Stem definition | Drug id | CAS RN |
---|---|---|
beta-adrenoreceptor antagonists | 2303 | 525-66-6 |
Dose | Unit | Route |
---|---|---|
0.16 | g | O |
0.16 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.25 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 35.25 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 26 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 3.10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 12 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.13 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 3.40 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 13, 1967 | FDA | BAXTER HLTHCARE CORP |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product administered to patient of inappropriate age | 1151.63 | 10.08 | 333 | 75639 | 2935 | 63410115 |
Completed suicide | 788.43 | 10.08 | 920 | 75052 | 144753 | 63268297 |
Toxicity to various agents | 409.66 | 10.08 | 909 | 75063 | 246341 | 63166709 |
Bradycardia | 397.97 | 10.08 | 464 | 75508 | 72763 | 63340287 |
Drug ineffective for unapproved indication | 376.55 | 10.08 | 318 | 75654 | 33745 | 63379305 |
Off label use | 351.99 | 10.08 | 1664 | 74308 | 672798 | 62740252 |
Cardiac arrest | 286.82 | 10.08 | 446 | 75526 | 92099 | 63320951 |
Infantile spitting up | 232.75 | 10.08 | 46 | 75926 | 44 | 63413006 |
Coma | 201.86 | 10.08 | 312 | 75660 | 64052 | 63348998 |
Overdose | 195.62 | 10.08 | 428 | 75544 | 114650 | 63298400 |
Product use in unapproved indication | 175.94 | 10.08 | 542 | 75430 | 178538 | 63234512 |
Intentional overdose | 175.71 | 10.08 | 317 | 75655 | 73835 | 63339215 |
Hand deformity | 171.58 | 10.08 | 4 | 75968 | 159453 | 63253597 |
Glossodynia | 170.67 | 10.08 | 11 | 75961 | 178865 | 63234185 |
Inappropriate schedule of product administration | 170.27 | 10.08 | 381 | 75591 | 103584 | 63309466 |
Systemic lupus erythematosus | 167.77 | 10.08 | 25 | 75947 | 208893 | 63204157 |
Hypotension | 165.48 | 10.08 | 705 | 75267 | 271899 | 63141151 |
Cardio-respiratory arrest | 165.17 | 10.08 | 274 | 75698 | 59685 | 63353365 |
Wound | 158.89 | 10.08 | 9 | 75963 | 163254 | 63249796 |
Ulcerated haemangioma | 148.97 | 10.08 | 26 | 75946 | 0 | 63413050 |
Drug interaction | 138.52 | 10.08 | 592 | 75380 | 228539 | 63184511 |
Product use issue | 137.38 | 10.08 | 575 | 75397 | 219945 | 63193105 |
Pericarditis | 132.00 | 10.08 | 6 | 75966 | 131573 | 63281477 |
Peripheral coldness | 123.05 | 10.08 | 108 | 75864 | 12057 | 63400993 |
Electrocardiogram QRS complex prolonged | 120.83 | 10.08 | 80 | 75892 | 5858 | 63407192 |
Joint swelling | 120.14 | 10.08 | 129 | 75843 | 327537 | 63085513 |
Respiratory arrest | 114.79 | 10.08 | 167 | 75805 | 32478 | 63380572 |
Swelling | 113.03 | 10.08 | 98 | 75874 | 275280 | 63137770 |
Sinus bradycardia | 106.56 | 10.08 | 108 | 75864 | 14443 | 63398607 |
Alopecia | 101.82 | 10.08 | 154 | 75818 | 337382 | 63075668 |
Electrocardiogram QT prolonged | 99.46 | 10.08 | 220 | 75752 | 59310 | 63353740 |
Cardiogenic shock | 97.91 | 10.08 | 114 | 75858 | 17818 | 63395232 |
Helicobacter infection | 97.27 | 10.08 | 3 | 75969 | 92782 | 63320268 |
Suicidal ideation | 96.85 | 10.08 | 224 | 75748 | 62197 | 63350853 |
Hypoglycaemia | 95.90 | 10.08 | 218 | 75754 | 59847 | 63353203 |
Lower respiratory tract infection | 95.02 | 10.08 | 21 | 75951 | 132286 | 63280764 |
Suicide attempt | 92.75 | 10.08 | 217 | 75755 | 60701 | 63352349 |
Seizure | 91.37 | 10.08 | 357 | 75615 | 132277 | 63280773 |
Pulseless electrical activity | 88.84 | 10.08 | 73 | 75899 | 7448 | 63405602 |
Rheumatoid arthritis | 88.53 | 10.08 | 104 | 75868 | 253715 | 63159335 |
Synovitis | 87.57 | 10.08 | 58 | 75914 | 186860 | 63226190 |
Neovascularisation | 83.05 | 10.08 | 36 | 75936 | 1109 | 63411941 |
Circulatory collapse | 82.67 | 10.08 | 116 | 75856 | 21822 | 63391228 |
Brain injury | 80.35 | 10.08 | 67 | 75905 | 6976 | 63406074 |
Arthropathy | 79.96 | 10.08 | 98 | 75874 | 234694 | 63178356 |
Poisoning deliberate | 79.85 | 10.08 | 82 | 75890 | 11136 | 63401914 |
Infection | 79.80 | 10.08 | 94 | 75878 | 229079 | 63183971 |
Arthralgia | 78.48 | 10.08 | 383 | 75589 | 569327 | 62843723 |
Paradoxical drug reaction | 77.45 | 10.08 | 53 | 75919 | 4099 | 63408951 |
Abdominal discomfort | 77.41 | 10.08 | 168 | 75804 | 320717 | 63092333 |
Extrapyramidal disorder | 73.44 | 10.08 | 85 | 75887 | 13199 | 63399851 |
Pain | 69.42 | 10.08 | 561 | 75411 | 740067 | 62672983 |
Thyrotoxic crisis | 68.34 | 10.08 | 29 | 75943 | 847 | 63412203 |
Discomfort | 68.09 | 10.08 | 60 | 75912 | 167314 | 63245736 |
Infusion related reaction | 67.45 | 10.08 | 119 | 75853 | 245402 | 63167648 |
Anuria | 67.20 | 10.08 | 79 | 75893 | 12472 | 63400578 |
Sleep terror | 66.70 | 10.08 | 41 | 75931 | 2639 | 63410411 |
Impaired healing | 64.70 | 10.08 | 21 | 75951 | 102521 | 63310529 |
Nightmare | 64.31 | 10.08 | 96 | 75876 | 19098 | 63393952 |
Somnolence | 63.96 | 10.08 | 399 | 75573 | 178286 | 63234764 |
Migraine | 63.85 | 10.08 | 269 | 75703 | 103077 | 63309973 |
Folliculitis | 62.34 | 10.08 | 6 | 75966 | 70311 | 63342739 |
Drug withdrawal syndrome | 61.51 | 10.08 | 114 | 75858 | 27080 | 63385970 |
Stomatitis | 61.06 | 10.08 | 46 | 75926 | 138679 | 63274371 |
Phaeochromocytoma | 60.70 | 10.08 | 23 | 75949 | 496 | 63412554 |
Blister | 55.92 | 10.08 | 44 | 75928 | 129770 | 63283280 |
Shock | 55.14 | 10.08 | 100 | 75872 | 23363 | 63389687 |
Peripheral swelling | 54.85 | 10.08 | 151 | 75821 | 265791 | 63147259 |
Hepatic enzyme increased | 54.71 | 10.08 | 99 | 75873 | 202229 | 63210821 |
Hypoglycaemic seizure | 54.65 | 10.08 | 21 | 75951 | 471 | 63412579 |
Therapeutic product effect decreased | 54.53 | 10.08 | 92 | 75880 | 193095 | 63219955 |
Tremor | 54.18 | 10.08 | 306 | 75666 | 131933 | 63281117 |
Respiratory depression | 53.88 | 10.08 | 74 | 75898 | 13641 | 63399409 |
Hyperthyroidism | 51.48 | 10.08 | 75 | 75897 | 14598 | 63398452 |
Retinal detachment | 50.60 | 10.08 | 48 | 75924 | 5921 | 63407129 |
Metabolic acidosis | 50.43 | 10.08 | 143 | 75829 | 44926 | 63368124 |
Nasopharyngitis | 49.76 | 10.08 | 148 | 75824 | 254109 | 63158941 |
Hepatic encephalopathy | 49.11 | 10.08 | 64 | 75908 | 11218 | 63401832 |
Sinusitis | 48.76 | 10.08 | 126 | 75846 | 226527 | 63186523 |
Fatigue | 48.16 | 10.08 | 761 | 75211 | 887267 | 62525783 |
Sleep disorder due to general medical condition, insomnia type | 47.51 | 10.08 | 4 | 75968 | 52213 | 63360837 |
Maternal exposure during pregnancy | 46.83 | 10.08 | 123 | 75849 | 219939 | 63193111 |
Disease progression | 46.40 | 10.08 | 47 | 75925 | 122711 | 63290339 |
Irritability | 46.16 | 10.08 | 111 | 75861 | 31583 | 63381467 |
Rash | 46.15 | 10.08 | 439 | 75533 | 560432 | 62852618 |
Contraindicated product administered | 45.29 | 10.08 | 123 | 75849 | 217525 | 63195525 |
Suspected suicide | 44.93 | 10.08 | 47 | 75925 | 6521 | 63406529 |
Mobility decreased | 43.98 | 10.08 | 48 | 75924 | 121111 | 63291939 |
Brain death | 42.17 | 10.08 | 34 | 75938 | 3376 | 63409674 |
Disturbance in attention | 41.59 | 10.08 | 120 | 75852 | 38069 | 63374981 |
Somatic delusion | 40.94 | 10.08 | 18 | 75954 | 574 | 63412476 |
Galactorrhoea | 40.25 | 10.08 | 36 | 75936 | 4119 | 63408931 |
Agitation | 39.62 | 10.08 | 159 | 75813 | 59598 | 63353452 |
Depression | 39.14 | 10.08 | 383 | 75589 | 196109 | 63216941 |
Pyrexia | 38.77 | 10.08 | 368 | 75604 | 470110 | 62942940 |
Electrocardiogram QRS complex shortened | 38.17 | 10.08 | 16 | 75956 | 453 | 63412597 |
Depressed level of consciousness | 37.87 | 10.08 | 161 | 75811 | 61917 | 63351133 |
Panic attack | 37.81 | 10.08 | 83 | 75889 | 22248 | 63390802 |
Hyperhidrosis | 36.81 | 10.08 | 238 | 75734 | 107598 | 63305452 |
Pain in extremity | 36.74 | 10.08 | 239 | 75733 | 331247 | 63081803 |
Gastrointestinal disorder | 36.56 | 10.08 | 63 | 75909 | 131176 | 63281874 |
Loss of consciousness | 35.72 | 10.08 | 253 | 75719 | 117868 | 63295182 |
Akathisia | 35.41 | 10.08 | 49 | 75923 | 9097 | 63403953 |
Ill-defined disorder | 34.83 | 10.08 | 28 | 75944 | 81727 | 63331323 |
Knee arthroplasty | 34.37 | 10.08 | 11 | 75961 | 54195 | 63358855 |
Generalised tonic-clonic seizure | 34.36 | 10.08 | 94 | 75878 | 28922 | 63384128 |
Intentional product use issue | 34.18 | 10.08 | 63 | 75909 | 127829 | 63285221 |
Migraine with aura | 33.21 | 10.08 | 27 | 75945 | 2713 | 63410337 |
Insulin autoimmune syndrome | 33.08 | 10.08 | 10 | 75962 | 104 | 63412946 |
Sleep disorder | 32.90 | 10.08 | 188 | 75784 | 81378 | 63331672 |
Swollen tongue | 32.86 | 10.08 | 104 | 75868 | 34696 | 63378354 |
Pneumonia | 32.81 | 10.08 | 369 | 75603 | 456398 | 62956652 |
Hip arthroplasty | 31.42 | 10.08 | 9 | 75963 | 47637 | 63365413 |
Atrioventricular block first degree | 31.26 | 10.08 | 41 | 75931 | 7232 | 63405818 |
Vascular malformation | 31.05 | 10.08 | 13 | 75959 | 367 | 63412683 |
Irritable bowel syndrome | 30.63 | 10.08 | 32 | 75940 | 82380 | 63330670 |
Hallucination, auditory | 30.56 | 10.08 | 55 | 75917 | 12769 | 63400281 |
Insomnia | 30.32 | 10.08 | 392 | 75580 | 214860 | 63198190 |
Hallucination | 30.27 | 10.08 | 138 | 75834 | 54679 | 63358371 |
Coma scale abnormal | 30.22 | 10.08 | 34 | 75938 | 5119 | 63407931 |
Serotonin syndrome | 30.15 | 10.08 | 89 | 75883 | 28593 | 63384457 |
Neuropathy peripheral | 29.48 | 10.08 | 57 | 75915 | 113610 | 63299440 |
Foetal alcohol syndrome | 29.28 | 10.08 | 7 | 75965 | 26 | 63413024 |
Atrioventricular block | 28.16 | 10.08 | 40 | 75932 | 7607 | 63405443 |
Negative symptoms in schizophrenia | 28.10 | 10.08 | 9 | 75963 | 115 | 63412935 |
Myocardial oedema | 27.00 | 10.08 | 10 | 75962 | 202 | 63412848 |
Paranasal cyst | 26.94 | 10.08 | 12 | 75960 | 395 | 63412655 |
Distributive shock | 26.62 | 10.08 | 18 | 75954 | 1365 | 63411685 |
Musculoskeletal stiffness | 26.54 | 10.08 | 122 | 75850 | 184496 | 63228554 |
Ear infection | 26.39 | 10.08 | 103 | 75869 | 38110 | 63374940 |
Teething | 26.34 | 10.08 | 6 | 75966 | 17 | 63413033 |
Vision blurred | 26.12 | 10.08 | 194 | 75778 | 91730 | 63321320 |
Withdrawal syndrome | 25.93 | 10.08 | 67 | 75905 | 19930 | 63393120 |
Type 2 diabetes mellitus | 25.83 | 10.08 | 23 | 75949 | 63845 | 63349205 |
Oesophageal obstruction | 25.75 | 10.08 | 13 | 75959 | 569 | 63412481 |
Anxiety | 25.70 | 10.08 | 384 | 75588 | 217157 | 63195893 |
Mydriasis | 25.64 | 10.08 | 49 | 75923 | 11907 | 63401143 |
Death | 25.48 | 10.08 | 306 | 75666 | 374075 | 63038975 |
Herpes zoster | 25.41 | 10.08 | 37 | 75935 | 82425 | 63330625 |
Hyperthermia | 25.40 | 10.08 | 42 | 75930 | 9114 | 63403936 |
Hyperammonaemic encephalopathy | 25.40 | 10.08 | 22 | 75950 | 2412 | 63410638 |
Hepatocellular carcinoma | 25.29 | 10.08 | 21 | 75951 | 2173 | 63410877 |
Cerebral disorder | 25.08 | 10.08 | 29 | 75943 | 4497 | 63408553 |
Eosinophilic myocarditis | 24.97 | 10.08 | 13 | 75959 | 607 | 63412443 |
Accessory cardiac pathway | 24.71 | 10.08 | 5 | 75967 | 6 | 63413044 |
Derailment | 24.58 | 10.08 | 7 | 75965 | 58 | 63412992 |
General physical health deterioration | 24.49 | 10.08 | 141 | 75831 | 201261 | 63211789 |
Productive cough | 24.10 | 10.08 | 24 | 75948 | 63184 | 63349866 |
Haemoglobin decreased | 24.10 | 10.08 | 91 | 75881 | 145394 | 63267656 |
Mental disorder | 24.05 | 10.08 | 77 | 75895 | 25842 | 63387208 |
Infusion site streaking | 24.03 | 10.08 | 12 | 75960 | 513 | 63412537 |
Blood prolactin increased | 23.84 | 10.08 | 25 | 75947 | 3478 | 63409572 |
Febrile neutropenia | 23.83 | 10.08 | 68 | 75904 | 118381 | 63294669 |
Hypothermia | 23.59 | 10.08 | 51 | 75921 | 13530 | 63399520 |
Thyroxine free decreased | 23.52 | 10.08 | 13 | 75959 | 685 | 63412365 |
Palpitations | 23.51 | 10.08 | 222 | 75750 | 112548 | 63300502 |
Distractibility | 22.87 | 10.08 | 11 | 75961 | 433 | 63412617 |
Granuloma skin | 22.47 | 10.08 | 38 | 75934 | 8399 | 63404651 |
Varices oesophageal | 22.38 | 10.08 | 23 | 75949 | 3125 | 63409925 |
Pleural effusion | 22.26 | 10.08 | 49 | 75923 | 93161 | 63319889 |
Cyanosis | 22.22 | 10.08 | 57 | 75915 | 16878 | 63396172 |
Antipsychotic drug level decreased | 22.07 | 10.08 | 10 | 75962 | 343 | 63412707 |
Oedema | 21.96 | 10.08 | 53 | 75919 | 97569 | 63315481 |
Interstitial lung disease | 21.94 | 10.08 | 25 | 75947 | 61883 | 63351167 |
Torsade de pointes | 21.90 | 10.08 | 49 | 75923 | 13302 | 63399748 |
Hyperreflexia | 21.79 | 10.08 | 31 | 75941 | 5903 | 63407147 |
Hyperprolactinaemia | 21.63 | 10.08 | 25 | 75947 | 3875 | 63409175 |
Narrow anterior chamber angle | 21.36 | 10.08 | 6 | 75966 | 47 | 63413003 |
Poor quality sleep | 21.08 | 10.08 | 62 | 75910 | 19873 | 63393177 |
Haematemesis | 21.02 | 10.08 | 82 | 75890 | 30330 | 63382720 |
Lip swelling | 20.86 | 10.08 | 83 | 75889 | 30980 | 63382070 |
Dizziness | 20.82 | 10.08 | 667 | 75305 | 429258 | 62983792 |
Dystonia | 20.77 | 10.08 | 49 | 75923 | 13770 | 63399280 |
Urine amphetamine positive | 20.63 | 10.08 | 6 | 75966 | 54 | 63412996 |
Chemical burn | 20.30 | 10.08 | 10 | 75962 | 415 | 63412635 |
Middle insomnia | 20.29 | 10.08 | 46 | 75926 | 12597 | 63400453 |
Adrenal suppression | 20.15 | 10.08 | 13 | 75959 | 911 | 63412139 |
Retroperitoneal fibrosis | 20.10 | 10.08 | 9 | 75963 | 300 | 63412750 |
Porphyrins urine increased | 20.06 | 10.08 | 5 | 75967 | 23 | 63413027 |
Acquired porphyria | 20.06 | 10.08 | 5 | 75967 | 23 | 63413027 |
Pituitary apoplexy | 19.65 | 10.08 | 7 | 75965 | 126 | 63412924 |
Blood cholesterol increased | 19.64 | 10.08 | 53 | 75919 | 93979 | 63319071 |
Hallucination, visual | 19.45 | 10.08 | 59 | 75913 | 19239 | 63393811 |
Therapeutic product ineffective for unapproved indication | 19.37 | 10.08 | 8 | 75964 | 218 | 63412832 |
Cerebral vasoconstriction | 19.24 | 10.08 | 14 | 75958 | 1194 | 63411856 |
Depressed mood | 19.16 | 10.08 | 97 | 75875 | 40094 | 63372956 |
Ventricular tachycardia | 19.13 | 10.08 | 60 | 75912 | 19919 | 63393131 |
Feeling abnormal | 19.12 | 10.08 | 266 | 75706 | 148126 | 63264924 |
Cholestasis of pregnancy | 19.06 | 10.08 | 14 | 75958 | 1211 | 63411839 |
Drug titration error | 18.99 | 10.08 | 12 | 75960 | 811 | 63412239 |
Hypermobility syndrome | 18.99 | 10.08 | 12 | 75960 | 811 | 63412239 |
Oesophageal varices haemorrhage | 18.97 | 10.08 | 14 | 75958 | 1220 | 63411830 |
Porphyrins stool increased | 18.95 | 10.08 | 5 | 75967 | 30 | 63413020 |
Neutropenia | 18.94 | 10.08 | 127 | 75845 | 174878 | 63238172 |
Product administration interrupted | 18.86 | 10.08 | 26 | 75946 | 4810 | 63408240 |
Hypersensitivity | 18.85 | 10.08 | 242 | 75730 | 292443 | 63120607 |
Ventricular arrhythmia | 18.70 | 10.08 | 23 | 75949 | 3805 | 63409245 |
Myocardial depression | 18.69 | 10.08 | 10 | 75962 | 494 | 63412556 |
Panic reaction | 18.67 | 10.08 | 24 | 75948 | 4150 | 63408900 |
Blood parathyroid hormone decreased | 18.43 | 10.08 | 38 | 75934 | 9753 | 63403297 |
Tardive dyskinesia | 18.42 | 10.08 | 35 | 75937 | 8467 | 63404583 |
Joint range of motion decreased | 18.18 | 10.08 | 8 | 75964 | 32420 | 63380630 |
Lethargy | 18.12 | 10.08 | 122 | 75850 | 55885 | 63357165 |
Apraxia | 18.08 | 10.08 | 16 | 75956 | 1805 | 63411245 |
Acute lung injury | 18.03 | 10.08 | 15 | 75957 | 1556 | 63411494 |
Muscle contractions involuntary | 17.96 | 10.08 | 18 | 75954 | 2374 | 63410676 |
Poisoning | 17.86 | 10.08 | 46 | 75926 | 13654 | 63399396 |
Perseveration | 17.86 | 10.08 | 8 | 75964 | 267 | 63412783 |
Fibromyalgia | 17.82 | 10.08 | 44 | 75928 | 80376 | 63332674 |
Teratogenicity | 17.80 | 10.08 | 8 | 75964 | 269 | 63412781 |
Dyspnoea | 17.64 | 10.08 | 631 | 75341 | 660682 | 62752368 |
Laryngeal dyspnoea | 17.58 | 10.08 | 7 | 75965 | 173 | 63412877 |
Therapeutic product effective for unapproved indication | 17.49 | 10.08 | 6 | 75966 | 96 | 63412954 |
Oedema peripheral | 17.42 | 10.08 | 144 | 75828 | 189367 | 63223683 |
Thyrotoxic cardiomyopathy | 17.19 | 10.08 | 3 | 75969 | 0 | 63413050 |
Bradycardia foetal | 17.15 | 10.08 | 9 | 75963 | 427 | 63412623 |
Grip strength decreased | 17.12 | 10.08 | 3 | 75969 | 22284 | 63390766 |
Wheezing | 17.02 | 10.08 | 58 | 75914 | 95537 | 63317513 |
Hyponatraemic seizure | 17.02 | 10.08 | 9 | 75963 | 434 | 63412616 |
Vasoplegia syndrome | 17.01 | 10.08 | 15 | 75957 | 1684 | 63411366 |
Chromaturia | 16.74 | 10.08 | 51 | 75921 | 16666 | 63396384 |
Panniculitis | 16.71 | 10.08 | 40 | 75932 | 11345 | 63401705 |
Dissociation | 16.68 | 10.08 | 19 | 75953 | 2900 | 63410150 |
Haemodynamic instability | 16.52 | 10.08 | 35 | 75937 | 9155 | 63403895 |
Jaundice | 16.41 | 10.08 | 74 | 75898 | 29177 | 63383873 |
Bezoar | 16.34 | 10.08 | 14 | 75958 | 1512 | 63411538 |
Mastoiditis | 16.29 | 10.08 | 12 | 75960 | 1043 | 63412007 |
Postural orthostatic tachycardia syndrome | 16.25 | 10.08 | 13 | 75959 | 1276 | 63411774 |
Psychotic symptom | 16.07 | 10.08 | 14 | 75958 | 1547 | 63411503 |
Alcohol interaction | 16.05 | 10.08 | 17 | 75955 | 2392 | 63410658 |
Aphasia | 15.98 | 10.08 | 80 | 75892 | 32920 | 63380130 |
Accelerated idioventricular rhythm | 15.89 | 10.08 | 5 | 75967 | 60 | 63412990 |
Mood swings | 15.84 | 10.08 | 53 | 75919 | 18195 | 63394855 |
Gynaecomastia | 15.81 | 10.08 | 7 | 75965 | 227 | 63412823 |
Heart rate decreased | 15.81 | 10.08 | 101 | 75871 | 45459 | 63367591 |
Exposure via transplant | 15.78 | 10.08 | 4 | 75968 | 20 | 63413030 |
Back pain | 15.70 | 10.08 | 222 | 75750 | 263923 | 63149127 |
Therapy non-responder | 15.69 | 10.08 | 43 | 75929 | 75858 | 63337192 |
Breath sounds abnormal | 15.52 | 10.08 | 38 | 75934 | 10935 | 63402115 |
Therapeutic product effect incomplete | 15.49 | 10.08 | 87 | 75885 | 124969 | 63288081 |
Wrong patient received product | 15.47 | 10.08 | 16 | 75956 | 2191 | 63410859 |
Headache | 15.46 | 10.08 | 915 | 75057 | 632326 | 62780724 |
Prescribed overdose | 15.44 | 10.08 | 11 | 75961 | 34142 | 63378908 |
Pulse absent | 15.38 | 10.08 | 25 | 75947 | 5349 | 63407701 |
Skin necrosis | 15.34 | 10.08 | 44 | 75928 | 13906 | 63399144 |
Paraganglion neoplasm | 15.31 | 10.08 | 4 | 75968 | 23 | 63413027 |
Cerebellar syndrome | 15.28 | 10.08 | 20 | 75952 | 3519 | 63409531 |
Bradypnoea | 15.24 | 10.08 | 20 | 75952 | 3530 | 63409520 |
Contusion | 15.20 | 10.08 | 111 | 75861 | 149933 | 63263117 |
Defect conduction intraventricular | 15.16 | 10.08 | 6 | 75966 | 146 | 63412904 |
Sprue-like enteropathy | 15.09 | 10.08 | 10 | 75962 | 733 | 63412317 |
Agoraphobia | 15.09 | 10.08 | 8 | 75964 | 388 | 63412662 |
Breath holding | 15.08 | 10.08 | 6 | 75966 | 148 | 63412902 |
Gastrointestinal motility disorder | 14.90 | 10.08 | 24 | 75948 | 5095 | 63407955 |
Feeling guilty | 14.73 | 10.08 | 9 | 75963 | 573 | 63412477 |
Self-injurious ideation | 14.67 | 10.08 | 17 | 75955 | 2642 | 63410408 |
Psoriatic arthropathy | 14.67 | 10.08 | 58 | 75914 | 91462 | 63321588 |
Lung disorder | 14.64 | 10.08 | 33 | 75939 | 62228 | 63350822 |
Metastases to liver | 14.63 | 10.08 | 5 | 75967 | 23634 | 63389416 |
Malignant neoplasm progression | 14.50 | 10.08 | 50 | 75922 | 82071 | 63330979 |
Musculoskeletal pain | 14.46 | 10.08 | 59 | 75913 | 92218 | 63320832 |
Tic | 14.39 | 10.08 | 13 | 75959 | 1507 | 63411543 |
Unresponsive to stimuli | 14.33 | 10.08 | 79 | 75893 | 33737 | 63379313 |
Liver injury | 14.29 | 10.08 | 32 | 75940 | 60488 | 63352562 |
Tumour rupture | 14.28 | 10.08 | 6 | 75966 | 171 | 63412879 |
Nervousness | 14.23 | 10.08 | 74 | 75898 | 30905 | 63382145 |
Visual field defect | 14.20 | 10.08 | 27 | 75945 | 6534 | 63406516 |
Medication overuse headache | 14.07 | 10.08 | 10 | 75962 | 822 | 63412228 |
Congenital pharyngeal anomaly | 13.90 | 10.08 | 3 | 75969 | 6 | 63413044 |
Essential tremor | 13.78 | 10.08 | 11 | 75961 | 1077 | 63411973 |
Food craving | 13.78 | 10.08 | 13 | 75959 | 1593 | 63411457 |
Behaviour disorder | 13.69 | 10.08 | 18 | 75954 | 3181 | 63409869 |
Extra dose administered | 13.58 | 10.08 | 26 | 75946 | 6324 | 63406726 |
Salivary hypersecretion | 13.56 | 10.08 | 29 | 75943 | 7637 | 63405413 |
Vertigo | 13.54 | 10.08 | 120 | 75852 | 59767 | 63353283 |
Thyroxine free increased | 13.52 | 10.08 | 10 | 75962 | 874 | 63412176 |
Somnambulism | 13.50 | 10.08 | 24 | 75948 | 5519 | 63407531 |
Monoclonal gammopathy | 13.46 | 10.08 | 9 | 75963 | 670 | 63412380 |
Exposure via ingestion | 13.44 | 10.08 | 17 | 75955 | 2892 | 63410158 |
Hepatic steatosis | 13.41 | 10.08 | 69 | 75903 | 28700 | 63384350 |
Abnormal dreams | 13.39 | 10.08 | 35 | 75937 | 10481 | 63402569 |
Yellow skin | 13.30 | 10.08 | 15 | 75957 | 2265 | 63410785 |
Bundle branch block | 13.29 | 10.08 | 10 | 75962 | 897 | 63412153 |
Swelling face | 13.24 | 10.08 | 125 | 75847 | 63350 | 63349700 |
Dermatitis diaper | 13.23 | 10.08 | 6 | 75966 | 206 | 63412844 |
Pre-existing condition improved | 13.23 | 10.08 | 30 | 75942 | 8214 | 63404836 |
Intentional self-injury | 12.96 | 10.08 | 63 | 75909 | 25624 | 63387426 |
Hypoperfusion | 12.82 | 10.08 | 12 | 75960 | 1455 | 63411595 |
Altered state of consciousness | 12.81 | 10.08 | 62 | 75910 | 25168 | 63387882 |
Phonophobia | 12.80 | 10.08 | 7 | 75965 | 361 | 63412689 |
Rheumatoid factor positive | 12.59 | 10.08 | 55 | 75917 | 84351 | 63328699 |
Foot deformity | 12.55 | 10.08 | 9 | 75963 | 27844 | 63385206 |
Osteoarthritis | 12.54 | 10.08 | 65 | 75907 | 95278 | 63317772 |
Ventricular failure | 12.52 | 10.08 | 7 | 75965 | 377 | 63412673 |
Wound infection | 12.45 | 10.08 | 5 | 75967 | 21405 | 63391645 |
Alveolar bone resorption | 12.42 | 10.08 | 4 | 75968 | 52 | 63412998 |
Basilar migraine | 12.42 | 10.08 | 4 | 75968 | 52 | 63412998 |
Lung neoplasm malignant | 12.41 | 10.08 | 4 | 75968 | 19629 | 63393421 |
Aspiration of gastric residual | 12.37 | 10.08 | 3 | 75969 | 12 | 63413038 |
Migraine without aura | 12.37 | 10.08 | 7 | 75965 | 386 | 63412664 |
Stress ulcer | 12.35 | 10.08 | 4 | 75968 | 53 | 63412997 |
Treatment failure | 12.28 | 10.08 | 166 | 75806 | 198877 | 63214173 |
Agranulocytosis | 12.22 | 10.08 | 61 | 75911 | 25073 | 63387977 |
Disorientation | 12.20 | 10.08 | 85 | 75887 | 39367 | 63373683 |
Heart rate variability increased | 12.15 | 10.08 | 4 | 75968 | 56 | 63412994 |
Tonic convulsion | 12.09 | 10.08 | 11 | 75961 | 1286 | 63411764 |
Bursitis | 12.03 | 10.08 | 16 | 75956 | 37025 | 63376025 |
Sciatica | 12.01 | 10.08 | 14 | 75958 | 34310 | 63378740 |
Urinary tract infection | 11.94 | 10.08 | 234 | 75738 | 264450 | 63148600 |
Primary adrenal insufficiency | 11.88 | 10.08 | 5 | 75967 | 143 | 63412907 |
Product complaint | 11.83 | 10.08 | 38 | 75934 | 12771 | 63400279 |
Dyskinesia | 11.76 | 10.08 | 72 | 75900 | 31930 | 63381120 |
Diabetic ketosis | 11.73 | 10.08 | 6 | 75966 | 270 | 63412780 |
Tri-iodothyronine decreased | 11.69 | 10.08 | 5 | 75967 | 149 | 63412901 |
Cough | 11.68 | 10.08 | 264 | 75708 | 292479 | 63120571 |
Drug level increased | 11.64 | 10.08 | 56 | 75916 | 22680 | 63390370 |
Weight increased | 11.63 | 10.08 | 231 | 75741 | 260561 | 63152489 |
Sinus rhythm | 11.58 | 10.08 | 9 | 75963 | 847 | 63412203 |
Multiple lentigines syndrome | 11.57 | 10.08 | 5 | 75967 | 153 | 63412897 |
Anger | 11.55 | 10.08 | 37 | 75935 | 12419 | 63400631 |
Suicidal behaviour | 11.53 | 10.08 | 15 | 75957 | 2624 | 63410426 |
Tearfulness | 11.50 | 10.08 | 19 | 75953 | 4120 | 63408930 |
Thyroid cancer metastatic | 11.42 | 10.08 | 5 | 75967 | 158 | 63412892 |
Haemorrhagic tumour necrosis | 11.37 | 10.08 | 3 | 75969 | 18 | 63413032 |
Broad ligament tear | 11.37 | 10.08 | 3 | 75969 | 18 | 63413032 |
Bundle branch block right | 11.36 | 10.08 | 21 | 75951 | 4977 | 63408073 |
Porphyria non-acute | 11.31 | 10.08 | 6 | 75966 | 291 | 63412759 |
Blood pressure systolic increased | 11.24 | 10.08 | 25 | 75947 | 47372 | 63365678 |
Oculogyric crisis | 11.21 | 10.08 | 12 | 75960 | 1709 | 63411341 |
Cognitive disorder | 11.19 | 10.08 | 109 | 75863 | 55706 | 63357344 |
Abnormal faeces | 11.19 | 10.08 | 22 | 75950 | 5458 | 63407592 |
Septic arthritis staphylococcal | 11.17 | 10.08 | 7 | 75965 | 466 | 63412584 |
Conjunctival hyperaemia | 11.15 | 10.08 | 14 | 75958 | 2365 | 63410685 |
Atrophy | 11.15 | 10.08 | 12 | 75960 | 1720 | 63411330 |
Dyspnoea exertional | 11.14 | 10.08 | 36 | 75936 | 60266 | 63352784 |
Urine odour abnormal | 11.10 | 10.08 | 24 | 75948 | 6365 | 63406685 |
Sudden infant death syndrome | 11.09 | 10.08 | 6 | 75966 | 303 | 63412747 |
Nodal rhythm | 11.08 | 10.08 | 12 | 75960 | 1731 | 63411319 |
Inappropriate affect | 11.06 | 10.08 | 9 | 75963 | 905 | 63412145 |
Abdominal pain upper | 11.06 | 10.08 | 177 | 75795 | 206267 | 63206783 |
Atrioventricular septal defect | 10.96 | 10.08 | 6 | 75966 | 310 | 63412740 |
Palmar erythema | 10.95 | 10.08 | 12 | 75960 | 1755 | 63411295 |
Illness | 10.94 | 10.08 | 98 | 75874 | 48961 | 63364089 |
Thalamic infarction | 10.92 | 10.08 | 7 | 75965 | 485 | 63412565 |
Psychotic disorder | 10.85 | 10.08 | 60 | 75912 | 25652 | 63387398 |
Hand-foot-and-mouth disease | 10.83 | 10.08 | 5 | 75967 | 179 | 63412871 |
Memory impairment | 10.76 | 10.08 | 180 | 75792 | 104078 | 63308972 |
Bronchiectasis | 10.73 | 10.08 | 3 | 75969 | 16139 | 63396911 |
Aggression | 10.70 | 10.08 | 56 | 75916 | 23442 | 63389608 |
Respiratory syncytial virus infection | 10.67 | 10.08 | 25 | 75947 | 6993 | 63406057 |
Hyponatraemic coma | 10.63 | 10.08 | 3 | 75969 | 24 | 63413026 |
Chronotropic incompetence | 10.57 | 10.08 | 4 | 75968 | 86 | 63412964 |
Muscle rigidity | 10.52 | 10.08 | 34 | 75938 | 11466 | 63401584 |
Blood lactic acid increased | 10.51 | 10.08 | 25 | 75947 | 7061 | 63405989 |
Restless legs syndrome | 10.49 | 10.08 | 47 | 75925 | 18484 | 63394566 |
Oromandibular dystonia | 10.48 | 10.08 | 7 | 75965 | 520 | 63412530 |
Obsessive-compulsive disorder | 10.43 | 10.08 | 18 | 75954 | 4042 | 63409008 |
Choanal atresia | 10.41 | 10.08 | 3 | 75969 | 26 | 63413024 |
Tongue pruritus | 10.35 | 10.08 | 7 | 75965 | 531 | 63412519 |
Pruritus | 10.27 | 10.08 | 342 | 75630 | 361111 | 63051939 |
Drug dependence | 10.24 | 10.08 | 57 | 75915 | 24426 | 63388624 |
Actinic keratosis | 10.15 | 10.08 | 14 | 75958 | 2590 | 63410460 |
Poor feeding infant | 10.08 | 10.08 | 6 | 75966 | 364 | 63412686 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product administered to patient of inappropriate age | 525.90 | 11.06 | 182 | 40285 | 3109 | 34913355 |
Completed suicide | 299.70 | 11.06 | 461 | 40006 | 97707 | 34818757 |
Bradycardia | 264.31 | 11.06 | 378 | 40089 | 75040 | 34841424 |
Toxicity to various agents | 177.70 | 11.06 | 572 | 39895 | 199790 | 34716674 |
Hepatic encephalopathy | 176.61 | 11.06 | 142 | 40325 | 14543 | 34901921 |
Product use issue | 172.13 | 11.06 | 282 | 40185 | 62934 | 34853530 |
Product use in unapproved indication | 135.96 | 11.06 | 369 | 40098 | 117130 | 34799334 |
Intentional overdose | 108.38 | 11.06 | 187 | 40280 | 43487 | 34872977 |
Nightmare | 105.06 | 11.06 | 105 | 40362 | 14286 | 34902178 |
Cardiac arrest | 92.74 | 11.06 | 283 | 40184 | 95876 | 34820588 |
Hepatocellular carcinoma | 86.86 | 11.06 | 71 | 40396 | 7438 | 34909026 |
Sedation | 86.55 | 11.06 | 114 | 40353 | 20892 | 34895572 |
Varices oesophageal | 83.92 | 11.06 | 53 | 40414 | 3702 | 34912762 |
Oesophageal varices haemorrhage | 82.03 | 11.06 | 49 | 40418 | 3097 | 34913367 |
Off label use | 80.69 | 11.06 | 789 | 39678 | 418735 | 34497729 |
Parasomnia | 78.95 | 11.06 | 26 | 40441 | 378 | 34916086 |
Hyperthyroidism | 75.11 | 11.06 | 76 | 40391 | 10490 | 34905974 |
Febrile neutropenia | 70.76 | 11.06 | 35 | 40432 | 136814 | 34779650 |
Pneumonia | 70.62 | 11.06 | 202 | 40265 | 362425 | 34554039 |
Thyrotoxic periodic paralysis | 70.51 | 11.06 | 19 | 40448 | 130 | 34916334 |
Ascites | 67.02 | 11.06 | 159 | 40308 | 46412 | 34870052 |
Akathisia | 64.46 | 11.06 | 62 | 40405 | 8047 | 34908417 |
Myokymia | 64.31 | 11.06 | 16 | 40451 | 76 | 34916388 |
Hyperhidrosis | 61.36 | 11.06 | 210 | 40257 | 75482 | 34840982 |
Infantile spitting up | 60.83 | 11.06 | 14 | 40453 | 44 | 34916420 |
Poisoning deliberate | 60.53 | 11.06 | 59 | 40408 | 7785 | 34908679 |
Product used for unknown indication | 59.65 | 11.06 | 27 | 40440 | 956 | 34915508 |
Reversible airways obstruction | 59.09 | 11.06 | 22 | 40445 | 467 | 34915997 |
Encapsulating peritoneal sclerosis | 58.61 | 11.06 | 23 | 40444 | 566 | 34915898 |
Drug interaction | 53.46 | 11.06 | 445 | 40022 | 225501 | 34690963 |
Overdose | 51.95 | 11.06 | 226 | 40241 | 90833 | 34825631 |
Nephrolithiasis | 51.94 | 11.06 | 111 | 40356 | 30222 | 34886242 |
Hepatic cirrhosis | 50.82 | 11.06 | 80 | 40387 | 17234 | 34899230 |
Suicidal ideation | 50.81 | 11.06 | 131 | 40336 | 40257 | 34876207 |
Cerebral artery thrombosis | 49.16 | 11.06 | 22 | 40445 | 758 | 34915706 |
Areflexia | 49.02 | 11.06 | 35 | 40432 | 2996 | 34913468 |
Brain scan abnormal | 46.62 | 11.06 | 22 | 40445 | 858 | 34915606 |
Hepatorenal syndrome | 45.94 | 11.06 | 32 | 40435 | 2634 | 34913830 |
Cardiogenic shock | 45.10 | 11.06 | 97 | 40370 | 26521 | 34889943 |
Somnolence | 44.28 | 11.06 | 249 | 40218 | 110867 | 34805597 |
Peripheral coldness | 42.38 | 11.06 | 47 | 40420 | 7204 | 34909260 |
Hallucination, auditory | 42.02 | 11.06 | 60 | 40407 | 11857 | 34904607 |
Drug ineffective for unapproved indication | 40.85 | 11.06 | 87 | 40380 | 23628 | 34892836 |
Granulomatous rosacea | 38.54 | 11.06 | 12 | 40455 | 144 | 34916320 |
Cardio-respiratory arrest | 38.51 | 11.06 | 146 | 40321 | 55127 | 34861337 |
Sinus bradycardia | 38.18 | 11.06 | 60 | 40407 | 12903 | 34903561 |
Sleep disorder | 37.02 | 11.06 | 100 | 40367 | 31588 | 34884876 |
Foetal disorder | 35.79 | 11.06 | 18 | 40449 | 808 | 34915656 |
Neutropenia neonatal | 35.28 | 11.06 | 17 | 40450 | 695 | 34915769 |
Lethargy | 34.98 | 11.06 | 116 | 40351 | 41006 | 34875458 |
Tremor | 33.49 | 11.06 | 186 | 40281 | 82401 | 34834063 |
Disease progression | 33.16 | 11.06 | 46 | 40421 | 108031 | 34808433 |
Respiratory arrest | 32.26 | 11.06 | 88 | 40379 | 27955 | 34888509 |
Encephalopathy | 32.18 | 11.06 | 102 | 40365 | 35217 | 34881247 |
Abnormal sleep-related event | 31.54 | 11.06 | 14 | 40453 | 473 | 34915991 |
Psychotic disorder | 31.46 | 11.06 | 80 | 40387 | 24372 | 34892092 |
Neutrophil count decreased | 31.41 | 11.06 | 10 | 40457 | 51094 | 34865370 |
Platelet count decreased | 31.03 | 11.06 | 57 | 40410 | 119660 | 34796804 |
Malignant neoplasm progression | 30.65 | 11.06 | 34 | 40433 | 88012 | 34828452 |
Premature baby | 30.38 | 11.06 | 69 | 40398 | 19564 | 34896900 |
Low birth weight baby | 29.65 | 11.06 | 41 | 40426 | 7864 | 34908600 |
Pulseless electrical activity | 29.48 | 11.06 | 39 | 40428 | 7172 | 34909292 |
Granulocytopenia | 29.17 | 11.06 | 37 | 40430 | 6530 | 34909934 |
Photophobia | 28.99 | 11.06 | 38 | 40429 | 6926 | 34909538 |
Disturbance in attention | 28.44 | 11.06 | 80 | 40387 | 25865 | 34890599 |
Hepatitis C | 28.26 | 11.06 | 45 | 40422 | 9785 | 34906679 |
Suicidal behaviour | 28.23 | 11.06 | 19 | 40448 | 1478 | 34914986 |
Phaeochromocytoma malignant | 27.76 | 11.06 | 8 | 40459 | 72 | 34916392 |
Myocardial infarction | 27.67 | 11.06 | 62 | 40405 | 121023 | 34795441 |
Sepsis | 26.61 | 11.06 | 101 | 40366 | 166460 | 34750004 |
Dyspnoea | 26.45 | 11.06 | 294 | 40173 | 376488 | 34539976 |
White blood cell count decreased | 26.03 | 11.06 | 44 | 40423 | 95401 | 34821063 |
Depression | 26.03 | 11.06 | 197 | 40270 | 96901 | 34819563 |
Irritability | 25.96 | 11.06 | 75 | 40392 | 24615 | 34891849 |
Portal hypertensive gastropathy | 25.24 | 11.06 | 13 | 40454 | 614 | 34915850 |
Inappropriate schedule of product administration | 24.38 | 11.06 | 139 | 40328 | 62157 | 34854307 |
Insomnia | 24.14 | 11.06 | 204 | 40263 | 103703 | 34812761 |
Gastroenteritis eosinophilic | 24.05 | 11.06 | 9 | 40458 | 194 | 34916270 |
Thyrotoxic crisis | 23.92 | 11.06 | 11 | 40456 | 404 | 34916060 |
Drug withdrawal syndrome | 23.57 | 11.06 | 63 | 40404 | 19771 | 34896693 |
Tardive dyskinesia | 23.19 | 11.06 | 31 | 40436 | 5759 | 34910705 |
Rash | 23.09 | 11.06 | 157 | 40310 | 222595 | 34693869 |
Alcohol interaction | 22.64 | 11.06 | 22 | 40445 | 2891 | 34913573 |
Death | 22.21 | 11.06 | 326 | 40141 | 397723 | 34518741 |
Hypoglycaemia | 22.10 | 11.06 | 123 | 40344 | 54517 | 34861947 |
Interstitial lung disease | 21.86 | 11.06 | 26 | 40441 | 65256 | 34851208 |
Aggression | 21.65 | 11.06 | 96 | 40371 | 38868 | 34877596 |
Acute stress disorder | 21.52 | 11.06 | 8 | 40459 | 169 | 34916295 |
Drug dispensed to wrong patient | 21.48 | 11.06 | 11 | 40456 | 513 | 34915951 |
Hepatitis C RNA positive | 21.48 | 11.06 | 8 | 40459 | 170 | 34916294 |
Hepatopulmonary syndrome | 21.43 | 11.06 | 5 | 40462 | 17 | 34916447 |
Anxiety | 21.42 | 11.06 | 192 | 40275 | 99236 | 34817228 |
Pain | 21.34 | 11.06 | 144 | 40323 | 204531 | 34711933 |
Neuropathy peripheral | 21.25 | 11.06 | 40 | 40427 | 83223 | 34833241 |
Myocardial depression | 21.23 | 11.06 | 6 | 40461 | 50 | 34916414 |
Phonophobia | 21.05 | 11.06 | 8 | 40459 | 180 | 34916284 |
Hallucination | 20.87 | 11.06 | 116 | 40351 | 51382 | 34865082 |
Antipsychotic drug level increased | 20.79 | 11.06 | 24 | 40443 | 3841 | 34912623 |
Suicide attempt | 20.71 | 11.06 | 95 | 40372 | 39021 | 34877443 |
Prostate cancer | 20.68 | 11.06 | 10 | 40457 | 39639 | 34876825 |
Gastric varices | 20.58 | 11.06 | 11 | 40456 | 561 | 34915903 |
Alcoholism | 20.47 | 11.06 | 21 | 40446 | 2944 | 34913520 |
Cardiac failure congestive | 20.38 | 11.06 | 41 | 40426 | 83229 | 34833235 |
Genotype drug resistance test positive | 20.33 | 11.06 | 14 | 40453 | 1131 | 34915333 |
Brain injury | 20.31 | 11.06 | 30 | 40437 | 6112 | 34910352 |
Tinnitus | 20.09 | 11.06 | 60 | 40407 | 20058 | 34896406 |
Joint swelling | 19.90 | 11.06 | 24 | 40443 | 59866 | 34856598 |
Hypoaesthesia eye | 19.72 | 11.06 | 5 | 40462 | 26 | 34916438 |
Neutropenia | 19.66 | 11.06 | 104 | 40363 | 156674 | 34759790 |
Portal vein thrombosis | 19.51 | 11.06 | 23 | 40444 | 3765 | 34912699 |
Agitation | 19.23 | 11.06 | 123 | 40344 | 57276 | 34859188 |
Stomatitis | 18.93 | 11.06 | 13 | 40454 | 42501 | 34873963 |
Sexually inappropriate behaviour | 18.85 | 11.06 | 10 | 40457 | 502 | 34915962 |
Peripheral swelling | 18.47 | 11.06 | 38 | 40429 | 76503 | 34839961 |
Meningitis streptococcal | 18.33 | 11.06 | 5 | 40462 | 36 | 34916428 |
Chronic obstructive pulmonary disease | 18.02 | 11.06 | 18 | 40449 | 48900 | 34867564 |
Drug level below therapeutic | 17.95 | 11.06 | 27 | 40440 | 5588 | 34910876 |
Atrial fibrillation | 17.78 | 11.06 | 77 | 40390 | 122316 | 34794148 |
Hallucination, visual | 17.71 | 11.06 | 53 | 40414 | 17738 | 34898726 |
Hepatic failure | 17.64 | 11.06 | 83 | 40384 | 34448 | 34882016 |
Pain in extremity | 17.53 | 11.06 | 81 | 40386 | 126432 | 34790032 |
Electrocardiogram QRS complex shortened | 17.34 | 11.06 | 7 | 40460 | 186 | 34916278 |
Differential white blood cell count abnormal | 17.30 | 11.06 | 14 | 40453 | 1445 | 34915019 |
Phaeochromocytoma | 16.99 | 11.06 | 7 | 40460 | 196 | 34916268 |
Hypotension | 16.96 | 11.06 | 355 | 40112 | 221294 | 34695170 |
Mucosal inflammation | 16.94 | 11.06 | 12 | 40455 | 38610 | 34877854 |
Torsade de pointes | 16.74 | 11.06 | 30 | 40437 | 7179 | 34909285 |
Coma | 16.62 | 11.06 | 100 | 40367 | 45578 | 34870886 |
Renal impairment | 16.62 | 11.06 | 55 | 40412 | 94458 | 34822006 |
Arthralgia | 16.55 | 11.06 | 122 | 40345 | 169919 | 34746545 |
Pyrexia | 16.43 | 11.06 | 279 | 40188 | 332734 | 34583730 |
Atrioventricular block first degree | 16.30 | 11.06 | 27 | 40440 | 6065 | 34910399 |
Withdrawal syndrome | 16.28 | 11.06 | 41 | 40426 | 12414 | 34904050 |
Poor quality sleep | 16.23 | 11.06 | 32 | 40435 | 8224 | 34908240 |
Social avoidant behaviour | 16.19 | 11.06 | 19 | 40448 | 3095 | 34913369 |
Blunted affect | 16.06 | 11.06 | 8 | 40459 | 352 | 34916112 |
Crying | 15.72 | 11.06 | 26 | 40441 | 5836 | 34910628 |
Neuroleptic malignant syndrome | 15.61 | 11.06 | 51 | 40416 | 17883 | 34898581 |
Pseudoporphyria | 15.61 | 11.06 | 8 | 40459 | 374 | 34916090 |
Biliary anastomosis | 15.59 | 11.06 | 4 | 40463 | 22 | 34916442 |
Pneumonitis | 15.56 | 11.06 | 10 | 40457 | 33868 | 34882596 |
Binocular eye movement disorder | 15.55 | 11.06 | 5 | 40462 | 67 | 34916397 |
Drug-induced liver injury | 15.45 | 11.06 | 7 | 40460 | 28825 | 34887639 |
Suspected suicide | 15.42 | 11.06 | 23 | 40444 | 4725 | 34911739 |
Rheumatoid arthritis | 15.35 | 11.06 | 13 | 40454 | 38225 | 34878239 |
Peritoneal fibrosis | 15.21 | 11.06 | 3 | 40464 | 3 | 34916461 |
Renal hamartoma | 15.21 | 11.06 | 3 | 40464 | 3 | 34916461 |
Hepatic cancer | 14.99 | 11.06 | 31 | 40436 | 8244 | 34908220 |
Disorientation | 14.97 | 11.06 | 77 | 40390 | 33111 | 34883353 |
Sleep deficit | 14.96 | 11.06 | 9 | 40458 | 576 | 34915888 |
Intentional product misuse | 14.82 | 11.06 | 97 | 40370 | 45514 | 34870950 |
Genital swelling | 14.77 | 11.06 | 6 | 40461 | 162 | 34916302 |
Alcoholic liver disease | 14.64 | 11.06 | 9 | 40458 | 599 | 34915865 |
Lupus-like syndrome | 14.64 | 11.06 | 17 | 40450 | 2739 | 34913725 |
Patient dissatisfaction with treatment | 14.63 | 11.06 | 5 | 40462 | 82 | 34916382 |
Oesophageal variceal ligation | 14.63 | 11.06 | 5 | 40462 | 82 | 34916382 |
Vital functions abnormal | 14.60 | 11.06 | 7 | 40460 | 283 | 34916181 |
Restlessness | 14.32 | 11.06 | 63 | 40404 | 25419 | 34891045 |
Ventricular arrhythmia | 14.13 | 11.06 | 24 | 40443 | 5504 | 34910960 |
Negative thoughts | 14.08 | 11.06 | 9 | 40458 | 642 | 34915822 |
Micrographia | 14.00 | 11.06 | 3 | 40464 | 6 | 34916458 |
Laryngeal erythema | 14.00 | 11.06 | 3 | 40464 | 6 | 34916458 |
Seizure | 13.97 | 11.06 | 184 | 40283 | 104673 | 34811791 |
Ammonia increased | 13.96 | 11.06 | 21 | 40446 | 4348 | 34912116 |
Coma scale abnormal | 13.86 | 11.06 | 20 | 40447 | 3988 | 34912476 |
Withdrawal hypertension | 13.73 | 11.06 | 6 | 40461 | 195 | 34916269 |
Intentional self-injury | 13.68 | 11.06 | 41 | 40426 | 13730 | 34902734 |
Portal hypertension | 13.66 | 11.06 | 20 | 40447 | 4042 | 34912422 |
Blood creatinine increased | 13.64 | 11.06 | 60 | 40407 | 94916 | 34821548 |
Reflux gastritis | 13.60 | 11.06 | 7 | 40460 | 330 | 34916134 |
Wrong strength | 13.52 | 11.06 | 5 | 40462 | 104 | 34916360 |
Hypertrophic cardiomyopathy | 13.50 | 11.06 | 11 | 40456 | 1146 | 34915318 |
Blood pressure systolic decreased | 13.48 | 11.06 | 21 | 40446 | 4482 | 34911982 |
Drooling | 13.38 | 11.06 | 18 | 40449 | 3364 | 34913100 |
Gastric hypomotility | 13.35 | 11.06 | 5 | 40462 | 108 | 34916356 |
Pruritus | 13.27 | 11.06 | 103 | 40364 | 141878 | 34774586 |
Hypocalvaria | 13.08 | 11.06 | 4 | 40463 | 45 | 34916419 |
Psychomotor hyperactivity | 12.91 | 11.06 | 32 | 40435 | 9590 | 34906874 |
Plasma cell myeloma | 12.77 | 11.06 | 18 | 40449 | 42019 | 34874445 |
Acute kidney injury | 12.71 | 11.06 | 263 | 40204 | 304725 | 34611739 |
Maternal drugs affecting foetus | 12.58 | 11.06 | 19 | 40448 | 3946 | 34912518 |
Hypnagogic hallucination | 12.42 | 11.06 | 4 | 40463 | 54 | 34916410 |
Infusion related reaction | 12.24 | 11.06 | 27 | 40440 | 53030 | 34863434 |
Persecutory delusion | 12.20 | 11.06 | 15 | 40452 | 2565 | 34913899 |
Electrocardiogram QRS complex prolonged | 12.18 | 11.06 | 21 | 40446 | 4873 | 34911591 |
Growth hormone-producing pituitary tumour | 12.09 | 11.06 | 4 | 40463 | 59 | 34916405 |
Haemoglobin decreased | 12.06 | 11.06 | 86 | 40381 | 120686 | 34795778 |
Loss of bladder sensation | 12.03 | 11.06 | 4 | 40463 | 60 | 34916404 |
Thyroxine free increased | 12.02 | 11.06 | 6 | 40461 | 265 | 34916199 |
Delusion | 11.97 | 11.06 | 37 | 40430 | 12598 | 34903866 |
Action tremor | 11.97 | 11.06 | 4 | 40463 | 61 | 34916403 |
Hunger | 11.94 | 11.06 | 12 | 40455 | 1642 | 34914822 |
Respiratory acidosis | 11.70 | 11.06 | 21 | 40446 | 5029 | 34911435 |
Thrombocytopenia | 11.68 | 11.06 | 120 | 40347 | 156127 | 34760337 |
Cryoglobulinaemia | 11.64 | 11.06 | 7 | 40460 | 448 | 34916016 |
Stoma site haemorrhage | 11.54 | 11.06 | 9 | 40458 | 881 | 34915583 |
Hyperkalaemia | 11.53 | 11.06 | 127 | 40340 | 69262 | 34847202 |
Respiratory syncytial virus infection | 11.45 | 11.06 | 20 | 40447 | 4689 | 34911775 |
Myelosuppression | 11.43 | 11.06 | 4 | 40463 | 19261 | 34897203 |
Secondary hypogonadism | 11.41 | 11.06 | 6 | 40461 | 296 | 34916168 |
Hemiplegia | 11.34 | 11.06 | 25 | 40442 | 6947 | 34909517 |
Radicular pain | 11.31 | 11.06 | 4 | 40463 | 73 | 34916391 |
Dysmorphism | 11.29 | 11.06 | 16 | 40451 | 3140 | 34913324 |
Panic attack | 11.25 | 11.06 | 30 | 40437 | 9402 | 34907062 |
Migraine | 11.21 | 11.06 | 45 | 40422 | 17433 | 34899031 |
Respiratory dyskinesia | 11.20 | 11.06 | 3 | 40464 | 20 | 34916444 |
Amyotrophy | 11.20 | 11.06 | 7 | 40460 | 480 | 34915984 |
Constipation | 11.17 | 11.06 | 103 | 40364 | 136879 | 34779585 |
Acute myocardial infarction | 11.08 | 11.06 | 29 | 40438 | 53690 | 34862774 |
Intentional product use issue | 11.08 | 11.06 | 34 | 40433 | 59782 | 34856682 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1128.96 | 10.07 | 1418 | 92711 | 244349 | 79405910 |
Bradycardia | 584.51 | 10.07 | 759 | 93370 | 134798 | 79515461 |
Product administered to patient of inappropriate age | 570.32 | 10.07 | 223 | 93906 | 5330 | 79644929 |
Toxicity to various agents | 518.19 | 10.07 | 1369 | 92760 | 420171 | 79230088 |
Cardiac arrest | 388.02 | 10.07 | 714 | 93415 | 171382 | 79478877 |
Drug ineffective for unapproved indication | 350.29 | 10.07 | 364 | 93765 | 50874 | 79599385 |
Intentional overdose | 317.29 | 10.07 | 499 | 93630 | 105461 | 79544798 |
Overdose | 231.33 | 10.07 | 604 | 93525 | 183602 | 79466657 |
Product use in unapproved indication | 229.41 | 10.07 | 733 | 93396 | 249626 | 79400633 |
Hepatic encephalopathy | 210.43 | 10.07 | 196 | 93933 | 23970 | 79626289 |
Cardio-respiratory arrest | 206.13 | 10.07 | 419 | 93710 | 108091 | 79542168 |
Coma | 195.17 | 10.07 | 392 | 93737 | 100257 | 79550002 |
Product use issue | 194.58 | 10.07 | 617 | 93512 | 209205 | 79441054 |
Drug interaction | 176.06 | 10.07 | 959 | 93170 | 414224 | 79236035 |
Respiratory arrest | 159.79 | 10.07 | 262 | 93867 | 57288 | 79592971 |
Hypotension | 156.07 | 10.07 | 970 | 93159 | 439347 | 79210912 |
Sinus bradycardia | 138.79 | 10.07 | 160 | 93969 | 25087 | 79625172 |
Poisoning deliberate | 138.12 | 10.07 | 139 | 93990 | 18689 | 79631570 |
Cardiogenic shock | 131.77 | 10.07 | 202 | 93927 | 41712 | 79608547 |
Nightmare | 125.84 | 10.07 | 154 | 93975 | 25707 | 79624552 |
Electrocardiogram QRS complex prolonged | 120.56 | 10.07 | 101 | 94028 | 10732 | 79639527 |
Suicide attempt | 117.64 | 10.07 | 285 | 93844 | 82647 | 79567612 |
Hepatocellular carcinoma | 112.78 | 10.07 | 90 | 94039 | 8931 | 79641328 |
Hand deformity | 108.61 | 10.07 | 3 | 94126 | 103916 | 79546343 |
Electrocardiogram QT prolonged | 101.89 | 10.07 | 285 | 93844 | 90101 | 79560158 |
Brain injury | 99.46 | 10.07 | 93 | 94036 | 11424 | 79638835 |
Pulseless electrical activity | 99.24 | 10.07 | 102 | 94027 | 14058 | 79636201 |
Wound | 98.47 | 10.07 | 11 | 94118 | 116168 | 79534091 |
Hyperthyroidism | 96.51 | 10.07 | 125 | 94004 | 22084 | 79628175 |
Hypoglycaemia | 89.73 | 10.07 | 294 | 93835 | 101300 | 79548959 |
Varices oesophageal | 88.51 | 10.07 | 66 | 94063 | 5925 | 79644334 |
Febrile neutropenia | 87.62 | 10.07 | 86 | 94043 | 230913 | 79419346 |
Thyrotoxic crisis | 85.95 | 10.07 | 38 | 94091 | 1246 | 79649013 |
Hyperhidrosis | 85.48 | 10.07 | 380 | 93749 | 151112 | 79499147 |
Oesophageal varices haemorrhage | 84.30 | 10.07 | 56 | 94073 | 4180 | 79646079 |
Joint swelling | 83.78 | 10.07 | 132 | 93997 | 288514 | 79361745 |
Suicidal ideation | 83.38 | 10.07 | 238 | 93891 | 76102 | 79574157 |
Pericarditis | 83.17 | 10.07 | 12 | 94117 | 104224 | 79546035 |
Pneumonia | 81.13 | 10.07 | 453 | 93676 | 659793 | 78990466 |
Seizure | 81.02 | 10.07 | 438 | 93691 | 188396 | 79461863 |
Neovascularisation | 80.62 | 10.07 | 36 | 94093 | 1209 | 79649050 |
Glossodynia | 77.73 | 10.07 | 14 | 94115 | 103323 | 79546936 |
Akathisia | 74.51 | 10.07 | 85 | 94044 | 13174 | 79637085 |
Systemic lupus erythematosus | 74.48 | 10.07 | 25 | 94104 | 121124 | 79529135 |
Parasomnia | 73.78 | 10.07 | 27 | 94102 | 534 | 79649725 |
Lower respiratory tract infection | 72.21 | 10.07 | 31 | 94098 | 129189 | 79521070 |
Arthralgia | 71.47 | 10.07 | 390 | 93739 | 571413 | 79078846 |
Hypoglycaemic seizure | 70.43 | 10.07 | 29 | 94100 | 795 | 79649464 |
Somnolence | 70.27 | 10.07 | 503 | 93626 | 238478 | 79411781 |
Thyrotoxic periodic paralysis | 68.69 | 10.07 | 19 | 94110 | 142 | 79650117 |
Circulatory collapse | 66.24 | 10.07 | 141 | 93988 | 37527 | 79612732 |
Off label use | 65.82 | 10.07 | 1465 | 92664 | 905750 | 78744509 |
Nasopharyngitis | 64.67 | 10.07 | 126 | 94003 | 253755 | 79396504 |
Myokymia | 63.85 | 10.07 | 17 | 94112 | 108 | 79650151 |
Phaeochromocytoma | 62.24 | 10.07 | 25 | 94104 | 642 | 79649617 |
Stomatitis | 61.18 | 10.07 | 50 | 94079 | 146707 | 79503552 |
Tremor | 60.85 | 10.07 | 376 | 93753 | 169707 | 79480552 |
Rheumatoid arthritis | 60.78 | 10.07 | 95 | 94034 | 208375 | 79441884 |
Infection | 60.66 | 10.07 | 121 | 94008 | 241591 | 79408668 |
Pain | 60.35 | 10.07 | 536 | 93593 | 703266 | 78946993 |
Swelling | 60.15 | 10.07 | 102 | 94027 | 216609 | 79433650 |
Synovitis | 59.62 | 10.07 | 54 | 94075 | 150680 | 79499579 |
Peripheral coldness | 58.90 | 10.07 | 83 | 94046 | 15887 | 79634372 |
Disease progression | 58.67 | 10.07 | 79 | 94050 | 184283 | 79465976 |
Disturbance in attention | 58.03 | 10.07 | 161 | 93968 | 50640 | 79599619 |
Extrapyramidal disorder | 57.27 | 10.07 | 99 | 94030 | 22580 | 79627679 |
Hallucination, auditory | 57.13 | 10.07 | 94 | 94035 | 20599 | 79629660 |
Pyrexia | 55.95 | 10.07 | 522 | 93607 | 678187 | 78972072 |
Neuropathy peripheral | 55.43 | 10.07 | 51 | 94078 | 141254 | 79509005 |
Drug withdrawal syndrome | 55.42 | 10.07 | 125 | 94004 | 34593 | 79615666 |
Peripheral swelling | 54.82 | 10.07 | 151 | 93978 | 269466 | 79380793 |
Suspected suicide | 54.75 | 10.07 | 65 | 94064 | 10511 | 79639748 |
Electrocardiogram QRS complex shortened | 53.41 | 10.07 | 23 | 94106 | 707 | 79649552 |
Helicobacter infection | 53.39 | 10.07 | 9 | 94120 | 69695 | 79580564 |
Migraine | 52.78 | 10.07 | 224 | 93905 | 87269 | 79562990 |
Depressed level of consciousness | 49.71 | 10.07 | 236 | 93893 | 96416 | 79553843 |
Shock | 48.74 | 10.07 | 137 | 93992 | 43411 | 79606848 |
Infusion related reaction | 48.26 | 10.07 | 127 | 94002 | 230110 | 79420149 |
Alopecia | 48.21 | 10.07 | 128 | 94001 | 231227 | 79419032 |
Product used for unknown indication | 47.61 | 10.07 | 27 | 94102 | 1517 | 79648742 |
Ascites | 47.57 | 10.07 | 196 | 93933 | 75366 | 79574893 |
Anuria | 47.15 | 10.07 | 87 | 94042 | 20876 | 79629383 |
Encapsulating peritoneal sclerosis | 46.91 | 10.07 | 22 | 94107 | 829 | 79649430 |
Hallucination | 46.77 | 10.07 | 213 | 93916 | 85532 | 79564727 |
Pain in extremity | 46.37 | 10.07 | 247 | 93882 | 364291 | 79285968 |
Generalised tonic-clonic seizure | 46.10 | 10.07 | 135 | 93994 | 43775 | 79606484 |
Impaired healing | 45.92 | 10.07 | 23 | 94106 | 87632 | 79562627 |
Arthropathy | 45.87 | 10.07 | 87 | 94042 | 177024 | 79473235 |
Agitation | 44.57 | 10.07 | 234 | 93895 | 99481 | 79550778 |
Depression | 43.15 | 10.07 | 418 | 93711 | 216372 | 79433887 |
Muscle injury | 42.69 | 10.07 | 4 | 94125 | 48557 | 79601702 |
Paradoxical drug reaction | 41.97 | 10.07 | 47 | 94082 | 7138 | 79643121 |
Hepatorenal syndrome | 41.96 | 10.07 | 37 | 94092 | 4212 | 79646047 |
Irritability | 41.77 | 10.07 | 125 | 94004 | 41019 | 79609240 |
Rash | 40.94 | 10.07 | 461 | 93668 | 577897 | 79072362 |
Somatic delusion | 40.94 | 10.07 | 19 | 94110 | 699 | 79649560 |
Atrioventricular block first degree | 40.38 | 10.07 | 61 | 94068 | 12430 | 79637829 |
Suicidal behaviour | 39.75 | 10.07 | 32 | 94097 | 3215 | 79647044 |
Coma scale abnormal | 39.52 | 10.07 | 50 | 94079 | 8628 | 79641631 |
Alcohol interaction | 39.50 | 10.07 | 38 | 94091 | 4836 | 79645423 |
Intentional product use issue | 37.41 | 10.07 | 77 | 94052 | 152035 | 79498224 |
Areflexia | 37.22 | 10.07 | 39 | 94090 | 5495 | 79644764 |
Mobility decreased | 37.21 | 10.07 | 54 | 94075 | 122121 | 79528138 |
Sleep disorder due to general medical condition, insomnia type | 37.21 | 10.07 | 4 | 94125 | 43552 | 79606707 |
Sinusitis | 37.16 | 10.07 | 113 | 94016 | 195388 | 79454871 |
Torsade de pointes | 37.13 | 10.07 | 75 | 94054 | 19237 | 79631022 |
Interstitial lung disease | 37.09 | 10.07 | 47 | 94082 | 112553 | 79537706 |
Infantile spitting up | 36.85 | 10.07 | 8 | 94121 | 17 | 79650242 |
Brain scan abnormal | 36.67 | 10.07 | 21 | 94108 | 1202 | 79649057 |
Myocardial depression | 36.52 | 10.07 | 16 | 94113 | 513 | 79649746 |
Cerebral artery thrombosis | 35.81 | 10.07 | 20 | 94109 | 1091 | 79649168 |
Atrioventricular block | 35.07 | 10.07 | 61 | 94068 | 13980 | 79636279 |
Granulomatous rosacea | 34.47 | 10.07 | 12 | 94117 | 204 | 79650055 |
Serotonin syndrome | 34.23 | 10.07 | 124 | 94005 | 44903 | 79605356 |
Respiratory depression | 33.99 | 10.07 | 90 | 94039 | 27540 | 79622719 |
Therapeutic product effect decreased | 33.86 | 10.07 | 91 | 94038 | 163772 | 79486487 |
Lethargy | 33.77 | 10.07 | 187 | 93942 | 81105 | 79569154 |
Herpes zoster | 33.73 | 10.07 | 36 | 94093 | 93047 | 79557212 |
Metabolic acidosis | 33.72 | 10.07 | 189 | 93940 | 82340 | 79567919 |
Accessory cardiac pathway | 33.60 | 10.07 | 7 | 94122 | 11 | 79650248 |
Withdrawal syndrome | 33.57 | 10.07 | 88 | 94041 | 26766 | 79623493 |
Loss of consciousness | 33.50 | 10.07 | 324 | 93805 | 167619 | 79482640 |
Panic attack | 33.02 | 10.07 | 82 | 94047 | 24134 | 79626125 |
Hypermobility syndrome | 32.96 | 10.07 | 15 | 94114 | 527 | 79649732 |
Brain death | 32.93 | 10.07 | 37 | 94092 | 5640 | 79644619 |
Dyspnoea | 32.90 | 10.07 | 766 | 93363 | 856259 | 78794000 |
Hepatic cirrhosis | 32.60 | 10.07 | 103 | 94026 | 34803 | 79615456 |
Nephrolithiasis | 32.57 | 10.07 | 137 | 93992 | 53154 | 79597105 |
Galactorrhoea | 32.56 | 10.07 | 30 | 94099 | 3616 | 79646643 |
Productive cough | 32.19 | 10.07 | 34 | 94095 | 88297 | 79561962 |
Haemoglobin decreased | 31.97 | 10.07 | 144 | 93985 | 221975 | 79428284 |
Hallucination, visual | 31.88 | 10.07 | 98 | 94031 | 32631 | 79617628 |
Granulocytopenia | 31.65 | 10.07 | 52 | 94077 | 11379 | 79638880 |
Malignant neoplasm progression | 31.65 | 10.07 | 71 | 94058 | 135919 | 79514340 |
Myelosuppression | 31.31 | 10.07 | 5 | 94124 | 40291 | 79609968 |
Gastrointestinal disorder | 30.79 | 10.07 | 61 | 94068 | 122144 | 79528115 |
Abdominal discomfort | 30.69 | 10.07 | 172 | 93957 | 250555 | 79399704 |
Tardive dyskinesia | 30.51 | 10.07 | 49 | 94080 | 10522 | 79639737 |
Phonophobia | 30.50 | 10.07 | 14 | 94115 | 502 | 79649757 |
Hepatitis C | 30.04 | 10.07 | 52 | 94077 | 11873 | 79638386 |
Reversible airways obstruction | 29.99 | 10.07 | 23 | 94106 | 2153 | 79648106 |
Antipsychotic drug level increased | 29.83 | 10.07 | 36 | 94093 | 5921 | 79644338 |
Distributive shock | 29.79 | 10.07 | 25 | 94104 | 2662 | 79647597 |
Ventricular arrhythmia | 29.76 | 10.07 | 44 | 94085 | 8796 | 79641463 |
Neutropenia | 29.73 | 10.07 | 208 | 93921 | 287502 | 79362757 |
Swollen tongue | 29.66 | 10.07 | 114 | 94015 | 42456 | 79607803 |
Psychotic disorder | 28.95 | 10.07 | 111 | 94018 | 41291 | 79608968 |
Sepsis | 27.73 | 10.07 | 195 | 93934 | 269233 | 79381026 |
Sedation | 27.61 | 10.07 | 128 | 94001 | 51767 | 79598492 |
Phaeochromocytoma malignant | 27.61 | 10.07 | 8 | 94121 | 72 | 79650187 |
Migraine with aura | 27.61 | 10.07 | 24 | 94105 | 2681 | 79647578 |
Vascular malformation | 27.36 | 10.07 | 12 | 94117 | 386 | 79649873 |
Encephalopathy | 27.30 | 10.07 | 154 | 93975 | 67243 | 79583016 |
Blister | 27.29 | 10.07 | 63 | 94066 | 119413 | 79530846 |
Insomnia | 27.05 | 10.07 | 423 | 93706 | 244747 | 79405512 |
Negative symptoms in schizophrenia | 26.42 | 10.07 | 9 | 94120 | 143 | 79650116 |
Platelet count decreased | 26.36 | 10.07 | 129 | 94000 | 194535 | 79455724 |
Anxiety | 26.00 | 10.07 | 425 | 93704 | 248087 | 79402172 |
Thyroxine free decreased | 25.93 | 10.07 | 16 | 94113 | 1051 | 79649208 |
Hepatic enzyme increased | 25.91 | 10.07 | 119 | 94010 | 182491 | 79467768 |
Paranasal cyst | 25.82 | 10.07 | 12 | 94117 | 443 | 79649816 |
Oedema | 25.78 | 10.07 | 65 | 94064 | 119515 | 79530744 |
Vision blurred | 25.57 | 10.07 | 213 | 93916 | 105685 | 79544574 |
Intentional self-injury | 25.25 | 10.07 | 90 | 94039 | 32329 | 79617930 |
Vasoplegia syndrome | 25.17 | 10.07 | 26 | 94103 | 3604 | 79646655 |
Discomfort | 25.02 | 10.07 | 71 | 94058 | 125546 | 79524713 |
Poisoning | 24.92 | 10.07 | 76 | 94053 | 25196 | 79625063 |
Agranulocytosis | 24.65 | 10.07 | 112 | 94017 | 44918 | 79605341 |
Alcoholism | 24.62 | 10.07 | 26 | 94103 | 3697 | 79646562 |
Neutrophil count decreased | 24.45 | 10.07 | 46 | 94083 | 93913 | 79556346 |
Musculoskeletal pain | 24.17 | 10.07 | 53 | 94076 | 102301 | 79547958 |
Cyanosis | 24.15 | 10.07 | 75 | 94054 | 25107 | 79625152 |
Infusion site streaking | 24.12 | 10.07 | 12 | 94117 | 516 | 79649743 |
Joint range of motion decreased | 23.99 | 10.07 | 5 | 94124 | 33277 | 79616982 |
Gastroenteritis eosinophilic | 23.60 | 10.07 | 10 | 94119 | 295 | 79649964 |
Bradycardia foetal | 23.55 | 10.07 | 8 | 94121 | 126 | 79650133 |
Knee arthroplasty | 23.17 | 10.07 | 11 | 94118 | 43237 | 79607022 |
Hyperreflexia | 23.02 | 10.07 | 38 | 94091 | 8347 | 79641912 |
Thyrotoxic cardiomyopathy | 22.97 | 10.07 | 4 | 94125 | 0 | 79650259 |
Derailment | 22.90 | 10.07 | 7 | 94122 | 77 | 79650182 |
Back pain | 22.85 | 10.07 | 239 | 93890 | 303941 | 79346318 |
Therapeutic product effect incomplete | 22.75 | 10.07 | 88 | 94041 | 141557 | 79508702 |
Blood lactic acid increased | 22.74 | 10.07 | 48 | 94081 | 12696 | 79637563 |
Hip arthroplasty | 22.64 | 10.07 | 7 | 94122 | 35749 | 79614510 |
Blood pressure systolic decreased | 22.48 | 10.07 | 44 | 94085 | 11032 | 79639227 |
Palpitations | 22.24 | 10.07 | 238 | 93891 | 126372 | 79523887 |
Ill-defined disorder | 22.21 | 10.07 | 27 | 94102 | 65848 | 79584411 |
Disorientation | 21.94 | 10.07 | 138 | 93991 | 62638 | 79587621 |
Neuroleptic malignant syndrome | 21.89 | 10.07 | 77 | 94052 | 27482 | 79622777 |
Depressed mood | 21.81 | 10.07 | 114 | 94015 | 48366 | 79601893 |
Haematemesis | 21.55 | 10.07 | 120 | 94009 | 52144 | 79598115 |
Irritable bowel syndrome | 21.53 | 10.07 | 25 | 94104 | 62216 | 79588043 |
Thyroxine free increased | 21.46 | 10.07 | 15 | 94114 | 1217 | 79649042 |
Chronic obstructive pulmonary disease | 21.20 | 10.07 | 43 | 94086 | 85376 | 79564883 |
Cytomegalovirus infection | 21.14 | 10.07 | 12 | 94117 | 42632 | 79607627 |
Portal vein thrombosis | 21.07 | 10.07 | 30 | 94099 | 5797 | 79644462 |
Wheezing | 21.05 | 10.07 | 69 | 94060 | 116595 | 79533664 |
Hyperammonaemic encephalopathy | 20.91 | 10.07 | 27 | 94102 | 4755 | 79645504 |
Blood cholesterol increased | 20.90 | 10.07 | 42 | 94087 | 83678 | 79566581 |
Abnormal sleep-related event | 20.77 | 10.07 | 13 | 94116 | 876 | 79649383 |
Cerebral disorder | 20.75 | 10.07 | 29 | 94100 | 5509 | 79644750 |
Bronchitis | 20.45 | 10.07 | 82 | 94047 | 130562 | 79519697 |
Drug withdrawal syndrome neonatal | 20.39 | 10.07 | 9 | 94120 | 294 | 79649965 |
Therapeutic product ineffective for unapproved indication | 20.38 | 10.07 | 8 | 94121 | 193 | 79650066 |
Aggression | 20.35 | 10.07 | 116 | 94013 | 50842 | 79599417 |
Hypothermia | 20.22 | 10.07 | 66 | 94063 | 22680 | 79627579 |
Prostate cancer | 20.20 | 10.07 | 7 | 94122 | 33261 | 79616998 |
Renal impairment | 19.98 | 10.07 | 107 | 94022 | 157676 | 79492583 |
Pruritus | 19.82 | 10.07 | 337 | 93792 | 394311 | 79255948 |
Respiratory acidosis | 19.77 | 10.07 | 42 | 94087 | 11158 | 79639101 |
Mucosal inflammation | 19.66 | 10.07 | 37 | 94092 | 75543 | 79574716 |
Intentional product misuse | 19.66 | 10.07 | 185 | 93944 | 94980 | 79555279 |
Portal hypertensive gastropathy | 19.61 | 10.07 | 15 | 94114 | 1399 | 79648860 |
Cytokine release syndrome | 19.53 | 10.07 | 9 | 94120 | 35989 | 79614270 |
Cholestasis of pregnancy | 19.45 | 10.07 | 13 | 94116 | 980 | 79649279 |
Gross motor delay | 19.44 | 10.07 | 7 | 94122 | 132 | 79650127 |
Eosinophilic myocarditis | 19.26 | 10.07 | 14 | 94115 | 1208 | 79649051 |
Muscle contractions involuntary | 19.26 | 10.07 | 23 | 94106 | 3742 | 79646517 |
Porphyrins urine increased | 19.17 | 10.07 | 5 | 94124 | 29 | 79650230 |
Tinnitus | 19.09 | 10.07 | 103 | 94026 | 44230 | 79606029 |
Oesophageal obstruction | 19.07 | 10.07 | 13 | 94116 | 1013 | 79649246 |
Mood swings | 18.87 | 10.07 | 59 | 94070 | 19821 | 79630438 |
Bradypnoea | 18.78 | 10.07 | 29 | 94100 | 6023 | 79644236 |
Teratogenicity | 18.66 | 10.07 | 8 | 94121 | 243 | 79650016 |
Hepatitis C RNA positive | 18.60 | 10.07 | 8 | 94121 | 245 | 79650014 |
Pupil fixed | 18.59 | 10.07 | 22 | 94107 | 3544 | 79646715 |
Atrial fibrillation | 18.55 | 10.07 | 147 | 93982 | 197739 | 79452520 |
Poor quality sleep | 18.49 | 10.07 | 64 | 94065 | 22658 | 79627601 |
Lung neoplasm malignant | 18.40 | 10.07 | 5 | 94124 | 27787 | 79622472 |
Drug dispensed to wrong patient | 18.22 | 10.07 | 11 | 94118 | 695 | 79649564 |
Cutaneous lupus erythematosus | 18.15 | 10.07 | 20 | 94109 | 2983 | 79647276 |
Acquired porphyria | 18.12 | 10.07 | 5 | 94124 | 37 | 79650222 |
Sexually inappropriate behaviour | 18.08 | 10.07 | 10 | 94119 | 535 | 79649724 |
Granuloma skin | 18.08 | 10.07 | 36 | 94093 | 9138 | 79641121 |
Cerebellar syndrome | 18.05 | 10.07 | 27 | 94102 | 5453 | 79644806 |
Dystonia | 18.05 | 10.07 | 61 | 94068 | 21338 | 79628921 |
Fatigue | 17.96 | 10.07 | 906 | 93223 | 928821 | 78721438 |
Confusional state | 17.67 | 10.07 | 496 | 93633 | 317501 | 79332758 |
Urine amphetamine positive | 17.46 | 10.07 | 6 | 94123 | 98 | 79650161 |
Porphyrins stool increased | 17.36 | 10.07 | 5 | 94124 | 44 | 79650215 |
Insulin autoimmune syndrome | 17.35 | 10.07 | 9 | 94120 | 423 | 79649836 |
Wrong strength | 17.35 | 10.07 | 7 | 94122 | 182 | 79650077 |
Mydriasis | 17.34 | 10.07 | 53 | 94076 | 17590 | 79632669 |
Mental disorder | 17.24 | 10.07 | 78 | 94051 | 31224 | 79619035 |
Hypnagogic hallucination | 17.17 | 10.07 | 7 | 94122 | 187 | 79650072 |
Acute stress disorder | 17.11 | 10.07 | 9 | 94120 | 435 | 79649824 |
Altered state of consciousness | 17.00 | 10.07 | 99 | 94030 | 43723 | 79606536 |
Hepatopulmonary syndrome | 16.97 | 10.07 | 5 | 94124 | 48 | 79650211 |
Therapeutic product effective for unapproved indication | 16.82 | 10.07 | 6 | 94123 | 110 | 79650149 |
Hyperprolactinaemia | 16.80 | 10.07 | 24 | 94105 | 4652 | 79645607 |
Unresponsive to stimuli | 16.69 | 10.07 | 118 | 94011 | 55670 | 79594589 |
Hyperthermia | 16.63 | 10.07 | 53 | 94076 | 17984 | 79632275 |
Sleep paralysis | 16.62 | 10.07 | 10 | 94119 | 628 | 79649631 |
Atrioventricular septal defect | 16.57 | 10.07 | 6 | 94123 | 115 | 79650144 |
Pituitary apoplexy | 16.54 | 10.07 | 7 | 94122 | 206 | 79650053 |
Dissociation | 16.49 | 10.07 | 22 | 94107 | 3999 | 79646260 |
Drooling | 16.44 | 10.07 | 27 | 94102 | 5907 | 79644352 |
Bezoar | 16.42 | 10.07 | 18 | 94111 | 2670 | 79647589 |
Psychotic symptom | 16.37 | 10.07 | 18 | 94111 | 2679 | 79647580 |
Grip strength decreased | 16.36 | 10.07 | 3 | 94126 | 21866 | 79628393 |
Acute myeloid leukaemia | 16.33 | 10.07 | 8 | 94121 | 30877 | 79619382 |
Myocardial infarction | 16.24 | 10.07 | 139 | 93990 | 183990 | 79466269 |
Osteoarthritis | 16.20 | 10.07 | 51 | 94078 | 87258 | 79563001 |
Feeling guilty | 16.14 | 10.07 | 11 | 94118 | 857 | 79649402 |
Persecutory delusion | 15.90 | 10.07 | 24 | 94105 | 4885 | 79645374 |
Exposure via transplant | 15.83 | 10.07 | 4 | 94125 | 20 | 79650239 |
Somnambulism | 15.81 | 10.07 | 26 | 94103 | 5695 | 79644564 |
Hepatic failure | 15.79 | 10.07 | 125 | 94004 | 61087 | 79589172 |
Nodal rhythm | 15.79 | 10.07 | 19 | 94110 | 3116 | 79647143 |
Oesophageal variceal ligation | 15.72 | 10.07 | 6 | 94123 | 134 | 79650125 |
Heart rate decreased | 15.69 | 10.07 | 139 | 93990 | 70177 | 79580082 |
Thrombosis | 15.69 | 10.07 | 49 | 94080 | 84051 | 79566208 |
Pneumonitis | 15.65 | 10.07 | 30 | 94099 | 60830 | 79589429 |
Medication overuse headache | 15.64 | 10.07 | 11 | 94118 | 901 | 79649358 |
Blood creatinine increased | 15.56 | 10.07 | 113 | 94016 | 154944 | 79495315 |
Pleural effusion | 15.49 | 10.07 | 104 | 94025 | 145158 | 79505101 |
Musculoskeletal stiffness | 15.49 | 10.07 | 132 | 93997 | 174876 | 79475383 |
Apraxia | 15.47 | 10.07 | 18 | 94111 | 2849 | 79647410 |
Red blood cell sedimentation rate abnormal | 15.42 | 10.07 | 3 | 94126 | 20960 | 79629299 |
Ventricular failure | 15.39 | 10.07 | 9 | 94120 | 536 | 79649723 |
Obstructive airways disorder | 15.38 | 10.07 | 9 | 94120 | 31450 | 79618809 |
Death | 15.37 | 10.07 | 531 | 93598 | 565983 | 79084276 |
Basedow's disease | 15.25 | 10.07 | 7 | 94122 | 251 | 79650008 |
Hyponatraemic seizure | 15.24 | 10.07 | 9 | 94120 | 546 | 79649713 |
Bursitis | 15.19 | 10.07 | 12 | 94117 | 35832 | 79614427 |
Distractibility | 15.19 | 10.07 | 10 | 94119 | 735 | 79649524 |
Salivary hypersecretion | 15.18 | 10.07 | 44 | 94085 | 14180 | 79636079 |
Perseveration | 15.17 | 10.07 | 8 | 94121 | 389 | 79649870 |
Obsessive-compulsive disorder | 15.13 | 10.07 | 26 | 94103 | 5901 | 79644358 |
Hypovolaemic shock | 15.11 | 10.07 | 40 | 94089 | 12236 | 79638023 |
Blood prolactin increased | 15.02 | 10.07 | 21 | 94108 | 3990 | 79646269 |
Headache | 14.99 | 10.07 | 928 | 93201 | 652844 | 78997415 |
Maternal exposure during pregnancy | 14.94 | 10.07 | 97 | 94032 | 136441 | 79513818 |
White blood cell count decreased | 14.93 | 10.07 | 146 | 93983 | 188142 | 79462117 |
Jaundice | 14.90 | 10.07 | 111 | 94018 | 53238 | 79597021 |
Hypertrophic cardiomyopathy | 14.87 | 10.07 | 16 | 94113 | 2324 | 79647935 |
Hypoaesthesia eye | 14.75 | 10.07 | 7 | 94122 | 271 | 79649988 |
Blood parathyroid hormone decreased | 14.70 | 10.07 | 36 | 94093 | 10500 | 79639759 |
Chemical burn | 14.69 | 10.07 | 9 | 94120 | 584 | 79649675 |
Pancytopenia | 14.67 | 10.07 | 125 | 94004 | 165620 | 79484639 |
Cardiac failure congestive | 14.67 | 10.07 | 103 | 94026 | 142299 | 79507960 |
Hyponatraemia | 14.65 | 10.07 | 293 | 93836 | 177555 | 79472704 |
Pulmonary mass | 14.64 | 10.07 | 8 | 94121 | 29026 | 79621233 |
Septic shock | 14.60 | 10.07 | 85 | 94044 | 122716 | 79527543 |
Sudden infant death syndrome | 14.58 | 10.07 | 7 | 94122 | 278 | 79649981 |
Muscle rigidity | 14.47 | 10.07 | 54 | 94075 | 19828 | 79630431 |
Rhinorrhoea | 14.42 | 10.07 | 44 | 94085 | 76030 | 79574229 |
Lip swelling | 14.33 | 10.07 | 90 | 94039 | 40821 | 79609438 |
Sputum discoloured | 14.23 | 10.07 | 4 | 94125 | 21739 | 79628520 |
Urinary tract infection | 14.23 | 10.07 | 233 | 93896 | 274279 | 79375980 |
Laryngeal dyspnoea | 14.22 | 10.07 | 7 | 94122 | 294 | 79649965 |
Pseudoporphyria | 14.21 | 10.07 | 9 | 94120 | 619 | 79649640 |
Abdominal cavity drainage | 14.21 | 10.07 | 10 | 94119 | 820 | 79649439 |
Narrow anterior chamber angle | 14.19 | 10.07 | 6 | 94123 | 176 | 79650083 |
Yellow skin | 14.10 | 10.07 | 19 | 94110 | 3486 | 79646773 |
Paraganglion neoplasm | 14.01 | 10.07 | 4 | 94125 | 34 | 79650225 |
Enuresis | 13.99 | 10.07 | 18 | 94111 | 3158 | 79647101 |
Peritoneal fibrosis | 13.94 | 10.07 | 3 | 94126 | 6 | 79650253 |
Right aortic arch | 13.94 | 10.07 | 3 | 94126 | 6 | 79650253 |
Drug intolerance | 13.85 | 10.07 | 409 | 93720 | 263710 | 79386549 |
Fibromyalgia | 13.84 | 10.07 | 35 | 94094 | 64305 | 79585954 |
Sinoatrial block | 13.81 | 10.07 | 12 | 94117 | 1339 | 79648920 |
Hyperkalaemia | 13.62 | 10.07 | 200 | 93929 | 114198 | 79536061 |
Exposure via ingestion | 13.61 | 10.07 | 23 | 94106 | 5151 | 79645108 |
Palmar erythema | 13.60 | 10.07 | 14 | 94115 | 1933 | 79648326 |
Food craving | 13.58 | 10.07 | 13 | 94116 | 1644 | 79648615 |
Dizziness | 13.53 | 10.07 | 755 | 93374 | 525686 | 79124573 |
Hallucinations, mixed | 13.51 | 10.07 | 27 | 94102 | 6872 | 79643387 |
Cognitive disorder | 13.49 | 10.07 | 134 | 93995 | 69792 | 79580467 |
Adrenal suppression | 13.45 | 10.07 | 12 | 94117 | 1387 | 79648872 |
Alcohol use | 13.41 | 10.07 | 22 | 94107 | 4809 | 79645450 |
Retroperitoneal fibrosis | 13.40 | 10.07 | 9 | 94120 | 684 | 79649575 |
International normalised ratio increased | 13.37 | 10.07 | 53 | 94076 | 84668 | 79565591 |
Sleep terror | 13.33 | 10.07 | 21 | 94108 | 4437 | 79645822 |
Psychomotor hyperactivity | 13.31 | 10.07 | 47 | 94082 | 16802 | 79633457 |
Gastrointestinal motility disorder | 13.26 | 10.07 | 25 | 94104 | 6097 | 79644162 |
Blood pressure systolic increased | 13.23 | 10.07 | 38 | 94091 | 66948 | 79583311 |
Blood thyroid stimulating hormone decreased | 13.20 | 10.07 | 24 | 94105 | 5692 | 79644567 |
Procedural hypotension | 13.15 | 10.07 | 14 | 94115 | 2009 | 79648250 |
Type 2 diabetes mellitus | 13.14 | 10.07 | 30 | 94099 | 57092 | 79593167 |
Bronchiectasis | 13.10 | 10.07 | 5 | 94124 | 22381 | 79627878 |
Psychomotor retardation | 13.08 | 10.07 | 25 | 94104 | 6159 | 79644100 |
Oxygen saturation decreased | 12.97 | 10.07 | 94 | 94035 | 128953 | 79521306 |
Hypotonia | 12.97 | 10.07 | 39 | 94090 | 12831 | 79637428 |
Hypervolaemia | 12.86 | 10.07 | 19 | 94110 | 42671 | 79607588 |
Gastric varices | 12.86 | 10.07 | 9 | 94120 | 732 | 79649527 |
Differential white blood cell count abnormal | 12.84 | 10.07 | 14 | 94115 | 2063 | 79648196 |
Hyperbilirubinaemia | 12.69 | 10.07 | 60 | 94069 | 24458 | 79625801 |
Meconium in amniotic fluid | 12.69 | 10.07 | 5 | 94124 | 122 | 79650137 |
Withdrawal hypertension | 12.61 | 10.07 | 7 | 94122 | 377 | 79649882 |
Chromaturia | 12.60 | 10.07 | 62 | 94067 | 25684 | 79624575 |
Drug level increased | 12.53 | 10.07 | 85 | 94044 | 39566 | 79610693 |
Bone marrow failure | 12.45 | 10.07 | 26 | 94103 | 51081 | 79599178 |
Aspiration of gastric residual | 12.42 | 10.07 | 3 | 94126 | 12 | 79650247 |
Myoclonus | 12.41 | 10.07 | 65 | 94064 | 27595 | 79622664 |
Joint effusion | 12.39 | 10.07 | 3 | 94126 | 18011 | 79632248 |
Memory impairment | 12.39 | 10.07 | 193 | 93936 | 111541 | 79538718 |
Agoraphobia | 12.38 | 10.07 | 8 | 94121 | 570 | 79649689 |
Contusion | 12.38 | 10.07 | 114 | 94015 | 148662 | 79501597 |
Essential tremor | 12.37 | 10.07 | 12 | 94117 | 1543 | 79648716 |
Lung disorder | 12.33 | 10.07 | 51 | 94078 | 80506 | 79569753 |
Affective disorder | 12.23 | 10.07 | 29 | 94100 | 8290 | 79641969 |
Genotype drug resistance test positive | 12.14 | 10.07 | 11 | 94118 | 1297 | 79648962 |
Heart rate variability increased | 12.14 | 10.07 | 4 | 94125 | 57 | 79650202 |
Transfusion | 12.10 | 10.07 | 5 | 94124 | 21325 | 79628934 |
Anaemia | 12.08 | 10.07 | 417 | 93712 | 444598 | 79205661 |
Cough | 12.08 | 10.07 | 335 | 93794 | 366454 | 79283805 |
Panniculitis | 12.01 | 10.07 | 37 | 94092 | 12334 | 79637925 |
Transplant rejection | 11.96 | 10.07 | 4 | 94125 | 19433 | 79630826 |
Bleeding varicose vein | 11.88 | 10.07 | 8 | 94121 | 611 | 79649648 |
Pneumonia bacterial | 11.86 | 10.07 | 4 | 94125 | 19327 | 79630932 |
Drug tolerance decreased | 11.84 | 10.07 | 38 | 94091 | 12940 | 79637319 |
Dysarthria | 11.81 | 10.07 | 127 | 94002 | 67495 | 79582764 |
Blood pressure diastolic abnormal | 11.73 | 10.07 | 4 | 94125 | 19198 | 79631061 |
Basilar migraine | 11.66 | 10.07 | 4 | 94125 | 65 | 79650194 |
Growth hormone-producing pituitary tumour | 11.66 | 10.07 | 4 | 94125 | 65 | 79650194 |
Ear discomfort | 11.63 | 10.07 | 29 | 94100 | 8554 | 79641705 |
Breath holding | 11.60 | 10.07 | 4 | 94125 | 66 | 79650193 |
Ventricular tachycardia | 11.57 | 10.07 | 87 | 94042 | 41848 | 79608411 |
Gynaecomastia | 11.53 | 10.07 | 27 | 94102 | 7654 | 79642605 |
Negative thoughts | 11.51 | 10.07 | 11 | 94118 | 1388 | 79648871 |
Asthma | 11.46 | 10.07 | 103 | 94026 | 134992 | 79515267 |
Mastoiditis | 11.45 | 10.07 | 12 | 94117 | 1692 | 79648567 |
Bacterial infection | 11.44 | 10.07 | 12 | 94117 | 31268 | 79618991 |
COVID-19 | 11.38 | 10.07 | 125 | 94004 | 157549 | 79492710 |
Full blood count abnormal | 11.26 | 10.07 | 19 | 94110 | 40455 | 79609804 |
Goitre | 11.23 | 10.07 | 22 | 94107 | 5517 | 79644742 |
Facial paralysis | 11.23 | 10.07 | 52 | 94077 | 21020 | 79629239 |
Oral discomfort | 11.21 | 10.07 | 31 | 94098 | 9729 | 79640530 |
Cytopenia | 11.21 | 10.07 | 5 | 94124 | 20378 | 79629881 |
Neoplasm progression | 11.21 | 10.07 | 28 | 94101 | 51654 | 79598605 |
Alveolar bone resorption | 11.18 | 10.07 | 4 | 94125 | 74 | 79650185 |
Clostridium difficile colitis | 11.13 | 10.07 | 13 | 94116 | 32270 | 79617989 |
Right ventricular failure | 11.10 | 10.07 | 7 | 94122 | 23490 | 79626769 |
Meningitis streptococcal | 11.06 | 10.07 | 5 | 94124 | 173 | 79650086 |
Cerebral vasoconstriction | 11.05 | 10.07 | 11 | 94118 | 1459 | 79648800 |
Blood pressure immeasurable | 11.00 | 10.07 | 13 | 94116 | 2091 | 79648168 |
Apathy | 10.95 | 10.07 | 37 | 94092 | 12940 | 79637319 |
Abnormal behaviour | 10.87 | 10.07 | 77 | 94052 | 36344 | 79613915 |
Patient dissatisfaction with treatment | 10.85 | 10.07 | 5 | 94124 | 181 | 79650078 |
Respiratory rate decreased | 10.85 | 10.07 | 21 | 94108 | 5222 | 79645037 |
Vertigo | 10.82 | 10.07 | 127 | 94002 | 68955 | 79581304 |
Genital swelling | 10.80 | 10.07 | 6 | 94123 | 324 | 79649935 |
Antipsychotic drug level decreased | 10.79 | 10.07 | 10 | 94119 | 1214 | 79649045 |
Subdural hygroma | 10.79 | 10.07 | 7 | 94122 | 502 | 79649757 |
Thyroid cancer metastatic | 10.77 | 10.07 | 5 | 94124 | 184 | 79650075 |
Injection site pruritus | 10.74 | 10.07 | 21 | 94108 | 42262 | 79607997 |
Abnormal faeces | 10.70 | 10.07 | 26 | 94103 | 7545 | 79642714 |
Gastric hypomotility | 10.70 | 10.07 | 5 | 94124 | 187 | 79650072 |
Brugada syndrome | 10.69 | 10.07 | 10 | 94119 | 1228 | 79649031 |
Violence-related symptom | 10.68 | 10.07 | 8 | 94121 | 723 | 79649536 |
Blood growth hormone increased | 10.63 | 10.07 | 8 | 94121 | 728 | 79649531 |
Device related infection | 10.59 | 10.07 | 15 | 94114 | 34279 | 79615980 |
Monocyte count abnormal | 10.57 | 10.07 | 5 | 94124 | 192 | 79650067 |
Multiple lentigines syndrome | 10.50 | 10.07 | 5 | 94124 | 195 | 79650064 |
Electrocardiogram T wave inversion | 10.49 | 10.07 | 21 | 94108 | 5351 | 79644908 |
Urine odour abnormal | 10.47 | 10.07 | 23 | 94106 | 6250 | 79644009 |
Tonic convulsion | 10.44 | 10.07 | 13 | 94116 | 2207 | 79648052 |
Cardiotoxicity | 10.42 | 10.07 | 35 | 94094 | 12204 | 79638055 |
Tinea versicolour | 10.39 | 10.07 | 6 | 94123 | 349 | 79649910 |
Hypersensitivity | 10.39 | 10.07 | 233 | 93896 | 262006 | 79388253 |
Bundle branch block | 10.27 | 10.07 | 11 | 94118 | 1589 | 79648670 |
Haemorrhagic tumour necrosis | 10.26 | 10.07 | 3 | 94126 | 28 | 79650231 |
Wound infection | 10.21 | 10.07 | 8 | 94121 | 23983 | 79626276 |
Nervousness | 10.18 | 10.07 | 71 | 94058 | 33344 | 79616915 |
Secondary hypogonadism | 10.17 | 10.07 | 6 | 94123 | 363 | 79649896 |
Loss of bladder sensation | 10.17 | 10.07 | 4 | 94125 | 97 | 79650162 |
Sprue-like enteropathy | 10.16 | 10.07 | 10 | 94119 | 1308 | 79648951 |
Low cardiac output syndrome | 10.12 | 10.07 | 9 | 94120 | 1036 | 79649223 |
Primary adrenal insufficiency | 10.11 | 10.07 | 5 | 94124 | 212 | 79650047 |
Respiratory tract infection | 10.08 | 10.07 | 27 | 94102 | 48662 | 79601597 |
Tongue pruritus | 10.07 | 10.07 | 7 | 94122 | 563 | 79649696 |
None
Source | Code | Description |
---|---|---|
ATC | C07AA05 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, non-selective |
ATC | C07BA05 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND THIAZIDES Beta blocking agents, non-selective, and thiazides |
ATC | C07FX01 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents, other combinations |
FDA MoA | N0000000161 | Adrenergic beta-Antagonists |
FDA EPC | N0000175556 | beta-Adrenergic Blocker |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D000319 | Adrenergic beta-Antagonists |
MeSH PA | D000889 | Anti-Arrhythmia Agents |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014665 | Vasodilator Agents |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:35530 | beta-adrenergic blockers |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:85234 | human blood serum metabolites |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Supraventricular tachycardia | indication | 6456007 | |
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Atrial fibrillation | indication | 49436004 | DOID:0060224 |
Angina pectoris | indication | 194828000 | |
Hypertrophic cardiomyopathy | indication | 233873004 | DOID:11984 |
Idiopathic hypertrophic subaortic stenosis | indication | 360465008 | |
Hemangioma | indication | 400210000 | DOID:255 |
Essential tremor | indication | 609558009 | DOID:4990 |
Life-Threatening Ventricular Tachycardia | indication | ||
Ulcerated haemangioma | indication | ||
Proliferating infantile haemangioma requiring systemic therapy | indication | ||
Life or functionthreatening haemangioma | indication | ||
Haemangioma with a risk of permanent scars or disfigurement | indication | ||
Arrhythmias During Surgery | indication | ||
Pheochromocytoma Adjunct Therapy | indication | ||
Migraine Prevention | indication | ||
Myocardial Reinfarction Prevention | indication | ||
Thyrotoxicosis | off-label use | 90739004 | DOID:7997 |
Mitral valve prolapse | off-label use | 409712001 | |
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia | off-label use | ||
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation | off-label use | ||
Prevention of Bleeding Esophageal Varices | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Bronchospasm | contraindication | 4386001 | |
Hypercholesterolemia | contraindication | 13644009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Hypovolemia | contraindication | 28560003 | |
Dehydration | contraindication | 34095006 | |
Depressive disorder | contraindication | 35489007 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
Hypokalemia | contraindication | 43339004 | |
Sinus bradycardia | contraindication | 49710005 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Chronic bronchitis | contraindication | 63480004 | DOID:6132 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Wolff-Parkinson-White pattern | contraindication | 74390002 | DOID:384 |
Pulmonary emphysema | contraindication | 87433001 | |
Cardiogenic shock | contraindication | 89138009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Hypomagnesemia | contraindication | 190855004 | |
Second degree atrioventricular block | contraindication | 195042002 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypoglycemic disorder | contraindication | 237630007 | |
Raynaud's phenomenon | contraindication | 266261006 | |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
Azotemia | contraindication | 445009001 | |
Smokes tobacco daily | contraindication | 449868002 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.19 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
4.28MG/ML | HEMANGEOL | PIERRE FABRE DERMA | N205410 | March 14, 2014 | RX | SOLUTION | ORAL | 8338489 | Oct. 16, 2028 | METHOD TO TREAT HEMANGIOMA. |
4.28MG/ML | HEMANGEOL | PIERRE FABRE DERMA | N205410 | March 14, 2014 | RX | SOLUTION | ORAL | 8987262 | Oct. 16, 2028 | METHOD TO TREAT INFANTILE HEMANGIOMA |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Ki | 8.71 | WOMBAT-PK | DRUG LABEL | |||
Beta-2 adrenergic receptor | GPCR | ANTAGONIST | Ki | 8.25 | WOMBAT-PK | DRUG LABEL | |||
Multidrug resistance protein 1 | Transporter | Ki | 4.32 | CHEMBL | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 6.70 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.91 | PDSP | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 5.38 | PDSP | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 6.66 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 5.92 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.85 | DRUG MATRIX | |||||
Histamine H1 receptor | GPCR | Ki | 4.70 | WOMBAT-PK | |||||
Beta-3 adrenergic receptor | GPCR | ANTAGONIST | Ki | 6.22 | WOMBAT-PK | ||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 6.20 | PDSP | |||||
5-hydroxytryptamine receptor 1D | GPCR | Ki | 5.35 | PDSP | |||||
Cytochrome P450 2D6 | Enzyme | IC50 | 5.70 | DRUG MATRIX | |||||
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | Ki | 4.32 | WOMBAT-PK | |||||
Cytochrome P450 1A2 | Enzyme | IC50 | 5.40 | DRUG MATRIX | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.20 | CHEMBL | |||||
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Ion channel | IC50 | 4.30 | WOMBAT-PK | |||||
Nuclear receptor subfamily 2 group E member 1 | Nuclear hormone receptor | Kd | 6.30 | CHEMBL | |||||
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 5.92 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 7.30 | CHEMBL | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 5.67 | DRUG MATRIX | |||||
D(2) dopamine receptor | GPCR | Ki | 4.89 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 7.05 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Kd | 9.01 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Kd | 9.05 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 8.52 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | IC50 | 7.77 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Kd | 8.76 | CHEMBL | |||||
Adrenergic receptor beta | GPCR | Ki | 8.62 | CHEMBL | |||||
Beta-3 adrenergic receptor | GPCR | ANTAGONIST | Ki | 6.60 | IUPHAR | ||||
Beta-1 adrenergic receptor | GPCR | Ki | 8.62 | CHEMBL |
ID | Source |
---|---|
4019916 | VUID |
N0000148001 | NUI |
D00483 | KEGG_DRUG |
318-98-9 | SECONDARY_CAS_RN |
4017831 | VANDF |
4019916 | VANDF |
C0033497 | UMLSCUI |
CHEBI:8499 | CHEBI |
CHEMBL27 | ChEMBL_ID |
DB00571 | DRUGBANK_ID |
CHEMBL1671 | ChEMBL_ID |
D011433 | MESH_DESCRIPTOR_UI |
4946 | PUBCHEM_CID |
564 | IUPHAR_LIGAND_ID |
1940 | INN_ID |
9Y8NXQ24VQ | UNII |
82084 | RXNORM |
2240 | MMSL |
5375 | MMSL |
d00032 | MMSL |
001850 | NDDF |
004740 | NDDF |
372772003 | SNOMEDCT_US |
55745002 | SNOMEDCT_US |
65088001 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3727 | SOLUTION | 20 mg | ORAL | ANDA | 11 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3727 | SOLUTION | 20 mg | ORAL | ANDA | 11 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3730 | SOLUTION | 40 mg | ORAL | ANDA | 11 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-3730 | SOLUTION | 40 mg | ORAL | ANDA | 11 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1659 | TABLET | 10 mg | ORAL | ANDA | 21 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1660 | TABLET | 20 mg | ORAL | ANDA | 21 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1661 | TABLET | 40 mg | ORAL | ANDA | 21 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1662 | TABLET | 80 mg | ORAL | ANDA | 21 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1693 | TABLET | 60 mg | ORAL | ANDA | 19 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0908 | SOLUTION | 20 mg | ORAL | ANDA | 11 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0908 | SOLUTION | 20 mg | ORAL | ANDA | 11 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9872 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9872 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2778 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 20 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2779 | CAPSULE, EXTENDED RELEASE | 80 mg | ORAL | ANDA | 20 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2780 | CAPSULE, EXTENDED RELEASE | 120 mg | ORAL | ANDA | 20 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0228-2781 | CAPSULE, EXTENDED RELEASE | 160 mg | ORAL | ANDA | 20 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0182 | TABLET | 10 mg | ORAL | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0182 | TABLET | 10 mg | ORAL | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0183 | TABLET | 20 mg | ORAL | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0183 | TABLET | 20 mg | ORAL | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0184 | TABLET | 40 mg | ORAL | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0184 | TABLET | 40 mg | ORAL | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0185 | TABLET | 80 mg | ORAL | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0185 | TABLET | 80 mg | ORAL | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0187 | TABLET | 60 mg | ORAL | ANDA | 23 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0187 | TABLET | 60 mg | ORAL | ANDA | 23 sections |
PROPRANOLOL HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9944 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 12 sections |
PROPRANOLOL HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9944 | INJECTION | 1 mg | INTRAVENOUS | ANDA | 12 sections |
Propranolol Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-4116 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 23 sections |