hydroxychloroquine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 1395 118-42-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydroxychloroquine
  • hydroxychloroquine sulfate
  • oxichloroquine
  • oxychlorochin
  • oxychloroquine
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
  • Molecular weight: 335.88
  • Formula: C18H26ClN3O
  • CLOGP: 4.12
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 48.39
  • ALOGS: -4.11
  • ROTB: 9

Drug dosage:

DoseUnitRoute
0.52 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 200 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 27 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 29.77 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 700 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.57 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 850 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 18, 1955 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 21821.90 42.70 5901 6318 95723 2250143
Rheumatoid arthritis 15672.61 42.70 3363 8856 15777 2330089
Drug intolerance 9154.98 42.70 2061 10158 11656 2334210
Joint swelling 5708.54 42.70 1472 10747 15347 2330519
Treatment failure 5479.59 42.70 1214 11005 6025 2339841
Contraindicated product administered 4977.68 42.70 967 11252 2054 2343812
Synovitis 4863.64 42.70 933 11286 1793 2344073
Pain 4053.81 42.70 1536 10683 60321 2285545
Arthralgia 3565.31 42.70 1353 10866 52932 2292934
Drug hypersensitivity 3523.07 42.70 1289 10930 45354 2300512
Therapeutic product effect decreased 3061.24 42.70 824 11395 9965 2335901
Abdominal discomfort 2914.07 42.70 881 11338 16575 2329291
Condition aggravated 2841.98 42.70 1000 11219 30979 2314887
Therapeutic product effect incomplete 2634.40 42.70 729 11490 9802 2336064
Arthropathy 2556.44 42.70 660 11559 6656 2339210
Rash 2322.83 42.70 1026 11193 58532 2287334
Fatigue 2224.26 42.70 1110 11109 83763 2262103
C-reactive protein abnormal 2181.97 42.70 393 11826 406 2345460
Nausea 2164.01 42.70 1194 11025 110995 2234871
Pemphigus 2060.08 42.70 365 11854 311 2345555
Peripheral swelling 2008.26 42.70 666 11553 16931 2328935
Alopecia 2000.33 42.70 702 11517 21299 2324567
Loss of personal independence in daily activities 1949.62 42.70 499 11720 4812 2341054
Systemic lupus erythematosus 1915.03 42.70 470 11749 3751 2342115
Red blood cell sedimentation rate abnormal 1777.83 42.70 310 11909 213 2345653
Swelling 1721.90 42.70 583 11636 15767 2330099
Musculoskeletal stiffness 1529.29 42.70 497 11722 11750 2334116
Rheumatoid factor positive 1410.94 42.70 254 11965 258 2345608
Infection 1337.38 42.70 496 11723 17533 2328333
C-reactive protein increased 1314.17 42.70 379 11840 5876 2339990
Hepatic enzyme increased 1264.14 42.70 408 11811 9394 2336472
Hand deformity 1261.13 42.70 261 11958 825 2345041
Diarrhoea 1112.65 42.70 705 11514 82859 2263007
Glossodynia 1062.48 42.70 252 11967 1693 2344173
Mobility decreased 1059.48 42.70 348 11871 8462 2337404
Pain in extremity 1017.17 42.70 527 11692 42013 2303853
Off label use 1013.68 42.70 635 11584 72963 2272903
Headache 988.40 42.70 645 11574 79534 2266332
Vomiting 950.99 42.70 604 11615 70998 2274868
Arthritis 908.82 42.70 320 11899 9648 2336218
Red blood cell sedimentation rate increased 896.98 42.70 224 11995 1913 2343953
Hypersensitivity 851.43 42.70 388 11831 23205 2322661
Knee arthroplasty 812.42 42.70 221 11998 2714 2343152
Anti-cyclic citrullinated peptide antibody positive 809.33 42.70 138 12081 65 2345801
Musculoskeletal pain 808.57 42.70 300 11919 10530 2335336
Osteoarthritis 776.92 42.70 260 11959 6686 2339180
Malaise 751.36 42.70 475 11744 55110 2290756
Gastrointestinal disorder 739.55 42.70 267 11952 8650 2337216
Gait disturbance 738.94 42.70 347 11872 22198 2323668
Retinal toxicity 729.95 42.70 126 12093 73 2345793
Bone erosion 703.28 42.70 144 12075 422 2345444
Therapeutic response decreased 678.28 42.70 237 11982 6958 2338908
Eye disorder 665.76 42.70 193 12026 3026 2342840
Herpes zoster 658.73 42.70 251 11968 9474 2336392
Adverse drug reaction 619.81 42.70 230 11989 8053 2337813
Blood iron abnormal 616.67 42.70 107 12112 67 2345799
Weight decreased 614.92 42.70 330 11889 28041 2317825
Fibromyalgia 604.00 42.70 180 12039 3120 2342746
Inflammation 590.63 42.70 206 12013 6007 2339859
Impaired work ability 584.35 42.70 154 12065 1656 2344210
Interstitial lung disease 577.40 42.70 215 12004 7597 2338269
Pneumonia 566.40 42.70 381 11838 48915 2296951
Hip arthroplasty 553.77 42.70 149 12070 1745 2344121
Musculoskeletal disorder 537.86 42.70 155 12064 2373 2343493
Rheumatoid nodule 514.53 42.70 113 12106 505 2345361
Liver function test increased 510.87 42.70 156 12063 2945 2342921
Disability 502.18 42.70 117 12102 715 2345151
Psoriatic arthropathy 499.44 42.70 162 12057 3752 2342114
Osteoporosis 492.20 42.70 165 12054 4249 2341617
Sinusitis 478.71 42.70 234 11985 16292 2329574
Leukopenia 477.99 42.70 202 12017 9994 2335872
Deafness transitory 472.47 42.70 86 12133 97 2345769
Pharyngitis 470.81 42.70 136 12083 2099 2343767
Joint stiffness 466.91 42.70 155 12064 3868 2341998
Shoulder arthroplasty 464.53 42.70 96 12123 298 2345568
Ear infection 461.78 42.70 148 12071 3293 2342573
Toxicity to various agents 448.60 42.70 283 11936 32471 2313395
Joint range of motion decreased 440.67 42.70 124 12095 1732 2344134
Neck pain 437.21 42.70 175 12044 7522 2338344
Sleep disorder 433.67 42.70 166 12053 6323 2339543
Spinal stenosis 425.98 42.70 114 12105 1304 2344562
Dizziness 421.57 42.70 342 11877 58323 2287543
Gastrointestinal pain 414.53 42.70 106 12113 1000 2344866
Glaucoma 403.78 42.70 119 12100 1976 2343890
Sciatica 397.75 42.70 118 12101 2007 2343859
Maternal exposure during pregnancy 396.28 42.70 199 12020 14664 2331202
Mouth ulceration 395.86 42.70 136 12083 3776 2342090
Grip strength decreased 394.65 42.70 101 12118 956 2344910
Pulmonary fibrosis 393.34 42.70 123 12096 2517 2343349
Abdominal pain upper 382.36 42.70 222 11997 21878 2323988
Visual impairment 381.29 42.70 180 12039 11575 2334291
Drug eruption 379.83 42.70 126 12093 3133 2342733
Retinopathy 367.49 42.70 85 12134 500 2345366
Anaphylactic reaction 362.75 42.70 164 12055 9541 2336325
Adverse event 356.30 42.70 151 12068 7508 2338358
Adverse reaction 354.17 42.70 101 12118 1483 2344383
Pneumonia viral 352.32 42.70 79 12140 395 2345471
Diverticulitis 345.81 42.70 125 12094 4040 2341826
Non-Hodgkin's lymphoma 344.38 42.70 88 12131 827 2345039
Bronchitis 337.48 42.70 174 12045 13540 2332326
Product use issue 336.26 42.70 167 12052 12002 2333864
Liver function test abnormal 329.66 42.70 142 12077 7348 2338518
Colitis microscopic 327.79 42.70 85 12134 851 2345015
Granuloma skin 312.29 42.70 57 12162 66 2345800
Infusion related reaction 311.43 42.70 148 12071 9648 2336218
Hepatotoxicity 309.79 42.70 110 12109 3371 2342495
Wound 308.01 42.70 103 12116 2625 2343241
Nodule 303.70 42.70 97 12122 2129 2343737
Asthenia 302.03 42.70 257 11962 46669 2299197
Loss of consciousness 302.02 42.70 180 12039 18587 2327279
Deformity 295.14 42.70 69 12150 428 2345438
Fall 286.94 42.70 250 11969 46849 2299017
Blood parathyroid hormone decreased 284.60 42.70 58 12161 164 2345702
Lung disorder 283.97 42.70 121 12098 6091 2339775
Coeliac disease 283.81 42.70 74 12145 758 2345108
Pruritus 282.17 42.70 239 11980 43101 2302765
Cardiomyopathy 281.62 42.70 97 12122 2710 2343156
Ill-defined disorder 278.95 42.70 101 12118 3277 2342589
Femur fracture 277.72 42.70 122 12097 6617 2339249
Exposure during pregnancy 276.81 42.70 190 12029 25029 2320837
Urticaria 276.29 42.70 187 12032 24074 2321792
Blood cholesterol increased 276.24 42.70 113 12106 5128 2340738
Dyspnoea 274.56 42.70 308 11911 78425 2267441
Joint injury 271.57 42.70 91 12128 2333 2343533
Finger deformity 268.54 42.70 71 12148 771 2345095
Pulmonary mass 267.15 42.70 85 12134 1841 2344025
Deafness 265.79 42.70 92 12127 2609 2343257
Injection site reaction 264.82 42.70 153 12066 14899 2330967
Decreased appetite 264.80 42.70 195 12024 28696 2317170
Hypertension 258.26 42.70 188 12031 27173 2318693
Foot operation 256.97 42.70 67 12152 686 2345180
Nail disorder 256.46 42.70 73 12146 1063 2344803
Nasopharyngitis 255.87 42.70 172 12047 21884 2323982
Onychomycosis 250.47 42.70 62 12157 505 2345361
Panniculitis 248.96 42.70 61 12158 474 2345392
Back pain 248.91 42.70 195 12024 31464 2314402
Pyrexia 247.48 42.70 244 11975 53464 2292402
Therapy non-responder 247.05 42.70 119 12100 7985 2337881
Gait inability 239.52 42.70 106 12113 5849 2340017
Joint effusion 239.33 42.70 71 12148 1205 2344661
Fine motor skill dysfunction 235.98 42.70 53 12166 267 2345599
Hepatitis 226.89 42.70 104 12115 6233 2339633
Rash pruritic 224.70 42.70 109 12110 7426 2338440
Stomatitis 223.83 42.70 118 12101 9592 2336274
Oral mucosal exfoliation 223.73 42.70 48 12171 187 2345679
Hypophagia 223.65 42.70 90 12129 3910 2341956
Arthrodesis 220.12 42.70 47 12172 178 2345688
Elbow deformity 216.10 42.70 39 12180 40 2345826
Soft tissue disorder 215.37 42.70 47 12172 202 2345664
Cough 214.01 42.70 182 12037 32935 2312931
International normalised ratio fluctuation 212.68 42.70 49 12170 282 2345584
Tenosynovitis 210.79 42.70 53 12166 463 2345403
Epicondylitis 205.59 42.70 46 12173 227 2345639
Cutaneous vasculitis 205.52 42.70 48 12171 296 2345570
Product use in unapproved indication 202.65 42.70 116 12103 11084 2334782
Skin lesion 199.23 42.70 83 12136 3942 2341924
Abdominal pain 198.10 42.70 177 12042 34197 2311669
Lower respiratory tract infection 197.25 42.70 90 12129 5334 2340532
Skin necrosis 195.10 42.70 59 12160 1072 2344794
Osteopenia 194.57 42.70 67 12152 1868 2343998
Cataract 192.97 42.70 91 12128 5817 2340049
Skin ulcer 191.86 42.70 81 12138 3978 2341888
Body height below normal 191.19 42.70 37 12182 72 2345794
Alanine aminotransferase increased 190.90 42.70 121 12098 13911 2331955
Maculopathy 189.28 42.70 47 12172 388 2345478
Dyspepsia 188.99 42.70 106 12113 9738 2336128
Depression 186.59 42.70 157 12062 27975 2317891
Presbyacusis 186.41 42.70 33 12186 27 2345839
Secretion discharge 185.32 42.70 58 12161 1187 2344679
Human antichimeric antibody positive 184.22 42.70 31 12188 11 2345855
Visual field defect 182.09 42.70 60 12159 1456 2344410
Dry eye 180.52 42.70 77 12142 3879 2341987
Joint destruction 180.27 42.70 43 12176 294 2345572
Hypercalcaemia 179.06 42.70 68 12151 2524 2343342
Septic shock 177.65 42.70 91 12128 6963 2338903
Feeding disorder 176.31 42.70 58 12161 1400 2344466
Polyarthritis 174.15 42.70 51 12168 825 2345041
Urinary tract infection 170.12 42.70 153 12066 29789 2316077
Ulcer 169.44 42.70 60 12159 1820 2344046
SLE arthritis 167.91 42.70 32 12187 55 2345811
Tuberculin test positive 165.08 42.70 45 12174 553 2345313
Tenderness 164.49 42.70 59 12160 1859 2344007
Aspartate aminotransferase increased 162.22 42.70 105 12114 12507 2333359
Erythema 159.80 42.70 137 12082 25022 2320844
Bone density decreased 159.65 42.70 53 12166 1317 2344549
Diabetes mellitus 158.39 42.70 86 12133 7409 2338457
Pain in jaw 156.97 42.70 81 12138 6291 2339575
Pustular psoriasis 156.27 42.70 47 12172 837 2345029
Deafness neurosensory 155.36 42.70 42 12177 499 2345367
Fear of injection 154.58 42.70 47 12172 870 2344996
Adrenal insufficiency 154.56 42.70 52 12167 1348 2344518
Carpal tunnel syndrome 153.97 42.70 57 12162 1968 2343898
X-ray abnormal 153.91 42.70 33 12186 128 2345738
Bone disorder 153.26 42.70 65 12154 3227 2342639
Hypokalaemia 152.72 42.70 95 12124 10559 2335307
Joint laxity 152.65 42.70 28 12191 34 2345832
Basal cell carcinoma 152.04 42.70 61 12158 2626 2343240
Bronchitis chronic 148.52 42.70 39 12180 411 2345455
Back injury 148.47 42.70 46 12173 909 2344957
Breast cancer stage III 147.67 42.70 32 12187 132 2345734
Unevaluable event 147.31 42.70 87 12132 8804 2337062
Neck mass 146.55 42.70 37 12182 329 2345537
Contusion 146.21 42.70 99 12120 12711 2333155
Impaired healing 145.55 42.70 73 12146 5338 2340528
Pulmonary toxicity 145.31 42.70 42 12177 647 2345219
Crohn's disease 145.18 42.70 78 12141 6577 2339289
Surgical failure 143.00 42.70 30 12189 102 2345764
Pleural fibrosis 141.19 42.70 32 12187 169 2345697
Drug tolerance decreased 140.86 42.70 34 12185 246 2345620
Blood pressure increased 140.60 42.70 108 12111 16878 2328988
Foot deformity 140.33 42.70 53 12166 1936 2343930
Onychomadesis 139.61 42.70 38 12181 464 2345402
Obesity 138.34 42.70 49 12170 1487 2344379
Discomfort 137.00 42.70 69 12150 5090 2340776
Hepatic steatosis 134.97 42.70 59 12160 3154 2342712
Intentional product use issue 134.82 42.70 61 12158 3541 2342325
Chest pain 133.27 42.70 130 12089 28007 2317859
Neutropenia 132.05 42.70 115 12104 21433 2324433
Blood creatinine increased 131.28 42.70 86 12133 10447 2335419
Lupus nephritis 131.15 42.70 33 12186 289 2345577
Torsade de pointes 130.58 42.70 52 12167 2194 2343672
Pleural thickening 130.44 42.70 26 12193 63 2345803
Loose body in joint 130.02 42.70 24 12195 31 2345835
Gastric disorder 129.96 42.70 60 12159 3650 2342216
Neoplasm malignant 129.07 42.70 66 12153 5027 2340839
Juvenile idiopathic arthritis 128.24 42.70 35 12184 432 2345434
Drug-induced liver injury 127.01 42.70 59 12160 3640 2342226
Myopathy 126.82 42.70 46 12173 1497 2344369
Neck deformity 126.49 42.70 25 12194 57 2345809
Thyroid disorder 125.95 42.70 46 12173 1527 2344339
Bone density abnormal 121.91 42.70 33 12186 394 2345472
Localised infection 121.42 42.70 53 12166 2823 2343043
Sjogren's syndrome 120.97 42.70 40 12179 981 2344885
Iron deficiency anaemia 119.95 42.70 48 12171 2051 2343815
Acute generalised exanthematous pustulosis 119.94 42.70 45 12174 1613 2344253
Joint arthroplasty 119.47 42.70 32 12187 366 2345500
Proteinuria 118.63 42.70 52 12167 2798 2343068
Hypoaesthesia 118.07 42.70 105 12114 20110 2325756
Liver disorder 117.47 42.70 67 12152 6347 2339519
Osteoporotic fracture 117.42 42.70 31 12188 334 2345532
Oral pain 116.06 42.70 54 12165 3343 2342523
Anaemia 115.40 42.70 133 12086 34659 2311207
Wheelchair user 115.02 42.70 32 12187 426 2345440
Helicobacter infection 114.73 42.70 34 12185 574 2345292
Drug interaction 113.10 42.70 121 12098 29042 2316824
Insomnia 112.57 42.70 114 12105 25673 2320193
Disease recurrence 112.17 42.70 53 12166 3398 2342468
Extremity contracture 111.74 42.70 24 12195 94 2345772
Transaminases abnormal 111.54 42.70 24 12195 95 2345771
Myocardial infarction 111.52 42.70 99 12120 18914 2326952
Cushingoid 110.27 42.70 33 12186 577 2345289
Antibody test positive 109.05 42.70 28 12191 268 2345598
Spinal column injury 108.28 42.70 27 12192 227 2345639
Electrocardiogram QT prolonged 107.73 42.70 68 12151 7746 2338120
Stress 107.39 42.70 65 12154 6873 2338993
Premature delivery 106.63 42.70 50 12169 3150 2342716
Multiple allergies 106.55 42.70 35 12184 840 2345026
Psoriasis 104.63 42.70 91 12128 16917 2328949
Pneumonitis 104.25 42.70 53 12166 3986 2341880
Ovarian neoplasm 103.79 42.70 25 12194 179 2345687
Red blood cell sedimentation rate 103.23 42.70 18 12201 12 2345854
Breast cancer 102.67 42.70 71 12148 9424 2336442
Renal impairment 101.07 42.70 72 12147 10020 2335846
Musculoskeletal deformity 100.46 42.70 18 12201 17 2345849
General physical health deterioration 100.02 42.70 82 12137 14057 2331809
Drug dependence 99.68 42.70 47 12172 2998 2342868
Investigation abnormal 99.51 42.70 21 12198 74 2345792
Syncope 99.21 42.70 88 12131 16787 2329079
Upper limb fracture 98.37 42.70 45 12174 2678 2343188
Retinal degeneration 97.75 42.70 23 12196 147 2345719
Seronegative arthritis 97.73 42.70 20 12199 58 2345808
Functional gastrointestinal disorder 96.22 42.70 28 12191 442 2345424
Platelet count decreased 96.04 42.70 84 12135 15729 2330137
Dermatitis allergic 93.80 42.70 40 12179 2011 2343855
Rash maculo-papular 93.17 42.70 50 12169 4202 2341664
Blood magnesium increased 92.27 42.70 22 12197 150 2345716
Bronchiectasis 91.66 42.70 32 12187 929 2344937
Hypotension 91.13 42.70 114 12105 32322 2313544
Cardiotoxicity 90.76 42.70 34 12185 1213 2344653
Somnolence 90.24 42.70 97 12122 23388 2322478
Respiratory tract infection 90.03 42.70 48 12171 3981 2341885
Ocular toxicity 89.82 42.70 20 12199 96 2345770
Influenza like illness 89.35 42.70 72 12147 12042 2333824
Crying 88.85 42.70 49 12170 4347 2341519
Skin reaction 88.20 42.70 38 12181 1959 2343907
Myopathy toxic 87.55 42.70 19 12200 79 2345787
Epigastric discomfort 87.44 42.70 27 12192 527 2345339
Oral disorder 86.44 42.70 34 12185 1387 2344479
Joint dislocation 85.64 42.70 34 12185 1422 2344444
Ankle arthroplasty 85.63 42.70 17 12202 40 2345826
Ejection fraction decreased 84.88 42.70 41 12178 2760 2343106
Nephrolithiasis 84.63 42.70 48 12171 4495 2341371
Limb operation 82.82 42.70 26 12193 537 2345329
Lyme disease 81.71 42.70 24 12195 392 2345474
Mycobacterial infection 81.55 42.70 22 12197 259 2345607
Vision blurred 81.29 42.70 74 12145 14594 2331272
Phospholipidosis 81.11 42.70 14 12205 8 2345858
Oedema peripheral 80.68 42.70 92 12127 23671 2322195
Viral upper respiratory tract infection 80.49 42.70 30 12189 1055 2344811
Physical disability 80.32 42.70 20 12199 167 2345699
Photophobia 80.09 42.70 37 12182 2252 2343614
Mesenteritis 79.89 42.70 14 12205 10 2345856
Angioedema 79.71 42.70 58 12161 8338 2337528
Drug specific antibody 79.47 42.70 17 12202 65 2345801
Dislocation of vertebra 79.42 42.70 18 12201 95 2345771
Accident 79.33 42.70 28 12191 840 2345026
Rheumatoid factor negative 79.32 42.70 14 12205 11 2345855
Retinitis 78.86 42.70 17 12202 68 2345798
Thrombocytopenia 78.77 42.70 82 12137 19049 2326817
Muscular weakness 78.37 42.70 73 12146 14824 2331042
Candida infection 77.94 42.70 39 12180 2834 2343032
Disease susceptibility 77.90 42.70 15 12204 28 2345838
Limb discomfort 77.60 42.70 41 12178 3338 2342528
Anxiety 77.41 42.70 100 12119 29259 2316607
Eye haemorrhage 77.29 42.70 31 12188 1332 2344534
Encephalitis 77.21 42.70 30 12189 1184 2344682
Immobile 76.74 42.70 25 12194 584 2345282
White blood cell count decreased 76.69 42.70 79 12140 18129 2327737
Pancytopenia 75.95 42.70 64 12155 11388 2334478
Wrist deformity 75.94 42.70 17 12202 84 2345782
Palpitations 75.90 42.70 75 12144 16381 2329485
Treatment noncompliance 75.87 42.70 48 12171 5486 2340380
Retinal disorder 75.79 42.70 22 12197 344 2345522
Lymphopenia 74.59 42.70 36 12183 2418 2343448
Incorrect dosage administered 74.47 42.70 22 12197 367 2345499
Wrist surgery 74.47 42.70 18 12201 131 2345735
Laryngeal disorder 74.34 42.70 17 12202 94 2345772
Pericarditis 73.63 42.70 31 12188 1509 2344357
Immunodeficiency 73.46 42.70 28 12191 1048 2344818
Weight increased 73.33 42.70 85 12134 22252 2323614
Rash pustular 73.11 42.70 31 12188 1536 2344330
Cyst 72.62 42.70 31 12188 1562 2344304
Overdose 72.57 42.70 80 12139 19827 2326039
Muscle spasms 72.36 42.70 83 12136 21483 2324383
Bone cyst 71.29 42.70 18 12201 160 2345706
Scar 70.25 42.70 32 12187 1885 2343981
Inflammatory marker increased 70.05 42.70 23 12196 551 2345315
Bloody discharge 69.36 42.70 17 12202 132 2345734
Drug reaction with eosinophilia and systemic symptoms 68.58 42.70 45 12174 5473 2340393
Intervertebral disc space narrowing 68.16 42.70 16 12203 101 2345765
Gingival bleeding 68.12 42.70 32 12187 2023 2343843
Restrictive cardiomyopathy 68.07 42.70 15 12204 68 2345798
Visual acuity reduced 67.79 42.70 44 12175 5254 2340612
Anterior chamber cleavage syndrome 67.68 42.70 12 12207 10 2345856
Bursitis 67.25 42.70 31 12188 1877 2343989
Blister 67.06 42.70 48 12171 6723 2339143
Sleep disorder due to general medical condition, insomnia type 66.65 42.70 20 12199 353 2345513
Abdominal distension 66.61 42.70 57 12162 10354 2335512
Skin papilloma 65.78 42.70 22 12197 559 2345307
Osteomyelitis 63.96 42.70 37 12182 3596 2342270
Groin pain 63.96 42.70 27 12192 1323 2344543
Myalgia 63.89 42.70 81 12138 23252 2322614
Tuberculosis 63.74 42.70 30 12189 1905 2343961
Nasal congestion 63.58 42.70 47 12172 6919 2338947
Foetal exposure during pregnancy 63.25 42.70 42 12177 5210 2340656
Tooth infection 63.25 42.70 30 12189 1938 2343928
Multiple fractures 63.20 42.70 22 12197 633 2345233
Rash erythematous 62.97 42.70 44 12175 5932 2339934
Intervertebral disc compression 62.79 42.70 16 12203 148 2345718
Night sweats 62.56 42.70 36 12183 3464 2342402
Lymphadenopathy 62.50 42.70 43 12176 5655 2340211
Intervertebral disc protrusion 61.73 42.70 34 12185 3007 2342859
Blood pressure fluctuation 61.54 42.70 29 12190 1846 2344020
Migraine 61.48 42.70 55 12164 10598 2335268
Vasculitic rash 61.23 42.70 16 12203 165 2345701
Lip ulceration 60.84 42.70 17 12202 230 2345636
Synovial cyst 60.69 42.70 23 12196 847 2345019
Premature baby 60.07 42.70 34 12185 3170 2342696
Dyspnoea exertional 60.00 42.70 42 12177 5678 2340188
Spinal disorder 60.00 42.70 25 12194 1185 2344681
Pharyngeal oedema 59.97 42.70 35 12184 3458 2342408
Hypoglycaemia 59.93 42.70 49 12170 8358 2337508
Macular degeneration 59.74 42.70 25 12194 1198 2344668
Mood swings 59.43 42.70 34 12185 3235 2342631
Intervertebral disc degeneration 59.40 42.70 27 12192 1582 2344284
Osteosclerosis 59.39 42.70 18 12201 329 2345537
Limb deformity 59.34 42.70 17 12202 253 2345613
Red cell distribution width decreased 59.16 42.70 13 12206 58 2345808
Thyroid neoplasm 59.09 42.70 21 12198 643 2345223
Burning sensation 58.71 42.70 47 12172 7781 2338085
Electrocardiogram U-wave abnormality 58.43 42.70 11 12208 17 2345849
Wound infection 58.40 42.70 25 12194 1268 2344598
Histoplasmosis disseminated 57.99 42.70 16 12203 206 2345660
Toxic epidermal necrolysis 57.96 42.70 33 12186 3111 2342755
Pyelonephritis 57.89 42.70 29 12190 2112 2343754
Intraocular pressure increased 57.86 42.70 26 12193 1483 2344383
Gastrointestinal toxicity 57.76 42.70 20 12199 566 2345300
Erythema multiforme 57.45 42.70 29 12190 2146 2343720
Mean platelet volume decreased 57.43 42.70 14 12205 106 2345760
Cardiac failure 57.39 42.70 56 12163 12038 2333828
Pleural effusion 57.19 42.70 55 12164 11613 2334253
Progressive multifocal leukoencephalopathy 56.99 42.70 29 12190 2183 2343683
Tinnitus 56.90 42.70 39 12180 5096 2340770
Neuropathy peripheral 56.25 42.70 54 12165 11378 2334488
Rheumatoid lung 56.20 42.70 15 12204 169 2345697
Back disorder 56.06 42.70 26 12193 1596 2344270
Chills 55.81 42.70 62 12157 15490 2330376
Hypertrophic cardiomyopathy 55.61 42.70 16 12203 242 2345624
Haematocrit decreased 55.58 42.70 36 12183 4282 2341584
C-reactive protein 55.37 42.70 11 12208 26 2345840
Live birth 55.16 42.70 24 12195 1267 2344599
Intentional overdose 54.80 42.70 53 12166 11268 2334598
Abnormal loss of weight 54.71 42.70 20 12199 665 2345201
Photosensitivity reaction 54.45 42.70 29 12190 2398 2343468
Infiltration anaesthesia 54.40 42.70 9 12210 2 2345864
Cardiac arrest 54.40 42.70 60 12159 14870 2330996
Injury 53.95 42.70 40 12179 5914 2339952
Retinal depigmentation 53.65 42.70 12 12207 59 2345807
Cystitis 53.59 42.70 39 12180 5603 2340263
Sepsis 53.50 42.70 66 12153 18422 2327444
Endodontic procedure 53.39 42.70 18 12201 469 2345397
Cutaneous lupus erythematosus 52.96 42.70 19 12200 598 2345268
Quality of life decreased 52.87 42.70 20 12199 733 2345133
Immune system disorder 52.87 42.70 24 12195 1402 2344464
Cystoid macular oedema 52.34 42.70 17 12202 393 2345473
Rhinorrhoea 51.96 42.70 43 12176 7457 2338409
Rebound effect 51.74 42.70 19 12200 640 2345226
Monocyte count increased 51.50 42.70 18 12201 524 2345342
Ventricular fibrillation 51.36 42.70 27 12192 2174 2343692
Mean cell volume decreased 51.12 42.70 15 12204 244 2345622
Urosepsis 51.12 42.70 26 12193 1955 2343911
Feeling abnormal 51.01 42.70 73 12146 23508 2322358
Vascular access complication 50.95 42.70 13 12206 121 2345745
Toxic skin eruption 50.69 42.70 27 12192 2233 2343633
Gastrooesophageal reflux disease 50.59 42.70 46 12173 9049 2336817
Exostosis 50.48 42.70 23 12196 1355 2344511
Eating disorder 50.46 42.70 27 12192 2254 2343612
Rotator cuff syndrome 50.16 42.70 25 12194 1800 2344066
Hepatitis B reactivation 49.97 42.70 15 12204 265 2345601
Oedema 49.83 42.70 48 12171 10155 2335711
Completed suicide 49.80 42.70 68 12151 20966 2324900
Disease progression 49.42 42.70 61 12158 17034 2328832
Musculoskeletal discomfort 49.25 42.70 26 12193 2112 2343754
Night blindness 49.07 42.70 13 12206 142 2345724
Red blood cell count decreased 48.69 42.70 33 12186 4233 2341633
Type 2 diabetes mellitus 48.62 42.70 26 12193 2168 2343698
Blood potassium increased 48.59 42.70 26 12193 2170 2343696
Anaphylactic shock 48.55 42.70 33 12186 4253 2341613
Poor quality sleep 48.39 42.70 25 12194 1942 2343924
Enthesopathy 48.11 42.70 13 12206 154 2345712
Lymphadenectomy 48.03 42.70 13 12206 155 2345711
Optical coherence tomography abnormal 47.77 42.70 9 12210 14 2345852
Temperature intolerance 47.43 42.70 20 12199 977 2344889
Haemophagocytic lymphohistiocytosis 47.27 42.70 22 12197 1361 2344505
Paraesthesia 47.22 42.70 68 12151 22020 2323846
Memory impairment 47.19 42.70 52 12167 12871 2332995
Irritable bowel syndrome 47.03 42.70 24 12195 1817 2344049
Restrictive pulmonary disease 46.93 42.70 13 12206 170 2345696
Deafness bilateral 46.92 42.70 14 12205 242 2345624
Shoulder operation 46.01 42.70 15 12204 351 2345515
Viral infection 45.96 42.70 33 12186 4643 2341223
Mean cell haemoglobin decreased 45.88 42.70 14 12205 262 2345604
Dysphagia 45.85 42.70 51 12168 12754 2333112
Electrocardiogram QRS complex prolonged 45.50 42.70 20 12199 1082 2344784
Neck surgery 44.92 42.70 13 12206 201 2345665
Systemic lupus erythematosus rash 44.86 42.70 13 12206 202 2345664
Bone swelling 44.68 42.70 13 12206 205 2345661
Laboratory test abnormal 44.51 42.70 34 12185 5256 2340610
Skin swelling 44.48 42.70 15 12204 391 2345475
Pulmonary haemosiderosis 44.42 42.70 8 12211 8 2345858
Skin warm 43.50 42.70 17 12202 681 2345185
Duodenal ulcer perforation 43.21 42.70 14 12205 321 2345545
No adverse event 43.12 42.70 43 12176 9485 2336381
Immunosuppression 42.84 42.70 19 12200 1050 2344816

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 3885.09 58.21 1105 1448 62696 1681532
Rheumatoid arthritis 2802.01 58.21 532 2021 4053 1740175
Drug intolerance 1675.76 58.21 366 2187 5696 1738532
Joint swelling 1513.98 58.21 340 2213 6013 1738215
Synovitis 962.53 58.21 165 2388 580 1743648
Treatment failure 959.15 58.21 220 2333 4181 1740047
Contraindicated product administered 853.49 58.21 165 2388 1279 1742949
Pain 757.43 58.21 271 2282 26386 1717842
Loss of personal independence in daily activities 613.14 58.21 137 2416 2262 1741966
Peripheral swelling 497.66 58.21 148 2405 7823 1736405
Therapeutic product effect decreased 477.31 58.21 136 2417 6161 1738067
Arthralgia 475.33 58.21 187 2366 23257 1720971
C-reactive protein abnormal 475.22 58.21 78 2475 189 1744039
Apparent death 473.14 58.21 79 2474 221 1744007
Condition aggravated 436.37 58.21 171 2382 20979 1723249
Mobility decreased 430.35 58.21 114 2439 3906 1740322
Diverticulitis 408.21 58.21 98 2455 2227 1742001
Drug hypersensitivity 400.70 58.21 147 2406 14988 1729240
Therapeutic product effect incomplete 400.52 58.21 115 2438 5333 1738895
Bone erosion 373.37 58.21 62 2491 165 1744063
Nausea 321.89 58.21 182 2371 51014 1693214
C-reactive protein increased 305.34 58.21 95 2458 5790 1738438
Sleep disorder due to general medical condition, insomnia type 283.76 58.21 46 2507 99 1744129
Impaired work ability 269.58 58.21 61 2492 1052 1743176
Gastrointestinal disorder 264.54 58.21 81 2472 4667 1739561
Infection 264.53 58.21 103 2450 12257 1731971
Off label use 246.54 58.21 139 2414 38432 1705796
Hand deformity 246.21 58.21 44 2509 202 1744026
Arthropathy 239.46 58.21 67 2486 2800 1741428
Mass 236.12 58.21 55 2498 1083 1743145
Renal failure 232.20 58.21 108 2445 19909 1724319
Osteoarthritis 230.41 58.21 62 2491 2234 1741994
Red blood cell sedimentation rate abnormal 226.19 58.21 36 2517 65 1744163
Pulmonary embolism 217.74 58.21 91 2462 12968 1731260
Deep vein thrombosis 213.17 58.21 83 2470 9837 1734391
Alopecia 208.78 58.21 64 2489 3689 1740539
Red blood cell sedimentation rate increased 201.42 58.21 48 2505 1045 1743183
Rheumatoid factor positive 193.14 58.21 30 2523 42 1744186
White blood cell count decreased 190.56 58.21 83 2470 13066 1731162
Basal cell carcinoma 189.02 58.21 54 2499 2429 1741799
Pain in extremity 181.44 58.21 89 2464 18383 1725845
Disability 176.26 58.21 38 2515 516 1743712
Knee arthroplasty 172.24 58.21 41 2512 887 1743341
Limb discomfort 168.99 58.21 44 2509 1388 1742840
Nodule 168.62 58.21 40 2513 852 1743376
Musculoskeletal stiffness 165.48 58.21 60 2493 5816 1738412
Herpes zoster 164.36 58.21 56 2497 4517 1739711
Drug specific antibody present 163.94 58.21 34 2519 378 1743850
Dyspnoea 163.25 58.21 120 2433 51939 1692289
Lymphoma 161.66 58.21 46 2507 2036 1742192
Joint lock 160.07 58.21 30 2523 187 1744041
Physical disability 157.42 58.21 28 2525 124 1744104
Abdominal discomfort 153.51 58.21 64 2489 9017 1735211
Hip arthroplasty 147.71 58.21 35 2518 741 1743487
Foetal exposure during pregnancy 146.33 58.21 56 2497 6303 1737925
Pulmonary thrombosis 135.36 58.21 33 2520 791 1743437
Onychoclasis 133.60 58.21 26 2527 203 1744025
Drug use disorder 126.24 58.21 28 2525 436 1743792
Rheumatoid factor negative 124.28 58.21 17 2536 0 1744228
Drug tolerance decreased 122.88 58.21 23 2530 142 1744086
Gait inability 120.04 58.21 41 2512 3322 1740906
Acne cystic 118.76 58.21 20 2533 59 1744169
Tooth loss 118.12 58.21 28 2525 593 1743635
Pneumonia 117.08 58.21 94 2459 46088 1698140
Fatigue 113.37 58.21 96 2457 50685 1693543
Drug dependence 112.67 58.21 39 2514 3288 1740940
Therapeutic response decreased 110.77 58.21 44 2509 5456 1738772
Liver function test increased 110.45 58.21 32 2521 1507 1742721
Headache 109.00 58.21 80 2473 34296 1709932
Vitamin D deficiency 107.92 58.21 25 2528 477 1743751
Bone cyst 105.21 58.21 18 2535 60 1744168
Anti-cyclic citrullinated peptide antibody positive 104.64 58.21 17 2536 37 1744191
Rash 102.73 58.21 81 2472 38612 1705616
Arthritis 102.20 58.21 38 2515 3937 1740291
Hypertension 102.07 58.21 62 2491 19386 1724842
Ill-defined disorder 99.89 58.21 31 2522 1850 1742378
Hepatic enzyme increased 99.58 58.21 43 2510 6578 1737650
Insomnia 98.76 58.21 57 2496 16219 1728009
Lymphadenopathy 97.31 58.21 37 2516 4077 1740151
Hepatic enzyme abnormal 97.19 58.21 23 2530 483 1743745
Colitis 96.74 58.21 37 2516 4143 1740085
Prerenal failure 93.57 58.21 20 2533 259 1743969
Intestinal polyp 90.79 58.21 18 2535 156 1744072
Asthenia 90.71 58.21 72 2481 34598 1709630
Premature baby 90.06 58.21 32 2521 2910 1741318
Cytology abnormal 89.92 58.21 14 2539 20 1744208
Leukopenia 89.39 58.21 43 2510 8437 1735791
Skin mass 88.37 58.21 22 2531 575 1743653
Therapy non-responder 82.26 58.21 37 2516 6229 1737999
Swelling 81.46 58.21 38 2515 6958 1737270
Interstitial lung disease 81.03 58.21 42 2511 9654 1734574
Thrombosis 78.83 58.21 38 2515 7483 1736745
Disease recurrence 78.70 58.21 28 2525 2554 1741674
Intentional product use issue 77.29 58.21 28 2525 2691 1741537
Sepsis 77.16 58.21 52 2501 19386 1724842
Terminal state 76.92 58.21 21 2532 793 1743435
Arthritis bacterial 75.91 58.21 20 2533 658 1743570
X-ray abnormal 74.42 58.21 14 2539 89 1744139
Muscular weakness 73.24 58.21 40 2513 10209 1734019
Back disorder 68.54 58.21 20 2533 964 1743264
Lymphoedema 68.25 58.21 17 2536 445 1743783
Stomatitis 68.03 58.21 31 2522 5373 1738855
Musculoskeletal pain 66.70 58.21 30 2523 5044 1739184
Skin ulcer 65.62 58.21 25 2528 2763 1741465
Bladder transitional cell carcinoma 65.32 58.21 16 2537 390 1743838
Urticaria 64.03 58.21 39 2514 12202 1732026
Diabetes mellitus 63.71 58.21 32 2521 6876 1737352
Joint arthroplasty 63.29 58.21 12 2541 80 1744148
Fracture 62.44 58.21 19 2534 1059 1743169
Immobile 61.22 58.21 15 2538 366 1743862
Medical device implantation 60.71 58.21 11 2542 55 1744173
Hepatotoxicity 59.69 58.21 24 2529 3060 1741168
Hepatic cirrhosis 59.61 58.21 23 2530 2630 1741598
Neutropenia 58.79 58.21 43 2510 18217 1726011
Neck mass 58.30 58.21 13 2540 207 1744021

Pharmacologic Action:

SourceCodeDescription
ATC P01BA02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Aminoquinolines
FDA EPC N0000175713 Antirheumatic Agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:38068 antimalarial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D004791 Enzyme Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Ovale malaria indication 19341001 DOID:12919
Vivax malaria indication 27052006 DOID:12978
Quartan malaria indication 27618009 DOID:14324
Systemic lupus erythematosus indication 55464009 DOID:9074
Falciparum malaria indication 62676009 DOID:14067
Rheumatoid arthritis indication 69896004 DOID:7148
Discoid lupus erythematosus indication 200938002
Plasmodium Malariae Malaria Prevention indication
Plasmodium Ovale Malaria Prevention indication
Malaria Prevention indication
Plasmodium Falciparum Malaria Prevention indication
Vasculitis of the skin off-label use 53312001
Porphyria cutanea tarda off-label use 61860000 DOID:3132
Q fever endocarditis off-label use 95890006
Coronavirus infection off-label use 186747009
Polymorphic light eruption off-label use 238525001
Juvenile rheumatoid arthritis off-label use 410795001
Hypercalcemia associated with Sarcoidosis off-label use
Alcoholism contraindication 7200002
Psoriasis contraindication 9014002 DOID:8893
Visual field defect contraindication 12184005
Retinal disorder contraindication 29555009 DOID:5679
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Neutropenic disorder contraindication 303011007 DOID:1227
Disorder of macula of retina contraindication 312999006
Disorder of eye contraindication 371405004 DOID:5614
Visual impairment contraindication 397540003
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.51 Basic
pKa2 7.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Toll-like receptor 7 Membrane receptor ANTAGONIST IC50 5.56 IUPHAR CHEMBL
Toll-like receptor 9 Membrane receptor ANTAGONIST IC50 7.10 IUPHAR CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 5.63 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel WOMBAT-PK
Hemoglobin subunit alpha Secreted WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 5.98 DRUG MATRIX
SARS-CoV-2 Virus INHIBITOR EC50 5.35 SCIENTIFIC LITERATURE

External reference:

IDSource
D006886 MESH_DESCRIPTOR_UI
4019780 VUID
N0000147871 NUI
C0020336 UMLSCUI
D02114 KEGG_DRUG
4QWG6N8QKH UNII
796 INN_ID
83490000 SNOMEDCT_US
5521 RXNORM
373540008 SNOMEDCT_US
4852 MMSL
d00817 MMSL
4019780 VANDF
004906 NDDF
747-36-4 SECONDARY_CAS_RN
CHEMBL1535 ChEMBL_ID
CHEMBL1690 ChEMBL_ID
DB01611 DRUGBANK_ID
CHEBI:5801 CHEBI
3652 PUBCHEM_CID
7198 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0373 TABLET, FILM COATED 200 mg ENTERAL ANDA 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3041 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8325 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1407 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6884 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16571-687 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-110 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-753 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 42292-011 TABLET, FILM COATED 200 mg ENTERAL ANDA 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 42385-927 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 43353-051 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 12 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 43598-721 TABLET 200 mg ORAL ANDA 10 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-2508 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3432 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-4659 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 53002-4850 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 53808-1112 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 55154-2074 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 57664-761 TABLET 200 mg ORAL ANDA 9 sections
Plaquenil HUMAN PRESCRIPTION DRUG LABEL 1 59212-562 TABLET 200 mg ORAL NDA 12 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 60219-1544 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 63304-296 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 63629-3343 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 11 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 63739-777 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 65841-633 TABLET, FILM COATED 200 mg ORAL ANDA 1 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 66993-057 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 11 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 67296-1780 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections
Plaquenil HUMAN PRESCRIPTION DRUG LABEL 1 67296-1781 TABLET 200 mg ORAL NDA 12 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 68071-4648 TABLET, FILM COATED 200 mg ORAL ANDA 12 sections