bupranolol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 433 14556-46-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bupranolol
  • (+/-)-Bupranolol
  • bupranol
  • bupranolol hydrochloride
  • bupranolol HCl
An adrenergic-beta-2 antagonist that has been used for cardiac arrhythmia, angina pectoris, hypertension, glaucoma, and as an antithrombotic.
  • Molecular weight: 271.79
  • Formula: C14H22ClNO2
  • CLOGP: 3.10
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.49
  • ALOGS: -3.28
  • ROTB: 6

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 7.41 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AA19 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Glaucoma indication 23986001 DOID:1686
Hypertensive disorder indication 38341003 DOID:10763




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 9 IUPHAR IUPHAR
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 9.10 IUPHAR IUPHAR
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 7.30 IUPHAR

External reference:

IDSource
N0000166825 NUI
D01454 KEGG_DRUG
15148-80-8 SECONDARY_CAS_RN
1817 RXNORM
C0006403 UMLSCUI
CHEBI:135123 CHEBI
CHEMBL305380 ChEMBL_ID
DB08808 DRUGBANK_ID
D002046 MESH_DESCRIPTOR_UI
2475 PUBCHEM_CID
550 IUPHAR_LIGAND_ID
3166 INN_ID
858YGI5PIT UNII
006894 NDDF
006895 NDDF

Pharmaceutical products:

None