oxyphenisatine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2038 125-13-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxyphenisatin
  • oxyphenisatine
  • phenolisatin
  • veripaque
  • Molecular weight: 317.34
  • Formula: C20H15NO3
  • CLOGP: 2.49
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 69.56
  • ALOGS: -4.40
  • ROTB: 2

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.808 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 4.169 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 20.606 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 23.878 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 3.090 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 8.960 % High 1
herg hERG pIC50 4.733 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 10.864 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 4.426 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 2.890 % High 1
kinase-safety-class ACVR2B,EIF2AK3,GRK2,PDK1,PDK2,PDK4 6
kinase-selectivity-class GRK2 1
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 13.062 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 11.015 High 1
mh-clint Mouse hepatocyte intrinsic clearance 73.790 High 1
mppb Mouse plasma protein binding (% unbound) 2.700 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 18.621 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 3.430 % High 1
rat-kpuu-brain Rat brain Kpuu 0.026 % High 1
rh-clint Rat hepatocyte intrinsic clearance 86.896 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 32.470 % High 1
rppb Rat plasma protein binding (% unbound) 2.480 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 217.771 uM High 1

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A06AB01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Contact laxatives
MeSH PA D002400 Cathartics
MeSH PA D005765 Gastrointestinal Agents
CHEBI has role CHEBI:50503 laxative

Related Drugs by ATC class:

A06AB Contact laxatives 6 drugs
bisacodylbisoxatincastor oildantronphenolphthaleinsodium picosulfate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.12 acidic
pKa2 9.72 acidic
pKa3 10.07 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D08326 KEGG_DRUG
CHEBI:135358 CHEBI
CHEMBL245807 ChEMBL_ID
CHEMBL1402684 ChEMBL_ID
DB04823 DRUGBANK_ID
225825 RXNORM
004457 NDDF
346604000 SNOMEDCT_US
C0031422 UMLSCUI
D010114 MESH_DESCRIPTOR_UI
31315 PUBCHEM_CID
774 INN_ID
3BT0VQG2GQ UNII

Pharmaceutical products:

None