podophyllotoxin

Your question

Ask in your own words. Each question is answered independently.

Explore sample questions

Select a question to fill the editor, then ask it or make it your own.

DrugCentral answer

Your answer will appear here. Open linked drug cards in a new tab to explore the source details.

About Ask DrugCentral

Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.

General architecture

Ask a questionThe browser sends your question to the same-origin Django chat API.
Retrieve and generateThe API forwards the question to the configured DrugCentral retrieval-augmented generation (RAG) service, which returns an AI-generated answer.
Explore the answerThe app resolves cited drug-card names and displays the answer with links to drug records.

Using the assistant

Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.

Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.

Stem definition	Drug id	CAS RN
	3481	518-28-5

Stem definition

Drug id

CAS RN

3481

518-28-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: podophyllotoxin podofilox condyline	A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. Molecular weight: 414.41 Formula: C22H22O8 CLOGP: 2.12 LIPINSKI: 0 HAC: 8 HDO: 1 TPSA: 92.68 ALOGS: -3.56 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

podophyllotoxin
podofilox
condyline

A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.

Molecular weight: 414.41
Formula: C22H22O8
CLOGP: 2.12
LIPINSKI: 0
HAC: 8
HDO: 1
TPSA: 92.68
ALOGS: -3.56
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value
kinase-safety-class	ACVR2B,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TTK,ZAP70	45
kinase-selectivity-class	ACVR2B,AXL,EPHB4,GRK2,PDK4	5
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Property

Description

Value

Unit

Confidence

Similarity

kinase-safety-class

ACVR2B,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TTK,ZAP70

kinase-selectivity-class

ACVR2B,AXL,EPHB4,GRK2,PDK4

pfas-class

PFAS structural alert (1 = True, 0 = False)

Date	Agency	Company	Orphan
Dec. 13, 1990	FDA	ACTAVIS LABS UT INC

Date

Agency

Company

Orphan

Dec. 13, 1990

FDA

ACTAVIS LABS UT INC

Pharmacologic Action:

Source	Code	Description
ATC	D06BB04	DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Antivirals
FDA PE	N0000008732	Decreased Mitosis
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D000972	Antineoplastic Agents, Phytogenic
MeSH PA	D003879	Dermatologic Agents
MeSH PA	D007641	Keratolytic Agents
MeSH PA	D050256	Antimitotic Agents
MeSH PA	D050257	Tubulin Modulators
CHEBI has role	CHEBI:22587	antiviral agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:50176	keratolytic drug
CHEBI has role	CHEBI:60832	tubulin modulator
CHEBI has role	CHEBI:61951	microtubule-destabilising agent
CHEBI has role	CHEBI:64911	antimitotic
CHEBI has role	CHEBI:76924	plant metabolite

Source

Code

Description

ATC

D06BB04

DERMATOLOGICALS
ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
CHEMOTHERAPEUTICS FOR TOPICAL USE
Antivirals

FDA PE

N0000008732

Decreased Mitosis

MeSH PA

D000970

Antineoplastic Agents

MeSH PA

D000972

Antineoplastic Agents, Phytogenic

MeSH PA

D003879

Dermatologic Agents

MeSH PA

D007641

Keratolytic Agents

MeSH PA

D050256

Antimitotic Agents

MeSH PA

D050257

Tubulin Modulators

CHEBI has role

CHEBI:22587

antiviral agent

CHEBI has role

CHEBI:35610

antineoplastic agent

CHEBI has role

CHEBI:50176

keratolytic drug

CHEBI has role

CHEBI:60832

tubulin modulator

CHEBI has role

CHEBI:61951

microtubule-destabilising agent

CHEBI has role

CHEBI:64911

antimitotic

CHEBI has role

CHEBI:76924

plant metabolite

Disease	Relation	SNOMED_ID	DOID
Condyloma acuminatum	indication	240542006	DOID:11168
Pregnancy, function	contraindication	289908002

Disease

Relation

SNOMED_ID

DOID

Condyloma acuminatum

indication

240542006

DOID:11168

Pregnancy, function

contraindication

289908002

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.37	acidic

Dissociation level

Dissociation constant

Type (acidic/basic)

pKa1

10.37

acidic

Bioactivity Summary:

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN	IC50	6.22	DRUG MATRIX
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	IC50	7.85	CHEMBL
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN	IC50	5.40	DRUG MATRIX
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN	IC50	5.30	DRUG MATRIX
Tubulin	Structural	P04350 P07437 P68363 P68366 P68371 Q13509 Q13748 Q13885 Q3ZCM7 Q6PEY2 Q71U36 Q9BQE3 Q9BUF5 Q9BVA1 Q9H4B7	TBB4A_HUMAN TBB5_HUMAN TBA1B_HUMAN TBA4A_HUMAN TBB4B_HUMAN TBB3_HUMAN TBA3C_HUMAN TBB2A_HUMAN TBB8_HUMAN TBA3E_HUMAN TBA1A_HUMAN TBA1C_HUMAN TBB6_HUMAN TBB2B_HUMAN TBB1_HUMAN	IC50	6	CHEMBL
Regulatory protein E2	Transcription factor		VE2_HPV11	Kd	4.70	CHEMBL
Tubulin alpha-1A chain	Structural		TBA1A_PIG	IC50	6.34	CHEMBL
Regulatory protein E2	Transcription factor		VE2_HPV1A	Kd	5.98	CHEMBL
Tubulin	Structural		TBB2B_BOVIN Q862F3_BOVIN Q862L2_BOVIN	IC50	6.34	CHEMBL
Tubulin	Structural		TBA1A_PIG TBB_PIG	Ki	5.66	CHEMBL
Human papillomavirus regulatory protein E2	Transcription factor		VE2_HPV16	Kd	4.15	CHEMBL

Target

Class

Pharos

UniProt

Action

Type

Activity value
(-log[M])

Mechanism
action

Bioact source

MoA source

Cytochrome P450 3A4

Enzyme

P08684

CP3A4_HUMAN

IC50

6.22

DRUG MATRIX

Glucocorticoid receptor

Nuclear hormone receptor

P04150

GCR_HUMAN

IC50

7.85

CHEMBL

Cytochrome P450 2C9

Enzyme

P11712

CP2C9_HUMAN

IC50

5.40

DRUG MATRIX

Cytochrome P450 2C19

Enzyme

P33261

CP2CJ_HUMAN

IC50

5.30

DRUG MATRIX

Tubulin

Structural

IC50

CHEMBL

Regulatory protein E2

Transcription factor

VE2_HPV11

4.70

CHEMBL

Tubulin alpha-1A chain

Structural

TBA1A_PIG

IC50

6.34

CHEMBL

Regulatory protein E2

Transcription factor

VE2_HPV1A

5.98

CHEMBL

Tubulin

Structural

TBB2B_BOVIN

Q862F3_BOVIN

Q862L2_BOVIN

IC50

6.34

CHEMBL

Tubulin

Structural

TBA1A_PIG

TBB_PIG

5.66

CHEMBL

Human papillomavirus regulatory protein E2

Transcription factor

VE2_HPV16

4.15

CHEMBL

External reference:

ID	Source
4019583	VUID
N0000147681	NUI
D05529	KEGG_DRUG
4019583	VANDF
C0032334	UMLSCUI
CHEBI:50305	CHEBI
POD	PDB_CHEM_ID
CHEMBL61	ChEMBL_ID
D011034	MESH_DESCRIPTOR_UI
DB01179	DRUGBANK_ID
10607	PUBCHEM_CID
225782	RXNORM
5312	MMSL
003584	NDDF
415128000	SNOMEDCT_US
76575003	SNOMEDCT_US
13598	IUPHAR_LIGAND_ID
L36H50F353	UNII

Source

4019583

VUID

N0000147681

NUI

D05529

KEGG_DRUG

4019583

VANDF

C0032334

UMLSCUI

CHEBI

PDB_CHEM_ID

ChEMBL_ID

MESH_DESCRIPTOR_UI

DRUGBANK_ID

PUBCHEM_CID

RXNORM

5312

MMSL

003584

NDDF

SNOMEDCT_US

SNOMEDCT_US

IUPHAR_LIGAND_ID

UNII

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Condylox	HUMAN PRESCRIPTION DRUG LABEL	1	0023-6118	GEL	5 mg	TOPICAL	NDA	23 sections
PODOFILOX	HUMAN PRESCRIPTION DRUG LABEL	1	0574-0611	SOLUTION	5 mg	TOPICAL	ANDA	23 sections
Podofilox	HUMAN PRESCRIPTION DRUG LABEL	1	0574-0621	GEL	5 mg	TOPICAL	ANDA	20 sections
Podofilox	HUMAN PRESCRIPTION DRUG LABEL	1	54868-6198	SOLUTION	5 mg	TOPICAL	NDA authorized generic	20 sections

Product

Ask DrugCentral

Your question

DrugCentral answer

About Ask DrugCentral

General architecture

Using the assistant

podophyllotoxin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: