AI ASSISTANT
Ask DrugCentral
Explore drug information in your own words.
Type a question in the search bar above to get started. Each question is answered independently.
AI can make mistakes. Verify answers against the original sources before relying on them.
methylprednisolone aceponate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prednisone and prednisolone derivatives | 1769 | 86401-95-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.12 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 82 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,STK33,SYK,TEK | 27 | |||
| kinase-selectivity-class | AXL,GRK2,MAP2K6 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Steroid withdrawal syndrome | 72.55 | 38.46 | 11 | 736 | 665 | 90627035 |
| Coagulation test abnormal | 61.38 | 38.46 | 10 | 737 | 961 | 90626739 |
| Pelvic venous thrombosis | 60.63 | 38.46 | 11 | 736 | 1990 | 90625710 |
| Euphoric mood | 55.28 | 38.46 | 12 | 735 | 5397 | 90622303 |
| Erythrodermic psoriasis | 53.12 | 38.46 | 9 | 738 | 1097 | 90626603 |
| Stupor | 44.11 | 38.46 | 10 | 737 | 5472 | 90622228 |
| Pulmonary embolism | 42.70 | 38.46 | 21 | 726 | 130799 | 90496901 |
| Deep vein thrombosis | 40.04 | 38.46 | 18 | 729 | 91602 | 90536098 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Steroid withdrawal syndrome | 37.87 | 32.44 | 6 | 550 | 303 | 42620476 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Steroid withdrawal syndrome | 65.15 | 29.44 | 11 | 1264 | 934 | 110587090 |
| Coagulation test abnormal | 53.10 | 29.44 | 10 | 1265 | 1576 | 110586448 |
| Pelvic venous thrombosis | 47.56 | 29.44 | 10 | 1265 | 2754 | 110585270 |
| Euphoric mood | 45.40 | 29.44 | 12 | 1263 | 8815 | 110579209 |
| Erythrodermic psoriasis | 44.71 | 29.44 | 9 | 1266 | 2001 | 110586023 |
| Stupor | 36.67 | 29.44 | 10 | 1265 | 8255 | 110579769 |
| Pulmonary embolism | 35.51 | 29.44 | 25 | 1250 | 214449 | 110373575 |
| Transaminases increased | 34.20 | 29.44 | 16 | 1259 | 63374 | 110524650 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AC14 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000932 | Antiemetics |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D018696 | Neuroprotective Agents |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:37962 | adrenergic agents |
| CHEBI has role | CHEBI:50919 | antiemetico |
| CHEBI has role | CHEBI:63726 | neuroprotective agents |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Related Drugs by ATC class:
D07AC Corticosteroids, potent (group III) 20 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.17 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D07203 | KEGG_DRUG |
| 4018068 | VANDF |
| C0174938 | UMLSCUI |
| CHEBI:135762 | CHEBI |
| CHEMBL1697782 | ChEMBL_ID |
| DB14643 | DRUGBANK_ID |
| C078007 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5524 | INN_ID |
| ET54W9J4U2 | UNII |
| 63019 | PUBCHEM_CID |
| 62136 | RXNORM |
| 1041 | MMSL |
| 5093 | MMSL |
| d00293 | MMSL |
| 002160 | NDDF |
| 006227 | NDDF |
| 116593003 | SNOMEDCT_US |
| 27242001 | SNOMEDCT_US |
| 708199003 | SNOMEDCT_US |
| C0025815 | UMLSCUI |
| DB00959 | DRUGBANK_ID |
| 6741 | PUBCHEM_CID |
| 732 | INN_ID |
| D008775 | MESH_DESCRIPTOR_UI |
| CHEBI:6888 | CHEBI |
| ET54W9J4U2 | INXIGHT DRUGS |
Pharmaceutical products:
None