phenolphthalein 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2135 | 77-09-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An acid-base indicator which is colorless in acid solution, but turns pink to red as the solution becomes alkaline. It is used medicinally as a cathartic.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.20 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A06AB04 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR CONSTIPATION DRUGS FOR CONSTIPATION Contact laxatives |
| MeSH PA | D007202 | Indicators and Reagents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Constipation | off-label use | 14760008 | DOID:2089 |
| Incomplete passage of stool | off-label use | 249515001 | |
| Incontinence of feces | contraindication | 72042002 | |
| Appendicitis | contraindication | 74400008 | DOID:8337 |
| Gastrointestinal obstruction | contraindication | 126765001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.45 | acidic |
| pKa2 | 10.06 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Thymidylate synthase | Enzyme | Ki | 5.92 | CHEMBL | |||||
| Thymidylate synthase | Enzyme | Ki | 5.33 | CHEMBL | |||||
| Thymidylate synthase | Enzyme | Ki | 5.33 | CHEMBL | |||||
| Thymidylate synthase | Enzyme | Ki | 5.85 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4020931 | VUID |
| N0000148413 | NUI |
| D05456 | KEGG_DRUG |
| 4018930 | VANDF |
| 4020338 | VANDF |
| 4020931 | VANDF |
| C0600489 | UMLSCUI |
| CHEBI:34914 | CHEBI |
| FGT | PDB_CHEM_ID |
| CHEMBL63857 | ChEMBL_ID |
| DB04824 | DRUGBANK_ID |
| D020113 | MESH_DESCRIPTOR_UI |
| 4764 | PUBCHEM_CID |
| 4575 | INN_ID |
| 6QK969R2IF | UNII |
| 155122 | RXNORM |
| 5275 | MMSL |
| 71908 | MMSL |
| d01012 | MMSL |
| 001174 | NDDF |
| 19595005 | SNOMEDCT_US |
| 398955002 | SNOMEDCT_US |
Pharmaceutical products:
None