halometasone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 1352 50629-82-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • halometasone
  • halomethasone
  • sicorten
  • Molecular weight: 444.90
  • Formula: C22H27ClF2O5
  • CLOGP: 2.60
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -4.10
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 2.083 Moderate 0.65
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.084 Moderate 0.65
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 31.550 10^-6 cm/s Moderate 0.65
dh-clint Dog hepatocyte intrinsic clearance 6.397 uL/min/10^6 cells Moderate 0.65
dppb Dog plasma protein binding (% unbound) 19.930 % Moderate 0.65
fcs-ppb Fetal calf serum protein binding (% unbound) 27.730 % Moderate 0.65
herg hERG pIC50 4.552 pIC50 Moderate 0.65
hh-clint Human hepatocyte intrinsic clearance 2.999 uL/min/10^6 cells Moderate 0.65
hlm-clint Human liver microsomal intrinsic clearance 9.705 uL/min/mg protein Moderate 0.65
hppb Human plasma protein binding (% unbound) 14.260 % Moderate 0.65
kinase-safety-class ACVR2B,CAMK2D,CDK5,EIF2AK3,GRK2,ITK,MAPK10,PDK1,PDK2,PDK4,PRKDC 11
kinase-selectivity-class EIF2AK3,GRK2,MAP2K6,PDK1 4
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 5.902 Moderate 0.65
mh-clint Mouse hepatocyte intrinsic clearance 25.882 Moderate 0.65
mppb Mouse plasma protein binding (% unbound) 17.150 Moderate 0.65
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 14.125 Moderate 0.65
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 22.220 % Moderate 0.65
rh-clint Rat hepatocyte intrinsic clearance 40.458 uL/min/10^6 cells Moderate 0.65
rh-fuinc Rat hepatocyte fraction unbound in incubation 68.680 % Moderate 0.65
rppb Rat plasma protein binding (% unbound) 13.200 % Moderate 0.65
solubility-dd Solubility at pH 7.4 in DMSO 378.443 uM Moderate 0.65

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AC12 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D003879 Dermatologic Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones

Related Drugs by ATC class:

D07AC Corticosteroids, potent (group III) 20 drugs
amcinonidebeclometasone dipropionatebetamethasonebudesonidedesoximetasonediflorasone diacetatediflucortolonedifluprednatefluclorolonefludroxycortidefluocinolone acetonidefluocinonide show all 20 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.78 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07202 KEGG_DRUG
C0062097 UMLSCUI
CHEBI:135724 CHEBI
CHEMBL1587228 ChEMBL_ID
DB13728 DRUGBANK_ID
C036518 MESH_SUPPLEMENTAL_RECORD_UI
4647 INN_ID
J69Z9UU41Z UNII
9846332 PUBCHEM_CID
26416 RXNORM
006912 NDDF
704673003 SNOMEDCT_US
715413003 SNOMEDCT_US
J69Z9UU41Z INXIGHT DRUGS

Pharmaceutical products:

None