acyclovir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antivirals bicyclic heterocycle compounds 85 59277-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zovirax
  • acyclovir
  • aciclovir
  • acyclovir sodium
Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. In vitro, acyclovir triphosphate stops replication of herpes viral DNA.
  • Molecular weight: 225.21
  • Formula: C8H11N5O3
  • CLOGP: -2.02
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 114.76
  • ALOGS: -1.42
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 g O
4 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.62 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 59.06 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 22.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.71 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.85 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.354 Moderate 0.70
caco2-efflux Caco-2 efflux ratio (BA/AB) 11.776 Moderate 0.70
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.492 10^-6 cm/s Moderate 0.70
dh-clint Dog hepatocyte intrinsic clearance 0.893 uL/min/10^6 cells Moderate 0.70
dppb Dog plasma protein binding (% unbound) 81.080 % Moderate 0.70
fcs-ppb Fetal calf serum protein binding (% unbound) 86.980 % Moderate 0.70
herg hERG pIC50 3.503 pIC50 Moderate 0.70
hh-clint Human hepatocyte intrinsic clearance 1.256 uL/min/10^6 cells Moderate 0.70
hlm-clint Human liver microsomal intrinsic clearance 3.319 uL/min/mg protein Moderate 0.70
hppb Human plasma protein binding (% unbound) 77.330 % Moderate 0.70
kinase-safety-class ACVR2B,EIF2AK3,GRK2,MAP3K21,PDK1,PDK2,PRKDC 7
kinase-selectivity-class AXL,CDK1,CDK16,CDK2,CDK3,CDK7,CDK9,MAP3K21,PDK1 9
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.767 Moderate 0.70
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.265 Moderate 0.70
mh-clint Mouse hepatocyte intrinsic clearance 0.989 Moderate 0.70
mppb Mouse plasma protein binding (% unbound) 88.750 Moderate 0.70
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.178 Moderate 0.70
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 87.520 % Moderate 0.70
rat-kpuu-brain Rat brain Kpuu 0.014 % Moderate 0.70
rh-clint Rat hepatocyte intrinsic clearance 1.629 uL/min/10^6 cells Moderate 0.70
rh-fuinc Rat hepatocyte fraction unbound in incubation 96.580 % Moderate 0.70
rppb Rat plasma protein binding (% unbound) 78.480 % Moderate 0.70
solubility-dd Solubility at pH 7.4 in DMSO 963.829 uM Moderate 0.70

Approvals:

DateAgencyCompanyOrphan
March 29, 1982 FDA VALEANT BERMUDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2020.38 10.31 1159 176791 39669 90410828
White blood cell count decreased 1064.76 10.31 1469 176481 165640 90284857
Febrile neutropenia 999.75 10.31 1386 176564 156963 90293534
Neutropenia 804.93 10.31 1521 176429 223383 90227114
Platelet count decreased 783.38 10.31 1144 176806 135825 90314672
Neuropathy peripheral 725.98 10.31 1104 176846 135866 90314631
Cytokine release syndrome 637.79 10.31 490 177460 27483 90423014
Pemphigus 613.67 10.31 5 177945 326859 90123638
Synovitis 601.14 10.31 9 177941 329743 90120754
Lymphocyte count decreased 594.93 10.31 517 177433 34533 90415964
Systemic lupus erythematosus 568.50 10.31 36 177914 361860 90088637
Neutrophil count decreased 559.25 10.31 696 177254 70836 90379661
Hand deformity 558.93 10.31 4 177946 296358 90154139
Contraindicated product administered 540.69 10.31 20 177930 320119 90130378
Rheumatoid arthritis 530.43 10.31 50 177900 362564 90087933
Full blood count decreased 508.06 10.31 440 177510 29249 90421248
Thrombocytopenia 506.19 10.31 1205 176745 207520 90242977
Diarrhoea 485.35 10.31 3325 174625 935865 89514632
Glossodynia 485.19 10.31 39 177911 321740 90128757
Urine abnormality 451.57 10.31 245 177705 7492 90443005
Wound 419.45 10.31 51 177899 302929 90147568
Pericarditis 417.87 10.31 29 177921 270122 90180375
Helicobacter infection 397.99 10.31 10 177940 226840 90223657
Pneumonia 361.83 10.31 2314 175636 635745 89814752
Psoriatic arthropathy 354.59 10.31 24 177926 228311 90222186
Constipation 350.28 10.31 1278 176672 279117 90171380
Sepsis 349.37 10.31 955 176995 178859 90271638
Therapeutic product effect decreased 342.45 10.31 65 177885 277506 90172991
Cytomegalovirus infection 341.89 10.31 336 177614 26266 90424231
Joint swelling 337.95 10.31 295 177655 503005 89947492
Neurotoxicity 337.00 10.31 303 177647 21164 90429333
Arthropathy 333.36 10.31 151 177799 366091 90084406
Folliculitis 321.68 10.31 20 177930 204333 90246164
Acute kidney injury 321.45 10.31 1363 176587 319024 90131473
Muscle injury 320.99 10.31 5 177945 176649 90273848
Drug intolerance 318.21 10.31 248 177702 447343 90003154
Type 2 diabetes mellitus 316.64 10.31 21 177929 203223 90247274
Treatment failure 310.00 10.31 105 177845 303823 90146674
Discomfort 299.15 10.31 84 177866 274251 90176246
Infusion related reaction 294.87 10.31 232 177718 416548 90033949
Swelling 293.05 10.31 236 177714 418822 90031675
Urine leukocyte esterase positive 291.33 10.31 138 177812 3144 90447353
Pyrexia 290.81 10.31 2253 175697 658232 89792265
Impaired healing 282.22 10.31 58 177892 234141 90216356
Maternal exposure during pregnancy 278.79 10.31 182 177768 359881 90090616
Urinary sediment present 277.99 10.31 118 177832 2056 90448441
Hepatic enzyme increased 270.38 10.31 189 177761 360547 90089950
Irritable bowel syndrome 270.28 10.31 42 177908 207406 90243091
Alopecia 264.62 10.31 351 177599 494720 89955777
Arthralgia 256.47 10.31 736 177214 777786 89672711
Thrombosis 254.80 10.31 490 177460 72761 90377736
Pain 253.39 10.31 1053 176897 995288 89455209
Laboratory test abnormal 249.76 10.31 357 177593 41497 90409000
Pancytopenia 246.82 10.31 652 177298 119611 90330886
Hypersensitivity 242.30 10.31 323 177627 454354 89996143
Drug hypersensitivity 241.35 10.31 335 177615 463274 89987223
Red blood cells urine positive 239.39 10.31 120 177830 3105 90447392
Graft versus host disease 238.49 10.31 166 177784 7978 90442519
Crystal urine present 235.11 10.31 94 177856 1396 90449101
Multiple organ dysfunction syndrome 228.99 10.31 450 177500 67886 90382611
Injury 225.43 10.31 55 177895 197294 90253203
White blood cells urine positive 220.23 10.31 145 177805 6353 90444144
Mobility decreased 216.38 10.31 111 177839 250623 90199874
Sensitisation 212.96 10.31 121 177829 4054 90446443
Epstein-Barr virus infection 211.57 10.31 170 177780 10174 90440323
Mucosal inflammation 207.21 10.31 391 177559 57234 90393263
C-reactive protein abnormal 201.92 10.31 12 177938 127417 90323080
Ill-defined disorder 198.92 10.31 58 177892 184833 90265664
Liver injury 195.85 10.31 47 177903 170520 90279977
Neutrophil percentage increased 191.84 10.31 101 177849 2902 90447595
Lymphocyte percentage decreased 190.80 10.31 102 177848 3025 90447472
Musculoskeletal stiffness 189.05 10.31 182 177768 296350 90154147
Abdominal discomfort 189.04 10.31 410 177540 476918 89973579
Urine analysis abnormal 187.96 10.31 121 177829 5100 90445397
Joint range of motion decreased 187.17 10.31 23 177927 135620 90314877
Blood urine present 187.06 10.31 199 177751 17079 90433418
Immune effector cell-associated neurotoxicity syndrome 186.52 10.31 125 177825 5643 90444854
Condition aggravated 185.78 10.31 577 177373 594968 89855529
Polycystic ovaries 181.56 10.31 122 177828 5532 90444965
Blood cholesterol increased 179.59 10.31 92 177858 207920 90242577
Post transplant lymphoproliferative disorder 178.99 10.31 131 177819 6818 90443679
Facet joint syndrome 177.79 10.31 3 177947 98386 90352111
Bursitis 172.94 10.31 26 177924 131628 90318869
Drug ineffective 172.84 10.31 1814 176136 1382484 89068013
Product use issue 170.96 10.31 239 177711 329680 90120817
Obesity 166.96 10.31 10 177940 105497 90345000
Ejection fraction 166.45 10.31 92 177858 2919 90447578
Encephalopathy 164.33 10.31 313 177637 46131 90404366
Renal disorder 163.14 10.31 278 177672 37581 90412916
Smooth muscle cell neoplasm 160.68 10.31 70 177880 1303 90449194
Plasma cell myeloma recurrent 159.69 10.31 101 177849 4127 90446370
Lip dry 158.46 10.31 10 177940 100945 90349552
Cytomegalovirus viraemia 157.97 10.31 126 177824 7460 90443037
Acute graft versus host disease 154.39 10.31 109 177841 5359 90445138
Blister 152.85 10.31 165 177785 254833 90195664
Osteoarthritis 152.63 10.31 98 177852 195632 90254865
Acute myeloid leukaemia 151.95 10.31 195 177755 20445 90430052
Sleep disorder due to general medical condition, insomnia type 148.64 10.31 35 177915 128659 90321838
Lower respiratory tract infection 146.06 10.31 166 177784 250493 90200004
Encephalitis viral 142.31 10.31 71 177879 1818 90448679
Completed suicide 139.52 10.31 55 177895 145003 90305494
Bacterial test positive 139.46 10.31 103 177847 5436 90445061
Cytopenia 138.22 10.31 171 177779 17278 90433219
Herpes simplex 135.30 10.31 131 177819 10050 90440447
Varicella zoster virus infection 135.01 10.31 88 177862 3789 90446708
Pulmonary fibrosis 135.00 10.31 24 177926 107479 90343018
Neutropenic sepsis 133.01 10.31 171 177779 17959 90432538
Peripheral venous disease 132.65 10.31 8 177942 83913 90366584
Blood test abnormal 131.33 10.31 183 177767 20769 90429728
Blood creatinine increased 131.32 10.31 468 177482 100918 90349579
Knee arthroplasty 131.27 10.31 8 177942 83174 90367323
Urine ketone body present 130.27 10.31 74 177876 2478 90448019
Bacterial test 130.11 10.31 57 177893 1076 90449421
Herpes zoster 129.61 10.31 445 177505 94199 90356298
Hypercholesterolaemia 127.84 10.31 22 177928 100870 90349627
Wound infection 126.77 10.31 27 177923 106375 90344122
Anaemia 126.74 10.31 1151 176799 351651 90098846
Crystalluria 126.70 10.31 46 177904 516 90449981
Meningoencephalitis herpetic 125.39 10.31 60 177890 1399 90449098
Injection site pain 124.80 10.31 95 177855 173604 90276893
Culture urine positive 123.94 10.31 83 177867 3742 90446755
Bronchopulmonary aspergillosis 122.89 10.31 131 177819 11267 90439230
Pathogen resistance 122.37 10.31 112 177838 8003 90442494
Prescribed overdose 122.14 10.31 22 177928 97603 90352894
Haemoglobin decreased 120.36 10.31 632 177318 161324 90289173
Psoriasis 116.52 10.31 73 177877 147681 90302816
Cytomegalovirus infection reactivation 114.40 10.31 106 177844 7694 90442803
Clostridium difficile colitis 113.60 10.31 195 177755 26511 90423986
Inflammation 113.30 10.31 110 177840 178482 90272015
Hip arthroplasty 112.63 10.31 10 177940 76198 90374299
Lymphopenia 112.04 10.31 178 177772 22703 90427794
Musculoskeletal pain 111.54 10.31 103 177847 171148 90279349
Red blood cell count decreased 111.46 10.31 267 177683 46084 90404413
Death 110.71 10.31 1376 176574 455175 89995322
Acute graft versus host disease in skin 109.88 10.31 84 177866 4672 90445825
General physical health deterioration 108.46 10.31 347 177603 354768 90095729
Sleep disorder 104.98 10.31 141 177809 197889 90252608
Septic shock 103.48 10.31 382 177568 83778 90366719
Autoimmune disorder 103.47 10.31 14 177936 76730 90373767
Blood potassium decreased 103.22 10.31 264 177686 47463 90403034
Haemophagocytic lymphohistiocytosis 102.88 10.31 139 177811 15320 90435177
Fibromyalgia 102.28 10.31 154 177796 206115 90244382
Haemoglobin urine present 101.83 10.31 43 177907 739 90449758
Deep vein thrombosis 100.47 10.31 401 177549 91219 90359278
Pre-engraftment immune reaction 99.98 10.31 32 177918 236 90450261
Intentional product use issue 99.02 10.31 171 177779 216721 90233776
Wheezing 98.72 10.31 199 177751 237881 90212616
Sciatica 98.21 10.31 38 177912 101344 90349153
Fatigue 97.95 10.31 2959 174991 1151064 89299433
Live birth 96.46 10.31 19 177931 79088 90371409
Intentional overdose 96.29 10.31 32 177918 93802 90356695
Red blood cell sedimentation rate increased 96.28 10.31 22 177928 82573 90367924
Grip strength decreased 96.01 10.31 31 177919 92545 90357952
Human herpesvirus 6 infection 95.94 10.31 68 177882 3364 90447133
Aplastic anaemia 95.54 10.31 124 177826 13145 90437352
Ejection fraction abnormal 95.32 10.31 60 177890 2431 90448066
Nephropathy toxic 95.17 10.31 121 177829 12567 90437930
Renal failure 91.05 10.31 502 177448 130505 90319992
Specific gravity urine decreased 90.83 10.31 40 177910 765 90449732
Gait inability 90.83 10.31 92 177858 146364 90304133
Drug resistance 90.68 10.31 191 177759 30258 90420239
Bone erosion 90.50 10.31 3 177947 53018 90397479
Urinary tract infection 90.09 10.31 957 176993 304675 90145822
Respiratory failure 89.95 10.31 465 177485 117953 90332544
Light chain analysis increased 89.86 10.31 49 177901 1513 90448984
Encephalitis 89.62 10.31 110 177840 11024 90439473
Tumour lysis syndrome 89.47 10.31 110 177840 11042 90439455
Red cell distribution width increased 89.33 10.31 115 177835 12092 90438405
Unevaluable event 88.71 10.31 273 177677 54575 90395922
Ageusia 88.45 10.31 132 177818 15944 90434553
Rhinitis allergic 88.34 10.31 135 177815 16650 90433847
Nephrectomy 86.73 10.31 52 177898 1929 90448568
Weight increased 85.70 10.31 476 177474 417451 90033046
Gastrointestinal disorder 84.66 10.31 242 177708 256445 90194052
Cytomegalovirus test positive 84.23 10.31 64 177886 3527 90446970
Aspergillus infection 84.01 10.31 105 177845 10718 90439779
Toxoplasmosis 83.76 10.31 49 177901 1736 90448761
Prescribed underdose 83.51 10.31 22 177928 74997 90375500
Drug abuse 81.20 10.31 30 177920 82317 90368180
COVID-19 80.65 10.31 588 177362 168255 90282242
Injection site reaction 80.52 10.31 40 177910 92040 90358457
Lower limb fracture 80.48 10.31 33 177917 84980 90365517
Exposure during pregnancy 79.92 10.31 223 177727 238187 90212310
Road traffic accident 78.40 10.31 58 177892 107568 90342929
COVID-19 pneumonia 77.67 10.31 133 177817 18044 90432453
Overdose 76.96 10.31 119 177831 157590 90292907
Acute graft versus host disease in intestine 76.78 10.31 49 177901 2034 90448463
Nitrite urine present 76.72 10.31 39 177911 1040 90449457
Lupus-like syndrome 76.16 10.31 5 177945 48841 90401656
Bacterial sepsis 75.91 10.31 69 177881 4886 90445611
Foot deformity 75.58 10.31 13 177937 59638 90390859
Encephalitis cytomegalovirus 75.45 10.31 34 177916 688 90449809
Stem cell transplant 75.27 10.31 49 177901 2105 90448392
Graft versus host disease in gastrointestinal tract 74.98 10.31 65 177885 4323 90446174
Cardiac disorder 74.88 10.31 264 177686 56608 90393889
Coeliac disease 74.49 10.31 3 177947 44607 90405890
Hypogammaglobulinaemia 74.13 10.31 98 177852 10576 90439921
Migraine 73.19 10.31 166 177784 190226 90260271
Acute myeloid leukaemia recurrent 72.39 10.31 47 177903 2010 90448487
Haemorrhage intracranial 71.56 10.31 116 177834 15046 90435451
Bacteraemia 71.25 10.31 144 177806 22156 90428341
Respiratory syncytial virus infection 70.91 10.31 95 177855 10385 90440112
Tremor 70.62 10.31 529 177421 152644 90297853
Plasmacytoma 70.46 10.31 52 177898 2741 90447756
Chronic graft versus host disease 70.09 10.31 61 177889 4078 90446419
Carpal tunnel syndrome 69.98 10.31 149 177801 23779 90426718
Enterococcal infection 69.81 10.31 92 177858 9899 90440598
Monocyte percentage increased 69.78 10.31 38 177912 1170 90449327
Renal impairment 68.64 10.31 397 177553 105024 90345473
Antiviral drug level above therapeutic 68.16 10.31 15 177935 15 90450482
Hypothyroidism 67.71 10.31 244 177706 52883 90397614
Pneumonia fungal 67.45 10.31 76 177874 6955 90443542
Toxicity to various agents 66.22 10.31 315 177635 287531 90162966
Hepatic cirrhosis 65.90 10.31 21 177929 63232 90387265
Graft versus host disease in skin 65.68 10.31 57 177893 3796 90446701
Haematocrit decreased 64.68 10.31 205 177745 41627 90408870
Arthritis 64.21 10.31 146 177804 167169 90283328
Blepharospasm 64.16 10.31 15 177935 55430 90395067
Alanine aminotransferase increased 64.08 10.31 425 177525 117913 90332584
Lung disorder 64.07 10.31 123 177827 149760 90300737
Influenza 63.65 10.31 480 177470 138784 90311713
Muscle spasms 63.46 10.31 765 177185 251118 90199379
Exostosis 62.23 10.31 14 177936 53120 90397377
Flushing 62.08 10.31 340 177610 88151 90362346
Atrial fibrillation 61.90 10.31 462 177488 133149 90317348
Pleocytosis 61.84 10.31 33 177917 975 90449522
Osteoporosis 60.57 10.31 60 177890 96471 90354026
Thrombotic microangiopathy 60.56 10.31 110 177840 15633 90434864
Inappropriate schedule of product administration 59.86 10.31 128 177822 149805 90300692
Intentional product misuse 58.20 10.31 54 177896 89550 90360947
Burning sensation 58.14 10.31 263 177687 63189 90387308
Pneumonia cytomegaloviral 57.07 10.31 48 177902 3063 90447434
Product quality issue 56.17 10.31 44 177906 79281 90371216
Suicide attempt 55.73 10.31 40 177910 75359 90375138
Thyroxine free increased 55.73 10.31 31 177919 996 90449501
Tooth disorder 55.24 10.31 160 177790 30930 90419567
Dysgeusia 55.18 10.31 227 177723 52333 90398164
Mucormycosis 54.25 10.31 51 177899 3770 90446727
Drug reaction with eosinophilia and systemic symptoms 54.17 10.31 196 177754 42562 90407935
Joint dislocation 53.74 10.31 11 177939 44571 90405926
Systemic candida 53.47 10.31 57 177893 4902 90445595
Rash 52.90 10.31 1985 175965 794115 89656382
Disseminated mucormycosis 52.86 10.31 26 177924 645 90449852
Epstein-Barr virus associated lymphoproliferative disorder 52.78 10.31 43 177907 2624 90447873
Underdose 52.72 10.31 20 177930 53997 90396500
Therapeutic product effect incomplete 52.71 10.31 199 177751 193697 90256800
Medication error 52.67 10.31 53 177897 84599 90365898
Night sweats 52.18 10.31 109 177841 128657 90321840
Vision blurred 52.01 10.31 383 177567 109910 90340587
Monocyte count decreased 51.75 10.31 42 177908 2549 90447948
Systemic mycosis 51.50 10.31 34 177916 1496 90449001
Herpes virus infection 51.26 10.31 63 177887 6321 90444176
Pregnancy 51.23 10.31 29 177921 62018 90388479
Immune thrombocytopenia 51.12 10.31 93 177857 13233 90437264
Hyperbilirubinaemia 50.62 10.31 95 177855 13841 90436656
Leukopenia 50.54 10.31 355 177595 100355 90350142
Blood thyroid stimulating hormone increased 50.12 10.31 75 177875 9080 90441417
Chills 50.06 10.31 436 177514 131545 90318952
Dry mouth 49.97 10.31 189 177761 183870 90266627
Hypokalaemia 49.66 10.31 433 177517 130683 90319814
Pulmonary embolism 49.54 10.31 432 177518 130388 90320109
Laryngitis 49.18 10.31 19 177931 50734 90399763
Cystitis haemorrhagic 48.52 10.31 57 177893 5456 90445041
Urinary casts 48.48 10.31 26 177924 776 90449721
Dehydration 48.27 10.31 589 177361 193858 90256639
Nail disorder 48.21 10.31 28 177922 59039 90391458
Engraftment syndrome 48.07 10.31 25 177925 700 90449797
Frequent bowel movements 47.89 10.31 26 177924 56909 90393588
Skin discolouration 47.80 10.31 193 177757 44122 90406375
Diffuse large B-cell lymphoma 47.58 10.31 71 177879 8574 90441923
Contusion 47.24 10.31 294 177656 250922 90199575
Protein urine present 46.78 10.31 63 177887 6921 90443576
C-reactive protein 46.66 10.31 4 177946 31363 90419134
Depression 46.64 10.31 372 177578 300229 90150268
Factor XIII deficiency 46.21 10.31 14 177936 84 90450413
Adenovirus infection 46.12 10.31 51 177899 4571 90445926
Urine leukocyte esterase 45.89 10.31 16 177934 158 90450339
Incorrect route of product administration 45.77 10.31 21 177929 50605 90399892
Cytomegalovirus chorioretinitis 45.77 10.31 38 177912 2381 90448116
Asthma 45.74 10.31 283 177667 241877 90208620
Injection site bruising 45.31 10.31 23 177927 52284 90398213
Staphylococcal infection 45.30 10.31 202 177748 48237 90402260
Ophthalmic herpes simplex 45.02 10.31 23 177927 620 90449877
Rash maculo-papular 44.73 10.31 179 177771 40754 90409743
Rash pruritic 44.34 10.31 295 177655 81919 90368578
Band sensation 44.25 10.31 28 177922 1145 90449352
Cells in urine 44.11 10.31 16 177934 179 90450318
CD4 lymphocytes decreased 44.05 10.31 31 177919 1516 90448981
Cataract 44.03 10.31 267 177683 71825 90378672
Sedation 43.53 10.31 20 177930 48151 90402346
Onychomycosis 43.47 10.31 10 177940 37366 90413131
Retinitis 43.33 10.31 11 177939 38447 90412050
Venoocclusive liver disease 43.13 10.31 56 177894 5937 90444560
Bradycardia 42.92 10.31 297 177653 83550 90366947
Back injury 42.68 10.31 19 177931 46603 90403894
Haematotoxicity 42.52 10.31 83 177867 12452 90438045
Nervous system disorder 42.16 10.31 115 177835 21478 90429019
Wrong technique in product usage process 42.08 10.31 47 177903 71524 90378973
Escherichia bacteraemia 41.92 10.31 54 177896 5681 90444816
Blood thyroid stimulating hormone decreased 41.88 10.31 54 177896 5686 90444811
Seasonal allergy 41.53 10.31 119 177831 22864 90427633
Retinitis viral 41.03 10.31 17 177933 278 90450219
Herpes simplex viraemia 41.01 10.31 19 177931 411 90450086
Anaphylactic reaction 40.84 10.31 68 177882 87456 90363041
Mean cell haemoglobin decreased 40.65 10.31 53 177897 5642 90444855
Sleep apnoea syndrome 40.61 10.31 146 177804 31601 90418896
Oedema 40.51 10.31 229 177721 200066 90250431
Intentional self-injury 40.39 10.31 5 177945 29329 90421168
Pneumonia bacterial 40.16 10.31 82 177868 12708 90437789
Injection site swelling 40.13 10.31 35 177915 59804 90390693
Multiple sclerosis relapse 40.12 10.31 206 177744 52099 90398398
Aspartate aminotransferase increased 40.05 10.31 342 177608 102595 90347902
Human chorionic gonadotropin increased 39.83 10.31 32 177918 1914 90448583
Pulmonary thrombosis 39.74 10.31 70 177880 9712 90440785
Chronic lymphocytic leukaemia 38.80 10.31 39 177911 3131 90447366
Differentiation syndrome 38.67 10.31 27 177923 1304 90449193
Post herpetic neuralgia 38.45 10.31 36 177914 2648 90447849
Multiple allergies 38.31 10.31 89 177861 15057 90435440
Leukocyturia 38.25 10.31 29 177921 1593 90448904
Antinuclear antibody negative 38.16 10.31 16 177934 270 90450227
Acute lymphocytic leukaemia recurrent 38.03 10.31 36 177914 2685 90447812
Back pain 37.94 10.31 852 177098 316323 90134174
Choroidal effusion 37.92 10.31 22 177928 767 90449730
Product dose omission issue 37.92 10.31 793 177157 290894 90159603
Injection site erythema 37.74 10.31 86 177864 98416 90352081
Stomatitis 37.25 10.31 352 177598 274346 90176151
Disability 36.68 10.31 17 177933 40728 90409769
Congenital cytomegalovirus infection 36.53 10.31 13 177937 137 90450360
Therapeutic response decreased 36.31 10.31 76 177874 89653 90360844
Hypertension 36.28 10.31 656 177294 456876 89993621
Oral herpes 36.15 10.31 146 177804 33378 90417119
Joint stiffness 36.07 10.31 61 177889 77981 90372516
Rash macular 36.00 10.31 136 177814 30144 90420353
Escherichia infection 35.48 10.31 89 177861 15806 90434691
CSF protein increased 35.37 10.31 21 177929 765 90449732
Status epilepticus 35.35 10.31 99 177851 18775 90431722
Blood bilirubin increased 35.31 10.31 174 177776 43296 90407201
Clostridium difficile infection 35.29 10.31 153 177797 36092 90414405
Monoclonal immunoglobulin increased 35.23 10.31 17 177933 404 90450093
Pulmonary mucormycosis 35.01 10.31 19 177931 581 90449916
Walking aid user 34.89 10.31 13 177937 35493 90415004
Plasma cell leukaemia 34.83 10.31 24 177926 1134 90449363
Accidental exposure to product 34.69 10.31 20 177930 42346 90408151
Blood pressure systolic increased 34.64 10.31 38 177912 58307 90392190
Disseminated intravascular coagulation 34.63 10.31 107 177843 21431 90429066
Plasma cell myeloma refractory 34.42 10.31 23 177927 1033 90449464
Abdominal wall infection 34.28 10.31 12 177938 120 90450377
Liver function test increased 34.23 10.31 72 177878 84783 90365714
Encephalitis autoimmune 34.19 10.31 30 177920 2028 90448469
Spinal fracture 34.13 10.31 108 177842 21908 90428589
Staphylococcal sepsis 34.13 10.31 64 177886 9319 90441178
Acute generalised exanthematous pustulosis 34.09 10.31 80 177870 13623 90436874
Blood lactate dehydrogenase decreased 34.07 10.31 14 177936 224 90450273
Varicella 33.99 10.31 32 177918 2370 90448127
Sinusitis 33.86 10.31 472 177478 342616 90107881
Toxic encephalopathy 33.74 10.31 61 177889 8638 90441859
Staphylococcal bacteraemia 33.70 10.31 56 177894 7413 90443084
Extravasation 33.62 10.31 35 177915 2929 90447568
Nephropathy 33.60 10.31 63 177887 9172 90441325
Venoocclusive disease 33.39 10.31 32 177918 2423 90448074
Full blood count increased 33.21 10.31 24 177926 1224 90449273
Congenital nail disorder 33.06 10.31 11 177939 93 90450404
Microtia 32.97 10.31 16 177934 385 90450112
Nausea 32.89 10.31 2567 175383 1107749 89342748
Coombs positive haemolytic anaemia 32.78 10.31 17 177933 473 90450024
Cytomegalovirus hepatitis 32.67 10.31 16 177934 393 90450104
Red blood cell count increased 32.62 10.31 38 177912 3605 90446892
Brain oedema 32.37 10.31 91 177859 17294 90433203
Epilepsy 32.12 10.31 71 177879 82135 90368362
Injection site pruritus 32.03 10.31 35 177915 53799 90396698
Rhabdomyolysis 31.99 10.31 32 177918 51224 90399273
Mean cell haemoglobin concentration increased 31.84 10.31 18 177932 597 90449900
Fusarium infection 31.55 10.31 22 177928 1060 90449437
Mental status changes 31.55 10.31 172 177778 44507 90405990
Pain in extremity 31.44 10.31 660 177290 449869 90000628
Klebsiella test positive 31.37 10.31 25 177925 1478 90449019
Dry skin 31.36 10.31 287 177663 87786 90362711
Band neutrophil percentage increased 31.30 10.31 13 177937 214 90450283
Sepsis syndrome 31.25 10.31 21 177929 952 90449545
Urobilinogen urine increased 31.22 10.31 14 177936 280 90450217
Idiopathic pneumonia syndrome 31.19 10.31 16 177934 435 90450062
CSF oligoclonal band present 31.19 10.31 16 177934 435 90450062
Red blood cells urine 31.17 10.31 17 177933 525 90449972
Engraft failure 30.87 10.31 15 177935 362 90450135
Colitis ulcerative 30.82 10.31 44 177906 60222 90390275
Toxic epidermal necrolysis 30.68 10.31 136 177814 32392 90418105
Hypoxia 30.55 10.31 245 177705 72154 90378343
Maternal exposure timing unspecified 30.55 10.31 4 177946 22479 90428018
Creutzfeldt-Jakob disease 30.15 10.31 12 177938 176 90450321
Pneumonia influenzal 30.10 10.31 29 177921 2211 90448286
Specific gravity urine increased 29.89 10.31 13 177937 241 90450256
Herpes simplex pneumonia 29.80 10.31 10 177940 87 90450410
Infection reactivation 29.69 10.31 27 177923 1913 90448584
Meningitis aseptic 29.52 10.31 50 177900 6723 90443774
Full blood count abnormal 29.37 10.31 146 177804 36451 90414046
Obliterative bronchiolitis 29.23 10.31 31 177919 2650 90447847
Blood brain barrier defect 28.98 10.31 11 177939 141 90450356
Infusion site pain 28.94 10.31 95 177855 19643 90430854
Fryns syndrome 28.90 10.31 9 177941 60 90450437
Blood lactate dehydrogenase increased 28.81 10.31 114 177836 25818 90424679
Hepatitis fulminant 28.61 10.31 37 177913 3908 90446589
CSF measles antibody positive 28.52 10.31 9 177941 63 90450434
Diffuse cutaneous mastocytosis 28.50 10.31 8 177942 35 90450462
Lymphadenopathy 28.24 10.31 170 177780 45605 90404892
Eczema herpeticum 28.06 10.31 12 177938 213 90450284
Herpes simplex reactivation 28.05 10.31 20 177930 999 90449498
Sopor 27.86 10.31 7 177943 24637 90425860
Tri-iodothyronine free increased 27.81 10.31 12 177938 218 90450279
Infected neoplasm 27.72 10.31 14 177936 368 90450129
Rubella antibody positive 27.70 10.31 9 177941 70 90450427
Primary myelofibrosis 27.48 10.31 9 177941 72 90450425
Bone pain 27.39 10.31 212 177738 61771 90388726
Herpes ophthalmic 27.30 10.31 23 177927 1471 90449026
Rhinovirus infection 27.30 10.31 45 177905 5918 90444579
Rectal haemorrhage 27.25 10.31 78 177872 82666 90367831
Pleural effusion 27.24 10.31 338 177612 111653 90338844
Urine oxalate increased 27.22 10.31 12 177938 230 90450267
Neutropenic colitis 27.18 10.31 37 177913 4106 90446391
Deafness congenital 27.16 10.31 10 177940 117 90450380
Gastritis fungal 27.11 10.31 11 177939 170 90450327
pH urine increased 27.08 10.31 14 177936 387 90450110
Suicidal ideation 27.08 10.31 66 177884 73789 90376708
Tri-iodothyronine free decreased 27.02 10.31 14 177936 389 90450108
Partial seizures 27.00 10.31 50 177900 7210 90443287
Myositis 27.00 10.31 7 177943 24121 90426376
Ulcer haemorrhage 26.96 10.31 9 177941 26312 90424185
Macular degeneration 26.96 10.31 21 177929 37949 90412548
Red cell distribution width decreased 26.84 10.31 27 177923 2169 90448328
Fungaemia 26.80 10.31 33 177917 3317 90447180
Drug dependence 26.77 10.31 12 177938 29315 90421182
Feeling abnormal 26.61 10.31 469 177481 166766 90283731
Myelocyte count increased 26.60 10.31 14 177936 402 90450095
Lung infiltration 26.53 10.31 78 177872 15204 90435293
Immune recovery uveitis 26.41 10.31 8 177942 48 90450449
Herpes simplex encephalitis 26.38 10.31 14 177936 409 90450088
Acute lymphocytic leukaemia 25.99 10.31 30 177920 2818 90447679
Metastases to liver 25.96 10.31 12 177938 28795 90421702
Hypoglycaemia 25.94 10.31 62 177888 69786 90380711
Arteritis infective 25.89 10.31 9 177941 88 90450409
Magnetic resonance imaging abnormal 25.76 10.31 33 177917 3453 90447044
Chest discomfort 25.69 10.31 398 177552 137967 90312530
Dilatation intrahepatic duct acquired 25.69 10.31 17 177933 751 90449746
Hospice care 25.62 10.31 58 177892 9646 90440851
Ureaplasma infection 25.46 10.31 18 177932 887 90449610
Lactose intolerance 25.06 10.31 32 177918 3337 90447160
Skin disorder 25.04 10.31 140 177810 36566 90413931
Autoimmune thyroiditis 25.02 10.31 43 177907 5850 90444647
Acute graft versus host disease in liver 24.94 10.31 17 177933 789 90449708
Acquired macroglossia 24.85 10.31 11 177939 213 90450284
Meningitis listeria 24.50 10.31 16 177934 691 90449806
Graft versus host disease in liver 24.45 10.31 18 177932 945 90449552
Blood pressure diastolic decreased 24.45 10.31 11 177939 26815 90423682
Anti-thyroid antibody positive 24.34 10.31 14 177936 480 90450017
Procedural pain 24.26 10.31 18 177932 33342 90417155
Congenital diaphragmatic hernia 24.21 10.31 11 177939 227 90450270
Thyroxine free decreased 24.16 10.31 17 177933 831 90449666
Skin exfoliation 24.02 10.31 221 177729 67692 90382805
Band neutrophil count increased 24.00 10.31 13 177937 396 90450101
Thyroid stimulating immunoglobulin 23.90 10.31 8 177942 69 90450428
Human herpesvirus 6 encephalitis 23.88 10.31 13 177937 400 90450097
Neutrophil count increased 23.81 10.31 88 177862 19302 90431195
Injection site haemorrhage 23.72 10.31 13 177937 28305 90422192
Lymph node palpable 23.66 10.31 9 177941 116 90450381
Device malfunction 23.63 10.31 6 177944 20971 90429526
Human herpesvirus 6 infection reactivation 23.58 10.31 15 177935 619 90449878
Agranulocytosis 23.55 10.31 133 177817 34869 90415628
Blood thyroid stimulating hormone abnormal 23.47 10.31 18 177932 1006 90449491
Target skin lesion 23.46 10.31 9 177941 119 90450378
Hyperuricaemia 23.41 10.31 45 177905 6674 90443823
Mean cell volume decreased 23.37 10.31 36 177914 4470 90446027
Acute disseminated encephalomyelitis 23.28 10.31 11 177939 249 90450248
Pulmonary alveolar haemorrhage 23.18 10.31 42 177908 5956 90444541
Klebsiella bacteraemia 23.15 10.31 27 177923 2565 90447932
Pseudomonas infection 23.11 10.31 73 177877 14792 90435705
Tonsillar haemorrhage 23.08 10.31 11 177939 254 90450243
Rash papular 23.03 10.31 90 177860 20265 90430232
Myelocyte percentage increased 23.01 10.31 10 177940 185 90450312
Pulmonary oedema 22.97 10.31 204 177746 61876 90388621
Bacterial infection 22.85 10.31 99 177851 23345 90427152
Device expulsion 22.80 10.31 28 177922 40858 90409639
Bone marrow failure 22.72 10.31 124 177826 32097 90418400
Hordeolum 22.58 10.31 37 177913 4841 90445656
Cellulitis staphylococcal 22.54 10.31 17 177933 926 90449571
Female genital tract fistula 22.40 10.31 4 177946 17864 90432633
Gait disturbance 22.39 10.31 368 177582 260128 90190369
Fungal infection 22.35 10.31 152 177798 42509 90407988
Infusion site reaction 22.33 10.31 5 177945 19034 90431463
Renal tubular necrosis 22.20 10.31 71 177879 14484 90436013
Cytokine storm 22.16 10.31 14 177936 571 90449926
Dyslalia 21.88 10.31 15 177935 703 90449794
Focal myositis 21.80 10.31 6 177944 24 90450473
Haemodialysis 21.69 10.31 51 177899 8696 90441801
Enterocolitis 21.62 10.31 57 177893 10433 90440064
Renal tubular disorder 21.59 10.31 29 177921 3178 90447319
Geotrichum infection 21.49 10.31 14 177936 602 90449895
Monocyte count increased 21.43 10.31 52 177898 9045 90441452
Cytomegalovirus mucocutaneous ulcer 21.37 10.31 7 177943 56 90450441
Varicella virus test positive 21.24 10.31 9 177941 156 90450341
Antineutrophil cytoplasmic antibody positive 21.23 10.31 15 177935 738 90449759
Mean cell haemoglobin concentration decreased 21.06 10.31 34 177916 4394 90446103
Large intestine infection 20.98 10.31 26 177924 2631 90447866
Increased tendency to bruise 20.94 10.31 61 177889 11829 90438668
Peripheral sensory neuropathy 20.86 10.31 52 177898 9198 90441299
Meningitis bacterial 20.79 10.31 21 177929 1696 90448801
Herpes zoster meningoencephalitis 20.77 10.31 12 177938 415 90450082
Body height decreased 20.75 10.31 61 177889 11888 90438609
Pneumonia pneumococcal 20.63 10.31 26 177924 2676 90447821
Splenomegaly 20.59 10.31 64 177886 12860 90437637
Listeriosis 20.52 10.31 21 177929 1722 90448775
Escherichia sepsis 20.32 10.31 39 177911 5777 90444720
Mantle cell lymphoma 20.25 10.31 14 177936 665 90449832
Amyloidosis 20.25 10.31 18 177932 1238 90449259
Bilirubin urine present 20.18 10.31 7 177943 68 90450429
Eosinophil count increased 20.12 10.31 64 177886 13017 90437480
Posterior reversible encephalopathy syndrome 20.02 10.31 92 177858 22247 90428250
Mitochondrial DNA mutation 19.99 10.31 12 177938 446 90450051
Immune system disorder 19.94 10.31 60 177890 11845 90438652
Blastomycosis 19.92 10.31 12 177938 449 90450048
Muscle spasticity 19.89 10.31 24 177926 35298 90415199
Corneal lesion 19.81 10.31 6 177944 36 90450461
Device difficult to use 19.77 10.31 5 177945 17520 90432977
White blood cells urine 19.75 10.31 12 177938 456 90450041
Epstein-Barr viraemia 19.69 10.31 19 177931 1451 90449046
Immunosuppressant drug level increased 19.67 10.31 34 177916 4646 90445851
Lipaemic index score 19.57 10.31 7 177943 75 90450422
Meningitis 19.47 10.31 48 177902 8433 90442064
Bone marrow transplant 19.45 10.31 15 177935 845 90449652
Neuralgia 19.44 10.31 117 177833 31383 90419114
Breast cancer female 19.40 10.31 3 177947 14883 90435614
Dyspepsia 19.39 10.31 273 177677 197887 90252610
Haemorrhagic disorder 19.36 10.31 16 177934 996 90449501
Leukaemia 19.35 10.31 35 177915 4957 90445540
C-reactive protein increased 19.16 10.31 246 177704 181143 90269354
Hallucination, visual 19.16 10.31 93 177857 22999 90427498
Myeloblast percentage decreased 19.14 10.31 6 177944 41 90450456
Blood pressure fluctuation 19.09 10.31 47 177903 52366 90398131
Ear swelling 19.05 10.31 21 177929 1876 90448621
Serotonin syndrome 19.04 10.31 28 177922 37859 90412638
Primary adrenal insufficiency 18.94 10.31 10 177940 289 90450208
Malaise 18.91 10.31 949 177001 585037 89865460
Nystagmus 18.86 10.31 43 177907 7184 90443313
Temperature regulation disorder 18.86 10.31 3 177947 14576 90435921
Hypoglossal nerve paralysis 18.80 10.31 5 177945 17 90450480
Sedation complication 18.80 10.31 5 177945 16939 90433558
Glomerulonephritis chronic 18.76 10.31 8 177942 141 90450356
Pneumocystis jirovecii pneumonia 18.62 10.31 88 177862 21528 90428969
Creatinine urine decreased 18.60 10.31 10 177940 300 90450197
Capillary leak syndrome 18.59 10.31 25 177925 2742 90447755
Drug tolerance 18.57 10.31 6 177944 17910 90432587
Blood creatinine decreased 18.40 10.31 40 177910 6475 90444022
Klebsiella infection 18.30 10.31 53 177897 10244 90440253
Serum ferritin increased 18.26 10.31 43 177907 7338 90443159
Pneumonia viral 18.24 10.31 48 177902 8775 90441722
T-cell lymphoma 18.23 10.31 14 177936 784 90449713
Enterococcal sepsis 18.18 10.31 19 177931 1597 90448900
Blood urea increased 18.16 10.31 112 177838 30301 90420196
Stevens-Johnson syndrome 18.06 10.31 109 177841 29267 90421230
Toxic neuropathy 18.02 10.31 12 177938 536 90449961
Splenic vein thrombosis 18.01 10.31 11 177939 422 90450075
Vaginal cellulitis 17.95 10.31 7 177943 97 90450400
Abdominal wall wound 17.95 10.31 7 177943 97 90450400
Jarisch-Herxheimer reaction 17.94 10.31 11 177939 425 90450072
Central nervous system lesion 17.93 10.31 57 177893 11589 90438908
Drug withdrawal syndrome 17.85 10.31 18 177932 28705 90421792
Abortion spontaneous 17.77 10.31 51 177899 54005 90396492
Campylobacter gastroenteritis 17.75 10.31 14 177936 815 90449682
Pseudomonal sepsis 17.75 10.31 31 177919 4271 90446226
Extrapyramidal disorder 17.73 10.31 5 177945 16298 90434199
Organic brain syndrome 17.67 10.31 9 177941 241 90450256
Viraemia 17.67 10.31 19 177931 1650 90448847
Anxiety 17.63 10.31 468 177482 309304 90141193
Body temperature increased 17.62 10.31 149 177801 44561 90405936
Citrobacter infection 17.58 10.31 13 177937 687 90449810
Disease progression 17.55 10.31 417 177533 156198 90294299
Septic embolus 17.50 10.31 15 177935 982 90449515
Obstructive airways disorder 17.50 10.31 15 177935 25854 90424643
Gastroenteritis salmonella 17.45 10.31 14 177936 836 90449661
Acute respiratory distress syndrome 17.36 10.31 106 177844 28580 90421917
Actinomycotic sepsis 17.34 10.31 9 177941 251 90450246
Stenotrophomonas infection 17.22 10.31 23 177927 2506 90447991
Genital herpes 17.17 10.31 21 177929 2097 90448400
Metapneumovirus pneumonia 17.14 10.31 6 177944 60 90450437
Fungal sepsis 17.12 10.31 18 177932 1523 90448974
Chronic sinusitis 17.10 10.31 13 177937 23789 90426708
Tumour flare 17.10 10.31 12 177938 584 90449913
Hepatic function abnormal 17.07 10.31 152 177798 46136 90404361
Eosinophil percentage decreased 17.05 10.31 9 177941 260 90450237
Angle closure glaucoma 17.03 10.31 24 177926 2751 90447746
Thunderclap headache 17.00 10.31 10 177940 358 90450139
Monocyte percentage decreased 16.99 10.31 9 177941 262 90450235
Craniofacial deformity 16.94 10.31 8 177942 181 90450316
Urinary tract infection enterococcal 16.93 10.31 25 177925 2991 90447506
Alpha haemolytic streptococcal infection 16.89 10.31 19 177931 1735 90448762
Viral infection 16.85 10.31 139 177811 41275 90409222
Eye swelling 16.79 10.31 107 177843 29279 90421218
Pulmonary hypoplasia 16.77 10.31 10 177940 367 90450130
Fat necrosis 16.76 10.31 13 177937 739 90449758
Pulmonary arterial hypertension 16.74 10.31 16 177934 26171 90424326
Oropharyngeal pain 16.56 10.31 318 177632 114869 90335628
Bone lesion 16.47 10.31 38 177912 6399 90444098
Candida infection 16.47 10.31 119 177831 33938 90416559
Pulmonary sepsis 16.30 10.31 21 177929 2210 90448287
Staphylococcus test positive 16.26 10.31 30 177920 4315 90446182
Anaphylactic shock 16.25 10.31 23 177927 31594 90418903
Radiculopathy 16.23 10.31 8 177942 18497 90432000
Epstein-Barr virus infection reactivation 16.23 10.31 18 177932 1619 90448878
Delayed engraftment 16.18 10.31 7 177943 128 90450369
Drug interaction 16.17 10.31 416 177534 276037 90174460
Syncope 16.03 10.31 357 177593 132306 90318191
Blast cell count increased 16.00 10.31 11 177939 518 90449979
Necrotising herpetic retinopathy 15.98 10.31 7 177943 132 90450365
Antiphospholipid syndrome 15.98 10.31 21 177929 2253 90448244
Factor XIII Inhibition 15.97 10.31 5 177945 34 90450463
Small intestine adenocarcinoma 15.97 10.31 5 177945 34 90450463
Injection site mass 15.96 10.31 12 177938 22078 90428419
Hyperplasia 15.95 10.31 15 177935 1109 90449388
Thyroid stimulating immunoglobulin increased 15.89 10.31 7 177943 134 90450363
Adverse reaction 15.89 10.31 21 177929 29691 90420806
Haemorrhagic occlusive retinal vasculitis 15.87 10.31 6 177944 76 90450421
Metastases to bone 15.83 10.31 16 177934 25489 90425008
White blood cell disorder 15.82 10.31 24 177926 2940 90447557
Therapeutic response shortened 15.81 10.31 13 177937 22866 90427631
Haematuria 15.71 10.31 120 177830 34817 90415680
Basophil percentage decreased 15.71 10.31 3 177947 0 90450497
Needle issue 15.67 10.31 4 177946 13930 90436567
Basophil count increased 15.65 10.31 15 177935 1136 90449361
Ear infection 15.65 10.31 77 177873 69698 90380799
Avulsion fracture 15.59 10.31 9 177941 311 90450186
Escherichia urinary tract infection 15.56 10.31 61 177889 13754 90436743
Monoclonal immunoglobulin present 15.53 10.31 20 177930 2104 90448393
Fumbling 15.52 10.31 7 177943 142 90450355
Spinal compression fracture 15.49 10.31 65 177885 15113 90435384
Metastases to lung 15.47 10.31 6 177944 15985 90434512
Schizophrenia 15.45 10.31 5 177945 14909 90435588
Dermatitis bullous 15.44 10.31 50 177900 10266 90440231
Device related infection 15.42 10.31 95 177855 25691 90424806
Erythema multiforme 15.39 10.31 56 177894 12190 90438307
Gingival bleeding 15.35 10.31 64 177886 14839 90435658
Periorbital swelling 15.35 10.31 31 177919 4767 90445730
Hypoaesthesia oral 15.30 10.31 66 177884 15534 90434963
Eosinophil percentage increased 15.30 10.31 14 177936 1000 90449497
Refractory anaemia with an excess of blasts 15.29 10.31 10 177940 433 90450064
Hepatosplenic candidiasis 15.28 10.31 9 177941 323 90450174
Culture stool positive 15.23 10.31 9 177941 325 90450172
Superinfection bacterial 15.20 10.31 14 177936 1008 90449489
Gastrointestinal stromal tumour 15.19 10.31 16 177934 1357 90449140
Sinus tachycardia 15.18 10.31 102 177848 28411 90422086
Myocardial oedema 15.13 10.31 10 177940 441 90450056
Cerebral artery thrombosis 15.07 10.31 10 177940 444 90450053
Ingrowing nail 15.00 10.31 23 177927 2844 90447653
Skin lesion 14.98 10.31 125 177825 37240 90413257
Angioimmunoblastic T-cell lymphoma 14.97 10.31 8 177942 237 90450260
Housebound 14.94 10.31 8 177942 238 90450259
Pseudomonal bacteraemia 14.93 10.31 19 177931 1975 90448522
Liver disorder 14.92 10.31 159 177791 121110 90329387
Cerebral artery stenosis 14.90 10.31 11 177939 580 90449917
Respiratory disorder 14.84 10.31 71 177879 64745 90385752
Aplasia pure red cell 14.79 10.31 32 177918 5162 90445335
Blood parathyroid hormone decreased 14.75 10.31 3 177947 12213 90438284
Pneumonitis 14.75 10.31 142 177808 44028 90406469
Body temperature decreased 14.71 10.31 15 177935 23801 90426696
Infusion site scar 14.66 10.31 11 177939 595 90449902
Hypercreatininaemia 14.61 10.31 12 177938 741 90449756
Mycobacterium abscessus infection 14.60 10.31 14 177936 1061 90449436
Therapy non-responder 14.58 10.31 185 177765 136519 90313978
Hip fracture 14.54 10.31 113 177837 32964 90417533
Product use in unapproved indication 14.50 10.31 527 177423 335709 90114788
Diarrhoea haemorrhagic 14.47 10.31 50 177900 10613 90439884
Blood gases abnormal 14.45 10.31 13 177937 908 90449589
Delirium 14.44 10.31 133 177817 104226 90346271
Pneumonia pseudomonal 14.43 10.31 24 177926 3179 90447318
Candida sepsis 14.40 10.31 17 177933 1636 90448861
Haemolysis 14.36 10.31 43 177907 8467 90442030
Blood magnesium decreased 14.34 10.31 65 177885 15628 90434869
Leukaemia recurrent 14.32 10.31 16 177934 1451 90449046
Surgery 14.28 10.31 43 177907 44844 90405653
Oesophageal atresia 14.27 10.31 11 177939 619 90449878
Duodenal stenosis 14.27 10.31 11 177939 619 90449878
Streptococcal infection 14.26 10.31 39 177911 7294 90443203
Spondylitis 14.26 10.31 5 177945 14173 90436324
Petechiae 14.23 10.31 65 177885 15676 90434821
Lactic acidosis 14.22 10.31 51 177899 50412 90400085
Craniocervical syndrome 14.16 10.31 6 177944 104 90450393
Normal newborn 14.11 10.31 15 177935 23347 90427150
Pneumonia parainfluenzae viral 14.07 10.31 9 177941 375 90450122
Ulcer 14.03 10.31 27 177923 32855 90417642
Genital lesion 14.03 10.31 8 177942 270 90450227
Porphyria acute 14.00 10.31 9 177941 17966 90432531
Diverticulitis 13.99 10.31 143 177807 45044 90405453
Refractoriness to platelet transfusion 13.94 10.31 5 177945 54 90450443
Hypoalbuminaemia 13.90 10.31 65 177885 15832 90434665
Crystal nephropathy 13.79 10.31 14 177936 1137 90449360
Chronic hepatitis B 13.78 10.31 9 177941 389 90450108
Device issue 13.73 10.31 23 177927 29514 90420983
Nervousness 13.69 10.31 114 177836 33942 90416555
Model for end stage liver disease score increased 13.65 10.31 4 177946 21 90450476
Blood sodium decreased 13.65 10.31 97 177853 27516 90422981
Pneumonia respiratory syncytial viral 13.64 10.31 15 177935 1336 90449161
Transplant failure 13.55 10.31 18 177932 1951 90448546
Red blood cell abnormality 13.55 10.31 10 177940 527 90449970
Bronchiolitis obliterans syndrome 13.51 10.31 9 177941 402 90450095
CSF test abnormal 13.50 10.31 10 177940 530 90449967
Immature granulocyte count increased 13.50 10.31 10 177940 530 90449967
Breast cancer 13.44 10.31 57 177893 53704 90396793
B-cell lymphoma 13.42 10.31 25 177925 3621 90446876
Herpes zoster infection neurological 13.39 10.31 10 177940 537 90449960
Injection site phlebitis 13.33 10.31 6 177944 121 90450376
Feeling cold 13.30 10.31 96 177854 27369 90423128
Retinal depigmentation 13.24 10.31 8 177942 301 90450196
Human ehrlichiosis 13.24 10.31 7 177943 203 90450294
Tenosynovitis 13.23 10.31 6 177944 14561 90435936
Facial paralysis 13.20 10.31 63 177887 15471 90435026
Arterial occlusive disease 13.20 10.31 4 177946 12442 90438055
Chronic lymphocytic leukaemia transformation 13.18 10.31 5 177945 64 90450433
Sinus bradycardia 13.16 10.31 67 177883 16885 90433612
Right ventricular failure 13.16 10.31 11 177939 19194 90431303
Gastric dilatation 13.14 10.31 15 177935 1392 90449105
Loss of personal independence in daily activities 13.14 10.31 188 177762 135917 90314580
Enterococcal bacteraemia 13.14 10.31 18 177932 2010 90448487
Myelodysplastic syndrome 13.13 10.31 78 177872 20825 90429672
Arrhythmia 13.12 10.31 134 177816 42198 90408299
Middle ear effusion 13.09 10.31 21 177929 2700 90447797
Oedema mucosal 13.08 10.31 14 177936 1209 90449288
Panniculitis 13.07 10.31 6 177944 14452 90436045
Cytomegalovirus enterocolitis 13.06 10.31 12 177938 862 90449635
Peripheral coldness 13.04 10.31 58 177892 13834 90436663
Premature labour 12.97 10.31 5 177945 13371 90437126
Poor quality sleep 12.95 10.31 88 177862 24605 90425892
Tracheo-oesophageal fistula 12.90 10.31 11 177939 715 90449782
Central nervous system lymphoma 12.88 10.31 18 177932 2047 90448450
Swelling face 12.88 10.31 228 177722 81124 90369373
Intussusception 12.85 10.31 13 177937 1052 90449445
Failure to thrive 12.80 10.31 41 177909 8370 90442127
Mean platelet volume increased 12.79 10.31 12 177938 885 90449612
Infusion site extravasation 12.79 10.31 47 177903 10281 90440216
Ear pain 12.75 10.31 64 177886 57638 90392859
Injection site urticaria 12.74 10.31 10 177940 18001 90432496
Confusional state 12.72 10.31 624 177326 385581 90064916
Ophthalmic herpes zoster 12.71 10.31 21 177929 2767 90447730
Atypical pneumonia 12.68 10.31 30 177920 5134 90445363
Mycobacterium kansasii infection 12.65 10.31 6 177944 137 90450360
Myocardial infarction 12.61 10.31 140 177810 105832 90344665
Infrapatellar fat pad inflammation 12.61 10.31 7 177943 224 90450273
Ankylosing spondylitis 12.59 10.31 5 177945 13128 90437369
Epistaxis 12.57 10.31 236 177714 84889 90365608
Tardive dyskinesia 12.56 10.31 3 177947 10927 90439570
Pneumococcal sepsis 12.55 10.31 12 177938 906 90449591
Transfusion reaction 12.54 10.31 14 177936 1268 90449229
Anti-thyroid antibody 12.44 10.31 4 177946 30 90450467
Premature delivery 12.43 10.31 37 177913 38725 90411772
Newcastle disease 12.42 10.31 3 177947 6 90450491
Viral oesophagitis 12.42 10.31 3 177947 6 90450491
Viral haemorrhagic cystitis 12.42 10.31 15 177935 1478 90449019
Altered state of consciousness 12.38 10.31 105 177845 31427 90419070
Encephalitis brain stem 12.38 10.31 6 177944 144 90450353
Gastroenteritis norovirus 12.35 10.31 19 177931 2357 90448140
Blood pressure systolic abnormal 12.34 10.31 12 177938 19466 90431031
Chest pain 12.24 10.31 508 177442 319137 90131360
Cleft palate 12.24 10.31 14 177936 1302 90449195
Salmonella test positive 12.21 10.31 4 177946 32 90450465
Pulmonary infarction 12.14 10.31 21 177929 2871 90447626
Drug monitoring procedure not performed 12.14 10.31 11 177939 776 90449721
Protein total decreased 12.13 10.31 36 177914 7053 90443444
Angina pectoris 12.11 10.31 38 177912 39122 90411375
Drug-induced liver injury 12.11 10.31 116 177834 90202 90360295
Congenital syphilis 12.11 10.31 3 177947 7 90450490
Brain herniation 12.10 10.31 26 177924 4174 90446323
Tachycardia 12.10 10.31 400 177550 157273 90293224
Weight decreased 12.09 10.31 616 177334 379294 90071203
Hyperpyrexia 12.07 10.31 28 177922 4733 90445764
Injection site warmth 12.04 10.31 10 177940 17505 90432992
Coagulation test abnormal 11.98 10.31 12 177938 959 90449538
Pollakiuria 11.97 10.31 108 177842 32897 90417600
Adrenal mass 11.97 10.31 13 177937 1142 90449355
Metastases to lymph nodes 11.96 10.31 4 177946 11685 90438812
International normalised ratio increased 11.93 10.31 50 177900 47266 90403231
Micrococcus infection 11.84 10.31 5 177945 86 90450411
Genital rash 11.82 10.31 10 177940 643 90449854
Foetal death 11.76 10.31 14 177936 20709 90429788
JC virus infection 11.75 10.31 20 177930 2699 90447798
Gastritis haemorrhagic 11.70 10.31 16 177934 1784 90448713
Hepatitis 11.68 10.31 86 177864 70653 90379844
Thyroid cyst 11.65 10.31 10 177940 656 90449841
Dust allergy 11.65 10.31 11 177939 818 90449679
SARS-CoV-2 test positive 11.63 10.31 48 177902 11080 90439417
Multiple sclerosis 11.63 10.31 94 177856 27746 90422751
Protein total increased 11.62 10.31 23 177927 3486 90447011
Vibration test abnormal 11.61 10.31 4 177946 38 90450459
Infusion site discomfort 11.59 10.31 16 177934 1800 90448697
Limb discomfort 11.57 10.31 120 177830 37940 90412557
Lymphadenitis fungal 11.56 10.31 3 177947 9 90450488
Pancreatitis viral 11.56 10.31 3 177947 9 90450488
Personality disorder 11.50 10.31 5 177945 12439 90438058
West Nile viral infection 11.44 10.31 9 177941 522 90449975
Infusion site necrosis 11.43 10.31 5 177945 94 90450403
Drug dose omission by device 11.39 10.31 3 177947 10228 90440269
Eye infection viral 11.38 10.31 6 177944 173 90450324
Cough 11.33 10.31 856 177094 368106 90082391
Parainfluenzae virus infection 11.31 10.31 20 177930 2783 90447714
Menstrual disorder 11.30 10.31 32 177918 6106 90444391
Pneumonia cryptococcal 11.29 10.31 13 177937 1218 90449279
Bronchitis viral 11.25 10.31 13 177937 1222 90449275
Hepatitis B antibody positive 11.25 10.31 4 177946 42 90450455
Encephalitis toxic 11.25 10.31 4 177946 42 90450455
Oesophagitis 11.25 10.31 65 177885 17184 90433313
Bronchitis 11.24 10.31 386 177564 152541 90297956
Blood loss anaemia 11.23 10.31 3 177947 10137 90440360
Lung neoplasm malignant 11.19 10.31 19 177931 24254 90426243
Mitral valve disease 11.17 10.31 19 177931 2563 90447934
Gastrointestinal infection 11.17 10.31 47 177903 10943 90439554
Caesarean section 11.14 10.31 12 177938 18565 90431932
Respiratory tract infection viral 11.11 10.31 21 177929 3075 90447422
Peripheral T-cell lymphoma unspecified 11.11 10.31 7 177943 284 90450213
Colitis microscopic 11.11 10.31 4 177946 11155 90439342
Non-Hodgkin's lymphoma recurrent 11.11 10.31 3 177947 11 90450486
Urine bilirubin increased 11.09 10.31 4 177946 44 90450453
Dystonia 11.08 10.31 10 177940 16809 90433688
Blood calcium increased 11.06 10.31 50 177900 12008 90438489
Mean cell haemoglobin increased 11.05 10.31 24 177926 3881 90446616
Squamous cell carcinoma of skin 11.05 10.31 36 177914 7413 90443084
Acquired diaphragmatic eventration 11.05 10.31 9 177941 549 90449948
Pneumonia legionella 11.05 10.31 16 177934 1881 90448616
Tri-iodothyronine free abnormal 11.01 10.31 4 177946 45 90450452
Asthenia 11 10.31 1203 176747 532548 89917949
Flatulence 11.00 10.31 127 177823 41240 90409257
Device breakage 10.98 10.31 7 177943 14037 90436460
Teratoma 10.95 10.31 6 177944 187 90450310
Bilirubin urine 10.90 10.31 3 177947 12 90450485
Proctitis herpes 10.90 10.31 3 177947 12 90450485
Acute HIV infection 10.90 10.31 3 177947 12 90450485
Pupillary block 10.90 10.31 3 177947 12 90450485
Papillary serous endometrial carcinoma 10.90 10.31 3 177947 12 90450485
Eye injury 10.89 10.31 4 177946 11016 90439481
Circumoral swelling 10.85 10.31 4 177946 47 90450450
Red blood cell elliptocytes present 10.85 10.31 4 177946 47 90450450
Immature granulocyte percentage increased 10.77 10.31 4 177946 48 90450449
Biliary tract infection bacterial 10.77 10.31 4 177946 48 90450449
Vulval ulceration 10.72 10.31 8 177942 429 90450068
Primitive reflex test positive 10.71 10.31 3 177947 13 90450484
Thyroid function test abnormal 10.71 10.31 24 177926 3965 90446532
Colitis 10.71 10.31 195 177755 69747 90380750
Adverse event 10.70 10.31 164 177786 117254 90333243
Nodal arrhythmia 10.69 10.31 13 177937 1290 90449207
Nasal polyps 10.66 10.31 4 177946 10876 90439621
Enterocolitis haemorrhagic 10.66 10.31 15 177935 1717 90448780
Leukoencephalopathy 10.58 10.31 27 177923 4846 90445651
Microcytosis 10.56 10.31 6 177944 201 90450296
Parasitic encephalitis 10.56 10.31 4 177946 51 90450446
Tendonitis 10.54 10.31 16 177934 21356 90429141
Vulvovaginal injury 10.53 10.31 9 177941 587 90449910
Intention tremor 10.53 10.31 8 177942 441 90450056
Vitamin D decreased 10.49 10.31 49 177901 11930 90438567
Adenoviral hepatitis 10.48 10.31 8 177942 444 90450053
Affect lability 10.46 10.31 12 177938 18051 90432446
Nodule 10.46 10.31 23 177927 26663 90423834
Myoclonus 10.46 10.31 69 177881 19099 90431398
Streptococcal bacteraemia 10.46 10.31 17 177933 2210 90448287
Diabetic ketoacidosis 10.45 10.31 20 177930 24387 90426110
Viral upper respiratory tract infection 10.45 10.31 39 177911 8595 90441902
Disseminated cryptococcosis 10.42 10.31 10 177940 759 90449738
Speech disorder 10.41 10.31 136 177814 45449 90405048
Propofol infusion syndrome 10.41 10.31 13 177937 1326 90449171
Adjustment disorder 10.41 10.31 3 177947 9639 90440858
Exposure via skin contact 10.38 10.31 4 177946 10701 90439796
Breast cancer stage I 10.38 10.31 3 177947 9621 90440876
Pulmonary haemorrhage 10.37 10.31 37 177913 7976 90442521
Incorrect dose administered 10.32 10.31 102 177848 78828 90371669

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 1629.07 10.88 1376 156969 46202 42416788
White blood cell count decreased 595.06 10.88 1285 157060 109111 42353879
Pneumonia 592.97 10.88 3107 155238 419042 42043948
Cytokine release syndrome 539.60 10.88 743 157602 43784 42419206
Neuropathy peripheral 528.83 10.88 1168 157177 100685 42362305
Febrile neutropenia 505.51 10.88 1677 156668 184026 42278964
Platelet count decreased 499.84 10.88 1382 156963 137199 42325791
Neutropenia 420.26 10.88 1657 156688 197774 42265216
Full blood count decreased 370.94 10.88 419 157926 20141 42442849
Pyrexia 357.98 10.88 2594 155751 391448 42071542
Drug abuse 346.80 10.88 9 158336 104762 42358228
Neurotoxicity 288.38 10.88 396 157949 23255 42439735
Toxicity to various agents 287.60 10.88 257 158088 228879 42234111
Neutrophil count decreased 263.31 10.88 667 157678 62748 42400242
Completed suicide 256.81 10.88 29 158316 96436 42366554
Rash 255.26 10.88 1831 156514 275123 42187867
Graft versus host disease 229.02 10.88 261 158084 12664 42450326
Fatigue 208.42 10.88 2501 155844 433140 42029850
Thrombosis 193.23 10.88 627 157718 67884 42395106
Cytomegalovirus infection 187.50 10.88 388 157957 31918 42431072
Intentional product misuse 179.77 10.88 13 158332 61887 42401103
Laboratory test abnormal 177.90 10.88 312 158033 22666 42440324
Drug interaction 177.05 10.88 463 157882 266536 42196454
Thrombocytopenia 169.76 10.88 1249 157096 189030 42273960
Pancytopenia 162.77 10.88 865 157480 116878 42346112
Immune effector cell-associated neurotoxicity syndrome 147.59 10.88 179 158166 9282 42453708
Intentional overdose 135.58 10.88 16 158329 51440 42411550
Sepsis 127.81 10.88 1215 157130 198119 42264871
Adverse drug reaction 126.42 10.88 365 157980 37069 42425921
Injection site pain 125.79 10.88 30 158315 57768 42405222
Plasma cell myeloma recurrent 122.44 10.88 128 158217 5629 42457361
Septic shock 120.22 10.88 664 157681 91008 42371982
Diarrhoea 114.78 10.88 2372 155973 458477 42004513
Acute graft versus host disease 113.09 10.88 146 158199 8069 42454921
Overdose 112.69 10.88 135 158210 105129 42357861
Suicide attempt 106.27 10.88 21 158324 46079 42416911
Deep vein thrombosis 104.65 10.88 563 157782 76394 42386596
Meningoencephalitis herpetic 103.30 10.88 58 158287 976 42462014
Tooth disorder 101.05 10.88 169 158176 11810 42451180
Hypoglycaemia 100.87 10.88 48 158297 59806 42403184
Infection 99.98 10.88 736 157609 111332 42351658
Rheumatoid arthritis 98.53 10.88 19 158326 42421 42420569
Inappropriate schedule of product administration 98.45 10.88 127 158218 95775 42367215
Cytomegalovirus viraemia 97.88 10.88 154 158191 10223 42452767
Acute graft versus host disease in skin 97.62 10.88 129 158216 7295 42455695
Mucosal inflammation 90.79 10.88 394 157951 48980 42414010
Chronic graft versus host disease 90.75 10.88 112 158233 5913 42457077
Suicidal ideation 90.21 10.88 33 158312 48128 42414862
Encephalitis 89.29 10.88 138 158207 9020 42453970
Influenza 88.03 10.88 460 157885 61715 42401275
Constipation 87.53 10.88 955 157390 161336 42301654
Chronic lymphocytic leukaemia 86.36 10.88 98 158247 4731 42458259
Arthralgia 85.96 10.88 431 157914 204807 42258183
Bronchopulmonary aspergillosis 84.38 10.88 208 158137 19221 42443769
Muscle spasms 83.63 10.88 577 157768 85467 42377523
Therapeutic product effect incomplete 83.60 10.88 84 158261 70855 42392135
Herpes simplex 82.27 10.88 116 158229 6979 42456011
Acute graft versus host disease in intestine 80.74 10.88 86 158259 3865 42459125
Wrong technique in product usage process 80.21 10.88 29 158316 42606 42420384
Tumour lysis syndrome 80.16 10.88 222 158123 22009 42440981
Drug dependence 79.29 10.88 8 158337 29086 42433904
Asthma 77.86 10.88 70 158275 62244 42400746
Stress 76.76 10.88 34 158311 44178 42418812
Cytopenia 75.65 10.88 187 158158 17310 42445680
Plasmacytoma 75.40 10.88 87 158258 4277 42458713
Psoriasis 74.51 10.88 44 158301 48560 42414430
Lymphocyte count decreased 73.42 10.88 249 158096 27560 42435430
Post transplant lymphoproliferative disorder 73.40 10.88 126 158219 8994 42453996
Sedation 72.11 10.88 13 158332 30462 42432528
Anxiety 71.43 10.88 215 158130 118345 42344645
Encephalitis viral 71.08 10.88 53 158292 1475 42461515
International normalised ratio increased 70.52 10.88 46 158299 48122 42414868
Acute myeloid leukaemia 69.41 10.88 211 158134 22045 42440945
Light chain analysis increased 69.32 10.88 56 158289 1758 42461232
Herpes zoster 69.00 10.88 307 158038 38570 42424420
Red blood cell count decreased 67.92 10.88 271 158074 32444 42430546
Cystitis haemorrhagic 66.69 10.88 107 158238 7222 42455768
Cardiogenic shock 65.77 10.88 25 158320 35615 42427375
Somnolence 64.50 10.88 287 158058 140818 42322172
Toxic encephalopathy 63.93 10.88 102 158243 6851 42456139
COVID-19 pneumonia 62.86 10.88 200 158145 21413 42441577
Epstein-Barr virus infection 62.68 10.88 122 158223 9596 42453394
Cytomegalovirus test positive 61.40 10.88 78 158267 4241 42458749
Venoocclusive liver disease 61.24 10.88 125 158220 10177 42452813
Hyperkalaemia 60.76 10.88 130 158215 80328 42382662
Herpes virus infection 59.46 10.88 71 158274 3621 42459369
Encephalopathy 59.31 10.88 307 158038 41026 42421964
Psoriatic arthropathy 58.33 10.88 11 158334 24956 42438034
Drug resistance 58.20 10.88 267 158078 33981 42429009
Necrotising retinitis 57.71 10.88 40 158305 990 42462000
Pathogen resistance 56.68 10.88 129 158216 11321 42451669
Angioedema 56.39 10.88 45 158300 42432 42420558
Haematotoxicity 55.75 10.88 125 158220 10860 42452130
Blood pressure increased 55.71 10.88 193 158152 101735 42361255
Ageusia 54.42 10.88 128 158217 11477 42451513
COVID-19 54.26 10.88 664 157681 115284 42347706
Rhabdomyolysis 54.10 10.88 132 158213 77887 42385103
Antiviral drug level above therapeutic 54.08 10.88 17 158328 54 42462936
Body height decreased 53.53 10.88 71 158274 4029 42458961
Foetal exposure during pregnancy 53.51 10.88 58 158287 47253 42415737
Bradycardia 52.93 10.88 153 158192 85331 42377659
Acute myeloid leukaemia recurrent 52.43 10.88 65 158280 3447 42459543
Dyspnoea 52.11 10.88 1250 157095 441371 42021619
Pneumonia fungal 52.05 10.88 109 158236 9037 42453953
Human herpesvirus 6 infection 51.66 10.88 55 158290 2470 42460520
Acute kidney injury 50.36 10.88 1750 156595 365587 42097403
Neutropenic sepsis 49.55 10.88 151 158194 15795 42447195
Renal disorder 49.29 10.88 226 158119 28754 42434236
Myocardial infarction 49.28 10.88 265 158080 123744 42339246
Colitis ulcerative 48.90 10.88 18 158327 26157 42436833
Drug hypersensitivity 48.57 10.88 197 158148 99192 42363798
Incorrect route of product administration 48.39 10.88 15 158330 24290 42438700
Enterococcal infection 48.22 10.88 125 158220 11914 42451076
Ophthalmic herpes simplex 48.14 10.88 25 158320 357 42462633
Cytomegalovirus infection reactivation 47.83 10.88 119 158226 11059 42451931
Blood pressure systolic increased 47.77 10.88 22 158323 27946 42435044
Depression 47.05 10.88 233 158112 111130 42351860
Multiple organ dysfunction syndrome 46.83 10.88 559 157786 96476 42366514
Blood pressure fluctuation 46.22 10.88 21 158324 26887 42436103
Haemophagocytic lymphohistiocytosis 46.21 10.88 161 158184 18061 42444929
Adenovirus infection 45.78 10.88 87 158258 6722 42456268
Nightmare 45.40 10.88 18 158327 24994 42437996
Lactic acidosis 45.33 10.88 61 158284 45200 42417790
Hyperbilirubinaemia 45.31 10.88 174 158171 20461 42442529
Haematochezia 45.31 10.88 93 158252 58343 42404647
Acute lymphocytic leukaemia recurrent 45.27 10.88 62 158283 3629 42459361
Taste disorder 45.09 10.88 110 158235 10097 42452893
Cardio-respiratory arrest 44.89 10.88 94 158251 58542 42404448
Obstructive airways disorder 44.64 10.88 18 158327 24741 42438249
Thrombotic microangiopathy 44.10 10.88 138 158207 14644 42448346
Varicella zoster virus infection 43.51 10.88 51 158294 2550 42460440
Contraindicated product administered 42.98 10.88 20 158325 25252 42437738
IVth nerve paralysis 42.95 10.88 27 158318 564 42462426
Wheezing 42.63 10.88 87 158258 54694 42408296
Venoocclusive disease 42.45 10.88 62 158283 3853 42459137
Ventricular fibrillation 42.44 10.88 30 158315 30093 42432897
Nephropathy toxic 42.03 10.88 148 158197 16690 42446300
Unevaluable event 42.02 10.88 244 158101 34044 42428946
Graft versus host disease in skin 41.93 10.88 72 158273 5140 42457850
Organic brain syndrome 41.89 10.88 22 158323 322 42462668
Parainfluenzae virus infection 41.41 10.88 59 158286 3584 42459406
Pneumonia cytomegaloviral 41.38 10.88 63 158282 4063 42458927
Stem cell transplant 40.77 10.88 50 158295 2622 42460368
Renal failure 40.64 10.88 755 157590 142971 42320019
Treatment noncompliance 40.62 10.88 48 158297 37624 42425366
Interstitial lung disease 40.59 10.88 152 158193 78310 42384680
Rash pruritic 40.45 10.88 238 158107 33365 42429625
Bacterial sepsis 40.14 10.88 80 158265 6402 42456588
Drug withdrawal syndrome 39.95 10.88 15 158330 21534 42441456
Abdominal pain 39.95 10.88 484 157861 189987 42273003
Fungal infection 39.83 10.88 162 158183 19560 42443430
Loss of personal independence in daily activities 39.72 10.88 78 158267 49738 42413252
Sleep disorder 39.48 10.88 74 158271 48021 42414969
Cardiac arrest 39.45 10.88 241 158104 109079 42353911
Intentional self-injury 39.36 10.88 5 158340 15197 42447793
Corynebacterium bacteraemia 39.23 10.88 16 158329 125 42462865
Aggression 38.92 10.88 65 158280 44098 42418892
Therapeutic response shortened 38.90 10.88 3 158342 13551 42449439
Brain stem stroke 38.78 10.88 21 158324 328 42462662
Diffuse large B-cell lymphoma 38.73 10.88 99 158246 9355 42453635
Cystitis viral 38.52 10.88 34 158311 1208 42461782
Crystal urine present 38.50 10.88 23 158322 437 42462553
Rectal haemorrhage 38.41 10.88 79 158266 49527 42413463
Vomiting 38.33 10.88 803 157542 288920 42174070
Gastrointestinal haemorrhage 38.17 10.88 210 158135 97516 42365474
Full blood count increased 38.16 10.88 31 158314 981 42462009
Pulmonary thrombosis 37.98 10.88 91 158254 8257 42454733
Respiratory arrest 37.86 10.88 30 158315 28394 42434596
Enterococcal bacteraemia 37.65 10.88 48 158297 2619 42460371
Blood creatine phosphokinase increased 37.41 10.88 77 158268 48261 42414729
Drug ineffective 37.06 10.88 1940 156405 628257 41834733
Respiratory depression 36.93 10.88 12 158333 18856 42444134
Musculoskeletal stiffness 36.78 10.88 102 158243 57663 42405327
Mantle cell lymphoma 36.74 10.88 36 158309 1464 42461526
Arteriosclerosis coronary artery 36.34 10.88 12 158333 18665 42444325
Fusarium infection 36.29 10.88 37 158308 1579 42461411
Synovitis 36.06 10.88 7 158338 15560 42447430
Mucormycosis 35.93 10.88 81 158264 7062 42455928
Protein total increased 35.77 10.88 46 158299 2532 42460458
Lymphocyte percentage decreased 35.65 10.88 43 158302 2216 42460774
Candida infection 35.62 10.88 167 158178 21443 42441547
Cellulitis enterococcal 35.52 10.88 14 158331 99 42462891
Intentional product use issue 35.33 10.88 142 158203 71691 42391299
Graft versus host disease in gastrointestinal tract 34.93 10.88 66 158279 5077 42457913
Condition aggravated 34.69 10.88 722 157623 260032 42202958
Toxoplasmosis 34.66 10.88 36 158309 1571 42461419
General physical health deterioration 34.56 10.88 377 157968 150869 42312121
Blood bilirubin increased 34.54 10.88 272 158073 41980 42421010
Therapeutic product effect decreased 34.15 10.88 58 158287 39092 42423898
Glycosylated haemoglobin increased 34.08 10.88 4 158341 12920 42450070
Malignant neoplasm progression 34.08 10.88 249 158096 108151 42354839
Anaphylactic reaction 34.01 10.88 67 158278 42676 42420314
Atrial fibrillation 33.99 10.88 717 157628 138876 42324114
Acute myocardial infarction 33.92 10.88 107 158238 58058 42404932
Monoclonal immunoglobulin increased 33.90 10.88 21 158324 427 42462563
Bacteraemia 33.87 10.88 183 158162 24857 42438133
Prostate cancer 33.80 10.88 72 158273 44571 42418419
Anaphylactic shock 33.69 10.88 23 158322 23494 42439496
Seasonal allergy 33.67 10.88 85 158260 7970 42455020
Monoclonal immunoglobulin present 33.67 10.88 31 158314 1165 42461825
Device issue 33.66 10.88 5 158340 13504 42449486
Engraft failure 33.51 10.88 23 158322 560 42462430
Neutropenic infection 33.47 10.88 38 158307 1835 42461155
Pain in extremity 33.38 10.88 378 157967 150226 42312764
Accidental exposure to product 33.37 10.88 17 158328 20376 42442614
Oxygen saturation decreased 33.01 10.88 126 158219 64561 42398429
Palpitations 32.86 10.88 89 158256 50708 42412282
Hypogammaglobulinaemia 32.73 10.88 108 158237 11783 42451207
Crystalluria 32.64 10.88 25 158320 725 42462265
Device malfunction 32.05 10.88 4 158341 12323 42450667
Neutrophil percentage increased 31.99 10.88 38 158307 1927 42461063
Pseudomonal sepsis 31.98 10.88 57 158288 4192 42458798
Neutrophil count abnormal 31.68 10.88 45 158300 2726 42460264
Impaired work ability 31.25 10.88 4 158341 12087 42450903
Miosis 31.24 10.88 6 158339 13440 42449550
Electrocardiogram QT prolonged 31.01 10.88 84 158261 47861 42415129
Systemic candida 30.98 10.88 64 158281 5255 42457735
Clostridium difficile infection 30.92 10.88 166 158179 22493 42440497
Neuroleptic malignant syndrome 30.76 10.88 21 158324 21451 42441539
Underdose 30.23 10.88 12 158333 16654 42446336
Urine analysis abnormal 30.21 10.88 39 158306 2155 42460835
Pulmonary fibrosis 29.84 10.88 33 158312 26648 42436342
Metastases to bone 29.73 10.88 9 158336 14800 42448190
Engraftment syndrome 29.73 10.88 31 158314 1359 42461631
Pre-engraftment immune reaction 29.47 10.88 14 158331 163 42462827
Diabetic ketoacidosis 29.30 10.88 24 158321 22343 42440647
Arthritis 29.29 10.88 71 158274 41994 42420996
Frequent bowel movements 29.27 10.88 22 158323 21385 42441605
Pneumonia viral 29.21 10.88 55 158290 4219 42458771
Dystonia 29.11 10.88 6 158339 12784 42450206
Fibrin D dimer increased 29.06 10.88 60 158285 4925 42458065
Melaena 28.91 10.88 63 158282 38683 42424307
Acute graft versus host disease in liver 28.85 10.88 36 158309 1922 42461068
Febrile infection 28.77 10.88 43 158302 2728 42460262
Labelled drug-drug interaction medication error 28.63 10.88 11 158334 15571 42447419
Spinal fracture 28.53 10.88 87 158258 9103 42453887
Body temperature decreased 28.50 10.88 9 158336 14404 42448586
Schizophrenia 28.49 10.88 3 158342 10547 42452443
Blood lactate dehydrogenase increased 28.40 10.88 180 158165 25901 42437089
Coma 28.18 10.88 103 158242 53451 42409539
Toxic epidermal necrolysis 28.13 10.88 183 158162 26567 42436423
Urine abnormality 28.05 10.88 38 158307 2201 42460789
Obesity 28.03 10.88 13 158332 16446 42446544
Coronary artery disease 27.82 10.88 104 158241 53616 42409374
Device leakage 27.58 10.88 3 158342 10282 42452708
Peripheral swelling 27.54 10.88 480 157865 89790 42373200
Swollen tongue 27.54 10.88 23 158322 21208 42441782
Herpes ophthalmic 27.39 10.88 22 158323 685 42462305
Paranoia 27.31 10.88 9 158336 14017 42448973
Chronic obstructive pulmonary disease 27.25 10.88 131 158214 62983 42400007
Pneumonia respiratory syncytial viral 27.18 10.88 30 158315 1404 42461586
Plasma cell leukaemia 27.14 10.88 28 158317 1212 42461778
Myasthenia gravis 27.09 10.88 13 158332 16124 42446866
Bronchiectasis 26.65 10.88 17 158328 18002 42444988
Eczema 26.63 10.88 54 158291 34032 42428958
Specific gravity urine increased 26.18 10.88 13 158332 168 42462822
Chest pain 26.12 10.88 363 157982 139167 42323823
Hyperhidrosis 26.06 10.88 213 158132 90299 42372691
Treatment failure 25.88 10.88 132 158213 62492 42400498
Aspartate aminotransferase 25.62 10.88 12 158333 135 42462855
Emotional distress 25.47 10.88 14 158331 16079 42446911
Hiccups 25.40 10.88 101 158244 12070 42450920
Metabolic acidosis 25.19 10.88 103 158242 51755 42411235
Varicella virus test positive 25.18 10.88 14 158331 231 42462759
Loss of consciousness 24.94 10.88 221 158124 92133 42370857
Hypertension 24.93 10.88 454 157891 166750 42296240
Diabetes mellitus inadequate control 24.93 10.88 13 158332 15377 42447613
Sinusitis 24.84 10.88 277 158068 47015 42415975
Myoclonic dystonia 24.64 10.88 10 158335 77 42462913
Bone pain 24.55 10.88 162 158183 23630 42439360
Tooth deposit 24.42 10.88 10 158335 79 42462911
Mucosal disorder 24.40 10.88 35 158310 2139 42460851
Oroantral fistula 24.35 10.88 13 158332 197 42462793
Mobility decreased 24.26 10.88 60 158285 35246 42427744
Blood immunoglobulin G decreased 24.16 10.88 36 158309 2278 42460712
C-reactive protein abnormal 24.09 10.88 3 158342 9258 42453732
Headache 24.09 10.88 691 157654 238678 42224312
Neutrophil Pelger-Huet anomaly present 24.00 10.88 14 158331 254 42462736
Cytomegalovirus chorioretinitis 23.99 10.88 53 158292 4558 42458432
Medication error 23.84 10.88 55 158290 33099 42429891
Injection site haemorrhage 23.80 10.88 7 158338 11729 42451261
Injection site swelling 23.78 10.88 17 158328 16956 42446034
Lower respiratory tract infection fungal 23.75 10.88 19 158326 588 42462402
Leukaemia recurrent 23.75 10.88 32 158313 1844 42461146
Pain 23.59 10.88 711 157634 244137 42218853
Immunodeficiency 23.56 10.88 70 158275 7220 42455770
Anti-platelet antibody positive 23.48 10.88 14 158331 265 42462725
Immune system disorder 23.43 10.88 62 158283 5982 42457008
Incorrect dose administered 23.43 10.88 109 158236 52865 42410125
Monocyte percentage increased 23.41 10.88 24 158321 1031 42461959
Withdrawal syndrome 23.17 10.88 13 158332 14762 42448228
Chest discomfort 23.06 10.88 140 158205 63476 42399514
Muscle rigidity 23.02 10.88 8 158337 12051 42450939
Chills 22.83 10.88 483 157862 93583 42369407
Lactose intolerance 22.69 10.88 28 158317 1478 42461512
Knee arthroplasty 22.47 10.88 3 158342 8778 42454212
Hepatic cirrhosis 22.44 10.88 24 158321 19678 42443312
Product quality issue 22.43 10.88 20 158325 17862 42445128
Bone marrow transplant 22.41 10.88 25 158320 1184 42461806
Myalgia 22.12 10.88 239 158106 95841 42367149
Troponin increased 21.96 10.88 23 158322 19039 42443951
Depressed mood 21.94 10.88 33 158312 23351 42439639
Injection site mass 21.77 10.88 3 158342 8572 42454418
Meningitis candida 21.63 10.88 11 158334 150 42462840
Hyperlipidaemia 21.54 10.88 29 158316 21487 42441503
Impaired quality of life 21.49 10.88 13 158332 14164 42448826
Drug intolerance 21.47 10.88 193 158152 80231 42382759
Squamous cell carcinoma of skin 21.45 10.88 99 158246 12627 42450363
CNS ventriculitis 21.44 10.88 15 158330 377 42462613
Fear 21.41 10.88 7 158338 10958 42452032
Staphylococcal bacteraemia 21.39 10.88 90 158255 11031 42451959
Psychotic disorder 21.37 10.88 48 158297 29160 42433830
Congenital herpes simplex infection 21.23 10.88 7 158338 27 42462963
Ischaemic stroke 21.23 10.88 31 158314 22202 42440788
Death 21.16 10.88 2028 156317 469157 41993833
Oesophageal carcinoma 21.15 10.88 5 158340 9691 42453299
Haemoptysis 21.01 10.88 94 158251 46073 42416917
Hypothyroidism 20.91 10.88 56 158289 32028 42430962
Hyponatraemia 20.80 10.88 259 158086 101203 42361787
Metastases to liver 20.79 10.88 18 158327 16308 42446682
Phlebitis infective 20.79 10.88 10 158335 120 42462870
Sleep apnoea syndrome 20.76 10.88 30 158315 21578 42441412
Epstein-Barr virus infection reactivation 20.75 10.88 36 158309 2591 42460399
Multiple allergies 20.71 10.88 44 158301 3684 42459306
Blood phosphorus decreased 20.65 10.88 43 158302 3550 42459440
Systemic mycosis 20.56 10.88 34 158311 2353 42460637
Stevens-Johnson syndrome 20.51 10.88 147 158198 22031 42440959
Diaphragmatic injury 20.36 10.88 10 158335 126 42462864
Upper respiratory tract infection 20.35 10.88 243 158102 41930 42421060
Adenomatous polyposis coli 20.25 10.88 11 158334 173 42462817
Product storage error 20.24 10.88 8 158337 11132 42451858
Enterococcal sepsis 20.20 10.88 31 158314 2013 42460977
Nervous system disorder 20.18 10.88 121 158224 17074 42445916
Sleep disorder due to a general medical condition 20.17 10.88 21 158324 17432 42445558
Cytomegalovirus oesophagitis 20.14 10.88 17 158328 568 42462422
Respiratory symptom 20.14 10.88 8 158337 11098 42451892
Mania 20.13 10.88 7 158338 10540 42452450
Acute respiratory failure 20.13 10.88 227 158118 38631 42424359
Pneumonia influenzal 20.12 10.88 30 158315 1899 42461091
Plateletcrit decreased 20.12 10.88 7 158338 33 42462957
Accessory spleen 20.08 10.88 10 158335 130 42462860
Needle issue 20.06 10.88 4 158341 8723 42454267
Epstein-Barr virus associated lymphoproliferative disorder 19.98 10.88 34 158311 2409 42460581
Red blood cell sedimentation rate increased 19.98 10.88 6 158339 9918 42453072
Product use in unapproved indication 19.96 10.88 527 157818 183929 42279061
Hepatic encephalopathy 19.90 10.88 19 158326 16423 42446567
Ulcer 19.90 10.88 19 158326 16422 42446568
Aplastic anaemia 19.90 10.88 95 158250 12289 42450701
Cyanosis 19.85 10.88 16 158329 15015 42447975
Stenotrophomonas infection 19.76 10.88 43 158302 3661 42459329
Salivary hypersecretion 19.65 10.88 8 158337 10935 42452055
Coronary artery stenosis 19.62 10.88 7 158338 10372 42452618
Aspergillus infection 19.59 10.88 113 158232 15724 42447266
Back disorder 19.58 10.88 67 158278 7447 42455543
Metastases to central nervous system 19.55 10.88 7 158338 10348 42452642
Urine leukocyte esterase positive 19.47 10.88 15 158330 439 42462551
Lymphopenia 19.41 10.88 142 158203 21421 42441569
Ventricular tachycardia 19.38 10.88 53 158292 30107 42432883
Blood potassium decreased 19.37 10.88 136 158209 20248 42442742
Graft versus host disease in liver 19.30 10.88 27 158318 1612 42461378
Acute generalised exanthematous pustulosis 19.30 10.88 73 158272 8522 42454468
Listeriosis 19.30 10.88 25 158320 1386 42461604
Cardiac failure congestive 19.28 10.88 214 158131 85388 42377602
Light chain analysis decreased 19.16 10.88 7 158338 39 42462951
Product substitution issue 19.10 10.88 9 158336 11281 42451709
Vitamin B12 decreased 19.06 10.88 27 158318 1631 42461359
Platelet count abnormal 19.05 10.88 42 158303 3607 42459383
Haematuria 19.02 10.88 131 158214 57668 42405322
Therapeutic response decreased 18.94 10.88 72 158273 36940 42426050
Diabetes mellitus 18.88 10.88 138 158207 59949 42403041
Discomfort 18.82 10.88 41 158304 25178 42437812
Weight increased 18.77 10.88 285 158060 107698 42355292
Clostridium difficile colitis 18.59 10.88 139 158206 21113 42441877
Disseminated toxoplasmosis 18.58 10.88 12 158333 263 42462727
Fungaemia 18.58 10.88 38 158307 3098 42459892
Acute lymphocytic leukaemia 18.49 10.88 40 158305 3391 42459599
White blood cell count abnormal 18.47 10.88 42 158303 3683 42459307
Alcohol poisoning 18.43 10.88 3 158342 7571 42455419
Herpes zoster meningitis 18.26 10.88 8 158337 76 42462914
Product prescribing error 18.23 10.88 44 158301 26068 42436922
Ecthyma 18.20 10.88 17 158328 651 42462339
Angina pectoris 18.15 10.88 62 158283 32834 42430156
Therapy cessation 18.11 10.88 30 158315 20420 42442570
Bladder cancer 18.08 10.88 22 158323 17025 42445965
NPM1 gene mutation 18.08 10.88 9 158336 117 42462873
Accidental overdose 18.04 10.88 50 158295 28280 42434710
Metastases to lung 17.99 10.88 10 158335 11414 42451576
Blood immunoglobulin A increased 17.93 10.88 14 158331 418 42462572
Autoimmune haemolytic anaemia 17.90 10.88 54 158291 5617 42457373
Herpes simplex viraemia 17.87 10.88 9 158336 120 42462870
Embolism 17.71 10.88 72 158273 8691 42454299
Reticulocytosis 17.63 10.88 12 158333 288 42462702
Cardiac murmur 17.63 10.88 13 158332 12762 42450228
Extrapyramidal disorder 17.59 10.88 21 158324 16391 42446599
Corneal deposits 17.53 10.88 11 158334 229 42462761
Nasopharyngitis 17.46 10.88 422 157923 83574 42379416
Anaemia 17.46 10.88 1237 157108 279041 42183949
Atrial septal defect 17.44 10.88 4 158341 7915 42455075
No adverse event 17.42 10.88 80 158265 38941 42424049
Pancreatitis 17.42 10.88 92 158253 43176 42419814
Gastric disorder 17.41 10.88 89 158256 11833 42451157
Type 2 diabetes mellitus 17.40 10.88 26 158319 18445 42444545
Meningitis cryptococcal 17.38 10.88 38 158307 3245 42459745
Malaise 17.36 10.88 629 157716 211527 42251463
Gingivitis ulcerative 17.36 10.88 11 158334 233 42462757
Strongyloidiasis 17.36 10.88 39 158306 3392 42459598
Respiratory failure 17.35 10.88 610 157735 127522 42335468
Streptococcal bacteraemia 17.34 10.88 34 158311 2688 42460302
Middle insomnia 17.17 10.88 4 158341 7829 42455161
Bone lesion 17.10 10.88 39 158306 3427 42459563
Breath sounds abnormal 17.09 10.88 12 158333 12081 42450909
Gynaecomastia 17.07 10.88 13 158332 12554 42450436
Bone marrow failure 16.99 10.88 193 158152 32900 42430090
Productive cough 16.90 10.88 117 158228 51450 42411540
Myelosuppression 16.87 10.88 85 158260 40376 42422614
Injection site bruising 16.87 10.88 11 158334 11514 42451476
Pneumocystis jirovecii pneumonia 16.83 10.88 155 158190 25026 42437964
Platelet distribution width decreased 16.80 10.88 6 158339 31 42462959
IgA nephropathy 16.79 10.88 31 158314 2343 42460647
Prostatic specific antigen increased 16.75 10.88 23 158322 16902 42446088
Dyslipidaemia 16.73 10.88 7 158338 9411 42453579
Pneumaturia 16.71 10.88 7 158338 59 42462931
Tumour flare 16.67 10.88 21 158324 1132 42461858
Joint injury 16.58 10.88 18 158327 14658 42448332
Haemoglobin decreased 16.56 10.88 625 157720 131846 42331144
Congenital pneumonia 16.56 10.88 8 158337 97 42462893
Surgery 16.39 10.88 25 158320 17591 42445399
Pleocytosis 16.36 10.88 16 158329 649 42462341
Plasma cell myeloma refractory 16.27 10.88 23 158322 1387 42461603
Pallor 16.24 10.88 54 158291 28832 42434158
Device related sepsis 16.23 10.88 41 158304 3846 42459144
Red blood cells urine positive 16.18 10.88 27 158318 1883 42461107
Pseudomonas infection 16.17 10.88 108 158237 15815 42447175
Blood pressure decreased 16.00 10.88 139 158206 58193 42404797
Gastrooesophageal reflux disease 15.84 10.88 100 158245 44923 42418067
Haemolytic uraemic syndrome 15.84 10.88 31 158314 2448 42460542
Light chain disease 15.79 10.88 9 158336 156 42462834
Sputum discoloured 15.77 10.88 9 158336 10123 42452867
Hypoaesthesia 15.76 10.88 362 157983 71101 42391889
Hypouricaemia 15.70 10.88 11 158334 277 42462713
Staphylococcal infection 15.65 10.88 211 158134 37432 42425558
Neutrophil percentage decreased 15.61 10.88 12 158333 350 42462640
Pancreatic carcinoma 15.44 10.88 8 158337 9498 42453492
Immunodeficiency common variable 15.43 10.88 11 158334 285 42462705
Hordeolum 15.42 10.88 24 158321 1578 42461412
Pathological fracture 15.41 10.88 49 158296 5244 42457746
Mesangioproliferative glomerulonephritis 15.40 10.88 9 158336 164 42462826
Weight decreased 15.37 10.88 624 157721 207324 42255666
Arteriosclerosis 15.37 10.88 27 158318 17962 42445028
Dyspnoea exertional 15.36 10.88 116 158229 50032 42412958
Meningoencephalitis bacterial 15.35 10.88 9 158336 165 42462825
Flushing 15.32 10.88 78 158267 36950 42426040
Injury 15.27 10.88 38 158307 22278 42440712
Follicular mucinosis 15.22 10.88 5 158340 19 42462971
Encephalitis brain stem 15.16 10.88 9 158336 169 42462821
Blood glucose increased 15.15 10.88 188 158157 73511 42389479
Atrioventricular block complete 15.13 10.88 12 158333 11352 42451638
Road traffic accident 15.12 10.88 30 158315 19063 42443927
Asphyxia 15.09 10.88 6 158339 8320 42454670
Heart rate decreased 15.09 10.88 77 158268 36455 42426535
Achromobacter infection 15.07 10.88 9 158336 171 42462819
CSF cell count increased 15.04 10.88 6 158339 44 42462946
Enamel anomaly 15.03 10.88 10 158335 231 42462759
Appendicitis 14.98 10.88 34 158311 20579 42442411
Bronchiolitis obliterans syndrome 14.94 10.88 11 158334 300 42462690
Joint swelling 14.94 10.88 171 158174 67851 42395139
Injection site erythema 14.93 10.88 33 158312 20162 42442828
Palmar-plantar erythrodysaesthesia syndrome 14.92 10.88 34 158311 20548 42442442
Myocarditis 14.79 10.88 30 158315 18908 42444082
Escherichia sepsis 14.76 10.88 51 158294 5696 42457294
Hospitalisation 14.76 10.88 191 158154 74139 42388851
Human polyomavirus infection 14.66 10.88 21 158324 1282 42461708
Blood loss anaemia 14.65 10.88 9 158336 9727 42453263
Premature baby 14.64 10.88 41 158304 23112 42439878
Respiratory syncytial virus infection 14.64 10.88 59 158286 7093 42455897
Migraine 14.64 10.88 47 158298 25367 42437623
Pulpitis dental 14.58 10.88 16 158329 744 42462246
Poisoning 14.52 10.88 20 158325 14679 42448311
Haemophilus sepsis 14.51 10.88 10 158335 245 42462745
Campylobacter gastroenteritis 14.49 10.88 19 158326 1066 42461924
Cardiomegaly 14.47 10.88 25 158320 16741 42446249
Oral herpes 14.47 10.88 61 158284 7483 42455507
White blood cells urine positive 14.45 10.88 22 158323 1419 42461571
Protein total abnormal 14.42 10.88 12 158333 393 42462597
Chimerism 14.41 10.88 10 158335 248 42462742
Respiratory acidosis 14.34 10.88 3 158342 6328 42456662
Tooth hypoplasia 14.34 10.88 10 158335 250 42462740
Iron deficiency 14.33 10.88 12 158333 11049 42451941
Gait disturbance 14.31 10.88 267 158078 97733 42365257
Aplasia 14.25 10.88 45 158300 4798 42458192
Poikiloderma 14.19 10.88 11 158334 325 42462665
Normochromic normocytic anaemia 14.09 10.88 8 158337 9023 42453967
Atrial flutter 14.06 10.88 111 158234 17140 42445850
Haematoma 14.02 10.88 55 158290 27968 42435022
Eosinophil percentage increased 14.01 10.88 14 158331 583 42462407
Philadelphia positive acute lymphocytic leukaemia 13.98 10.88 6 158339 54 42462936
Amyloidosis 13.96 10.88 29 158316 2390 42460600
Musculoskeletal pain 13.93 10.88 70 158275 33270 42429720
Ascites 13.85 10.88 139 158206 56539 42406451
CSF lactate increased 13.80 10.88 3 158342 0 42462990
Mononuclear cell count increased 13.80 10.88 3 158342 0 42462990
Encephalitis autoimmune 13.77 10.88 21 158324 1356 42461634
Hypopnoea 13.77 10.88 6 158339 7876 42455114
Cataract 13.75 10.88 174 158171 30430 42432560
West Nile viral infection 13.73 10.88 17 158328 900 42462090
Hyperthyroidism 13.69 10.88 20 158325 14321 42448669
Bronchitis 13.68 10.88 249 158096 46952 42416038
Renal oncocytoma 13.67 10.88 9 158336 204 42462786
Proteus infection 13.62 10.88 21 158324 1369 42461621
Oesophagopleural fistula 13.61 10.88 6 158339 58 42462932
Product administration error 13.54 10.88 30 158315 18313 42444677
Meningitis aseptic 13.51 10.88 42 158303 4440 42458550
Band neutrophil percentage increased 13.48 10.88 7 158338 100 42462890
Activated partial thromboplastin time prolonged 13.47 10.88 24 158321 15879 42447111
Blood phosphorus increased 13.45 10.88 16 158329 12509 42450481
Aspiration 13.41 10.88 29 158316 17857 42445133
T-lymphocyte count decreased 13.39 10.88 10 158335 279 42462711
Gastric ulcer 13.37 10.88 30 158315 18232 42444758
Neutrophil count increased 13.33 10.88 34 158311 19770 42443220
Congestive cardiomyopathy 13.33 10.88 8 158337 8756 42454234
Sideroblastic anaemia 13.33 10.88 11 158334 356 42462634
CSF protein increased 13.32 10.88 16 158329 821 42462169
Pulmonary hypertension 13.29 10.88 44 158301 23525 42439465
Pulmonary arterial hypertension 13.26 10.88 11 158334 10176 42452814
Retinitis viral 13.25 10.88 8 158337 155 42462835
Catarrh 13.23 10.88 3 158342 5983 42457007
Cerebral toxoplasmosis 13.12 10.88 26 158319 2072 42460918
Bacillus infection 13.10 10.88 15 158330 731 42462259
Panic attack 13.09 10.88 13 158332 11032 42451958
Splenic embolism 13.09 10.88 10 158335 289 42462701
Ischaemic cardiomyopathy 13.03 10.88 4 158341 6518 42456472
Pemphigoid 13.03 10.88 14 158331 11453 42451537
Upper gastrointestinal haemorrhage 13.01 10.88 63 158282 30236 42432754
Neuralgic amyotrophy 13.00 10.88 10 158335 292 42462698
Neuromyotonia 12.98 10.88 5 158340 33 42462957
Bacterial test 12.94 10.88 8 158337 162 42462828
Herpes simplex encephalitis 12.90 10.88 11 158334 373 42462617
Rash vesicular 12.86 10.88 34 158311 3279 42459711
Dermatitis allergic 12.86 10.88 64 158281 8419 42454571
Gingival oedema 12.85 10.88 5 158340 34 42462956
Viral haemorrhagic cystitis 12.85 10.88 24 158321 1830 42461160
Haematemesis 12.85 10.88 63 158282 30136 42432854
Vitamin B1 decreased 12.82 10.88 11 158334 376 42462614
Osteoarthritis 12.79 10.88 47 158298 24358 42438632
Serotonin syndrome 12.76 10.88 51 158294 25794 42437196
Rash maculo-papular 12.74 10.88 203 158142 37300 42425690
Electrocardiogram QRS complex prolonged 12.71 10.88 3 158342 5820 42457170
Sinusitis fungal 12.70 10.88 15 158330 756 42462234
Blood pressure diastolic increased 12.66 10.88 4 158341 6401 42456589
Low birth weight baby 12.65 10.88 11 158334 9944 42453046
Escherichia bacteraemia 12.63 10.88 45 158300 5104 42457886
Geotrichum infection 12.58 10.88 13 158332 564 42462426
Disseminated varicella zoster virus infection 12.54 10.88 15 158330 766 42462224
Hyperphosphataemia 12.54 10.88 18 158327 12986 42450004
Bilirubin urine present 12.52 10.88 8 158337 172 42462818
pH urine increased 12.47 10.88 6 158339 72 42462918
Device occlusion 12.46 10.88 8 158337 8442 42454548
Mean platelet volume decreased 12.43 10.88 14 158331 670 42462320
Idiopathic pneumonia syndrome 12.43 10.88 12 158333 479 42462511
Hyperpyrexia 12.41 10.88 35 158310 3505 42459485
Emotional disorder 12.38 10.88 4 158341 6310 42456680
Fistula 12.35 10.88 7 158338 7905 42455085
Myocardial ischaemia 12.34 10.88 30 158315 17732 42445258
Catheter site infection 12.33 10.88 32 158313 3051 42459939
Transplant failure 12.29 10.88 38 158307 4006 42458984
Peripheral arterial occlusive disease 12.28 10.88 5 158340 6833 42456157
Hepatosplenomegaly neonatal 12.27 10.88 5 158340 39 42462951
Dysbiosis 12.24 10.88 15 158330 786 42462204
Altered state of consciousness 12.16 10.88 164 158181 29095 42433895
Aspergillus test positive 12.15 10.88 14 158331 687 42462303
Tricuspid valve incompetence 12.15 10.88 14 158331 11099 42451891
Device dislocation 12.12 10.88 7 158338 7824 42455166
Anal fistula 12.07 10.88 4 158341 6209 42456781
Mastitis 12.05 10.88 8 158337 184 42462806
Meningitis bacterial 12.04 10.88 20 158325 1389 42461601
Marrow hyperplasia 12.00 10.88 19 158326 1268 42461722
Varicella zoster pneumonia 11.99 10.88 9 158336 253 42462737
Postural tremor 11.99 10.88 12 158333 501 42462489
Abnormal behaviour 11.94 10.88 54 158291 26397 42436593
Joint stiffness 11.94 10.88 17 158328 12305 42450685
C-reactive protein increased 11.93 10.88 315 158030 63245 42399745
Extravasation 11.91 10.88 27 158318 2363 42460627
Herpes zoster meningoencephalitis 11.91 10.88 12 158333 505 42462485
Dermatitis exfoliative generalised 11.89 10.88 48 158297 5776 42457214
Encephalomyelitis 11.86 10.88 7 158338 130 42462860
Neutrophil morphology abnormal 11.85 10.88 6 158339 81 42462909
Renal cancer 11.84 10.88 8 158337 8216 42454774
Rhinovirus infection 11.83 10.88 52 158293 6496 42456494
Pancreatic abscess 11.83 10.88 8 158337 190 42462800
Coombs direct test positive 11.80 10.88 10 158335 336 42462654
Oral disorder 11.75 10.88 42 158303 4770 42458220
Biopsy skin abnormal 11.72 10.88 6 158339 83 42462907
Skin ulcer 11.72 10.88 52 158293 25549 42437441
Pulmonary toxicity 11.70 10.88 9 158336 8646 42454344
Blood creatinine increased 11.67 10.88 510 157835 109493 42353497
Anger 11.62 10.88 19 158326 12999 42449991
Cerebral infarction 11.61 10.88 68 158277 31101 42431889
Liver function test 11.60 10.88 6 158339 85 42462905
Fibrous histiocytoma 11.55 10.88 10 158335 346 42462644
Necrotising ulcerative gingivostomatitis 11.53 10.88 6 158339 86 42462904
Metapneumovirus infection 11.49 10.88 18 158327 1190 42461800
Cerebrovascular accident 11.46 10.88 274 158071 96886 42366104
Oral mucosal exfoliation 11.44 10.88 8 158337 201 42462789
Increased tendency to bruise 11.42 10.88 39 158306 4331 42458659
Adenoviral haemorrhagic cystitis 11.42 10.88 12 158333 531 42462459
Haematopoietic stem cell mobilisation 11.41 10.88 10 158335 352 42462638
Cardiac failure 11.36 10.88 306 158039 106550 42356440
Lung neoplasm malignant 11.32 10.88 35 158310 19112 42443878
Alveolitis necrotising 11.30 10.88 4 158341 20 42462970
Renal tubular disorder 11.28 10.88 42 158303 4867 42458123
Gastroenteritis adenovirus 11.23 10.88 8 158337 207 42462783
JC virus CSF test positive 11.23 10.88 7 158338 144 42462846
Glomerulosclerosis 11.20 10.88 15 158330 859 42462131
Viraemia 11.15 10.88 22 158323 1748 42461242
Tooth infection 11.14 10.88 59 158286 7952 42455038
Anal cancer 11.09 10.88 11 158334 454 42462536
Agitation 11.08 10.88 170 158175 64144 42398846
BK virus infection 11.08 10.88 63 158282 8721 42454269
Post herpetic neuralgia 11.07 10.88 18 158327 1228 42461762
Pancreatitis acute 11.07 10.88 76 158269 33488 42429502
Asterixis 11.05 10.88 19 158326 1358 42461632
Transfusion-related acute lung injury 11.03 10.88 8 158337 213 42462777
Gallbladder disorder 11.00 10.88 55 158290 7247 42455743
Blood triglycerides increased 10.93 10.88 27 158318 15869 42447121
Product use issue 10.93 10.88 210 158135 76541 42386449
Unresponsive to stimuli 10.92 10.88 70 158275 31333 42431657
Pneumonia parainfluenzae viral 10.89 10.88 9 158336 292 42462698
Duodenal ulcer 10.88 10.88 18 158327 12261 42450729
Cataract subcapsular 10.88 10.88 12 158333 561 42462429

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Plasma cell myeloma 2845.44 10.14 1822 267718 61114 110258645
Febrile neutropenia 1543.16 10.14 2766 266774 314001 110005758
Cytokine release syndrome 1297.23 10.14 1194 268346 69112 110250647
Neutropenia 1248.29 10.14 2792 266748 371828 109947931
White blood cell count decreased 1202.95 10.14 2070 267470 227320 110092439
Platelet count decreased 1134.99 10.14 2023 267517 228420 110091339
Pneumonia 920.83 10.14 4395 265145 872319 109447440
Neutrophil count decreased 748.81 10.14 1177 268363 119764 110199995
Pyrexia 727.23 10.14 4191 265349 894074 109425685
Neurotoxicity 692.67 10.14 672 268868 41535 110278224
Thrombocytopenia 669.12 10.14 2119 267421 346766 109972993
Neuropathy peripheral 651.40 10.14 1385 268155 177892 110141867
Synovitis 634.59 10.14 6 269534 274086 110045673
Lymphocyte count decreased 608.29 10.14 724 268816 56519 110263240
Rheumatoid arthritis 566.34 10.14 43 269497 299570 110020189
Full blood count decreased 519.05 10.14 507 269033 31592 110288167
Cytomegalovirus infection 509.63 10.14 646 268894 53798 110265961
Sepsis 509.19 10.14 1854 267686 325492 109994267
Systemic lupus erythematosus 502.74 10.14 29 269511 254309 110065450
Pemphigus 490.66 10.14 6 269534 214564 110105195
Contraindicated product administered 462.52 10.14 38 269502 248229 110071530
Joint swelling 447.66 10.14 262 269278 442583 109877176
Pancytopenia 445.09 10.14 1320 268220 208293 110111466
Urine abnormality 442.27 10.14 276 269264 8820 110310939
Graft versus host disease 438.34 10.14 365 269175 18441 110301318
Drug intolerance 428.91 10.14 228 269312 406284 109913475
Acute kidney injury 428.44 10.14 2831 266709 632599 109687160
Duodenal ulcer perforation 415.54 10.14 3 269537 177697 110142062
Glossodynia 405.31 10.14 37 269503 221967 110097792
Helicobacter infection 395.72 10.14 10 269530 181867 110137892
Arthralgia 394.09 10.14 819 268721 778813 109540946
Psoriatic arthropathy 390.16 10.14 22 269518 196739 110123020
Therapeutic product effect decreased 371.87 10.14 72 269468 244244 110075515
Wound 369.96 10.14 63 269477 234374 110085385
Completed suicide 363.53 10.14 74 269466 242307 110077452
Immune effector cell-associated neurotoxicity syndrome 359.34 10.14 294 269246 14488 110305271
Drug hypersensitivity 349.15 10.14 355 269185 453735 109866024
Arthropathy 342.40 10.14 136 269404 287386 110032373
Pericarditis 336.81 10.14 63 269477 219051 110100708
Alopecia 310.10 10.14 260 269280 364493 109955266
Drug abuse 307.21 10.14 36 269504 177375 110142384
Type 2 diabetes mellitus 304.33 10.14 37 269503 177195 110142564
Mucosal inflammation 304.08 10.14 703 268837 95438 110224321
Septic shock 297.94 10.14 953 268587 156575 110163184
Urine leukocyte esterase positive 297.21 10.14 157 269383 3629 110316130
Multiple organ dysfunction syndrome 297.18 10.14 929 268611 150781 110168978
Pain 294.55 10.14 1263 268277 953692 109366067
Maternal exposure during pregnancy 288.34 10.14 130 269410 254753 110065006
Muscle injury 287.84 10.14 13 269527 140794 110178965
Discomfort 287.84 10.14 83 269457 214624 110105135
C-reactive protein abnormal 282.61 10.14 7 269533 129688 110190071
Impaired healing 278.96 10.14 68 269472 196649 110123110
Acute graft versus host disease 275.57 10.14 238 269302 12643 110307116
Irritable bowel syndrome 275.39 10.14 37 269503 164178 110155581
Epstein-Barr virus infection 269.89 10.14 278 269262 18460 110301299
Folliculitis 269.05 10.14 43 269497 167610 110152149
Crystal urine present 261.21 10.14 117 269423 1857 110317902
Swelling 256.80 10.14 286 269254 350755 109969004
Urinary sediment present 254.43 10.14 124 269416 2404 110317355
Toxicity to various agents 249.06 10.14 497 269043 480058 109839701
Post transplant lymphoproliferative disorder 245.67 10.14 243 269297 15370 110304389
Hypersensitivity 242.58 10.14 381 269159 403617 109916142
Red blood cells urine positive 241.22 10.14 153 269387 5032 110314727
Drug resistance 240.72 10.14 466 269074 55908 110263851
Bursitis 238.83 10.14 21 269519 129897 110189862
Treatment failure 237.55 10.14 196 269344 277038 110042721
Encephalopathy 236.05 10.14 574 268966 80481 110239278
Cytomegalovirus viraemia 235.24 10.14 252 269288 17512 110302247
White blood cells urine positive 231.41 10.14 172 269368 7352 110312407
Pathogen resistance 231.04 10.14 249 269291 17423 110302336
Herpes simplex 230.88 10.14 236 269304 15528 110304231
Mobility decreased 230.58 10.14 147 269393 237275 110082484
Encephalitis viral 228.44 10.14 122 269418 2885 110316874
Lymphocyte percentage decreased 228.05 10.14 149 269391 5161 110314598
Diarrhoea 226.22 10.14 3964 265576 1135541 109184218
Musculoskeletal stiffness 223.88 10.14 211 269329 279611 110040148
Thrombosis 222.61 10.14 676 268864 107986 110211773
Injury 222.48 10.14 77 269463 177188 110142571
Urine analysis abnormal 221.88 10.14 162 269378 6735 110313024
Obesity 220.65 10.14 14 269526 113337 110206422
Facet joint syndrome 220.01 10.14 3 269537 96825 110222934
Deep vein thrombosis 218.54 10.14 794 268746 139093 110180666
Meningoencephalitis herpetic 218.54 10.14 110 269430 2292 110317467
Bronchopulmonary aspergillosis 217.92 10.14 314 269226 29549 110290210
Neutrophil percentage increased 216.25 10.14 140 269400 4773 110314986
Blood cholesterol increased 214.09 10.14 91 269449 184694 110135065
Joint range of motion decreased 200.61 10.14 29 269511 121803 110197956
Injection site pain 197.68 10.14 93 269447 177829 110141930
Acute myeloid leukaemia 196.78 10.14 342 269198 37768 110281991
Tumour lysis syndrome 196.34 10.14 304 269236 30497 110289262
Lip dry 190.02 10.14 14 269526 100069 110219690
Plasma cell myeloma recurrent 188.05 10.14 148 269392 6894 110312865
Encephalitis 186.57 10.14 230 269310 18609 110301150
Weight increased 186.36 10.14 472 269068 419172 109900587
Cytopenia 186.07 10.14 293 269247 29823 110289936
Abdominal discomfort 185.95 10.14 429 269111 393429 109926330
Osteoarthritis 185.79 10.14 107 269433 182516 110137243
Intentional overdose 185.50 10.14 47 269493 132454 110187305
Ill-defined disorder 182.09 10.14 77 269463 156776 110162983
Hepatic enzyme increased 181.96 10.14 314 269226 320578 109999181
COVID-19 pneumonia 178.48 10.14 323 269217 36820 110282939
Constipation 173.48 10.14 1476 268064 356310 109963449
Cytomegalovirus infection reactivation 172.25 10.14 218 269322 18115 110301644
Infusion related reaction 171.34 10.14 426 269114 380736 109939023
Haemophagocytic lymphohistiocytosis 170.54 10.14 289 269251 31270 110288489
Acute graft versus host disease in skin 170.54 10.14 168 269372 10572 110309187
Chronic graft versus host disease 169.23 10.14 158 269382 9299 110310460
Varicella zoster virus infection 166.11 10.14 132 269408 6236 110313523
Neutropenic sepsis 164.09 10.14 280 269260 30466 110289293
Sensitisation 162.62 10.14 110 269430 4041 110315718
Blood urine present 162.58 10.14 245 269295 24000 110295759
Musculoskeletal pain 162.25 10.14 125 269415 182898 110136861
Intentional product misuse 159.55 10.14 62 269478 132842 110186917
Acute graft versus host disease in intestine 155.96 10.14 121 269419 5518 110314241
Liver injury 154.61 10.14 87 269453 150326 110169433
Sleep disorder 151.68 10.14 156 269384 198488 110121271
Sleep disorder due to general medical condition, insomnia type 150.75 10.14 36 269504 105607 110214152
Inflammation 150.69 10.14 149 269391 193089 110126670
Crystalluria 150.14 10.14 71 269469 1284 110318475
Wheezing 149.98 10.14 244 269296 254986 110064773
COVID-19 148.62 10.14 1065 268475 243995 110075764
Polycystic ovaries 148.31 10.14 110 269430 4686 110315073
Respiratory failure 147.32 10.14 964 268576 214368 110105391
Anaemia 147.10 10.14 2005 267535 545081 109774678
Psoriasis 145.30 10.14 80 269460 139913 110179846
Nephropathy toxic 145.01 10.14 249 269291 27229 110292530
Peripheral venous disease 143.30 10.14 18 269522 84099 110235660
Bacterial test 143.20 10.14 66 269474 1123 110318636
Arthritis 142.86 10.14 119 269421 167467 110152292
Renal failure 141.08 10.14 991 268549 225583 110094176
Death 139.85 10.14 2436 267104 696433 109623326
Fibromyalgia 138.86 10.14 127 269413 170782 110148977
Red blood cell count decreased 138.64 10.14 414 269126 65509 110254250
Haematotoxicity 135.66 10.14 209 269331 20873 110298886
Bacterial test positive 134.58 10.14 129 269411 7848 110311911
Rash 133.59 10.14 2772 266768 818192 109501567
Sciatica 132.80 10.14 31 269509 92368 110227391
Blood creatinine increased 132.00 10.14 830 268710 182059 110137700
Lymphopenia 131.68 10.14 298 269242 39872 110279887
Wound infection 131.63 10.14 36 269504 96429 110223330
Human herpesvirus 6 infection 131.55 10.14 117 269423 6464 110313295
Pulmonary fibrosis 130.32 10.14 43 269497 101999 110217760
Overdose 127.77 10.14 234 269306 233560 110086199
Urine ketone body present 127.50 10.14 92 269448 3754 110316005
Herpes zoster 127.37 10.14 563 268977 107816 110211943
Knee arthroplasty 126.46 10.14 8 269532 64940 110254819
Pre-engraftment immune reaction 126.08 10.14 46 269494 413 110319346
Aplastic anaemia 125.30 10.14 218 269322 24090 110295669
Condition aggravated 124.86 10.14 1167 268373 733669 109586090
Haemoglobin decreased 123.06 10.14 1031 268509 247696 110072063
Gastrointestinal disorder 122.82 10.14 253 269287 241699 110078060
Antiviral drug level above therapeutic 122.77 10.14 32 269508 73 110319686
Pneumonia fungal 122.38 10.14 165 269375 14589 110305170
Ejection fraction 122.24 10.14 81 269459 2874 110316885
Enterococcal infection 121.48 10.14 195 269345 20171 110299588
Red blood cell sedimentation rate increased 121.37 10.14 22 269518 78280 110241479
Chronic lymphocytic leukaemia 121.08 10.14 107 269433 5861 110313898
Blister 118.63 10.14 234 269306 227142 110092617
Live birth 118.04 10.14 15 269525 69469 110250290
Intentional product use issue 117.75 10.14 269 269271 247637 110072122
Smooth muscle cell neoplasm 117.62 10.14 61 269479 1356 110318403
Cytomegalovirus test positive 115.34 10.14 112 269428 6924 110312835
Atrial fibrillation 115.25 10.14 955 268585 228687 110091072
Suicide attempt 113.36 10.14 55 269485 103339 110216420
Cystitis haemorrhagic 112.83 10.14 144 269396 12065 110307694
Bacteraemia 112.68 10.14 290 269250 42100 110277659
Hypogammaglobulinaemia 112.68 10.14 187 269353 19889 110299870
Venoocclusive liver disease 112.56 10.14 161 269379 15046 110304713
Road traffic accident 111.99 10.14 61 269479 107337 110212422
Herpes virus infection 111.67 10.14 121 269419 8517 110311242
Culture urine positive 111.58 10.14 93 269447 4703 110315056
Bacterial sepsis 110.92 10.14 132 269408 10294 110309465
Asthma 110.64 10.14 282 269258 250009 110069750
Toxoplasmosis 108.57 10.14 78 269462 3161 110316598
Inappropriate schedule of product administration 108.46 10.14 207 269333 203430 110116329
Renal disorder 105.24 10.14 312 269228 49167 110270592
Prescribed overdose 104.87 10.14 41 269499 87540 110232219
Monocyte percentage increased 104.75 10.14 67 269473 2236 110317523
Graft versus host disease in gastrointestinal tract 104.53 10.14 119 269421 8849 110310910
Acute myeloid leukaemia recurrent 103.99 10.14 92 269448 5047 110314712
Aspergillus infection 103.59 10.14 207 269333 25409 110294350
Laboratory test abnormal 103.49 10.14 288 269252 43791 110275968
General physical health deterioration 103.48 10.14 610 268930 424685 109895074
Pneumonia cytomegaloviral 103.46 10.14 105 269435 6849 110312910
Lower limb fracture 103.03 10.14 28 269512 75320 110244439
Diffuse large B-cell lymphoma 102.85 10.14 158 269382 15740 110304019
Clostridium difficile colitis 102.75 10.14 286 269254 43492 110276267
Toxic encephalopathy 102.38 10.14 154 269386 15060 110304699
Exposure during pregnancy 102.18 10.14 156 269384 167268 110152491
Light chain analysis increased 100.93 10.14 66 269474 2289 110317470
Pain in extremity 100.66 10.14 734 268806 486384 109833375
Migraine 99.97 10.14 165 269375 171487 110148272
Dry mouth 99.85 10.14 211 269329 199737 110120022
Product use issue 99.54 10.14 406 269134 311289 110008470
Lung disorder 99.44 10.14 179 269361 179868 110139891
Mucormycosis 99.24 10.14 126 269414 10502 110309257
Stem cell transplant 99.19 10.14 84 269456 4343 110315416
Adenovirus infection 98.98 10.14 128 269412 10866 110308893
Depression 97.84 10.14 419 269121 316916 110002843
Hyperbilirubinaemia 97.72 10.14 225 269315 30446 110289313
Haemoglobin urine present 97.67 10.14 47 269493 885 110318874
Onychomadesis 97.48 10.14 3 269537 45660 110274099
Graft versus host disease in skin 97.01 10.14 110 269430 8144 110311615
Gait inability 96.49 10.14 114 269426 136262 110183497
Injection site reaction 95.21 10.14 49 269491 89021 110230738
Sedation 95.08 10.14 26 269514 69657 110250102
Hip arthroplasty 94.93 10.14 12 269528 55801 110263958
Plasmacytoma 94.32 10.14 88 269452 5174 110314585
Therapeutic product effect incomplete 93.72 10.14 259 269281 223546 110096213
Red cell distribution width increased 93.53 10.14 160 269380 17442 110302317
Frequent bowel movements 93.08 10.14 29 269511 71361 110248398
Thrombotic microangiopathy 93.05 10.14 214 269326 28935 110290824
Chills 92.65 10.14 787 268753 189793 110129966
Autoimmune disorder 92.08 10.14 23 269517 65460 110254299
Grip strength decreased 92.01 10.14 40 269500 80134 110239625
Product quality issue 91.22 10.14 37 269503 77262 110242497
Hypercholesterolaemia 89.86 10.14 55 269485 90782 110228977
Malaise 89.15 10.14 1129 268411 670690 109649069
Coeliac disease 88.20 10.14 4 269536 43183 110276576
Ophthalmic herpes simplex 86.52 10.14 43 269497 871 110318888
Specific gravity urine decreased 84.81 10.14 42 269498 844 110318915
Systemic candida 83.42 10.14 112 269428 9862 110309897
Respiratory syncytial virus infection 82.75 10.14 136 269404 14348 110305411
Blood lactate dehydrogenase increased 82.63 10.14 267 269273 44067 110275692
Influenza 82.56 10.14 699 268841 168402 110151357
Blood pressure systolic increased 82.44 10.14 50 269490 82941 110236818
Nail disorder 82.14 10.14 20 269520 57915 110261844
Hypoglycaemia 81.12 10.14 98 269442 116006 110203753
Foot deformity 81.07 10.14 11 269529 48469 110271290
Staphylococcal infection 80.40 10.14 361 269179 69583 110250176
Lower respiratory tract infection 79.92 10.14 313 269227 242793 110076966
Lupus-like syndrome 79.49 10.14 5 269535 40787 110278972
Osteoporosis 77.88 10.14 59 269481 87093 110232666
Underdose 77.34 10.14 29 269511 63525 110256234
Nitrite urine present 77.03 10.14 44 269496 1191 110318568
Acute lymphocytic leukaemia recurrent 76.45 10.14 82 269458 5705 110314054
Blood bilirubin increased 76.28 10.14 377 269163 75595 110244164
Colitis ulcerative 74.92 10.14 48 269492 77315 110242444
Wrong technique in product usage process 74.45 10.14 62 269478 87286 110232473
Necrotising retinitis 74.01 10.14 47 269493 1549 110318210
Blepharospasm 73.84 10.14 21 269519 54830 110264929
Exostosis 73.22 10.14 12 269528 45944 110273815
Anxiety 72.67 10.14 517 269023 344561 109975198
Systemic mycosis 72.45 10.14 66 269474 3763 110315996
Incorrect route of product administration 71.88 10.14 33 269507 64028 110255731
Blood pressure fluctuation 71.68 10.14 47 269493 74777 110244982
Drug dependence 71.44 10.14 17 269523 50003 110269756
Hepatic cirrhosis 71.10 10.14 38 269502 67588 110252171
Renal impairment 70.96 10.14 737 268803 187708 110132051
Suicidal ideation 70.30 10.14 75 269465 93862 110225897
Venoocclusive disease 70.21 10.14 82 269458 6268 110313491
Specific gravity urine increased 68.81 10.14 31 269509 499 110319260
Haematocrit decreased 68.45 10.14 331 269209 65786 110253973
Pleocytosis 68.29 10.14 46 269494 1678 110318081
Engraftment syndrome 68.16 10.14 48 269492 1884 110317875
Rash maculo-papular 68.01 10.14 359 269181 73863 110245896
Fatigue 67.84 10.14 3616 265924 1212342 109107417
Cytomegalovirus chorioretinitis 67.34 10.14 85 269455 7043 110312716
Intentional self-injury 66.27 10.14 7 269533 37422 110282337
Alanine aminotransferase increased 65.58 10.14 711 268829 183062 110136697
Medication error 65.42 10.14 97 269443 105269 110214490
Fusarium infection 65.02 10.14 54 269486 2717 110317042
Drug interaction 64.27 10.14 846 268694 499337 109820422
Ejection fraction abnormal 64.22 10.14 59 269481 3401 110316358
Injection site swelling 63.11 10.14 36 269504 61754 110258005
Injection site bruising 63.04 10.14 23 269517 51240 110268519
Nervous system disorder 62.74 10.14 195 269345 31526 110288233
Organic brain syndrome 62.72 10.14 30 269510 557 110319202
Back injury 62.25 10.14 19 269521 47380 110272379
Rectal haemorrhage 61.89 10.14 124 269416 119709 110200050
Sopor 61.81 10.14 8 269532 36538 110283221
Epstein-Barr virus associated lymphoproliferative disorder 61.61 10.14 67 269473 4735 110315024
Nephrectomy 61.02 10.14 51 269489 2589 110317170
Pregnancy 60.98 10.14 24 269516 51043 110268716
Blood pressure increased 59.95 10.14 376 269164 257997 110061762
Hypertension 59.05 10.14 881 268659 509203 109810556
C-reactive protein 58.27 10.14 4 269536 30327 110289432
Toxic epidermal necrolysis 58.01 10.14 283 269257 56444 110263315
Blood test abnormal 57.84 10.14 177 269363 28377 110291382
Plasma cell myeloma refractory 57.66 10.14 44 269496 1957 110317802
Pleural effusion 56.39 10.14 672 268868 177037 110142722
Acute generalised exanthematous pustulosis 56.33 10.14 147 269393 21517 110298242
Candida infection 56.08 10.14 249 269291 47760 110271999
Contusion 55.49 10.14 337 269203 233024 110086735
Night sweats 55.37 10.14 156 269384 133827 110185932
Monoclonal immunoglobulin increased 55.21 10.14 28 269512 593 110319166
Mental status changes 55.21 10.14 346 269194 75776 110243983
Encephalitis cytomegalovirus 55.04 10.14 42 269498 1868 110317891
Escherichia bacteraemia 54.81 10.14 93 269447 10071 110309688
Injection site erythema 54.38 10.14 91 269449 94085 110225674
Anaphylactic reaction 54.26 10.14 124 269416 114176 110205583
Graft versus host disease in liver 53.65 10.14 46 269494 2419 110317340
Parainfluenzae virus infection 53.33 10.14 75 269465 6899 110312860
International normalised ratio increased 52.78 10.14 81 269459 86691 110233068
Staphylococcal bacteraemia 52.70 10.14 122 269418 16566 110303193
Leukopenia 52.31 10.14 574 268966 148217 110171542
Drug tolerance decreased 51.85 10.14 4 269536 27536 110292223
Fungal infection 51.63 10.14 253 269287 50553 110269206
Onychomycosis 51.41 10.14 15 269525 38516 110281243
Pseudomonas infection 51.23 10.14 167 269373 27686 110292073
Disseminated intravascular coagulation 51.18 10.14 218 269322 41068 110278691
IVth nerve paralysis 50.80 10.14 27 269513 632 110319127
Retinitis viral 50.70 10.14 24 269516 435 110319324
Herpes simplex viraemia 50.42 10.14 27 269513 642 110319117
Vomiting 50.26 10.14 1766 267774 908909 109410850
Pneumocystis jirovecii pneumonia 50.19 10.14 222 269318 42513 110277246
Rhinitis allergic 50.12 10.14 125 269415 17797 110301962
Accidental exposure to product 49.84 10.14 30 269510 49978 110269781
Pneumonia bacterial 49.70 10.14 159 269381 26102 110293657
Aspartate aminotransferase increased 49.52 10.14 602 268938 159334 110160425
Joint stiffness 48.86 10.14 55 269485 67188 110252571
Pulmonary embolism 48.77 10.14 764 268776 213710 110106049
Drug reaction with eosinophilia and systemic symptoms 48.67 10.14 355 269185 81740 110238019
Encephalitis autoimmune 48.39 10.14 51 269489 3477 110316282
Disease progression 48.39 10.14 850 268690 243184 110076575
Enterococcal bacteraemia 48.31 10.14 57 269483 4404 110315355
CSF protein increased 47.91 10.14 35 269505 1456 110318303
Meningitis aseptic 47.62 10.14 86 269454 9784 110309975
Plasma cell leukaemia 47.56 10.14 40 269500 2048 110317711
Varicella virus test positive 47.43 10.14 22 269518 380 110319379
Acute graft versus host disease in liver 47.27 10.14 42 269498 2317 110317442
Pneumonia influenzal 46.93 10.14 52 269488 3753 110316006
Status epilepticus 46.58 10.14 176 269364 31395 110288364
Blood potassium decreased 46.36 10.14 257 269283 53857 110265902
Thyroxine free increased 46.36 10.14 34 269506 1423 110318336
Mantle cell lymphoma 46.13 10.14 36 269504 1656 110318103
Pneumonia viral 46.12 10.14 91 269449 11066 110308693
Cystitis viral 46.03 10.14 34 269506 1439 110318320
Laryngitis 45.82 10.14 23 269517 42388 110277371
Bone marrow failure 45.80 10.14 269 269271 57579 110262180
Band sensation 45.69 10.14 30 269510 1048 110318711
Tremor 45.46 10.14 719 268821 201513 110118246
Weight decreased 45.41 10.14 835 268705 467222 109852537
Engraft failure 45.11 10.14 27 269513 799 110318960
Ageusia 44.78 10.14 127 269413 19518 110300241
Carpal tunnel syndrome 44.72 10.14 139 269401 22471 110297288
Bilirubin urine present 44.62 10.14 20 269520 318 110319441
Immune thrombocytopenia 44.23 10.14 138 269402 22356 110297403
Obstructive airways disorder 44.18 10.14 29 269511 46120 110273639
Acute lymphocytic leukaemia 44.09 10.14 62 269478 5703 110314056
Rash pruritic 44.01 10.14 398 269142 97671 110222088
Escherichia sepsis 43.94 10.14 85 269455 10187 110309572
Lactic acidosis 43.80 10.14 101 269439 92710 110227049
Corynebacterium bacteraemia 43.38 10.14 17 269523 189 110319570
Factor XIII deficiency 43.23 10.14 14 269526 84 110319675
Herpes ophthalmic 43.10 10.14 36 269504 1826 110317933
Fungaemia 42.95 10.14 63 269477 6023 110313736
Listeriosis 42.80 10.14 43 269497 2771 110316988
Mean cell haemoglobin concentration increased 42.76 10.14 29 269511 1070 110318689
Cardiogenic shock 42.65 10.14 46 269494 57292 110262467
Leukaemia recurrent 42.48 10.14 45 269495 3086 110316673
Neuroleptic malignant syndrome 42.36 10.14 15 269525 34044 110285715
Epstein-Barr virus infection reactivation 42.28 10.14 51 269489 4033 110315726
Urinary casts 42.20 10.14 31 269509 1301 110318458
Febrile infection 41.95 10.14 53 269487 4395 110315364
Lymphadenopathy 41.92 10.14 283 269257 63552 110256207
Off label use 41.81 10.14 4219 265321 1495966 108823793
Pneumonia respiratory syncytial viral 41.80 10.14 42 269498 2707 110317052
Therapeutic response decreased 41.63 10.14 110 269430 96389 110223370
Prescribed underdose 41.43 10.14 59 269481 65115 110254644
Blood thyroid stimulating hormone decreased 41.39 10.14 68 269472 7171 110312588
Monocyte count decreased 41.37 10.14 49 269491 3802 110315957
Band neutrophil percentage increased 41.21 10.14 20 269520 384 110319375
Stevens-Johnson syndrome 41.02 10.14 224 269316 46677 110273082
Joint dislocation 40.94 10.14 16 269524 34174 110285585
Central nervous system lesion 40.92 10.14 106 269434 15447 110304312
Stenotrophomonas infection 40.42 10.14 60 269480 5798 110313961
Enterococcal sepsis 40.40 10.14 45 269495 3267 110316492
Cells in urine 40.12 10.14 16 269524 187 110319572
Multiple sclerosis relapse 40.02 10.14 234 269306 50006 110269753
Body temperature decreased 39.95 10.14 20 269520 36915 110282844
Extravasation 39.90 10.14 54 269486 4791 110314968
Anaphylactic shock 39.87 10.14 40 269500 51506 110268253
Urine leukocyte esterase 39.74 10.14 16 269524 192 110319567
Maternal exposure timing unspecified 39.71 10.14 3 269537 21010 110298749
Rhabdomyolysis 39.55 10.14 155 269385 120246 110199513
Nasopharyngitis 39.35 10.14 700 268840 393661 109926098
Acute respiratory failure 39.34 10.14 316 269224 74944 110244815
Disseminated mucormycosis 39.32 10.14 36 269504 2066 110317693
Rhinovirus infection 39.24 10.14 88 269452 11701 110308058
Drug ineffective 39.14 10.14 3184 266356 1517356 108802403
pH urine increased 39.04 10.14 20 269520 433 110319326
Hypoxia 39.01 10.14 485 269055 129030 110190729
Retinitis 38.92 10.14 15 269525 32312 110287447
Renal tubular disorder 38.78 10.14 67 269473 7362 110312397
Dyspnoea 38.51 10.14 2257 267283 1104615 109215144
Clostridium difficile infection 38.46 10.14 238 269302 51891 110267868
Haemorrhage intracranial 38.29 10.14 156 269384 28813 110290946
Loss of personal independence in daily activities 38.13 10.14 212 269328 149808 110169951
Pulmonary thrombosis 38.04 10.14 96 269444 13767 110305992
Staphylococcal sepsis 38.01 10.14 111 269429 17343 110302416
Ulcer 37.49 10.14 30 269510 43086 110276673
Injection site pruritus 37.16 10.14 42 269498 51216 110268543
Post herpetic neuralgia 37.12 10.14 43 269497 3258 110316501
Device issue 36.90 10.14 19 269521 34516 110285243
Therapeutic response shortened 36.84 10.14 13 269527 29570 110290189
Differentiation syndrome 36.51 10.14 41 269499 3003 110316756
Pseudomonal sepsis 36.45 10.14 73 269467 8973 110310786
Transplant failure 36.44 10.14 56 269484 5579 110314180
Blood pressure diastolic abnormal 36.42 10.14 9 269531 25806 110293953
Stress 36.31 10.14 133 269407 105215 110214544
Neutrophil count abnormal 36.04 10.14 53 269487 5079 110314680
Neutropenic infection 36.04 10.14 42 269498 3203 110316556
Idiopathic pneumonia syndrome 35.93 10.14 24 269516 863 110318896
Device malfunction 35.89 10.14 9 269531 25549 110294210
Peripheral swelling 35.75 10.14 732 268808 403302 109916457
Geotrichum infection 35.70 10.14 27 269513 1185 110318574
Injection site haemorrhage 35.55 10.14 18 269522 33010 110286749
Dyspepsia 35.52 10.14 296 269244 190669 110129090
Sinusitis 35.48 10.14 509 269031 296179 110023580
Stomatitis 35.43 10.14 455 269085 269787 110049972
Blood pressure diastolic decreased 35.11 10.14 22 269518 35863 110283896
Klebsiella infection 35.04 10.14 118 269422 19891 110299868
Drug withdrawal syndrome 34.98 10.14 25 269515 38029 110281730
Herpes simplex encephalitis 34.56 10.14 23 269517 822 110318937
Pneumonia pneumococcal 34.47 10.14 51 269489 4914 110314845
Miosis 34.45 10.14 6 269534 21977 110297782
Abdominal pain upper 34.40 10.14 621 268919 348490 109971269
Meningitis 34.19 10.14 83 269457 11619 110308140
Schizophrenia 34.11 10.14 6 269534 21820 110297939
Campylobacter gastroenteritis 34.07 10.14 32 269508 1897 110317862
Human herpesvirus 6 encephalitis 34.03 10.14 25 269515 1049 110318710
Metastases to bone 33.91 10.14 17 269523 31355 110288404
CD4 lymphocytes decreased 33.88 10.14 39 269501 2935 110316824
Oral herpes 33.38 10.14 175 269365 35905 110283854
Fibrin D dimer increased 33.34 10.14 74 269466 9771 110309988
Swollen tongue 33.32 10.14 60 269480 60302 110259457
Procedural pain 33.18 10.14 23 269517 35542 110284217
Protein urine present 33.07 10.14 81 269459 11403 110308356
Bacterial infection 32.60 10.14 208 269332 45828 110273931
Splenomegaly 32.44 10.14 132 269408 24366 110295393
Herpes zoster meningoencephalitis 31.72 10.14 24 269516 1054 110318705
Epilepsy 31.66 10.14 131 269409 100078 110219681
Tumour flare 31.60 10.14 28 269512 1539 110318220
Mean cell haemoglobin decreased 31.47 10.14 60 269480 7114 110312645
Cardiac disorder 31.43 10.14 304 269236 75976 110243783
Eosinophil percentage increased 31.37 10.14 28 269512 1554 110318205
Brain stem stroke 31.32 10.14 21 269519 760 110318999
Leukocyturia 31.11 10.14 33 269507 2267 110317492
Klebsiella bacteraemia 30.95 10.14 48 269492 4821 110314938
Urinary tract infection 30.74 10.14 1026 268514 325256 109994503
Squamous cell carcinoma of skin 30.61 10.14 102 269438 17101 110302658
Adverse reaction 30.57 10.14 17 269523 29577 110290182
Band neutrophil count increased 30.55 10.14 20 269520 695 110319064
Angioedema 30.35 10.14 130 269410 98370 110221389
Meningitis cryptococcal 30.34 10.14 47 269493 4715 110315044
Injection site mass 30.34 10.14 11 269529 24602 110295157
Oxygen saturation decreased 30.25 10.14 241 269299 156741 110163018
Haematochezia 30.04 10.14 162 269378 115362 110204397
Abdominal wall infection 29.88 10.14 12 269528 143 110319616
Sedation complication 29.87 10.14 6 269534 19849 110299910
Device difficult to use 29.76 10.14 5 269535 18800 110300959
Viral haemorrhagic cystitis 29.70 10.14 39 269501 3360 110316399
Streptococcal bacteraemia 29.64 10.14 46 269494 4623 110315136
Lower respiratory tract infection fungal 29.56 10.14 21 269519 836 110318923
Blood thyroid stimulating hormone increased 29.49 10.14 81 269459 12220 110307539
Female genital tract fistula 29.47 10.14 3 269537 16516 110303243
Eczema herpeticum 29.47 10.14 17 269523 469 110319290
Lung infiltration 28.96 10.14 128 269412 24500 110295259
Hypokalaemia 28.83 10.14 614 268926 181834 110137925
Myelodysplastic syndrome 28.83 10.14 173 269367 37311 110282448
Aplasia 28.74 10.14 61 269479 7812 110311947
Memory impairment 28.70 10.14 324 269216 196620 110123139
Blood immunoglobulin G decreased 28.58 10.14 49 269491 5351 110314408
Urine oxalate increased 28.54 10.14 13 269527 215 110319544
Myoclonic dystonia 28.53 10.14 10 269530 79 110319680
Dehydration 28.42 10.14 887 268653 278624 110041135
Lipaemic index score 28.42 10.14 11 269529 118 110319641
Bone marrow transplant 28.30 10.14 27 269513 1633 110318126
Red cell distribution width decreased 28.29 10.14 31 269509 2210 110317549
Dyslalia 28.25 10.14 25 269515 1372 110318387
BK virus infection 28.20 10.14 83 269457 13023 110306736
Epstein-Barr viraemia 28.13 10.14 39 269501 3540 110316219
Magnetic resonance imaging abnormal 28.08 10.14 41 269499 3904 110315855
Haemodialysis 28.00 10.14 101 269439 17618 110302141
Metastases to liver 27.90 10.14 27 269513 35359 110284400
Meningitis listeria 27.81 10.14 24 269516 1273 110318486
Oedema 27.71 10.14 353 269187 209623 110110136
Diffuse cutaneous mastocytosis 27.56 10.14 8 269532 31 110319728
Meningitis bacterial 27.41 10.14 36 269504 3103 110316656
Blood creatine phosphokinase increased 27.38 10.14 89 269451 72988 110246771
Infusion site reaction 27.33 10.14 5 269535 17677 110302082
Urobilinogen urine increased 27.30 10.14 18 269522 633 110319126
Sepsis syndrome 27.28 10.14 26 269514 1570 110318189
CSF oligoclonal band present 27.27 10.14 16 269524 456 110319303
Labelled drug-drug interaction medication error 27.27 10.14 19 269521 29283 110290476
Gait disturbance 27.05 10.14 496 269044 277712 110042047
Urine bilirubin decreased 27.03 10.14 11 269529 136 110319623
Infection reactivation 27.02 10.14 41 269499 4040 110315719
Atrial flutter 26.96 10.14 124 269416 24138 110295621
Rash macular 26.91 10.14 174 269366 38512 110281247
Red blood cells urine 26.88 10.14 18 269522 650 110319109
Tri-iodothyronine free increased 26.63 10.14 13 269527 253 110319506
Normal newborn 26.63 10.14 10 269530 21886 110297873
CSF measles antibody positive 26.61 10.14 9 269531 63 110319696
Suspected suicide 26.51 10.14 3 269537 15196 110304563
Chronic sinusitis 26.51 10.14 14 269526 25070 110294689
Posterior reversible encephalopathy syndrome 26.51 10.14 157 269383 33704 110286055
Infusion site pain 26.44 10.14 98 269442 17321 110302438
Altered state of consciousness 26.43 10.14 235 269305 57391 110262368
Breast cancer 26.42 10.14 33 269507 38509 110281250
Chronic graft versus host disease in intestine 26.35 10.14 18 269522 672 110319087
Rubella antibody positive 26.14 10.14 9 269531 67 110319692
Diabetes mellitus 26.04 10.14 139 269401 99242 110220517
Anti-platelet antibody positive 26.03 10.14 14 269526 336 110319423
Device leakage 26.00 10.14 4 269536 16044 110303715
Acute disseminated encephalomyelitis 25.97 10.14 15 269525 415 110319344
Encephalitis brain stem 25.95 10.14 14 269526 338 110319421
Nightmare 25.89 10.14 34 269506 38829 110280930
Surgery 25.62 10.14 38 269502 41245 110278514
Needle issue 25.60 10.14 6 269534 17834 110301925
Plateletcrit decreased 25.60 10.14 8 269532 42 110319717
Thyroid stimulating immunoglobulin 25.57 10.14 9 269531 72 110319687
Peripheral sensory neuropathy 25.45 10.14 94 269446 16586 110303173
West Nile viral infection 25.37 10.14 23 269517 1303 110318456
Bronchiectasis 25.28 10.14 31 269509 36462 110283297
Capillary leak syndrome 25.27 10.14 44 269496 4864 110314895
Cellulitis enterococcal 25.14 10.14 8 269532 45 110319714
Disability 25.08 10.14 22 269518 30201 110289558
Dystonia 25.00 10.14 16 269524 25789 110293970
Drug dose omission by device 24.98 10.14 3 269537 14513 110305246
Drug tolerance 24.98 10.14 5 269535 16580 110303179
Pseudomonal bacteraemia 24.91 10.14 41 269499 4330 110315429
Blast cell count increased 24.87 10.14 25 269515 1612 110318147
Autoimmune thyroiditis 24.83 10.14 51 269489 6383 110313376
Creutzfeldt-Jakob disease 24.79 10.14 12 269528 229 110319530
Impaired work ability 24.76 10.14 17 269523 26402 110293357
Respiratory arrest 24.73 10.14 67 269473 58232 110261527
Joint injury 24.64 10.14 37 269503 39957 110279802
Serum ferritin increased 24.52 10.14 74 269466 11773 110307986
Escherichia infection 24.48 10.14 119 269421 23697 110296062
Acute respiratory distress syndrome 24.43 10.14 217 269323 52981 110266778
Neutropenic colitis 24.42 10.14 58 269482 8007 110311752
Diaphragmatic injury 24.40 10.14 10 269530 126 110319633
Neutrophil Pelger-Huet anomaly present 24.38 10.14 14 269526 383 110319376
Burning sensation 24.31 10.14 267 269273 68945 110250814
Atypical pneumonia 24.30 10.14 57 269483 7805 110311954
Enterocolitis 24.22 10.14 101 269439 18848 110300911
Brain oedema 24.22 10.14 144 269396 30954 110288805
Anti-thyroid antibody positive 24.21 10.14 16 269524 565 110319194
Polyarthritis 24.19 10.14 8 269532 18955 110300804
Metastases to lung 24.18 10.14 13 269527 23050 110296709
NPM1 gene mutation 24.12 10.14 10 269530 130 110319629
Blood loss anaemia 24.08 10.14 7 269533 18018 110301741
Bronchiolitis obliterans syndrome 24.01 10.14 17 269523 673 110319086
Septic embolus 24.01 10.14 29 269511 2297 110317462
Diabetic ketoacidosis 23.94 10.14 41 269499 42017 110277742
Varicella 23.84 10.14 37 269503 3718 110316041
White blood cells urine 23.76 10.14 15 269525 489 110319270
Neck pain 23.74 10.14 189 269351 122941 110196818
Diffuse large B-cell lymphoma refractory 23.72 10.14 30 269510 2491 110317268
Urticaria 23.57 10.14 594 268946 318263 110001496
Pneumococcal sepsis 23.52 10.14 28 269512 2184 110317575
Genital herpes 23.47 10.14 30 269510 2517 110317242
Neutrophil percentage decreased 23.43 10.14 19 269521 924 110318835
Platelet count abnormal 23.31 10.14 49 269491 6233 110313526
Mucosal disorder 23.27 10.14 40 269500 4377 110315382
Pulmonary arterial hypertension 23.27 10.14 27 269513 32541 110287218
Primary adrenal insufficiency 23.17 10.14 16 269524 608 110319151
Cardio-respiratory arrest 23.17 10.14 176 269364 115660 110204099
Somnolence 23.11 10.14 550 268990 296899 110022860
Primary myelofibrosis 23.11 10.14 11 269529 202 110319557
Cytokine storm 23.09 10.14 23 269517 1467 110318292
Flushing 23.00 10.14 371 269169 104365 110215394
Monocyte count increased 22.93 10.14 78 269462 13215 110306544
Cerebral toxoplasmosis 22.86 10.14 33 269507 3109 110316650
Blood brain barrier defect 22.86 10.14 11 269529 207 110319552
Klebsiella test positive 22.84 10.14 29 269511 2417 110317342
Myocardial infarction 22.79 10.14 330 269210 191753 110128006
Haemorrhagic disorder 22.75 10.14 25 269515 1788 110317971
Hyperplasia 22.73 10.14 23 269517 1495 110318264
Obliterative bronchiolitis 22.69 10.14 36 269504 3687 110316072
Red blood cell count increased 22.65 10.14 42 269498 4876 110314883
Blood urea increased 22.63 10.14 219 269321 54738 110265021
Human chorionic gonadotropin increased 22.55 10.14 23 269517 1509 110318250
Tri-iodothyronine free decreased 22.50 10.14 14 269526 445 110319314
CNS ventriculitis 22.47 10.14 16 269524 639 110319120
Oesophagitis 22.39 10.14 133 269407 28582 110291177
Abdominal pain 22.34 10.14 1022 268518 511967 109807792
Strongyloidiasis 22.24 10.14 42 269498 4944 110314815
Blood pressure diastolic increased 22.19 10.14 9 269531 18798 110300961
Porphyria acute 22.14 10.14 9 269531 18771 110300988
Meningoencephalitis bacterial 22.14 10.14 14 269526 458 110319301
Seronegative arthritis 22.01 10.14 3 269537 13174 110306585
Forced expiratory volume decreased 22.00 10.14 3 269537 13173 110306586
Disseminated toxoplasmosis 22.00 10.14 14 269526 463 110319296
Myelocyte percentage increased 21.99 10.14 11 269529 226 110319533
Respiratory tract infection viral 21.99 10.14 46 269494 5832 110313927
Monoclonal immunoglobulin present 21.98 10.14 29 269511 2511 110317248
Pneumonia parainfluenzae viral 21.91 10.14 16 269524 665 110319094
Mean cell haemoglobin concentration decreased 21.88 10.14 45 269495 5637 110314122
Herpes simplex pneumonia 21.86 10.14 13 269527 380 110319379
Blood parathyroid hormone decreased 21.81 10.14 3 269537 13086 110306673
Blood creatinine decreased 21.74 10.14 60 269480 9077 110310682
Dyslipidaemia 21.70 10.14 6 269534 15959 110303800
Device expulsion 21.65 10.14 26 269514 30865 110288894
Meningitis candida 21.65 10.14 11 269529 234 110319525
Chimerism 21.55 10.14 12 269528 309 110319450
Pneumonia klebsiella 21.51 10.14 49 269491 6583 110313176
Nephropathy 21.48 10.14 77 269463 13390 110306369
Urinary tract infection enterococcal 21.47 10.14 35 269505 3667 110316092
Viraemia 21.42 10.14 37 269503 4065 110315694
Muscle spasticity 21.39 10.14 34 269506 35881 110283878
Dermatitis bullous 21.30 10.14 92 269448 17437 110302322
Nodule 21.28 10.14 29 269511 32602 110287157
Personality disorder 21.26 10.14 3 269537 12834 110306925
Varicella zoster pneumonia 21.24 10.14 13 269527 401 110319358
Hyperpyrexia 21.23 10.14 55 269485 8014 110311745
Marrow hyperplasia 21.22 10.14 24 269516 1772 110317987
Amyloidosis 21.12 10.14 32 269508 3149 110316610
Ventricular fibrillation 21.11 10.14 43 269497 41270 110278489
Herpes zoster meningitis 21.11 10.14 11 269529 247 110319512
Pneumonitis 21.10 10.14 282 269258 76249 110243510
Spinal fracture 21.09 10.14 110 269430 22523 110297236
Polyneuropathy 21.06 10.14 142 269398 31870 110287889
Mean cell haemoglobin increased 21.06 10.14 44 269496 5573 110314186
Mesangioproliferative glomerulonephritis 21.03 10.14 11 269529 249 110319510
Metastases to central nervous system 20.96 10.14 15 269525 22802 110296957
Diabetes mellitus inadequate control 20.93 10.14 25 269515 29750 110290009
Autoimmune haemolytic anaemia 20.93 10.14 65 269475 10502 110309257
Partial seizures 20.83 10.14 68 269472 11281 110308478
Lymph node palpable 20.75 10.14 10 269530 189 110319570
Blood pressure systolic abnormal 20.73 10.14 18 269522 24832 110294927
Acquired macroglossia 20.72 10.14 11 269529 257 110319502
Injection site urticaria 20.70 10.14 8 269532 17207 110302552
Mean cell volume decreased 20.61 10.14 44 269496 5658 110314101
Extrapyramidal disorder 20.55 10.14 24 269516 28843 110290916
Muscle rigidity 20.55 10.14 17 269523 24014 110295745
Full blood count increased 20.54 10.14 16 269524 734 110319025
Focal myositis 20.52 10.14 6 269534 24 110319735
Substance abuse 20.43 10.14 3 269537 12460 110307299
Melaena 20.42 10.14 92 269448 68665 110251094
Procalcitonin increased 20.41 10.14 36 269504 4020 110315739
Transfusion-related acute lung injury 20.37 10.14 13 269527 432 110319327
Arterial occlusive disease 20.35 10.14 6 269534 15302 110304457
Pneumaturia 20.23 10.14 7 269533 53 110319706
Depressed mood 20.15 10.14 78 269462 60731 110259028
Cytomegalovirus mucocutaneous ulcer 20.14 10.14 9 269531 142 110319617
Pulmonary oedema 20.07 10.14 351 269189 100308 110219451
Metapneumovirus pneumonia 19.97 10.14 10 269530 206 110319553
Candida sepsis 19.96 10.14 30 269510 2931 110316828
Parkinsonism 19.84 10.14 15 269525 22172 110297587
Chronic lymphocytic leukaemia transformation 19.80 10.14 11 269529 282 110319477
Myelocyte count increased 19.78 10.14 17 269523 897 110318862
Metapneumovirus infection 19.76 10.14 27 269513 2417 110317342
Pulmonary haemorrhage 19.71 10.14 86 269454 16370 110303389
Bone pain 19.64 10.14 244 269296 64889 110254870
Hiatus hernia 19.60 10.14 23 269517 27583 110292176
Splenic embolism 19.54 10.14 10 269530 216 110319543
Human polyomavirus infection 19.47 10.14 23 269517 1779 110317980
Dysgeusia 19.35 10.14 258 269282 69727 110250032
Pericardial effusion 19.31 10.14 219 269321 56998 110262761
Thyroxine free decreased 19.21 10.14 19 269521 1201 110318558
Ear infection 19.20 10.14 83 269457 62649 110257110
Cardiac murmur 19.17 10.14 19 269521 24609 110295150
Immunosuppression 19.17 10.14 90 269450 17669 110302090
Oroantral fistula 18.96 10.14 12 269528 393 110319366
Liver function test increased 18.94 10.14 132 269408 88416 110231343
Hepatitis B 18.92 10.14 59 269481 9553 110310206
Dilatation intrahepatic duct acquired 18.90 10.14 16 269524 827 110318932
Protein total increased 18.89 10.14 38 269502 4686 110315073
Cyanosis 18.83 10.14 27 269513 29714 110290045
Enamel anomaly 18.82 10.14 10 269530 234 110319525
Pulpitis dental 18.81 10.14 21 269519 1528 110318231
Lymphocytosis 18.69 10.14 41 269499 5370 110314389
Factor XIII Inhibition 18.67 10.14 6 269534 35 110319724
Haemolytic uraemic syndrome 18.63 10.14 39 269501 4946 110314813
Euglycaemic diabetic ketoacidosis 18.59 10.14 3 269537 11620 110308139
Adenomatous polyposis coli 18.58 10.14 11 269529 319 110319440
Gastritis fungal 18.58 10.14 11 269529 319 110319440
Human herpesvirus 6 infection reactivation 18.56 10.14 18 269522 1111 110318648
IgA nephropathy 18.40 10.14 30 269510 3143 110316616
Metabolic acidosis 18.36 10.14 155 269385 99589 110220170
Arteritis infective 18.35 10.14 9 269531 177 110319582
Red blood cell elliptocytes present 18.35 10.14 9 269531 177 110319582
Pneumocystis jirovecii infection 18.32 10.14 36 269504 4364 110315395
Reticulocytosis 18.28 10.14 14 269526 626 110319133
Serotonin syndrome 18.27 10.14 78 269462 59075 110260684
Colitis microscopic 18.27 10.14 5 269535 13389 110306370
Platelet distribution width decreased 18.25 10.14 6 269534 38 110319721
Hyperuricaemia 18.22 10.14 77 269463 14454 110305305
Aphasia 18.22 10.14 222 269318 58775 110260984
Breath sounds abnormal 18.21 10.14 21 269519 25383 110294376
Cytomegalovirus enterocolitis 18.14 10.14 25 269515 2256 110317503
Angina pectoris 18.12 10.14 84 269456 62211 110257548
Pyogenic granuloma 18.03 10.14 13 269527 530 110319229
Encephalomyelitis 18.01 10.14 11 269529 338 110319421
Device related sepsis 17.98 10.14 50 269490 7597 110312162
Haemophilus sepsis 17.97 10.14 10 269530 257 110319502
Myalgia 17.88 10.14 409 269131 221972 110097787
Myeloblast percentage decreased 17.87 10.14 6 269534 41 110319718
Pulmonary mucormycosis 17.82 10.14 24 269516 2119 110317640
Ear pain 17.81 10.14 68 269472 53158 110266601
Chest pain 17.79 10.14 743 268797 375632 109944127
Herpes simplex meningoencephalitis 17.69 10.14 7 269533 80 110319679
Hypoalbuminaemia 17.58 10.14 126 269414 28848 110290911
Sinusitis fungal 17.55 10.14 27 269513 2693 110317066
Panniculitis 17.52 10.14 8 269532 15574 110304185
Respiratory depression 17.49 10.14 32 269508 31969 110287790
Crystal nephropathy 17.32 10.14 22 269518 1834 110317925
Hypouricaemia 17.30 10.14 13 269527 565 110319194
Light chain disease 17.24 10.14 10 269530 279 110319480
Mitochondrial DNA mutation 17.20 10.14 12 269528 464 110319295
Accessory spleen 17.19 10.14 9 269531 204 110319555
Tendonitis 17.19 10.14 23 269517 26060 110293699
Exposure to toxic agent 17.16 10.14 5 269535 12853 110306906
Tooth disorder 17.14 10.14 127 269413 29382 110290377
Delayed engraftment 17.14 10.14 10 269530 282 110319477
Brain herniation 17.08 10.14 54 269486 8809 110310950
Immune recovery uveitis 17.05 10.14 8 269532 142 110319617
Tachycardia 17.04 10.14 695 268845 225950 110093809
Hip fracture 16.98 10.14 145 269395 35006 110284753
Muscle spasms 16.97 10.14 835 268705 277322 110042437
Infected neoplasm 16.96 10.14 13 269527 582 110319177
CSF cell count increased 16.95 10.14 8 269532 144 110319615
Petechiae 16.91 10.14 106 269434 23211 110296548
Ulcer haemorrhage 16.91 10.14 18 269522 22553 110297206
Abdominal wall wound 16.88 10.14 7 269533 91 110319668
Gastroenteritis norovirus 16.83 10.14 31 269509 3580 110316179
Transfusion reaction 16.81 10.14 23 269517 2062 110317697
Cytomegalovirus oesophagitis 16.74 10.14 16 269524 970 110318789
Follicular mucinosis 16.72 10.14 5 269535 22 110319737
Arteriosclerosis coronary artery 16.71 10.14 22 269518 25096 110294663
Graft complication 16.67 10.14 17 269523 1115 110318644
Withdrawal syndrome 16.60 10.14 32 269508 31348 110288411
Paranoia 16.58 10.14 18 269522 22356 110297403
Eosinophilic granulomatosis with polyangiitis 16.56 10.14 3 269537 10683 110309076
Device related infection 16.52 10.14 158 269382 39361 110280398
Body temperature increased 16.52 10.14 205 269335 54508 110265251
Vaginal cellulitis 16.48 10.14 7 269533 97 110319662
Metastases to lymph nodes 16.47 10.14 8 269532 15024 110304735
Embolism 16.46 10.14 81 269459 16208 110303551
Pneumonia pseudomonal 16.44 10.14 48 269492 7498 110312261
Acanthamoeba infection 16.43 10.14 13 269527 610 110319149
Abortion spontaneous 16.42 10.14 37 269503 34245 110285514
Premature delivery 16.42 10.14 31 269509 30601 110289158
Enthesopathy 16.39 10.14 5 269535 12473 110307286
T-lymphocyte count decreased 16.38 10.14 13 269527 613 110319146
Hepatitis fulminant 16.35 10.14 52 269488 8508 110311251
Herpes simplex reactivation 16.30 10.14 19 269521 1449 110318310
Gingivitis ulcerative 16.24 10.14 12 269528 508 110319251
Myositis 16.23 10.14 32 269508 31084 110288675
Klebsiella sepsis 16.12 10.14 33 269507 4120 110315639
Rash papular 16.08 10.14 119 269421 27520 110292239
Escherichia urinary tract infection 16.07 10.14 80 269460 16082 110303677
Pneumonia cryptococcal 16.07 10.14 25 269515 2517 110317242
Corneal thickening 16.04 10.14 5 269535 26 110319733
Hypoglossal nerve paralysis 16.04 10.14 5 269535 26 110319733
Ecthyma 16.03 10.14 16 269524 1023 110318736
Pulmonary sepsis 16.03 10.14 38 269502 5240 110314519
Actinomycosis 15.99 10.14 18 269522 1322 110318437
Cytomegalovirus hepatitis 15.95 10.14 15 269525 891 110318868
Renal oncocytoma 15.91 10.14 9 269531 239 110319520
Spondylitis 15.90 10.14 4 269536 11334 110308425
Hallucination, visual 15.90 10.14 157 269383 39448 110280311
Chronic obstructive pulmonary disease 15.73 10.14 180 269360 108978 110210781
Superinfection bacterial 15.72 10.14 24 269516 2377 110317382
Respiratory acidosis 15.70 10.14 7 269533 13819 110305940
Rash papulosquamous 15.67 10.14 8 269532 172 110319587
Walking aid user 15.64 10.14 23 269517 25052 110294707
Brain abscess 15.64 10.14 44 269496 6730 110313029
Leukaemia 15.60 10.14 47 269493 7471 110312288
Cellulitis 15.59 10.14 410 269130 125606 110194153
Viral infection 15.57 10.14 198 269342 52941 110266818
Cytomegalovirus colitis 15.46 10.14 45 269495 7016 110312743
Macular degeneration 15.43 10.14 18 269522 21641 110298118
Renal tubular necrosis 15.40 10.14 127 269413 30348 110289411
Glomerulonephritis minimal lesion 15.37 10.14 16 269524 1075 110318684
Drug level increased 15.37 10.14 181 269359 47538 110272221
Temperature regulation disorder 15.36 10.14 6 269534 12820 110306939
Tooth hypoplasia 15.29 10.14 10 269530 347 110319412
Interstitial lung disease 15.28 10.14 243 269297 139091 110180668
Hepatosplenomegaly 15.06 10.14 44 269496 6875 110312884
CSF lactate increased 15.06 10.14 3 269537 0 110319759
Mononuclear cell count increased 15.06 10.14 3 269537 0 110319759
Granulocyte percentage 15.05 10.14 6 269534 70 110319689
Neuralgic amyotrophy 15.04 10.14 10 269530 357 110319402
Creatinine urine decreased 14.96 10.14 10 269530 360 110319399
Atrioventricular block first degree 14.94 10.14 8 269532 14217 110305542
Neutrophil morphology abnormal 14.93 10.14 7 269533 124 110319635
Disseminated varicella zoster virus infection 14.93 10.14 17 269523 1264 110318495
Blood thyroid stimulating hormone abnormal 14.92 10.14 16 269524 1113 110318646
Haematuria traumatic 14.84 10.14 10 269530 365 110319394
Pancreatic abscess 14.83 10.14 8 269532 193 110319566
Paraesthesia oral 14.81 10.14 38 269502 33633 110286126
Corneal deposits 14.79 10.14 12 269528 584 110319175
Nocardiosis 14.78 10.14 46 269494 7440 110312319
Soft tissue infection 14.68 10.14 36 269504 5071 110314688
Anti-thyroid antibody 14.66 10.14 5 269535 36 110319723
Urine bilirubin increased 14.59 10.14 7 269533 131 110319628
Poikiloderma 14.58 10.14 11 269529 481 110319278
Treatment noncompliance 14.55 10.14 111 269429 72879 110246880
Fumbling 14.54 10.14 7 269533 132 110319627
Incorrect dose administered 14.51 10.14 172 269368 103469 110216290
Actinomycotic sepsis 14.51 10.14 8 269532 202 110319557
Target skin lesion 14.49 10.14 9 269531 285 110319474
Oesophageal carcinoma 14.46 10.14 5 269535 11519 110308240
Proctitis 14.44 10.14 12 269528 16915 110302844
Viral load increased 14.44 10.14 28 269512 3362 110316397
Ophthalmic herpes zoster 14.41 10.14 28 269512 3367 110316392
Exposure via skin contact 14.40 10.14 7 269533 13140 110306619
Achromobacter infection 14.38 10.14 9 269531 289 110319470
Sputum discoloured 14.35 10.14 29 269511 27916 110291843
Carotid artery thrombosis 14.32 10.14 3 269537 9635 110310124
Eye infection fungal 14.29 10.14 12 269528 613 110319146
Haemophilus infection 14.28 10.14 25 269515 2775 110316984
Postural tremor 14.18 10.14 15 269525 1027 110318732
Hypercalcaemia 14.16 10.14 175 269365 46482 110273277
White blood cell count abnormal 14.15 10.14 43 269497 6866 110312893
Gamma-glutamyltransferase increased 14.15 10.14 219 269321 61090 110258669
Fungal sepsis 14.14 10.14 22 269518 2215 110317544
Device breakage 14.09 10.14 8 269532 13761 110305998
Anal ulcer 14.09 10.14 20 269520 1856 110317903
Citrobacter infection 14.09 10.14 17 269523 1345 110318414
Vision blurred 14.06 10.14 413 269127 128609 110191150
CSF test abnormal 14.01 10.14 13 269527 759 110319000
Pregnancy of partner 14 10.14 9 269531 303 110319456
Antinuclear antibody negative 13.90 10.14 7 269533 146 110319613
Movement disorder 13.87 10.14 44 269496 36360 110283399
Myelosuppression 13.82 10.14 155 269385 94185 110225574
Coombs direct test positive 13.80 10.14 11 269529 522 110319237
Fear 13.77 10.14 22 269518 23171 110296588
Hiccups 13.73 10.14 65 269475 12804 110306955
Tooth deposit 13.72 10.14 9 269531 314 110319445
Electrocardiogram QT prolonged 13.70 10.14 185 269355 108775 110210984
Cellulitis staphylococcal 13.68 10.14 17 269523 1386 110318373
Dermatitis exfoliative generalised 13.65 10.14 58 269482 10914 110308845
T-cell lymphoma 13.64 10.14 18 269522 1558 110318201
Iron deficiency anaemia 13.59 10.14 36 269504 31523 110288236
Hepatitis 13.57 10.14 147 269393 89907 110229852
Peripheral arterial occlusive disease 13.56 10.14 3 269537 9277 110310482
Haematopoietic stem cell mobilisation 13.54 10.14 10 269530 423 110319336
Gastrointestinal stromal tumour 13.53 10.14 21 269519 2110 110317649
Ear swelling 13.50 10.14 21 269519 2115 110317644
Monocyte percentage decreased 13.44 10.14 9 269531 325 110319434
Keratic precipitates 13.39 10.14 11 269529 545 110319214
Avulsion fracture 13.37 10.14 9 269531 328 110319431
Fat necrosis 13.36 10.14 14 269526 948 110318811
Haemorrhagic occlusive retinal vasculitis 13.35 10.14 6 269534 96 110319663
Tenosynovitis 13.34 10.14 12 269528 16271 110303488
Ketoacidosis 13.32 10.14 4 269536 10083 110309676
Blood alkaline phosphatase increased 13.31 10.14 245 269295 70690 110249069
Post-depletion B-cell recovery 13.30 10.14 4 269536 18 110319741
Aggression 13.29 10.14 87 269453 59123 110260636
Systemic inflammatory response syndrome 13.28 10.14 65 269475 12978 110306781
B-cell lymphoma 13.25 10.14 43 269497 7111 110312648
Blood phosphorus decreased 13.24 10.14 45 269495 7620 110312139
Sideroblastic anaemia 13.22 10.14 10 269530 439 110319320
Adenoviral haemorrhagic cystitis 13.20 10.14 12 269528 682 110319077
Amylase increased 13.19 10.14 63 269477 12456 110307303
Duodenal stenosis 13.18 10.14 14 269526 963 110318796
Pancreatitis 13.18 10.14 155 269385 93378 110226381
Hepatic encephalopathy 13.13 10.14 31 269509 28225 110291534
Middle ear inflammation 13.12 10.14 8 269532 245 110319514
Polyp 13.10 10.14 4 269536 9976 110309783
Gastrooesophageal reflux disease 13.10 10.14 336 269204 179640 110140119
Tri-iodothyronine free abnormal 13.06 10.14 5 269535 52 110319707
Potentiating drug interaction 13.06 10.14 6 269534 11637 110308122
Device dislocation 13.03 10.14 37 269503 31667 110288092
Hepatitis viral 13.01 10.14 17 269523 1458 110318301
Pathological fracture 13.01 10.14 61 269479 11971 110307788
Graft versus host disease in eye 13.00 10.14 10 269530 450 110319309
Hypercreatininaemia 12.99 10.14 16 269524 1293 110318466
Hepatitis B reactivation 12.99 10.14 44 269496 7440 110312319
Catheter site infection 12.98 10.14 46 269494 7954 110311805
Transaminases increased 12.98 10.14 222 269318 63168 110256591
Oesophagopleural fistula 12.97 10.14 5 269535 53 110319706
Alveolitis necrotising 12.96 10.14 4 269536 20 110319739
Infection 12.95 10.14 1038 268502 361162 109958597
Erythema multiforme 12.95 10.14 92 269448 21005 110298754
Tachypnoea 12.94 10.14 150 269390 39245 110280514
Craniocervical syndrome 12.92 10.14 6 269534 104 110319655
Injection site warmth 12.90 10.14 14 269526 17391 110302368
Gingival oedema 12.87 10.14 6 269534 105 110319654
Thyroid stimulating immunoglobulin increased 12.86 10.14 7 269533 172 110319587
Immature granulocyte count increased 12.86 10.14 13 269527 844 110318915
Respiratory tract infection fungal 12.84 10.14 16 269524 1308 110318451
Lung neoplasm malignant 12.83 10.14 41 269499 33801 110285958
Dissociation 12.82 10.14 4 269536 9838 110309921
Central nervous system lymphoma 12.79 10.14 25 269515 3019 110316740
Splenic infarction 12.75 10.14 31 269509 4343 110315416
Cytomegalovirus gastroenteritis 12.74 10.14 12 269528 714 110319045
Neuromyotonia 12.71 10.14 6 269534 108 110319651
Coronary artery stenosis 12.70 10.14 9 269531 13749 110306010
Retinal depigmentation 12.70 10.14 9 269531 357 110319402
Nasal congestion 12.67 10.14 166 269374 98116 110221643
Failure to thrive 12.67 10.14 66 269474 13508 110306251
General symptom 12.64 10.14 3 269537 8843 110310916
Drug-induced liver injury 12.64 10.14 211 269329 119856 110199903
Upper respiratory tract infection 12.62 10.14 414 269126 130914 110188845
Skin haemorrhage 12.55 10.14 26 269514 24801 110294958
Viral mutation identified 12.54 10.14 31 269509 4388 110315371
Gardnerella test positive 12.53 10.14 3 269537 4 110319755
Defaecation urgency 12.44 10.14 3 269537 8744 110311015
Eosinophil percentage decreased 12.43 10.14 9 269531 369 110319390
Hepatic failure 12.41 10.14 236 269304 68503 110251256
Hypothyroidism 12.39 10.14 248 269292 72651 110247108
Tardive dyskinesia 12.38 10.14 9 269531 13570 110306189
Pemphigoid 12.37 10.14 18 269522 19689 110300070
Nitrite urine 12.35 10.14 4 269536 24 110319735
Aspergillus test positive 12.35 10.14 14 269526 1036 110318723
Gastrointestinal infection 12.32 10.14 67 269473 13938 110305821
Necrotising herpetic retinopathy 12.30 10.14 7 269533 188 110319571
Injection site rash 12.29 10.14 24 269516 23395 110296364
Carotid artery occlusion 12.26 10.14 4 269536 9561 110310198
Infection in an immunocompromised host 12.25 10.14 19 269521 1908 110317851
Pollakiuria 12.24 10.14 163 269377 44032 110275727
Cerebral artery stenosis 12.24 10.14 13 269527 894 110318865
Haematocrit increased 12.23 10.14 33 269507 4926 110314833
Bradypnoea 12.23 10.14 3 269537 8646 110311113
Asphyxia 12.22 10.14 10 269530 14205 110305554
Myasthenia gravis 12.22 10.14 21 269519 21490 110298269
Aplasia pure red cell 12.20 10.14 51 269489 9527 110310232
Disorientation 12.20 10.14 241 269299 70430 110249329
Agranulocytosis 12.18 10.14 215 269325 61545 110258214
Liver disorder 12.18 10.14 259 269281 141984 110177775
Alpha haemolytic streptococcal infection 12.16 10.14 27 269513 3566 110316193
Meningism 12.16 10.14 12 269528 757 110319002
Lymphoplasmacytoid lymphoma/immunocytoma 12.13 10.14 5 269535 64 110319695
Glomerulonephritis chronic 12.04 10.14 8 269532 285 110319474
Complications of transplant surgery 12.02 10.14 12 269528 767 110318992
Meningitis enterococcal 12.01 10.14 7 269533 197 110319562
Pancreatitis necrotising 11.99 10.14 35 269505 5466 110314293
False negative investigation result 11.96 10.14 9 269531 392 110319367
Poisoning 11.94 10.14 34 269506 29071 110290688
Fall 11.93 10.14 1288 268252 602194 109717565
Tonsillar haemorrhage 11.92 10.14 8 269532 290 110319469
Haemolysis 11.91 10.14 72 269468 15567 110304192
Osteolysis 11.91 10.14 35 269505 5488 110314271
Psychotic disorder 11.87 10.14 74 269466 50863 110268896
Steroid dependence 11.86 10.14 3 269537 8466 110311293
Angioimmunoblastic T-cell lymphoma 11.84 10.14 11 269529 643 110319116
Adrenal insufficiency 11.83 10.14 58 269482 42332 110277427
Campylobacter infection 11.83 10.14 21 269519 2358 110317401
Bacillus infection 11.82 10.14 17 269523 1597 110318162
Product complaint 11.80 10.14 10 269530 13962 110305797
Respiratory disorder 11.79 10.14 114 269426 71268 110248491
Paternal exposure timing unspecified 11.79 10.14 5 269535 69 110319690
JC virus CSF test positive 11.79 10.14 7 269533 204 110319555
Foetal death 11.79 10.14 13 269527 16032 110303727
Bone density decreased 11.79 10.14 13 269527 16029 110303730
Dermatitis allergic 11.78 10.14 92 269448 21632 110298127
Newcastle disease 11.78 10.14 3 269537 6 110319753
Skin lesion 11.75 10.14 184 269356 51447 110268312
Antineutrophil cytoplasmic antibody positive 11.75 10.14 33 269507 5043 110314716
Generalised tonic-clonic seizure 11.75 10.14 193 269347 54487 110265272
Product prescribing error 11.74 10.14 75 269465 51256 110268503
Glycosylated haemoglobin increased 11.72 10.14 25 269515 23594 110296165
Eczema 11.72 10.14 116 269424 72177 110247582
Atelectasis 11.71 10.14 139 269401 36573 110283186
Glomerulosclerosis 11.70 10.14 15 269525 1262 110318497
Meningitis viral 11.70 10.14 21 269519 2378 110317381
Graft versus host disease in lung 11.69 10.14 15 269525 1263 110318496
Incorrect product administration duration 11.65 10.14 20 269520 20478 110299281
Immunosuppressant drug level increased 11.64 10.14 58 269482 11666 110308093
Skin discolouration 11.63 10.14 176 269364 48870 110270889
Chronic graft versus host disease in skin 11.61 10.14 22 269518 2597 110317162
Blood culture positive 11.60 10.14 48 269492 8928 110310831
Gastrointestinal candidiasis 11.60 10.14 10 269530 530 110319229
Aspartate aminotransferase 11.53 10.14 13 269527 956 110318803
Generalised oedema 11.50 10.14 120 269420 30584 110289175
Cranial nerve paralysis 11.49 10.14 9 269531 416 110319343
Thrombophlebitis 11.49 10.14 43 269497 7636 110312123
Immune system disorder 11.48 10.14 64 269476 13437 110306322
Viral oesophagitis 11.46 10.14 3 269537 7 110319752
Renal cancer 11.42 10.14 9 269531 13025 110306734
Dizziness 11.42 10.14 1509 268031 696684 109623075
Herpes zoster reactivation 11.40 10.14 9 269531 421 110319338
Prostate cancer 11.40 10.14 50 269490 37591 110282168
Mean platelet volume decreased 11.40 10.14 25 269515 3275 110316484
Endotoxic shock 11.37 10.14 4 269536 32 110319727
Adenocarcinoma of colon 11.36 10.14 37 269503 6131 110313628
Coronary artery occlusion 11.35 10.14 13 269527 15759 110304000
Pulmonary toxicity 11.34 10.14 16 269524 17730 110302029
Injection site discolouration 11.34 10.14 4 269536 9099 110310660
Vitreous detachment 11.34 10.14 22 269518 2643 110317116
Testicular swelling 11.33 10.14 17 269523 1659 110318100
Opportunistic infection 11.29 10.14 26 269514 3517 110316242
Therapy interrupted 11.29 10.14 73 269467 49749 110270010
SARS-CoV-2 RNA 11.26 10.14 4 269536 33 110319726
Retching 11.26 10.14 24 269516 22658 110297101
Infrapatellar fat pad inflammation 11.21 10.14 7 269533 224 110319535
Abdominal distension 11.17 10.14 333 269207 174770 110144989
Alcohol poisoning 11.17 10.14 4 269536 9016 110310743
Semenuria 11.16 10.14 4 269536 34 110319725
Immature granulocyte percentage increased 11.13 10.14 5 269535 80 110319679
Palpitations 11.12 10.14 299 269241 158913 110160846
Injection site induration 11.11 10.14 7 269533 11376 110308383
Areflexia 11.05 10.14 39 269501 6730 110313029
Progressive multifocal leukoencephalopathy 11.05 10.14 101 269439 24855 110294904
Hyperhidrosis 11.02 10.14 360 269180 186938 110132821
Thunderclap headache 11.01 10.14 10 269530 568 110319191
Candida test positive 11.00 10.14 15 269525 1340 110318419
Asterixis 10.99 10.14 24 269516 3134 110316625
Respiratory tract infection 10.98 10.14 240 269300 71377 110248382
Blood gases abnormal 10.98 10.14 15 269525 1343 110318416
Leukoencephalopathy 10.97 10.14 48 269492 9147 110310612
Fear of injection 10.95 10.14 4 269536 8907 110310852
Scrotal pain 10.93 10.14 10 269530 573 110319186
Product administration error 10.93 10.14 50 269490 37167 110282592
Bilirubin urine 10.92 10.14 3 269537 9 110319750
Multiple drug therapy 10.91 10.14 3 269537 8011 110311748
Ureaplasma infection 10.91 10.14 16 269524 1530 110318229
Right ventricular failure 10.88 10.14 30 269510 25924 110293835
Hyperkalaemia 10.84 10.14 250 269290 135546 110184213
Dysbiosis 10.83 10.14 19 269521 2113 110317646
Haemoglobin urine 10.83 10.14 6 269534 153 110319606
Staphylococcus test positive 10.80 10.14 41 269499 7329 110312430
Injection site phlebitis 10.79 10.14 6 269534 154 110319605
Multiple-drug resistance 10.77 10.14 62 269478 13173 110306586
Coronavirus infection 10.77 10.14 49 269491 9496 110310263
Candida pneumonia 10.76 10.14 13 269527 1030 110318729
Gene mutation 10.75 10.14 25 269515 3404 110316355
Pneumococcal bacteraemia 10.75 10.14 7 269533 241 110319518
Refractoriness to platelet transfusion 10.75 10.14 7 269533 241 110319518
Visceral leishmaniasis 10.73 10.14 17 269523 1739 110318020
Lactose intolerance 10.71 10.14 22 269518 2754 110317005
Neurological decompensation 10.68 10.14 39 269501 6844 110312915
Platelet disorder 10.67 10.14 26 269514 3649 110316110
Drug therapeutic incompatibility 10.65 10.14 6 269534 158 110319601
Nystagmus 10.60 10.14 56 269484 11521 110308238
Salmonella test positive 10.59 10.14 5 269535 90 110319669
Spinal compression fracture 10.59 10.14 79 269461 18313 110301446
CSF glucose decreased 10.58 10.14 6 269534 160 110319599
Disseminated strongyloidiasis 10.56 10.14 10 269530 599 110319160
Jaundice cholestatic 10.56 10.14 12 269528 14596 110305163
Epistaxis 10.54 10.14 403 269137 129969 110189790
Iron deficiency 10.53 10.14 18 269522 18458 110301301
Spinal cord injury thoracic 10.42 10.14 6 269534 165 110319594
Caesarean section 10.37 10.14 11 269529 13806 110305953
Myocardial oedema 10.37 10.14 10 269530 613 110319146
Hypoproteinaemia 10.36 10.14 35 269505 5910 110313849
Hypomania 10.35 10.14 6 269534 10204 110309555
Mean cell volume increased 10.34 10.14 44 269496 8286 110311473
Post procedural complication 10.31 10.14 32 269508 26626 110293133
Cataract subcapsular 10.30 10.14 14 269526 1247 110318512
Babesiosis 10.29 10.14 9 269531 486 110319273
Choking 10.29 10.14 13 269527 15097 110304662
Hyperglycaemia 10.28 10.14 276 269264 84814 110234945
Postoperative wound infection 10.27 10.14 14 269526 15739 110304020
Impaired quality of life 10.27 10.14 38 269502 29979 110289780
Blood glucose fluctuation 10.26 10.14 3 269537 7695 110312064
Listeria test positive 10.26 10.14 3 269537 12 110319747
Papillary serous endometrial carcinoma 10.26 10.14 3 269537 12 110319747
Proctitis herpes 10.26 10.14 3 269537 12 110319747
Liver function test 10.26 10.14 6 269534 170 110319589
Molluscum contagiosum 10.25 10.14 10 269530 622 110319137
Duodenal ulcer 10.24 10.14 20 269520 19494 110300265
Oesophageal infection 10.24 10.14 11 269529 767 110318992
Streptococcal infection 10.20 10.14 53 269487 10837 110308922
Transplant 10.19 10.14 14 269526 1260 110318499
Acquired diaphragmatic eventration 10.19 10.14 11 269529 771 110318988
Product dispensing error 10.19 10.14 15 269525 16330 110303429
Gangrene 10.18 10.14 15 269525 16326 110303433
Nephrogenic diabetes insipidus 10.18 10.14 20 269520 2425 110317334
Increased tendency to bruise 10.18 10.14 56 269484 11702 110308057
Fluid retention 10.17 10.14 165 269375 94142 110225617
Transplant rejection 10.16 10.14 98 269442 24469 110295290

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 49.71 37.91 32 172 1601 112148

Pharmacologic Action:

SourceCodeDescription
ATC D06BB03 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Antivirals
ATC D06BB53 DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Antivirals
ATC J05AB01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
ATC S01AD03 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antivirals
FDA MoA N0000020060 DNA Polymerase Inhibitors
FDA EXT N0000175459 Nucleoside Analog
FDA EPC N0000175468 Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:36044 antiviral drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64952 anti-HSV agent
CHEBI has role CHEBI:66981 ophthalmology drug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
FDA EPC N0000180187 Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor
FDA EPC N0000180188 Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

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berdazimerdocosanoledoxudineibacitabineidoxuridineimiquimodinosinepenciclovirpodophyllotoxinsinecatechinstromantadine
J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors 11 drugs
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Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Herpes labialis indication 1475003
Herpes zoster indication 4740000 DOID:8536
Genital herpes simplex indication 33839006 DOID:8704
Varicella indication 38907003 DOID:8659
Herpes simplex indication 88594005 DOID:8566
Herpes simplex infection of skin indication 240475000
Recurrent herpes simplex labialis indication 402892009
Recurrent genital herpes simplex indication 402894005
Encephalitis due to Herpesvirus indication 428638009
Recurrent Mucocutaneous Herpes Simplex indication
Suppression of Recurrent Herpes Simplex Infection indication
Herpes zoster ophthalmicus off-label use 87513003
Granulomatosis Infantiseptica off-label use
Herpes Zoster Hepatitis off-label use
Neonatal Herpes Meningoencephalitis off-label use
Disseminated Herpes Simplex Neonatal Infection off-label use
Herpes Simplex Hepatitis off-label use
Prevention of Herpes Zoster in Immunocompromised Patient off-label use
Urinary tract obstruction contraindication 7163005 DOID:5200
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Diabetes mellitus contraindication 73211009 DOID:9351
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Hyperglycemia contraindication 80394007 DOID:4195
Kidney disease contraindication 90708001 DOID:557
Hemolytic uremic syndrome contraindication 111407006 DOID:12554
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Telangiectasia disorder contraindication 247479008
Pregnancy, function contraindication 289908002
Osteopenia contraindication 312894000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Cardiovascular event risk contraindication 395112001
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Obesity contraindication 414916001 DOID:9970
Smokes tobacco daily contraindication 449868002
Vertebral Metastases contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.97 acidic
pKa2 13.01 acidic
pKa3 3.83 Basic
pKa4 2.12 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
50MG SITAVIG LIGAND PHARMS N203791 April 12, 2013 DISCN TABLET BUCCAL 8791127 March 23, 2027 TREATMENT OF HERPES LABIALIS
50MG SITAVIG LIGAND PHARMS N203791 April 12, 2013 DISCN TABLET BUCCAL 8747896 June 3, 2027 TREATMENT OF HERPES LABIALIS
50MG SITAVIG LIGAND PHARMS N203791 April 12, 2013 DISCN TABLET BUCCAL 8592434 June 16, 2030 TREATMENT OF HERPES LABIALIS

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
3% **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** AVACLYR FERA PHARMS LLC N202408 March 29, 2019 DISCN OINTMENT OPHTHALMIC March 29, 2026 INDICATED FOR THE TREATMENT OF ACUTE HERPETIC KERATITIS (DENDRITIC ULCERS) IN PATIENTS WITH HERPES SIMPLEX (HSV-1 AND HSV-2) VIRUS

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Purine nucleoside phosphorylase Enzyme Ki 4.04 CHEMBL
DNA polymerase catalytic subunit Enzyme INHIBITOR DRUG LABEL DRUG LABEL
DNA polymerase catalytic subunit Enzyme INHIBITOR WOMBAT-PK DRUG LABEL
Thymidine kinase Kinase INHIBITOR WOMBAT-PK DRUG LABEL
Thymidine kinase Kinase INHIBITOR WOMBAT-PK DRUG LABEL
Thymidine kinase Kinase WOMBAT-PK
Purine nucleoside phosphorylase Enzyme Kd 4.90 CHEMBL

External reference:

IDSource
4018781 VUID
N0000147084 NUI
D00222 KEGG_DRUG
69657-51-8 SECONDARY_CAS_RN
152535 RXNORM
C0001367 UMLSCUI
CHEBI:2453 CHEBI
CHEMBL184 ChEMBL_ID
DB00787 DRUGBANK_ID
CHEMBL1200380 ChEMBL_ID
D000212 MESH_DESCRIPTOR_UI
135398513 PUBCHEM_CID
4435 INN_ID
X4HES1O11F UNII
14023 MMSL
1579 MMSL
4132 MMSL
4133 MMSL
981 MMSL
d00001 MMSL
AC2 PDB_CHEM_ID
4829 IUPHAR_LIGAND_ID
4018781 VANDF
4018782 VANDF
003016 NDDF
003017 NDDF
372729009 SNOMEDCT_US
41193000 SNOMEDCT_US
72387009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0093-3630 CREAM 50 mg TOPICAL NDA authorized generic 26 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0093-3630 CREAM 50 mg TOPICAL NDA authorized generic 26 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0143-9657 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 500 mg INTRAVENOUS ANDA 23 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0143-9658 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 g INTRAVENOUS ANDA 23 sections
Zovirax HUMAN PRESCRIPTION DRUG LABEL 1 0187-0993 OINTMENT 50 mg TOPICAL NDA 21 sections
Zovirax HUMAN PRESCRIPTION DRUG LABEL 1 0187-0994 CREAM 50 mg TOPICAL NDA 26 sections
Xerese HUMAN PRESCRIPTION DRUG LABEL 2 0187-5104 CREAM 50 mg TOPICAL NDA 26 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0440-7033 TABLET 800 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0472-0082 SUSPENSION 200 mg ORAL ANDA 19 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0591-1159 OINTMENT 50 mg TOPICAL NDA authorized generic 22 sections
ACYCLOVIR HUMAN PRESCRIPTION DRUG LABEL 1 0904-5789 CAPSULE 200 mg ORAL ANDA 21 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 0904-7507 TABLET 400 mg ORAL ANDA 19 sections
ACYCLOVIR HUMAN PRESCRIPTION DRUG LABEL 1 0904-7519 CAPSULE 200 mg ORAL ANDA 18 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-039 TABLET 400 mg ORAL ANDA 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-089 CAPSULE 200 mg ORAL ANDA 20 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-101 CAPSULE 200 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-102 TABLET 400 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 10544-103 TABLET 800 mg ORAL ANDA 22 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 12634-520 TABLET 400 mg ORAL ANDA 22 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 12634-697 TABLET 800 mg ORAL ANDA 22 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 13668-515 OINTMENT 50 mg TOPICAL ANDA 16 sections
ACYCLOVIR HUMAN PRESCRIPTION DRUG LABEL 1 16590-003 TABLET 800 mg ORAL ANDA 18 sections
ACYCLOVIR HUMAN PRESCRIPTION DRUG LABEL 1 16590-370 TABLET 400 mg ORAL ANDA 18 sections
acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 16714-885 OINTMENT 50 mg TOPICAL ANDA 19 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 17856-0083 SUSPENSION 200 mg ORAL ANDA 19 sections
Acyclovir suspension HUMAN PRESCRIPTION DRUG LABEL 1 17856-2170 SUSPENSION 200 mg ORAL ANDA 18 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 17856-8083 SUSPENSION 200 mg ORAL ANDA 19 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 21695-009 CAPSULE 200 mg ORAL ANDA 18 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 21695-010 TABLET 400 mg ORAL ANDA 18 sections
Acyclovir HUMAN PRESCRIPTION DRUG LABEL 1 21695-011 TABLET 800 mg ORAL NDA authorized generic 18 sections