temocapril Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
angiotensin-converting enzyme inhibitors 2586 111902-57-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • temocapril
  • temocapril hydrochloride
  • CS-622
  • temocapril HCl
  • Molecular weight: 476.61
  • Formula: C23H28N2O5S2
  • CLOGP: 2.10
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -5.14
  • ROTB: 11

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1.50 % Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1994 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C09AA14 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, PLAIN
ACE inhibitors, plain
MeSH PA D000806 Angiotensin-Converting Enzyme Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011480 Protease Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.12 acidic
pKa2 5.71 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Angiotensin-converting enzyme Enzyme INHIBITOR DRUG LABEL SCIENTIFIC LITERATURE
Angiotensin-converting enzyme Enzyme INHIBITOR IC50 8.44 SCIENTIFIC LITERATURE

External reference:

IDSource
D01119 KEGG_DRUG
18IZ008EU6 UNII
6712 INN_ID
110221-53-9 SECONDARY_CAS_RN
010988 NDDF
CHEMBL300841 ChEMBL_ID
C055603 MESH_SUPPLEMENTAL_RECORD_UI
DB08836 DRUGBANK_ID
CHEBI:135771 CHEBI
CHEMBL2104499 ChEMBL_ID
CHEMBL2110627 ChEMBL_ID
443874 PUBCHEM_CID
C069156 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None