tertatolol Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 2605 83688-84-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tertatolol
  • dl-Tertatolol
  • Molecular weight: 295.44
  • Formula: C16H25NO2S
  • CLOGP: 3.12
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.49
  • ALOGS: -4.13
  • ROTB: 6

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AA16 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 1A GPCR Ki 8.09 PDSP
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 8.60 IUPHAR
5-hydroxytryptamine receptor 1A GPCR Ki 8.11 CHEMBL
Beta-3 adrenergic receptor Unclassified ANTAGONIST Ki 7 IUPHAR
Beta-3 adrenergic receptor Unclassified ANTAGONIST Ki 7 IUPHAR

External reference:

IDSource
C0076166 UMLSCUI
D07182 KEGG_DRUG
37840 RXNORM
005762 NDDF
716124003 SNOMEDCT_US
9ZO341YQXP UNII
5211 INN_ID
CHEBI:135244 CHEBI
CHEMBL434200 ChEMBL_ID
36920 PUBCHEM_CID
DB13775 DRUGBANK_ID
571 IUPHAR_LIGAND_ID
C005632 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None