difenpiramide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
919 51484-40-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • difenpiramide
  • diphenpyramide
  • difenpiramide sulfate
  • difenpiramide maleate
  • difenpiramide monohydrochloride
  • difenpiramide hydrochloride
  • difenpiramide HCl
non-steroidal anti-inflammatory agent; do not confuse with herbicide diphenamid; RN given refers to parent cpd; structure
  • Molecular weight: 288.35
  • Formula: C19H16N2O
  • CLOGP: 3.92
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 41.99
  • ALOGS: -4.71
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 4.232 Moderate 0.70
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.575 Moderate 0.70
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 35.075 10^-6 cm/s Moderate 0.70
dh-clint Dog hepatocyte intrinsic clearance 52.966 uL/min/10^6 cells Moderate 0.70
dppb Dog plasma protein binding (% unbound) 0.390 % Moderate 0.70
fcs-ppb Fetal calf serum protein binding (% unbound) 1.160 % Moderate 0.70
herg hERG pIC50 4.717 pIC50 Moderate 0.70
hh-clint Human hepatocyte intrinsic clearance 111.173 uL/min/10^6 cells Moderate 0.70
hlm-clint Human liver microsomal intrinsic clearance 73.114 uL/min/mg protein Moderate 0.70
hppb Human plasma protein binding (% unbound) 0.350 % Moderate 0.70
kinase-safety-class ACVR2B,ALK,AXL,BRAF,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,ITK,MAP3K1,MAP3K21,MAPK7,MAPK9,MAPKAPK2,MARK4,PDK1,PDK2,PDK4,PIK3CG,PRKDC,SIK2,SIK3,STK33,TTK 32
kinase-selectivity-class AXL,MAP3K21 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.302 Moderate 0.70
mh-clint Mouse hepatocyte intrinsic clearance 242.103 Moderate 0.70
mppb Mouse plasma protein binding (% unbound) 0.550 Moderate 0.70
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.302 Moderate 0.70
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 1.520 % Moderate 0.70
rh-clint Rat hepatocyte intrinsic clearance 266.686 uL/min/10^6 cells Moderate 0.70
rh-fuinc Rat hepatocyte fraction unbound in incubation 7.010 % Moderate 0.70
rppb Rat plasma protein binding (% unbound) 0.420 % Moderate 0.70
solubility-dd Solubility at pH 7.4 in DMSO 1.081 uM Moderate 0.70

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AB12 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35493 antipyretic

Related Drugs by ATC class:

M01AB Acetic acid derivatives and related substances 16 drugs
aceclofenacacemetacinalclofenacbufexamacbumadizonediclofenacetodolacfentiazacindomethacinketorolaclonazolacoxametacin show all 16 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.27 acidic
pKa2 3.77 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0057982 UMLSCUI
CHEMBL1489662 ChEMBL_ID
DB13371 DRUGBANK_ID
C015136 MESH_SUPPLEMENTAL_RECORD_UI
Q6U5F6E1QL UNII
100472 PUBCHEM_CID
CHEBI:76130 CHEBI

Pharmaceutical products:

None