nikethamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 3383 59-26-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nikethamide
  • anacardone
  • anacordone
  • niamine
  • nicamide
  • nicetamide
  • nicethamide
  • nicorine
  • nicotinic acid diethylamide
  • carbamidal
  • pyricardyl
A central nervous system stimulant. It was formerly used in the treatment of barbiturate overdose but is now considered to be of no value for such purposes and may be dangerous. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1229)
  • Molecular weight: 178.24
  • Formula: C10H14N2O
  • CLOGP: 0.56
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 33.20
  • ALOGS: -0.21
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.50 g O
0.50 g P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R07AB02 RESPIRATORY SYSTEM
OTHER RESPIRATORY SYSTEM PRODUCTS
OTHER RESPIRATORY SYSTEM PRODUCTS
Respiratory stimulants
ATC R07AB52 RESPIRATORY SYSTEM
OTHER RESPIRATORY SYSTEM PRODUCTS
OTHER RESPIRATORY SYSTEM PRODUCTS
Respiratory stimulants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D003292 Convulsants

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167328 NUI
D07408 KEGG_DRUG
C0028089 UMLSCUI
CHEBI:134814 CHEBI
CHEMBL2104607 ChEMBL_ID
DB13655 DRUGBANK_ID
D009552 MESH_DESCRIPTOR_UI
5497 PUBCHEM_CID
403 INN_ID
368IVD6M32 UNII
7424 RXNORM
001381 NDDF
387591002 SNOMEDCT_US
9690006 SNOMEDCT_US

Pharmaceutical products:

None