oxametacin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory, indometacin derivatives 2008 27035-30-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxametacin
  • indoxamic acid
  • Molecular weight: 372.81
  • Formula: C19H17ClN2O4
  • CLOGP: 3.11
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 80.56
  • ALOGS: -4.82
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AB13 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme IC50 5.55 CHEMBL
Arachidonate 5-lipoxygenase Enzyme IC50 5.12 CHEMBL
Cyclooxygenase Enzyme IC50 5.96 CHEMBL

External reference:

IDSource
D07266 KEGG_DRUG
8G02RSW5CM UNII
4223 INN_ID
CHEMBL295829 ChEMBL_ID
CHEBI:76255 CHEBI
DB13308 DRUGBANK_ID
33675 PUBCHEM_CID

Pharmaceutical products:

None