bumadizone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory analgesics, phenylbutazone derivatives 426 3583-64-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bumadizone
  • bumadizon
  • bumazidone
  • bumadizone calcium
  • bumadizone calcium hydrate
  • bumadizone calcium dihydrate
  • eumotol
  • desflam
an anlgesic, antipyretic and anti-inflammatory agent; minor descriptor (75-86); on line & INDEX MEDICUS search MALONATES (75-86); RN given refers to parent cpd
  • Molecular weight: 326.40
  • Formula: C19H22N2O3
  • CLOGP: 4.67
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 69.64
  • ALOGS: -3.78
  • ROTB: 8

Drug dosage:

DoseUnitRoute
0.40 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,STK33,SYK,TEK,TGFBR1,TTK 31
kinase-selectivity-class AXL,GRK2,MAP2K6 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AB07 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35493 antipyretic

Related Drugs by ATC class:

M01AB Acetic acid derivatives and related substances 16 drugs
aceclofenacacemetacinalclofenacbufexamacdiclofenacdifenpiramideetodolacfentiazacindomethacinketorolaclonazolacoxametacin show all 16 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.54 acidic
pKa2 1.3 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07264 KEGG_DRUG
19847 RXNORM
C0054219 UMLSCUI
CHEBI:76119 CHEBI
CHEMBL2105456 ChEMBL_ID
DB13286 DRUGBANK_ID
C100233 MESH_SUPPLEMENTAL_RECORD_UI
19161 PUBCHEM_CID
2847 INN_ID
69365-73-7 SECONDARY_CAS_RN
ATD81G944M UNII
005444 NDDF
005445 NDDF

Pharmaceutical products:

None