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docosanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 940 | 661-19-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 57 | |||
| kinase-selectivity-class | ACVRL1,AKT2,AXL,CAMK2A,CAMK2D,CDK4,CSNK2A2,EIF2AK3,EPHB4,FLT4,GRK2,INSR,LRRK2,MAP2K6,MAPK10,MAPK12,MAPK8,MELK,MTOR,NUAK1,PDK4,PDPK1,PLK1,PLK2,PLK3,PLK4,PRKCD,PTK2,SIK2,STK33,TEK,TTK,ZAP70 | 33 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 25, 2000 | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Dysphoria | 73.20 | 46.76 | 17 | 1240 | 6137 | 90621053 |
| Appetite disorder | 66.53 | 46.76 | 17 | 1240 | 9116 | 90618074 |
| Haemorrhagic diathesis | 59.07 | 46.76 | 14 | 1243 | 5510 | 90621680 |
| Thinking abnormal | 57.68 | 46.76 | 16 | 1241 | 11716 | 90615474 |
| Skin warm | 54.47 | 46.76 | 14 | 1243 | 7673 | 90619517 |
| Arthritis infective | 53.93 | 46.76 | 14 | 1243 | 7978 | 90619212 |
| Photophobia | 52.33 | 46.76 | 17 | 1240 | 21252 | 90605938 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Dysphoria | 71.18 | 49.63 | 16 | 1181 | 6412 | 110581690 |
| Appetite disorder | 59.52 | 49.63 | 15 | 1182 | 9754 | 110578348 |
| Haemorrhagic diathesis | 53.13 | 49.63 | 13 | 1184 | 7495 | 110580607 |
| Thinking abnormal | 53.01 | 49.63 | 15 | 1182 | 15125 | 110572977 |
| Skin warm | 50.54 | 49.63 | 13 | 1184 | 9157 | 110578945 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D06BB11 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Antivirals |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000998 | Antiviral Agents |
| CHEBI has role | CHEBI:22587 | antiviral agents |
Related Drugs by ATC class:
D06BB Antivirals 11 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Herpes labialis | indication | 1475003 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Envelope glycoprotein | Membrane other | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4027425 | VUID |
| N0000179260 | NUI |
| D03884 | KEGG_DRUG |
| 285039 | RXNORM |
| 4027425 | VANDF |
| C0075770 | UMLSCUI |
| CHEBI:31000 | CHEBI |
| CHEMBL1200453 | ChEMBL_ID |
| DB00632 | DRUGBANK_ID |
| C529236 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12620 | PUBCHEM_CID |
| 9G1OE216XY | UNII |
| 15675 | MMSL |
| 313096 | MMSL |
| 37939 | MMSL |
| 009100 | NDDF |
| 411095000 | SNOMEDCT_US |
| 736813006 | SNOMEDCT_US |
| 9G1OE216XY | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| ABREVA | HUMAN OTC DRUG LABEL | 1 | 0135-0200 | CREAM | 100 mg | TOPICAL | NDA | 14 sections |
| ABREVA | HUMAN OTC DRUG LABEL | 1 | 0135-0300 | CREAM | 100 mg | TOPICAL | ANDA | 14 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 0363-6510 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 0363-8877 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Docosanol | HUMAN OTC DRUG LABEL | 1 | 0363-8980 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 0363-9220 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 0363-9222 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| DOCOSANOL | HUMAN OTC DRUG LABEL | 1 | 0536-1427 | CREAM | 100 mg | TOPICAL | ANDA | 10 sections |
| DOCOSANOL | HUMAN OTC DRUG LABEL | 1 | 0713-0353 | CREAM | 100 mg | TOPICAL | ANDA | 9 sections |
| Cold Sore Treatment Docosanol | HUMAN OTC DRUG LABEL | 1 | 10157-2124 | CREAM | 100 mg | TOPICAL | ANDA | 14 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 11673-769 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 11673-846 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Docosanol | HUMAN OTC DRUG LABEL | 1 | 11822-3450 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Docosanol | HUMAN OTC DRUG LABEL | 1 | 11822-3451 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 11822-3951 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 11822-3977 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 11822-4763 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 11822-6500 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Docosanol | HUMAN OTC DRUG LABEL | 1 | 21130-422 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 21130-605 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Docosanol | HUMAN OTC DRUG LABEL | 1 | 21130-770 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 21130-823 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Docosanol | HUMAN OTC DRUG LABEL | 1 | 21922-023 | CREAM | 100 mg | TOPICAL | ANDA | 12 sections |
| DOCOSANOL | Human OTC Drug Label | 1 | 30142-286 | CREAM | 100 mg | TOPICAL | ANDA | 12 sections |
| Cold Sore Fever Blister | HUMAN OTC DRUG LABEL | 1 | 30142-322 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 30142-869 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister Treatment | HUMAN OTC DRUG LABEL | 1 | 30142-981 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister | HUMAN OTC DRUG LABEL | 1 | 37808-223 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Treatment | HUMAN OTC DRUG LABEL | 1 | 37808-229 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |
| Cold Sore Fever Blister | HUMAN OTC DRUG LABEL | 1 | 37808-661 | CREAM | 100 mg | TOPICAL | ANDA | 13 sections |