All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

docosanol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	940	661-19-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: docosanol abreva behenic alcohol behenyl alcohol docosyl alcohol 1-Docosanol	Molecular weight: 326.61 Formula: C22H46O CLOGP: 10.35 LIPINSKI: 1 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -7.22 ROTB: 20 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	0 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70	57
kinase-selectivity-class	ACVRL1,AKT2,AXL,CAMK2A,CAMK2D,CDK4,CSNK2A2,EIF2AK3,EPHB4,FLT4,GRK2,INSR,LRRK2,MAP2K6,MAPK10,MAPK12,MAPK8,MELK,MTOR,NUAK1,PDK4,PDPK1,PLK1,PLK2,PLK3,PLK4,PRKCD,PTK2,SIK2,STK33,TEK,TTK,ZAP70	33
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
July 25, 2000	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dysphoria	73.20	46.76	17	1240	6137	90621053
Appetite disorder	66.53	46.76	17	1240	9116	90618074
Haemorrhagic diathesis	59.07	46.76	14	1243	5510	90621680
Thinking abnormal	57.68	46.76	16	1241	11716	90615474
Skin warm	54.47	46.76	14	1243	7673	90619517
Arthritis infective	53.93	46.76	14	1243	7978	90619212
Photophobia	52.33	46.76	17	1240	21252	90605938

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dysphoria	71.18	49.63	16	1181	6412	110581690
Appetite disorder	59.52	49.63	15	1182	9754	110578348
Haemorrhagic diathesis	53.13	49.63	13	1184	7495	110580607
Thinking abnormal	53.01	49.63	15	1182	15125	110572977
Skin warm	50.54	49.63	13	1184	9157	110578945

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D06BB11	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Antivirals
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000998	Antiviral Agents
CHEBI has role	CHEBI:22587	antiviral agents

Related Drugs by ATC class:

D06BB Antivirals 11 drugs

acyclovirberdazimeredoxudineibacitabineidoxuridineimiquimodinosinepenciclovirpodophyllotoxinsinecatechinstromantadine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Herpes labialis	indication	1475003

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Envelope glycoprotein	Membrane other		GN_HHV11 GM_HHV11 GE_HHV11 GH_HHV11 GJ_HHV11 GG_HHV11 GI_HHV11 GL_HHV11 GB_HHV11 GC_HHV11 GK_HHV11 GD_HHV11	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4027425	VUID
N0000179260	NUI
D03884	KEGG_DRUG
285039	RXNORM
4027425	VANDF
C0075770	UMLSCUI
CHEBI:31000	CHEBI
CHEMBL1200453	ChEMBL_ID
DB00632	DRUGBANK_ID
C529236	MESH_SUPPLEMENTAL_RECORD_UI
12620	PUBCHEM_CID
9G1OE216XY	UNII
15675	MMSL
313096	MMSL
37939	MMSL
009100	NDDF
411095000	SNOMEDCT_US
736813006	SNOMEDCT_US
9G1OE216XY	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
ABREVA	HUMAN OTC DRUG LABEL	1	0135-0200	CREAM	100 mg	TOPICAL	NDA	14 sections
ABREVA	HUMAN OTC DRUG LABEL	1	0135-0300	CREAM	100 mg	TOPICAL	ANDA	14 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	0363-6510	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	0363-8877	CREAM	100 mg	TOPICAL	ANDA	13 sections
Docosanol	HUMAN OTC DRUG LABEL	1	0363-8980	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	0363-9220	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	0363-9222	CREAM	100 mg	TOPICAL	ANDA	13 sections
DOCOSANOL	HUMAN OTC DRUG LABEL	1	0536-1427	CREAM	100 mg	TOPICAL	ANDA	10 sections
DOCOSANOL	HUMAN OTC DRUG LABEL	1	0713-0353	CREAM	100 mg	TOPICAL	ANDA	9 sections
Cold Sore Treatment Docosanol	HUMAN OTC DRUG LABEL	1	10157-2124	CREAM	100 mg	TOPICAL	ANDA	14 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	11673-769	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	11673-846	CREAM	100 mg	TOPICAL	ANDA	13 sections
Docosanol	HUMAN OTC DRUG LABEL	1	11822-3450	CREAM	100 mg	TOPICAL	ANDA	13 sections
Docosanol	HUMAN OTC DRUG LABEL	1	11822-3451	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	11822-3951	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	11822-3977	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	11822-4763	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	11822-6500	CREAM	100 mg	TOPICAL	ANDA	13 sections
Docosanol	HUMAN OTC DRUG LABEL	1	21130-422	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	21130-605	CREAM	100 mg	TOPICAL	ANDA	13 sections
Docosanol	HUMAN OTC DRUG LABEL	1	21130-770	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	21130-823	CREAM	100 mg	TOPICAL	ANDA	13 sections
Docosanol	HUMAN OTC DRUG LABEL	1	21922-023	CREAM	100 mg	TOPICAL	ANDA	12 sections
DOCOSANOL	Human OTC Drug Label	1	30142-286	CREAM	100 mg	TOPICAL	ANDA	12 sections
Cold Sore Fever Blister	HUMAN OTC DRUG LABEL	1	30142-322	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	30142-869	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister Treatment	HUMAN OTC DRUG LABEL	1	30142-981	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister	HUMAN OTC DRUG LABEL	1	37808-223	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Treatment	HUMAN OTC DRUG LABEL	1	37808-229	CREAM	100 mg	TOPICAL	ANDA	13 sections
Cold Sore Fever Blister	HUMAN OTC DRUG LABEL	1	37808-661	CREAM	100 mg	TOPICAL	ANDA	13 sections