nilvadipine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 1934 75530-68-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • FR-34235
  • nilvadipine
  • nivaldipine
  • nivadil
  • Molecular weight: 385.38
  • Formula: C19H19N3O6
  • CLOGP: 3.04
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 131.56
  • ALOGS: -4.49
  • ROTB: 7

Drug dosage:

DoseUnitRoute
8 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.92 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 14 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1992 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA10 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.64 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel WOMBAT-PK
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel WOMBAT-PK
Voltage-dependent calcium channel gamma-1 subunit Ion channel WOMBAT-PK

External reference:

IDSource
D01908 KEGG_DRUG
C0060717 UMLSCUI
CHEBI:31911 CHEBI
CHEMBL517427 ChEMBL_ID
DB06712 DRUGBANK_ID
C035100 MESH_SUPPLEMENTAL_RECORD_UI
10160 IUPHAR_LIGAND_ID
5459 INN_ID
0214FUT37J UNII
4494 PUBCHEM_CID
53692 RXNORM
006271 NDDF
713436005 SNOMEDCT_US

Pharmaceutical products:

None