Stem definition | Drug id | CAS RN |
---|---|---|
beta-adrenoreceptor antagonists | 4061 | 26839-75-8 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
20 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 2.74 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 15 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 3.16 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 61 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.50 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 8.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.90 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 17, 1978 | FDA | ATON | |
March 25, 2020 | PMDA | Senju Pharmaceutical Co., Ltd |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Treatment failure | 663.43 | 13.51 | 500 | 17079 | 198543 | 63272900 |
Eye irritation | 467.48 | 13.51 | 189 | 17390 | 21782 | 63449661 |
Intraocular pressure increased | 402.68 | 13.51 | 122 | 17457 | 5956 | 63465487 |
Ocular hyperaemia | 299.73 | 13.51 | 144 | 17435 | 25000 | 63446443 |
Eye pain | 273.07 | 13.51 | 149 | 17430 | 33705 | 63437738 |
Glaucoma | 174.30 | 13.51 | 91 | 17488 | 18814 | 63452629 |
Vision blurred | 133.15 | 13.51 | 145 | 17434 | 91779 | 63379664 |
Eye pruritus | 122.94 | 13.51 | 72 | 17507 | 18599 | 63452844 |
Visual acuity reduced | 122.60 | 13.51 | 76 | 17503 | 21750 | 63449693 |
Product quality issue | 99.08 | 13.51 | 81 | 17498 | 35784 | 63435659 |
Product container issue | 97.69 | 13.51 | 31 | 17548 | 1762 | 63469681 |
Bradycardia | 88.16 | 13.51 | 105 | 17474 | 73122 | 63398321 |
Lacrimation increased | 82.22 | 13.51 | 58 | 17521 | 20573 | 63450870 |
Choroidal effusion | 80.59 | 13.51 | 20 | 17559 | 456 | 63470987 |
Corneal oedema | 77.99 | 13.51 | 25 | 17554 | 1468 | 63469975 |
Foreign body sensation in eyes | 71.84 | 13.51 | 26 | 17553 | 2208 | 63469235 |
Product delivery mechanism issue | 69.92 | 13.51 | 17 | 17562 | 355 | 63471088 |
Total lung capacity increased | 67.30 | 13.51 | 25 | 17554 | 2285 | 63469158 |
Iris adhesions | 66.70 | 13.51 | 16 | 17563 | 315 | 63471128 |
Frustration tolerance decreased | 65.42 | 13.51 | 34 | 17545 | 6954 | 63464489 |
Eyelid margin crusting | 64.52 | 13.51 | 20 | 17559 | 1052 | 63470391 |
Eye discharge | 58.20 | 13.51 | 30 | 17549 | 6033 | 63465410 |
Cataract | 57.72 | 13.51 | 75 | 17504 | 56978 | 63414465 |
Ulcerative keratitis | 56.49 | 13.51 | 23 | 17556 | 2687 | 63468756 |
Choroidal detachment | 56.21 | 13.51 | 13 | 17566 | 217 | 63471226 |
Conjunctival hyperaemia | 55.86 | 13.51 | 22 | 17557 | 2357 | 63469086 |
Hypotony of eye | 55.57 | 13.51 | 12 | 17567 | 144 | 63471299 |
Forced expiratory volume decreased | 54.77 | 13.51 | 27 | 17552 | 4941 | 63466502 |
Trabeculectomy | 54.52 | 13.51 | 9 | 17570 | 19 | 63471424 |
Pulmonary thrombosis | 50.63 | 13.51 | 31 | 17548 | 8671 | 63462772 |
Corneal disorder | 50.54 | 13.51 | 19 | 17560 | 1795 | 63469648 |
Eye inflammation | 48.88 | 13.51 | 26 | 17553 | 5573 | 63465870 |
Corneal deposits | 47.84 | 13.51 | 12 | 17567 | 286 | 63471157 |
Visual impairment | 46.91 | 13.51 | 84 | 17495 | 84362 | 63387081 |
Respiration abnormal | 45.56 | 13.51 | 26 | 17553 | 6391 | 63465052 |
Iridocyclitis | 44.48 | 13.51 | 19 | 17560 | 2503 | 63468940 |
Product packaging quantity issue | 44.38 | 13.51 | 16 | 17563 | 1343 | 63470100 |
Peak expiratory flow rate decreased | 43.24 | 13.51 | 13 | 17566 | 616 | 63470827 |
Cystoid macular oedema | 42.08 | 13.51 | 16 | 17563 | 1559 | 63469884 |
Lung diffusion test decreased | 41.91 | 13.51 | 13 | 17566 | 685 | 63470758 |
Punctate keratitis | 39.12 | 13.51 | 12 | 17567 | 609 | 63470834 |
Intraocular pressure test abnormal | 38.28 | 13.51 | 9 | 17570 | 162 | 63471281 |
Retinal disorder | 37.49 | 13.51 | 15 | 17564 | 1675 | 63469768 |
Abdominal discomfort | 36.27 | 13.51 | 22 | 17557 | 320863 | 63150580 |
Systemic lupus erythematosus | 36.14 | 13.51 | 7 | 17572 | 208911 | 63262532 |
Ocular discomfort | 35.11 | 13.51 | 19 | 17560 | 4214 | 63467229 |
Thermal burns of eye | 33.62 | 13.51 | 8 | 17571 | 152 | 63471291 |
Abnormal sensation in eye | 33.59 | 13.51 | 14 | 17565 | 1735 | 63469708 |
Angle closure glaucoma | 33.55 | 13.51 | 15 | 17564 | 2204 | 63469239 |
Procollagen type I C-terminal propeptide increased | 33.50 | 13.51 | 6 | 17573 | 24 | 63471419 |
Eye swelling | 33.31 | 13.51 | 37 | 17542 | 23881 | 63447562 |
Glossodynia | 33.12 | 13.51 | 5 | 17574 | 178871 | 63292572 |
Synovitis | 32.89 | 13.51 | 6 | 17573 | 186912 | 63284531 |
Serum procollagen type I N-terminal propeptide increased | 32.75 | 13.51 | 6 | 17573 | 28 | 63471415 |
Forced vital capacity decreased | 32.62 | 13.51 | 12 | 17567 | 1067 | 63470376 |
Visual field defect | 32.23 | 13.51 | 21 | 17558 | 6540 | 63464903 |
Corneal degeneration | 32.12 | 13.51 | 7 | 17572 | 88 | 63471355 |
Pain | 31.44 | 13.51 | 103 | 17476 | 740525 | 62730918 |
Macular oedema | 31.04 | 13.51 | 17 | 17562 | 3860 | 63467583 |
Growth of eyelashes | 31.01 | 13.51 | 8 | 17571 | 214 | 63471229 |
Conjunctival ulcer | 30.82 | 13.51 | 6 | 17573 | 41 | 63471402 |
Superficial injury of eye | 30.10 | 13.51 | 8 | 17571 | 241 | 63471202 |
Incorrect dose administered | 29.96 | 13.51 | 57 | 17522 | 59911 | 63411532 |
Flat anterior chamber of eye | 29.35 | 13.51 | 6 | 17573 | 54 | 63471389 |
Blindness | 29.24 | 13.51 | 33 | 17546 | 21666 | 63449777 |
Obstructive airways disorder | 28.79 | 13.51 | 32 | 17547 | 20667 | 63450776 |
Liquid product physical issue | 27.99 | 13.51 | 11 | 17568 | 1171 | 63470272 |
Corneal epithelium defect | 27.36 | 13.51 | 8 | 17571 | 344 | 63471099 |
Wound | 27.13 | 13.51 | 6 | 17573 | 163257 | 63308186 |
Completed suicide | 27.13 | 13.51 | 4 | 17575 | 145669 | 63325774 |
Hallucination, visual | 27.12 | 13.51 | 30 | 17549 | 19268 | 63452175 |
Chronotropic incompetence | 26.93 | 13.51 | 6 | 17573 | 84 | 63471359 |
Erythema of eyelid | 26.93 | 13.51 | 13 | 17566 | 2273 | 63469170 |
Glaucoma surgery | 26.73 | 13.51 | 6 | 17573 | 87 | 63471356 |
Vitamin B12 decreased | 26.59 | 13.51 | 15 | 17564 | 3605 | 63467838 |
Atrioventricular block complete | 25.69 | 13.51 | 20 | 17559 | 8231 | 63463212 |
Haemangioma congenital | 25.39 | 13.51 | 8 | 17571 | 444 | 63470999 |
Hypopyon | 25.35 | 13.51 | 9 | 17570 | 723 | 63470720 |
Vitreous haemorrhage | 25.19 | 13.51 | 12 | 17567 | 2038 | 63469405 |
Arthralgia | 24.99 | 13.51 | 78 | 17501 | 569632 | 62901811 |
Conjunctival scar | 24.56 | 13.51 | 5 | 17574 | 44 | 63471399 |
Retinal detachment | 24.28 | 13.51 | 17 | 17562 | 5952 | 63465491 |
Keratitis interstitial | 24.06 | 13.51 | 4 | 17575 | 9 | 63471434 |
Foreign body in eye | 23.84 | 13.51 | 6 | 17573 | 145 | 63471298 |
Toxic anterior segment syndrome | 23.71 | 13.51 | 11 | 17568 | 1760 | 63469683 |
Conjunctivitis | 23.66 | 13.51 | 29 | 17550 | 20767 | 63450676 |
Sinoatrial block | 23.65 | 13.51 | 9 | 17570 | 879 | 63470564 |
Infusion related reaction | 23.58 | 13.51 | 20 | 17559 | 245501 | 63225942 |
Conjunctivitis allergic | 23.13 | 13.51 | 9 | 17570 | 933 | 63470510 |
Keratopathy | 22.96 | 13.51 | 8 | 17571 | 608 | 63470835 |
Hypersensitivity | 22.91 | 13.51 | 149 | 17430 | 292536 | 63178907 |
Fall | 22.83 | 13.51 | 186 | 17393 | 392148 | 63079295 |
Vitreous floaters | 21.99 | 13.51 | 16 | 17563 | 5950 | 63465493 |
Contraindicated product administered | 21.80 | 13.51 | 17 | 17562 | 217631 | 63253812 |
Corneal opacity | 21.49 | 13.51 | 8 | 17571 | 735 | 63470708 |
Corneal thickening | 21.45 | 13.51 | 4 | 17575 | 21 | 63471422 |
Endophthalmitis | 21.41 | 13.51 | 13 | 17566 | 3579 | 63467864 |
Blindness unilateral | 21.34 | 13.51 | 16 | 17563 | 6225 | 63465218 |
Drug intolerance | 21.14 | 13.51 | 33 | 17546 | 308628 | 63162815 |
Open angle glaucoma | 20.30 | 13.51 | 6 | 17573 | 268 | 63471175 |
Swelling | 20.26 | 13.51 | 28 | 17551 | 275350 | 63196093 |
Uveitis | 20.26 | 13.51 | 21 | 17558 | 12532 | 63458911 |
Eyelid irritation | 20.04 | 13.51 | 7 | 17572 | 536 | 63470907 |
Hepatic enzyme increased | 20.02 | 13.51 | 16 | 17563 | 202312 | 63269131 |
Discomfort | 19.56 | 13.51 | 11 | 17568 | 167363 | 63304080 |
Genital erythema | 19.47 | 13.51 | 4 | 17575 | 37 | 63471406 |
Dry eye | 19.44 | 13.51 | 38 | 17541 | 40723 | 63430720 |
Sinus bradycardia | 19.38 | 13.51 | 22 | 17557 | 14529 | 63456914 |
Blepharitis | 19.23 | 13.51 | 11 | 17568 | 2714 | 63468729 |
Dry mouth | 19.05 | 13.51 | 56 | 17523 | 77807 | 63393636 |
Product dose omission issue | 18.76 | 13.51 | 120 | 17459 | 234193 | 63237250 |
Sinonasal papilloma | 18.76 | 13.51 | 4 | 17575 | 45 | 63471398 |
Maternal exposure during pregnancy | 18.70 | 13.51 | 20 | 17559 | 220042 | 63251401 |
Eye disorder | 18.67 | 13.51 | 27 | 17552 | 22658 | 63448785 |
Intraocular pressure fluctuation | 18.52 | 13.51 | 4 | 17575 | 48 | 63471395 |
Lethargy | 18.47 | 13.51 | 45 | 17534 | 55962 | 63415481 |
Product physical consistency issue | 18.31 | 13.51 | 7 | 17572 | 692 | 63470751 |
Bronchopulmonary disease | 18.28 | 13.51 | 3 | 17576 | 6 | 63471437 |
Optic nerve cupping | 18.28 | 13.51 | 3 | 17576 | 6 | 63471437 |
Joint swelling | 18.04 | 13.51 | 40 | 17539 | 327626 | 63143817 |
No adverse event | 17.84 | 13.51 | 37 | 17542 | 41368 | 63430075 |
Nodal rhythm | 17.82 | 13.51 | 9 | 17570 | 1734 | 63469709 |
Hypotonia | 17.69 | 13.51 | 17 | 17562 | 9268 | 63462175 |
Achromotrichia acquired | 17.42 | 13.51 | 3 | 17576 | 9 | 63471434 |
Hypothermia | 17.19 | 13.51 | 20 | 17559 | 13561 | 63457882 |
Arthropathy | 17.14 | 13.51 | 24 | 17555 | 234768 | 63236675 |
Haemangioma | 16.64 | 13.51 | 10 | 17569 | 2702 | 63468741 |
Blood pressure systolic increased | 16.62 | 13.51 | 39 | 17540 | 47358 | 63424085 |
Conjunctival follicles | 16.38 | 13.51 | 3 | 17576 | 14 | 63471429 |
Symblepharon | 16.30 | 13.51 | 4 | 17575 | 87 | 63471356 |
Corneal endothelial cell loss | 16.21 | 13.51 | 3 | 17576 | 15 | 63471428 |
Small for dates baby | 16.00 | 13.51 | 11 | 17568 | 3740 | 63467703 |
Eye oedema | 15.98 | 13.51 | 8 | 17571 | 1512 | 63469931 |
Therapeutic product effect decreased | 15.92 | 13.51 | 18 | 17561 | 193169 | 63278274 |
Eye allergy | 15.90 | 13.51 | 7 | 17572 | 992 | 63470451 |
Product use issue | 15.64 | 13.51 | 23 | 17556 | 220497 | 63250946 |
Dacryocystitis | 15.22 | 13.51 | 3 | 17576 | 22 | 63471421 |
Iritis | 15.20 | 13.51 | 10 | 17569 | 3165 | 63468278 |
Conjunctival erosion | 15.07 | 13.51 | 4 | 17575 | 120 | 63471323 |
Intraocular pressure decreased | 15.07 | 13.51 | 4 | 17575 | 120 | 63471323 |
Eyelids pruritus | 15.00 | 13.51 | 7 | 17572 | 1135 | 63470308 |
Intraocular lens implant | 14.91 | 13.51 | 5 | 17574 | 338 | 63471105 |
Vertigo | 14.58 | 13.51 | 43 | 17536 | 59844 | 63411599 |
Photophobia | 14.53 | 13.51 | 21 | 17558 | 17614 | 63453829 |
Stag horn calculus | 14.26 | 13.51 | 4 | 17575 | 148 | 63471295 |
Iris neovascularisation | 14.22 | 13.51 | 3 | 17576 | 32 | 63471411 |
Intentional product use issue | 14.10 | 13.51 | 9 | 17570 | 127883 | 63343560 |
Herpes ophthalmic | 14.09 | 13.51 | 7 | 17572 | 1302 | 63470141 |
Haematemesis | 14.07 | 13.51 | 28 | 17551 | 30384 | 63441059 |
Nasopharyngitis | 14.02 | 13.51 | 31 | 17548 | 254226 | 63217217 |
Dizziness | 14.00 | 13.51 | 181 | 17398 | 429744 | 63041699 |
Psoriatic arthropathy | 13.97 | 13.51 | 4 | 17575 | 91516 | 63379927 |
Retinal vascular occlusion | 13.84 | 13.51 | 5 | 17574 | 422 | 63471021 |
Vitrectomy | 13.57 | 13.51 | 4 | 17575 | 177 | 63471266 |
Febrile neutropenia | 13.53 | 13.51 | 8 | 17571 | 118441 | 63353002 |
Therapeutic product effect incomplete | 13.52 | 13.51 | 9 | 17570 | 125047 | 63346396 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Treatment failure | 735.48 | 14.58 | 345 | 11617 | 46352 | 34898617 |
Intraocular pressure increased | 366.95 | 14.58 | 116 | 11846 | 5267 | 34939702 |
Eye irritation | 283.17 | 14.58 | 104 | 11858 | 7457 | 34937512 |
Eye pain | 179.45 | 14.58 | 89 | 11873 | 13373 | 34931596 |
Visual acuity reduced | 164.16 | 14.58 | 89 | 11873 | 16060 | 34928909 |
Ocular hyperaemia | 138.79 | 14.58 | 71 | 11891 | 11381 | 34933588 |
Vision blurred | 112.32 | 14.58 | 106 | 11856 | 45857 | 34899112 |
Corneal oedema | 91.52 | 14.58 | 29 | 11933 | 1322 | 34943647 |
Glaucoma | 90.00 | 14.58 | 45 | 11917 | 6867 | 34938102 |
Corneal deposits | 80.35 | 14.58 | 18 | 11944 | 206 | 34944763 |
Product delivery mechanism issue | 74.13 | 14.58 | 16 | 11946 | 152 | 34944817 |
Bradycardia | 71.26 | 14.58 | 107 | 11855 | 75311 | 34869658 |
Lacrimation increased | 70.53 | 14.58 | 41 | 11921 | 8441 | 34936528 |
Product quality issue | 65.53 | 14.58 | 51 | 11911 | 16984 | 34927985 |
Intraocular pressure test abnormal | 61.33 | 14.58 | 12 | 11950 | 66 | 34944903 |
Product container issue | 55.26 | 14.58 | 17 | 11945 | 702 | 34944267 |
Cataract | 50.25 | 14.58 | 53 | 11909 | 26133 | 34918836 |
Hyphaema | 49.91 | 14.58 | 15 | 11947 | 572 | 34944397 |
Anterior chamber disorder | 49.42 | 14.58 | 10 | 11952 | 67 | 34944902 |
Blindness | 49.41 | 14.58 | 41 | 11921 | 14945 | 34930024 |
Eye pruritus | 48.88 | 14.58 | 31 | 11931 | 7458 | 34937511 |
Toxic anterior segment syndrome | 43.43 | 14.58 | 16 | 11946 | 1153 | 34943816 |
Eye discharge | 41.50 | 14.58 | 18 | 11944 | 1988 | 34942981 |
Visual impairment | 41.44 | 14.58 | 56 | 11906 | 35746 | 34909223 |
Choroidal detachment | 36.81 | 14.58 | 11 | 11951 | 411 | 34944558 |
Foreign body sensation in eyes | 36.38 | 14.58 | 12 | 11950 | 622 | 34944347 |
Corneal disorder | 35.50 | 14.58 | 13 | 11949 | 921 | 34944048 |
Floppy iris syndrome | 35.35 | 14.58 | 10 | 11952 | 307 | 34944662 |
Ocular discomfort | 34.13 | 14.58 | 16 | 11946 | 2118 | 34942851 |
Dry eye | 33.25 | 14.58 | 27 | 11935 | 9548 | 34935421 |
Erythema of eyelid | 31.70 | 14.58 | 12 | 11950 | 933 | 34944036 |
Iridocyclitis | 31.51 | 14.58 | 14 | 11948 | 1638 | 34943331 |
Ocular hypertension | 29.33 | 14.58 | 11 | 11951 | 833 | 34944136 |
Visual acuity tests abnormal | 28.72 | 14.58 | 6 | 11956 | 48 | 34944921 |
Blindness unilateral | 27.66 | 14.58 | 18 | 11944 | 4524 | 34940445 |
Scleral hyperaemia | 27.00 | 14.58 | 6 | 11956 | 66 | 34944903 |
Eye infection | 25.97 | 14.58 | 16 | 11946 | 3657 | 34941312 |
Off label use | 24.99 | 14.58 | 68 | 11894 | 419456 | 34525513 |
Retinal detachment | 24.86 | 14.58 | 18 | 11944 | 5373 | 34939596 |
Ulcerative keratitis | 24.71 | 14.58 | 12 | 11950 | 1717 | 34943252 |
Eye swelling | 24.27 | 14.58 | 23 | 11939 | 9972 | 34934997 |
Eyelid irritation | 23.75 | 14.58 | 6 | 11956 | 118 | 34944851 |
Completed suicide | 23.38 | 14.58 | 3 | 11959 | 98165 | 34846804 |
Eyelid oedema | 23.38 | 14.58 | 17 | 11945 | 5107 | 34939862 |
Conjunctival oedema | 23.19 | 14.58 | 8 | 11954 | 476 | 34944493 |
Administration site discomfort | 23.12 | 14.58 | 5 | 11957 | 48 | 34944921 |
Intraocular pressure decreased | 21.52 | 14.58 | 5 | 11957 | 68 | 34944901 |
Product packaging quantity issue | 21.41 | 14.58 | 9 | 11953 | 920 | 34944049 |
Eye disorder | 21.39 | 14.58 | 21 | 11941 | 9507 | 34935462 |
Atrioventricular block second degree | 20.62 | 14.58 | 14 | 11948 | 3774 | 34941195 |
Scleral disorder | 20.60 | 14.58 | 4 | 11958 | 21 | 34944948 |
Trabeculectomy | 20.44 | 14.58 | 4 | 11958 | 22 | 34944947 |
Growth of eyelashes | 19.81 | 14.58 | 5 | 11957 | 98 | 34944871 |
Abnormal sensation in eye | 19.76 | 14.58 | 8 | 11954 | 744 | 34944225 |
Uveitis | 19.57 | 14.58 | 18 | 11944 | 7517 | 34937452 |
Accidental exposure to product | 19.54 | 14.58 | 23 | 11939 | 12779 | 34932190 |
Hypotony of eye | 19.40 | 14.58 | 5 | 11957 | 107 | 34944862 |
Macular degeneration | 19.32 | 14.58 | 11 | 11951 | 2175 | 34942794 |
Corneal degeneration | 18.83 | 14.58 | 4 | 11958 | 35 | 34944934 |
Anterior chamber inflammation | 18.67 | 14.58 | 6 | 11956 | 286 | 34944683 |
Cataract nuclear | 18.65 | 14.58 | 7 | 11955 | 531 | 34944438 |
Visual field defect | 18.50 | 14.58 | 14 | 11948 | 4469 | 34940500 |
Conjunctival hyperaemia | 18.36 | 14.58 | 11 | 11951 | 2391 | 34942578 |
Conjunctival scar | 18.32 | 14.58 | 5 | 11957 | 134 | 34944835 |
Blepharitis | 17.61 | 14.58 | 9 | 11953 | 1436 | 34943533 |
Corneal epithelium defect | 17.14 | 14.58 | 6 | 11956 | 373 | 34944596 |
Eyelids pruritus | 17.13 | 14.58 | 5 | 11957 | 172 | 34944797 |
Funguria | 17.11 | 14.58 | 4 | 11958 | 56 | 34944913 |
Punctate keratitis | 17.08 | 14.58 | 6 | 11956 | 377 | 34944592 |
Photophobia | 16.86 | 14.58 | 16 | 11946 | 6948 | 34938021 |
Eye haemorrhage | 16.79 | 14.58 | 13 | 11949 | 4292 | 34940677 |
Coronavirus infection | 16.78 | 14.58 | 13 | 11949 | 4294 | 34940675 |
Optic nerve cupping | 16.73 | 14.58 | 4 | 11958 | 62 | 34944907 |
Cystoid macular oedema | 16.72 | 14.58 | 7 | 11955 | 708 | 34944261 |
Electrolyte depletion | 16.55 | 14.58 | 5 | 11957 | 194 | 34944775 |
Eye inflammation | 16.55 | 14.58 | 10 | 11952 | 2208 | 34942761 |
Cardiovascular insufficiency | 16.30 | 14.58 | 9 | 11953 | 1678 | 34943291 |
Dizziness | 16.25 | 14.58 | 129 | 11833 | 218392 | 34726577 |
Dermatitis | 16.12 | 14.58 | 18 | 11944 | 9450 | 34935519 |
Instillation site irritation | 15.92 | 14.58 | 3 | 11959 | 13 | 34944956 |
Madarosis | 15.69 | 14.58 | 5 | 11957 | 232 | 34944737 |
Intraocular pressure fluctuation | 15.57 | 14.58 | 3 | 11959 | 15 | 34944954 |
Liquid product physical issue | 15.49 | 14.58 | 6 | 11956 | 496 | 34944473 |
Hypersensitivity | 15.45 | 14.58 | 51 | 11911 | 60984 | 34883985 |
Glaucoma surgery | 15.26 | 14.58 | 3 | 11959 | 17 | 34944952 |
Eyelid margin crusting | 15.25 | 14.58 | 5 | 11957 | 254 | 34944715 |
Cutis laxa | 15.24 | 14.58 | 4 | 11958 | 92 | 34944877 |
Retinal haemorrhage | 14.88 | 14.58 | 13 | 11949 | 5076 | 34939893 |
Angle closure glaucoma | 14.77 | 14.58 | 7 | 11955 | 950 | 34944019 |
Oversensing | 14.71 | 14.58 | 3 | 11959 | 21 | 34944948 |
Corneal opacity | 14.59 | 14.58 | 6 | 11956 | 580 | 34944389 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intraocular pressure increased | 522.42 | 12.06 | 164 | 21870 | 9041 | 79713313 |
Eye irritation | 336.55 | 12.06 | 147 | 21887 | 20534 | 79701820 |
Eye pain | 234.97 | 12.06 | 140 | 21894 | 37438 | 79684916 |
Visual acuity reduced | 224.86 | 12.06 | 125 | 21909 | 29344 | 79693010 |
Ocular hyperaemia | 213.45 | 12.06 | 119 | 21915 | 28087 | 79694267 |
Vision blurred | 157.07 | 12.06 | 169 | 21865 | 105729 | 79616625 |
Glaucoma | 153.94 | 12.06 | 85 | 21949 | 19676 | 79702678 |
Bradycardia | 153.27 | 12.06 | 188 | 21846 | 135369 | 79586985 |
Corneal oedema | 137.49 | 12.06 | 44 | 21990 | 2576 | 79719778 |
Lacrimation increased | 105.86 | 12.06 | 70 | 21964 | 22407 | 79699947 |
Eye pruritus | 89.52 | 12.06 | 61 | 21973 | 20509 | 79701845 |
Choroidal detachment | 89.30 | 12.06 | 23 | 22011 | 613 | 79721741 |
Corneal deposits | 84.73 | 12.06 | 21 | 22013 | 477 | 79721877 |
Corneal disorder | 78.76 | 12.06 | 28 | 22006 | 2263 | 79720091 |
Eye discharge | 76.30 | 12.06 | 36 | 21998 | 5998 | 79716356 |
Choroidal effusion | 73.64 | 12.06 | 20 | 22014 | 657 | 79721697 |
Iris adhesions | 73.04 | 12.06 | 19 | 22015 | 527 | 79721827 |
Intraocular pressure test abnormal | 68.23 | 12.06 | 14 | 22020 | 129 | 79722225 |
Total lung capacity increased | 67.48 | 12.06 | 25 | 22009 | 2273 | 79720081 |
Cataract | 65.07 | 12.06 | 83 | 21951 | 62037 | 79660317 |
Trabeculectomy | 60.68 | 12.06 | 11 | 22023 | 48 | 79722306 |
Toxic anterior segment syndrome | 59.52 | 12.06 | 24 | 22010 | 2740 | 79719614 |
Ulcerative keratitis | 59.25 | 12.06 | 26 | 22008 | 3663 | 79718691 |
Conjunctival hyperaemia | 57.87 | 12.06 | 27 | 22007 | 4386 | 79717968 |
Frustration tolerance decreased | 52.26 | 12.06 | 30 | 22004 | 7472 | 79714882 |
Hyphaema | 50.81 | 12.06 | 16 | 22018 | 888 | 79721466 |
Floppy iris syndrome | 50.34 | 12.06 | 13 | 22021 | 350 | 79722004 |
Iridocyclitis | 49.62 | 12.06 | 23 | 22011 | 3681 | 79718673 |
Anterior chamber disorder | 49.60 | 12.06 | 11 | 22023 | 151 | 79722203 |
Hypotony of eye | 49.59 | 12.06 | 12 | 22022 | 246 | 79722108 |
Visual field defect | 49.58 | 12.06 | 31 | 22003 | 9014 | 79713340 |
Eye inflammation | 45.62 | 12.06 | 26 | 22008 | 6387 | 79715967 |
Completed suicide | 45.09 | 12.06 | 7 | 22027 | 245760 | 79476594 |
Blindness | 45.04 | 12.06 | 47 | 21987 | 28336 | 79694018 |
Angle closure glaucoma | 44.66 | 12.06 | 20 | 22014 | 2956 | 79719398 |
Foreign body sensation in eyes | 43.95 | 12.06 | 18 | 22016 | 2139 | 79720215 |
Forced expiratory volume decreased | 43.38 | 12.06 | 27 | 22007 | 7787 | 79714567 |
Peak expiratory flow rate decreased | 42.21 | 12.06 | 13 | 22021 | 670 | 79721684 |
Cystoid macular oedema | 41.97 | 12.06 | 17 | 22017 | 1963 | 79720391 |
Retinal detachment | 41.61 | 12.06 | 28 | 22006 | 9219 | 79713135 |
Corneal epithelium defect | 41.56 | 12.06 | 13 | 22021 | 706 | 79721648 |
Respiration abnormal | 40.95 | 12.06 | 26 | 22008 | 7762 | 79714592 |
Ocular discomfort | 40.35 | 12.06 | 22 | 22012 | 4961 | 79717393 |
Uveitis | 40.32 | 12.06 | 35 | 21999 | 16795 | 79705559 |
Corneal degeneration | 40.02 | 12.06 | 9 | 22025 | 132 | 79722222 |
Pulmonary thrombosis | 39.03 | 12.06 | 30 | 22004 | 12141 | 79710213 |
Erythema of eyelid | 37.70 | 12.06 | 17 | 22017 | 2553 | 79719801 |
Punctate keratitis | 37.53 | 12.06 | 13 | 22021 | 973 | 79721381 |
Conjunctival scar | 36.16 | 12.06 | 9 | 22025 | 208 | 79722146 |
Ocular hypertension | 35.52 | 12.06 | 14 | 22020 | 1506 | 79720848 |
Endophthalmitis | 35.15 | 12.06 | 22 | 22012 | 6406 | 79715948 |
Lung diffusion test decreased | 33.92 | 12.06 | 13 | 22021 | 1297 | 79721057 |
Procollagen type I C-terminal propeptide increased | 33.52 | 12.06 | 6 | 22028 | 24 | 79722330 |
Product quality issue | 33.42 | 12.06 | 44 | 21990 | 33896 | 79688458 |
Instillation site irritation | 33.42 | 12.06 | 7 | 22027 | 72 | 79722282 |
Sinus bradycardia | 33.41 | 12.06 | 38 | 21996 | 25209 | 79697145 |
Serum procollagen type I N-terminal propeptide increased | 32.59 | 12.06 | 6 | 22028 | 29 | 79722325 |
Fall | 31.82 | 12.06 | 237 | 21797 | 487392 | 79234962 |
Vitreous haemorrhage | 31.76 | 12.06 | 17 | 22017 | 3696 | 79718658 |
Blepharitis | 31.58 | 12.06 | 16 | 22018 | 3108 | 79719246 |
Forced vital capacity decreased | 30.33 | 12.06 | 13 | 22021 | 1730 | 79720624 |
Visual impairment | 29.41 | 12.06 | 73 | 21961 | 92058 | 79630296 |
Eyelid margin crusting | 29.19 | 12.06 | 11 | 22023 | 1048 | 79721306 |
Flat anterior chamber of eye | 28.41 | 12.06 | 7 | 22027 | 155 | 79722199 |
Intraocular pressure fluctuation | 28.36 | 12.06 | 6 | 22028 | 65 | 79722289 |
Atrioventricular block complete | 27.24 | 12.06 | 28 | 22006 | 16582 | 79705772 |
Product container issue | 27.08 | 12.06 | 11 | 22023 | 1280 | 79721074 |
Chronotropic incompetence | 26.31 | 12.06 | 6 | 22028 | 94 | 79722260 |
Synovitis | 26.08 | 12.06 | 5 | 22029 | 150729 | 79571625 |
Blindness unilateral | 25.95 | 12.06 | 20 | 22014 | 8126 | 79714228 |
Abnormal sensation in eye | 25.87 | 12.06 | 12 | 22022 | 1923 | 79720431 |
Nodal rhythm | 25.83 | 12.06 | 14 | 22020 | 3121 | 79719233 |
Retinal disorder | 25.23 | 12.06 | 12 | 22022 | 2035 | 79720319 |
Visual acuity tests abnormal | 25.13 | 12.06 | 6 | 22028 | 116 | 79722238 |
Conjunctival oedema | 24.74 | 12.06 | 10 | 22024 | 1148 | 79721206 |
Vitamin B12 decreased | 24.37 | 12.06 | 14 | 22020 | 3491 | 79718863 |
Eye disorder | 24.06 | 12.06 | 31 | 22003 | 23381 | 79698973 |
Conjunctivitis allergic | 24.04 | 12.06 | 11 | 22023 | 1709 | 79720645 |
Atrioventricular block | 23.62 | 12.06 | 24 | 22010 | 14017 | 79708337 |
Dizziness | 23.37 | 12.06 | 235 | 21799 | 526206 | 79196148 |
Optic nerve cupping | 23.32 | 12.06 | 5 | 22029 | 58 | 79722296 |
Systemic lupus erythematosus | 23.26 | 12.06 | 3 | 22031 | 121146 | 79601208 |
Corneal decompensation | 23.09 | 12.06 | 5 | 22029 | 61 | 79722293 |
Product delivery mechanism issue | 22.94 | 12.06 | 6 | 22028 | 170 | 79722184 |
Corneal opacity | 22.46 | 12.06 | 9 | 22025 | 1011 | 79721343 |
Growth of eyelashes | 22.24 | 12.06 | 6 | 22028 | 192 | 79722162 |
Conjunctivitis | 21.79 | 12.06 | 31 | 22003 | 25684 | 79696670 |
Arthralgia | 21.69 | 12.06 | 83 | 21951 | 571720 | 79150634 |
Ectropion | 21.69 | 12.06 | 7 | 22027 | 421 | 79721933 |
Corneal thickening | 21.62 | 12.06 | 4 | 22030 | 20 | 79722334 |
Hypopyon | 21.47 | 12.06 | 9 | 22025 | 1133 | 79721221 |
Atrioventricular block second degree | 21.23 | 12.06 | 17 | 22017 | 7295 | 79715059 |
Keratopathy | 21.09 | 12.06 | 9 | 22025 | 1185 | 79721169 |
Iritis | 20.59 | 12.06 | 13 | 22021 | 3842 | 79718512 |
Glaucoma surgery | 20.37 | 12.06 | 5 | 22029 | 109 | 79722245 |
Thermal burns of eye | 20.33 | 12.06 | 5 | 22029 | 110 | 79722244 |
Vertigo | 20.24 | 12.06 | 53 | 21981 | 69029 | 79653325 |
Sinoatrial block | 20.02 | 12.06 | 9 | 22025 | 1342 | 79721012 |
Hypotonia | 19.86 | 12.06 | 21 | 22013 | 12849 | 79709505 |
Anterior chamber inflammation | 19.67 | 12.06 | 7 | 22027 | 567 | 79721787 |
Administration site discomfort | 19.35 | 12.06 | 5 | 22029 | 135 | 79722219 |
Sinonasal papilloma | 18.85 | 12.06 | 4 | 22030 | 44 | 79722310 |
Abdominal discomfort | 18.84 | 12.06 | 25 | 22009 | 250702 | 79471652 |
Macular oedema | 18.67 | 12.06 | 14 | 22020 | 5460 | 79716894 |
Abdominal pain | 18.62 | 12.06 | 51 | 21983 | 389518 | 79332836 |
Hepatic enzyme increased | 18.54 | 12.06 | 14 | 22020 | 182596 | 79539758 |
Dry eye | 18.36 | 12.06 | 35 | 21999 | 36896 | 79685458 |
Infusion related reaction | 18.30 | 12.06 | 22 | 22012 | 230215 | 79492139 |
Hyponatraemia | 18.16 | 12.06 | 97 | 21937 | 177751 | 79544603 |
Toxicity to various agents | 18.11 | 12.06 | 58 | 21976 | 421482 | 79300872 |
Macular fibrosis | 18.10 | 12.06 | 7 | 22027 | 716 | 79721638 |
Photophobia | 17.76 | 12.06 | 25 | 22009 | 20503 | 79701851 |
Pain | 17.65 | 12.06 | 118 | 21916 | 703684 | 79018670 |
Symblepharon | 17.56 | 12.06 | 5 | 22029 | 196 | 79722158 |
Superficial injury of eye | 17.53 | 12.06 | 5 | 22029 | 197 | 79722157 |
Retinal haemorrhage | 17.52 | 12.06 | 16 | 22018 | 8201 | 79714153 |
Corneal endothelial cell loss | 17.43 | 12.06 | 3 | 22031 | 9 | 79722345 |
Loss of consciousness | 17.42 | 12.06 | 92 | 21942 | 167851 | 79554503 |
Maternal exposure during pregnancy | 17.34 | 12.06 | 8 | 22026 | 136530 | 79585824 |
Eyelid irritation | 17.24 | 12.06 | 6 | 22028 | 455 | 79721899 |
Vitreous floaters | 17.20 | 12.06 | 15 | 22019 | 7241 | 79715113 |
Arrhythmia | 16.93 | 12.06 | 46 | 21988 | 61226 | 79661128 |
Vitreal cells | 16.92 | 12.06 | 4 | 22030 | 74 | 79722280 |
Confusional state | 16.60 | 12.06 | 147 | 21887 | 317850 | 79404504 |
Bronchopulmonary disease | 16.38 | 12.06 | 3 | 22031 | 14 | 79722340 |
Drug intolerance | 16.35 | 12.06 | 30 | 22004 | 264089 | 79458265 |
Hallucination, visual | 16.25 | 12.06 | 31 | 22003 | 32698 | 79689656 |
Heterochromia iridis | 16.05 | 12.06 | 3 | 22031 | 16 | 79722338 |
Off label use | 16.01 | 12.06 | 167 | 21867 | 907048 | 78815306 |
Obstructive airways disorder | 15.87 | 12.06 | 30 | 22004 | 31429 | 79690925 |
Product complaint | 15.84 | 12.06 | 19 | 22015 | 13330 | 79709024 |
Corneal pigmentation | 15.75 | 12.06 | 3 | 22031 | 18 | 79722336 |
Conjunctival follicles | 15.75 | 12.06 | 3 | 22031 | 18 | 79722336 |
Achromotrichia acquired | 15.75 | 12.06 | 3 | 22031 | 18 | 79722336 |
Corneal infection | 15.66 | 12.06 | 4 | 22030 | 103 | 79722251 |
Dermatitis | 15.61 | 12.06 | 24 | 22010 | 21297 | 79701057 |
Eye swelling | 15.59 | 12.06 | 27 | 22007 | 26441 | 79695913 |
Rhinocerebral mucormycosis | 15.52 | 12.06 | 7 | 22027 | 1051 | 79721303 |
Therapeutic product effect incomplete | 15.51 | 12.06 | 10 | 22024 | 141635 | 79580719 |
Corneal scar | 15.45 | 12.06 | 5 | 22029 | 303 | 79722051 |
Scleral hyperaemia | 15.36 | 12.06 | 5 | 22029 | 309 | 79722045 |
Eyelid ptosis | 15.26 | 12.06 | 17 | 22017 | 11027 | 79711327 |
Product substitution issue | 15.11 | 12.06 | 23 | 22011 | 20233 | 79702121 |
Contraindicated product administered | 14.84 | 12.06 | 13 | 22021 | 157525 | 79564829 |
Liquid product physical issue | 14.83 | 12.06 | 7 | 22027 | 1167 | 79721187 |
Keratitis interstitial | 14.78 | 12.06 | 3 | 22031 | 26 | 79722328 |
Metamorphopsia | 14.19 | 12.06 | 7 | 22027 | 1286 | 79721068 |
Iris transillumination defect | 14.09 | 12.06 | 4 | 22030 | 155 | 79722199 |
Eyelid oedema | 13.87 | 12.06 | 18 | 22016 | 13669 | 79708685 |
Electrolyte depletion | 13.86 | 12.06 | 5 | 22029 | 421 | 79721933 |
Subretinal fluid | 13.80 | 12.06 | 6 | 22028 | 826 | 79721528 |
Chorioretinal disorder | 13.78 | 12.06 | 4 | 22030 | 168 | 79722186 |
Oversensing | 13.75 | 12.06 | 3 | 22031 | 38 | 79722316 |
Product use issue | 13.74 | 12.06 | 23 | 22011 | 209799 | 79512555 |
Choroidal haemorrhage | 13.71 | 12.06 | 4 | 22030 | 171 | 79722183 |
Eye oedema | 13.70 | 12.06 | 8 | 22026 | 2055 | 79720299 |
Stag horn calculus | 13.69 | 12.06 | 4 | 22030 | 172 | 79722182 |
Intraocular pressure decreased | 13.56 | 12.06 | 4 | 22030 | 178 | 79722176 |
Cardiovascular insufficiency | 13.35 | 12.06 | 9 | 22025 | 2972 | 79719382 |
Corneal thinning | 13.32 | 12.06 | 4 | 22030 | 189 | 79722165 |
Herpes ophthalmic | 13.17 | 12.06 | 7 | 22027 | 1500 | 79720854 |
Extrasystoles | 13.07 | 12.06 | 13 | 22021 | 7406 | 79714948 |
Alkalosis hypochloraemic | 13.04 | 12.06 | 5 | 22029 | 499 | 79721855 |
Cataract subcapsular | 12.97 | 12.06 | 6 | 22028 | 955 | 79721399 |
Scleral disorder | 12.94 | 12.06 | 4 | 22030 | 209 | 79722145 |
Gastrointestinal haemorrhage | 12.72 | 12.06 | 77 | 21957 | 147642 | 79574712 |
Seborrhoeic keratosis | 12.71 | 12.06 | 8 | 22026 | 2352 | 79720002 |
Intentional product use issue | 12.66 | 12.06 | 14 | 22020 | 152098 | 79570256 |
Blood pressure systolic increased | 12.63 | 12.06 | 44 | 21990 | 66942 | 79655412 |
Keratitis | 12.45 | 12.06 | 10 | 22024 | 4312 | 79718042 |
Pupillary reflex impaired | 12.39 | 12.06 | 9 | 22025 | 3344 | 79719010 |
Dacryocystitis | 12.28 | 12.06 | 3 | 22031 | 64 | 79722290 |
Myocardial infarction | 12.25 | 12.06 | 90 | 21944 | 184039 | 79538315 |
Retinal vascular occlusion | 12.14 | 12.06 | 5 | 22029 | 602 | 79721752 |
None
Source | Code | Description |
---|---|---|
ATC | C07AA06 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, non-selective |
ATC | C07BA06 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS AND THIAZIDES Beta blocking agents, non-selective, and thiazides |
ATC | C07DA06 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, THIAZIDES AND OTHER DIURETICS Beta blocking agents, non-selective, thiazides and other diuretics |
ATC | S01ED01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Beta blocking agents |
ATC | S01ED51 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIGLAUCOMA PREPARATIONS AND MIOTICS Beta blocking agents |
CHEBI has role | CHEBI:35530 | beta-adrenergic blockers |
CHEBI has role | CHEBI:35674 | antihypertensive drugs |
CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
CHEBI has role | CHEBI:39456 | antiglaucoma agent |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D000319 | Adrenergic beta-Antagonists |
MeSH PA | D000889 | Anti-Arrhythmia Agents |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D018377 | Neurotransmitter Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Ocular hypertension | indication | 4210003 | DOID:9282 |
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Open-angle glaucoma | indication | 84494001 | DOID:1067 |
Myocardial Reinfarction Prevention | indication | ||
Migraine Prevention | indication | ||
Malignant glaucoma | off-label use | 10100008 | |
Aphakic glaucoma | off-label use | 15374009 | |
Secondary glaucoma | off-label use | 95717004 | |
Angina pectoris | off-label use | 194828000 | |
Angle-closure glaucoma | off-label use | 392291006 | DOID:13550 |
Mitral valve prolapse | off-label use | 409712001 | |
Stalled wound | off-label use | 789507005 | |
Anuria | contraindication | 2472002 | DOID:2983 |
Bronchospasm | contraindication | 4386001 | |
Hypercholesterolemia | contraindication | 13644009 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Dehydration | contraindication | 34095006 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Depressive disorder | contraindication | 35489007 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Anaphylaxis | contraindication | 39579001 | |
Hypokalemia | contraindication | 43339004 | |
Sinus bradycardia | contraindication | 49710005 | |
General anesthesia | contraindication | 50697003 | |
Thromboangiitis obliterans | contraindication | 52403007 | DOID:12918 |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Acute nephropathy | contraindication | 58574008 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Pulmonary emphysema | contraindication | 87433001 | |
Cardiogenic shock | contraindication | 89138009 | |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Acute disease of cardiovascular system | contraindication | 128487001 | |
Hypomagnesemia | contraindication | 190855004 | |
Partial atrioventricular block | contraindication | 195039008 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Hypoglycemic disorder | contraindication | 237630007 | |
Raynaud's phenomenon | contraindication | 266261006 | |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
Right ventricular failure | contraindication | 367363000 | |
Azotemia | contraindication | 445009001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.15 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Beta-1 adrenergic receptor | GPCR | ANTAGONIST | Ki | 9 | WOMBAT-PK | CHEMBL | |||
Beta-2 adrenergic receptor | GPCR | ANTAGONIST | Ki | 9.70 | WOMBAT-PK | CHEMBL | |||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 5.81 | DRUG MATRIX | |||||
Beta-3 adrenergic receptor | GPCR | Ki | 6.47 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.21 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Kd | 9.78 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Kd | 9.44 | CHEMBL |
ID | Source |
---|---|
4019949 | VUID |
N0000148034 | NUI |
D00378 | KEGG_DRUG |
26921-17-5 | SECONDARY_CAS_RN |
4017930 | VANDF |
4019949 | VANDF |
C0040233 | UMLSCUI |
CHEBI:60787 | CHEBI |
TIM | PDB_CHEM_ID |
CHEMBL499 | ChEMBL_ID |
DB00373 | DRUGBANK_ID |
CHEMBL1200870 | ChEMBL_ID |
D013999 | MESH_DESCRIPTOR_UI |
33624 | PUBCHEM_CID |
565 | IUPHAR_LIGAND_ID |
817W3C6175 | UNII |
10600 | RXNORM |
24737 | MMSL |
5585 | MMSL |
6436 | MMSL |
d00139 | MMSL |
001856 | NDDF |
004741 | NDDF |
372880004 | SNOMEDCT_US |
75359005 | SNOMEDCT_US |
85591001 | SNOMEDCT_US |
91524-16-2 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
COMBIGAN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-9211 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 26 sections |
COMBIGAN | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0023-9211 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 26 sections |
Timoptic in Ocudose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-1496 | SOLUTION | 6.80 mg | OPHTHALMIC | NDA | 20 sections |
Timoptic in Ocudose | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0187-1498 | SOLUTION | 3.40 mg | OPHTHALMIC | NDA | 20 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0055 | TABLET | 5 mg | ORAL | ANDA | 22 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0221 | TABLET | 10 mg | ORAL | ANDA | 22 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-0715 | TABLET | 20 mg | ORAL | ANDA | 22 sections |
Dorzolamide Hydrochloride-Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-1763 | SOLUTION | 5 mg | OPHTHALMIC | ANDA | 25 sections |
Brimonidine Tartrate/Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0591-2422 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 22 sections |
Brimonidine Tartrate and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0781-7186 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 23 sections |
Brimonidine Tartrate and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0781-7186 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 23 sections |
Brimonidine Tartrate and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0832-1425 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 27 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-618 | TABLET | 5 mg | ORAL | ANDA | 14 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-619 | TABLET | 10 mg | ORAL | ANDA | 14 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13811-620 | TABLET | 20 mg | ORAL | ANDA | 14 sections |
DORZOLAMIDE HYDROCHLORIDE TIMOLOL MALETAE | Human Prescription Drug Label | 2 | 14445-405 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 24 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-189 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 25 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-189 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 25 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-288 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 23 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-288 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 23 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-289 | SOLUTION/ DROPS | 2.50 mg | OPHTHALMIC | ANDA | 23 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-289 | SOLUTION/ DROPS | 2.50 mg | OPHTHALMIC | ANDA | 23 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-365 | SOLUTION/ DROPS | 2.50 mg | OPHTHALMIC | ANDA | 22 sections |
Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-366 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 22 sections |
Dorzolamide HCl and Timolol Maleate | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-514 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 28 sections |
COSOPT PF | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-604 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 26 sections |
COSOPT PF | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-604 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 26 sections |
COSOPT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-605 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 28 sections |
COSOPT | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17478-605 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 28 sections |
Istalol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-004 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 24 sections |