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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
oxametacin 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
anti-inflammatory, indometacin derivatives
2008
27035-30-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
oxametacin
indoxamic acid
Molecular weight: 372.81
Formula: C19H17ClN2O4
CLOGP: 3.11
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 80.56
ALOGS: -4.82
ROTB: 4
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
M01AB13
MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
CHEBI has role
CHEBI:35475
non-steroidal anti-inflammatory agent
CHEBI has role
CHEBI:35544
cyclooxygenase inhibitors
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
9.7
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Prostaglandin G/H synthase 1
Enzyme
P23219
PGH1_HUMAN
IC50
5.55
CHEMBL
Arachidonate 5-lipoxygenase
Enzyme
LOX5_RAT
IC50
5.12
CHEMBL
Cyclooxygenase
Enzyme
PGH2_RAT
PGH1_RAT
IC50
5.96
CHEMBL
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External reference:
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ID
Source
33675
PUBCHEM_CID
4223
INN_ID
8G02RSW5CM
UNII
C2698676
UMLSCUI
CHEBI:76255
CHEBI
CHEMBL295829
ChEMBL_ID
D07266
KEGG_DRUG
DB13308
DRUGBANK_ID
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Pharmaceutical products:
None
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oxametacin