temocapril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin-converting enzyme inhibitors | 2586 | 111902-57-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 1.50 % | Benet LZ, Broccatelli F, Oprea TI |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1994 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C09AA14 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, PLAIN ACE inhibitors, plain |
| MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.12 | acidic |
| pKa2 | 5.71 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Enzyme | INHIBITOR | DRUG LABEL | SCIENTIFIC LITERATURE | |||||
| Angiotensin-converting enzyme | Enzyme | INHIBITOR | IC50 | 8.44 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D01119 | KEGG_DRUG |
| C0753183 | UMLSCUI |
| CHEBI:32190 | CHEBI |
| CHEBI:9436 | CHEBI |
| CHEMBL2110627 | ChEMBL_ID |
| DB08836 | DRUGBANK_ID |
| C055603 | MESH_SUPPLEMENTAL_RECORD_UI |
| 11736 | IUPHAR_LIGAND_ID |
| C069156 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6712 | INN_ID |
| 110221-44-8 | SECONDARY_CAS_RN |
| 18IZ008EU6 | UNII |
| 443874 | PUBCHEM_CID |
| 010988 | NDDF |
| 010989 | NDDF |
| C0646101 | UMLSCUI |
| CHEMBL2104499 | ChEMBL_ID |
| CHEMBL300841 | ChEMBL_ID |
| 7673 | INN_ID |
| 110221-53-9 | SECONDARY_CAS_RN |
| 443151 | PUBCHEM_CID |
| 11737 | IUPHAR_LIGAND_ID |
| 2D6A12Q12R | UNII |
Pharmaceutical products:
None