metharbital 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
hypnotics, barbituric acid derivatives	1740	50-11-3

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

metharbital
metabarbital
methabarbitone
metharbitone
methylbarbital
N-Methylbarbital

Molecular weight: 198.22
Formula: C9H14N2O3
CLOGP: 1.14
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 66.48
ALOGS: -1.01
ROTB: 2

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA	ABBVIE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N03AA30	NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Barbiturates and derivatives

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Epilepsy	indication	84757009	DOID:1826
Insomnia	indication	193462001
Tonic-clonic epilepsy	indication	352818000	DOID:7725

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.43	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN	POSITIVE ALLOSTERIC MODULATOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018729	VUID
N0000147034	NUI
D01382	KEGG_DRUG
4018729	VANDF
C0025629	UMLSCUI
CHEBI:31827	CHEBI
VOK	PDB_CHEM_ID
CHEMBL450	ChEMBL_ID
DB00463	DRUGBANK_ID
4099	PUBCHEM_CID
2	INN_ID
C084822	MESH_SUPPLEMENTAL_RECORD_UI
7230	IUPHAR_LIGAND_ID
02OS7K758T	UNII
6825	RXNORM
001419	NDDF
30676006	SNOMEDCT_US

Pharmaceutical products:

None