All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

castor oil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	5661	8001-79-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: castor oil	Molecular weight: 933.45 Formula: C57H104O9 CLOGP: 12 LIPINSKI: 2 HAC: 9 HDO: 3 TPSA: 139.59 ALOGS: -7.41 ROTB: 53

Drug dosage:

Dose	Unit	Route
20	g	O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70	54
kinase-selectivity-class	AXL,CDK4,EIF2AK3,EPHB4,GRK2,MAP2K6,PDK4,PLK1,STK33,TEK	10
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	1210.59	33.99	345	8994	37625	90581483
Chronic sinusitis	541.78	33.99	167	9172	23635	90595473
Paraesthesia oral	436.35	33.99	152	9187	31507	90587601
Vaginal flatulence	402.29	33.99	115	9224	12523	90606585
Sedation complication	381.65	33.99	118	9221	16826	90602282
Proctitis	380.88	33.99	115	9224	15144	90603964
Creatinine renal clearance decreased	377.21	33.99	120	9219	18779	90600329
Constipation	374.51	33.99	274	9065	280121	90338987
Female genital tract fistula	371.31	33.99	117	9222	17751	90601357
Procedural pain	364.89	33.99	135	9204	33225	90585883
Radiculopathy	359.03	33.99	115	9224	18390	90600718
Vaginal discharge	353.32	33.99	115	9224	19349	90599759
Blood calcium decreased	318.52	33.99	119	9220	30063	90589045
Oral candidiasis	285.98	33.99	115	9224	35340	90583768
Orthostatic hypotension	280.88	33.99	119	9220	41708	90577400
Sedation	267.91	33.99	120	9219	48051	90571057
Depressed level of consciousness	246.29	33.99	129	9210	72655	90546453
Colitis	239.61	33.99	125	9214	69817	90549291
Frequent bowel movements	236.69	33.99	116	9223	56819	90562289
Colitis ulcerative	233.38	33.99	117	9222	60149	90558959
Cognitive disorder	231.93	33.99	122	9217	69285	90549823
Haematochezia	226.64	33.99	121	9218	70792	90548316
Rectal haemorrhage	203.86	33.99	119	9220	82625	90536483
Therapeutic product effect incomplete	193.91	33.99	160	9179	193736	90425372
Balance disorder	191.30	33.99	121	9218	96959	90522149
Renal function test abnormal	165.69	33.99	51	9288	7140	90611968
Creatinine renal clearance increased	160.96	33.99	42	9297	3239	90615869
Dyspepsia	154.60	33.99	142	9197	198018	90421090
Erythema	129.90	33.99	138	9201	229108	90390000
Drug ineffective	119.45	33.99	361	8978	1383937	89235171
Weight decreased	118.23	33.99	169	9170	379741	90239367
Abdominal pain	110.08	33.99	167	9172	395554	90223554
Pain	105.30	33.99	280	9059	996061	89623047
Multiple drug therapy	101.61	33.99	35	9304	6974	90612134
Mobility decreased	93.70	33.99	122	9217	250612	90368496
Anaemia	87.06	33.99	141	9198	352661	90266447
Toxicity to various agents	79.23	33.99	121	9218	287725	90331383
Malaise	77.76	33.99	180	9159	585806	90033302
Hypotension	77.48	33.99	128	9211	325269	90293839
Pyrexia	73.92	33.99	190	9149	660295	89958813
Infusion related reaction	70.08	33.99	141	9198	416639	90202469
Off label use	57.08	33.99	244	9095	1102008	89517100
Fatigue	55.41	33.99	25	9314	1153998	89465110
Condition aggravated	46.62	33.99	4	9335	595541	90023567
Drug abuse	45.49	33.99	49	9290	82298	90536810
Fall	45.13	33.99	130	9209	481680	90137428
Rash	36.96	33.99	18	9321	796082	89823026
Joint swelling	35.29	33.99	5	9334	503295	90115813
Abdominal discomfort	35.26	33.99	4	9335	477324	90141784
Overdose	34.72	33.99	60	9279	157649	90461459

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Injection related reaction	57.84	22.29	12	2466	604	42618253
Volvulus	34.62	22.29	10	2468	2003	42616854
Skin reaction	32.35	22.29	13	2465	7054	42611803
Oesophageal injury	30.95	22.29	6	2472	213	42618644
Pneumonia aspiration	25.48	22.29	22	2456	50056	42568801

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Chronic sinusitis	526.73	25.82	165	11079	24919	110553136
Macular degeneration	511.89	25.82	156	11088	21503	110556552
Paraesthesia oral	421.38	25.82	150	11094	33521	110544534
Vaginal flatulence	403.69	25.82	114	11130	12030	110566025
Female genital tract fistula	377.53	25.82	116	11128	16403	110561652
Proctitis	374.74	25.82	116	11128	16811	110561244
Sedation complication	372.84	25.82	120	11124	19735	110558320
Creatinine renal clearance decreased	369.76	25.82	122	11122	21693	110556362
Constipation	368.19	25.82	298	10946	357488	110220567
Vaginal discharge	359.99	25.82	114	11130	17794	110560261
Procedural pain	354.45	25.82	134	11110	35431	110542624
Radiculopathy	351.39	25.82	114	11130	19222	110558833
Blood calcium decreased	317.65	25.82	124	11120	35721	110542334
Oral candidiasis	264.74	25.82	116	11128	44644	110533411
Orthostatic hypotension	241.62	25.82	123	11121	66126	110511929
Sedation	232.89	25.82	122	11122	69561	110508494
Cognitive disorder	214.82	25.82	125	11119	87386	110490669
Depressed level of consciousness	213.07	25.82	136	11108	112142	110465913
Frequent bowel movements	210.49	25.82	115	11129	71275	110506780
Colitis ulcerative	204.55	25.82	116	11128	77247	110500808
Colitis	196.76	25.82	125	11119	102198	110475857
Balance disorder	186.66	25.82	127	11117	116433	110461622
Haematochezia	182.92	25.82	125	11119	115399	110462656
Therapeutic product effect incomplete	175.66	25.82	160	11084	223645	110354410
Rectal haemorrhage	162.61	25.82	118	11126	119715	110458340
Creatinine renal clearance increased	157.35	25.82	42	11202	3583	110574472
Dyspepsia	156.64	25.82	140	11104	190825	110387230
Renal function test abnormal	155.38	25.82	51	11193	8895	110569160
Erythema	133.46	25.82	156	11088	291291	110286764
Pain	120.58	25.82	285	10959	954670	109623385
Weight decreased	109.18	25.82	181	11063	467876	110110179
Multiple drug therapy	108.89	25.82	38	11206	7976	110570079
Mobility decreased	108.48	25.82	127	11117	237295	110340760
Abdominal pain	95.86	25.82	180	11064	512809	110065246
Infusion related reaction	86.92	25.82	146	11098	381016	110197039
Anaemia	78.40	25.82	172	11072	546914	110031141
Pyrexia	69.09	25.82	224	11020	898041	109680014
Malaise	67.24	25.82	184	11060	671635	109906420
Hypotension	53.86	25.82	145	11099	523704	110054351
Toxicity to various agents	51.40	25.82	135	11109	480420	110097635
Fatigue	44.82	25.82	35	11209	1215923	109362132
Fall	41.37	25.82	145	11099	603337	109974718
Injection related reaction	39.94	25.82	12	11232	1566	110576489
Nausea	33.99	25.82	228	11016	1235462	109342593
Off label use	31.72	25.82	260	10984	1499925	109078130
Condition aggravated	31.24	25.82	18	11226	734818	109843237
Overdose	28.39	25.82	69	11175	233725	110344330
Weight increased	27.01	25.82	5	11239	419639	110158416
Arthralgia	26.73	25.82	24	11220	779608	109798447

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A06AB05	ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives
MeSH PA	D002400	Cathartics
MeSH PA	D005765	Gastrointestinal Agents
CHEBI has role	CHEBI:50503	laxative
CHEBI has role	CHEBI:75325	cathartic

Related Drugs by ATC class:

A06AB Contact laxatives 6 drugs

bisacodylbisoxatindantronoxyphenisatinephenolphthaleinsodium picosulfate

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

Species	Use	Relation
Multiple Species	External wounds	Indication
Multiple Species	Removal of necrotic tissue, exudate and organic debris	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Trypzyme Aerosol	Farnam Companies Inc.	3
Granulex V	Mylan Institutional Inc.	3

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
CHEMBL2109005	ChEMBL_ID
DB11113	DRUGBANK_ID
34239008	SNOMEDCT_US
774188002	SNOMEDCT_US
4008463	VANDF
4024405	VANDF
C0007343	UMLSCUI
D002368	MESH_DESCRIPTOR_UI
D06462	KEGG_DRUG
4367	MMSL
5344	MMSL
d01014	MMSL
001177	NDDF
002478	NDDF
008584	NDDF
D5340Y2I9G	UNII
2129	RXNORM

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Well at Walgreens Castor Oil	HUMAN OTC DRUG LABEL	1	0363-0078	OIL	1 g	ORAL	OTC Monograph Drug	16 sections
Well at Walgreens Castor Oil	HUMAN OTC DRUG LABEL	1	0363-0078	OIL	1 g	ORAL	OTC Monograph Drug	16 sections
Humco Castor Oil (Regular)	HUMAN OTC DRUG LABEL	1	0395-0513	LIQUID	1 mg	ORAL	OTC Monograph Drug	12 sections
Humco Castor Oil	HUMAN OTC DRUG LABEL	1	0395-0515	LIQUID	1 mg	ORAL	OTC Monograph Drug	12 sections
Humco Castor Oil	HUMAN OTC DRUG LABEL	1	0395-9113	LIQUID	1 mg	ORAL	OTC monograph not final	13 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	0869-0078	LIQUID	1 g	ORAL	OTC Monograph Drug	15 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	11344-078	LIQUID	1 g	ORAL	OTC Monograph Drug	15 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	11344-870	LIQUID	1 mg	ORAL	OTC Monograph Drug	15 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	11344-870	LIQUID	1 mL	ORAL	OTC Monograph Drug	15 sections
Rite Aid Castor Oil	HUMAN OTC DRUG LABEL	1	11822-0645	LIQUID	1 mg	ORAL	OTC Monograph Drug	12 sections
Balsamic Liniment	HUMAN OTC DRUG LABEL	2	16638-042	LINIMENT	35.60 g	TOPICAL	OTC monograph not final	9 sections
Signature Care	HUMAN OTC DRUG LABEL	1	21130-078	OIL	1 g	ORAL	OTC Monograph Drug	16 sections
De La Cruz Castor Oil	HUMAN OTC DRUG LABEL	1	24286-1526	OIL	1 g	ORAL	OTC Monograph Drug	15 sections
GNP Castor Oil	HUMAN OTC DRUG LABEL	1	24385-515	LIQUID	1 mg	ORAL	OTC Monograph Drug	12 sections
Top Care Castor Oil	HUMAN OTC DRUG LABEL	1	36800-270	OIL	1 mg	ORAL	OTC Monograph Drug	8 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	36800-952	LIQUID	1 g	ORAL	OTC Monograph Drug	15 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	41163-078	LIQUID	1 mg	ORAL	OTC Monograph Drug	16 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	41163-078	LIQUID	1 mL	ORAL	OTC Monograph Drug	16 sections
DDM Castor Oil	HUMAN OTC DRUG LABEL	1	53943-515	LIQUID	1 mg	ORAL	OTC Monograph Drug	12 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	55910-979	LIQUID	1 mg	ORAL	OTC Monograph Drug	15 sections
Quality Choice Castor Oil	HUMAN OTC DRUG LABEL	1	63868-322	LIQUID	1 mg	ORAL	OTC Monograph Drug	12 sections
Premiere Value Castor Oil	HUMAN OTC DRUG LABEL	1	68016-515	LIQUID	1 mg	ORAL	OTC Monograph Drug	12 sections
Harris Teeter Castor Oil	HUMAN OTC DRUG LABEL	1	69256-515	LIQUID	1 mg	ORAL	OTC Monograph Drug	13 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	69452-487	LIQUID	1 mg	ORAL	OTC Monograph Drug	13 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	69842-978	LIQUID	1 mg	ORAL	OTC Monograph Drug	15 sections
Leader Castor Oil	HUMAN OTC DRUG LABEL	1	70000-0024	OIL	1 g	ORAL	OTC Monograph Drug	16 sections
Foster and Thrive Castor Oil	HUMAN OTC DRUG LABEL	1	70677-1085	LIQUID	1 mg	ORAL	OTC Monograph Drug	12 sections
Castor Oil	HUMAN OTC DRUG LABEL	1	70677-1317	LIQUID	1 mg	ORAL	OTC Monograph Drug	13 sections
CLBiO Cleansing Pack	HUMAN OTC DRUG LABEL	6	70874-0001	SOAP	0.30 g	TOPICAL	unapproved drug other	7 sections
CLBiO Cleansing Pack	HUMAN OTC DRUG LABEL	6	70874-0002	SOAP	0.30 g	TOPICAL	unapproved drug other	7 sections