talbutal 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
hypnotics, barbituric acid derivatives	2556	115-44-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

profundol
5-Allyl-5-sec-butylbarbituric acid
lotusate
5-Allyl-5-(1-methylpropyl) barbituric acid
talbutal

Molecular weight: 224.26
Formula: C11H16N2O3
CLOGP: 1.63
LIPINSKI: 0
HAC: 5
HDO: 2
TPSA: 75.27
ALOGS: -1.96
ROTB: 4

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.10	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA	SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05CA07	NERVOUS SYSTEM PSYCHOLEPTICS HYPNOTICS AND SEDATIVES Barbiturates, plain

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Insomnia	indication	193462001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.79	acidic
pKa2	9.48	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
GABA-A receptor; anion channel	Ion channel	O00591 O14764 P14867 P18505 P18507 P28472 P31644 P34903 P47869 P47870 P48169 P78334 Q16445 Q8N1C3 Q99928 Q9UN88	GBRP_HUMAN GBRD_HUMAN GBRA1_HUMAN GBRB1_HUMAN GBRG2_HUMAN GBRB3_HUMAN GBRA5_HUMAN GBRA3_HUMAN GBRA2_HUMAN GBRB2_HUMAN GBRA4_HUMAN GBRE_HUMAN GBRA6_HUMAN GBRG1_HUMAN GBRG3_HUMAN GBRT_HUMAN	POSITIVE ALLOSTERIC MODULATOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018243	VUID
N0000146574	NUI
D06887	KEGG_DRUG
4018243	VANDF
C0301407	UMLSCUI
CHEBI:134923	CHEBI
CHEMBL1200802	ChEMBL_ID
DB00306	DRUGBANK_ID
8275	PUBCHEM_CID
C446080	MESH_SUPPLEMENTAL_RECORD_UI
6	INN_ID
4YIR8202AX	UNII
89810	RXNORM
001425	NDDF
76190009	SNOMEDCT_US

Pharmaceutical products:

None