Drug results: 49
| talbutal |
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| barbital | A long-acting barbiturate that depresses most metabolic processes at high doses. It is used as a hypnotic and sedative and may induce dependence. Barbital is also used in veterinary practice for central nervous system depression. |
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| hexobarbital | A barbiturate that is effective as a hypnotic and sedative. |
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| phenobarbital | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. |
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| secobarbital | A barbiturate that is used as a sedative. Secobarbital is reported to have no anti-anxiety activity. |
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| thiopental | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. |
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| pentobarbital | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236) |
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| amobarbital | A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565) |
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| methylphenobarbital | A barbiturate that is metabolized to PHENOBARBITAL. It has been used for similar purposes, especially in EPILEPSY, but there is no evidence mephobarbital offers any advantage over PHENOBARBITAL. |
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| etallobarbital |
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| phetharbital |
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| eterobarb |
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| cyclopentobarbital |
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| vinbarbital |
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| heptobarbital |
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| aprobarbital |
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| allobarbital |
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| butalbital | management of butalbital withdrawal can be simplified by using a phenobarbital-loading protocol; RN given refers to parent cpd |
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| bucolome |
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| reposal |
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| nikethamide | A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229) |
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| thialbarbital |
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| primidone | A barbiturate derivative that acts as a GABA modulator and anti-epileptic agent. It is partly metabolized to PHENOBARBITAL in the body and owes some of its actions to this metabolite. |
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| secbutabarbital | Butabarbital (a synonym for Secbutabarbital) should be distinguished from Butobarbital |
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| metharbital |
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| methohexital | An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia. |
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| butobarbital | Butobarbital should be distinguished from Butabarbital (a synonym for Secbutabarbital) |
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| thiamylal | A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919) |
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| stiripentol | In animal models, stiripentol antagonizes seizures induced by electric shock, pentetrazole and bicuculline. In rodent models, stiripentol appears to increase brain levels of gamma-aminobutyric acid (GABA) - the major inhibitory neurotransmitter in mammalian brain. This could occur by inhibition of synaptosomal uptake of GABA and/or inhibition of GABA transaminase. Stiripentol has also been shown to enhance GABAA receptor-mediated transmission in the immature rat hippocampus and increase the mean open-duration (but not the frequency) of GABAA receptor chloride channels by a barbiturate-like mechanism. Stiripentol potentiates the efficacy of other anticonvulsants, such as carbamazepine, sodium valproate, phenytoin, phenobarbital and many benzodiazepines, as the result of pharmacokinetic interactions. The second effect of stiripentol is mainly based on metabolic inhibition of several isoenzymes, in particular CYP450 3A4 and 2C19, involved in the hepatic metabolism of other anti-epileptic medicines. |
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| proxibarbal |
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| cyclobarbital |
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| propallylonal |
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| methitural |
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| vinylbital |
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| brallobarbital |
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| difebarbamate |
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| febarbamate |
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| carbubarb |
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| heptabarb |
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| barbexaclone | ||
| thalidomide | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action. |
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| bemegride | A CNS stimulant that is used to induce convulsions in experimental animals. It has also been used as a respiratory stimulant and in the treatment of barbiturate overdose. |
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| amiphenazole | used as a respiratory tonic, morphine antagonist, & antidote in barbiturate poisoning; RN given refers to parent cpd; sturcture |
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| narcobarbital |
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| picrotoxin | A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. | |
| tetrabarbital |
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| enallylpropymal |
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| nealbarbital |
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| buthalital |
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