oxametacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory, indometacin derivatives 2008 27035-30-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • oxametacin
  • indoxamic acid
  • Molecular weight: 372.81
  • Formula: C19H17ClN2O4
  • CLOGP: 3.11
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 80.56
  • ALOGS: -4.82
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EGFR,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK10,MAPK7,MAPKAPK2,PDK1,PDK2,PDK4,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC,TEK 26
kinase-selectivity-class ACVR2B,AXL,EIF2AK3,PDK4,TTK 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 2.965 Moderate 0.79
pfas-class PFAS structural alert (1 = True, 0 = False) 0
rat-kpuu-brain Rat brain Kpuu 0.136 % Moderate 0.79

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AB13 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor

Related Drugs by ATC class:

M01AB Acetic acid derivatives and related substances 16 drugs
aceclofenacacemetacinalclofenacbufexamacbumadizonediclofenacdifenpiramideetodolacfentiazacindomethacinketorolaclonazolac show all 16 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme IC50 5.55 CHEMBL
Arachidonate 5-lipoxygenase Enzyme IC50 5.12 CHEMBL
Cyclooxygenase Enzyme IC50 5.96 CHEMBL

External reference:

IDSource
D07266 KEGG_DRUG
C2698676 UMLSCUI
CHEBI:76255 CHEBI
CHEMBL295829 ChEMBL_ID
DB13308 DRUGBANK_ID
33675 PUBCHEM_CID
4223 INN_ID
8G02RSW5CM UNII

Pharmaceutical products:

None