timolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 4061 26839-75-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • timolol
  • timolol maleate
  • (-)-Timolol
  • (S)-Timolol
  • arutimol
  • L-Timolol
  • timolol maleate salt
A beta-adrenergic antagonist that is similar in action to PROPRANOLOL; the levo-isomer is more active. Timolol has been proposed as an anti-hypertensive, anti-arrhythmic, anti-angina, and anti-glaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
  • Molecular weight: 316.42
  • Formula: C13H24N4O3S
  • CLOGP: 1.78
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 79.74
  • ALOGS: -3.07
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.74 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 15 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 3.16 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 61 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.90 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.20 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.431 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.738 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 4.819 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 7.568 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 83.900 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 74.870 % High 1
herg hERG pIC50 4.552 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 3.214 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.459 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 78.680 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP3K21,MAPK7,NTRK2,PDK2,PDK4,PIK3CA,PRKDC,SIK2,TEK 21
kinase-selectivity-class BRAF 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.742 High 1
mh-clint Mouse hepatocyte intrinsic clearance 61.094 High 1
mppb Mouse plasma protein binding (% unbound) 81.470 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 3.273 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 85.110 % High 1
rh-clint Rat hepatocyte intrinsic clearance 61.660 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.460 % High 1
rppb Rat plasma protein binding (% unbound) 80.870 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 922.571 uM High 1

Approvals:

DateAgencyCompanyOrphan
March 25, 2020 PMDA Senju Pharmaceutical Co., Ltd
Aug. 17, 1978 FDA ATON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Treatment failure 578.16 13.65 503 19687 303425 90304832
Eye irritation 509.78 13.65 214 19976 33764 90574493
Intraocular pressure increased 476.39 13.65 137 20053 6956 90601301
Eye pain 362.51 13.65 183 20007 43985 90564272
Ocular hyperaemia 312.82 13.65 152 20038 33646 90574611
Glaucoma 218.42 13.65 102 20088 20653 90587604
Vision blurred 162.93 13.65 159 20031 110134 90498123
Eye pruritus 145.76 13.65 87 20103 28940 90579317
Visual acuity reduced 143.79 13.65 80 20110 23330 90584927
Bradycardia 120.28 13.65 119 20071 83728 90524529
Lacrimation increased 117.70 13.65 74 20116 26988 90581269
Product container issue 98.34 13.65 31 20159 2150 90606107
Choroidal effusion 94.19 13.65 24 20166 765 90607492
Corneal oedema 94.01 13.65 29 20161 1872 90606385
Foreign body sensation in eyes 78.33 13.65 29 20161 3271 90604986
Product delivery mechanism issue 73.09 13.65 18 20172 498 90607759
Frustration tolerance decreased 71.46 13.65 35 20155 7861 90600396
Cataract 69.50 13.65 83 20107 72009 90536248
Product quality issue 66.29 13.65 85 20105 79240 90529017
Iris adhesions 66.10 13.65 16 20174 411 90607846
Ulcerative keratitis 62.81 13.65 25 20165 3428 90604829
Eyelid margin crusting 58.91 13.65 20 20170 1752 90606505
Conjunctival hyperaemia 57.84 13.65 23 20167 3146 90605111
Corneal deposits 57.61 13.65 14 20176 366 90607891
Systemic lupus erythematosus 56.65 13.65 7 20183 361889 90246368
Forced expiratory volume decreased 56.34 13.65 27 20163 5781 90602476
Choroidal detachment 56.07 13.65 13 20177 276 90607981
Trabeculectomy 54.22 13.65 9 20181 27 90608230
Total lung capacity increased 53.80 13.65 25 20165 4996 90603261
Hypotony of eye 53.63 13.65 12 20178 216 90608041
Pulmonary thrombosis 53.51 13.65 31 20159 9751 90598506
Glossodynia 53.48 13.65 5 20185 321774 90286483
Eye discharge 52.83 13.65 29 20161 8229 90600028
Synovitis 52.54 13.65 6 20184 329746 90278511
Corneal disorder 52.37 13.65 19 20171 2023 90606234
Visual impairment 51.73 13.65 100 20090 132265 90475992
Retinal disorder 49.76 13.65 18 20172 1901 90606356
Product packaging quantity issue 49.04 13.65 17 20173 1585 90606672
Eye inflammation 48.66 13.65 27 20163 7824 90600433
Respiration abnormal 48.30 13.65 27 20163 7936 90600321
Cystoid macular oedema 48.18 13.65 18 20172 2082 90606175
Iridocyclitis 48.04 13.65 21 20169 3640 90604617
Wound 47.07 13.65 6 20184 302974 90305283
Angle closure glaucoma 46.71 13.65 19 20171 2756 90605501
Peak expiratory flow rate decreased 45.77 13.65 13 20177 629 90607628
Vitamin B12 decreased 43.50 13.65 22 20168 5288 90602969
Lung diffusion test decreased 42.46 13.65 13 20177 818 90607439
Abdominal discomfort 41.13 13.65 28 20162 477300 90130957
Eye swelling 40.80 13.65 41 20149 29345 90578912
Infusion related reaction 40.76 13.65 21 20169 416759 90191498
Erythema of eyelid 40.40 13.65 18 20172 3265 90604992
Macular oedema 39.23 13.65 20 20170 4889 90603368
Punctate keratitis 38.76 13.65 12 20178 784 90607473
Blindness 38.60 13.65 38 20152 26530 90581727
Intraocular pressure test abnormal 37.65 13.65 9 20181 219 90608038
Growth of eyelashes 37.42 13.65 9 20181 225 90608032
Eosinophilic cellulitis 37.30 13.65 9 20181 228 90608029
Endophthalmitis 37.18 13.65 19 20171 4666 90603591
Hepatic enzyme increased 37.06 13.65 17 20173 360719 90247538
Ocular discomfort 37.01 13.65 21 20169 6349 90601908
Psoriatic arthropathy 36.75 13.65 4 20186 228331 90379926
Atrioventricular block complete 35.71 13.65 24 20166 9787 90598470
Abnormal sensation in eye 34.91 13.65 14 20176 1957 90606300
Visual field defect 34.72 13.65 21 20169 7145 90601112
Thermal burns of eye 34.68 13.65 8 20182 166 90608091
Fall 34.57 13.65 204 19986 481606 90126651
Vitreous haemorrhage 34.25 13.65 15 20175 2611 90605646
Procollagen type I C-terminal propeptide increased 34.24 13.65 6 20184 27 90608230
Forced vital capacity decreased 34.14 13.65 12 20178 1166 90607091
Serum procollagen type I N-terminal propeptide increased 34.06 13.65 6 20184 28 90608229
Incorrect dose administered 33.76 13.65 62 20128 78868 90529389
Maternal exposure during pregnancy 32.53 13.65 20 20170 360043 90248214
Syncope 32.33 13.65 83 20107 132580 90475677
Conjunctival ulcer 31.75 13.65 6 20184 44 90608213
Keratopathy 31.66 13.65 10 20180 698 90607559
Conjunctival scar 30.86 13.65 6 20184 52 90608205
Flat anterior chamber of eye 30.66 13.65 6 20184 54 90608203
Swelling 30.56 13.65 29 20161 419029 90189228
Eye disorder 30.53 13.65 34 20156 27356 90580901
Haemangioma congenital 29.70 13.65 9 20181 547 90607710
Type 2 diabetes mellitus 29.30 13.65 5 20185 203239 90405018
Corneal degeneration 28.99 13.65 7 20183 178 90608079
Dizziness 28.82 13.65 227 19963 589057 90019200
Obstructive airways disorder 28.64 13.65 32 20158 25837 90582420
Corneal endothelial cell loss 28.44 13.65 5 20185 23 90608234
Glaucoma surgery 28.43 13.65 6 20184 81 90608176
Blindness unilateral 28.33 13.65 19 20171 7717 90600540
Hallucination, visual 28.06 13.65 30 20160 23062 90585195
Dry eye 27.99 13.65 48 20142 57883 90550374
Superficial injury of eye 27.95 13.65 8 20182 398 90607859
Chronotropic incompetence 27.72 13.65 6 20184 92 90608165
Vertigo 27.57 13.65 53 20137 69758 90538499
Liquid product physical issue 27.42 13.65 11 20179 1539 90606718
Uveitis 27.40 13.65 25 20165 15878 90592379
Arthropathy 27.10 13.65 25 20165 366217 90242040
Toxic anterior segment syndrome 26.61 13.65 12 20178 2238 90606019
Corneal epithelium defect 26.45 13.65 8 20182 483 90607774
Conjunctivitis 26.14 13.65 31 20159 26675 90581582
Hand deformity 26.02 13.65 17 20173 296345 90311912
Contraindicated product administered 25.96 13.65 20 20170 320119 90288138
Product dose omission issue 25.93 13.65 131 20059 291556 90316701
Fibromyalgia 25.82 13.65 7 20183 206262 90401995
Retinal detachment 25.58 13.65 17 20173 6805 90601452
Hypopyon 25.30 13.65 9 20181 905 90607352
Liver injury 25.02 13.65 4 20186 170563 90437694
Lethargy 25.01 13.65 48 20142 63091 90545166
Keratitis interstitial 24.93 13.65 4 20186 9 90608248
Iris neovascularisation 24.81 13.65 5 20185 53 90608204
Sinoatrial block 24.47 13.65 9 20181 996 90607261
Achromotrichia acquired 24.35 13.65 4 20186 11 90608246
Irritable bowel syndrome 24.22 13.65 8 20182 207440 90400817
Vitreous floaters 24.02 13.65 17 20173 7532 90600725
Iritis 23.73 13.65 13 20177 3673 90604584
Foreign body in eye 23.71 13.65 6 20184 186 90608071
Pain 23.17 13.65 129 20061 996212 89612045
Blepharitis 22.81 13.65 13 20177 3963 90604294
Hypotension 22.80 13.65 137 20053 325260 90282997
Nasopharyngitis 22.45 13.65 35 20155 407069 90201188
Discomfort 22.41 13.65 17 20173 274318 90333939
Corneal thickening 22.16 13.65 4 20186 22 90608235
Ectropion 22.02 13.65 6 20184 249 90608008
Conjunctivitis allergic 22.01 13.65 9 20181 1323 90606934
Eyelids pruritus 21.73 13.65 10 20180 1954 90606303
Corneal opacity 21.60 13.65 8 20182 903 90607354
Drug intolerance 21.48 13.65 42 20148 447549 90160708
Product substitution issue 21.19 13.65 23 20167 17985 90590272
Intentional product use issue 21.07 13.65 11 20179 216881 90391376
Joint swelling 21.04 13.65 51 20139 503249 90105008
Vitreal cells 21.02 13.65 5 20185 119 90608138
Open angle glaucoma 20.86 13.65 6 20184 304 90607953
Anterior chamber fibrin 20.56 13.65 5 20185 131 90608126
Sinus bradycardia 20.55 13.65 22 20168 16930 90591327
Atrial fibrillation 20.53 13.65 71 20119 133540 90474717
Therapeutic product effect decreased 20.46 13.65 19 20171 277552 90330705
Joint range of motion decreased 20.31 13.65 3 20187 135640 90472617
Hypothermia 20.29 13.65 21 20169 15554 90592703
Hypercatabolism 20.15 13.65 3 20187 3 90608254
Oculocardiac reflex 20.15 13.65 3 20187 3 90608254
Genital erythema 20.15 13.65 4 20186 39 90608218
General physical health deterioration 20.08 13.65 30 20160 355085 90253172
Retinal degeneration 20.07 13.65 8 20182 1101 90607156
Stomatitis 20.02 13.65 19 20171 274679 90333578
Completed suicide 19.98 13.65 4 20186 145054 90463203
Corneal transplant 19.92 13.65 6 20184 357 90607900
Musculoskeletal stiffness 19.92 13.65 22 20168 296510 90311747
Impaired healing 19.79 13.65 14 20176 234185 90374072
Photophobia 19.69 13.65 24 20166 21245 90587012
Sinonasal papilloma 19.63 13.65 4 20186 45 90608212
Gastrointestinal disorder 19.60 13.65 17 20173 256670 90351587
Weight increased 19.38 13.65 40 20150 417887 90190370
Nodal rhythm 19.32 13.65 9 20181 1809 90606448
Blood pressure systolic increased 19.12 13.65 41 20149 58304 90549953
Haematemesis 19.06 13.65 30 20160 33696 90574561
Blindness transient 18.69 13.65 12 20178 4531 90603726
Ill-defined disorder 18.53 13.65 9 20181 184882 90423375
Corneal decompensation 18.50 13.65 4 20186 61 90608196
Hypotonia 17.83 13.65 17 20173 11409 90596848
Intraocular pressure fluctuation 17.83 13.65 4 20186 73 90608184
Myocardial infarction 17.77 13.65 58 20132 105914 90502343
Eyelid oedema 17.70 13.65 17 20173 11517 90596740
Product physical consistency issue 17.68 13.65 7 20183 947 90607310
Small for dates baby 17.63 13.65 12 20178 4995 90603262
Haemangioma 17.60 13.65 10 20180 3032 90605225
Arthralgia 17.42 13.65 102 20088 778420 89829837
Optic nerve cupping 17.40 13.65 3 20187 12 90608245
Eyelid irritation 17.30 13.65 7 20183 1001 90607256
Myalgia 17.23 13.65 81 20109 175044 90433213
Product administration error 17.05 13.65 25 20165 26398 90581859
Conjunctival follicles 17.03 13.65 3 20187 14 90608243
Short stature 16.90 13.65 7 20183 1063 90607194
Pyrexia 16.72 13.65 83 20107 660402 89947855
Product use issue 16.66 13.65 30 20160 329889 90278368
Rheumatoid arthritis 16.56 13.65 35 20155 362579 90245678
Ocular pemphigoid 16.52 13.65 4 20186 103 90608154
Conjunctival disorder 16.45 13.65 5 20185 307 90607950
Hyponatraemia 16.37 13.65 66 20124 133472 90474785
Intraocular pressure decreased 15.96 13.65 4 20186 119 90608138
Anterior chamber cell 15.76 13.65 6 20184 730 90607527
Eye oedema 15.73 13.65 8 20182 1944 90606313
Blood cholesterol increased 15.61 13.65 14 20176 207998 90400259
Eye allergy 15.51 13.65 7 20183 1308 90606949
Eyelid pain 15.40 13.65 6 20184 777 90607480
Intraocular lens implant 15.34 13.65 5 20185 386 90607871
Arrhythmia 15.33 13.65 31 20159 42301 90565956
Urticaria 15.29 13.65 29 20161 312705 90295552
Migraine 15.29 13.65 12 20178 190380 90417877
Bronchopulmonary disease 15.23 13.65 3 20187 28 90608229
Stag horn calculus 15.20 13.65 4 20186 145 90608112
Depressed mood 14.99 13.65 34 20156 50188 90558069
Blister 14.94 13.65 21 20169 254977 90353280
Eyelid disorder 14.82 13.65 8 20182 2195 90606062
Conjunctival erosion 14.82 13.65 4 20186 160 90608097
Retinal vascular occlusion 14.75 13.65 5 20185 436 90607821
Herpes ophthalmic 14.66 13.65 7 20183 1487 90606770
Exposure during pregnancy 14.61 13.65 19 20171 238391 90369866
Wound infection 14.51 13.65 3 20187 106399 90501858
Swelling of eyelid 14.45 13.65 11 20179 5443 90602814
Peripheral swelling 14.18 13.65 46 20144 413060 90195197
Pulse pressure decreased 14.07 13.65 4 20186 194 90608063
Injury 13.97 13.65 14 20176 197335 90410922
Retinal haemorrhage 13.91 13.65 11 20179 5753 90602504
Ocular hypertension 13.88 13.65 7 20183 1673 90606584
Product complaint 13.76 13.65 16 20174 13484 90594773

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Treatment failure 704.92 14.78 357 12908 62267 42545803
Intraocular pressure increased 377.83 14.78 121 13144 6312 42601758
Eye irritation 265.62 14.78 108 13157 11210 42596860
Eye pain 181.90 14.78 94 13171 16936 42591134
Visual acuity reduced 167.91 14.78 90 13175 17460 42590610
Ocular hyperaemia 144.72 14.78 79 13186 15884 42592186
Vision blurred 120.03 14.78 113 13152 53586 42554484
Glaucoma 107.10 14.78 52 13213 8196 42599874
Corneal oedema 90.34 14.78 29 13236 1519 42606551
Bradycardia 81.72 14.78 116 13149 85368 42522702
Corneal deposits 80.81 14.78 18 13247 222 42607848
Lacrimation increased 69.14 14.78 44 13221 11714 42596356
Product quality issue 67.62 14.78 51 13214 17831 42590239
Product delivery mechanism issue 63.08 14.78 15 13250 251 42607819
Intraocular pressure test abnormal 57.61 14.78 12 13253 105 42607965
Product container issue 56.95 14.78 18 13247 896 42607174
Blindness 52.39 14.78 44 13221 17934 42590136
Cataract 49.29 14.78 54 13211 30550 42577520
Anterior chamber disorder 49.26 14.78 10 13255 76 42607994
Hyphaema 48.29 14.78 15 13250 705 42607365
Eye pruritus 46.39 14.78 34 13231 11378 42596692
Toxic anterior segment syndrome 45.55 14.78 17 13248 1399 42606671
Choroidal detachment 43.70 14.78 13 13252 527 42607543
Visual impairment 41.87 14.78 59 13206 43054 42565016
Iridocyclitis 41.45 14.78 18 13247 2193 42605877
Floppy iris syndrome 40.72 14.78 11 13254 313 42607757
Infectious crystalline keratopathy 39.62 14.78 8 13257 59 42608011
Hypotony of eye 38.29 14.78 10 13255 249 42607821
Eye discharge 36.24 14.78 18 13247 2977 42605093
Ocular discomfort 35.89 14.78 18 13247 3039 42605031
Corneal disorder 35.11 14.78 13 13252 1046 42607024
Foreign body sensation in eyes 32.68 14.78 12 13253 943 42607127
Blindness unilateral 31.27 14.78 20 13245 5368 42602702
Intraocular pressure decreased 31.16 14.78 7 13258 90 42607980
Erythema of eyelid 30.70 14.78 13 13252 1490 42606580
Anterior chamber inflammation 29.57 14.78 9 13256 395 42607675
Dry eye 27.85 14.78 29 13236 15477 42592593
Abnormal sensation in eye 27.42 14.78 10 13255 771 42607299
Scleral hyperaemia 27.40 14.78 6 13259 68 42608002
Ocular hypertension 27.13 14.78 11 13254 1130 42606940
Ulcerative keratitis 26.60 14.78 13 13252 2075 42605995
Corneal infection 26.60 14.78 5 13260 24 42608046
Eye swelling 26.42 14.78 25 13240 11895 42596175
Visual acuity tests abnormal 25.78 14.78 6 13259 91 42607979
Cystoid macular oedema 24.70 14.78 10 13255 1023 42607047
Eye inflammation 23.93 14.78 14 13251 3204 42604866
Choroidal effusion 23.84 14.78 7 13258 271 42607799
Administration site discomfort 23.59 14.78 5 13260 48 42608022
Eyelid oedema 23.22 14.78 17 13248 5678 42602392
Dizziness 22.82 14.78 144 13121 249110 42358960
Eye infection 22.40 14.78 15 13250 4346 42603724
Conjunctival oedema 21.73 14.78 8 13257 633 42607437
Uveitis 21.64 14.78 20 13245 9238 42598832
Conjunctival hyperaemia 21.49 14.78 13 13252 3163 42604907
Macular degeneration 21.43 14.78 12 13253 2529 42605541
Retinal detachment 21.16 14.78 17 13248 6508 42601562
Intraocular pressure fluctuation 21.14 14.78 4 13261 20 42608050
Growth of eyelashes 20.68 14.78 5 13260 90 42607980
Atrioventricular block second degree 20.55 14.78 14 13251 4173 42603897
Off label use 20.52 14.78 116 13149 638219 41969851
Completed suicide 20.14 14.78 3 13262 96462 42511608
Photophobia 19.88 14.78 18 13247 8101 42599969
Trabeculectomy 19.87 14.78 4 13261 29 42608041
Eye disorder 19.58 14.78 21 13244 11591 42596479
Iris adhesions 19.50 14.78 6 13259 273 42607797
Scleral disorder 19.10 14.78 4 13261 36 42608034
Macular scar 19.00 14.78 4 13261 37 42608033
Product packaging quantity issue 18.98 14.78 9 13256 1344 42606726
Conjunctival scar 18.96 14.78 6 13259 300 42607770
Eye haemorrhage 18.75 14.78 14 13251 4816 42603254
Corneal degeneration 18.63 14.78 4 13261 41 42608029
Visual field defect 18.47 14.78 14 13251 4924 42603146
Hypotony maculopathy 17.83 14.78 4 13261 51 42608019
Angle closure glaucoma 17.40 14.78 8 13257 1114 42606956
Eyelid irritation 17.35 14.78 6 13259 396 42607674
Atrioventricular block 17.30 14.78 18 13247 9597 42598473
Optic nerve cupping 17.11 14.78 4 13261 62 42608008
Corneal epithelium defect 17.06 14.78 6 13259 416 42607654
Product packaging issue 16.85 14.78 7 13258 764 42607306
Punctate keratitis 16.81 14.78 6 13259 435 42607635
Cataract nuclear 16.63 14.78 7 13258 790 42607280
Vertebral end plate inflammation 16.61 14.78 5 13260 211 42607859
Funguria 16.44 14.78 4 13261 74 42607996
Cardiovascular insufficiency 16.43 14.78 9 13256 1817 42606253
Glaucoma surgery 16.03 14.78 3 13262 14 42608056
Blepharitis 15.95 14.78 9 13256 1924 42606146
Dermatitis 15.81 14.78 19 13246 11856 42596214
Hypersensitivity 15.78 14.78 54 13211 72316 42535754
Coronavirus infection 15.68 14.78 13 13252 5201 42602869
Vitreous haemorrhage 15.45 14.78 10 13255 2737 42605333
Endophthalmitis 15.34 14.78 12 13253 4421 42603649
Electrolyte depletion 15.25 14.78 5 13260 280 42607790
Choroidal haemorrhage 15.04 14.78 4 13261 107 42607963
Cutis laxa 14.83 14.78 4 13261 113 42607957
Eyelid margin crusting 14.82 14.78 6 13259 614 42607456

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intraocular pressure increased 617.24 12.36 186 25440 10690 110552983
Eye irritation 353.95 12.36 167 25459 33285 110530388
Eye pain 295.70 12.36 169 25457 49930 110513743
Visual acuity reduced 243.66 12.36 128 25498 32045 110531628
Ocular hyperaemia 233.07 12.36 133 25493 39153 110524520
Glaucoma 197.75 12.36 99 25527 22418 110541255
Bradycardia 196.77 12.36 210 25416 155307 110408366
Vision blurred 182.55 12.36 185 25441 128837 110434836
Corneal oedema 149.19 12.36 47 25579 3126 110560547
Lacrimation increased 147.51 12.36 91 25535 30859 110532814
Eye pruritus 118.43 12.36 81 25545 32694 110530979
Choroidal detachment 98.69 12.36 25 25601 747 110562926
Corneal deposits 94.80 12.36 23 25603 573 110563100
Choroidal effusion 90.38 12.36 24 25602 866 110562807
Iris adhesions 82.56 12.36 21 25605 638 110563035
Corneal disorder 80.14 12.36 28 25598 2569 110561104
Cataract 72.90 12.36 91 25535 79394 110484279
Eye discharge 69.60 12.36 36 25590 8718 110554955
Hypotony of eye 68.79 12.36 17 25609 458 110563215
Ulcerative keratitis 66.89 12.36 29 25597 4737 110558936
Iridocyclitis 66.54 12.36 30 25596 5378 110558295
Toxic anterior segment syndrome 65.31 12.36 26 25600 3428 110560245
Intraocular pressure test abnormal 64.61 12.36 14 25612 207 110563466
Conjunctival hyperaemia 64.37 12.36 30 25596 5801 110557872
Trabeculectomy 61.38 12.36 11 25615 55 110563618
Floppy iris syndrome 58.04 12.36 14 25612 340 110563333
Cystoid macular oedema 56.18 12.36 22 25604 2778 110560895
Angle closure glaucoma 54.76 12.36 23 25603 3476 110560197
Eye inflammation 54.23 12.36 31 25595 9140 110554533
Frustration tolerance decreased 52.93 12.36 30 25596 8701 110554972
Total lung capacity increased 52.43 12.36 25 25601 5087 110558586
Visual field defect 51.53 12.36 31 25595 10041 110553632
Blindness 51.10 12.36 52 25574 36307 110527366
Anterior chamber disorder 50.93 12.36 11 25615 160 110563513
Hyphaema 50.39 12.36 16 25610 1091 110562582
Uveitis 50.08 12.36 41 25585 21669 110542004
Endophthalmitis 49.28 12.36 28 25598 8159 110555514
Vitreous haemorrhage 48.63 12.36 23 25603 4597 110559076
Synovitis 45.87 12.36 5 25621 274087 110289586
Vitamin B12 decreased 45.81 12.36 23 25603 5234 110558439
Systemic lupus erythematosus 44.23 12.36 4 25622 254334 110309339
Peak expiratory flow rate decreased 44.16 12.36 13 25613 687 110562986
Dizziness 43.14 12.36 293 25333 697900 109865773
Conjunctival scar 43.03 12.36 11 25615 341 110563332
Ocular discomfort 42.97 12.36 26 25600 8507 110555166
Fall 42.63 12.36 262 25364 603220 109960453
Foreign body sensation in eyes 42.63 12.36 19 25607 3315 110560358
Pulmonary thrombosis 42.50 12.36 31 25595 13832 110549841
Corneal epithelium defect 40.77 12.36 13 25613 899 110562774
Infectious crystalline keratopathy 39.89 12.36 8 25618 79 110563594
Erythema of eyelid 39.71 12.36 19 25607 3896 110559777
Respiration abnormal 39.65 12.36 26 25600 9783 110553890
Retinal detachment 39.06 12.36 27 25599 11073 110552600
Punctate keratitis 37.22 12.36 13 25613 1191 110562482
Corneal degeneration 36.69 12.36 9 25617 235 110563438
Ocular hypertension 34.93 12.36 15 25611 2393 110561280
Forced expiratory volume decreased 34.92 12.36 27 25599 13149 110550524
Completed suicide 34.64 12.36 7 25619 242374 110321299
Eosinophilic cellulitis 34.58 12.36 9 25617 300 110563373
Infusion related reaction 34.46 12.36 23 25603 381139 110182534
Atrioventricular block complete 34.37 12.36 32 25594 20050 110543623
Blepharitis 34.13 12.36 18 25608 4534 110559139
Ectropion 34.12 12.36 10 25616 520 110563153
Sinus bradycardia 34.06 12.36 38 25588 29445 110534228
Hepatic enzyme increased 33.84 12.36 16 25610 320876 110242797
Serum procollagen type I N-terminal propeptide increased 33.65 12.36 6 25620 29 110563644
Visual impairment 33.57 12.36 87 25539 134341 110429332
Procollagen type I C-terminal propeptide increased 33.31 12.36 6 25620 31 110563642
Maternal exposure during pregnancy 33.18 12.36 9 25617 254874 110308799
Lung diffusion test decreased 33.11 12.36 13 25613 1652 110562021
Atrioventricular block 33.03 12.36 29 25597 16848 110546825
Intraocular pressure fluctuation 33.00 12.36 7 25619 93 110563580
Blindness unilateral 32.56 12.36 23 25603 9763 110553910
Vertigo 32.54 12.36 66 25560 86804 110476869
Eye disorder 31.26 12.36 36 25590 28870 110534803
Forced vital capacity decreased 31.00 12.36 13 25613 1957 110561716
Iritis 30.97 12.36 17 25609 4635 110559038
Syncope 30.71 12.36 110 25516 202426 110361247
Glossodynia 30.52 12.36 7 25619 221997 110341676
Anterior chamber inflammation 30.38 12.36 10 25616 765 110562908
Duodenal ulcer perforation 30.35 12.36 3 25623 177697 110385976
Corneal endothelial cell loss 30.18 12.36 5 25621 14 110563659
Flat anterior chamber of eye 29.26 12.36 7 25619 164 110563509
Instillation site irritation 29.18 12.36 7 25619 166 110563507
Product substitution issue 28.86 12.36 31 25595 23030 110540643
Retinal disorder 28.69 12.36 13 25613 2357 110561316
Keratopathy 28.30 12.36 11 25615 1362 110562311
Corneal decompensation 27.99 12.36 6 25620 84 110563589
Eyelid margin crusting 27.42 12.36 12 25614 2004 110561669
Nodal rhythm 26.99 12.36 14 25612 3409 110560264
Abdominal discomfort 26.86 12.36 31 25595 393827 110169846
Product container issue 26.80 12.36 11 25615 1569 110562104
Product delivery mechanism issue 26.59 12.36 7 25619 244 110563429
Abnormal sensation in eye 26.49 12.36 12 25614 2174 110561499
Corneal infection 26.37 12.36 6 25620 112 110563561
Chronotropic incompetence 25.94 12.36 6 25620 121 110563552
Wound 25.79 12.36 11 25615 234426 110329247
Atrioventricular block second degree 24.42 12.36 18 25608 8163 110555510
Photophobia 24.41 12.36 30 25596 25741 110537932
Hyperkalaemia 24.32 12.36 78 25548 135718 110427955
Fibromyalgia 24.28 12.36 5 25621 170904 110392769
Dry eye 24.07 12.36 45 25581 55748 110507925
Visual acuity tests abnormal 23.89 12.36 6 25620 173 110563500
Conjunctivitis 23.77 12.36 34 25592 33758 110529915
Vitreal cells 23.72 12.36 6 25620 178 110563495
Impaired healing 23.69 12.36 8 25618 196709 110366964
Drug intolerance 23.64 12.36 36 25590 406476 110157197
Conjunctival oedema 23.59 12.36 10 25616 1546 110562127
Intraocular pressure decreased 23.50 12.36 6 25620 185 110563488
Growth of eyelashes 23.32 12.36 6 25620 191 110563482
Iris transillumination defect 23.02 12.36 6 25620 201 110563472
Optic nerve cupping 22.94 12.36 5 25621 76 110563597
Irritable bowel syndrome 22.93 12.36 5 25621 164210 110399463
Hand deformity 22.87 12.36 11 25615 218495 110345178
Hypotension 22.39 12.36 202 25424 523647 110040026
Macular oedema 22.32 12.36 16 25610 6950 110556723
Corneal opacity 22.21 12.36 9 25617 1242 110562431
Conjunctival follicles 22.16 12.36 4 25622 21 110563652
Cataract subcapsular 22.14 12.36 9 25617 1252 110562421
Psoriatic arthropathy 22.02 12.36 9 25617 196752 110366921
Hyponatraemia 21.76 12.36 104 25522 217549 110346124
Subretinal fluid 21.59 12.36 9 25617 1335 110562338
Achromotrichia acquired 21.56 12.36 4 25622 25 110563648
Product complaint 21.51 12.36 21 25605 13951 110549722
Swelling 21.47 12.36 30 25596 351011 110212662
Glaucoma surgery 21.42 12.36 5 25621 105 110563568
Corneal thickening 21.30 12.36 4 25622 27 110563646
Hypopyon 20.99 12.36 9 25617 1431 110562242
Sinoatrial block 20.84 12.36 9 25617 1456 110562217
Abdominal pain 20.80 12.36 56 25570 512933 110050740
Hypotony maculopathy 20.59 12.36 4 25622 33 110563640
Vitreous floaters 20.54 12.36 17 25609 9117 110554556
Arrhythmia 20.51 12.36 48 25578 69527 110494146
Arthropathy 20.29 12.36 22 25604 287500 110276173
Eye swelling 20.01 12.36 31 25595 33017 110530656
Retinal haemorrhage 19.95 12.36 17 25609 9484 110554189
Contraindicated product administered 19.84 12.36 17 25609 248250 110315423
Stomatitis 19.83 12.36 20 25606 270222 110293451
Loss of consciousness 19.76 12.36 94 25532 196212 110367461
Thermal burns of eye 19.62 12.36 5 25621 153 110563520
Sinonasal papilloma 19.55 12.36 4 25622 44 110563629
Hypotonia 19.41 12.36 21 25605 15724 110547949
Macular fibrosis 19.29 12.36 7 25619 717 110562956
Anterior chamber cell 19.02 12.36 8 25618 1213 110562460
Myocardial infarction 18.63 12.36 91 25535 191992 110371681
Intentional product use issue 18.59 12.36 18 25608 247888 110315785
C-reactive protein increased 18.56 12.36 14 25612 217905 110345768
Administration site discomfort 18.50 12.36 5 25621 193 110563480
Choroidal haemorrhage 18.48 12.36 5 25621 194 110563479
Vertebral end plate inflammation 18.07 12.36 5 25621 211 110563462
Hypercatabolism 17.49 12.36 3 25623 11 110563662
Anterior chamber fibrin 17.35 12.36 5 25621 245 110563428
Product quality issue 17.25 12.36 48 25578 77251 110486422
Hallucination, visual 17.16 12.36 32 25594 39573 110524100
Hallucination 17.02 12.36 57 25569 101375 110462298
Atrial fibrillation 16.98 12.36 101 25525 229541 110334132
Weight increased 16.86 12.36 46 25580 419598 110144075
Metamorphopsia 16.79 12.36 8 25618 1625 110562048
Corneal pigmentation 16.74 12.36 3 25623 15 110563658
Retinal degeneration 16.64 12.36 8 25618 1658 110562015
Liver injury 16.63 12.36 7 25619 150406 110413267
Eyelid oedema 16.49 12.36 19 25607 15243 110548430
Joint range of motion decreased 16.43 12.36 4 25622 121828 110441845
Heterochromia iridis 16.28 12.36 3 25623 18 110563655
Scleral hyperaemia 16.02 12.36 5 25621 322 110563351
Nasopharyngitis 16.01 12.36 43 25583 394318 110169355
Corneal scar 15.80 12.36 5 25621 337 110563336
Vitritis 15.77 12.36 9 25617 2644 110561029
Gastrointestinal haemorrhage 15.75 12.36 78 25548 165440 110398233
Orthostatic hypotension 15.64 12.36 42 25584 66207 110497466
Blindness transient 15.34 12.36 12 25614 5944 110557729
Dermatitis 15.33 12.36 25 25601 27812 110535861
Eyelid pain 15.28 12.36 6 25620 763 110562910
Rheumatoid arthritis 15.14 12.36 29 25597 299584 110264089
Deformity 15.14 12.36 15 25611 10145 110553528
Musculoskeletal stiffness 15.11 12.36 26 25600 279796 110283877
Eyelid ptosis 15.09 12.36 17 25609 13310 110550363
Conjunctival bleb 14.94 12.36 4 25622 149 110563524
Superficial injury of eye 14.91 12.36 5 25621 405 110563268
Pyrexia 14.80 12.36 135 25491 898130 109665543
Corneal transplant 14.76 12.36 5 25621 418 110563255
Keratitis interstitial 14.75 12.36 3 25623 32 110563641
Pain 14.68 12.36 146 25480 954809 109608864
Conjunctival disorder 14.66 12.36 5 25621 427 110563246
Type 2 diabetes mellitus 14.32 12.36 12 25614 177220 110386453
Lethargy 14.32 12.36 51 25575 93525 110470148
Stag horn calculus 14.32 12.36 4 25622 175 110563498
Rhinocerebral mucormycosis 14.29 12.36 7 25619 1510 110562163
Oversensing 14.28 12.36 3 25623 38 110563635
Blood pressure systolic increased 14.25 12.36 47 25579 82944 110480729
Product use issue 14.21 12.36 32 25594 311663 110252010
Chorioretinal disorder 14.14 12.36 4 25622 183 110563490
Symblepharon 14.02 12.36 5 25621 487 110563186
Cardiovascular insufficiency 13.99 12.36 9 25617 3279 110560394
Liquid product physical issue 13.94 12.36 7 25619 1593 110562080
Eyelid disorder 13.87 12.36 8 25618 2397 110561276
Therapeutic product effect incomplete 13.80 12.36 19 25607 223786 110339887
Electrolyte depletion 13.75 12.36 5 25621 515 110563158
Extrasystoles 13.74 12.36 13 25613 8305 110555368
Toxicity to various agents 13.69 12.36 61 25565 480494 110083179
Keratic precipitates 13.42 12.36 5 25621 551 110563122
Eye oedema 13.40 12.36 8 25618 2554 110561119
Arthralgia 13.35 12.36 116 25510 779516 109784157
Ocular pemphigoid 13.24 12.36 4 25622 231 110563442
Drug ineffective 13.12 12.36 452 25174 1520088 109043585
Scleral disorder 13.11 12.36 4 25622 239 110563434
Eye operation 13.11 12.36 8 25618 2659 110561014
Eyelid irritation 13.05 12.36 6 25620 1125 110562548
Alkalosis hypochloraemic 13.04 12.36 5 25621 596 110563077
Herpes ophthalmic 12.94 12.36 7 25619 1855 110561818
Bursitis 12.90 12.36 7 25619 129911 110433762
Retinal vascular occlusion 12.83 12.36 5 25621 623 110563050
Urticaria 12.77 12.36 35 25591 318822 110244851
Prostatic specific antigen increased 12.56 12.36 15 25611 12496 110551177
Corneal thinning 12.54 12.36 4 25622 277 110563396
Haematemesis 12.50 12.36 36 25590 59072 110504601
Keratitis 12.46 12.36 10 25616 5134 110558539
Instillation site erythema 12.43 12.36 3 25623 73 110563600
Bone formation increased 12.43 12.36 3 25623 73 110563600
Aortic valve incompetence 12.42 12.36 14 25612 10967 110552706

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AA06 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
ATC C07BA06 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, non-selective, and thiazides
ATC C07DA06 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, THIAZIDES AND OTHER DIURETICS
Beta blocking agents, non-selective, thiazides and other diuretics
ATC S01ED01 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Beta blocking agents
ATC S01ED51 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIGLAUCOMA PREPARATIONS AND MIOTICS
Beta blocking agents
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
CHEBI has role CHEBI:35530 beta-adrenergic blockers
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:39456 antiglaucoma agent

Related Drugs by ATC class:

C07AA Beta blocking agents, non-selective 13 drugs
alprenololbopindololbupranololcarteololcloranololmepindololnadololoxprenololpenbutololpindololpropranololsotalol show all 13 →
C07BA Beta blocking agents, non-selective, and thiazides 5 drugs
metipranololnadololoxprenololpropranololsotalol
S01ED Beta blocking agents 5 drugs
befunololbetaxololcarteolollevobunololmetipranolol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ocular hypertension indication 4210003 DOID:9282
Hypertensive disorder indication 38341003 DOID:10763
Open-angle glaucoma indication 84494001 DOID:1067
Myocardial Reinfarction Prevention indication
Migraine Prevention indication
Malignant glaucoma off-label use 10100008
Aphakic glaucoma off-label use 15374009
Secondary glaucoma off-label use 95717004
Angina pectoris off-label use 194828000
Angle-closure glaucoma off-label use 392291006 DOID:13550
Mitral valve prolapse off-label use 409712001
Stalled wound off-label use 789507005
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Acute cerebrovascular insufficiency contraindication 29322000
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Hyperuricemia contraindication 35885006 DOID:1920
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Sinus bradycardia contraindication 49710005
General anesthesia contraindication 50697003
Thromboangiitis obliterans contraindication 52403007 DOID:12918
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Cerebrovascular disease contraindication 62914000 DOID:6713
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Myasthenia gravis contraindication 91637004 DOID:437
Acute disease of cardiovascular system contraindication 128487001
Hypomagnesemia contraindication 190855004
Partial atrioventricular block contraindication 195039008
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Right ventricular failure contraindication 367363000
Azotemia contraindication 445009001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.15 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 9 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 9.70 WOMBAT-PK CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5.81 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 6.47 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 5.28 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.41 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.21 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 9.78 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 9.44 CHEMBL

External reference:

IDSource
4019949 VUID
N0000148034 NUI
D00378 KEGG_DRUG
91524-16-2 SECONDARY_CAS_RN
26921-17-5 SECONDARY_CAS_RN
4017930 VANDF
4019949 VANDF
C0040233 UMLSCUI
CHEBI:9599 CHEBI
TIM PDB_CHEM_ID
CHEMBL499 ChEMBL_ID
CHEMBL1200870 ChEMBL_ID
DB00373 DRUGBANK_ID
D013999 MESH_DESCRIPTOR_UI
33624 PUBCHEM_CID
565 IUPHAR_LIGAND_ID
817W3C6175 UNII
10600 RXNORM
24737 MMSL
5585 MMSL
6436 MMSL
d00139 MMSL
001856 NDDF
004741 NDDF
372880004 SNOMEDCT_US
75359005 SNOMEDCT_US
85591001 SNOMEDCT_US
817W3C6175 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
COMBIGAN HUMAN PRESCRIPTION DRUG LABEL 2 0023-9211 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 27 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0055 TABLET 5 mg ORAL ANDA 22 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0221 TABLET 10 mg ORAL ANDA 22 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0715 TABLET 20 mg ORAL ANDA 22 sections
Brimonidine Tartrate and Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 2 0781-7186 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 25 sections
Brimonidine Tartrate and Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 2 0832-1425 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 27 sections
DORZOLAMIDE HYDROCHLORIDE TIMOLOL MALETAE Human Prescription Drug Label 2 14445-405 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 24 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 16571-223 TABLET 5 mg ORAL ANDA 14 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 16571-224 TABLET 10 mg ORAL ANDA 14 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 16571-225 TABLET 20 mg ORAL ANDA 14 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 17478-189 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 25 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 17478-288 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 23 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 17478-289 SOLUTION/ DROPS 2.50 mg OPHTHALMIC ANDA 23 sections
COSOPT PF HUMAN PRESCRIPTION DRUG LABEL 2 17478-604 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 26 sections
COSOPT HUMAN PRESCRIPTION DRUG LABEL 2 17478-605 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 28 sections
Istalol HUMAN PRESCRIPTION DRUG LABEL 1 24208-004 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 24 sections
Dorzolamide Hydrochloride and Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 2 24208-486 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 25 sections
Timoptic in Ocudose HUMAN PRESCRIPTION DRUG LABEL 1 24208-498 SOLUTION 3.40 mg OPHTHALMIC NDA 12 sections
Timoptic in Ocudose HUMAN PRESCRIPTION DRUG LABEL 1 24208-499 SOLUTION 6.80 mg OPHTHALMIC NDA 12 sections
Timoptic HUMAN PRESCRIPTION DRUG LABEL 1 24208-812 SOLUTION 2.50 mg OPHTHALMIC NDA 24 sections
Timoptic HUMAN PRESCRIPTION DRUG LABEL 1 24208-813 SOLUTION 5 mg OPHTHALMIC NDA 24 sections
Timoptic-XE HUMAN PRESCRIPTION DRUG LABEL 1 24208-814 SOLUTION 2.50 mg OPHTHALMIC NDA 23 sections
Timoptic-XE HUMAN PRESCRIPTION DRUG LABEL 1 24208-816 SOLUTION 5 mg OPHTHALMIC NDA 23 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 25021-008 SOLUTION, GEL FORMING / DROPS 2.50 mg OPHTHALMIC ANDA 26 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 25021-009 SOLUTION, GEL FORMING / DROPS 5 mg OPHTHALMIC ANDA 26 sections
Dorzolamide Hydrochloride and Timolol Maleate ophthalmic Solution HUMAN PRESCRIPTION DRUG LABEL 2 42571-147 SOLUTION/ DROPS 6.80 mg OPHTHALMIC ANDA 24 sections
DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE HUMAN PRESCRIPTION DRUG LABEL 2 42571-382 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 25 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 42571-398 SOLUTION/ DROPS 6.80 mg OPHTHALMIC ANDA 19 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 42571-403 SOLUTION/ DROPS 2.50 mg OPHTHALMIC ANDA 20 sections
Timolol Maleate HUMAN PRESCRIPTION DRUG LABEL 1 42571-404 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 20 sections