hydroxychloroquine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 1395 118-42-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydroxychloroquine
  • hydroxychloroquine sulfate
  • oxichloroquine
  • oxychlorochin
  • oxychloroquine
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970). In March 2020, FDA issued an emergency use authorization (EUA) for hydroxychloroquine and chloroquine in the treatment of COVID-10. EUA was revoked in June 2020. Data from various published randomized, controlled clinical trials and retrospective, cohort studies have not substantiated initial reports of efficacy of 4-aminoquinoline antimalarials for treatment of COVID-19.
  • Molecular weight: 335.88
  • Formula: C18H26ClN3O
  • CLOGP: 4.12
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 48.39
  • ALOGS: -4.11
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.52 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 200 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 27 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 29.77 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 700 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.57 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 850 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
April 18, 1955 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 7644.91 11.28 12060 437482 370544 55471981
Drug ineffective 6627.47 11.28 19061 430481 899928 54942597
Drug intolerance 4812.30 11.28 8011 441531 256807 55585718
Contraindicated product administered 3427.66 11.28 5673 443869 180613 55661912
Joint swelling 3150.46 11.28 7057 442485 282743 55559782
Synovitis 2985.61 11.28 4927 444615 156378 55686147
Treatment failure 2768.17 11.28 4912 444630 165480 55677045
Systemic lupus erythematosus 2195.56 11.28 4598 444944 175480 55667045
Therapeutic product effect decreased 2090.35 11.28 4348 445194 165104 55677421
Arthropathy 2008.05 11.28 4729 444813 195546 55646979
Pemphigus 1751.99 11.28 3872 445670 153340 55689185
Abdominal discomfort 1586.91 11.28 5341 444201 271933 55570592
Glossodynia 1427.67 11.28 3508 446034 148950 55693575
Hand deformity 1426.71 11.28 3249 446293 131243 55711282
Death 1404.59 11.28 488 449054 340938 55501587
Alopecia 1366.07 11.28 5285 444257 288173 55554352
Swelling 1305.46 11.28 4544 444998 235227 55607298
Pain 1221.46 11.28 9249 440293 653935 55188590
Arthralgia 1193.13 11.28 7453 442089 494216 55348309
C-reactive protein abnormal 987.96 11.28 1340 448202 35469 55807056
Hepatic enzyme increased 944.62 11.28 3263 446279 168121 55674404
Anti-cyclic citrullinated peptide antibody positive 942.50 11.28 2288 447254 96312 55746213
Rheumatoid factor positive 923.08 11.28 1834 447708 67226 55775299
Musculoskeletal stiffness 897.17 11.28 3013 446529 152994 55689531
Acute kidney injury 892.57 11.28 403 449139 240360 55602165
Wound 845.63 11.28 2734 446808 136070 55706455
Red blood cell sedimentation rate abnormal 779.08 11.28 850 448692 17823 55824702
Therapeutic product effect incomplete 770.55 11.28 2222 447320 103809 55738716
Pericarditis 759.35 11.28 2249 447293 106674 55735851
Completed suicide 757.14 11.28 90 449452 133743 55708782
Peripheral swelling 740.64 11.28 3767 445775 230959 55611566
Constipation 726.71 11.28 352 449190 201591 55640934
Anaemia 724.96 11.28 642 448900 266869 55575656
Off label use 707.82 11.28 7158 442384 549022 55293503
Discomfort 661.54 11.28 2558 446984 139203 55703322
Hypersensitivity 660.31 11.28 3894 445648 252514 55590011
Condition aggravated 636.96 11.28 4821 444721 340077 55502448
Hypotension 628.63 11.28 644 448898 249864 55592661
Dehydration 620.05 11.28 246 449296 158579 55683946
Rash 588.31 11.28 6265 443277 486782 55355743
Red blood cell sedimentation rate increased 581.37 11.28 1047 448495 35576 55806949
Product use issue 574.02 11.28 2968 446574 183073 55659452
Drug hypersensitivity 558.17 11.28 3935 445607 271270 55571255
Febrile neutropenia 543.30 11.28 94 449448 105451 55737074
C-reactive protein increased 538.97 11.28 1615 447927 77069 55765456
Loss of personal independence in daily activities 533.83 11.28 1645 447897 79724 55762801
Infusion related reaction 520.79 11.28 3147 446395 205784 55636741
Hyponatraemia 516.99 11.28 95 449447 102044 55740481
Gastrointestinal disorder 515.26 11.28 2021 447521 110681 55731844
Malignant neoplasm progression 497.05 11.28 21 449521 73566 55768959
Maternal exposure during pregnancy 493.44 11.28 2888 446654 186665 55655860
Seizure 487.93 11.28 194 449348 124925 55717600
Infection 476.47 11.28 2980 446562 197226 55645299
Tremor 475.07 11.28 186 449356 120903 55721622
Muscle injury 470.31 11.28 1189 448353 51311 55791214
Helicobacter infection 468.33 11.28 1468 448074 71800 55770725
Duodenal ulcer perforation 459.77 11.28 1394 448148 66948 55775577
Folliculitis 458.39 11.28 1212 448330 53767 55788758
Toxicity to various agents 458.22 11.28 677 448865 223887 55618638
Somnolence 421.19 11.28 410 449132 163003 55679522
Ill-defined disorder 420.39 11.28 1354 448188 67189 55775336
Irritable bowel syndrome 410.55 11.28 1342 448200 67116 55775409
Dyspnoea 406.11 11.28 2920 446622 589657 55252868
Drug interaction 404.33 11.28 657 448885 209098 55633427
Lower respiratory tract infection 399.60 11.28 1896 447646 112898 55729627
Drug abuse 396.10 11.28 40 449502 67570 55774955
Anxiety 386.59 11.28 590 448952 192582 55649943
Impaired healing 382.09 11.28 1539 448003 85302 55757223
Product dose omission issue 369.29 11.28 669 448873 204084 55638441
Atrial fibrillation 363.15 11.28 209 449333 108688 55733837
Fall 357.70 11.28 1554 447988 355956 55486569
Retinal toxicity 349.33 11.28 177 449365 1019 55841506
Neutropenia 346.31 11.28 453 449089 157714 55684811
Sleep disorder due to general medical condition, insomnia type 341.72 11.28 936 448606 42402 55800123
Dizziness 341.43 11.28 1694 447848 374446 55468079
Renal failure 340.97 11.28 232 449310 110268 55732257
Psoriatic arthropathy 339.56 11.28 1329 448213 72679 55769846
Thrombocytopenia 337.04 11.28 354 449188 135870 55706655
Bradycardia 332.62 11.28 67 449475 67437 55775088
Inflammation 328.03 11.28 1254 448288 67817 55774708
Pulmonary embolism 327.76 11.28 227 449315 106897 55735628
Overdose 318.85 11.28 228 449314 105602 55736923
Depressed level of consciousness 316.42 11.28 39 449503 56394 55786131
Knee arthroplasty 311.04 11.28 917 448625 43342 55799183
Blister 303.31 11.28 1690 447852 107197 55735328
Tachycardia 301.18 11.28 242 449300 105634 55736891
Disease progression 294.68 11.28 244 449298 104929 55737596
Rheumatoid nodule 294.40 11.28 469 449073 14388 55828137
Balance disorder 292.78 11.28 122 449420 76398 55766127
Urinary tract infection 292.50 11.28 965 448577 239548 55602977
Gastrointestinal haemorrhage 287.54 11.28 123 449419 75828 55766697
Multiple sclerosis relapse 283.90 11.28 19 449523 44884 55797641
Coma 282.12 11.28 65 449477 59590 55782935
Platelet count decreased 282.10 11.28 260 449282 106123 55736402
Mobility decreased 277.41 11.28 1539 448003 97452 55745073
Blood iron abnormal 270.88 11.28 221 449321 3156 55839369
Cerebrovascular accident 268.73 11.28 238 449304 99032 55743493
Cardio-respiratory arrest 268.23 11.28 57 449485 55264 55787261
Hyperkalaemia 266.79 11.28 43 449499 50822 55791703
Plasma cell myeloma 264.57 11.28 31 449511 46615 55795910
Musculoskeletal disorder 258.59 11.28 511 449031 18636 55823889
Agitation 257.26 11.28 65 449477 55971 55786554
Neutrophil count decreased 257.13 11.28 44 449498 49778 55792747
White blood cell count decreased 256.57 11.28 380 449162 125610 55716915
Sepsis 253.70 11.28 455 449087 139385 55703140
Abdominal pain 251.88 11.28 1136 448406 257669 55584856
Hip arthroplasty 251.42 11.28 779 448763 37844 55804681
Cognitive disorder 247.90 11.28 46 449496 49087 55793438
Arthritis 243.21 11.28 1496 448046 98356 55744169
Cardiac arrest 242.09 11.28 200 449342 86114 55756411
Intentional overdose 236.82 11.28 124 449418 67993 55774532
Diarrhoea 234.84 11.28 3639 445903 634868 55207657
Suicide attempt 233.16 11.28 85 449457 57751 55784774
Impaired work ability 232.97 11.28 418 449124 14154 55828371
Retinopathy 230.07 11.28 186 449356 2620 55839905
Oedema peripheral 228.04 11.28 659 448883 170595 55671930
Muscle spasms 226.54 11.28 473 449069 136898 55705627
Pulmonary fibrosis 223.99 11.28 632 448910 29126 55813399
Decreased appetite 221.93 11.28 948 448594 218283 55624242
Sinusitis 221.11 11.28 2482 447060 195099 55647426
Asthenia 220.81 11.28 1718 447824 341255 55501270
Syncope 218.67 11.28 328 449214 107871 55734654
Haemoglobin decreased 218.57 11.28 465 449077 133672 55708853
Hallucination 218.06 11.28 61 449481 49088 55793437
Osteoarthritis 218.06 11.28 1238 448304 79058 55763467
Hyperhidrosis 217.86 11.28 258 449284 93830 55748695
Respiratory failure 216.58 11.28 264 449278 94798 55747727
Cardiac failure 216.01 11.28 202 449340 81891 55760634
Blood glucose increased 212.16 11.28 173 449369 74978 55767547
Epistaxis 211.72 11.28 137 449405 66886 55775639
Neoplasm progression 210.14 11.28 11 449531 32005 55810520
Lactic acidosis 209.40 11.28 20 449522 35326 55807199
Sedation 208.41 11.28 19 449523 34835 55807690
Rhabdomyolysis 205.26 11.28 38 449504 40620 55801905
Joint range of motion decreased 205.08 11.28 553 448989 24812 55817713
Grip strength decreased 203.04 11.28 420 449122 15836 55826689
Fibromyalgia 201.11 11.28 976 448566 58627 55783898
Cardiac failure congestive 200.48 11.28 243 449299 87477 55755048
Bone erosion 199.05 11.28 397 449145 14577 55827948
Dysphagia 195.90 11.28 219 449323 81728 55760797
Metabolic acidosis 195.46 11.28 42 449500 40412 55802113
Device expulsion 192.15 11.28 13 449529 30436 55812089
Musculoskeletal pain 191.42 11.28 1206 448336 79946 55762579
Rheumatic fever 190.93 11.28 585 448957 28242 55814283
Chest pain 189.43 11.28 825 448717 188972 55653553
International normalised ratio increased 185.69 11.28 60 449482 43981 55798544
Deformity 183.27 11.28 309 449233 9946 55832579
Deep vein thrombosis 181.52 11.28 208 449334 76769 55765756
Wrong technique in product usage process 180.88 11.28 121 449421 58047 55784478
Disability 177.82 11.28 391 449151 15389 55827136
Neuropathy peripheral 176.68 11.28 346 449196 102547 55739978
Disturbance in attention 176.39 11.28 25 449517 32515 55810010
Tenosynovitis 176.10 11.28 339 449203 12122 55830403
Chest discomfort 175.37 11.28 326 449216 98531 55743994
Swollen joint count increased 173.64 11.28 505 449037 23679 55818846
Asthma 172.19 11.28 405 449137 112365 55730160
Intentional product use issue 172.08 11.28 1374 448168 98359 55744166
Serotonin syndrome 171.07 11.28 10 449532 26480 55816045
Depression 170.69 11.28 798 448744 179319 55663206
Hypoxia 167.75 11.28 112 449430 53785 55788740
Bone pain 167.69 11.28 96 449446 50089 55792436
Hypoglycaemia 167.07 11.28 121 449421 55694 55786831
Drug tolerance decreased 164.57 11.28 344 449198 13067 55829458
Pneumonia 162.80 11.28 2281 447261 404817 55437708
Feeling abnormal 162.26 11.28 536 449006 133066 55709459
Blood parathyroid hormone decreased 161.56 11.28 261 449281 8103 55834422
Blood pressure decreased 160.46 11.28 141 449401 58909 55783616
Respiratory arrest 160.35 11.28 26 449516 30599 55811926
Paraesthesia 160.31 11.28 521 449021 129993 55712532
Stomatitis 160.16 11.28 1571 447971 119239 55723286
Granuloma skin 159.97 11.28 237 449305 6814 55835711
Deafness transitory 159.80 11.28 129 449413 1813 55840712
Cough 158.93 11.28 1320 448222 258641 55583884
Panniculitis 156.92 11.28 282 449260 9560 55832965
Vomiting 156.31 11.28 2921 446621 495307 55347218
Myalgia 156.01 11.28 536 449006 131489 55711036
Pleural effusion 155.98 11.28 277 449265 85203 55757322
Blood cholesterol increased 154.95 11.28 1052 448490 71527 55770998
Pancytopenia 152.58 11.28 298 449244 88417 55754108
Maculopathy 149.89 11.28 127 449415 1917 55840608
Vision blurred 149.35 11.28 271 449271 82672 55759853
Encephalopathy 149.15 11.28 48 449494 35277 55807248
Pneumonia aspiration 147.98 11.28 38 449504 32373 55810152
Therapeutic response decreased 146.21 11.28 818 448724 51940 55790585
Fluid retention 145.89 11.28 130 449412 53948 55788577
Dyskinesia 145.24 11.28 28 449514 29080 55813445
Blood calcium decreased 144.72 11.28 12 449530 23757 55818768
Sopor 144.57 11.28 5 449537 20917 55821608
Joint stiffness 144.04 11.28 613 448929 34812 55807713
Nasopharyngitis 143.94 11.28 2522 447020 218437 55624088
Melaena 143.75 11.28 26 449516 28264 55814261
Gastrooesophageal reflux disease 142.90 11.28 280 449262 82977 55759548
Pulmonary oedema 142.77 11.28 119 449423 51024 55791501
Drug withdrawal syndrome 142.20 11.28 19 449523 25838 55816687
Unresponsive to stimuli 141.43 11.28 39 449503 31686 55810839
Hypokalaemia 140.32 11.28 344 449198 94093 55748432
Hyperglycaemia 140.14 11.28 65 449477 38216 55804309
Blood bilirubin increased 139.63 11.28 46 449496 33308 55809217
Palmar-plantar erythrodysaesthesia syndrome 139.00 11.28 7 449535 21058 55821467
Pulmonary toxicity 138.85 11.28 236 449306 7647 55834878
Disorientation 137.42 11.28 60 449482 36553 55805972
Haemorrhage 136.67 11.28 149 449393 56248 55786277
Suicidal ideation 136.15 11.28 156 449386 57586 55784939
Shoulder arthroplasty 136.02 11.28 158 449384 3555 55838970
Lupus nephritis 135.91 11.28 137 449405 2610 55839915
Hepatic failure 135.32 11.28 49 449493 33437 55809088
Dysarthria 134.52 11.28 74 449468 39476 55803049
Palpitations 134.46 11.28 381 449161 99291 55743234
Product quality issue 134.21 11.28 43 449499 31693 55810832
Cerebral haemorrhage 133.59 11.28 32 449510 28574 55813951
Irritability 132.60 11.28 36 449506 29552 55812973
Multiple organ dysfunction syndrome 131.70 11.28 136 449406 52634 55789891
Mental status changes 130.73 11.28 68 449474 37433 55805092
Rectal haemorrhage 130.63 11.28 85 449457 41382 55801143
Nausea 129.90 11.28 4895 444647 759283 55083242
Restlessness 129.67 11.28 27 449515 26559 55815966
Colitis 127.29 11.28 89 449453 41722 55800803
Vertigo 125.91 11.28 150 449392 54422 55788103
Chills 125.00 11.28 411 449131 102193 55740332
Myocardial infarction 124.53 11.28 356 449186 92514 55750011
Lethargy 123.44 11.28 137 449405 51304 55791221
Hepatic function abnormal 122.95 11.28 61 449481 34497 55808028
Finger deformity 122.65 11.28 202 449340 6375 55836150
Flushing 121.82 11.28 234 449308 69866 55772659
Fatigue 121.81 11.28 7566 441976 780986 55061539
Cholelithiasis 121.47 11.28 83 449459 39381 55803144
Metastases to bone 121.15 11.28 9 449533 19499 55823026
Pyrexia 120.33 11.28 2491 447051 416282 55426243
Polyarthritis 119.13 11.28 234 449308 8494 55834031
Hypomagnesaemia 118.77 11.28 27 449515 24988 55817537
Abnormal behaviour 118.69 11.28 12 449530 20260 55822265
Joint effusion 118.62 11.28 323 449219 14575 55827950
Blood alkaline phosphatase increased 118.43 11.28 83 449459 38862 55803663
Adverse event 118.39 11.28 803 448739 54573 55787952
Dysgeusia 118.21 11.28 92 449450 40823 55801702
Generalised tonic-clonic seizure 117.19 11.28 37 449505 27529 55814996
Osteonecrosis of jaw 117.00 11.28 60 449482 33298 55809227
Hospitalisation 116.35 11.28 267 449275 74733 55767792
Joint destruction 116.25 11.28 171 449371 4884 55837641
Accidental overdose 115.02 11.28 14 449528 20447 55822078
Intentional self-injury 114.68 11.28 29 449513 24963 55817562
Urinary retention 113.58 11.28 41 449501 28033 55814492
X-ray abnormal 113.32 11.28 156 449386 4185 55838340
Emotional distress 111.35 11.28 49 449493 29714 55812811
Mucosal inflammation 110.64 11.28 107 449435 42703 55799822
Renal impairment 109.98 11.28 307 449235 80406 55762119
Aphasia 109.25 11.28 53 449489 30362 55812163
Epilepsy 108.82 11.28 33 449509 25198 55817327
Device dislocation 108.13 11.28 24 449518 22582 55819943
Ascites 107.73 11.28 85 449457 37459 55805066
Liver function test increased 107.62 11.28 478 449064 27655 55814870
Abdominal distension 107.46 11.28 293 449249 77333 55765192
Full blood count decreased 107.32 11.28 27 449515 23322 55819203
Adverse drug reaction 107.26 11.28 888 448654 64244 55778281
Jaundice 106.84 11.28 42 449500 27252 55815273
Musculoskeletal deformity 106.17 11.28 92 449450 1434 55841091
Fine motor skill dysfunction 105.52 11.28 153 449389 4312 55838213
Haematoma 104.49 11.28 63 449479 31956 55810569
Chronic kidney disease 103.13 11.28 110 449432 41946 55800579
Metastases to liver 103.08 11.28 23 449519 21563 55820962
Gamma-glutamyltransferase increased 102.59 11.28 60 449482 30945 55811580
Respiratory distress 102.37 11.28 63 449479 31604 55810921
Elbow deformity 101.59 11.28 88 449454 1371 55841154
Haematochezia 101.03 11.28 120 449422 43598 55798927
Erythema 100.63 11.28 780 448762 155159 55687366
Neutropenic sepsis 100.34 11.28 5 449537 15180 55827345
Transient ischaemic attack 98.91 11.28 74 449468 33503 55809022
Lymphocyte count decreased 98.37 11.28 50 449492 27889 55814636
Altered state of consciousness 97.69 11.28 31 449511 22990 55819535
Joint injury 96.72 11.28 434 449108 25220 55817305
Incorrect dose administered 96.09 11.28 170 449372 52377 55790148
Orthostatic hypotension 95.46 11.28 75 449467 33124 55809401
Blood potassium decreased 94.99 11.28 101 449441 38571 55803954
Acute myocardial infarction 94.78 11.28 63 449479 30330 55812195
Swollen tongue 94.37 11.28 63 449479 30261 55812264
Bone density decreased 94.06 11.28 269 449273 12491 55830034
Status epilepticus 93.99 11.28 7 449535 15134 55827391
Liver injury 93.76 11.28 614 448928 41234 55801291
Multiple sclerosis 93.13 11.28 53 449489 27749 55814776
Dry skin 93.02 11.28 145 449397 46964 55795561
Tuberculin test positive 93.02 11.28 124 449418 3223 55839302
Acute respiratory failure 93.00 11.28 67 449475 30927 55811598
Aggression 92.73 11.28 30 449512 21976 55820549
Weight decreased 90.66 11.28 1364 448178 239350 55603175
Blood urea increased 90.44 11.28 41 449501 24432 55818093
Bone marrow failure 90.43 11.28 57 449485 28229 55814296
Diabetic ketoacidosis 90.33 11.28 20 449522 18851 55823674
Nodule 89.94 11.28 340 449202 18279 55824246
Foot deformity 89.78 11.28 403 449139 23422 55819103
Creatinine renal clearance decreased 89.61 11.28 7 449535 14552 55827973
Coronary artery disease 89.27 11.28 69 449473 30727 55811798
Injection site pain 89.24 11.28 558 448984 116560 55725965
Dysuria 88.89 11.28 69 449473 30660 55811865
Memory impairment 88.86 11.28 372 449170 86185 55756340
SLE arthritis 88.83 11.28 58 449484 572 55841953
Small intestinal obstruction 88.72 11.28 14 449528 16811 55825714
Intentional product misuse 88.54 11.28 173 449369 51331 55791194
Accidental exposure to product 88.45 11.28 43 449499 24604 55817921
Upper gastrointestinal haemorrhage 88.12 11.28 15 449527 17039 55825486
Speech disorder 87.62 11.28 102 449440 37391 55805134
Flatulence 87.07 11.28 73 449469 31215 55811310
Chronic obstructive pulmonary disease 86.96 11.28 207 449335 57208 55785317
Circulatory collapse 86.53 11.28 29 449513 20774 55821751
Osteoporosis 86.41 11.28 711 448831 51341 55791184
Drug level increased 86.02 11.28 29 449513 20696 55821829
Renal phospholipidosis 85.68 11.28 32 449510 72 55842453
Tubulointerstitial nephritis 85.36 11.28 15 449527 16650 55825875
Cardiac disorder 85.23 11.28 147 449395 45740 55796785
Spinal stenosis 85.08 11.28 276 449266 13738 55828787
Gastritis 84.83 11.28 91 449451 34611 55807914
Skin necrosis 84.80 11.28 254 449288 12107 55830418
Arrhythmia 84.65 11.28 93 449449 34990 55807535
Product prescribing error 83.89 11.28 40 449502 23146 55819379
Arthrodesis 83.85 11.28 105 449437 2561 55839964
Hypervolaemia 83.65 11.28 54 449488 26404 55816121
Oxygen saturation decreased 83.55 11.28 336 449206 78731 55763794
Swelling face 83.45 11.28 204 449338 55865 55786660
Acute myeloid leukaemia 83.26 11.28 17 449525 16955 55825570
Adverse reaction 82.79 11.28 212 449330 9215 55833310
Type 2 diabetes mellitus 82.63 11.28 649 448893 46213 55796312
Respiratory depression 82.47 11.28 4 449538 12431 55830094
Body height below normal 82.46 11.28 91 449451 1932 55840593
Product administration error 82.26 11.28 32 449510 20897 55821628
Withdrawal syndrome 81.72 11.28 23 449519 18439 55824086
Acute hepatic failure 80.51 11.28 17 449525 16561 55825964
Dementia 80.50 11.28 19 449523 17139 55825386
Ischaemic stroke 80.31 11.28 18 449524 16824 55825701
Urinary incontinence 79.93 11.28 71 449471 29514 55813011
Human antichimeric antibody positive 79.26 11.28 79 449463 1484 55841041
Pancreatitis 78.73 11.28 150 449392 44930 55797595
Eye disorder 78.61 11.28 348 449194 20104 55822421
Joint laxity 78.21 11.28 97 449445 2342 55840183
Cerebral infarction 78.15 11.28 41 449501 22464 55820061
Pallor 78.12 11.28 48 449494 24101 55818424
Inappropriate schedule of product administration 77.99 11.28 371 449171 83016 55759509
Pulmonary arterial hypertension 77.31 11.28 59 449483 26444 55816081
Myoclonus 77.18 11.28 14 449528 15189 55827336
Full blood count abnormal 77.07 11.28 59 449483 26403 55816122
Gastrointestinal pain 76.69 11.28 197 449345 8580 55833945
Haematemesis 76.52 11.28 70 449472 28688 55813837
Drug eruption 76.44 11.28 407 449135 25356 55817169
Oral mucosal exfoliation 76.34 11.28 78 449464 1511 55841014
Feeling hot 75.68 11.28 136 449406 41651 55800874
Hallucination, visual 75.05 11.28 23 449519 17445 55825080
Hemiparesis 74.85 11.28 39 449503 21451 55821074
Ear pain 74.62 11.28 462 449080 30428 55812097
Rheumatoid factor negative 74.41 11.28 51 449491 549 55841976
Device related infection 74.31 11.28 41 449501 21839 55820686
Physical disability 74.09 11.28 93 449449 2274 55840251
Cytokine release syndrome 73.76 11.28 3 449539 10872 55831653
Hypoaesthesia 73.54 11.28 748 448794 140743 55701782
Blood creatinine increased 73.13 11.28 360 449182 79831 55762694
Neurotoxicity 73.10 11.28 18 449524 15777 55826748
Back pain 73.00 11.28 1394 448148 235776 55606749
Night sweats 72.79 11.28 571 448971 40642 55801883
Therapy non-responder 72.72 11.28 780 448762 60575 55781950
Surgical failure 72.56 11.28 60 449482 874 55841651
Muscle spasticity 72.50 11.28 334 449208 19626 55822899
Hepatocellular injury 72.39 11.28 63 449479 26451 55816074
Mental disorder 72.17 11.28 50 449492 23554 55818971
Obstructive airways disorder 72.04 11.28 24 449518 17258 55825267
Complication associated with device 72.01 11.28 17 449525 15333 55827192
Red blood cell sedimentation rate 71.98 11.28 126 449416 4182 55838343
Electrolyte imbalance 71.83 11.28 27 449515 18006 55824519
Subacute cutaneous lupus erythematosus 71.47 11.28 91 449451 2258 55840267
Clostridium difficile colitis 71.44 11.28 30 449512 18708 55823817
Inappropriate antidiuretic hormone secretion 71.29 11.28 12 449530 13744 55828781
Colitis microscopic 71.14 11.28 179 449363 7696 55834829
Disseminated intravascular coagulation 70.87 11.28 27 449515 17858 55824667
Cellulitis 70.36 11.28 333 449209 74616 55767909
Ulcer 69.31 11.28 359 449183 22126 55820399
Neuroleptic malignant syndrome 69.31 11.28 6 449536 11472 55831053
Rheumatoid lung 69.02 11.28 104 449438 3036 55839489
Juvenile idiopathic arthritis 68.85 11.28 131 449411 4642 55837883
Muscle twitching 68.69 11.28 22 449520 16220 55826305
Diabetes mellitus inadequate control 68.59 11.28 14 449528 13966 55828559
Heart rate increased 68.04 11.28 388 449154 82885 55759640
Sciatica 67.92 11.28 397 449145 25613 55816912
Blood lactate dehydrogenase increased 67.01 11.28 41 449501 20634 55821891
Mania 66.97 11.28 7 449535 11513 55831012
Pulmonary hypertension 66.89 11.28 115 449427 35829 55806696
Wheelchair user 66.82 11.28 140 449402 5326 55837199
Head injury 66.71 11.28 61 449481 25005 55817520
Poisoning deliberate 66.66 11.28 3 449539 9950 55832575
Interstitial lung disease 66.50 11.28 723 448819 56340 55786185
Sleep apnoea syndrome 66.34 11.28 66 449476 25995 55816530
Depressed mood 66.14 11.28 118 449424 36241 55806284
Epicondylitis 66.07 11.28 81 449461 1932 55840593
Abortion spontaneous 66.05 11.28 158 449384 43595 55798930
Coordination abnormal 65.43 11.28 11 449531 12610 55829915
Breast cancer metastatic 65.33 11.28 21 449521 15448 55827077
Thrombosis 65.04 11.28 249 449293 59178 55783347
Seronegative arthritis 65.01 11.28 94 449448 2642 55839883
Spinal column injury 64.55 11.28 78 449464 1832 55840693
Abdominal pain lower 64.11 11.28 54 449488 23038 55819487
Paranoia 63.85 11.28 6 449536 10738 55831787
Parkinsonism 63.53 11.28 3 449539 9543 55832982
Blood sodium decreased 63.53 11.28 51 449491 22283 55820242
Mouth ulceration 63.45 11.28 430 449112 29210 55813315
Enthesopathy 63.38 11.28 174 449368 7889 55834636
Onychomycosis 63.20 11.28 153 449389 6419 55836106
Pneumonia viral 62.89 11.28 161 449381 6997 55835528
Device issue 62.83 11.28 46 449496 21060 55821465
Cyanosis 62.42 11.28 24 449518 15786 55826739
Investigation abnormal 62.41 11.28 73 449469 1655 55840870
Herpes zoster 62.04 11.28 900 448642 74989 55767536
Metastases to central nervous system 61.99 11.28 11 449531 12125 55830400
Vaginal haemorrhage 60.90 11.28 69 449473 25604 55816921
Coagulopathy 60.82 11.28 37 449505 18679 55823846
Glaucoma 60.76 11.28 287 449255 17042 55825483
Loose body in joint 60.60 11.28 62 449480 1203 55841322
Muscular weakness 60.30 11.28 538 449004 103914 55738611
Cytomegalovirus infection 60.16 11.28 40 449502 19256 55823269
Sleep disorder 59.97 11.28 814 448728 66849 55775676
Extrapyramidal disorder 59.33 11.28 13 449529 12343 55830182
Anuria 59.33 11.28 11 449531 11749 55830776
Haematuria 59.29 11.28 77 449465 26910 55815615
Cholestasis 58.91 11.28 77 449465 26836 55815689
Blood triglycerides increased 58.75 11.28 11 449531 11666 55830859
Dislocation of vertebra 58.56 11.28 132 449410 5283 55837242
Psychotic disorder 58.45 11.28 61 449481 23497 55819028
Tachypnoea 58.36 11.28 25 449517 15405 55827120
Blood pressure increased 58.32 11.28 812 448730 144364 55698161
Hypothermia 58.13 11.28 14 449528 12456 55830069
Respiratory disorder 58.06 11.28 467 449075 33490 55809035
Pulmonary congestion 58.00 11.28 28 449514 16087 55826438
Mental impairment 57.91 11.28 15 449527 12707 55829818
Wrist deformity 57.78 11.28 73 449469 1797 55840728
Hot flush 57.69 11.28 186 449356 46540 55795985
Skin exfoliation 57.51 11.28 131 449411 36769 55805756
Body temperature increased 56.97 11.28 468 449074 33774 55808751
Dyspnoea exertional 56.77 11.28 234 449308 54455 55788070
Akathisia 56.69 11.28 3 449539 8649 55833876
Anger 56.62 11.28 12 449530 11660 55830865
Hyperthyroidism 56.62 11.28 18 449524 13334 55829191
Intestinal obstruction 56.27 11.28 85 449457 27886 55814639
Hypophosphataemia 56.14 11.28 6 449536 9696 55832829
Feeling cold 55.86 11.28 52 449490 21135 55821390
Hepatotoxicity 55.77 11.28 433 449109 30720 55811805
Multiple fractures 55.31 11.28 156 449386 7185 55835340
Paraesthesia oral 55.30 11.28 23 449519 14426 55828099
Viral upper respiratory tract infection 54.67 11.28 154 449388 7088 55835437
Incontinence 54.25 11.28 10 449532 10725 55831800
Heart rate irregular 54.23 11.28 51 449491 20628 55821897
Leukocytosis 54.23 11.28 66 449476 23725 55818800
Blood magnesium decreased 54.05 11.28 14 449528 11860 55830665
Muscle rigidity 53.80 11.28 10 449532 10661 55831864
Renal disorder 53.03 11.28 97 449445 29508 55813017
Fear of injection 52.61 11.28 142 449400 6373 55836152
Blood glucose decreased 52.54 11.28 45 449497 19042 55823483
Mydriasis 52.45 11.28 12 449530 11059 55831466
Device difficult to use 52.33 11.28 11 449531 10750 55831775
Pollakiuria 52.25 11.28 75 449467 25127 55817398
Hypersomnia 52.14 11.28 33 449509 16308 55826217
Wheezing 51.35 11.28 369 449173 74657 55767868
Poisoning 51.34 11.28 19 449523 12794 55829731
Metastases to lung 51.12 11.28 15 449527 11703 55830822
Transfusion 50.98 11.28 22 449520 13498 55829027
Lip swelling 50.79 11.28 82 449460 26190 55816335
Delirium 50.59 11.28 172 449370 42345 55800180
Blood creatine phosphokinase increased 50.59 11.28 91 449451 27861 55814664
Angioedema 50.49 11.28 166 449376 41287 55801238
Vascular access complication 50.16 11.28 65 449477 1642 55840883
Ileus 50.14 11.28 24 449518 13858 55828667
Infective pulmonary exacerbation of cystic fibrosis 49.98 11.28 4 449538 8153 55834372
Dermatomyositis 49.95 11.28 83 449459 2639 55839886
Injection site erythema 49.64 11.28 388 449154 77060 55765465
Skin discolouration 49.56 11.28 127 449415 34229 55808296
Back injury 49.56 11.28 159 449383 7867 55834658
Myelosuppression 49.47 11.28 40 449502 17415 55825110
Malnutrition 49.41 11.28 25 449517 13983 55828542
Basal cell carcinoma 49.35 11.28 358 449184 24863 55817662
Red cell distribution width decreased 49.09 11.28 63 449479 1576 55840949
Eye swelling 49.04 11.28 59 449483 21317 55821208
Loss of consciousness 48.91 11.28 598 448944 108751 55733774
Shock haemorrhagic 48.81 11.28 7 449535 9026 55833499
Nervous system disorder 48.75 11.28 38 449504 16851 55825674
Product label confusion 48.67 11.28 50 449492 975 55841550
Blood albumin decreased 48.56 11.28 24 449518 13604 55828921
Aplastic anaemia 48.06 11.28 7 449535 8921 55833604
Angina pectoris 48.05 11.28 94 449448 27882 55814643
Alanine aminotransferase increased 47.88 11.28 497 449045 93165 55749360
Psoriasis 47.74 11.28 491 449051 92201 55750324
Therapy cessation 47.36 11.28 91 449451 27173 55815352
Nightmare 47.14 11.28 39 449503 16787 55825738
Nervousness 46.86 11.28 101 449441 28914 55813611
Synovial cyst 46.79 11.28 171 449371 9043 55833482
Haemoptysis 46.71 11.28 88 449454 26472 55816053
Anal incontinence 46.39 11.28 20 449522 12278 55830247
Sinus tachycardia 46.32 11.28 67 449475 22377 55820148
Subdural haematoma 46.27 11.28 25 449517 13474 55829051
Amenorrhoea 46.21 11.28 8 449534 8978 55833547
Clostridium difficile infection 46.19 11.28 92 449450 27106 55815419
Pancreatitis acute 46.18 11.28 81 449461 25043 55817482
Haemorrhage intracranial 46.15 11.28 22 449520 12733 55829792
Foot operation 46.07 11.28 132 449410 6135 55836390
Ataxia 46.07 11.28 29 449513 14374 55828151
Drug resistance 45.76 11.28 58 449484 20484 55822041
Sinus bradycardia 45.36 11.28 26 449516 13560 55828965
Pericardial effusion 45.23 11.28 93 449449 27082 55815443
Hip fracture 45.15 11.28 92 449450 26881 55815644
Hypothyroidism 45.12 11.28 155 449387 38041 55804484
Ankle arthroplasty 45.12 11.28 57 449485 1403 55841122
Dialysis 45.01 11.28 11 449531 9691 55832834
Bone swelling 45.01 11.28 58 449484 1457 55841068
Cholecystitis 44.90 11.28 30 449512 14405 55828120
Brain oedema 44.88 11.28 25 449517 13246 55829279
Mean platelet volume decreased 44.48 11.28 70 449472 2124 55840401
Aspiration 44.46 11.28 11 449531 9610 55832915
Delusion 44.32 11.28 17 449525 11198 55831327
Staphylococcal infection 44.21 11.28 153 449389 37465 55805060
Haematotoxicity 44.14 11.28 7 449535 8376 55834149
Ocular toxicity 43.87 11.28 39 449503 630 55841895
Contusion 43.74 11.28 1339 448203 127091 55715434
Hypoalbuminaemia 43.69 11.28 15 449527 10584 55831941
Retching 43.61 11.28 27 449515 13503 55829022
Subarachnoid haemorrhage 43.53 11.28 18 449524 11329 55831196
Retinitis 43.50 11.28 101 449441 4123 55838402
Glomerular filtration rate decreased 43.50 11.28 22 449520 12307 55830218
Onychomadesis 43.37 11.28 108 449434 4613 55837912
Presyncope 43.04 11.28 87 449455 25495 55817030
Mesenteritis 42.93 11.28 26 449516 222 55842303
Aspartate aminotransferase increased 42.76 11.28 437 449105 82165 55760360
Breast cancer stage III 42.52 11.28 140 449402 7023 55835502
Graft versus host disease 42.48 11.28 3 449539 6778 55835747
Infusion site reaction 42.37 11.28 80 449462 2818 55839707
Panic attack 42.24 11.28 61 449481 20386 55822139
Hepatitis 42.19 11.28 451 449091 34990 55807535
International normalised ratio fluctuation 42.16 11.28 72 449470 2342 55840183
Shock 41.83 11.28 68 449474 21660 55820865
Renal tubular necrosis 41.82 11.28 17 449525 10811 55831714
Antibody test positive 41.79 11.28 72 449470 2359 55840166
Acute coronary syndrome 41.72 11.28 13 449529 9755 55832770
Lymphoedema 41.55 11.28 16 449526 10514 55832011
Urine output decreased 41.50 11.28 17 449525 10760 55831765
Taste disorder 41.36 11.28 13 449529 9702 55832823
Acidosis 41.36 11.28 16 449526 10485 55832040
Mood altered 41.21 11.28 28 449514 13327 55829198
Thrombotic microangiopathy 41.14 11.28 12 449530 9399 55833126
Faeces discoloured 41.06 11.28 45 449497 16951 55825574
Neck pain 40.84 11.28 705 448837 60850 55781675
Glycosylated haemoglobin increased 40.79 11.28 19 449523 11146 55831379
Hepatic cytolysis 40.72 11.28 18 449524 10888 55831637
Hepatic encephalopathy 40.50 11.28 15 449527 10095 55832430
Bacteraemia 40.46 11.28 39 449503 15592 55826933
Labelled drug-drug interaction medication error 40.39 11.28 21 449521 11565 55830960
Lipase increased 40.09 11.28 11 449531 8968 55833557
Right ventricular failure 39.97 11.28 43 449499 16336 55826189
Cholecystitis chronic 39.83 11.28 14 449528 9734 55832791
Crohn's disease 39.81 11.28 3 449539 6424 55836101
Dystonia 39.74 11.28 25 449517 12396 55830129
Faecaloma 39.67 11.28 6 449536 7435 55835090
Influenza 39.61 11.28 529 449013 94732 55747793
Acquired pigmented retinopathy 39.59 11.28 11 449531 3 55842522
Caesarean section 39.54 11.28 42 449500 16049 55826476
Supraventricular tachycardia 39.52 11.28 29 449513 13262 55829263
Phospholipidosis 39.37 11.28 16 449526 49 55842476
Bone density abnormal 39.29 11.28 83 449459 3176 55839349
Hypoacusis 39.27 11.28 71 449471 21697 55820828
Ejection fraction decreased 39.23 11.28 61 449481 19780 55822745
Abnormal dreams 39.18 11.28 14 449528 9635 55832890
Face oedema 39.16 11.28 54 449488 18398 55824127
Joint arthroplasty 38.99 11.28 73 449469 2555 55839970
Underdose 38.95 11.28 82 449460 23675 55818850
Hypocalcaemia 38.71 11.28 110 449432 28650 55813875
Mycotic allergy 38.69 11.28 40 449502 786 55841739
Cardiogenic shock 38.59 11.28 44 449498 16281 55826244
Throat irritation 38.36 11.28 133 449409 32550 55809975
Ovarian neoplasm 38.34 11.28 41 449501 839 55841686
Breast cancer stage I 38.33 11.28 3 449539 6227 55836298
Polyuria 38.23 11.28 7 449535 7544 55834981
Influenza like illness 37.94 11.28 308 449234 60680 55781845
Myelodysplastic syndrome 37.94 11.28 45 449497 16361 55826164
Transaminases abnormal 37.76 11.28 34 449508 559 55841966
Anticipatory anxiety 37.60 11.28 44 449498 998 55841527
Haemodialysis 37.48 11.28 11 449531 8580 55833945
Presbyacusis 37.42 11.28 75 449467 2763 55839762
Metastases to lymph nodes 37.33 11.28 7 449535 7416 55835109
Lupus-like syndrome 37.33 11.28 197 449345 12230 55830295
Bloody discharge 37.27 11.28 52 449490 1413 55841112
Enterocolitis 37.26 11.28 6 449536 7098 55835427
Ageusia 37.24 11.28 27 449515 12424 55830101
Pleural thickening 37.16 11.28 73 449469 2650 55839875
Drug reaction with eosinophilia and systemic symptoms 37.15 11.28 121 449421 30183 55812342
Cystitis 37.14 11.28 234 449308 48804 55793721
Heavy menstrual bleeding 36.91 11.28 45 449497 16164 55826361
Injection site mass 36.80 11.28 48 449494 16745 55825780
Therapy interrupted 36.75 11.28 95 449447 25530 55816995
Myocardial ischaemia 36.60 11.28 26 449516 12090 55830435
Brain injury 36.59 11.28 4 449538 6351 55836174
Macular degeneration 36.56 11.28 59 449483 18849 55823676
Device malfunction 36.53 11.28 45 449497 16091 55826434
Agranulocytosis 36.49 11.28 79 449463 22580 55819945
White blood cell count increased 36.31 11.28 209 449333 44550 55797975
Amnesia 36.14 11.28 219 449323 46103 55796422
Lupus vasculitis 36.10 11.28 31 449511 477 55842048
Burning sensation 36.05 11.28 234 449308 48462 55794063
Osteoporotic fracture 35.96 11.28 81 449461 3240 55839285
Rash macular 35.59 11.28 69 449473 20535 55821990
Incorrect product administration duration 35.58 11.28 19 449523 10307 55832218
Petechiae 35.57 11.28 31 449511 13008 55829517
Personality change 35.24 11.28 3 449539 5814 55836711
Premature labour 35.23 11.28 26 449516 11856 55830669
Hypoaesthesia oral 35.23 11.28 24 449518 11407 55831118
Laryngeal disorder 35.17 11.28 41 449501 926 55841599
Anti-cyclic citrullinated peptide antibody 35.08 11.28 86 449456 3637 55838888
Eye pruritus 35.00 11.28 37 449505 14169 55828356
Cutaneous lupus erythematosus 34.93 11.28 69 449473 2515 55840010
Frequent bowel movements 34.92 11.28 48 449494 16376 55826149
Infusion site pain 34.86 11.28 35 449507 13727 55828798
Arteriosclerosis 34.67 11.28 16 449526 9437 55833088
Eye pain 34.56 11.28 128 449414 30719 55811806
Rash erythematous 34.56 11.28 166 449376 37055 55805470
Intermenstrual bleeding 34.55 11.28 7 449535 7020 55835505
Diplopia 34.50 11.28 69 449473 20300 55822225
Hemiplegia 34.46 11.28 12 449530 8392 55834133
Seasonal allergy 34.40 11.28 52 449490 17056 55825469
Neck mass 34.37 11.28 81 449461 3339 55839186
Live birth 34.26 11.28 271 449271 19334 55823191
Upper respiratory tract infection 34.13 11.28 384 449158 70904 55771621
Infusion site erythema 34.10 11.28 17 449525 9589 55832936
Psychomotor hyperactivity 33.93 11.28 18 449524 9802 55832723
Lacrimation increased 33.86 11.28 59 449483 18289 55824236
Pleural fibrosis 33.77 11.28 81 449461 3378 55839147
Overlap syndrome 33.76 11.28 34 449508 647 55841878
Prothrombin time prolonged 33.75 11.28 15 449527 9045 55833480
Colitis ischaemic 33.70 11.28 19 449523 10001 55832524
Visual acuity reduced 33.59 11.28 72 449470 20654 55821871
Ear infection 33.50 11.28 390 449152 30905 55811620
Cutaneous vasculitis 33.47 11.28 99 449443 4685 55837840
Sensitivity to weather change 33.43 11.28 123 449419 6526 55835999
Dysphonia 33.42 11.28 197 449345 41750 55800775
Hypovolaemia 33.41 11.28 18 449524 9717 55832808
Cholecystitis acute 33.27 11.28 9 449533 7407 55835118
Central nervous system lesion 33.21 11.28 19 449523 9919 55832606
Hallucination, auditory 33.17 11.28 26 449516 11498 55831027
Anhedonia 33.06 11.28 19 449523 9895 55832630
Throat tightness 32.96 11.28 82 449460 22325 55820200
Hospice care 32.91 11.28 5 449537 6175 55836350
Laboratory test abnormal 32.84 11.28 95 449447 24600 55817925
Anovulatory cycle 32.70 11.28 19 449523 149 55842376
Salivary hypersecretion 32.69 11.28 8 449534 7042 55835483
Nasal congestion 32.67 11.28 290 449252 56080 55786445
Suspected suicide 32.62 11.28 3 449539 5463 55837062
Mean cell volume decreased 32.56 11.28 80 449462 3388 55839137
Stevens-Johnson syndrome 32.52 11.28 84 449458 22579 55819946
Restrictive cardiomyopathy 32.51 11.28 24 449518 293 55842232
Asphyxia 32.44 11.28 4 449538 5785 55836740
Fracture 32.30 11.28 59 449483 17959 55824566
Pharyngitis 32.26 11.28 256 449286 18282 55824243
Hyperbilirubinaemia 32.20 11.28 21 449521 10214 55832311
Diarrhoea haemorrhagic 32.10 11.28 12 449530 8031 55834494
Extremity contracture 31.95 11.28 45 449497 1234 55841291
Gastrointestinal toxicity 31.90 11.28 115 449427 6041 55836484
Needle issue 31.72 11.28 15 449527 8723 55833802
Motor dysfunction 31.71 11.28 18 449524 9439 55833086
Device breakage 31.68 11.28 21 449521 10126 55832399
Activated partial thromboplastin time prolonged 31.66 11.28 7 449535 6605 55835920
Post procedural haemorrhage 31.66 11.28 10 449532 7439 55835086
Sensory disturbance 31.66 11.28 32 449510 12511 55830014
Pemphigoid 31.55 11.28 6 449536 6294 55836231
Hypotonia 31.34 11.28 15 449527 8662 55833863
Soft tissue disorder 31.29 11.28 90 449452 4192 55838333
Hiatus hernia 31.25 11.28 69 449473 19583 55822942
Drug use disorder 31.14 11.28 95 449447 4574 55837951
Troponin increased 31.08 11.28 15 449527 8620 55833905
Hyperreflexia 31.02 11.28 3 449539 5247 55837278
Acute pulmonary oedema 30.89 11.28 11 449531 7586 55834939
Eyelid oedema 30.79 11.28 20 449522 9748 55832777
Diverticulum 30.57 11.28 26 449516 11040 55831485
Dermatitis atopic 30.51 11.28 14 449528 8285 55834240
Muscle tightness 30.50 11.28 25 449517 10811 55831714
Jaundice cholestatic 30.48 11.28 4 449538 5515 55837010
Skin burning sensation 30.37 11.28 26 449516 11005 55831520
Infiltration anaesthesia 30.36 11.28 19 449523 173 55842352
Hair follicle tumour benign 30.35 11.28 25 449517 362 55842163
Bronchitis chronic 30.29 11.28 85 449457 3903 55838622
Klebsiella infection 30.25 11.28 12 449530 7744 55834781
Device leakage 30.02 11.28 7 449535 6368 55836157
Eosinophil count increased 30.01 11.28 20 449522 9617 55832908
Sudden death 29.94 11.28 20 449522 9605 55832920
Lower gastrointestinal haemorrhage 29.92 11.28 10 449532 7177 55835348
Drug specific antibody 29.89 11.28 57 449485 2023 55840502
Migraine 29.87 11.28 500 449042 86297 55756228
Oliguria 29.87 11.28 15 449527 8425 55834100
Bradyphrenia 29.76 11.28 8 449534 6612 55835913
Coeliac disease 29.76 11.28 162 449380 10177 55832348
Renal injury 29.68 11.28 17 449525 8870 55833655
Myopathy toxic 29.45 11.28 27 449515 455 55842070
Haemodynamic instability 29.18 11.28 15 449527 8314 55834211
Toxic encephalopathy 29.02 11.28 6 449536 5932 55836593
Oesophagitis 28.97 11.28 42 449500 14015 55828510
Deafness neurosensory 28.95 11.28 93 449449 4605 55837920
Haemorrhoids 28.91 11.28 75 449467 20131 55822394
Pulseless electrical activity 28.85 11.28 10 449532 7014 55835511
Musculoskeletal chest pain 28.80 11.28 72 449470 19569 55822956
Product substitution issue 28.75 11.28 45 449497 14554 55827971
Metabolic encephalopathy 28.75 11.28 4 449538 5276 55837249
Cold sweat 28.68 11.28 27 449515 10916 55831609
Pancreatic carcinoma 28.57 11.28 11 449531 7230 55835295
Chromaturia 28.54 11.28 49 449493 15276 55827249
White blood cell count abnormal 28.52 11.28 6 449536 5861 55836664
Fear 28.38 11.28 47 449495 14861 55827664
Bronchospasm 28.36 11.28 51 449491 15618 55826907
Neck deformity 28.31 11.28 55 449487 1980 55840545
Unintended pregnancy 28.10 11.28 4 449538 5187 55837338
Bradykinesia 28.09 11.28 3 449539 4851 55837674
Thyroid neoplasm 27.99 11.28 80 449462 3713 55838812
Transplant rejection 27.86 11.28 23 449519 9911 55832614
Stress cardiomyopathy 27.76 11.28 16 449526 8320 55834205
Device use error 27.75 11.28 5 449537 5451 55837074
Product storage error 27.71 11.28 39 449503 13174 55829351
Pathological fracture 27.70 11.28 15 449527 8074 55834451
Failure to thrive 27.60 11.28 9 449533 6561 55835964
Vasculitic rash 27.58 11.28 42 449500 1238 55841287
Injection site reaction 27.51 11.28 587 448955 52660 55789865
Drug level decreased 27.43 11.28 11 449531 7053 55835472
Thirst 27.19 11.28 29 449513 11061 55831464
Medication error 27.16 11.28 212 449330 42123 55800402
Hyperventilation 27.00 11.28 6 449536 5642 55836883
Malaise 26.96 11.28 2550 446992 365310 55477215
Electrocardiogram U-wave abnormality 26.93 11.28 10 449532 22 55842503
Gingivitis 26.83 11.28 14 449528 7695 55834830
Fungal infection 26.79 11.28 154 449388 32839 55809686
Fistula 26.75 11.28 19 449523 8836 55833689
Wrist surgery 26.73 11.28 33 449509 793 55841732
Thinking abnormal 26.68 11.28 24 449518 9917 55832608
Urticarial vasculitis 26.67 11.28 30 449512 651 55841874
Blood calcium increased 26.66 11.28 16 449526 8138 55834387
Pain in extremity 26.54 11.28 2738 446804 294693 55547832
Large intestine polyp 26.33 11.28 14 449528 7613 55834912
Histoplasmosis disseminated 26.32 11.28 42 449500 1290 55841235
Large intestine perforation 26.25 11.28 15 449527 7836 55834689
Application site erythema 26.22 11.28 3 449539 4597 55837928
Optical coherence tomography abnormal 26.21 11.28 9 449533 14 55842511
Mass excision 26.20 11.28 21 449521 292 55842233
Sneezing 26.11 11.28 53 449489 15507 55827018
Product physical issue 26.09 11.28 3 449539 4579 55837946
Proctalgia 26.04 11.28 6 449536 5503 55837022
Device occlusion 25.89 11.28 10 449532 6559 55835966
Head discomfort 25.65 11.28 35 449507 11979 55830546
Affect lability 25.36 11.28 26 449516 10099 55832426
Productive cough 25.33 11.28 307 449235 55925 55786600
Sinus disorder 25.27 11.28 83 449459 20651 55821874
Hypercapnia 25.21 11.28 5 449537 5091 55837434
Peripheral sensory neuropathy 25.16 11.28 12 449530 6944 55835581
Escherichia infection 25.06 11.28 34 449508 11665 55830860
Tinnitus 25.06 11.28 139 449403 29903 55812622
Spinal fracture 25.03 11.28 59 449483 16365 55826160
Venoocclusive liver disease 24.91 11.28 3 449539 4418 55838107
Peritonitis 24.86 11.28 58 449484 16144 55826381
Pulmonary haemosiderosis 24.80 11.28 9 449533 18 55842507
Cartilage atrophy 24.74 11.28 16 449526 155 55842370
Eosinophilia 24.72 11.28 80 449462 19997 55822528
Hepatic necrosis 24.72 11.28 6 449536 5310 55837215
Mycobacterium tuberculosis complex test positive 24.68 11.28 51 449491 1921 55840604
Sensory loss 24.67 11.28 21 449521 8914 55833611
Mean cell haemoglobin decreased 24.66 11.28 84 449458 4288 55838237
Major depression 24.63 11.28 15 449527 7569 55834956
Lung infiltration 24.61 11.28 45 449497 13693 55828832
Arteriosclerosis coronary artery 24.58 11.28 16 449526 7789 55834736
Blood magnesium increased 24.52 11.28 65 449477 2886 55839639
Septic shock 24.50 11.28 340 449202 60495 55782030
Cutaneous coccidioidomycosis 24.48 11.28 9 449533 19 55842506
Cardiomegaly 24.43 11.28 60 449482 16407 55826118
Disease susceptibility 24.42 11.28 17 449525 188 55842337
Post transplant lymphoproliferative disorder 24.38 11.28 4 449538 4668 55837857
Injection site haemorrhage 24.30 11.28 93 449449 22108 55820417
Neoplasm malignant 24.17 11.28 326 449216 26729 55815796
Apathy 24.11 11.28 17 449525 7937 55834588
Accident 24.01 11.28 97 449445 5379 55837146
Hydronephrosis 23.99 11.28 23 449519 9219 55833306
Blood glucose fluctuation 23.99 11.28 3 449539 4292 55838233
Confusional state 23.89 11.28 1389 448153 206766 55635759
Long QT syndrome 23.80 11.28 66 449476 3010 55839515
Immune thrombocytopenia 23.79 11.28 25 449517 9600 55832925
Toxic epidermal necrolysis 23.70 11.28 93 449449 21949 55820576
Coma scale abnormal 23.59 11.28 5 449537 4858 55837667
Hyperthermia 23.46 11.28 19 449523 8266 55834259
Bone cyst 23.45 11.28 52 449490 2058 55840467
Partial seizures 23.33 11.28 7 449535 5383 55837142
Pregnancy with contraceptive device 23.29 11.28 3 449539 4196 55838329
Palindromic rheumatism 23.27 11.28 17 449525 204 55842321
Menstruation irregular 23.19 11.28 11 449531 6385 55836140
Oropharyngeal pain 23.18 11.28 501 449041 83287 55759238
Somnambulism 23.18 11.28 6 449536 5086 55837439
Heart rate abnormal 23.18 11.28 4 449538 4499 55838026
Hyperuricaemia 23.06 11.28 6 449536 5067 55837458
Ankle operation 23.05 11.28 38 449504 1200 55841325
Myocarditis 23.05 11.28 22 449520 8836 55833689
Product adhesion issue 23.04 11.28 4 449538 4479 55838046
Diffuse alopecia 23.02 11.28 27 449515 614 55841911
Pelvic pain 22.97 11.28 37 449505 11830 55830695
Ocular hyperaemia 22.83 11.28 94 449448 21885 55820640
Foetal exposure during pregnancy 22.82 11.28 167 449375 33656 55808869
Initial insomnia 22.82 11.28 8 449534 5571 55836954
Ischaemia 22.75 11.28 4 449538 4439 55838086
Skin ulcer 22.73 11.28 434 449108 38174 55804351
Blood thyroid stimulating hormone increased 22.72 11.28 12 449530 6551 55835974
Alanine aminotransferase abnormal 22.69 11.28 81 449461 4234 55838291
Nail disorder 22.67 11.28 163 449379 11288 55831237
Lupus myocarditis 22.64 11.28 11 449531 57 55842468
Facial paralysis 22.62 11.28 45 449497 13266 55829259
Hallucinations, mixed 22.62 11.28 4 449538 4420 55838105
Neutrophil count increased 22.62 11.28 54 449488 14911 55827614
Lyme disease 22.42 11.28 63 449479 2895 55839630
Oedema 22.33 11.28 491 449051 81429 55761096
Blood loss anaemia 22.31 11.28 20 449522 8277 55834248
Polyneuropathy 22.28 11.28 44 449498 13006 55829519
Posterior reversible encephalopathy syndrome 22.26 11.28 60 449482 15900 55826625
Cholangitis 22.21 11.28 6 449536 4943 55837582
Drug level above therapeutic 22.18 11.28 4 449538 4358 55838167
Duodenal ulcer 22.08 11.28 15 449527 7140 55835385
Procedural pain 22.07 11.28 62 449480 16209 55826316
Metabolic disorder 22.05 11.28 8 449534 5453 55837072
Weight fluctuation 22.01 11.28 19 449523 8009 55834516
Lung disorder 21.98 11.28 563 448979 52034 55790491
Skin reaction 21.97 11.28 179 449363 12884 55829641
Hypomania 21.90 11.28 6 449536 4896 55837629
Aplasia 21.82 11.28 3 449539 3993 55838532
Neuralgia 21.81 11.28 106 449436 23589 55818936
Wound infection 21.80 11.28 201 449341 14992 55827533
Femoral neck fracture 21.78 11.28 18 449524 7753 55834772
COVID-19 treatment 21.76 11.28 13 449529 108 55842417
Nocardiosis 21.74 11.28 46 449496 1762 55840763
Respiratory acidosis 21.74 11.28 11 449531 6152 55836373
Allergy to chemicals 21.66 11.28 55 449487 2378 55840147
Lung neoplasm malignant 21.64 11.28 69 449473 17327 55825198
Micturition urgency 21.49 11.28 23 449519 8758 55833767
Retinal degeneration 21.45 11.28 30 449512 817 55841708
Dyslipidaemia 21.44 11.28 12 449530 6341 55836184
Hepatic lesion 21.42 11.28 4 449538 4251 55838274
Hypercalcaemia 21.41 11.28 303 449239 25108 55817417
Gallbladder disorder 21.39 11.28 69 449473 17265 55825260
Intestinal sepsis 21.39 11.28 18 449524 269 55842256
Expired product administered 21.31 11.28 9 449533 5593 55836932
Granulocytopenia 21.28 11.28 8 449534 5336 55837189
Diabetic eye disease 21.28 11.28 14 449528 140 55842385
Application site pain 21.27 11.28 3 449539 3917 55838608
Rash papular 21.27 11.28 47 449495 13336 55829189
Blood pressure inadequately controlled 21.24 11.28 5 449537 4519 55838006
Nephropathy toxic 21.24 11.28 22 449520 8505 55834020
Left ventricular dysfunction 21.23 11.28 35 449507 11088 55831437
Blood urine present 21.22 11.28 48 449494 13507 55829018
Fundoscopy abnormal 21.15 11.28 7 449535 9 55842516
Eyelid ptosis 21.03 11.28 13 449529 6506 55836019
Stress at work 20.99 11.28 35 449507 1116 55841409
Internal haemorrhage 20.96 11.28 6 449536 4758 55837767
Rhinitis allergic 20.96 11.28 22 449520 8452 55834073
Atrial septal defect 20.95 11.28 13 449529 6493 55836032
Skin irritation 20.85 11.28 22 449520 8433 55834092
Cushingoid 20.78 11.28 115 449427 7269 55835256
Chorioretinitis 20.66 11.28 24 449518 540 55841985
Generalised oedema 20.61 11.28 54 449488 14447 55828078
Therapy change 20.58 11.28 9 449533 5479 55837046
Tender joint count 20.56 11.28 12 449530 95 55842430
Restless legs syndrome 20.54 11.28 68 449474 16879 55825646
Infective exacerbation of bronchiectasis 20.54 11.28 19 449523 324 55842201
Body tinea 20.52 11.28 39 449503 1381 55841144
Respiratory syncytial virus infection 20.41 11.28 9 449533 5452 55837073
Antiphospholipid syndrome 20.38 11.28 42 449500 1579 55840946
Product residue present 20.37 11.28 3 449539 3792 55838733
Neuropsychiatric lupus 20.33 11.28 15 449527 183 55842342
Hypertonia 20.28 11.28 4 449538 4088 55838437
Wrong product administered 20.19 11.28 10 449532 5662 55836863
Tenderness 20.18 11.28 248 449294 19907 55822618
Ketoacidosis 20.16 11.28 4 449538 4071 55838454
Gastric ulcer 20.15 11.28 102 449440 22461 55820064
Dermatitis contact 20.10 11.28 28 449514 9499 55833026
Limb operation 20.09 11.28 69 449473 3537 55838988
Hypovolaemic shock 19.85 11.28 9 449533 5364 55837161
Cardiac failure acute 19.82 11.28 25 449517 8848 55833677
Diverticulitis 19.75 11.28 399 449143 35453 55807072
Nystagmus 19.66 11.28 11 449531 5814 55836711
Functional gastrointestinal disorder 19.62 11.28 71 449471 3736 55838789
Synovial fluid analysis 19.59 11.28 46 449496 1892 55840633
Product preparation error 19.54 11.28 7 449535 4809 55837716
Gastric cancer 19.52 11.28 4 449538 3979 55838546
Hypokinesia 19.51 11.28 46 449496 12757 55829768
Incoherent 19.50 11.28 5 449537 4264 55838261
Electrocardiogram ST segment elevation 19.46 11.28 3 449539 3666 55838859
Non-small cell lung cancer 19.39 11.28 3 449539 3655 55838870
Amylase increased 19.33 11.28 11 449531 5760 55836765
Atrioventricular block 19.25 11.28 16 449526 6871 55835654
Injection site swelling 19.21 11.28 239 449303 43339 55799186
Rib fracture 19.19 11.28 90 449452 20219 55822306
Atelectasis 19.18 11.28 84 449458 19224 55823301
Cerebral atrophy 19.17 11.28 7 449535 4753 55837772
Vitamin D deficiency 19.13 11.28 43 449499 12127 55830398
Viral infection 19.11 11.28 163 449379 31783 55810742
Peritonitis bacterial 18.99 11.28 7 449535 4726 55837799
Extra dose administered 18.96 11.28 10 449532 5463 55837062
Cutaneous sarcoidosis 18.93 11.28 19 449523 360 55842165
Vaginal discharge 18.91 11.28 13 449529 6150 55836375
Butterfly rash 18.91 11.28 39 449503 1467 55841058
Salt craving 18.86 11.28 11 449531 87 55842438
Cerebral ischaemia 18.84 11.28 13 449529 6137 55836388
Apnoea 18.83 11.28 18 449524 7224 55835301
Hypertensive crisis 18.66 11.28 54 449488 13982 55828543
Prescribed underdose 18.66 11.28 249 449293 20368 55822157
Bronchopleural fistula 18.63 11.28 15 449527 210 55842315
Insomnia 18.61 11.28 1300 448242 190560 55651965
Pustular psoriasis 18.59 11.28 78 449464 4400 55838125
Clostridial infection 18.58 11.28 5 449537 4130 55838395
Depressive symptom 18.55 11.28 3 449539 3538 55838987
Food allergy 18.55 11.28 26 449516 8798 55833727
Respiration abnormal 18.54 11.28 11 449531 5630 55836895
Palmoplantar pustulosis 18.52 11.28 21 449521 460 55842065
Skin haemorrhage 18.48 11.28 24 449518 8389 55834136
Gastric ulcer haemorrhage 18.47 11.28 7 449535 4646 55837879
Eructation 18.43 11.28 20 449522 7568 55834957
Intestinal ischaemia 18.42 11.28 17 449525 6938 55835587
Exercise tolerance decreased 18.38 11.28 9 449533 5129 55837396
Application site pruritus 18.37 11.28 4 449538 3815 55838710
Oral discomfort 18.35 11.28 122 449420 8233 55834292
Tricuspid valve incompetence 18.35 11.28 50 449492 13203 55829322
Colon cancer 18.33 11.28 30 449512 9531 55832994
Unevaluable event 18.33 11.28 269 449273 47418 55795107
Urosepsis 18.31 11.28 70 449472 16646 55825879
Eczema 18.19 11.28 128 449414 26025 55816500
Eye irritation 18.17 11.28 84 449458 18944 55823581
Faeces soft 18.06 11.28 8 449534 4834 55837691
Pruritus allergic 18.03 11.28 35 449507 1259 55841266
Toxic skin eruption 18.03 11.28 42 449500 11697 55830828
Cerebellar syndrome 18.02 11.28 3 449539 3464 55839061
Drug screen positive 18.00 11.28 3 449539 3461 55839064
Brain neoplasm 17.98 11.28 5 449537 4041 55838484
Treatment noncompliance 17.96 11.28 170 449372 32453 55810072
Tuberculosis 17.95 11.28 150 449392 10879 55831646
Limb deformity 17.89 11.28 70 449472 3825 55838700
Atrioventricular block second degree 17.80 11.28 4 449538 3732 55838793
Hepatic enzyme abnormal 17.80 11.28 85 449457 5070 55837455
Fibrin D dimer increased 17.79 11.28 7 449535 4540 55837985
Mood swings 17.79 11.28 71 449471 16676 55825849
Ovarian cyst 17.78 11.28 60 449482 14806 55827719
Bone disorder 17.67 11.28 236 449306 19307 55823218
Gingival pain 17.66 11.28 15 449527 6373 55836152
Contraindication to medical treatment 17.60 11.28 24 449518 638 55841887
Obsessive-compulsive disorder 17.59 11.28 4 449538 3702 55838823
Middle lobe syndrome 17.53 11.28 8 449534 35 55842490
Multiple-drug resistance 17.50 11.28 5 449537 3969 55838556
Breast cancer female 17.49 11.28 46 449496 12292 55830233
Dry mouth 17.44 11.28 385 449157 63820 55778705
Cytopenia 17.43 11.28 32 449510 9723 55832802
Extradural abscess 17.43 11.28 27 449515 808 55841717
Atrioventricular block first degree 17.37 11.28 17 449525 6748 55835777
Atrial flutter 17.37 11.28 29 449513 9140 55833385
Bacterial test positive 17.32 11.28 9 449533 4959 55837566
Haemolysis 17.32 11.28 15 449527 6313 55836212
Drug tolerance 17.31 11.28 94 449448 5900 55836625
Bipolar disorder 17.30 11.28 21 449521 7559 55834966
Hypoxic-ischaemic encephalopathy 17.30 11.28 5 449537 3940 55838585
Coronary artery stenosis 17.28 11.28 7 449535 4461 55838064
Exostosis 17.25 11.28 189 449353 14754 55827771
Gastroenteritis 17.22 11.28 119 449423 24293 55818232
Device failure 17.16 11.28 12 449530 5627 55836898
Colitis ulcerative 17.15 11.28 119 449423 24272 55818253
Uterine leiomyoma 17.12 11.28 25 449517 8317 55834208
Obesity 17.08 11.28 263 449279 22185 55820340
West Nile viral infection 17.04 11.28 18 449524 363 55842162
Infusion site swelling 16.99 11.28 23 449519 7898 55834627
Haemoglobin increased 16.98 11.28 3 449539 3317 55839208
Affective disorder 16.95 11.28 12 449530 5591 55836934
Vitamin D decreased 16.95 11.28 29 449513 9054 55833471
Skin toxicity 16.91 11.28 6 449536 4147 55838378
Pneumonia fungal 16.86 11.28 9 449533 4884 55837641
Mitral valve incompetence 16.83 11.28 81 449461 18072 55824453
Pulmonary mass 16.81 11.28 243 449299 20227 55822298
Fluid intake reduced 16.74 11.28 3 449539 3284 55839241
Infected seroma 16.74 11.28 10 449532 83 55842442
Spinal meningioma benign 16.72 11.28 11 449531 110 55842415
Androgenetic alopecia 16.71 11.28 12 449530 140 55842385
Drug effective for unapproved indication 16.67 11.28 52 449490 2534 55839991
Joint dislocation 16.63 11.28 196 449346 15577 55826948
Hereditary angioedema 16.62 11.28 18 449524 6817 55835708
Systemic infection 16.62 11.28 3 449539 3266 55839259
Respiratory rate decreased 16.57 11.28 3 449539 3259 55839266
Breast cancer stage II 16.56 11.28 13 449529 5745 55836780
Femur fracture 16.53 11.28 421 449121 38874 55803651
Infectious crystalline keratopathy 16.53 11.28 6 449536 12 55842513
Dermatitis exfoliative 16.50 11.28 11 449531 5288 55837237
Larynx irritation 16.48 11.28 11 449531 113 55842412
Venous thrombosis 16.42 11.28 8 449534 4572 55837953
Bladder cancer 16.35 11.28 9 449533 4801 55837724
Tenosynovitis stenosans 16.34 11.28 52 449490 2562 55839963
Antinuclear antibody positive 16.32 11.28 102 449440 6739 55835786
Haemolytic anaemia 16.24 11.28 33 449509 9652 55832873
Anaphylactoid reaction 16.22 11.28 4 449538 3502 55839023
Cranial nerve injury 16.22 11.28 6 449536 13 55842512
Coloboma 16.17 11.28 10 449532 89 55842436
Infection reactivation 16.16 11.28 30 449512 1043 55841482
Post-traumatic stress disorder 16.16 11.28 8 449534 4530 55837995
Drooling 16.13 11.28 4 449538 3490 55839035
Infective tenosynovitis 16.06 11.28 15 449527 259 55842266
Autoimmune haemolytic anaemia 16.06 11.28 7 449535 4269 55838256
Catheterisation cardiac 16.05 11.28 7 449535 4268 55838257
Coronary artery occlusion 16.02 11.28 23 449519 7706 55834819
Facet joint syndrome 15.93 11.28 100 449442 6617 55835908
Symptom masked 15.92 11.28 23 449519 646 55841879
Humerus fracture 15.91 11.28 25 449517 8072 55834453
Urine abnormality 15.89 11.28 18 449524 6681 55835844
Sinus congestion 15.87 11.28 68 449474 15656 55826869
Blood lactic acid increased 15.85 11.28 15 449527 6049 55836476
Brain natriuretic peptide increased 15.84 11.28 9 449533 4717 55837808
Uterine cancer 15.79 11.28 8 449534 4471 55838054
Blood creatine increased 15.76 11.28 11 449531 5162 55837363
Heparin-induced thrombocytopenia 15.66 11.28 7 449535 4207 55838318
Retinal haemorrhage 15.63 11.28 9 449533 4682 55837843
Abortion incomplete 15.62 11.28 3 449539 3124 55839401
Refusal of treatment by patient 15.55 11.28 11 449531 5127 55837398
Retinal deposits 15.55 11.28 9 449533 70 55842455
Exposure to toxic agent 15.52 11.28 5 449537 3673 55838852
Pathogen resistance 15.50 11.28 15 449527 5985 55836540
Hepatitis cholestatic 15.47 11.28 17 449525 6397 55836128
Serum ferritin increased 15.46 11.28 13 449529 5552 55836973
Angina unstable 15.46 11.28 19 449523 6802 55835723
Cytomegalovirus viraemia 15.45 11.28 11 449531 5109 55837416
Forced expiratory volume decreased 15.44 11.28 9 449533 4651 55837874
Nerve injury 15.37 11.28 30 449512 8907 55833618
Pre-existing condition improved 15.35 11.28 22 449520 7376 55835149
Gangrene 15.32 11.28 13 449529 5527 55836998
Bursitis 15.20 11.28 307 449235 27275 55815250
Lymphadenopathy 15.18 11.28 194 449348 35014 55807511
Hepatic cancer 15.11 11.28 7 449535 4120 55838405
Systemic inflammatory response syndrome 15.08 11.28 12 449530 5266 55837259
Autoimmune hepatitis 15.05 11.28 25 449517 7896 55834629
Osteonecrosis 15.01 11.28 116 449426 23099 55819426
Hyperlipidaemia 14.99 11.28 84 449458 18025 55824500
Performance status decreased 14.97 11.28 4 449538 3319 55839206
Cerebral haematoma 14.97 11.28 4 449538 3319 55839206
Maternal exposure timing unspecified 14.96 11.28 84 449458 5339 55837186
White blood cells urine positive 14.91 11.28 10 449532 4792 55837733
Peripheral coldness 14.90 11.28 42 449500 10969 55831556
Localised oedema 14.80 11.28 11 449531 4998 55837527
Cornea verticillata 14.80 11.28 10 449532 105 55842420
Adrenal insufficiency 14.80 11.28 191 449351 15506 55827019
Blood immunoglobulin E increased 14.79 11.28 3 449539 3006 55839519
Placenta accreta 14.78 11.28 13 449529 207 55842318
Metastases to peritoneum 14.75 11.28 3 449539 3001 55839524
Paradoxical drug reaction 14.75 11.28 6 449536 3814 55838711
Potentiating drug interaction 14.73 11.28 7 449535 4059 55838466
Adjustment disorder with depressed mood 14.72 11.28 80 449462 5023 55837502
Anterior chamber cleavage syndrome 14.67 11.28 12 449530 172 55842353
Bronchitis 14.63 11.28 740 448802 111571 55730954
Aortic arteriosclerosis 14.63 11.28 14 449528 5616 55836909
Portal hypertension 14.62 11.28 5 449537 3536 55838989
Infusion site extravasation 14.61 11.28 27 449515 8183 55834342
Catheter site infection 14.56 11.28 9 449533 4505 55838020
Muscle haemorrhage 14.55 11.28 3 449539 2972 55839553
Tooth extraction 14.55 11.28 34 449508 9459 55833066
Lupus vulgaris 14.54 11.28 41 449501 1888 55840637
Culture urine positive 14.53 11.28 5 449537 3523 55839002
Emotional disorder 14.45 11.28 50 449492 12245 55830280
Blindness 14.41 11.28 87 449455 18334 55824191
Anticoagulation drug level increased 14.39 11.28 12 449530 177 55842348
Gastritis erosive 14.34 11.28 14 449528 5563 55836962
Neoplasm 14.33 11.28 18 449524 6383 55836142
Blood potassium increased 14.32 11.28 80 449462 17181 55825344
Adenoiditis 14.29 11.28 7 449535 37 55842488
Mean cell haemoglobin concentration decreased 14.29 11.28 4 449538 3219 55839306
Appetite disorder 14.29 11.28 19 449523 6574 55835951
Peripheral ischaemia 14.26 11.28 9 449533 4454 55838071
Decubitus ulcer 14.20 11.28 36 449506 9739 55832786
Natural killer-cell leukaemia 14.19 11.28 10 449532 113 55842412
Diaphragm muscle weakness 14.17 11.28 6 449536 21 55842504
Micrognathia 14.17 11.28 14 449528 260 55842265
Neck surgery 14.15 11.28 38 449504 1700 55840825
Transaminases increased 14.15 11.28 154 449388 28616 55813909
Formication 14.13 11.28 7 449535 3963 55838562
Granulomatous dermatitis 14.11 11.28 10 449532 114 55842411
Gonorrhoea 14.04 11.28 10 449532 115 55842410
Gastric disorder 14.03 11.28 356 449186 32854 55809671
Disease complication 13.99 11.28 3 449539 2892 55839633
Fracture delayed union 13.97 11.28 46 449496 2307 55840218
Mixed connective tissue disease 13.91 11.28 18 449524 454 55842071
Injection site induration 13.90 11.28 30 449512 8585 55833940
Bursitis infective 13.88 11.28 32 449510 1300 55841225
End stage renal disease 13.88 11.28 17 449525 6094 55836431
Cardiopulmonary failure 13.86 11.28 5 449537 3420 55839105
Areflexia 13.86 11.28 3 449539 2872 55839653
Blood chloride decreased 13.85 11.28 13 449529 5264 55837261
Hypergammaglobulinaemia 13.85 11.28 18 449524 456 55842069
Monocyte count abnormal 13.75 11.28 12 449530 189 55842336
Pleuritic pain 13.71 11.28 100 449442 6957 55835568
Exposed bone in jaw 13.67 11.28 3 449539 2845 55839680
Urine leukocyte esterase positive 13.65 11.28 4 449538 3124 55839401
Pleuropericarditis 13.62 11.28 13 449529 231 55842294
Increased appetite 13.62 11.28 31 449511 8704 55833821
Breast pain 13.61 11.28 27 449515 7967 55834558
Creatinine urine abnormal 13.58 11.28 7 449535 42 55842483
Lip dry 13.54 11.28 128 449414 9612 55832913
Heart rate decreased 13.54 11.28 234 449308 40193 55802332
Headache 13.54 11.28 4123 445419 554921 55287604
Photopsia 13.49 11.28 8 449534 4095 55838430
Electrocardiogram abnormal 13.44 11.28 28 449514 8116 55834409
Cryptococcal meningoencephalitis 13.44 11.28 9 449533 93 55842432
Herpes zoster reactivation 13.44 11.28 8 449534 66 55842459
Incorrect dosage administered 13.44 11.28 38 449504 1753 55840772
Iodine allergy 13.43 11.28 23 449519 750 55841775
Inflammatory marker increased 13.42 11.28 89 449453 6001 55836524
Dermatitis bullous 13.39 11.28 25 449517 7548 55834977
Phlebitis 13.38 11.28 18 449524 6198 55836327
Congenital osteodystrophy 13.38 11.28 6 449536 25 55842500
Occult blood positive 13.37 11.28 5 449537 3346 55839179
Drug level below therapeutic 13.37 11.28 9 449533 4304 55838221
Vitamin B12 decreased 13.30 11.28 4 449538 3071 55839454
Bowel movement irregularity 13.28 11.28 10 449532 4513 55838012
Catheter site pain 13.25 11.28 9 449533 4284 55838241
Prescribed overdose 13.25 11.28 251 449291 22045 55820480
Ventricular fibrillation 13.24 11.28 44 449498 10908 55831617
Snoring 13.23 11.28 6 449536 3575 55838950
BK virus infection 13.23 11.28 4 449538 3060 55839465
Coombs positive haemolytic anaemia 13.21 11.28 15 449527 329 55842196
Malabsorption 13.21 11.28 7 449535 3814 55838711
Pseudomonas infection 13.20 11.28 39 449503 10032 55832493
Hereditary motor and sensory neuropathy 13.20 11.28 9 449533 96 55842429
Blood phosphorus increased 13.17 11.28 3 449539 2773 55839752
Polycystic ovaries 13.13 11.28 5 449537 3309 55839216
Urine analysis abnormal 13.13 11.28 11 449531 4706 55837819
Spinal compression fracture 13.13 11.28 57 449485 13077 55829448
Gastrointestinal sounds abnormal 13.11 11.28 7 449535 3798 55838727
Decreased interest 13.11 11.28 4 449538 3042 55839483
Parosmia 13.10 11.28 11 449531 4700 55837825
Gestational diabetes 13.08 11.28 28 449514 8036 55834489
Thoracic vertebral fracture 13.07 11.28 9 449533 4254 55838271
Multiple system atrophy 13.05 11.28 12 449530 203 55842322
Rheumatoid factor 13.05 11.28 8 449534 70 55842455
Intervertebral disc compression 13.02 11.28 26 449516 955 55841570
Antinuclear antibody negative 13.00 11.28 12 449530 204 55842321
Tooth loss 12.99 11.28 19 449523 6318 55836207
Cardiovascular disorder 12.99 11.28 44 449498 10845 55831680
Anaphylactic shock 12.97 11.28 111 449431 21629 55820896
Microtia 12.94 11.28 16 449526 385 55842140
Ventricular extrasystoles 12.91 11.28 44 449498 10826 55831699
Gingival swelling 12.90 11.28 8 449534 3998 55838527
Gout 12.86 11.28 52 449490 12169 55830356
Sluggishness 12.85 11.28 11 449531 4657 55837868
Chronic cutaneous lupus erythematosus 12.80 11.28 13 449529 250 55842275
Kidney transplant rejection 12.78 11.28 9 449533 4204 55838321
Facial paresis 12.72 11.28 5 449537 3245 55839280
Haematocrit decreased 12.72 11.28 212 449330 36617 55805908
No adverse event 12.68 11.28 209 449333 36165 55806360
Escherichia urinary tract infection 12.65 11.28 45 449497 10930 55831595
Varicose vein 12.63 11.28 11 449531 4618 55837907
Dysmenorrhoea 12.63 11.28 6 449536 3480 55839045
Monoplegia 12.63 11.28 4 449538 2970 55839555
Foetal movement disorder 12.61 11.28 4 449538 4 55842521
Red blood cell count decreased 12.57 11.28 211 449331 36406 55806119
Central nervous system lupus 12.57 11.28 16 449526 397 55842128
Loss of employment 12.53 11.28 39 449503 1898 55840627
Hepatomegaly 12.49 11.28 47 449495 11228 55831297
Ocular sarcoidosis 12.47 11.28 7 449535 51 55842474
Bacterial infection 12.46 11.28 84 449458 17246 55825279
Inadequate analgesia 12.45 11.28 3 449539 2668 55839857
Neutrophil count abnormal 12.44 11.28 3 449539 2667 55839858
Hepatitis fulminant 12.42 11.28 5 449537 3199 55839326
Chronic myeloid leukaemia 12.38 11.28 3 449539 2659 55839866
Erythematotelangiectatic rosacea 12.38 11.28 5 449537 15 55842510
Cystic fibrosis 12.37 11.28 6 449536 3438 55839087
Renal pain 12.36 11.28 18 449524 5995 55836530
Latent tuberculosis 12.34 11.28 46 449496 2456 55840069
Eye movement disorder 12.34 11.28 12 449530 4777 55837748
Arterial occlusive disease 12.34 11.28 15 449527 5395 55837130
Thyroid function test abnormal 12.30 11.28 6 449536 3427 55839098
Mycobacterial infection 12.29 11.28 36 449506 1694 55840831
Thrombophlebitis 12.28 11.28 9 449533 4118 55838407
Double stranded DNA antibody positive 12.26 11.28 14 449528 309 55842216
Sensation of foreign body 12.25 11.28 9 449533 4113 55838412
Visual field defect 12.24 11.28 87 449455 6002 55836523
Vascular device infection 12.23 11.28 16 449526 5574 55836951
Incorrect drug administration rate 12.21 11.28 5 449537 3165 55839360
Hepatitis C 12.20 11.28 16 449526 5570 55836955
Pulse absent 12.17 11.28 13 449529 4954 55837571
Vertigo positional 12.16 11.28 3 449539 2626 55839899
Acute vestibular syndrome 12.14 11.28 5 449537 16 55842509
Trigeminal neuralgia 12.14 11.28 6 449536 3401 55839124
Pneumonia bacterial 12.11 11.28 29 449513 7999 55834526
Flank pain 12.10 11.28 66 449476 14259 55828266
Blepharospasm 12.08 11.28 6 449536 3392 55839133
Rhinitis 12.07 11.28 34 449508 8882 55833643
Lupus enteritis 12.04 11.28 7 449535 55 55842470
Urinary tract infection enterococcal 12.02 11.28 3 449539 2606 55839919
Microsporidia infection 12.01 11.28 13 449529 270 55842255
Polyp 12.01 11.28 18 449524 5924 55836601
Skin abrasion 11.99 11.28 32 449510 8509 55834016
Oral lichen planus 11.97 11.28 19 449523 581 55841944
Scleritis 11.96 11.28 60 449482 3651 55838874
Catheter site erythema 11.95 11.28 9 449533 4061 55838464
Retinogram abnormal 11.91 11.28 10 449532 149 55842376
Paronychia 11.90 11.28 13 449529 4905 55837620
Dizziness postural 11.90 11.28 21 449521 6477 55836048
Facial bones fracture 11.89 11.28 6 449536 3361 55839164
Allergy to vaccine 11.87 11.28 11 449531 188 55842337
Monocyte count increased 11.83 11.28 88 449454 6160 55836365
Epigastric discomfort 11.83 11.28 88 449454 6160 55836365
Laryngeal oedema 11.82 11.28 15 449527 5295 55837230
C-reactive protein 11.80 11.28 39 449503 1960 55840565
Intrauterine infection 11.79 11.28 9 449533 116 55842409
Maternal drugs affecting foetus 11.74 11.28 14 449528 5079 55837446
Petit mal epilepsy 11.73 11.28 7 449535 3571 55838954
Synovial disorder 11.73 11.28 27 449515 1096 55841429
Biliary dyskinesia 11.71 11.28 3 449539 2560 55839965
Blood chloride increased 11.70 11.28 3 449539 2559 55839966
C-reactive protein decreased 11.69 11.28 23 449519 836 55841689
Choking 11.68 11.28 35 449507 8962 55833563
Invasive ductal breast carcinoma 11.67 11.28 23 449519 6803 55835722
Cytomegalovirus test positive 11.65 11.28 4 449538 2822 55839703
Injection site bruising 11.64 11.28 227 449315 38294 55804231
DNA antibody 11.64 11.28 6 449536 36 55842489
Complement factor C3 decreased 11.60 11.28 13 449529 281 55842244
Overweight 11.56 11.28 6 449536 3308 55839217
Genital abscess 11.56 11.28 12 449530 237 55842288
Venous thrombosis limb 11.54 11.28 4 449538 2805 55839720
Staphylococcal sepsis 11.52 11.28 26 449516 7323 55835202
Psychiatric symptom 11.51 11.28 13 449529 4831 55837694
Blood pressure abnormal 11.50 11.28 63 449479 13597 55828928
Hypertelorism 11.49 11.28 16 449526 434 55842091
Illness 11.48 11.28 200 449342 34311 55808214
Pulmonary haemorrhage 11.47 11.28 23 449519 6760 55835765
Screaming 11.47 11.28 5 449537 3049 55839476
Hysterectomy 11.46 11.28 33 449509 8558 55833967
Ocular discomfort 11.42 11.28 8 449534 3747 55838778
Abdominal hernia 11.41 11.28 12 449530 4607 55837918
Osteopenia 11.39 11.28 206 449336 17935 55824590
Skin papilloma 11.38 11.28 68 449474 4421 55838104
Systemic candida 11.38 11.28 5 449537 3036 55839489
Weight increased 11.38 11.28 2042 447500 227661 55614864
Culture tissue specimen positive 11.36 11.28 4 449538 7 55842518
Spinal cord infection 11.35 11.28 19 449523 608 55841917
Endocarditis 11.34 11.28 16 449526 5400 55837125
Catatonia 11.34 11.28 9 449533 3955 55838570
Renal tubular disorder 11.32 11.28 3 449539 2503 55840022
Intervertebral disc space narrowing 11.31 11.28 24 449518 921 55841604
Chronic sinusitis 11.31 11.28 32 449510 8346 55834179
Disseminated strongyloidiasis 11.30 11.28 5 449537 20 55842505

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 3843.12 13.24 4190 64539 343084 31285531
Rheumatoid arthritis 2688.18 13.24 1523 67206 46286 31582329
Drug ineffective 2027.90 13.24 3285 65444 392288 31236327
Drug intolerance 1311.51 13.24 1005 67724 51028 31577587
Joint swelling 1227.40 13.24 977 67752 52454 31576161
Synovitis 1053.68 13.24 520 68209 11763 31616852
Contraindicated product administered 870.15 13.24 539 68190 19233 31609382
Treatment failure 747.24 13.24 655 68074 40137 31588478
C-reactive protein abnormal 507.53 13.24 274 68455 7495 31621120
Therapeutic product effect decreased 498.68 13.24 467 68262 31155 31597460
Apparent death 489.19 13.24 210 68519 3395 31625220
Arthropathy 443.65 13.24 388 68341 23663 31604952
Bone erosion 402.58 13.24 180 68549 3223 31625392
Electrocardiogram QT prolonged 392.38 13.24 447 68282 37540 31591075
Arthralgia 372.42 13.24 933 67796 150491 31478124
Pain 341.27 13.24 1032 67697 185727 31442888
Musculoskeletal stiffness 341.17 13.24 434 68295 40891 31587724
Red blood cell sedimentation rate abnormal 335.75 13.24 153 68576 2869 31625746
Death 317.17 13.24 196 68533 360373 31268242
Diverticulitis 312.46 13.24 285 68444 18360 31610255
Red blood cell sedimentation rate increased 294.06 13.24 198 68531 8148 31620467
Loss of personal independence in daily activities 268.79 13.24 319 68410 27969 31600646
Hand deformity 252.18 13.24 126 68603 2921 31625694
C-reactive protein increased 250.05 13.24 408 68321 48242 31580373
Mobility decreased 249.89 13.24 303 68426 27166 31601449
Febrile neutropenia 221.93 13.24 10 68719 121839 31506776
Drug hypersensitivity 207.75 13.24 475 68254 72124 31556491
Impaired work ability 198.86 13.24 136 68593 5741 31622874
Long QT syndrome 196.67 13.24 98 68631 2258 31626357
Sleep disorder due to general medical condition, insomnia type 191.06 13.24 80 68649 1211 31627404
Condition aggravated 185.64 13.24 775 67954 163234 31465381
Peripheral swelling 183.16 13.24 434 68295 67431 31561184
Therapeutic product effect incomplete 176.96 13.24 330 68399 43366 31585249
Rheumatoid factor negative 174.94 13.24 67 68662 792 31627823
Rheumatoid factor positive 173.81 13.24 63 68666 631 31627984
Anaemia 169.95 13.24 129 68600 213393 31415222
Intentional product use issue 160.48 13.24 340 68389 49007 31579608
Lymphoma 159.76 13.24 155 68574 10788 31617827
Drug ineffective for unapproved indication 151.69 13.24 190 68539 17600 31611015
Constipation 151.12 13.24 41 68688 123950 31504665
Drug effective for unapproved indication 147.23 13.24 75 68654 1813 31626802
Knee arthroplasty 145.99 13.24 118 68611 6440 31622175
Hepatitis 145.70 13.24 208 68521 21858 31606757
Pulmonary thrombosis 145.11 13.24 120 68609 6765 31621850
Systemic lupus erythematosus 141.85 13.24 86 68643 2942 31625673
Polyarthritis 138.20 13.24 96 68633 4156 31624459
Limb discomfort 136.33 13.24 138 68591 10111 31618504
Gastrointestinal disorder 136.09 13.24 241 68488 30419 31598196
Dehydration 134.97 13.24 45 68684 119066 31509549
COVID-19 132.35 13.24 336 68393 54485 31574130
Arthritis 131.66 13.24 223 68506 27162 31601453
Drug tolerance decreased 130.73 13.24 68 68661 1719 31626896
Terminal state 128.49 13.24 87 68642 3611 31625004
Onychoclasis 127.59 13.24 67 68662 1728 31626887
Malignant neoplasm progression 127.57 13.24 12 68717 78986 31549629
Anti-cyclic citrullinated peptide antibody positive 124.27 13.24 61 68668 1359 31627256
Hypotension 122.10 13.24 159 68570 204459 31424156
Toxicity to various agents 121.15 13.24 129 68600 181358 31447257
Rheumatoid nodule 120.10 13.24 74 68655 2607 31626008
Herpes zoster 120.08 13.24 234 68495 31759 31596856
Vomiting 117.97 13.24 190 68539 223783 31404832
Osteoarthritis 117.54 13.24 174 68555 18893 31609722
Joint stiffness 117.27 13.24 126 68603 9895 31618720
Pyrexia 116.77 13.24 309 68420 303531 31325084
Decreased appetite 116.21 13.24 97 68632 153120 31475495
Product use in unapproved indication 115.39 13.24 473 68256 98698 31529917
Bone cyst 114.09 13.24 54 68675 1107 31627508
Acute kidney injury 111.65 13.24 279 68450 279435 31349180
Seizure 110.74 13.24 39 68690 99729 31528886
Abdominal pain 109.94 13.24 93 68636 145859 31482756
Diarrhoea 103.60 13.24 404 68325 352005 31276610
Joint lock 101.53 13.24 50 68679 1122 31627493
Acne cystic 101.07 13.24 39 68690 471 31628144
Drug specific antibody present 98.58 13.24 67 68662 2798 31625817
Confusional state 95.54 13.24 89 68640 133245 31495370
Tooth loss 93.91 13.24 72 68657 3636 31624979
Nodule 93.36 13.24 86 68643 5604 31623011
Psoriatic arthropathy 93.03 13.24 160 68569 19723 31608892
Plasma cell myeloma 92.84 13.24 8 68721 56523 31572092
Overdose 92.41 13.24 34 68695 84630 31543985
Photosensitivity reaction 86.37 13.24 107 68622 9797 31618818
Completed suicide 85.36 13.24 46 68683 91468 31537147
Syncope 82.14 13.24 41 68688 85141 31543474
Physical disability 81.38 13.24 45 68684 1290 31627325
Drug abuse 80.56 13.24 45 68684 87713 31540902
Mass 80.25 13.24 89 68640 7242 31621373
Hip arthroplasty 79.63 13.24 68 68661 4007 31624608
Disability 79.51 13.24 72 68657 4589 31624026
X-ray abnormal 78.80 13.24 32 68697 446 31628169
Joint arthroplasty 77.88 13.24 37 68692 765 31627850
Pain in extremity 75.33 13.24 470 68259 115733 31512882
Blood glucose increased 72.86 13.24 21 68708 61062 31567553
Pulmonary fibrosis 72.66 13.24 130 68599 16530 31612085
Intestinal polyp 71.53 13.24 37 68692 924 31627691
Rhabdomyolysis 70.27 13.24 25 68704 63556 31565059
Cytology abnormal 70.16 13.24 28 68701 372 31628243
Intestinal sepsis 69.92 13.24 31 68698 543 31628072
Ill-defined disorder 69.34 13.24 109 68620 12468 31616147
Loss of consciousness 69.09 13.24 41 68688 77314 31551301
Hyperkalaemia 68.28 13.24 27 68702 64324 31564291
Dyspnoea 68.18 13.24 451 68278 343028 31285587
Platelet count decreased 67.64 13.24 84 68645 110351 31518264
COVID-19 pneumonia 67.46 13.24 108 68621 12547 31616068
Fall 67.02 13.24 195 68534 185894 31442721
Inflammation 66.45 13.24 160 68569 25081 31603534
Grip strength decreased 66.18 13.24 51 68678 2595 31626020
Thrombocytopenia 65.26 13.24 132 68597 142615 31486000
Drug use disorder 64.96 13.24 60 68669 3923 31624692
Foot deformity 64.77 13.24 61 68668 4088 31624527
Skin ulcer 64.09 13.24 137 68592 19848 31608767
Gait inability 63.44 13.24 133 68596 19011 31609604
Neoplasm malignant 63.29 13.24 132 68597 18799 31609816
Blood pressure diastolic abnormal 63.08 13.24 59 68670 3920 31624695
Neutropenia 61.46 13.24 133 68596 140231 31488384
Drug dependence 60.38 13.24 144 68585 22435 31606180
Urinary tract infection 60.28 13.24 47 68682 76822 31551793
Bladder transitional cell carcinoma 59.19 13.24 47 68682 2499 31626116
Hypertransaminasaemia 59.15 13.24 59 68670 4245 31624370
Victim of child abuse 59.07 13.24 32 68697 880 31627735
COVID-19 treatment 58.69 13.24 22 68707 244 31628371
Alopecia 58.63 13.24 135 68594 20560 31608055
Arthritis bacterial 57.76 13.24 60 68669 4530 31624085
Alanine aminotransferase abnormal 57.53 13.24 56 68673 3911 31624704
Joint ankylosis 56.65 13.24 33 68696 1047 31627568
Somnolence 55.45 13.24 81 68648 99364 31529251
Coronavirus infection 55.31 13.24 53 68676 3630 31624985
Hallucination 55.26 13.24 16 68713 46394 31582221
Blood pressure systolic abnormal 55.25 13.24 49 68680 3038 31625577
Coma 55.24 13.24 11 68718 41139 31587476
General physical health deterioration 55.22 13.24 101 68628 113334 31515281
Ascites 54.98 13.24 11 68718 41002 31587613
Dizziness 54.73 13.24 234 68495 198913 31429702
No adverse event 53.38 13.24 126 68603 19499 31609116
Blood creatinine increased 53.23 13.24 69 68660 89009 31539606
Swelling 53.07 13.24 190 68539 37168 31591447
Cardiac failure 53.01 13.24 65 68664 85888 31542727
Hospitalisation 52.66 13.24 21 68708 49786 31578829
Neutrophil count decreased 51.67 13.24 18 68711 46376 31582239
Epistaxis 51.53 13.24 26 68703 53681 31574934
Musculoskeletal pain 51.50 13.24 162 68567 29666 31598949
Renal impairment 51.48 13.24 67 68662 86282 31542333
Gastric disorder 50.33 13.24 90 68639 11438 31617177
Premature baby 50.24 13.24 117 68612 17949 31610666
Gastrointestinal haemorrhage 49.27 13.24 64 68665 82485 31546130
Soft tissue swelling 47.67 13.24 21 68708 362 31628253
Therapeutic response decreased 46.71 13.24 145 68584 26364 31602251
Seronegative arthritis 46.43 13.24 28 68701 948 31627667
Deep vein thrombosis 44.65 13.24 254 68475 60482 31568133
Cardiac arrest 44.50 13.24 78 68651 88984 31539631
Foetal exposure during pregnancy 44.36 13.24 191 68538 40685 31587930
Skin laceration 43.55 13.24 84 68645 11307 31617308
Liver function test increased 42.90 13.24 89 68640 12625 31615990
Joint range of motion decreased 42.79 13.24 62 68667 6599 31622016
Lupus nephritis 42.65 13.24 18 68711 278 31628337
Prerenal failure 42.64 13.24 34 68695 1819 31626796
Blood pressure decreased 42.21 13.24 26 68703 48065 31580550
Abdominal discomfort 42.16 13.24 222 68507 51345 31577270
Disease progression 41.86 13.24 83 68646 90381 31538234
Anxiety 41.72 13.24 84 68645 90949 31537666
Infection 41.50 13.24 312 68417 81619 31546996
Malaise 40.94 13.24 207 68522 168304 31460311
Orthostatic hypotension 40.74 13.24 3 68726 24116 31604499
Pancytopenia 40.50 13.24 80 68649 87236 31541379
Pneumonia aspiration 39.85 13.24 17 68712 38709 31589906
Skin mass 39.77 13.24 44 68685 3570 31625045
Disorientation 39.66 13.24 9 68720 30735 31597880
Hepatic function abnormal 39.47 13.24 20 68709 41202 31587413
Immobile 39.36 13.24 36 68693 2324 31626291
Localised infection 39.35 13.24 96 68633 15169 31613446
Oral surgery 39.35 13.24 21 68708 560 31628055
Restlessness 39.19 13.24 3 68726 23358 31605257
Type 2 lepra reaction 39.08 13.24 18 68711 346 31628269
Dysphagia 38.39 13.24 41 68688 57635 31570980
Agitation 37.76 13.24 37 68692 54132 31574483
Hyponatraemia 37.44 13.24 64 68665 73735 31554880
Disturbance in attention 37.33 13.24 3 68726 22447 31606168
Asthenia 37.33 13.24 310 68419 224445 31404170
Liver injury 37.10 13.24 87 68642 13405 31615210
Intentional overdose 36.85 13.24 22 68707 41367 31587248
Haematuria 36.70 13.24 28 68701 46286 31582329
Unresponsive to stimuli 36.57 13.24 6 68723 25794 31602821
Blood urea increased 36.43 13.24 9 68720 29003 31599612
International normalised ratio increased 36.27 13.24 27 68702 45196 31583419
Pneumonia 35.85 13.24 512 68217 334800 31293815
Aggression 35.85 13.24 18 68711 37273 31591342
Hepatic enzyme increased 35.35 13.24 163 68566 35745 31592870
Medical device implantation 35.34 13.24 20 68709 600 31628015
Blood pressure fluctuation 35.20 13.24 119 68610 22617 31605998
Limb deformity 35.15 13.24 19 68710 520 31628095
Low birth weight baby 35.13 13.24 58 68671 6912 31621703
Abdominal distension 34.89 13.24 35 68694 50649 31577966
C-reactive protein decreased 34.88 13.24 30 68699 1785 31626830
Basal cell carcinoma 34.42 13.24 102 68627 18077 31610538
Joint effusion 34.31 13.24 46 68683 4553 31624062
Dyskinesia 34.21 13.24 3 68726 20907 31607708
Osteolysis 34.17 13.24 33 68696 2282 31626333
Lethargy 33.76 13.24 21 68708 38620 31589995
Dysarthria 33.03 13.24 14 68715 32003 31596612
Neoplasm progression 32.91 13.24 3 68726 20269 31608346
Red blood cell sedimentation rate 32.75 13.24 23 68706 1013 31627602
Bone marrow failure 32.71 13.24 10 68719 27998 31600617
Product use issue 32.70 13.24 223 68506 56536 31572079
Metabolic acidosis 32.56 13.24 23 68706 39554 31589061
Fatigue 32.34 13.24 522 68207 334684 31293931
Haematemesis 32.13 13.24 8 68721 25645 31602970
Lymphoedema 32.08 13.24 39 68690 3501 31625114
Cutaneous lupus erythematosus 31.72 13.24 20 68709 734 31627881
Hepatic cirrhosis 31.66 13.24 90 68639 15584 31613031
White blood cell count increased 31.65 13.24 23 68706 38977 31589638
Atrial fibrillation 31.63 13.24 133 68596 113650 31514965
Heart block congenital 31.62 13.24 9 68720 37 31628578
Panniculitis 31.13 13.24 28 68701 1768 31626847
Hepatic enzyme abnormal 31.02 13.24 32 68697 2396 31626219
Irritability 30.97 13.24 6 68723 22883 31605732
Granuloma skin 30.94 13.24 23 68706 1108 31627507
Blood bilirubin increased 30.82 13.24 19 68710 35117 31593498
Herpes simplex viraemia 30.60 13.24 10 68719 71 31628544
Fine motor skill dysfunction 30.59 13.24 27 68702 1663 31626952
Cerebrovascular accident 30.25 13.24 81 68648 79403 31549212
Blood pressure systolic increased 30.22 13.24 102 68627 19368 31609247
Flushing 29.78 13.24 14 68715 30114 31598501
Pulmonary embolism 29.76 13.24 289 68440 81357 31547258
Muscle spasms 29.64 13.24 65 68664 68253 31560362
Respiratory arrest 29.56 13.24 10 68719 26247 31602368
Hyperglycaemia 28.96 13.24 22 68707 36454 31592161
Suicidal ideation 28.85 13.24 22 68707 36384 31592231
Epidural lipomatosis 28.57 13.24 19 68710 765 31627850
Cerebral haemorrhage 28.43 13.24 18 68711 32794 31595821
Blood parathyroid hormone decreased 27.77 13.24 23 68706 1299 31627316
Chest pain 27.63 13.24 145 68584 116812 31511803
Hypokalaemia 27.59 13.24 46 68683 53528 31575087
Shoulder operation 27.56 13.24 20 68709 928 31627687
Acute lung injury 27.39 13.24 23 68706 1324 31627291
Dactylitis 27.32 13.24 19 68710 824 31627791
Sensitivity to weather change 27.21 13.24 24 68705 1477 31627138
Cognitive disorder 27.18 13.24 10 68719 24913 31603702
Musculoskeletal discomfort 27.10 13.24 52 68677 6971 31621644
Cardio-respiratory arrest 27.02 13.24 44 68685 51682 31576933
Colitis ulcerative 26.96 13.24 4 68725 18525 31610090
Wheezing 26.95 13.24 23 68706 35963 31592652
Medication error 26.83 13.24 8 68721 22764 31605851
Tenosynovitis 26.77 13.24 39 68690 4171 31624444
Incorrect dose administered 26.60 13.24 23 68706 35729 31592886
Suicide attempt 26.47 13.24 25 68704 37223 31591392
Depressed level of consciousness 26.17 13.24 27 68702 38574 31590041
Maculopathy 25.99 13.24 19 68710 892 31627723
External auditory canal atresia 25.88 13.24 11 68718 173 31628442
Oral disorder 25.88 13.24 37 68692 3890 31624725
Hypophagia 25.51 13.24 8 68721 22034 31606581
Urticaria 25.25 13.24 212 68517 57305 31571310
Coronary artery disease 25.22 13.24 38 68691 46049 31582566
Cryopyrin associated periodic syndrome 25.20 13.24 9 68720 86 31628529
Cytomegalovirus infection 25.17 13.24 11 68718 24696 31603919
Septic shock 24.73 13.24 68 68661 66090 31562525
Intestinal obstruction 24.72 13.24 7 68722 20603 31608012
Interstitial lung disease 24.70 13.24 222 68507 61181 31567434
Product quality issue 24.58 13.24 3 68726 16108 31612507
Vision blurred 24.48 13.24 33 68696 41882 31586733
Neck mass 24.42 13.24 23 68706 1541 31627074
Cardiogenic shock 24.42 13.24 9 68720 22399 31606216
Tuberculosis 24.27 13.24 55 68674 8286 31620329
Juvenile idiopathic arthritis 24.26 13.24 24 68705 1709 31626906
Hypoglycaemia 24.20 13.24 46 68683 50900 31577715
Osteonecrosis of jaw 24.12 13.24 4 68725 17067 31611548
Subdural haematoma 23.59 13.24 6 68723 18965 31609650
Microcephaly 23.54 13.24 17 68712 783 31627832
Thrombosis 23.44 13.24 173 68556 44978 31583637
Palmar-plantar erythrodysaesthesia syndrome 23.33 13.24 3 68726 15480 31613135
Maternal exposure before pregnancy 23.18 13.24 16 68713 685 31627930
Acute myocardial infarction 23.18 13.24 47 68682 50776 31577839
Medium-chain acyl-coenzyme A dehydrogenase deficiency 23.17 13.24 7 68722 37 31628578
Haemorrhage 23.13 13.24 42 68687 47292 31581323
Full blood count decreased 23.10 13.24 4 68725 16536 31612079
Blood potassium increased 23.06 13.24 3 68726 15342 31613273
Latent tuberculosis 23.05 13.24 20 68709 1204 31627411
Nodular regenerative hyperplasia 23.05 13.24 18 68711 934 31627681
Fragile X syndrome 23.01 13.24 7 68722 38 31628577
Vitamin D deficiency 22.98 13.24 44 68685 5888 31622727
Diffuse idiopathic skeletal hyperostosis 22.86 13.24 7 68722 39 31628576
Stevens-Johnson syndrome 22.58 13.24 5 68724 17367 31611248
Urinary retention 22.40 13.24 24 68705 33701 31594914
Mental status changes 22.37 13.24 27 68702 35941 31592674
Aspartate aminotransferase increased 22.31 13.24 66 68663 62653 31565962
Iris coloboma 22.30 13.24 6 68723 19 31628596
Encephalitis Japanese B 22.30 13.24 6 68723 19 31628596
Erectile dysfunction 22.22 13.24 7 68722 19228 31609387
Glucose-6-phosphate dehydrogenase deficiency 22.19 13.24 9 68720 125 31628490
Abnormal behaviour 22.16 13.24 12 68717 23816 31604799
Food intolerance 22.14 13.24 20 68709 1270 31627345
Retinal toxicity 22.13 13.24 13 68716 419 31628196
Hypofibrinogenaemia 22.07 13.24 22 68707 1581 31627034
Retinal coloboma 22.06 13.24 6 68723 20 31628595
Jaundice 21.91 13.24 20 68709 30267 31598348
Arthrodesis 21.38 13.24 13 68716 447 31628168
Drug withdrawal syndrome 21.35 13.24 7 68722 18743 31609872
Maternal exposure during pregnancy 21.16 13.24 37 68692 4619 31623996
Child abuse 21.12 13.24 12 68717 363 31628252
Myalgia 21.03 13.24 91 68638 77167 31551448
Pulmonary toxicity 20.98 13.24 40 68689 5337 31623278
Blood creatine phosphokinase increased 20.73 13.24 37 68692 41937 31586678
Ocular toxicity 20.65 13.24 10 68719 216 31628399
External ear disorder 20.65 13.24 6 68723 27 31628588
Cellulitis 20.57 13.24 46 68683 47972 31580643
Hypocalcaemia 20.54 13.24 11 68718 21967 31606648
Trisomy 8 20.37 13.24 7 68722 59 31628556
Meningitis noninfective 20.21 13.24 5 68724 10 31628605
Disease recurrence 20.08 13.24 87 68642 18574 31610041
PaO2/FiO2 ratio decreased 19.97 13.24 6 68723 31 31628584
Ventricular fibrillation 19.83 13.24 8 68721 18840 31609775
Ossicle disorder 19.81 13.24 6 68723 32 31628583
Angina pectoris 19.79 13.24 21 68708 29620 31598995
Melaena 19.79 13.24 25 68704 32629 31595986
Lymphocyte count decreased 19.79 13.24 10 68719 20639 31607976
Anaphylactic reaction 19.67 13.24 21 68708 29532 31599083
Gamma-glutamyltransferase increased 19.39 13.24 19 68710 27806 31600809
C-reactive protein 19.35 13.24 8 68721 117 31628498
Bradycardia 19.27 13.24 81 68648 69246 31559369
Angioedema 19.09 13.24 27 68702 33591 31595024
Mycobacterium fortuitum infection 18.90 13.24 9 68720 187 31628428
Peritonitis 18.77 13.24 5 68724 15322 31613293
Gout 18.66 13.24 8 68721 18166 31610449
Acute cutaneous lupus erythematosus 18.56 13.24 7 68722 79 31628536
Tooth injury 18.33 13.24 17 68712 1117 31627498
Ataxia 18.21 13.24 3 68726 12860 31615755
Dyspepsia 18.21 13.24 127 68602 32426 31596189
Pancreatitis 18.15 13.24 31 68698 35740 31592875
Stent placement 18.11 13.24 35 68694 4716 31623899
Enthesopathy 18.11 13.24 33 68696 4254 31624361
Depression 18.02 13.24 119 68610 90696 31537919
Pulmonary oedema 17.96 13.24 44 68685 44458 31584157
Metastases to liver 17.94 13.24 3 68726 12724 31615891
Andersen-Tawil syndrome 17.78 13.24 4 68725 4 31628611
Neonatal lupus erythematosus 17.78 13.24 4 68725 4 31628611
Infection reactivation 17.65 13.24 18 68711 1330 31627285
Antinuclear antibody positive 17.59 13.24 18 68711 1335 31627280
Wrist surgery 17.50 13.24 8 68721 151 31628464
Therapeutic response unexpected 17.43 13.24 51 68678 8973 31619642
Liver function test 17.42 13.24 6 68723 51 31628564
Chronic kidney disease 17.41 13.24 35 68694 37940 31590675
Therapy non-responder 17.23 13.24 129 68600 33682 31594933
Oedema peripheral 17.07 13.24 154 68575 109685 31518930
Device related infection 17.01 13.24 7 68722 16292 31612323
Visual acuity reduced 17.00 13.24 6 68723 15337 31613278
Unevaluable event 16.93 13.24 25 68704 30550 31598065
Hepatic failure 16.90 13.24 28 68701 32674 31595941
Neutrophil Pelger-Huet anomaly present 16.90 13.24 9 68720 239 31628376
Product dose omission issue 16.86 13.24 147 68582 105439 31523176
Disseminated intravascular coagulation 16.80 13.24 12 68717 20525 31608090
Oral pustule 16.80 13.24 9 68720 242 31628373
Antiphospholipid syndrome 16.74 13.24 11 68718 434 31628181
Lupus pneumonitis 16.65 13.24 6 68723 59 31628556
Therapy partial responder 16.63 13.24 41 68688 6521 31622094
Encephalopathy 16.61 13.24 28 68701 32446 31596169
Squamous cell carcinoma 16.52 13.24 56 68673 10655 31617960
Thrombocytosis 16.16 13.24 29 68700 3694 31624921
Nervousness 16.16 13.24 3 68726 11797 31616818
Hallucination, visual 16.14 13.24 7 68722 15787 31612828
Cyanosis 16.04 13.24 3 68726 11732 31616883
Viral load abnormal 15.97 13.24 6 68723 67 31628548
Ulcer 15.88 13.24 45 68684 7776 31620839
Pneumocystis jirovecii pneumonia 15.82 13.24 10 68719 18241 31610374
Presyncope 15.72 13.24 9 68720 17319 31611296
Urinary incontinence 15.70 13.24 9 68720 17311 31611304
Lupus-like syndrome 15.70 13.24 23 68706 2472 31626143
Stress ulcer 15.66 13.24 6 68723 71 31628544
Cerebral infarction 15.63 13.24 20 68709 25957 31602658
Viral vasculitis 15.58 13.24 6 68723 72 31628543
Malnutrition 15.57 13.24 3 68726 11490 31617125
Heart rate increased 15.55 13.24 42 68687 41068 31587547
Full blood count abnormal 15.54 13.24 8 68721 16339 31612276
Scleroderma renal crisis 15.47 13.24 7 68722 129 31628486
Bursa removal 15.42 13.24 7 68722 130 31628485
Agranulocytosis 15.40 13.24 14 68715 21233 31607382
Cytokine storm 15.38 13.24 12 68717 622 31627993
Anomalous pulmonary venous connection 15.36 13.24 6 68723 75 31628540
Dysuria 15.36 13.24 18 68711 24276 31604339
Rheumatoid lung 15.35 13.24 13 68716 757 31627858
Haematocrit decreased 15.30 13.24 26 68703 30035 31598580
Dysgeusia 15.25 13.24 17 68712 23449 31605166
Acute myeloid leukaemia 15.16 13.24 11 68718 18661 31609954
Methaemoglobinaemia 15.13 13.24 25 68704 2981 31625634
Q fever 15.13 13.24 7 68722 136 31628479
Joint warmth 14.97 13.24 9 68720 303 31628312
Pneumatosis intestinalis 14.96 13.24 28 68701 3683 31624932
Haemorrhage intracranial 14.93 13.24 7 68722 15081 31613534
Tubulointerstitial nephritis 14.88 13.24 11 68718 18485 31610130
Electrolyte imbalance 14.81 13.24 4 68725 12144 31616471
Red blood cell count decreased 14.76 13.24 22 68707 26785 31601830
Status epilepticus 14.73 13.24 4 68725 12102 31616513
Diabetes mellitus 14.70 13.24 149 68580 42407 31586208
Tuberculin test positive 14.69 13.24 15 68714 1110 31627505
Psychotic disorder 14.66 13.24 16 68713 22277 31606338
Accidental overdose 14.65 13.24 11 68718 18339 31610276
Myocardial ischaemia 14.63 13.24 9 68720 16658 31611957
Neutrophil count increased 14.51 13.24 8 68721 15723 31612892
Ankle deformity 14.48 13.24 8 68721 229 31628386
Optic nerve operation 14.45 13.24 10 68719 430 31628185
Retro-orbital neoplasm 14.34 13.24 4 68725 15 31628600
Speech sound disorder 14.34 13.24 7 68722 154 31628461
Upper respiratory tract infection 14.29 13.24 111 68618 29311 31599304
Faeces discoloured 14.26 13.24 6 68723 13780 31614835
Blood potassium decreased 14.24 13.24 9 68720 16417 31612198
Gastric ulcer 14.16 13.24 7 68722 14627 31613988
Therapeutic product effect delayed 14.09 13.24 15 68714 1165 31627450
Empyema 14.07 13.24 24 68705 2937 31625678
Blood lactate dehydrogenase increased 14.04 13.24 14 68715 20325 31608290
Perineal infection 13.96 13.24 11 68718 578 31628037
Face oedema 13.91 13.24 3 68726 10613 31618002
Blood sodium decreased 13.83 13.24 8 68721 15307 31613308
Scrotal infection 13.78 13.24 11 68718 589 31628026
Trigger finger 13.76 13.24 12 68717 727 31627888
Pulmonary haemosiderosis 13.76 13.24 4 68725 18 31628597
Dyspnoea exertional 13.71 13.24 41 68688 38796 31589819
Product administration error 13.71 13.24 8 68721 15239 31613376
Haemoptysis 13.65 13.24 31 68698 32158 31596457
Blood alkaline phosphatase increased 13.63 13.24 27 68702 29426 31599189
Sepsis 13.47 13.24 240 68489 151689 31476926
Aortic bruit 13.45 13.24 7 68722 177 31628438
Vasculitis 13.45 13.24 45 68684 8505 31620110
Generalised tonic-clonic seizure 13.44 13.24 14 68715 19917 31608698
Neutropenic sepsis 13.44 13.24 5 68724 12374 31616241
Blood pressure diastolic increased 13.36 13.24 29 68700 4244 31624371
Neurological examination abnormal 13.32 13.24 8 68721 269 31628346
Olfactory nerve disorder 13.26 13.24 4 68725 21 31628594

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 7805.40 11.09 8721 376328 283084 70260311
Drug ineffective 6328.58 11.09 14927 370122 924825 69618570
Drug intolerance 5311.22 11.09 6322 378727 219365 70324030
Joint swelling 3880.97 11.09 5752 379297 247459 70295936
Synovitis 3773.66 11.09 4054 380995 125174 70418221
Contraindicated product administered 3327.93 11.09 3872 381177 130740 70412655
Treatment failure 3002.54 11.09 3802 381247 140340 70403055
Off label use 2894.16 11.09 9708 375341 733352 69810043
Therapeutic product effect decreased 2312.36 11.09 3336 381713 139682 70403713
Arthropathy 2219.85 11.09 3357 381692 146700 70396695
Systemic lupus erythematosus 1709.20 11.09 2420 382629 99482 70443913
Arthralgia 1617.88 11.09 6188 378861 497202 70046193
Hand deformity 1398.77 11.09 2019 383030 84463 70458932
Death 1394.34 11.09 515 384534 509546 70033849
C-reactive protein abnormal 1382.39 11.09 1353 383696 37226 70506169
Pain 1329.57 11.09 6821 378228 621995 69921400
Musculoskeletal stiffness 1221.65 11.09 2564 382485 145196 70398199
Swelling 1155.69 11.09 2907 382142 185632 70357763
Pemphigus 1152.32 11.09 1805 383244 81231 70462164
Rheumatoid factor positive 1151.76 11.09 1367 383682 47033 70496362
Abdominal discomfort 1134.91 11.09 3132 381917 211526 70331869
Anti-cyclic citrullinated peptide antibody positive 1126.62 11.09 1633 383416 68552 70474843
Red blood cell sedimentation rate abnormal 1123.82 11.09 892 384157 18411 70524984
Acute kidney injury 1085.56 11.09 615 384434 474009 70069386
Peripheral swelling 1035.50 11.09 3227 381822 233336 70310059
Alopecia 990.98 11.09 2837 382212 195653 70347742
Glossodynia 980.87 11.09 1717 383332 84770 70458625
Hepatic enzyme increased 926.72 11.09 2387 382662 154603 70388792
Drug hypersensitivity 896.80 11.09 3295 381754 259164 70284231
Red blood cell sedimentation rate increased 818.07 11.09 1029 384020 37613 70505782
Pericarditis 804.61 11.09 1558 383491 83147 70460248
Anaemia 794.66 11.09 617 384432 402806 70140589
Completed suicide 794.39 11.09 138 384911 226997 70316398
Febrile neutropenia 779.60 11.09 96 384953 204222 70339173
Therapeutic product effect incomplete 771.37 11.09 1884 383165 117998 70425397
Condition aggravated 738.54 11.09 4397 380652 423238 70120157
Loss of personal independence in daily activities 709.90 11.09 1481 383568 83429 70459966
Hypersensitivity 686.87 11.09 2766 382283 227046 70316349
C-reactive protein increased 662.74 11.09 1691 383358 108826 70434569
Wound 649.31 11.09 1565 383484 97167 70446228
Hypotension 643.58 11.09 749 384300 403632 70139763
Gastrointestinal disorder 630.99 11.09 1612 383437 103815 70439580
Constipation 598.15 11.09 312 384737 252126 70291269
Dehydration 593.93 11.09 242 384807 225900 70317495
Helicobacter infection 572.07 11.09 1059 383990 54597 70488798
Discomfort 560.77 11.09 1543 383506 103893 70439502
Toxicity to various agents 550.70 11.09 763 384286 381409 70161986
Malignant neoplasm progression 544.89 11.09 28 385021 121711 70421684
Infusion related reaction 533.95 11.09 2306 382743 195228 70348167
Duodenal ulcer perforation 529.66 11.09 976 384073 50136 70493259
Drug abuse 526.82 11.09 84 384965 147172 70396223
Arthritis 509.27 11.09 1422 383627 96558 70446837
Infection 509.20 11.09 2380 382669 208405 70334990
Bone erosion 498.79 11.09 508 384541 14665 70528730
Sleep disorder due to general medical condition, insomnia type 487.35 11.09 771 384278 34961 70508434
Maternal exposure during pregnancy 483.09 11.09 1551 383498 113794 70429601
Seizure 477.76 11.09 184 384865 177778 70365617
Rash 465.24 11.09 4518 380531 506044 70037351
Muscle injury 460.69 11.09 783 384266 37711 70505684
Hyponatraemia 459.75 11.09 148 384901 159939 70383456
Neutropenia 446.88 11.09 442 384607 256714 70286681
Irritable bowel syndrome 444.93 11.09 904 384145 49946 70493449
Inflammation 437.98 11.09 1171 383878 77494 70465901
Folliculitis 432.41 11.09 806 384243 41764 70501631
Retinal toxicity 422.09 11.09 186 384863 1170 70542225
Osteoarthritis 415.06 11.09 1106 383943 73041 70470354
Product use issue 410.66 11.09 1999 383050 177938 70365457
Thrombocytopenia 407.41 11.09 418 384631 238692 70304703
Mobility decreased 401.68 11.09 1352 383697 101647 70441748
Psoriatic arthropathy 395.28 11.09 998 384051 63773 70479622
Ill-defined disorder 394.92 11.09 900 384149 53841 70489554
Impaired healing 393.90 11.09 1087 383962 73287 70470108
Lower respiratory tract infection 382.12 11.09 1406 383643 110507 70432888
Somnolence 378.66 11.09 367 384682 215239 70328156
Sinusitis 376.30 11.09 1866 383183 167329 70376066
Hyperkalaemia 369.70 11.09 66 384983 106525 70436870
Tremor 367.43 11.09 193 384856 155431 70387964
Atrial fibrillation 362.26 11.09 282 384767 184066 70359329
Rheumatoid nodule 354.01 11.09 423 384626 14644 70528751
Gastrointestinal haemorrhage 351.02 11.09 153 384896 137255 70406140
Dyspnoea 344.66 11.09 2609 382440 767451 69775944
Platelet count decreased 338.47 11.09 282 384767 177940 70365455
Rhabdomyolysis 337.13 11.09 57 384992 95703 70447692
Overdose 336.90 11.09 257 384792 169488 70373907
Fibromyalgia 333.09 11.09 776 384273 47098 70496297
Bradycardia 325.92 11.09 134 384915 124481 70418914
Knee arthroplasty 314.63 11.09 622 384427 33679 70509716
Impaired work ability 312.63 11.09 414 384635 15926 70527469
Sepsis 299.93 11.09 543 384506 244002 70299393
Cardio-respiratory arrest 292.67 11.09 91 384958 100586 70442809
Plasma cell myeloma 290.05 11.09 30 385019 73171 70470224
Blister 289.47 11.09 1197 383852 99329 70444066
Musculoskeletal disorder 289.12 11.09 443 384606 19528 70523867
Cardiac arrest 288.85 11.09 265 384784 159569 70383826
Depressed level of consciousness 288.71 11.09 61 384988 87370 70456025
Coma 287.50 11.09 72 384977 91772 70451623
Renal failure 282.53 11.09 367 384682 188703 70354692
Neutrophil count decreased 280.66 11.09 56 384993 83500 70459895
Joint range of motion decreased 277.16 11.09 503 384546 25523 70517872
Lactic acidosis 275.73 11.09 20 385029 65004 70478391
Disability 271.96 11.09 370 384679 14613 70528782
Syncope 267.32 11.09 303 384746 165406 70377989
Nasopharyngitis 263.80 11.09 2086 382963 220120 70323275
Grip strength decreased 260.29 11.09 371 384678 15314 70528081
Drug tolerance decreased 257.65 11.09 292 384757 9541 70533854
Agitation 254.73 11.09 94 384955 93281 70450114
Cardiac failure 254.63 11.09 242 384807 143299 70400096
Hip arthroplasty 254.19 11.09 506 384543 27534 70515861
Musculoskeletal pain 254.13 11.09 1068 383981 89259 70454136
Pneumonia 250.01 11.09 2055 382994 594177 69949218
Disease progression 249.98 11.09 289 384760 156383 70387012
Decreased appetite 248.73 11.09 836 384213 303944 70239451
Drug interaction 247.25 11.09 1147 383902 380294 70163101
Intentional product use issue 246.67 11.09 1296 383753 118846 70424549
Tachycardia 242.81 11.09 302 384747 158244 70385151
Fall 239.44 11.09 1422 383627 442674 70100721
Joint stiffness 235.78 11.09 562 384487 34614 70508781
Metabolic acidosis 235.19 11.09 57 384992 74289 70469106
Hallucination 234.43 11.09 62 384987 76198 70467197
Cerebrovascular accident 233.95 11.09 260 384789 143210 70400185
Anxiety 232.04 11.09 534 384515 219796 70323599
Pulmonary fibrosis 229.80 11.09 548 384501 33762 70509633
White blood cell count decreased 229.61 11.09 355 384694 169786 70373609
Epistaxis 229.58 11.09 136 384913 102491 70440904
Blood parathyroid hormone decreased 224.68 11.09 261 384788 8763 70534632
International normalised ratio increased 224.05 11.09 79 384970 80647 70462748
Abdominal pain 222.72 11.09 1027 384022 341100 70202295
Panniculitis 222.21 11.09 282 384767 10394 70533001
Dizziness 218.78 11.09 1548 383501 462593 70080802
Granuloma skin 218.28 11.09 238 384811 7444 70535951
Cardiac failure congestive 211.65 11.09 254 384795 135203 70408192
Retinopathy 208.27 11.09 164 384885 3342 70540053
Therapeutic response decreased 204.14 11.09 740 384309 57713 70485682
Intentional overdose 201.75 11.09 144 384905 98291 70445104
Lupus nephritis 199.27 11.09 147 384902 2707 70540688
Respiratory arrest 196.82 11.09 29 385020 53904 70489491
Nodule 196.41 11.09 373 384676 19596 70523799
Cognitive disorder 196.23 11.09 45 385004 60911 70482484
Neoplasm progression 191.50 11.09 14 385035 45214 70498181
Pneumonia aspiration 190.78 11.09 51 384998 62238 70481157
Blood glucose increased 190.48 11.09 167 384882 102815 70440580
Polyarthritis 189.76 11.09 262 384787 10494 70532901
Balance disorder 188.47 11.09 129 384920 89999 70453396
Pyrexia 188.10 11.09 2250 382799 604702 69938693
Renal impairment 186.94 11.09 308 384741 143629 70399766
Pancytopenia 185.61 11.09 335 384714 150772 70392623
Hypoglycaemia 184.44 11.09 145 384904 94219 70449176
Hepatic function abnormal 182.86 11.09 70 384979 67926 70475469
Vomiting 182.51 11.09 2202 382847 590909 69952486
Pulmonary embolism 182.25 11.09 356 384693 155511 70387884
Suicide attempt 181.19 11.09 103 384946 79407 70463988
Herpes zoster 178.03 11.09 924 384125 84311 70459084
Adverse event 175.11 11.09 629 384420 48832 70494563
Tenosynovitis 174.78 11.09 290 384759 13686 70529709
Dysphagia 174.75 11.09 213 384836 112621 70430774
Multiple sclerosis relapse 174.70 11.09 16 385033 43001 70500394
Foot deformity 174.47 11.09 362 384687 20293 70523102
Multiple organ dysfunction syndrome 174.32 11.09 199 384850 108316 70435079
Rheumatic fever 173.85 11.09 330 384719 17330 70526065
Melaena 172.86 11.09 46 385003 56309 70487086
Disorientation 170.77 11.09 51 384998 57872 70485523
Respiratory failure 169.61 11.09 419 384630 168316 70375079
Deformity 169.27 11.09 217 384832 8080 70535315
Hyperhidrosis 168.62 11.09 284 384765 131302 70412093
Joint effusion 168.45 11.09 302 384747 15175 70528220
Acute myocardial infarction 168.14 11.09 93 384956 72794 70470601
Blood bilirubin increased 167.29 11.09 58 384991 59843 70483552
Osteoporosis 167.26 11.09 615 384434 48292 70495103
Maculopathy 167.22 11.09 128 384921 2498 70540897
Cerebral haemorrhage 167.06 11.09 43 385006 53821 70489574
Ascites 166.53 11.09 79 384970 67468 70475927
Disturbance in attention 166.30 11.09 19 385030 42875 70500520
Oedema peripheral 165.93 11.09 656 384393 227435 70315960
Product dose omission issue 164.27 11.09 616 384433 216852 70326543
Sedation 164.05 11.09 28 385021 46703 70496692
Joint injury 162.17 11.09 413 384636 26519 70516876
Blood pressure decreased 160.26 11.09 156 384893 91359 70452036
Hypoxia 160.15 11.09 162 384887 93182 70450213
Stomatitis 158.73 11.09 1218 383831 127293 70416102
Unresponsive to stimuli 158.13 11.09 43 385006 51888 70491507
Blood cholesterol increased 156.04 11.09 730 384319 63874 70479521
Hyperglycaemia 155.85 11.09 78 384971 64594 70478801
Encephalopathy 155.29 11.09 70 384979 61591 70481804
Urinary tract infection 155.17 11.09 758 384291 248011 70295384
Asthenia 154.78 11.09 1663 383386 456003 70087392
Fine motor skill dysfunction 152.15 11.09 161 384888 4863 70538532
Haemoglobin decreased 151.16 11.09 587 384462 204572 70338823
Dysarthria 150.39 11.09 75 384974 62238 70481157
Blood creatinine increased 148.53 11.09 349 384700 142652 70400743
Restlessness 148.42 11.09 25 385024 42103 70501292
Swollen joint count increased 146.14 11.09 265 384784 13435 70529960
Loss of consciousness 145.54 11.09 401 384648 155315 70388080
Pulmonary oedema 145.53 11.09 139 384910 82139 70461256
Jaundice 144.34 11.09 46 385003 50062 70493333
Sopor 143.72 11.09 6 385043 31261 70512134
Hepatic failure 142.66 11.09 67 384982 57558 70485837
Long QT syndrome 142.65 11.09 160 384889 5167 70538228
Rheumatoid factor negative 142.52 11.09 84 384965 1038 70542357
Coronary artery disease 141.90 11.09 82 384967 62654 70480741
Aggression 140.39 11.09 44 385005 48402 70494993
Adverse drug reaction 140.19 11.09 618 384431 52726 70490669
Mental status changes 139.17 11.09 85 384964 63016 70480379
Dyskinesia 139.03 11.09 27 385022 41047 70502348
Pleural effusion 139.00 11.09 323 384726 132541 70410854
Finger deformity 138.80 11.09 169 384880 5967 70537428
Urinary retention 138.04 11.09 56 384993 52464 70490931
Apparent death 136.85 11.09 117 384932 2687 70540708
Blood urea increased 136.10 11.09 40 385009 45869 70497526
Chest pain 135.44 11.09 804 384245 250456 70292939
Palmar-plantar erythrodysaesthesia syndrome 135.15 11.09 7 385042 30240 70513155
X-ray abnormal 133.55 11.09 111 384938 2449 70540946
Diarrhoea 133.06 11.09 3239 381810 780102 69763293
Accidental overdose 132.61 11.09 17 385032 35104 70508291
Haemorrhage 131.06 11.09 157 384892 83658 70459737
Haematuria 130.25 11.09 93 384956 63480 70479915
Cytokine release syndrome 129.10 11.09 3 385046 26464 70516931
Electrocardiogram QT prolonged 127.28 11.09 833 384216 82684 70460711
Muscle spasms 127.24 11.09 420 384629 153626 70389769
Myocardial infarction 127.13 11.09 490 384559 171155 70372240
Joint destruction 126.11 11.09 141 384908 4537 70538858
Epilepsy 126.10 11.09 28 385021 38756 70504639
Myalgia 125.82 11.09 477 384572 167415 70375980
Bone marrow failure 124.42 11.09 55 384994 48955 70494440
Ulcer 124.18 11.09 364 384685 25390 70518005
Abnormal behaviour 123.60 11.09 20 385029 34689 70508706
Pain in extremity 121.71 11.09 2477 382572 325605 70217790
Orthostatic hypotension 120.82 11.09 65 384984 51678 70491717
Serotonin syndrome 120.70 11.09 39 385010 42075 70501320
Physical disability 120.68 11.09 110 384939 2757 70540638
Neuropathy peripheral 120.65 11.09 324 384725 126572 70416823
Lethargy 119.76 11.09 139 384910 75111 70468284
Diabetic ketoacidosis 119.59 11.09 15 385034 31497 70511898
Irritability 117.62 11.09 31 385018 38194 70505201
Hypomagnesaemia 116.39 11.09 38 385011 40726 70502669
Neuroleptic malignant syndrome 116.26 11.09 6 385043 26001 70517394
Drug withdrawal syndrome 116.17 11.09 19 385030 32696 70510699
Diverticulitis 115.41 11.09 491 384558 41243 70502152
Drug effective for unapproved indication 115.29 11.09 134 384915 4501 70538894
Bone density decreased 114.92 11.09 216 384833 11258 70532137
Tuberculin test positive 114.62 11.09 113 384936 3133 70540262
Rectal haemorrhage 114.35 11.09 113 384936 65718 70477677
Glaucoma 113.70 11.09 282 384767 17810 70525585
Respiratory distress 113.21 11.09 79 384970 54571 70488824
Elbow deformity 112.98 11.09 80 384969 1378 70542017
Wrong technique in product usage process 111.38 11.09 125 384924 68573 70474822
Haematemesis 110.05 11.09 64 384985 48733 70494662
Tubulointerstitial nephritis 109.33 11.09 23 385026 33053 70510342
Blood alkaline phosphatase increased 109.29 11.09 94 384955 58427 70484968
Joint laxity 108.89 11.09 95 384954 2244 70541151
Blood calcium decreased 108.82 11.09 14 385035 28832 70514563
Circulatory collapse 108.71 11.09 29 385020 35445 70507950
Upper gastrointestinal haemorrhage 108.66 11.09 34 385015 37443 70505952
Oral mucosal exfoliation 108.22 11.09 77 384972 1337 70542058
Shoulder arthroplasty 107.96 11.09 105 384944 2862 70540533
Spinal stenosis 107.94 11.09 243 384806 14410 70528985
Generalised tonic-clonic seizure 106.95 11.09 46 385003 41615 70501780
Neurotoxicity 106.63 11.09 17 385032 29809 70513586
Renal phospholipidosis 106.55 11.09 35 385014 80 70543315
SLE arthritis 106.07 11.09 54 384995 488 70542907
Vision blurred 105.82 11.09 223 384826 94761 70448634
Skin necrosis 105.63 11.09 257 384792 16034 70527361
Bone cyst 105.12 11.09 102 384947 2772 70540623
Rheumatoid lung 105.02 11.09 111 384938 3348 70540047
Altered state of consciousness 104.65 11.09 43 385006 39979 70503416
Blood creatine phosphokinase increased 104.30 11.09 107 384942 61156 70482239
Osteonecrosis of jaw 104.10 11.09 46 385003 40956 70502439
Exposure during pregnancy 103.64 11.09 823 384226 86894 70456501
Gamma-glutamyltransferase increased 102.72 11.09 75 384974 50610 70492785
Human antichimeric antibody positive 102.35 11.09 76 384973 1414 70541981
Therapy non-responder 101.72 11.09 741 384308 76174 70467221
Hypokalaemia 101.36 11.09 368 384681 130820 70412575
Acute myeloid leukaemia 101.27 11.09 22 385027 30918 70512477
Lymphocyte count decreased 101.21 11.09 55 384994 43484 70499911
Contusion 99.32 11.09 1098 383951 126938 70416457
Mucosal inflammation 98.91 11.09 134 384915 67716 70475679
Tumour lysis syndrome 98.51 11.09 4 385045 21356 70522039
Fluid retention 97.75 11.09 120 384929 63265 70480130
Metastases to bone 97.44 11.09 6 385043 22370 70521025
Status epilepticus 97.28 11.09 10 385039 24516 70518879
Chronic kidney disease 96.92 11.09 113 384936 60944 70482451
Acute respiratory failure 95.67 11.09 90 384959 53575 70489820
Seronegative arthritis 94.81 11.09 104 384945 3275 70540120
Sleep disorder 94.62 11.09 677 384372 69195 70474200
Body height below normal 94.38 11.09 80 384969 1815 70541580
Sciatica 93.90 11.09 321 384728 24306 70519089
Haematoma 93.84 11.09 75 384974 48343 70495052
Neutropenic sepsis 93.79 11.09 12 385037 24818 70518577
Hepatitis 92.29 11.09 524 384525 49456 70493939
Suicidal ideation 92.12 11.09 147 384902 69449 70473946
Cerebral infarction 92.00 11.09 60 384989 42949 70500446
Intentional self-injury 91.25 11.09 29 385020 31621 70511774
Dysuria 91.20 11.09 69 384980 45725 70497670
Deep vein thrombosis 90.82 11.09 304 384745 110738 70432657
Subacute cutaneous lupus erythematosus 90.34 11.09 99 384950 3114 70540281
Juvenile idiopathic arthritis 90.13 11.09 133 384916 5667 70537728
Gastrooesophageal reflux disease 90.11 11.09 227 384822 90612 70452783
Musculoskeletal deformity 89.96 11.09 64 384985 1111 70542284
Cytomegalovirus infection 89.86 11.09 52 384997 39706 70503689
Drug ineffective for unapproved indication 89.79 11.09 431 384618 38107 70505288
Chills 89.72 11.09 442 384607 144344 70399051
Confusional state 89.42 11.09 1050 383999 283348 70260047
Colitis 89.07 11.09 130 384919 63684 70479711
Liver function test increased 88.07 11.09 391 384658 33456 70509939
Disseminated intravascular coagulation 88.01 11.09 36 385013 33562 70509833
Emotional distress 87.88 11.09 46 385003 37142 70506253
Surgical failure 87.18 11.09 55 384994 774 70542621
Intentional product misuse 86.89 11.09 189 384860 79406 70463989
Bone pain 86.25 11.09 89 384960 50733 70492662
Fatigue 86.05 11.09 5375 379674 818944 69724451
Cholelithiasis 86.03 11.09 78 384971 47262 70496133
Night sweats 86 11.09 466 384583 43218 70500177
Subdural haematoma 85.98 11.09 26 385023 29272 70514123
Metastases to liver 85.52 11.09 18 385031 25860 70517535
Joint arthroplasty 84.65 11.09 86 384963 2474 70540921
Red blood cell sedimentation rate 84.22 11.09 118 384931 4792 70538603
Aphasia 83.81 11.09 67 384982 43182 70500213
Arthrodesis 83.76 11.09 81 384968 2192 70541203
Arrhythmia 83.75 11.09 109 384940 56034 70487361
Device expulsion 83.43 11.09 11 385038 22235 70521160
Skin ulcer 83.20 11.09 496 384553 47649 70495746
Cardiogenic shock 82.75 11.09 47 385002 36260 70507135
Small intestinal obstruction 81.78 11.09 17 385032 24638 70518757
Hallucination, visual 80.89 11.09 29 385020 29308 70514087
Loose body in joint 80.60 11.09 62 384987 1219 70542176
Abdominal distension 80.59 11.09 294 384755 104375 70439020
Dysgeusia 80.32 11.09 90 384959 49412 70493983
Wrist deformity 79.47 11.09 72 384977 1790 70541605
Chest discomfort 78.63 11.09 377 384672 124004 70419391
Colitis microscopic 78.61 11.09 160 384889 8845 70534550
Dislocation of vertebra 78.51 11.09 114 384935 4786 70538609
Transient ischaemic attack 78.49 11.09 80 384969 45864 70497531
Hospitalisation 78.33 11.09 211 384838 82357 70461038
Epicondylitis 77.72 11.09 73 384976 1903 70541492
Haemoptysis 77.67 11.09 99 384950 51353 70492042
Eye disorder 76.70 11.09 268 384781 20517 70522878
Gastric disorder 76.43 11.09 371 384678 32951 70510444
Investigation abnormal 76.38 11.09 70 384979 1767 70541628
Clostridium difficile colitis 76.06 11.09 31 385018 28965 70514430
Poisoning deliberate 76.06 11.09 4 385045 17056 70526339
Vertigo 75.87 11.09 140 384909 62503 70480892
Device related infection 75.77 11.09 40 385009 32145 70511250
Adverse reaction 75.53 11.09 153 384896 8429 70534966
Hypophosphataemia 75.48 11.09 3 385046 16323 70527072
Enthesopathy 75.37 11.09 176 384873 10693 70532702
Blood lactate dehydrogenase increased 75.14 11.09 49 385000 35078 70508317
Product quality issue 74.92 11.09 36 385013 30525 70512870
Drug use disorder 73.75 11.09 147 384902 8004 70535391
Angioedema 73.67 11.09 157 384892 66453 70476942
Asthma 73.54 11.09 371 384678 120422 70422973
Withdrawal syndrome 73.27 11.09 22 385027 24882 70518513
Myelosuppression 73.16 11.09 36 385013 30109 70513286
Angina pectoris 73.14 11.09 93 384956 48290 70495105
Haematochezia 72.97 11.09 182 384867 72899 70470496
Tachypnoea 72.90 11.09 32 385017 28606 70514789
Hyperthyroidism 72.85 11.09 11 385038 20080 70523315
Synovial cyst 72.41 11.09 152 384897 8590 70534805
Breast cancer stage III 72.23 11.09 130 384919 6551 70536844
Product administration error 72.04 11.09 35 385014 29488 70513907
Incorrect dose administered 71.53 11.09 160 384889 66559 70476836
Flatulence 70.47 11.09 62 384987 38119 70505276
Pallor 70.39 11.09 71 384978 40903 70502492
Depression 70.34 11.09 715 384334 198259 70345136
Flushing 69.93 11.09 221 384828 81951 70461444
Onychomadesis 69.51 11.09 98 384951 4003 70539392
Extrapyramidal disorder 69.47 11.09 14 385035 20736 70522659
Myoclonus 69.42 11.09 28 385021 26327 70517068
Onychomycosis 69.22 11.09 130 384919 6771 70536624
Cyanosis 69.19 11.09 20 385029 23186 70520209
Urinary incontinence 69.18 11.09 62 384987 37780 70505615
Cardiac disorder 69.14 11.09 136 384913 59279 70484116
Hypervolaemia 69.13 11.09 68 384981 39638 70503757
Sensitivity to weather change 68.75 11.09 135 384914 7270 70536125
Dry skin 68.63 11.09 124 384925 55807 70487588
Electrolyte imbalance 68.40 11.09 30 385019 26831 70516564
Pancreatitis acute 68.29 11.09 87 384962 45137 70498258
Pancreatitis 68.24 11.09 149 384900 62519 70480876
Intestinal obstruction 68.16 11.09 66 384983 38759 70504636
Muscle twitching 67.17 11.09 13 385036 19814 70523581
Gastritis 67.10 11.09 86 384963 44505 70498890
Ileus 66.75 11.09 24 385025 24213 70519182
Hypothermia 66.68 11.09 15 385034 20579 70522816
Chronic obstructive pulmonary disease 66.65 11.09 208 384841 77433 70465962
Ischaemic stroke 65.91 11.09 43 385006 30777 70512618
Haemorrhage intracranial 65.79 11.09 26 385023 24751 70518644
COVID-19 treatment 65.70 11.09 37 385012 417 70542978
Lupus-like syndrome 65.63 11.09 173 384876 11342 70532053
Viral upper respiratory tract infection 65.55 11.09 144 384905 8398 70534997
Full blood count decreased 65.34 11.09 24 385025 23894 70519501
Basal cell carcinoma 65.34 11.09 358 384691 33340 70510055
Ear pain 65.26 11.09 310 384739 27289 70516106
Myocardial ischaemia 64.91 11.09 25 385024 24175 70519220
Palpitations 64.70 11.09 345 384704 110408 70432987
Prostate cancer 64.60 11.09 45 385004 31118 70512277
Blood iron abnormal 64.31 11.09 53 384996 1155 70542240
Terminal state 64.26 11.09 101 384948 4551 70538844
Device dislocation 64.22 11.09 21 385028 22486 70520909
Inappropriate antidiuretic hormone secretion 64.19 11.09 23 385026 23253 70520142
Cough 63.89 11.09 1314 383735 324063 70219332
Drug eruption 63.88 11.09 400 384649 39096 70504299
Paranoia 63.76 11.09 9 385040 17279 70526116
Full blood count abnormal 63.76 11.09 54 384995 33824 70509571
Multiple fractures 63.62 11.09 124 384925 6641 70536754
White blood cell count increased 63.60 11.09 181 384868 69392 70474003
Wheelchair user 63.60 11.09 107 384942 5107 70538288
Poisoning 62.99 11.09 22 385027 22600 70520795
Swollen tongue 62.72 11.09 65 384984 36981 70506414
Bone swelling 62.71 11.09 58 384991 1482 70541913
Septic shock 62.66 11.09 355 384694 111903 70431492
Blood potassium decreased 62.62 11.09 83 384966 42338 70501057
Cholestasis 62.52 11.09 102 384947 47770 70495625
Intestinal sepsis 62.38 11.09 44 385005 753 70542642
Deafness transitory 62.11 11.09 47 385002 901 70542494
Hypophagia 61.70 11.09 81 384968 41489 70501906
Femur fracture 61.64 11.09 371 384678 35761 70507634
Dyspnoea exertional 61.23 11.09 219 384830 78211 70465184
Alanine aminotransferase abnormal 60.88 11.09 135 384914 7924 70535471
Coordination abnormal 60.11 11.09 8 385041 16058 70527337
Neoplasm malignant 60.09 11.09 312 384737 28462 70514933
Blood sodium decreased 60.09 11.09 48 385001 30950 70512445
Dialysis 59.83 11.09 11 385038 17391 70526004
Delirium 59.82 11.09 206 384843 74408 70468987
Hepatocellular injury 59.45 11.09 99 384950 45992 70497403
Bone density abnormal 59.33 11.09 76 384973 2827 70540568
Paraesthesia 59.16 11.09 505 384544 145032 70398363
Type 2 diabetes mellitus 59.03 11.09 426 384623 43654 70499741
Second primary malignancy 58.37 11.09 3 385046 13048 70530347
Mouth ulceration 58.15 11.09 352 384697 33997 70509398
Neck mass 57.99 11.09 91 384958 4095 70539300
Erectile dysfunction 57.98 11.09 4 385045 13558 70529837
Miosis 57.91 11.09 5 385044 14096 70529299
Hypoalbuminaemia 57.90 11.09 16 385033 19106 70524289
Presyncope 57.59 11.09 71 384978 37367 70506028
Anti-cyclic citrullinated peptide antibody 57.54 11.09 81 384968 3304 70540091
Pemphigoid 57.51 11.09 5 385044 14017 70529378
Psychotic disorder 57.47 11.09 72 384977 37629 70505766
Ataxia 57.45 11.09 27 385022 23190 70520205
Graft versus host disease 57.38 11.09 7 385042 15016 70528379
Pulmonary toxicity 57.29 11.09 158 384891 10640 70532755
Retinitis 57.02 11.09 90 384959 4070 70539325
Presbyacusis 57.02 11.09 71 384978 2566 70540829
Aspiration 56.98 11.09 13 385036 17662 70525733
Thyroid neoplasm 56.96 11.09 75 384974 2868 70540527
Dementia 56.92 11.09 25 385024 22340 70521055
Cellulitis 56.77 11.09 310 384739 98618 70444777
Pulmonary congestion 56.70 11.09 33 385016 25121 70518274
Aplastic anaemia 56.54 11.09 11 385038 16705 70526690
Limb discomfort 56.53 11.09 314 384735 29391 70514004
Obstructive airways disorder 56.43 11.09 36 385013 26077 70517318
Fear of injection 56.42 11.09 117 384932 6555 70536840
Accidental exposure to product 56.20 11.09 42 385007 28009 70515386
Hepatic encephalopathy 55.85 11.09 25 385024 22093 70521302
Muscle rigidity 55.74 11.09 16 385033 18634 70524761
Glycosylated haemoglobin increased 55.64 11.09 13 385036 17378 70526017
Coagulopathy 55.55 11.09 59 384990 33190 70510205
Haemodialysis 55.53 11.09 13 385036 17353 70526042
Premature delivery 55.34 11.09 246 384803 21058 70522337
Neck pain 55.08 11.09 579 384470 66078 70477317
Osteoporotic fracture 54.85 11.09 84 384965 3700 70539695
Malnutrition 54.47 11.09 21 385028 20296 70523099
Speech disorder 54.46 11.09 121 384928 50459 70492936
Tenderness 54.41 11.09 244 384805 20966 70522429
Mental disorder 54.40 11.09 44 385005 28196 70515199
Ovarian neoplasm 54.25 11.09 36 385013 555 70542840
Shock 53.86 11.09 85 384964 40340 70503055
Exostosis 53.83 11.09 186 384863 14159 70529236
Liver injury 53.47 11.09 394 384655 40641 70502754
Agranulocytosis 53.43 11.09 85 384964 40213 70503182
Acute coronary syndrome 53.43 11.09 21 385028 20058 70523337
Head injury 53.31 11.09 64 384985 34077 70509318
Blood triglycerides increased 53.27 11.09 20 385029 19644 70523751
Shock haemorrhagic 53.26 11.09 16 385033 18090 70525305
Bladder cancer 53.01 11.09 14 385035 17228 70526167
Delusion 52.74 11.09 19 385030 19146 70524249
Pericardial effusion 52.72 11.09 91 384958 41685 70501710
Subarachnoid haemorrhage 52.56 11.09 20 385029 19484 70523911
Hemiparesis 52.39 11.09 56 384993 31413 70511982
Dystonia 51.80 11.09 21 385028 19685 70523710
Anger 51.73 11.09 12 385037 16120 70527275
Blood pressure systolic abnormal 51.63 11.09 171 384878 12738 70530657
Hepatic enzyme abnormal 51.47 11.09 109 384940 6198 70537197
Labelled drug-drug interaction medication error 51.14 11.09 34 385015 24093 70519302
Weight increased 50.56 11.09 1696 383353 240635 70302760
Multiple sclerosis 50.47 11.09 38 385011 25247 70518148
Thrombotic microangiopathy 50.31 11.09 17 385032 17831 70525564
International normalised ratio fluctuation 50.28 11.09 74 384975 3145 70540250
Glomerular filtration rate decreased 50.05 11.09 25 385024 20731 70522664
Parkinsonism 49.95 11.09 11 385038 15314 70528081
Urine output decreased 49.91 11.09 15 385034 16955 70526440
Anticipatory anxiety 49.43 11.09 42 385007 956 70542439
Mesenteritis 49.43 11.09 26 385023 253 70543142
Neck deformity 49.06 11.09 54 384995 1707 70541688
Gait inability 48.97 11.09 430 384619 46745 70496650
Lyme disease 48.91 11.09 69 384980 2820 70540575
Acute hepatic failure 48.62 11.09 47 385002 27625 70515770
Brain oedema 48.30 11.09 34 385015 23384 70520011
Spinal column injury 48.22 11.09 57 384992 1950 70541445
Bloody discharge 48.03 11.09 53 384996 1680 70541715
Mydriasis 48.01 11.09 14 385035 16139 70527256
Injection site reaction 47.98 11.09 447 384602 49405 70493990
Complication associated with device 47.85 11.09 13 385036 15700 70527695
Pulmonary arterial hypertension 47.76 11.09 65 384984 32790 70510605
Metastases to lung 47.70 11.09 15 385034 16469 70526926
Drug resistance 47.45 11.09 84 384965 38106 70505289
Myelodysplastic syndrome 47.40 11.09 55 384994 29730 70513665
Acquired pigmented retinopathy 47.23 11.09 12 385037 4 70543391
Hypothyroidism 47.21 11.09 112 384937 45643 70497752
Lower gastrointestinal haemorrhage 47.10 11.09 11 385038 14709 70528686
Pleural thickening 47.00 11.09 67 384982 2765 70540630
Bacteraemia 46.77 11.09 54 384995 29255 70514140
Pleural fibrosis 46.63 11.09 82 384967 4057 70539338
Metastases to central nervous system 46.62 11.09 12 385037 15022 70528373
Faeces discoloured 46.57 11.09 46 385003 26763 70516632
Troponin increased 46.53 11.09 16 385033 16598 70526797
Muscle spasticity 46.44 11.09 221 384828 19468 70523927
Bone disorder 46.22 11.09 203 384846 17287 70526108
Infusion site reaction 46.17 11.09 66 384983 2731 70540664
Leukocytosis 45.98 11.09 91 384958 39577 70503818
Bronchospasm 45.82 11.09 34 385015 22758 70520637
Hypersomnia 45.74 11.09 28 385021 20736 70522659
Lipase increased 45.71 11.09 13 385036 15233 70528162
Pulmonary hypertension 45.59 11.09 117 384932 46419 70496976
Bursitis 45.57 11.09 274 384775 26399 70516996
Live birth 45.20 11.09 171 384878 13608 70529787
Polyuria 44.97 11.09 9 385040 13397 70529998
Cataract 44.87 11.09 481 384568 55164 70488231
Salivary hypersecretion 44.80 11.09 8 385041 12917 70530478
Arteriosclerosis coronary artery 44.75 11.09 16 385033 16199 70527196
Neutrophil count increased 44.26 11.09 48 385001 26747 70516648
Hyperammonaemia 44.11 11.09 3 385046 10290 70533105
Mania 44.02 11.09 19 385030 17155 70526240
Abdominal pain lower 43.94 11.09 53 384996 28163 70515232
Coeliac disease 43.86 11.09 128 384921 8905 70534490
Cutaneous lupus erythematosus 43.81 11.09 65 384984 2783 70540612
Blood glucose decreased 43.66 11.09 40 385009 24119 70519276
Transfusion 43.48 11.09 24 385025 18812 70524583
Petechiae 43.43 11.09 25 385024 19147 70524248
Blood pressure diastolic abnormal 43.31 11.09 183 384866 15321 70528074
Ventricular fibrillation 43.21 11.09 50 384999 27061 70516334
Joint lock 43.20 11.09 66 384983 2901 70540494
Brain injury 42.97 11.09 4 385045 10613 70532782
Sinus bradycardia 42.83 11.09 39 385010 23584 70519811
Acidosis 42.55 11.09 23 385026 18240 70525155
Swelling face 42.55 11.09 187 384862 62977 70480418
Renal tubular necrosis 42.31 11.09 38 385011 23133 70520262
Weight decreased 42.30 11.09 1323 383726 309165 70234230
Haematotoxicity 42.24 11.09 11 385038 13663 70529732
Limb deformity 42.12 11.09 71 384978 3394 70540001
Pollakiuria 42.12 11.09 73 384976 33388 70510007
Hypovolaemia 42.11 11.09 17 385032 15976 70527419
Blood magnesium decreased 42.07 11.09 14 385035 14827 70528568
Tuberculosis 42.06 11.09 176 384873 14672 70528723
Device issue 41.99 11.09 41 385008 23984 70519411
Mycotic allergy 41.92 11.09 40 385009 1064 70542331
Maternal exposure timing unspecified 41.92 11.09 81 384968 4310 70539085
Arteriosclerosis 41.71 11.09 19 385030 16619 70526776
Clostridium difficile infection 41.67 11.09 93 384956 38723 70504672
Lupus vasculitis 41.58 11.09 29 385020 487 70542908
Asphyxia 41.58 11.09 4 385045 10338 70533057
Prothrombin time prolonged 41.35 11.09 18 385031 16172 70527223
Aspartate aminotransferase increased 41.33 11.09 465 384584 126513 70416882
Drug specific antibody 41.29 11.09 57 384992 2282 70541113
Product use in unapproved indication 41.23 11.09 1444 383605 206034 70337361
Incontinence 41.17 11.09 10 385039 13018 70530377
Drug level increased 41.13 11.09 85 384964 36384 70507011
Infective pulmonary exacerbation of cystic fibrosis 41.13 11.09 8 385041 12150 70531245
Hypertensive crisis 41.02 11.09 27 385022 19235 70524160
Peritonitis 40.88 11.09 49 385000 26110 70517285
Sinus tachycardia 40.88 11.09 76 384973 33837 70509558
Ejection fraction decreased 40.68 11.09 65 384984 30697 70512698
Pancreatic carcinoma 40.59 11.09 10 385039 12894 70530501
End stage renal disease 40.58 11.09 6 385043 11127 70532268
Diabetes mellitus inadequate control 40.33 11.09 38 385011 22607 70520788
Stevens-Johnson syndrome 40.23 11.09 84 384965 35823 70507572
Hypocalcaemia 40.05 11.09 118 384931 44741 70498654
Dermatomyositis 39.35 11.09 69 384980 3406 70539989
Antibody test positive 39.27 11.09 58 384991 2473 70540922
Skin exfoliation 39.14 11.09 134 384915 48492 70494903
Feeling cold 38.80 11.09 49 385000 25521 70517874
Metastases to lymph nodes 38.70 11.09 3 385046 9235 70534160
Feeling hot 38.59 11.09 135 384914 48535 70494860
Pathogen resistance 38.58 11.09 12 385037 13267 70530128
Haemorrhagic stroke 38.56 11.09 5 385044 10237 70533158
Gastrointestinal pain 38.53 11.09 116 384933 8211 70535184
Nightmare 38.50 11.09 38 385011 22118 70521277
Hair follicle tumour benign 38.41 11.09 26 385023 415 70542980
Mental impairment 38.38 11.09 23 385026 17232 70526163
Toxic epidermal necrolysis 38.33 11.09 100 384949 39457 70503938
Anal incontinence 38.08 11.09 21 385028 16469 70526926
Polyneuropathy 38.06 11.09 36 385013 21379 70522016
Nervous system disorder 37.98 11.09 45 385004 24101 70519294
Activated partial thromboplastin time prolonged 37.83 11.09 13 385036 13492 70529903
Drug tolerance 37.75 11.09 107 384942 7321 70536074
Cholecystitis 37.74 11.09 34 385015 20667 70522728
Dry eye 37.62 11.09 302 384747 31980 70511415
Anhedonia 37.60 11.09 15 385034 14198 70529197
Hyperuricaemia 37.55 11.09 7 385042 10959 70532436
Acute pulmonary oedema 37.42 11.09 13 385036 13399 70529996
Drug level decreased 37.41 11.09 11 385038 12613 70530782
Faecaloma 37.26 11.09 6 385043 10445 70532950
Nail disorder 37.25 11.09 133 384916 10291 70533104
Overlap syndrome 37.24 11.09 32 385017 740 70542655
Joint dislocation 37.15 11.09 167 384882 14364 70529031
Toxic encephalopathy 37.04 11.09 6 385043 10400 70532995
Oesophagitis 36.95 11.09 41 385008 22611 70520784
Pulmonary thrombosis 36.69 11.09 139 384910 11069 70532326
Suspected suicide 36.65 11.09 3 385046 8831 70534564
Depressed mood 36.48 11.09 119 384930 43701 70499694
Feeling abnormal 36.44 11.09 548 384501 141771 70401624
Extremity contracture 36.38 11.09 45 385004 1615 70541780
Laryngeal disorder 36.26 11.09 35 385014 945 70542450
Cholangitis 36.23 11.09 9 385040 11540 70531855
Lip swelling 36.22 11.09 82 384967 33972 70509423
Granulocytopenia 36.03 11.09 7 385042 10640 70532755
Hallucination, auditory 36.00 11.09 28 385021 18300 70525095
Duodenal ulcer 35.95 11.09 19 385030 15261 70528134
Gastric haemorrhage 35.87 11.09 16 385033 14169 70529226
Transplant rejection 35.39 11.09 28 385021 18143 70525252
Pustular psoriasis 35.24 11.09 78 384971 4572 70538823
Mood altered 35.21 11.09 23 385026 16452 70526943
Psychomotor hyperactivity 35.14 11.09 20 385029 15413 70527982
Peripheral sensory neuropathy 35.08 11.09 11 385038 12099 70531296
Renal injury 35.04 11.09 22 385027 16072 70527323
Face oedema 35.02 11.09 53 384996 25586 70517809
Oliguria 35.00 11.09 19 385030 15032 70528363
Anuria 34.97 11.09 33 385016 19620 70523775
Wrist surgery 34.91 11.09 31 385018 750 70542645
Failure to thrive 34.84 11.09 8 385041 10821 70532574
Staphylococcal infection 34.83 11.09 160 384889 53244 70490151
Prostatic specific antigen increased 34.74 11.09 5 385044 9461 70533934
Immune thrombocytopenia 34.60 11.09 23 385026 16301 70527094
Transaminases abnormal 34.54 11.09 31 385018 761 70542634
Infiltration anaesthesia 34.53 11.09 17 385032 142 70543253
Sudden death 34.49 11.09 38 385011 21026 70522369
Histoplasmosis disseminated 34.43 11.09 49 385000 2019 70541376
Phospholipidosis 34.41 11.09 16 385033 116 70543279
Antinuclear antibody positive 34.31 11.09 98 384951 6735 70536660
Oesophageal carcinoma 34.25 11.09 5 385044 9361 70534034
Wheezing 34.25 11.09 336 384713 93834 70449561
Personality change 34.20 11.09 4 385045 8866 70534529
Pneumonitis 34.18 11.09 166 384883 54431 70488964
Cytology abnormal 34.07 11.09 22 385027 323 70543072
Facet joint syndrome 33.99 11.09 91 384958 6022 70537373
Anovulatory cycle 33.95 11.09 16 385033 120 70543275
Urticarial vasculitis 33.92 11.09 27 385022 559 70542836
Pulmonary haemosiderosis 33.74 11.09 12 385037 38 70543357
Diffuse alopecia 33.56 11.09 28 385021 621 70542774
Post transplant lymphoproliferative disorder 33.51 11.09 8 385041 10537 70532858
Therapy cessation 33.51 11.09 84 384965 33592 70509803
Alanine aminotransferase increased 33.40 11.09 581 384468 146899 70396496
Diarrhoea haemorrhagic 33.37 11.09 11 385038 11719 70531676
Post procedural haemorrhage 33.35 11.09 14 385035 12852 70530543
Butterfly rash 33.35 11.09 40 385009 1390 70542005
Hyperthermia 33.35 11.09 25 385024 16646 70526749
Pneumonia viral 33.30 11.09 110 384939 8182 70535213
Pulseless electrical activity 33.27 11.09 15 385034 13200 70530195
Device difficult to use 32.99 11.09 9 385040 10840 70532555
Foot operation 32.97 11.09 78 384971 4779 70538616
Latent tuberculosis 32.82 11.09 60 384989 3061 70540334
Ankle operation 32.77 11.09 34 385015 1003 70542392
Lupus myocarditis 32.73 11.09 14 385035 81 70543314
Colitis ischaemic 32.65 11.09 18 385031 14119 70529276
Enterocolitis 32.63 11.09 15 385034 13051 70530344
Dyslipidaemia 32.29 11.09 7 385042 9853 70533542
Product prescribing error 32.27 11.09 106 384943 38846 70504549
Gastric cancer 32.24 11.09 5 385044 8950 70534445
COVID-19 31.99 11.09 776 384273 104981 70438414
Mass excision 31.97 11.09 21 385028 318 70543077
Haemodynamic instability 31.94 11.09 23 385026 15635 70527760
Skin reaction 31.91 11.09 156 384893 13893 70529502
Victim of child abuse 31.91 11.09 32 385017 906 70542489
Device leakage 31.75 11.09 6 385043 9302 70534093
Metabolic encephalopathy 31.69 11.09 4 385045 8359 70535036
Breast cancer metastatic 31.65 11.09 8 385041 10138 70533257
Pneumocystis jirovecii pneumonia 31.54 11.09 73 384976 30009 70513386
Hepatic cancer 31.46 11.09 7 385042 9676 70533719
Right ventricular failure 31.45 11.09 45 385004 22229 70521166
Tenosynovitis stenosans 31.33 11.09 50 384999 2283 70541112
Therapy interrupted 31.31 11.09 54 384995 24748 70518647
Coronary artery stenosis 31.28 11.09 12 385037 11632 70531763
Gout 31 11.09 48 385001 22958 70520437
Cutaneous vasculitis 30.86 11.09 98 384951 7140 70536255
Cushingoid 30.81 11.09 108 384941 8280 70535115
Kidney transplant rejection 30.79 11.09 8 385041 9953 70533442
Sleep apnoea syndrome 30.71 11.09 84 384965 32629 70510766
Synovial fluid analysis 30.70 11.09 44 385005 1825 70541570
Heart rate irregular 30.53 11.09 73 384976 29670 70513725
Myopathy toxic 30.47 11.09 32 385017 958 70542437
Colitis ulcerative 30.45 11.09 89 384960 33834 70509561
Restrictive cardiomyopathy 30.25 11.09 32 385017 966 70542429
Lung infiltration 30.22 11.09 44 385005 21580 70521815
Cartilage atrophy 30.22 11.09 16 385033 158 70543237
Bronchitis chronic 30.16 11.09 68 384981 4036 70539359
Nausea 30.11 11.09 4111 380938 847977 69695418
Blood magnesium increased 30.05 11.09 60 384989 3271 70540124
Hepatitis C 30.02 11.09 16 385033 12791 70530604
Optical coherence tomography abnormal 30.02 11.09 9 385040 13 70543382
C-reactive protein 29.97 11.09 46 385003 2030 70541365
Heart rate increased 29.89 11.09 401 384648 105747 70437648
Obesity 29.88 11.09 248 384801 26523 70516872
Wound infection 29.84 11.09 180 384869 17362 70526033
Cold sweat 29.78 11.09 29 385020 16987 70526408
Ear infection 29.78 11.09 259 384790 28077 70515318
Cytopenia 29.77 11.09 30 385019 17293 70526102
Needle issue 29.73 11.09 11 385038 10904 70532491
Vascular access complication 29.73 11.09 42 385007 1719 70541676
Inappropriate schedule of product administration 29.68 11.09 408 384641 107147 70436248
Device malfunction 29.55 11.09 36 385013 19048 70524347
Chorioretinitis 29.52 11.09 31 385018 928 70542467
Hypercalcaemia 29.50 11.09 301 384748 34084 70509311
Injection site pain 29.38 11.09 455 384594 117164 70426231
Eye swelling 29.28 11.09 52 384997 23562 70519833
Cardiac failure acute 29.24 11.09 31 385018 17456 70525939
Ileus paralytic 29.14 11.09 6 385043 8755 70534640
Peritonitis bacterial 29.12 11.09 7 385042 9177 70534218
Angina unstable 29.10 11.09 26 385023 15867 70527528
Hemiplegia 28.89 11.09 20 385029 13875 70529520
Leukoencephalopathy 28.86 11.09 3 385046 7291 70536104
Coronavirus infection 28.84 11.09 87 384962 6165 70537230
Osteopenia 28.83 11.09 172 384877 16525 70526870
Appendicitis 28.73 11.09 29 385020 16704 70526691
Respiratory disorder 28.72 11.09 332 384717 38791 70504604
Underdose 28.69 11.09 74 384975 29309 70514086
Supraventricular tachycardia 28.64 11.09 39 385010 19671 70523724
Aplasia 28.64 11.09 3 385046 7248 70536147
Respiratory acidosis 28.62 11.09 10 385039 10271 70533124
Partial seizures 28.61 11.09 5 385044 8200 70535195
Hepatic necrosis 28.60 11.09 6 385043 8640 70534755
Hypofibrinogenaemia 28.59 11.09 43 385006 1864 70541531
Multiple allergies 28.58 11.09 100 384949 7660 70535735
Lip dry 28.51 11.09 117 384932 9668 70533727
Deafness neurosensory 28.47 11.09 90 384959 6542 70536853
Device occlusion 28.32 11.09 11 385038 10584 70532811
Tender joint count 28.26 11.09 12 385037 68 70543327
Retching 28.24 11.09 27 385022 15952 70527443
Muscular weakness 28.19 11.09 555 384494 137781 70405614
Chromaturia 28.12 11.09 53 384996 23475 70519920
Panic attack 28.07 11.09 48 385001 22071 70521324
Intestinal polyp 27.94 11.09 43 385006 1902 70541493
Cutaneous coccidioidomycosis 27.88 11.09 9 385040 19 70543376
No adverse event 27.84 11.09 282 384767 31871 70511524
Gastritis erosive 27.79 11.09 10 385039 10085 70533310
Red cell distribution width decreased 27.72 11.09 39 385010 1590 70541805
Medication error 27.59 11.09 188 384861 56724 70486671
BK virus infection 27.57 11.09 5 385044 7984 70535411
Visual acuity reduced 27.53 11.09 70 384979 27860 70515535
Myocarditis 27.50 11.09 37 385012 18756 70524639
Fracture delayed union 27.47 11.09 44 385005 2015 70541380
Large intestine polyp 27.40 11.09 14 385035 11462 70531933
Mycobacterium tuberculosis complex test positive 27.30 11.09 47 385002 2286 70541109
Ankle arthroplasty 27.28 11.09 33 385016 1157 70542238
Memory impairment 27.18 11.09 347 384702 92294 70451101
Pneumonia fungal 27.16 11.09 10 385039 9943 70533452
Taste disorder 27.02 11.09 14 385035 11371 70532024
Eyelid oedema 26.88 11.09 18 385031 12709 70530686
Mean platelet volume decreased 26.78 11.09 46 385003 2233 70541162
Gastric ulcer 26.69 11.09 86 384963 31704 70511691
Cholecystitis acute 26.66 11.09 16 385033 11978 70531417
Stress at work 26.65 11.09 31 385018 1042 70542353
Neuropsychiatric lupus 26.64 11.09 15 385034 169 70543226
Amylase increased 26.63 11.09 11 385038 10197 70533198
Diplopia 26.63 11.09 72 384977 28075 70515320
Eosinophil count increased 26.58 11.09 26 385023 15196 70528199
Hospice care 26.52 11.09 6 385043 8199 70535196
Incoherent 26.49 11.09 4 385045 7302 70536093
Type 2 lepra reaction 26.45 11.09 20 385029 383 70543012
Drug specific antibody present 26.44 11.09 80 384969 5678 70537717
Body tinea 26.39 11.09 35 385014 1348 70542047
Drug level above therapeutic 26.39 11.09 5 385044 7737 70535658
Antiphospholipid syndrome 26.35 11.09 39 385010 1666 70541729
Ketoacidosis 26.31 11.09 4 385045 7265 70536130
Blood albumin decreased 26.30 11.09 50 384999 22077 70521318
Respiratory depression 26.24 11.09 60 384989 24771 70518624
Catatonia 26.18 11.09 6 385043 8127 70535268
Coma scale abnormal 26.10 11.09 6 385043 8110 70535285
Blood loss anaemia 25.99 11.09 24 385025 14417 70528978
Hepatic cytolysis 25.90 11.09 40 385009 19152 70524243
Carpal tunnel syndrome 25.89 11.09 170 384879 16887 70526508
Left ventricular dysfunction 25.63 11.09 36 385013 17921 70525474
Thirst 25.60 11.09 25 385024 14624 70528771
Infection reactivation 25.43 11.09 46 385003 2327 70541068
Klebsiella infection 25.43 11.09 24 385025 14268 70529127
Proctalgia 25.41 11.09 7 385042 8376 70535019
Body temperature increased 25.32 11.09 329 384720 39505 70503890
Anal abscess 25.29 11.09 7 385042 8351 70535044
Vasculitic rash 25.28 11.09 42 385007 1984 70541411
Abnormal dreams 25.22 11.09 13 385036 10590 70532805
Fistula 24.92 11.09 14 385035 10867 70532528
Soft tissue disorder 24.90 11.09 56 384993 3318 70540077
Nervousness 24.88 11.09 86 384963 31034 70512361
Fear 24.76 11.09 47 385002 20764 70522631
Adjustment disorder with depressed mood 24.63 11.09 64 384985 4159 70539236
Eyelid ptosis 24.61 11.09 12 385037 10090 70533305
Urosepsis 24.40 11.09 59 384990 23890 70519505
Hypoxic-ischaemic encephalopathy 24.32 11.09 5 385044 7303 70536092
Intestinal ischaemia 24.25 11.09 18 385031 12046 70531349
Ageusia 24.13 11.09 27 385022 14835 70528560
Atrioventricular block first degree 24.00 11.09 17 385032 11656 70531739
Blood phosphorus increased 23.88 11.09 4 385045 6766 70536629
Smear cervix abnormal 23.86 11.09 45 385004 2351 70541044
Ocular toxicity 23.80 11.09 26 385023 815 70542580
Walking aid user 23.71 11.09 96 384953 7885 70535510
Disease susceptibility 23.66 11.09 17 385032 300 70543095
Toxic skin eruption 23.58 11.09 46 385003 20116 70523279
Hepatocellular carcinoma 23.57 11.09 13 385036 10195 70533200
Nodular regenerative hyperplasia 23.57 11.09 32 385017 1261 70542134
Shoulder operation 23.54 11.09 45 385004 2375 70541020
Device use error 23.52 11.09 4 385045 6692 70536703
Erythema 23.49 11.09 866 384183 198697 70344698
Palindromic rheumatism 23.49 11.09 19 385030 403 70542992
Cerebral atrophy 23.45 11.09 6 385043 7541 70535854
Scleritis 23.33 11.09 57 384992 3565 70539830
Femoral neck fracture 23.31 11.09 10 385039 9063 70534332
Pulmonary haemorrhage 23.13 11.09 24 385025 13649 70529746
Haemorrhoids 23.06 11.09 67 384982 25521 70517874
Dermatitis atopic 23.03 11.09 10 385039 8997 70534398
Hepatic lesion 23.00 11.09 3 385046 6114 70537281
Cerebral ischaemia 22.99 11.09 14 385035 10398 70532997
Joint ankylosis 22.98 11.09 35 385014 1534 70541861
Drug reaction with eosinophilia and systemic symptoms 22.80 11.09 203 384846 57810 70485585
Cytomegalovirus viraemia 22.76 11.09 18 385031 11667 70531728
Product substitution issue 22.75 11.09 41 385008 18472 70524923
Limb operation 22.69 11.09 51 384998 3021 70540374
Tongue disorder 22.67 11.09 136 384913 13091 70530304
Posterior reversible encephalopathy syndrome 22.65 11.09 63 384986 24339 70519056
Retinal degeneration 22.65 11.09 30 385019 1154 70542241
Adenovirus infection 22.60 11.09 7 385042 7761 70535634
Micturition urgency 22.59 11.09 17 385032 11297 70532098
Amenorrhoea 22.53 11.09 5 385044 6925 70536470
Large intestine perforation 22.51 11.09 23 385026 13172 70530223
Cardiac failure chronic 22.41 11.09 14 385035 10255 70533140
Erysipelas 22.39 11.09 13 385036 9911 70533484
Polydipsia 22.36 11.09 3 385046 5985 70537410
Refusal of treatment by patient 22.30 11.09 9 385040 8461 70534934
Enteritis 22.30 11.09 22 385027 12809 70530586
Hypotonia 22.22 11.09 19 385030 11846 70531549
Blood potassium increased 22.20 11.09 75 384974 27251 70516144
Metabolic disorder 22.08 11.09 8 385041 8032 70535363
Hypoacusis 22.05 11.09 75 384974 27194 70516201
Paraesthesia oral 21.91 11.09 31 385018 15386 70528009
Electrocardiogram ST segment elevation 21.86 11.09 7 385042 7597 70535798
Drug level below therapeutic 21.81 11.09 10 385039 8713 70534682
Hyperventilation 21.78 11.09 6 385043 7180 70536215
Oxygen saturation decreased 21.69 11.09 474 384575 115955 70427440
Frequent bowel movements 21.64 11.09 52 384997 21101 70522294
Drug screen positive 21.63 11.09 3 385046 5837 70537558
Cardiomegaly 21.60 11.09 65 384984 24480 70518915
Cholecystitis chronic 21.56 11.09 12 385037 9364 70534031
Rash pruritic 21.46 11.09 470 384579 62521 70480874
Hydronephrosis 21.31 11.09 31 385018 15211 70528184
Hepatomegaly 21.26 11.09 39 385010 17453 70525942
Systemic infection 21.25 11.09 5 385044 6652 70536743
Double stranded DNA antibody positive 21.18 11.09 18 385031 410 70542985
Hyperbilirubinaemia 21.15 11.09 58 384991 22510 70520885
C-reactive protein decreased 21.08 11.09 43 385006 2381 70541014
Pathological fracture 21.00 11.09 13 385036 9570 70533825
Gastric ulcer haemorrhage 20.93 11.09 10 385039 8508 70534887
Hypoventilation 20.90 11.09 5 385044 6577 70536818
Hepatitis fulminant 20.90 11.09 5 385044 6576 70536819
Anaphylactic shock 20.80 11.09 98 384951 32392 70511003
Autoimmune haemolytic anaemia 20.78 11.09 8 385041 7738 70535657
Renal tubular disorder 20.71 11.09 4 385045 6106 70537289
Decubitus ulcer 20.70 11.09 28 385021 14163 70529232
Middle lobe syndrome 20.69 11.09 8 385041 34 70543361
Atrioventricular block 20.65 11.09 23 385026 12665 70530730
Heart rate abnormal 20.65 11.09 3 385046 5636 70537759
Apnoea 20.62 11.09 17 385032 10792 70532603
Influenza like illness 20.56 11.09 241 384808 65090 70478305
Photosensitivity reaction 20.44 11.09 177 384872 19163 70524232
Blood pressure systolic increased 20.40 11.09 430 384619 56829 70486566
Rotator cuff repair 20.30 11.09 34 385015 1617 70541778
Systemic inflammatory response syndrome 20.25 11.09 17 385032 10695 70532700
Trigger finger 20.24 11.09 55 384994 3672 70539723
Personality disorder 20.20 11.09 3 385046 5545 70537850
COVID-19 pneumonia 20.15 11.09 195 384854 21774 70521621
Hypercapnia 20.13 11.09 10 385039 8319 70535076
Colon cancer 20.10 11.09 29 385020 14277 70529118
Staphylococcal sepsis 20.09 11.09 26 385023 13401 70529994
Diabetic eye disease 20.04 11.09 12 385037 153 70543242
Gingivitis 19.88 11.09 10 385039 8260 70535135
Hypernatraemia 19.84 11.09 24 385025 12737 70530658
Androgenetic alopecia 19.84 11.09 12 385037 156 70543239
Extradural abscess 19.82 11.09 29 385020 1226 70542169
Placenta accreta 19.78 11.09 13 385036 197 70543198
Precancerous cells present 19.77 11.09 27 385022 1070 70542325
Tricuspid valve incompetence 19.69 11.09 42 385007 17775 70525620
Disseminated strongyloidiasis 19.64 11.09 12 385037 159 70543236
Cachexia 19.60 11.09 15 385034 9885 70533510
Sensory disturbance 19.47 11.09 28 385021 13804 70529591
Incorrect product administration duration 19.47 11.09 18 385031 10806 70532589
Stress cardiomyopathy 19.46 11.09 15 385034 9847 70533548
Generalised oedema 19.45 11.09 57 384992 21651 70521744
Obsessive-compulsive disorder 19.33 11.09 3 385046 5367 70538028
Eye pruritus 19.32 11.09 31 385018 14616 70528779
Kidney duplex 19.14 11.09 6 385043 11 70543384
Spinal meningioma benign 19.13 11.09 10 385039 96 70543299
Arthritis bacterial 19.12 11.09 92 384957 8141 70535254
Intervertebral disc compression 19.10 11.09 26 385023 1027 70542368
Infective tenosynovitis 19.10 11.09 16 385033 357 70543038
Exposure to toxic agent 19.10 11.09 5 385044 6189 70537206
Secretion discharge 19.08 11.09 128 384921 12805 70530590
Peripheral ischaemia 19.03 11.09 12 385037 8746 70534649
Retinal haemorrhage 19.02 11.09 9 385040 7701 70535694
Forced expiratory volume decreased 18.89 11.09 8 385041 7306 70536089
Hiccups 18.86 11.09 13 385036 9039 70534356
Rheumatic disorder 18.85 11.09 41 385008 2375 70541020
Wrong product administered 18.76 11.09 11 385038 8340 70535055
Bacterial sepsis 18.76 11.09 9 385040 7638 70535757
Intermenstrual bleeding 18.75 11.09 3 385046 5247 70538148
Nystagmus 18.75 11.09 14 385035 9341 70534054
Gastrointestinal perforation 18.67 11.09 4 385045 5677 70537718
Tendonitis 18.66 11.09 193 384856 21929 70521466
Cerebellar syndrome 18.66 11.09 3 385046 5228 70538167
PaO2/FiO2 ratio decreased 18.63 11.09 7 385042 27 70543368
Nephropathy toxic 18.56 11.09 46 385003 18468 70524927
Bradyphrenia 18.54 11.09 16 385033 9930 70533465
Oral disorder 18.53 11.09 99 384950 9130 70534265
External auditory canal atresia 18.48 11.09 6 385043 13 70543382
Peripheral venous disease 18.39 11.09 110 384939 10577 70532818
Skin toxicity 18.39 11.09 8 385041 7190 70536205
Thrombosis in device 18.38 11.09 3 385046 5172 70538223
Viral vasculitis 18.38 11.09 11 385038 140 70543255
Thinking abnormal 18.38 11.09 23 385026 12028 70531367
Deep vein thrombosis postoperative 18.37 11.09 52 384997 3555 70539840
Haemoglobin increased 18.36 11.09 4 385045 5611 70537784
Hypovolaemic shock 18.36 11.09 19 385030 10818 70532577
Coronary artery occlusion 18.32 11.09 31 385018 14314 70529081
Macular oedema 18.32 11.09 3 385046 5159 70538236
Occult blood positive 18.27 11.09 6 385043 6407 70536988
Retinal coloboma 18.18 11.09 6 385043 14 70543381
Iris coloboma 18.18 11.09 6 385043 14 70543381
Anticoagulation drug level increased 18.12 11.09 21 385028 703 70542692
Central nervous system lupus 18.06 11.09 16 385033 386 70543009
Brain natriuretic peptide increased 18.02 11.09 11 385038 8160 70535235
Blood thyroid stimulating hormone increased 17.90 11.09 12 385037 8467 70534928
Blood uric acid increased 17.86 11.09 14 385035 9115 70534280
Coronary artery bypass 17.84 11.09 5 385044 5915 70537480
Infected seroma 17.81 11.09 9 385040 80 70543315
Azotaemia 17.72 11.09 10 385039 7743 70535652
Muscle haemorrhage 17.67 11.09 5 385044 5879 70537516
Squamous cell carcinoma of skin 17.63 11.09 26 385023 12686 70530709
Cranial nerve injury 17.62 11.09 6 385043 16 70543379
Infectious crystalline keratopathy 17.62 11.09 6 385043 16 70543379
Natural killer-cell leukaemia 17.58 11.09 10 385039 115 70543280
Paradoxical drug reaction 17.56 11.09 7 385042 6629 70536766
Duodenitis 17.55 11.09 8 385041 6994 70536401
Adenoiditis 17.53 11.09 7 385042 33 70543362
Interstitial lung disease 17.52 11.09 715 384334 103970 70439425
Neck surgery 17.45 11.09 32 385017 1636 70541759
Device failure 17.45 11.09 5 385044 5830 70537565
Transaminases increased 17.41 11.09 167 384882 46851 70496544
Pulse absent 17.40 11.09 15 385034 9315 70534080
Blood chloride increased 17.31 11.09 3 385046 4950 70538445
Laryngitis 17.26 11.09 130 384919 13501 70529894
Loss of employment 17.24 11.09 38 385011 2221 70541174
Hiatus hernia 17.17 11.09 58 384991 21076 70522319
Faeces soft 17.15 11.09 8 385041 6902 70536493
Dermatitis acneiform 17.15 11.09 14 385035 8931 70534464
Breast cancer stage II 17.10 11.09 4 385045 5342 70538053
Symptom masked 17.09 11.09 27 385022 1222 70542173
Snoring 17.07 11.09 3 385046 4901 70538494
Cyst 17.07 11.09 123 384926 12596 70530799
Peripheral coldness 17.03 11.09 33 385016 14467 70528928
Clostridial infection 17.02 11.09 4 385045 5325 70538070
Sudden cardiac death 16.98 11.09 3 385046 4882 70538513
Rash macular 16.97 11.09 76 384973 25468 70517927
Respiration abnormal 16.96 11.09 8 385041 6856 70536539
Blood pressure fluctuation 16.94 11.09 430 384619 58582 70484813
Benign prostatic hyperplasia 16.92 11.09 19 385030 10424 70532971
Human herpesvirus 6 infection 16.86 11.09 3 385046 4856 70538539
Escherichia sepsis 16.85 11.09 10 385039 7533 70535862
Bronchopleural fistula 16.81 11.09 19 385030 619 70542776
Aortic arteriosclerosis 16.80 11.09 11 385038 7858 70535537
Allergy to vaccine 16.78 11.09 11 385038 166 70543229
Central nervous system lesion 16.76 11.09 26 385023 12427 70530968
Back pain 16.75 11.09 1256 383793 269896 70273499
Hypomania 16.74 11.09 6 385043 6066 70537329
Blood chloride decreased 16.72 11.09 11 385038 7839 70535556
Somnambulism 16.69 11.09 4 385045 5256 70538139
Electrocardiogram abnormal 16.68 11.09 34 385015 14630 70528765
Bradykinesia 16.68 11.09 10 385039 7492 70535903
Lacrimation increased 16.59 11.09 54 384995 19845 70523550
Expired product administered 16.59 11.09 7 385042 6406 70536989
Product monitoring error 16.58 11.09 8 385041 6768 70536627
Rash erythematous 16.58 11.09 190 384859 51528 70491867
Injection site mass 16.55 11.09 48 385001 18295 70525100
Tendon disorder 16.53 11.09 75 384974 6476 70536919
Hip fracture 16.52 11.09 88 384961 28175 70515220
Congestive cardiomyopathy 16.51 11.09 21 385028 10905 70532490
Gingival pain 16.50 11.09 8 385041 6749 70536646
Renal cancer 16.49 11.09 24 385025 11772 70531623
Atelectasis 16.47 11.09 91 384958 28871 70514524
Internal haemorrhage 16.45 11.09 12 385037 8104 70535291
Vaginal haemorrhage 16.44 11.09 56 384993 20296 70523099
Facial paralysis 16.34 11.09 54 384995 19754 70523641
Depressive symptom 16.33 11.09 4 385045 5177 70538218
Eosinophilia 16.33 11.09 140 384909 40179 70503216
Brain death 16.31 11.09 4 385045 5174 70538221
Therapy change 16.30 11.09 8 385041 6701 70536694
Dizziness postural 16.29 11.09 19 385030 10249 70533146
Renal disorder 16.29 11.09 130 384919 37879 70505516
Intrauterine infection 16.23 11.09 8 385041 67 70543328
Epigastric discomfort 16.20 11.09 80 384969 7153 70536242
Fibrin D dimer increased 16.20 11.09 10 385039 7373 70536022
Bacterial test positive 16.17 11.09 9 385040 7022 70536373
Initial insomnia 16.14 11.09 7 385042 6302 70537093
Staphylococcal bacteraemia 16.03 11.09 22 385027 11060 70532335
Cytomegalovirus test positive 15.96 11.09 5 385044 5503 70537892
Endophthalmitis 15.90 11.09 7 385042 6248 70537147
Parainfluenzae virus infection 15.86 11.09 4 385045 5076 70538319
Brain herniation 15.86 11.09 9 385040 6947 70536448
Skin discolouration 15.84 11.09 128 384921 37197 70506198
Cardiac tamponade 15.81 11.09 14 385035 8581 70534814
Diffuse idiopathic skeletal hyperostosis 15.76 11.09 7 385042 45 70543350
Exercise tolerance decreased 15.70 11.09 13 385036 8235 70535160
Mean cell volume decreased 15.68 11.09 56 384993 4334 70539061
Petit mal epilepsy 15.67 11.09 5 385044 5439 70537956
Menopausal symptoms 15.61 11.09 31 385018 1683 70541712
Urticaria 15.56 11.09 1056 383993 161993 70381402
Hepatitis cholestatic 15.56 11.09 28 385021 12622 70530773
Chronic lymphocytic leukaemia 15.53 11.09 6 385043 5792 70537603
Anaphylactoid reaction 15.52 11.09 4 385045 5003 70538392
Cardiovascular disorder 15.50 11.09 43 385006 16627 70526768
Rash papular 15.47 11.09 49 385000 18161 70525234
Muscle tightness 15.41 11.09 25 385024 11737 70531658
Procedural complication 15.38 11.09 11 385038 7503 70535892
Treatment noncompliance 15.37 11.09 170 384879 46404 70496991
Histoplasmosis 15.36 11.09 35 385014 2092 70541303
Device breakage 15.34 11.09 17 385032 9381 70534014
Complement factor C4 decreased 15.33 11.09 13 385036 295 70543100
Hypoaesthesia oral 15.33 11.09 27 385022 12273 70531122
Cutaneous sarcoidosis 15.31 11.09 16 385033 476 70542919
Herpes zoster reactivation 15.30 11.09 10 385039 150 70543245
Sensory loss 15.22 11.09 24 385025 11395 70532000
Dermatitis exfoliative 15.21 11.09 21 385028 10530 70532865
External ear disorder 15.11 11.09 8 385041 79 70543316
Complement factor C3 decreased 15.10 11.09 14 385035 359 70543036
Lacunar infarction 15.08 11.09 6 385043 5690 70537705
Compartment syndrome 15.07 11.09 3 385046 4483 70538912
Atrial flutter 15.05 11.09 58 384991 20269 70523126
Eosinophilic pneumonia 15.05 11.09 4 385045 4901 70538494
Prescribed overdose 15.04 11.09 219 384830 26962 70516433
Blood pH decreased 15.02 11.09 3 385046 4473 70538922
Localised oedema 15.01 11.09 11 385038 7410 70535985
Apathy 14.97 11.09 26 385023 11882 70531513
Ventricular tachycardia 14.96 11.09 126 384923 36297 70507098
Pregnancy 14.94 11.09 196 384853 23585 70519810
Thyroid disorder 14.93 11.09 120 384929 12712 70530683
Fundoscopy abnormal 14.91 11.09 7 385042 52 70543343
Cerebral haematoma 14.84 11.09 11 385038 7367 70536028
Hallucinations, mixed 14.84 11.09 8 385041 6354 70537041
Aplasia pure red cell 14.82 11.09 11 385038 7363 70536032
Lung adenocarcinoma 14.79 11.09 12 385037 7678 70535717
International normalised ratio abnormal 14.79 11.09 5 385044 5242 70538153
Product administered to patient of inappropriate age 14.76 11.09 4 385045 4839 70538556
Osteosclerosis 14.75 11.09 49 385000 3656 70539739
Gangrene 14.73 11.09 14 385035 8295 70535100
Speech sound disorder 14.69 11.09 7 385042 54 70543341
Larynx irritation 14.68 11.09 9 385040 120 70543275
Hereditary motor and sensory neuropathy 14.68 11.09 9 385040 120 70543275
Performance status decreased 14.67 11.09 6 385043 5595 70537800
Back disorder 14.67 11.09 103 384946 10461 70532934
Neutrophil/lymphocyte ratio increased 14.66 11.09 4 385045 3 70543392
Autoimmune disorder 14.64 11.09 89 384960 8607 70534788
Clinical trial participant 14.62 11.09 9 385040 121 70543274
Venous thrombosis 14.60 11.09 9 385040 6640 70536755
DNA antibody 14.58 11.09 6 385043 31 70543364
Lupus enteritis 14.58 11.09 7 385042 55 70543340
Overwork 14.58 11.09 7 385042 55 70543340
Oral lichen planus 14.56 11.09 19 385030 720 70542675
Escherichia infection 14.55 11.09 43 385006 16288 70527107
Embolic stroke 14.49 11.09 11 385038 7278 70536117
Blood culture positive 14.47 11.09 13 385036 7913 70535482
Lymphocyte percentage decreased 14.47 11.09 4 385045 4775 70538620
Gastrointestinal toxicity 14.46 11.09 71 384978 6334 70537061
Eye pain 14.45 11.09 117 384932 33985 70509410
Extra dose administered 14.44 11.09 11 385038 7266 70536129
Ossicle disorder 14.43 11.09 6 385043 32 70543363
Connective tissue disorder 14.41 11.09 24 385025 1136 70542259
Pseudomonal sepsis 14.39 11.09 6 385043 5531 70537864
Coronary arterial stent insertion 14.33 11.09 7 385042 5880 70537515
Pleuritic pain 14.32 11.09 90 384959 8807 70534588
Antinuclear antibody 14.31 11.09 15 385034 448 70542947
Erythematotelangiectatic rosacea 14.26 11.09 5 385044 15 70543380
Dactylitis 14.23 11.09 35 385014 2198 70541197
Gastrointestinal necrosis 14.21 11.09 5 385044 5113 70538282
Andersen-Tawil syndrome 14.14 11.09 4 385045 4 70543391
Haematocrit decreased 14.12 11.09 222 384827 57036 70486359
Hyperphosphataemia 14.08 11.09 3 385046 4273 70539122
Liver transplant 14.03 11.09 3 385046 4263 70539132
Sinus node dysfunction 14.02 11.09 11 385038 7158 70536237
Skin irritation 14.01 11.09 20 385029 9889 70533506
Joint space narrowing 14 11.09 14 385035 395 70543000
Blood disorder 13.95 11.09 11 385038 7141 70536254
Skin haemorrhage 13.95 11.09 21 385028 10159 70533236
Rhinitis allergic 13.91 11.09 18 385031 9277 70534118
Vaginal haematoma 13.89 11.09 9 385040 133 70543262
Blood calcium increased 13.89 11.09 17 385032 8976 70534419
Heavy menstrual bleeding 13.88 11.09 30 385019 12635 70530760
Carcinoid tumour pulmonary 13.87 11.09 13 385036 338 70543057
Infusion site pain 13.86 11.09 26 385023 11538 70531857
Eye movement disorder 13.83 11.09 12 385037 7428 70535967
Atrioventricular block second degree 13.77 11.09 10 385039 6768 70536627
Venoocclusive disease 13.72 11.09 3 385046 4197 70539198
Human anti-human antibody test 13.69 11.09 14 385035 406 70542989
Paronychia 13.65 11.09 11 385038 7063 70536332
Skin abrasion 13.64 11.09 29 385020 12288 70531107
Injection site haemorrhage 13.56 11.09 82 384967 25445 70517950
Iodine allergy 13.52 11.09 16 385033 548 70542847
Intracranial pressure increased 13.51 11.09 12 385037 7344 70536051
Infection susceptibility increased 13.50 11.09 41 385008 2916 70540479
Renal cyst 13.50 11.09 33 385016 13312 70530083
Allergy to chemicals 13.49 11.09 32 385017 1964 70541431
Vasculitis 13.48 11.09 164 384885 19394 70524001
Pneumonia cytomegaloviral 13.47 11.09 4 385045 4557 70538838
Blood bicarbonate decreased 13.43 11.09 5 385044 4936 70538459
Haemorrhoidal haemorrhage 13.42 11.09 8 385041 6011 70537384
Ganglioneuroma 13.38 11.09 9 385040 142 70543253
Disability assessment scale score increased 13.38 11.09 41 385008 2930 70540465
Restless legs syndrome 13.37 11.09 53 384996 18375 70525020
Carotid artery stenosis 13.33 11.09 15 385034 8221 70535174
Brain neoplasm 13.31 11.09 6 385043 5280 70538115
Immobile 13.27 11.09 70 384979 6424 70536971
Persecutory delusion 13.27 11.09 4 385045 4513 70538882
Swollen joint count 13.27 11.09 21 385028 952 70542443
Gastroenteritis 13.26 11.09 107 384942 31106 70512289
Splenomegaly 13.24 11.09 55 384994 18815 70524580
Transient hypogammaglobulinaemia of infancy 13.20 11.09 6 385043 41 70543354
Mitral valve incompetence 13.10 11.09 88 384961 26640 70516755
Respiratory alkalosis 13.06 11.09 3 385046 4058 70539337
Mean cell haemoglobin decreased 13.06 11.09 60 384989 5208 70538187
Urine abnormality 12.99 11.09 14 385035 7824 70535571
Papulopustular rosacea 12.98 11.09 5 385044 21 70543374
Diverticulum 12.97 11.09 35 385014 13658 70529737
Rhinitis 12.95 11.09 27 385022 11520 70531875
Temperature regulation disorder 12.94 11.09 4 385045 4440 70538955
Eczema 12.93 11.09 119 384930 33662 70509733
Back injury 12.92 11.09 87 384962 8715 70534680
Product label confusion 12.92 11.09 19 385030 807 70542588
Knee deformity 12.87 11.09 21 385028 977 70542418
Affective disorder 12.80 11.09 13 385036 7466 70535929
Localised infection 12.80 11.09 252 384797 32906 70510489
Hepatotoxicity 12.77 11.09 321 384728 43665 70499730
Humerus fracture 12.77 11.09 16 385033 8362 70535033
Oligoarthritis 12.76 11.09 15 385034 510 70542885
Visual field defect 12.75 11.09 84 384965 8354 70535041
Contraindication to medical treatment 12.74 11.09 23 385026 1162 70542233
Mass 12.67 11.09 138 384911 15888 70527507
Lupus pancreatitis 12.66 11.09 3 385046 0 70543395
Hyperreflexia 12.66 11.09 13 385036 7429 70535966
Portal hypertension 12.65 11.09 10 385039 6482 70536913
Subdural haemorrhage 12.63 11.09 7 385042 5474 70537921
Productive cough 12.62 11.09 326 384723 78011 70465384
Tender joint count increased 12.61 11.09 9 385040 157 70543238
Areflexia 12.61 11.09 6 385043 5116 70538279
Urine analysis abnormal 12.61 11.09 9 385040 6145 70537250
Vascular device infection 12.59 11.09 15 385034 8015 70535380
Hepatorenal syndrome 12.58 11.09 3 385046 3954 70539441
Head discomfort 12.56 11.09 33 385016 12990 70530405
Enterococcal infection 12.55 11.09 39 385010 14543 70528852
Hyperlipidaemia 12.49 11.09 77 384972 23786 70519609
Throat tightness 12.45 11.09 82 384967 24940 70518455
Hyperlactacidaemia 12.39 11.09 6 385043 5066 70538329
Hypertensive heart disease 12.39 11.09 3 385046 3913 70539482
Upper limb fracture 12.38 11.09 138 384911 15981 70527414
Varices oesophageal 12.36 11.09 7 385042 5410 70537985
Multiple-drug resistance 12.34 11.09 13 385036 7342 70536053
Procedural pain 12.32 11.09 53 384996 17956 70525439
Facial paresis 12.31 11.09 6 385043 5047 70538348
Endocarditis 12.27 11.09 22 385027 9932 70533463
Food allergy 12.25 11.09 17 385032 8507 70534888
Drug dependence 12.25 11.09 277 384772 37044 70506351
Laryngeal pain 12.24 11.09 8 385041 5720 70537675
Oral discomfort 12.20 11.09 86 384963 8745 70534650
Social avoidant behaviour 12.17 11.09 5 385044 4651 70538744
Foetal growth restriction 12.15 11.09 30 385019 1889 70541506
Sneezing 12.14 11.09 49 385000 16902 70526493
Pericardial haemorrhage 12.14 11.09 4 385045 4264 70539131
Meningitis streptococcal 12.14 11.09 9 385040 167 70543228
Blood creatine increased 12.08 11.09 18 385031 8746 70534649
Rheumatoid factor 12.07 11.09 8 385041 123 70543272
Alcohol use 12.05 11.09 5 385044 4622 70538773
Culture urine positive 12.01 11.09 4 385045 4233 70539162
Affect lability 12.00 11.09 23 385026 10123 70533272
Infected varicose vein 11.97 11.09 5 385044 27 70543368
Spinal X-ray abnormal 11.97 11.09 5 385044 27 70543368
Amnesia 11.95 11.09 205 384844 51950 70491445
Metastases to peritoneum 11.93 11.09 3 385046 3816 70539579
Osteonecrosis 11.92 11.09 101 384948 29059 70514336
Infusion site erythema 11.90 11.09 14 385035 7521 70535874
Osteomyelitis bacterial 11.89 11.09 14 385035 477 70542918
Gonorrhoea 11.87 11.09 9 385040 173 70543222
Neoplasm 11.86 11.09 15 385034 7809 70535586
Pulmonary mass 11.85 11.09 203 384846 25830 70517565
Aspergillosis oral 11.81 11.09 6 385043 54 70543341
Abdominal pain upper 11.78 11.09 1212 383837 192390 70351005
Laryngeal oedema 11.75 11.09 14 385035 7481 70535914
Embolism 11.71 11.09 34 385015 12954 70530441
Nocturia 11.71 11.09 31 385018 12173 70531222
Blood pressure inadequately controlled 11.69 11.09 8 385041 5584 70537811
Facial bones fracture 11.69 11.09 5 385044 4539 70538856
Neutrophil percentage increased 11.68 11.09 5 385044 4537 70538858
Arthritis salmonella 11.66 11.09 4 385045 11 70543384
Biopsy heart abnormal 11.66 11.09 4 385045 11 70543384
Eructation 11.65 11.09 22 385027 9738 70533657
Myositis 11.64 11.09 52 384997 17437 70525958
Bursitis infective 11.63 11.09 23 385026 1245 70542150
Granulomatous dermatitis 11.62 11.09 12 385037 352 70543043
Blindness 11.62 11.09 76 384973 23151 70520244
Episcleritis 11.60 11.09 20 385029 974 70542421
Arterial occlusive disease 11.58 11.09 15 385034 7727 70535668
Disease complication 11.57 11.09 5 385044 4512 70538883
Wound dehiscence 11.55 11.09 10 385039 6198 70537197
Skin papilloma 11.55 11.09 59 384990 5347 70538048
Lung consolidation 11.51 11.09 17 385032 8289 70535106
Diastolic dysfunction 11.49 11.09 21 385028 9412 70533983
Diabetic neuropathy 11.44 11.09 9 385040 5849 70537546
Ischaemic cardiomyopathy 11.43 11.09 13 385036 7091 70536304
Retinal injury 11.43 11.09 11 385038 296 70543099
Mean cell haemoglobin concentration decreased 11.41 11.09 4 385045 4099 70539296
Acute vestibular syndrome 11.41 11.09 5 385044 31 70543364
Child abuse 11.38 11.09 12 385037 361 70543034
Haematocrit increased 11.30 11.09 3 385046 3679 70539716
Protein total decreased 11.27 11.09 17 385032 8219 70535176
Respiratory syncytial virus infection 11.27 11.09 15 385034 7640 70535755
Self-medication 11.25 11.09 5 385044 4438 70538957
Cardiac operation 11.24 11.09 5 385044 4434 70538961
Abdominal wall haematoma 11.20 11.09 5 385044 4425 70538970
Ventricular hypokinesia 11.19 11.09 17 385032 8195 70535200
Pruritus allergic 11.19 11.09 21 385028 1093 70542302
Oedema 11.19 11.09 454 384595 103127 70440268
Nerve block 11.19 11.09 15 385034 584 70542811
Viral infection 11.18 11.09 144 384905 38247 70505148
Behaviour disorder 11.18 11.09 8 385041 5456 70537939
Pseudomonas infection 11.18 11.09 59 384990 18935 70524460
Normochromic normocytic anaemia 11.14 11.09 13 385036 7010 70536385
Phlebitis 11.13 11.09 17 385032 8177 70535218
Cardiopulmonary failure 11.13 11.09 11 385038 6399 70536996
Hypergammaglobulinaemia 11.12 11.09 16 385033 666 70542729
Intestinal perforation 11.11 11.09 47 385002 15997 70527398

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P01BA02 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Aminoquinolines
FDA EPC N0000175482 Antimalarial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:35842 anti-rheumatic drugs
CHEBI has role CHEBI:38068 antimalarials
CHEBI has role CHEBI:50177 dermatologic agent
CHEBI has role CHEBI:149553 anticoronaviral drug
FDA EPC N0000175713 Antirheumatic Agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ovale malaria indication 19341001 DOID:12919
Vivax malaria indication 27052006 DOID:12978
Quartan malaria indication 27618009 DOID:14324
Systemic lupus erythematosus indication 55464009 DOID:9074
Falciparum malaria indication 62676009 DOID:14067
Rheumatoid arthritis indication 69896004 DOID:7148
Discoid lupus erythematosus indication 200938002
Plasmodium Malariae Malaria Prevention indication
Plasmodium Ovale Malaria Prevention indication
Malaria Prevention indication
Plasmodium Falciparum Malaria Prevention indication
Vasculitis of the skin off-label use 53312001
Porphyria cutanea tarda off-label use 61860000 DOID:3132
Q fever endocarditis off-label use 95890006
Coronavirus infection off-label use 186747009
Polymorphic light eruption off-label use 238525001
Juvenile rheumatoid arthritis off-label use 410795001
Hypercalcemia associated with Sarcoidosis off-label use
Alcoholism contraindication 7200002
Psoriasis contraindication 9014002 DOID:8893
Visual field defect contraindication 12184005
Retinal disorder contraindication 29555009 DOID:5679
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Neutropenic disorder contraindication 303011007 DOID:1227
Disorder of macula of retina contraindication 312999006
Disorder of eye contraindication 371405004 DOID:5614
Visual impairment contraindication 397540003
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.51 Basic
pKa2 7.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Toll-like receptor 7 Membrane receptor ANTAGONIST IC50 5.56 IUPHAR CHEMBL
Toll-like receptor 9 Membrane receptor ANTAGONIST IC50 7.10 IUPHAR CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 4.14 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 4.81 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 5.98 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 5.32 CHEMBL
Muscarinic acetylcholine receptor M4 GPCR Ki 5.26 CHEMBL
Muscarinic acetylcholine receptor M5 GPCR Ki 4.70 CHEMBL
Alpha-2C adrenergic receptor GPCR Ki 4.80 CHEMBL
Hemoglobin subunit alpha Secreted WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 5.63 DRUG MATRIX
Transmembrane protein 97 Enzyme Ki 6 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.19 CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.90 CHEMBL
Genome polyprotein Unclassified Ki 4.04 CHEMBL

External reference:

IDSource
4019780 VUID
N0000147871 NUI
D02114 KEGG_DRUG
747-36-4 SECONDARY_CAS_RN
4018253 VANDF
4019780 VANDF
C0020336 UMLSCUI
CHEBI:5801 CHEBI
CHEMBL1535 ChEMBL_ID
DB01611 DRUGBANK_ID
CHEMBL1690 ChEMBL_ID
D006886 MESH_DESCRIPTOR_UI
3652 PUBCHEM_CID
7198 IUPHAR_LIGAND_ID
796 INN_ID
4QWG6N8QKH UNII
153972 RXNORM
15082 MMSL
1645 MMSL
4852 MMSL
d00817 MMSL
002949 NDDF
004906 NDDF
13502005 SNOMEDCT_US
373540008 SNOMEDCT_US
83490000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0093-2401 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0093-2401 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0373 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0373 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0591-3041 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8374 TABLET, FILM COATED 200 mg ORAL ANDA 10 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8401 TABLET 200 mg ORAL ANDA 30 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8401 TABLET 200 mg ORAL ANDA 30 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0781-5994 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6884 TABLET, FILM COATED 200 mg ORAL ANDA 14 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7046 TABLET 200 mg ORAL ANDA 17 sections
HYDROXYCHLOROQUINE SULFATE HUMAN PRESCRIPTION DRUG LABEL 1 0904-7046 TABLET 200 mg ORAL ANDA 17 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 16571-687 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 16571-687 TABLET, FILM COATED 200 mg ORAL ANDA 27 sections
Hydroxychloroquine sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-110 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-753 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16714-753 TABLET, FILM COATED 200 mg ORAL ANDA 25 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-485 TABLET 200 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-561 TABLET 100 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-562 TABLET 300 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate HUMAN PRESCRIPTION DRUG LABEL 1 16729-563 TABLET 400 mg ORAL ANDA 26 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 42385-927 TABLET, FILM COATED 200 mg ORAL ANDA 11 sections
Hydroxychloroquine Sulfate Human Prescription Drug Label 1 43353-051 TABLET 200 mg ORAL NDA AUTHORIZED GENERIC 24 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-131 TABLET 400 mg ORAL ANDA 28 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-132 TABLET 300 mg ORAL ANDA 28 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-133 TABLET 100 mg ORAL ANDA 28 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-721 TABLET 200 mg ORAL ANDA 28 sections
HYDROXYCHLOROQUINE SULFATE Human Prescription Drug Label 1 43598-721 TABLET 200 mg ORAL ANDA 28 sections