fomivirsen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antisense oligonucleotides 4751 160369-77-7

Description:

MoleculeDescription

Synonyms:

  • fomivirsen sodium
  • fomivirsen
Fomivirsen is a phosphorothioate oligonucleotide that inhibits human cytomegalovirus (HCMV) replication through an antisense mechanism. The nucleotide sequence of fomivirsen is complementary to a sequence in mRNA transcripts of the major immediate early region 2 (IE2) of HCMV. This region of mRNA encodes several proteins responsible for regulation of viral gene expression that are essential for production of infectious CMV. Binding of fomivirsen to the target mRNA results in inhibition of IE2 protein synthesis, subsequently inhibiting virus replication.
  • Molecular weight:
  • Formula:
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Aug. 26, 1998 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC S01AD08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Antivirals
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
MeSH PA D015335 Molecular Probes
MeSH PA D016376 Oligonucleotides, Antisense
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:66981 ophthalmology drug

Related Drugs by ATC class:

S01AD Antivirals 6 drugs
acyclovirfamciclovirgancicloviridoxuridinetrifluridinevidarabine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Cytomegaloviral retinitis indication 22455005




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Immediate early protein IE1 mRNA RNA ANTISENSE INHIBITOR UNKNOWN DRUG LABEL

External reference:

IDSource
D02736 KEGG_DRUG
4021137 VUID
N0000148591 NUI
144245-52-3 SECONDARY_CAS_RN
4021137 VANDF
4024128 VANDF
CHEBI:749580 CHEBI
CHEMBL1201688 ChEMBL_ID
CHEMBL1201512 ChEMBL_ID
C091346 MESH_SUPPLEMENTAL_RECORD_UI
13533 IUPHAR_LIGAND_ID
DB06759 DRUGBANK_ID
QX5LK7YCHV UNII
314633 RXNORM
7946 MMSL
007678 NDDF
007679 NDDF
108868005 SNOMEDCT_US
108869002 SNOMEDCT_US
373730007 SNOMEDCT_US
C0292819 UMLSCUI
7509 INN_ID

Pharmaceutical products:

None