563344 |
| Pelvic fracture | 22.97 | 19.75 | 22 | 25860 | 14132 | 110549285 |
| Thrombocytopenia | 22.97 | 19.75 | 150 | 25732 | 348735 | 110214682 |
| Dyspepsia | 22.96 | 19.75 | 8 | 25874 | 190957 | 110372460 |
| Intentional product use issue | 22.76 | 19.75 | 15 | 25867 | 247891 | 110315526 |
| Product prescribing error | 22.60 | 19.75 | 42 | 25840 | 51289 | 110512128 |
| Pruritus | 22.43 | 19.75 | 66 | 25816 | 581494 | 109981923 |
| Drug intolerance | 22.20 | 19.75 | 167 | 25715 | 406345 | 110157072 |
| Fall | 22.09 | 19.75 | 227 | 25655 | 603255 | 109960162 |
| Fracture | 21.89 | 19.75 | 28 | 25854 | 24760 | 110538657 |
| Blood test abnormal | 21.74 | 19.75 | 30 | 25852 | 28524 | 110534893 |
| Hyperhidrosis | 21.59 | 19.75 | 94 | 25788 | 187204 | 110376213 |
| Liver function test increased | 21.42 | 19.75 | 57 | 25825 | 88491 | 110474926 |
| Systemic infection | 21.35 | 19.75 | 18 | 25864 | 9801 | 110553616 |
| Heart rate increased | 21.16 | 19.75 | 4 | 25878 | 143830 | 110419587 |
| Asthenia | 20.68 | 19.75 | 87 | 25795 | 688912 | 109874505 |
| Abdominal rigidity | 20.48 | 19.75 | 12 | 25870 | 3668 | 110559749 |
| Gait disturbance | 20.39 | 19.75 | 21 | 25861 | 278187 | 110285230 |
| Hepatic function abnormal | 20.12 | 19.75 | 56 | 25826 | 89239 | 110474178 |
| Maternal exposure during pregnancy | 20.12 | 19.75 | 18 | 25864 | 254865 | 110308552 |
None
| Source | Code | Description |
|---|---|---|
| ATC | A06AB08 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
| ATC | A06AB58 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
| MeSH PA | D002400 | Cathartics |
| MeSH PA | D005765 | Gastrointestinal Agents |
| CHEBI has role | CHEBI:50503 | laxative |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Colonoscopy | indication | 73761001 |
None
None
None
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 12GM/BOT;3.5GM/BOT;10MG/BOT | CLENPIQ | FERRING PHARMS INC | N209589 | Nov. 28, 2017 | RX | SOLUTION | ORAL | 11191753 | June 23, 2034 | FOR CLEANSING OF THE COLON AS A PREPARATION FOR COLONOSCOPY |
| 12GM/BOT;3.5GM/BOT;10MG/BOT | CLENPIQ | FERRING PHARMS INC | N209589 | Nov. 28, 2017 | RX | SOLUTION | ORAL | 12576072 | June 23, 2034 | FOR CLEANSING OF THE COLON AS A PREPARATION FOR COLONOSCOPY |
| 12GM/BOT;3.5GM/BOT;10MG/BOT | CLENPIQ | FERRING PHARMS INC | N209589 | Nov. 28, 2017 | RX | SOLUTION | ORAL | 9827231 | June 26, 2034 | FOR CLEANSING THE LARGE INTESTINE AS A PREPARATION FOR COLONOSCOPY |
None
None
| ID | Source |
|---|---|
| LR57574HN8 | UNII |
| 4032318 | VUID |
| N0000186955 | NUI |
| 4032318 | VANDF |
| C0071042 | UMLSCUI |
| CHEBI:32147 | CHEBI |
| CHEMBL1697768 | ChEMBL_ID |
| 68654 | PUBCHEM_CID |
| C005701 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB14232 | DRUGBANK_ID |
| 33688 | RXNORM |
| 18056 | MMSL |
| d04939 | MMSL |
| 003762 | NDDF |
| 317558003 | SNOMEDCT_US |
| 395881001 | SNOMEDCT_US |
| C0058139 | UMLSCUI |
| 69046 | PUBCHEM_CID |
| 1307301-38-7 | SECONDARY_CAS_RN |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| SODIUM PICOSULFATE, MAGNESIUM OXIDE AND ANHYDROUS CITRIC ACID | HUMAN PRESCRIPTION DRUG LABEL | 3 | 31722-874 | POWDER, METERED | 10 mg | ORAL | ANDA | 25 sections |
| CLENPIQ | HUMAN PRESCRIPTION DRUG LABEL | 3 | 55566-6800 | LIQUID | 10 mg | ORAL | NDA | 31 sections |