Stem definition | Drug id | CAS RN |
---|---|---|
antivirals bicyclic heterocycle compounds | 2801 | 175865-59-5 |
Dose | Unit | Route |
---|---|---|
0.90 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 70 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 84.66 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 61 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
March 29, 2001 | FDA | HOFFMANN LA ROCHE | |
Nov. 5, 2004 | PMDA | Tanabe Seiyaku Co., Ltd. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cytomegalovirus infection | 829.37 | 18.72 | 276 | 14297 | 17686 | 50572865 |
Leukopenia | 435.63 | 18.72 | 260 | 14313 | 67268 | 50523283 |
Cytomegalovirus viraemia | 428.79 | 18.72 | 122 | 14451 | 4587 | 50585964 |
Transplant rejection | 366.09 | 18.72 | 128 | 14445 | 9481 | 50581070 |
Pathogen resistance | 342.19 | 18.72 | 107 | 14466 | 5582 | 50584969 |
Drug resistance | 316.82 | 18.72 | 139 | 14434 | 18850 | 50571701 |
Neutropenia | 259.97 | 18.72 | 263 | 14310 | 147702 | 50442849 |
BK virus infection | 206.42 | 18.72 | 62 | 14511 | 2819 | 50587732 |
Kidney transplant rejection | 194.61 | 18.72 | 64 | 14509 | 3923 | 50586628 |
Polyomavirus-associated nephropathy | 172.33 | 18.72 | 47 | 14526 | 1505 | 50589046 |
Pancytopenia | 144.74 | 18.72 | 148 | 14425 | 83882 | 50506669 |
Immunosuppressant drug level increased | 144.51 | 18.72 | 48 | 14525 | 3034 | 50587517 |
Off label use | 142.24 | 18.72 | 375 | 14198 | 474051 | 50116500 |
Agranulocytosis | 123.71 | 18.72 | 77 | 14496 | 21344 | 50569207 |
Epstein-Barr virus infection | 122.40 | 18.72 | 53 | 14520 | 6944 | 50583607 |
Smooth muscle cell neoplasm | 122.36 | 18.72 | 31 | 14542 | 740 | 50589811 |
Transplant dysfunction | 121.31 | 18.72 | 47 | 14526 | 4637 | 50585914 |
Encephalitis cytomegalovirus | 117.49 | 18.72 | 28 | 14545 | 514 | 50590037 |
Cytomegalovirus gastrointestinal infection | 117.30 | 18.72 | 25 | 14548 | 269 | 50590282 |
Post transplant lymphoproliferative disorder | 111.78 | 18.72 | 43 | 14530 | 4161 | 50586390 |
Delayed graft function | 107.15 | 18.72 | 29 | 14544 | 901 | 50589650 |
Cytomegalovirus colitis | 102.41 | 18.72 | 33 | 14540 | 1894 | 50588657 |
Lung transplant rejection | 98.15 | 18.72 | 26 | 14547 | 743 | 50589808 |
Posterior reversible encephalopathy syndrome | 94.72 | 18.72 | 57 | 14516 | 14871 | 50575680 |
Nocardiosis | 94.02 | 18.72 | 30 | 14543 | 1668 | 50588883 |
Lymphocele | 92.67 | 18.72 | 25 | 14548 | 767 | 50589784 |
Cytomegalovirus infection reactivation | 92.34 | 18.72 | 33 | 14540 | 2598 | 50587953 |
Complications of transplanted kidney | 90.64 | 18.72 | 31 | 14542 | 2142 | 50588409 |
Bronchopulmonary aspergillosis | 84.37 | 18.72 | 42 | 14531 | 7550 | 50583001 |
Renal transplant failure | 84.35 | 18.72 | 22 | 14551 | 591 | 50589960 |
Thrombotic microangiopathy | 84.23 | 18.72 | 44 | 14529 | 8747 | 50581804 |
Intentional product use issue | 83.92 | 18.72 | 107 | 14466 | 76811 | 50513740 |
Graft versus host disease | 83.31 | 18.72 | 39 | 14534 | 6127 | 50584424 |
Ureaplasma infection | 83.06 | 18.72 | 21 | 14552 | 497 | 50590054 |
Cytomegalovirus chorioretinitis | 80.87 | 18.72 | 26 | 14547 | 1481 | 50589070 |
Acute kidney injury | 80.20 | 18.72 | 192 | 14381 | 227866 | 50362685 |
Blood creatinine increased | 80.03 | 18.72 | 104 | 14469 | 76056 | 50514495 |
Renal tubular necrosis | 78.22 | 18.72 | 44 | 14529 | 10124 | 50580427 |
Strongyloidiasis | 77.00 | 18.72 | 22 | 14551 | 837 | 50589714 |
Fatigue | 76.20 | 18.72 | 56 | 14517 | 707545 | 49883006 |
Hyperammonaemia | 73.62 | 18.72 | 33 | 14540 | 4691 | 50585860 |
Nephropathy toxic | 73.55 | 18.72 | 39 | 14534 | 7990 | 50582561 |
Arthralgia | 71.74 | 18.72 | 19 | 14554 | 438683 | 50151868 |
Human ehrlichiosis | 71.11 | 18.72 | 15 | 14558 | 153 | 50590398 |
Pneumonia cytomegaloviral | 70.59 | 18.72 | 25 | 14548 | 1916 | 50588635 |
Renal impairment | 62.48 | 18.72 | 92 | 14481 | 75569 | 50514982 |
Scedosporium infection | 61.84 | 18.72 | 16 | 14557 | 416 | 50590135 |
Enterococcal infection | 58.96 | 18.72 | 32 | 14541 | 6866 | 50583685 |
Transplant failure | 58.04 | 18.72 | 20 | 14553 | 1413 | 50589138 |
Thrombocytopenia | 57.77 | 18.72 | 119 | 14454 | 127554 | 50462997 |
Myelosuppression | 57.13 | 18.72 | 40 | 14533 | 13477 | 50577074 |
Aspergillus infection | 56.52 | 18.72 | 31 | 14542 | 6790 | 50583761 |
Pneumocystis jirovecii pneumonia | 56.47 | 18.72 | 41 | 14532 | 14622 | 50575929 |
Neutrophil Pelger-Huet anomaly present | 55.35 | 18.72 | 11 | 14562 | 81 | 50590470 |
Escherichia infection | 54.88 | 18.72 | 36 | 14537 | 10905 | 50579646 |
Adenoviral hepatitis | 54.73 | 18.72 | 13 | 14560 | 235 | 50590316 |
Adenovirus infection | 52.16 | 18.72 | 23 | 14550 | 3145 | 50587406 |
Viraemia | 51.42 | 18.72 | 17 | 14556 | 1058 | 50589493 |
Fall | 50.16 | 18.72 | 17 | 14556 | 334915 | 50255636 |
Pain | 50.04 | 18.72 | 56 | 14517 | 578847 | 50011704 |
Epstein-Barr virus infection reactivation | 49.37 | 18.72 | 14 | 14559 | 518 | 50590033 |
Renal transplant | 49.32 | 18.72 | 17 | 14556 | 1202 | 50589349 |
Liver transplant rejection | 48.12 | 18.72 | 17 | 14556 | 1293 | 50589258 |
Pseudomonas infection | 47.23 | 18.72 | 31 | 14542 | 9399 | 50581152 |
Graft loss | 45.23 | 18.72 | 12 | 14561 | 345 | 50590206 |
Systemic candida | 45.11 | 18.72 | 20 | 14553 | 2770 | 50587781 |
Peripheral swelling | 44.62 | 18.72 | 4 | 14569 | 205932 | 50384619 |
Mucormycosis | 44.04 | 18.72 | 19 | 14554 | 2464 | 50588087 |
Adrenal mass | 43.87 | 18.72 | 14 | 14559 | 778 | 50589773 |
Toxoplasmosis | 43.12 | 18.72 | 16 | 14557 | 1401 | 50589150 |
Hepatocellular injury | 41.53 | 18.72 | 44 | 14529 | 25903 | 50564648 |
Pericarditis constrictive | 40.54 | 18.72 | 11 | 14562 | 345 | 50590206 |
Cytomegalovirus test positive | 40.05 | 18.72 | 18 | 14555 | 2574 | 50587977 |
Product use in unapproved indication | 40.05 | 18.72 | 97 | 14476 | 115722 | 50474829 |
Joint swelling | 39.30 | 18.72 | 11 | 14562 | 245275 | 50345276 |
Cholestasis | 38.76 | 18.72 | 42 | 14531 | 25359 | 50565192 |
Pyrexia | 38.61 | 18.72 | 213 | 14360 | 379990 | 50210561 |
Pyelonephritis | 38.47 | 18.72 | 33 | 14540 | 14956 | 50575595 |
Swelling | 38.34 | 18.72 | 6 | 14567 | 200866 | 50389685 |
Hypersensitivity | 37.69 | 18.72 | 8 | 14565 | 215153 | 50375398 |
Bone marrow failure | 37.56 | 18.72 | 43 | 14530 | 27581 | 50562970 |
Cytopenia | 37.15 | 18.72 | 26 | 14547 | 8749 | 50581802 |
Klebsiella infection | 36.88 | 18.72 | 24 | 14549 | 7170 | 50583381 |
Alopecia | 35.69 | 18.72 | 13 | 14560 | 245034 | 50345517 |
Urosepsis | 35.59 | 18.72 | 32 | 14541 | 15433 | 50575118 |
Pleural mesothelioma malignant | 35.53 | 18.72 | 7 | 14566 | 49 | 50590502 |
Anaemia | 35.28 | 18.72 | 155 | 14418 | 252301 | 50338250 |
Dizziness | 35.09 | 18.72 | 29 | 14544 | 346340 | 50244211 |
Drug level increased | 35.04 | 18.72 | 35 | 14538 | 19233 | 50571318 |
Infusion related reaction | 34.89 | 18.72 | 4 | 14569 | 169553 | 50420998 |
Abdominal discomfort | 34.23 | 18.72 | 12 | 14561 | 231629 | 50358922 |
Renal artery stenosis | 33.67 | 18.72 | 14 | 14559 | 1658 | 50588893 |
Sepsis | 33.48 | 18.72 | 99 | 14474 | 132826 | 50457725 |
Escherichia urinary tract infection | 33.22 | 18.72 | 26 | 14547 | 10369 | 50580182 |
Parvovirus B19 infection | 32.81 | 18.72 | 10 | 14563 | 477 | 50590074 |
Weight increased | 32.43 | 18.72 | 9 | 14564 | 201882 | 50388669 |
Acinetobacter infection | 32.32 | 18.72 | 13 | 14560 | 1414 | 50589137 |
Drug hypersensitivity | 32.27 | 18.72 | 16 | 14557 | 250994 | 50339557 |
Superinfection bacterial | 32.26 | 18.72 | 10 | 14563 | 505 | 50590046 |
Parainfluenzae virus infection | 32.12 | 18.72 | 14 | 14559 | 1861 | 50588690 |
Aplasia pure red cell | 31.76 | 18.72 | 18 | 14555 | 4197 | 50586354 |
Septic shock | 31.56 | 18.72 | 58 | 14515 | 57117 | 50533434 |
Cystitis haemorrhagic | 31.15 | 18.72 | 17 | 14556 | 3685 | 50586866 |
Cytomegalovirus oesophagitis | 31.11 | 18.72 | 8 | 14565 | 203 | 50590348 |
Venous haemorrhage | 30.96 | 18.72 | 8 | 14565 | 207 | 50590344 |
Cryptococcosis | 30.64 | 18.72 | 11 | 14562 | 877 | 50589674 |
Tonic clonic movements | 30.57 | 18.72 | 12 | 14561 | 1225 | 50589326 |
Dyspnoea | 30.30 | 18.72 | 71 | 14502 | 547537 | 50043014 |
Epstein-Barr virus associated lymphoproliferative disorder | 30.21 | 18.72 | 13 | 14560 | 1676 | 50588875 |
Product dose omission issue | 29.89 | 18.72 | 8 | 14565 | 183830 | 50406721 |
Urate nephropathy | 29.82 | 18.72 | 7 | 14566 | 120 | 50590431 |
Mesothelioma malignant | 29.75 | 18.72 | 6 | 14567 | 48 | 50590503 |
Lymphopenia | 29.56 | 18.72 | 29 | 14544 | 15592 | 50574959 |
JC virus infection | 29.31 | 18.72 | 13 | 14560 | 1802 | 50588749 |
Oesophageal candidiasis | 28.93 | 18.72 | 18 | 14555 | 4976 | 50585575 |
Eye infection toxoplasmal | 28.86 | 18.72 | 8 | 14565 | 272 | 50590279 |
Pneumonia fungal | 28.71 | 18.72 | 17 | 14556 | 4303 | 50586248 |
Herpes simplex viraemia | 28.57 | 18.72 | 7 | 14566 | 145 | 50590406 |
Septal panniculitis | 28.55 | 18.72 | 6 | 14567 | 60 | 50590491 |
Reticulocytopenia | 28.46 | 18.72 | 6 | 14567 | 61 | 50590490 |
Complications of transplant surgery | 27.96 | 18.72 | 7 | 14566 | 159 | 50590392 |
Urinary tract infection | 27.90 | 18.72 | 133 | 14440 | 223887 | 50366664 |
Oral candidiasis | 27.63 | 18.72 | 29 | 14544 | 16886 | 50573665 |
Hyperuricaemia | 27.45 | 18.72 | 17 | 14556 | 4663 | 50585888 |
Pain in extremity | 27.43 | 18.72 | 23 | 14550 | 272842 | 50317709 |
Superinfection viral | 27.34 | 18.72 | 5 | 14568 | 22 | 50590529 |
Pancreatic pseudoaneurysm | 27.11 | 18.72 | 6 | 14567 | 78 | 50590473 |
Cytomegalovirus gastritis | 27.09 | 18.72 | 7 | 14566 | 181 | 50590370 |
Epstein-Barr viraemia | 27.05 | 18.72 | 10 | 14563 | 866 | 50589685 |
Urinary tract infection bacterial | 26.68 | 18.72 | 16 | 14557 | 4143 | 50586408 |
Venoocclusive liver disease | 26.32 | 18.72 | 16 | 14557 | 4245 | 50586306 |
Brain abscess | 26.28 | 18.72 | 12 | 14561 | 1779 | 50588772 |
Central nervous system fungal infection | 26.19 | 18.72 | 6 | 14567 | 92 | 50590459 |
Cervicitis | 26.18 | 18.72 | 8 | 14565 | 385 | 50590166 |
Escherichia sepsis | 26.11 | 18.72 | 16 | 14557 | 4308 | 50586243 |
Infection reactivation | 25.89 | 18.72 | 10 | 14563 | 977 | 50589574 |
Ascites | 25.89 | 18.72 | 41 | 14532 | 35820 | 50554731 |
Pulmonary mucormycosis | 25.81 | 18.72 | 7 | 14566 | 219 | 50590332 |
Febrile neutropenia | 25.78 | 18.72 | 74 | 14499 | 97593 | 50492958 |
Feeling abnormal | 25.71 | 18.72 | 3 | 14570 | 125489 | 50465062 |
Hepatic necrosis | 25.66 | 18.72 | 17 | 14556 | 5231 | 50585320 |
Microsporidia infection | 25.28 | 18.72 | 7 | 14566 | 237 | 50590314 |
Multiple organ dysfunction syndrome | 25.22 | 18.72 | 49 | 14524 | 50288 | 50540263 |
Heart transplant rejection | 25.05 | 18.72 | 8 | 14565 | 446 | 50590105 |
Diabetes mellitus | 24.89 | 18.72 | 48 | 14525 | 48985 | 50541566 |
Polyomavirus viraemia | 24.84 | 18.72 | 8 | 14565 | 458 | 50590093 |
Human herpesvirus 6 infection reactivation | 24.64 | 18.72 | 6 | 14567 | 121 | 50590430 |
Herpes simplex oesophagitis | 24.50 | 18.72 | 6 | 14567 | 124 | 50590427 |
Drug interaction | 24.47 | 18.72 | 118 | 14455 | 199503 | 50391048 |
Graft versus host disease in gastrointestinal tract | 24.04 | 18.72 | 13 | 14560 | 2768 | 50587783 |
Proteus infection | 23.72 | 18.72 | 9 | 14564 | 838 | 50589713 |
Coronavirus infection | 23.41 | 18.72 | 13 | 14560 | 2916 | 50587635 |
Muscle spasms | 23.39 | 18.72 | 4 | 14569 | 125549 | 50465002 |
Bacterial infection | 23.24 | 18.72 | 26 | 14547 | 16255 | 50574296 |
Respiratory tract infection viral | 23.08 | 18.72 | 11 | 14562 | 1798 | 50588753 |
Insomnia | 22.68 | 18.72 | 11 | 14562 | 174854 | 50415697 |
Renal lymphocele | 22.59 | 18.72 | 5 | 14568 | 65 | 50590486 |
Rash | 22.38 | 18.72 | 59 | 14514 | 437412 | 50153139 |
Acute graft versus host disease | 22.26 | 18.72 | 14 | 14559 | 3944 | 50586607 |
Anorexia nervosa | 22.18 | 18.72 | 6 | 14567 | 186 | 50590365 |
Pneumonia influenzal | 22.07 | 18.72 | 10 | 14563 | 1457 | 50589094 |
Disseminated cryptococcosis | 22.04 | 18.72 | 7 | 14566 | 383 | 50590168 |
Back pain | 21.55 | 18.72 | 19 | 14554 | 220011 | 50370540 |
Haematotoxicity | 21.52 | 18.72 | 18 | 14555 | 7877 | 50582674 |
Glomerulonephritis | 21.49 | 18.72 | 10 | 14563 | 1549 | 50589002 |
Hypertensive emergency | 21.46 | 18.72 | 10 | 14563 | 1553 | 50588998 |
Liver transplant | 21.36 | 18.72 | 11 | 14562 | 2121 | 50588430 |
Genital lesion | 21.34 | 18.72 | 6 | 14567 | 215 | 50590336 |
Systemic lupus erythematosus | 21.25 | 18.72 | 7 | 14566 | 140615 | 50449936 |
Complications of transplanted lung | 21.24 | 18.72 | 6 | 14567 | 219 | 50590332 |
Cytomegalovirus enteritis | 21.16 | 18.72 | 6 | 14567 | 222 | 50590329 |
Respiratory failure | 21.14 | 18.72 | 66 | 14507 | 91115 | 50499436 |
Rhinovirus infection | 21.14 | 18.72 | 13 | 14560 | 3521 | 50587030 |
Human herpesvirus 8 infection | 21.08 | 18.72 | 6 | 14567 | 225 | 50590326 |
Viral mutation identified | 21.07 | 18.72 | 10 | 14563 | 1619 | 50588932 |
Delayed engraftment | 20.77 | 18.72 | 5 | 14568 | 96 | 50590455 |
Asterixis | 20.75 | 18.72 | 9 | 14564 | 1182 | 50589369 |
Malaise | 20.58 | 18.72 | 41 | 14532 | 335491 | 50255060 |
Hepatic cyst infection | 20.48 | 18.72 | 5 | 14568 | 102 | 50590449 |
Urticaria | 20.38 | 18.72 | 6 | 14567 | 129555 | 50460996 |
Escherichia bacteraemia | 20.02 | 18.72 | 12 | 14561 | 3104 | 50587447 |
Mycobacterium abscessus infection | 19.92 | 18.72 | 7 | 14566 | 524 | 50590027 |
Nephrogenic diabetes insipidus | 19.86 | 18.72 | 8 | 14565 | 873 | 50589678 |
Obliterative bronchiolitis | 19.84 | 18.72 | 10 | 14563 | 1843 | 50588708 |
Periostitis | 19.75 | 18.72 | 6 | 14567 | 283 | 50590268 |
No adverse event | 19.71 | 18.72 | 35 | 14538 | 33543 | 50557008 |
Serum sickness | 19.58 | 18.72 | 11 | 14562 | 2521 | 50588030 |
Pulmonary alveolar haemorrhage | 19.58 | 18.72 | 13 | 14560 | 4014 | 50586537 |
Donor specific antibody present | 19.40 | 18.72 | 5 | 14568 | 128 | 50590423 |
Haemothorax | 19.28 | 18.72 | 10 | 14563 | 1956 | 50588595 |
Cytomegalovirus hepatitis | 19.21 | 18.72 | 6 | 14567 | 311 | 50590240 |
Drug ineffective | 19.19 | 18.72 | 148 | 14425 | 819185 | 49771366 |
Oropharyngeal candidiasis | 19.14 | 18.72 | 8 | 14565 | 960 | 50589591 |
Drug intolerance | 19.05 | 18.72 | 21 | 14552 | 219083 | 50371468 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cytomegalovirus infection | 745.89 | 15.66 | 356 | 21341 | 22859 | 29529971 |
Cytomegalovirus viraemia | 619.39 | 15.66 | 216 | 21481 | 6104 | 29546726 |
Leukopenia | 434.58 | 15.66 | 344 | 21353 | 54859 | 29497971 |
Transplant rejection | 428.14 | 15.66 | 183 | 21514 | 9029 | 29543801 |
Drug resistance | 339.59 | 15.66 | 206 | 21491 | 21334 | 29531496 |
Pathogen resistance | 237.67 | 15.66 | 117 | 21580 | 7999 | 29544831 |
Polyomavirus-associated nephropathy | 224.77 | 15.66 | 87 | 21610 | 3309 | 29549521 |
Neutropenia | 192.13 | 15.66 | 345 | 21352 | 131366 | 29421464 |
Kidney transplant rejection | 190.37 | 15.66 | 96 | 21601 | 6909 | 29545921 |
Cytomegalovirus colitis | 180.44 | 15.66 | 68 | 21629 | 2401 | 29550429 |
BK virus infection | 156.36 | 15.66 | 74 | 21623 | 4633 | 29548197 |
Cytomegalovirus chorioretinitis | 155.88 | 15.66 | 66 | 21631 | 3172 | 29549658 |
Pneumonia cytomegaloviral | 140.29 | 15.66 | 58 | 21639 | 2624 | 29550206 |
Delayed graft function | 136.93 | 15.66 | 52 | 21645 | 1875 | 29550955 |
Transplant dysfunction | 135.59 | 15.66 | 54 | 21643 | 2216 | 29550614 |
Pancytopenia | 134.22 | 15.66 | 228 | 21469 | 82940 | 29469890 |
Post transplant lymphoproliferative disorder | 128.28 | 15.66 | 68 | 21629 | 5425 | 29547405 |
Complications of transplanted kidney | 127.78 | 15.66 | 61 | 21636 | 3893 | 29548937 |
Off label use | 117.63 | 15.66 | 483 | 21214 | 300317 | 29252513 |
Immunosuppressant drug level increased | 114.14 | 15.66 | 60 | 21637 | 4705 | 29548125 |
Cytomegalovirus syndrome | 111.30 | 15.66 | 24 | 21673 | 93 | 29552737 |
Cytomegalovirus infection reactivation | 109.01 | 15.66 | 52 | 21645 | 3312 | 29549518 |
Epstein-Barr virus infection | 108.47 | 15.66 | 65 | 21632 | 6564 | 29546266 |
Nocardiosis | 107.50 | 15.66 | 51 | 21646 | 3209 | 29549621 |
Aspergillus infection | 102.98 | 15.66 | 75 | 21622 | 10506 | 29542324 |
Immune reconstitution inflammatory syndrome | 96.31 | 15.66 | 64 | 21633 | 7738 | 29545092 |
Mucormycosis | 96.05 | 15.66 | 55 | 21642 | 5103 | 29547727 |
Agranulocytosis | 95.92 | 15.66 | 95 | 21602 | 20245 | 29532585 |
Intentional product use issue | 87.02 | 15.66 | 130 | 21567 | 42368 | 29510462 |
Renal impairment | 84.37 | 15.66 | 185 | 21512 | 81148 | 29471682 |
Cytomegalovirus test positive | 81.69 | 15.66 | 43 | 21654 | 3380 | 29549450 |
Cytomegalovirus enteritis | 79.96 | 15.66 | 24 | 21673 | 412 | 29552418 |
Cytomegalovirus gastrointestinal infection | 79.16 | 15.66 | 20 | 21677 | 173 | 29552657 |
Pneumocystis jirovecii pneumonia | 76.58 | 15.66 | 77 | 21620 | 16702 | 29536128 |
Encephalitis cytomegalovirus | 72.84 | 15.66 | 23 | 21674 | 471 | 29552359 |
Cryptococcosis | 71.99 | 15.66 | 33 | 21664 | 1919 | 29550911 |
Liver transplant rejection | 71.64 | 15.66 | 33 | 21664 | 1941 | 29550889 |
Bone marrow failure | 71.09 | 15.66 | 94 | 21603 | 27355 | 29525475 |
Cytomegalovirus oesophagitis | 68.17 | 15.66 | 21 | 21676 | 395 | 29552435 |
Lung transplant rejection | 68.00 | 15.66 | 24 | 21673 | 700 | 29552130 |
Nephropathy toxic | 67.65 | 15.66 | 59 | 21638 | 10697 | 29542133 |
Pseudomonas infection | 67.19 | 15.66 | 59 | 21638 | 10793 | 29542037 |
Fall | 60.80 | 15.66 | 27 | 21670 | 177151 | 29375679 |
Glomerulosclerosis | 56.88 | 15.66 | 21 | 21676 | 699 | 29552131 |
Septic shock | 56.73 | 15.66 | 135 | 21562 | 62425 | 29490405 |
Focal segmental glomerulosclerosis | 55.72 | 15.66 | 27 | 21670 | 1780 | 29551050 |
Fatigue | 54.70 | 15.66 | 93 | 21604 | 316728 | 29236102 |
Lymphopenia | 54.36 | 15.66 | 58 | 21639 | 13475 | 29539355 |
Toxoplasmosis | 53.56 | 15.66 | 23 | 21674 | 1144 | 29551686 |
Polyomavirus viraemia | 51.53 | 15.66 | 19 | 21678 | 630 | 29552200 |
Large intestinal ulcer | 51.08 | 15.66 | 25 | 21672 | 1684 | 29551146 |
Mycobacterium avium complex infection | 49.91 | 15.66 | 27 | 21670 | 2242 | 29550588 |
Trichophytosis | 49.89 | 15.66 | 15 | 21682 | 259 | 29552571 |
Enterococcal infection | 49.29 | 15.66 | 44 | 21653 | 8224 | 29544606 |
Subcapsular renal haematoma | 48.51 | 15.66 | 16 | 21681 | 378 | 29552452 |
Kidney fibrosis | 46.82 | 15.66 | 25 | 21672 | 2022 | 29550808 |
Myocardial infarction | 46.13 | 15.66 | 12 | 21685 | 110284 | 29442546 |
Dizziness | 45.87 | 15.66 | 43 | 21654 | 189641 | 29363189 |
Fungal skin infection | 45.80 | 15.66 | 26 | 21671 | 2372 | 29550458 |
Infection reactivation | 45.25 | 15.66 | 20 | 21677 | 1067 | 29551763 |
Renal artery stenosis | 45.00 | 15.66 | 24 | 21673 | 1937 | 29550893 |
Cytopenia | 44.53 | 15.66 | 45 | 21652 | 9814 | 29543016 |
Transplant failure | 44.13 | 15.66 | 27 | 21670 | 2829 | 29550001 |
Viral load increased | 44.01 | 15.66 | 24 | 21673 | 2025 | 29550805 |
Somnolence | 43.79 | 15.66 | 8 | 21689 | 93947 | 29458883 |
Granulomatous dermatitis | 43.54 | 15.66 | 13 | 21684 | 219 | 29552611 |
Myelosuppression | 43.21 | 15.66 | 49 | 21648 | 12178 | 29540652 |
Product use in unapproved indication | 43.16 | 15.66 | 151 | 21546 | 86724 | 29466106 |
Escherichia urinary tract infection | 42.58 | 15.66 | 27 | 21670 | 3012 | 29549818 |
Pyrexia | 41.70 | 15.66 | 356 | 21341 | 287266 | 29265564 |
Lymphocele | 41.36 | 15.66 | 20 | 21677 | 1312 | 29551518 |
Pneumocystis jirovecii infection | 39.78 | 15.66 | 20 | 21677 | 1428 | 29551402 |
Pericarditis fungal | 39.06 | 15.66 | 11 | 21686 | 149 | 29552681 |
Renal tubular necrosis | 38.56 | 15.66 | 50 | 21647 | 14265 | 29538565 |
Clostridium difficile colitis | 38.52 | 15.66 | 48 | 21649 | 13164 | 29539666 |
Pain | 37.87 | 15.66 | 42 | 21655 | 171390 | 29381440 |
Candida infection | 37.66 | 15.66 | 51 | 21646 | 15174 | 29537656 |
Pain in extremity | 37.57 | 15.66 | 17 | 21680 | 110416 | 29442414 |
Tubulointerstitial nephritis | 37.56 | 15.66 | 55 | 21642 | 17588 | 29535242 |
Human ehrlichiosis | 36.48 | 15.66 | 11 | 21686 | 192 | 29552638 |
Hypogammaglobulinaemia | 36.33 | 15.66 | 32 | 21665 | 5875 | 29546955 |
Bronchopulmonary aspergillosis | 36.23 | 15.66 | 45 | 21652 | 12299 | 29540531 |
Disseminated cytomegaloviral infection | 36.16 | 15.66 | 11 | 21686 | 198 | 29552632 |
Vena cava injury | 35.70 | 15.66 | 11 | 21686 | 207 | 29552623 |
Dermatophytosis | 35.46 | 15.66 | 11 | 21686 | 212 | 29552618 |
Intraductal papillary mucinous neoplasm | 34.73 | 15.66 | 12 | 21685 | 328 | 29552502 |
JC virus infection | 34.70 | 15.66 | 20 | 21677 | 1877 | 29550953 |
Hepatic artery thrombosis | 34.57 | 15.66 | 11 | 21686 | 231 | 29552599 |
Product dose omission issue | 34.11 | 15.66 | 14 | 21683 | 96369 | 29456461 |
Botulism | 33.97 | 15.66 | 10 | 21687 | 160 | 29552670 |
Syncope | 33.73 | 15.66 | 9 | 21688 | 81362 | 29471468 |
Gene mutation | 33.44 | 15.66 | 16 | 21681 | 1025 | 29551805 |
Rectal prolapse | 33.35 | 15.66 | 11 | 21686 | 260 | 29552570 |
Viraemia | 32.97 | 15.66 | 16 | 21681 | 1058 | 29551772 |
Renal cyst haemorrhage | 32.68 | 15.66 | 12 | 21685 | 393 | 29552437 |
Renal tubular injury | 32.68 | 15.66 | 14 | 21683 | 692 | 29552138 |
Escherichia infection | 32.62 | 15.66 | 32 | 21665 | 6732 | 29546098 |
Thrombocytopenia | 32.48 | 15.66 | 189 | 21508 | 134634 | 29418196 |
Klebsiella infection | 32.20 | 15.66 | 33 | 21664 | 7316 | 29545514 |
Pulmonary nocardiosis | 32.17 | 15.66 | 13 | 21684 | 554 | 29552276 |
Cytomegalovirus hepatitis | 31.97 | 15.66 | 11 | 21686 | 297 | 29552533 |
Cytomegalovirus gastritis | 31.52 | 15.66 | 10 | 21687 | 208 | 29552622 |
Renal transplant failure | 31.25 | 15.66 | 15 | 21682 | 968 | 29551862 |
Liver transplant | 31.02 | 15.66 | 20 | 21677 | 2296 | 29550534 |
SARS-CoV-2 antibody test positive | 30.86 | 15.66 | 10 | 21687 | 223 | 29552607 |
Cell-mediated cytotoxicity | 30.38 | 15.66 | 7 | 21690 | 39 | 29552791 |
Gastritis fungal | 30.27 | 15.66 | 8 | 21689 | 84 | 29552746 |
Blood creatinine increased | 30.13 | 15.66 | 133 | 21564 | 84969 | 29467861 |
Disseminated trichosporonosis | 29.80 | 15.66 | 7 | 21690 | 43 | 29552787 |
Cystitis haemorrhagic | 29.32 | 15.66 | 26 | 21671 | 4816 | 29548014 |
Parvovirus B19 infection | 29.10 | 15.66 | 13 | 21684 | 711 | 29552119 |
Pulmonary mucormycosis | 29.03 | 15.66 | 12 | 21685 | 542 | 29552288 |
Retinal scar | 28.92 | 15.66 | 10 | 21687 | 274 | 29552556 |
Chronic papillomatous dermatitis | 28.89 | 15.66 | 7 | 21690 | 50 | 29552780 |
Fungal endocarditis | 28.75 | 15.66 | 10 | 21687 | 279 | 29552551 |
Glomerulonephropathy | 28.24 | 15.66 | 9 | 21688 | 190 | 29552640 |
Headache | 28.20 | 15.66 | 53 | 21644 | 173954 | 29378876 |
Fungal infection | 28.17 | 15.66 | 42 | 21655 | 13643 | 29539187 |
Cytomegalovirus nephritis | 27.97 | 15.66 | 8 | 21689 | 115 | 29552715 |
Progressive multifocal leukoencephalopathy | 27.56 | 15.66 | 33 | 21664 | 8686 | 29544144 |
Isosporiasis | 26.89 | 15.66 | 7 | 21690 | 69 | 29552761 |
Graft versus host disease | 26.51 | 15.66 | 34 | 21663 | 9594 | 29543236 |
Asthenia | 26.49 | 15.66 | 76 | 21621 | 215174 | 29337656 |
Granulomatous rosacea | 26.46 | 15.66 | 8 | 21689 | 141 | 29552689 |
Hyperparathyroidism | 26.32 | 15.66 | 14 | 21683 | 1123 | 29551707 |
Actinic keratosis | 26.31 | 15.66 | 22 | 21675 | 3764 | 29549066 |
Anxiety | 26.24 | 15.66 | 15 | 21682 | 85350 | 29467480 |
End stage renal disease | 25.87 | 15.66 | 30 | 21667 | 7634 | 29545196 |
Cardiac failure congestive | 25.70 | 15.66 | 12 | 21685 | 76569 | 29476261 |
Protothecosis | 25.66 | 15.66 | 6 | 21691 | 36 | 29552794 |
Malaise | 25.51 | 15.66 | 49 | 21648 | 159553 | 29393277 |
Hyperhidrosis | 25.16 | 15.66 | 8 | 21689 | 64532 | 29488298 |
Constipation | 25.15 | 15.66 | 28 | 21669 | 114132 | 29438698 |
Rash | 24.86 | 15.66 | 65 | 21632 | 189754 | 29363076 |
Depression | 24.72 | 15.66 | 16 | 21681 | 85131 | 29467699 |
Immune recovery uveitis | 24.70 | 15.66 | 5 | 21692 | 13 | 29552817 |
Feeling abnormal | 24.58 | 15.66 | 5 | 21692 | 54440 | 29498390 |
Thrombotic microangiopathy | 24.44 | 15.66 | 31 | 21666 | 8650 | 29544180 |
Gastrointestinal haemorrhage | 24.41 | 15.66 | 14 | 21683 | 79519 | 29473311 |
Odynophagia | 24.23 | 15.66 | 23 | 21674 | 4647 | 29548183 |
Multiple organ dysfunction syndrome | 24.14 | 15.66 | 101 | 21596 | 63015 | 29489815 |
Graft loss | 24.14 | 15.66 | 12 | 21685 | 836 | 29551994 |
Eye infection toxoplasmal | 24.06 | 15.66 | 8 | 21689 | 194 | 29552636 |
Enterovirus infection | 23.57 | 15.66 | 11 | 21686 | 666 | 29552164 |
Steroid diabetes | 23.55 | 15.66 | 15 | 21682 | 1686 | 29551144 |
Cerebral toxoplasmosis | 23.46 | 15.66 | 14 | 21683 | 1402 | 29551428 |
Myocarditis toxoplasmal | 23.44 | 15.66 | 6 | 21691 | 55 | 29552775 |
Human polyomavirus infection | 23.36 | 15.66 | 11 | 21686 | 680 | 29552150 |
Oesophagopleural fistula | 23.15 | 15.66 | 6 | 21691 | 58 | 29552772 |
Dyspnoea | 23.05 | 15.66 | 143 | 21554 | 326589 | 29226241 |
Type 3 diabetes mellitus | 22.68 | 15.66 | 5 | 21692 | 22 | 29552808 |
Toxic optic neuropathy | 22.63 | 15.66 | 11 | 21686 | 730 | 29552100 |
Acute kidney injury | 22.56 | 15.66 | 295 | 21402 | 264972 | 29287858 |
Optic discs blurred | 22.29 | 15.66 | 6 | 21691 | 68 | 29552762 |
Squamous cell carcinoma of skin | 22.28 | 15.66 | 31 | 21666 | 9455 | 29543375 |
Muscle spasms | 22.15 | 15.66 | 10 | 21687 | 65072 | 29487758 |
Biloma | 22.05 | 15.66 | 6 | 21691 | 71 | 29552759 |
Bacterial toxaemia | 22.04 | 15.66 | 7 | 21690 | 146 | 29552684 |
Dehiscence | 21.97 | 15.66 | 6 | 21691 | 72 | 29552758 |
Nausea | 21.77 | 15.66 | 124 | 21573 | 289131 | 29263699 |
Bacteraemia | 21.46 | 15.66 | 41 | 21656 | 16282 | 29536548 |
Anastomotic stenosis | 21.34 | 15.66 | 8 | 21689 | 278 | 29552552 |
Arthralgia | 21.33 | 15.66 | 44 | 21653 | 139573 | 29413257 |
Klebsiella sepsis | 21.23 | 15.66 | 14 | 21683 | 1670 | 29551160 |
Hydronephrosis | 21.21 | 15.66 | 29 | 21668 | 8701 | 29544129 |
Staphylococcal infection | 21.17 | 15.66 | 58 | 21639 | 29182 | 29523648 |
Urticaria | 20.91 | 15.66 | 7 | 21690 | 54653 | 29498177 |
Encephalitis viral | 20.88 | 15.66 | 12 | 21685 | 1120 | 29551710 |
Granuloma | 20.70 | 15.66 | 16 | 21681 | 2448 | 29550382 |
Heart transplant rejection | 20.70 | 15.66 | 12 | 21685 | 1139 | 29551691 |
Lung transplant | 20.69 | 15.66 | 14 | 21683 | 1742 | 29551088 |
Serum sickness | 20.63 | 15.66 | 14 | 21683 | 1751 | 29551079 |
Immunosuppressant drug level decreased | 20.63 | 15.66 | 12 | 21685 | 1146 | 29551684 |
Genitourinary tract infection | 20.27 | 15.66 | 6 | 21691 | 98 | 29552732 |
Sepsis | 20.25 | 15.66 | 176 | 21521 | 142506 | 29410324 |
IVth nerve paralysis | 19.99 | 15.66 | 6 | 21691 | 103 | 29552727 |
Epstein-Barr viraemia | 19.75 | 15.66 | 11 | 21686 | 967 | 29551863 |
Colitis | 19.73 | 15.66 | 59 | 21638 | 31189 | 29521641 |
Cutaneous mucormycosis | 19.57 | 15.66 | 6 | 21691 | 111 | 29552719 |
Neutrophilic dermatosis | 19.34 | 15.66 | 7 | 21690 | 220 | 29552610 |
Necrotising retinitis | 19.33 | 15.66 | 10 | 21687 | 758 | 29552072 |
Renal tubular atrophy | 19.11 | 15.66 | 11 | 21686 | 1030 | 29551800 |
Bronchial anastomosis complication | 19.10 | 15.66 | 4 | 21693 | 13 | 29552817 |
Thrombotic thrombocytopenic purpura | 18.98 | 15.66 | 17 | 21680 | 3189 | 29549641 |
Trichophytic granuloma | 18.88 | 15.66 | 5 | 21692 | 53 | 29552777 |
Drug intolerance | 18.85 | 15.66 | 6 | 21691 | 48373 | 29504457 |
Graft infection | 18.84 | 15.66 | 8 | 21689 | 387 | 29552443 |
Abscess | 18.73 | 15.66 | 29 | 21668 | 9733 | 29543097 |
Malignant neoplasm progression | 18.70 | 15.66 | 16 | 21681 | 73843 | 29478987 |
Urogenital infection bacterial | 18.63 | 15.66 | 5 | 21692 | 56 | 29552774 |
Drug level increased | 18.60 | 15.66 | 42 | 21655 | 18745 | 29534085 |
American trypanosomiasis | 18.57 | 15.66 | 7 | 21690 | 247 | 29552583 |
Abdominal wall haemorrhage | 18.52 | 15.66 | 7 | 21690 | 249 | 29552581 |
Meningitis cryptococcal | 18.44 | 15.66 | 14 | 21683 | 2086 | 29550744 |
Gait disturbance | 18.44 | 15.66 | 16 | 21681 | 73333 | 29479497 |
Viral mutation identified | 18.42 | 15.66 | 15 | 21682 | 2473 | 29550357 |
Rhabdomyolysis | 18.24 | 15.66 | 11 | 21686 | 60797 | 29492033 |
Carotid arteriosclerosis | 18.23 | 15.66 | 12 | 21685 | 1426 | 29551404 |
Encephalopathy | 18.09 | 15.66 | 57 | 21640 | 30986 | 29521844 |
Renal tubular disorder | 18.09 | 15.66 | 19 | 21678 | 4333 | 29548497 |
Joint swelling | 17.89 | 15.66 | 7 | 21690 | 49623 | 29503207 |
Post procedural bile leak | 17.86 | 15.66 | 7 | 21690 | 275 | 29552555 |
Blood creatine phosphokinase increased | 17.80 | 15.66 | 4 | 21693 | 40640 | 29512190 |
Lymphorrhoea | 17.74 | 15.66 | 5 | 21692 | 68 | 29552762 |
Nasopharyngitis | 17.61 | 15.66 | 11 | 21686 | 59654 | 29493176 |
Gastric fistula | 17.54 | 15.66 | 5 | 21692 | 71 | 29552759 |
Disseminated varicella zoster virus infection | 17.51 | 15.66 | 6 | 21691 | 160 | 29552670 |
Epistaxis | 17.50 | 15.66 | 8 | 21689 | 51696 | 29501134 |
Paraspinal abscess | 17.41 | 15.66 | 5 | 21692 | 73 | 29552757 |
Agitation | 17.27 | 15.66 | 8 | 21689 | 51296 | 29501534 |
Blastomycosis | 17.17 | 15.66 | 7 | 21690 | 305 | 29552525 |
Peripheral swelling | 17.15 | 15.66 | 13 | 21684 | 63726 | 29489104 |
Hyperparathyroidism secondary | 17.05 | 15.66 | 11 | 21686 | 1264 | 29551566 |
Mycobacterium fortuitum infection | 17.00 | 15.66 | 6 | 21691 | 175 | 29552655 |
Electrocardiogram QT prolonged | 16.99 | 15.66 | 3 | 21694 | 36134 | 29516696 |
Therapeutic product effect incomplete | 16.95 | 15.66 | 4 | 21693 | 39301 | 29513529 |
Retinal artery occlusion | 16.92 | 15.66 | 12 | 21685 | 1611 | 29551219 |
Fusarium infection | 16.89 | 15.66 | 10 | 21687 | 987 | 29551843 |
Pruritus | 16.86 | 15.66 | 38 | 21659 | 116811 | 29436019 |
Pneumonia fungal | 16.85 | 15.66 | 21 | 21676 | 5756 | 29547074 |
Hirsutism | 16.81 | 15.66 | 6 | 21691 | 181 | 29552649 |
Cerebrovascular accident | 16.78 | 15.66 | 19 | 21678 | 76892 | 29475938 |
Hepatitis viral | 16.74 | 15.66 | 8 | 21689 | 511 | 29552319 |
Neutropenic colitis | 16.74 | 15.66 | 14 | 21683 | 2397 | 29550433 |
Hypersensitivity | 16.68 | 15.66 | 9 | 21688 | 52894 | 29499936 |
Urinoma | 16.53 | 15.66 | 6 | 21691 | 190 | 29552640 |
Hyperplasia | 16.48 | 15.66 | 8 | 21689 | 529 | 29552301 |
Renal and pancreas transplant rejection | 16.45 | 15.66 | 4 | 21693 | 29 | 29552801 |
Graft complication | 16.36 | 15.66 | 7 | 21690 | 345 | 29552485 |
Graft versus host disease in skin | 16.32 | 15.66 | 16 | 21681 | 3363 | 29549467 |
Cytomegalovirus gastroenteritis | 16.18 | 15.66 | 6 | 21691 | 202 | 29552628 |
Donor specific antibody present | 16.18 | 15.66 | 5 | 21692 | 95 | 29552735 |
Meningitis fungal | 16.09 | 15.66 | 5 | 21692 | 97 | 29552733 |
Adenovirus infection | 16.01 | 15.66 | 18 | 21679 | 4429 | 29548401 |
Polycystic liver disease | 15.89 | 15.66 | 4 | 21693 | 34 | 29552796 |
Back pain | 15.81 | 15.66 | 32 | 21665 | 102252 | 29450578 |
Scopulariopsis infection | 15.76 | 15.66 | 5 | 21692 | 104 | 29552726 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cytomegalovirus infection | 1288.60 | 15.04 | 539 | 32319 | 36660 | 64429214 |
Cytomegalovirus viraemia | 998.66 | 15.04 | 323 | 32535 | 10505 | 64455369 |
Leukopenia | 814.31 | 15.04 | 553 | 32305 | 100689 | 64365185 |
Transplant rejection | 679.49 | 15.04 | 275 | 32583 | 17126 | 64448748 |
Drug resistance | 671.96 | 15.04 | 337 | 32521 | 34765 | 64431109 |
Pathogen resistance | 558.57 | 15.04 | 218 | 32640 | 12325 | 64453549 |
Neutropenia | 384.71 | 15.04 | 538 | 32320 | 239086 | 64226788 |
Polyomavirus-associated nephropathy | 375.07 | 15.04 | 127 | 32731 | 4761 | 64461113 |
Kidney transplant rejection | 359.78 | 15.04 | 147 | 32711 | 9364 | 64456510 |
BK virus infection | 327.00 | 15.04 | 128 | 32730 | 7284 | 64458590 |
Cytomegalovirus colitis | 285.49 | 15.04 | 98 | 32760 | 3830 | 64462044 |
Pancytopenia | 250.99 | 15.04 | 336 | 32522 | 142973 | 64322901 |
Immunosuppressant drug level increased | 240.20 | 15.04 | 102 | 32756 | 7157 | 64458717 |
Delayed graft function | 237.32 | 15.04 | 80 | 32778 | 2956 | 64462918 |
Cytomegalovirus chorioretinitis | 235.05 | 15.04 | 90 | 32768 | 4822 | 64461052 |
Transplant dysfunction | 234.45 | 15.04 | 98 | 32760 | 6610 | 64459264 |
Post transplant lymphoproliferative disorder | 231.90 | 15.04 | 108 | 32750 | 9436 | 64456438 |
Cytomegalovirus syndrome | 222.74 | 15.04 | 47 | 32811 | 251 | 64465623 |
Epstein-Barr virus infection | 215.77 | 15.04 | 112 | 32746 | 12376 | 64453498 |
Complications of transplanted kidney | 205.51 | 15.04 | 84 | 32774 | 5351 | 64460523 |
Agranulocytosis | 198.86 | 15.04 | 161 | 32697 | 38068 | 64427806 |
Pneumonia cytomegaloviral | 198.69 | 15.04 | 77 | 32781 | 4262 | 64461612 |
Mucormycosis | 193.78 | 15.04 | 88 | 32770 | 7253 | 64458621 |
Nocardiosis | 188.21 | 15.04 | 76 | 32782 | 4691 | 64461183 |
Cytomegalovirus infection reactivation | 187.52 | 15.04 | 80 | 32778 | 5676 | 64460198 |
Cytomegalovirus gastrointestinal infection | 176.55 | 15.04 | 42 | 32816 | 414 | 64465460 |
Encephalitis cytomegalovirus | 175.05 | 15.04 | 49 | 32809 | 956 | 64464918 |
Aspergillus infection | 164.34 | 15.04 | 103 | 32755 | 16276 | 64449598 |
Nephropathy toxic | 150.71 | 15.04 | 100 | 32758 | 17414 | 64448460 |
Renal impairment | 144.51 | 15.04 | 252 | 32606 | 134765 | 64331109 |
Lung transplant rejection | 136.11 | 15.04 | 43 | 32815 | 1289 | 64464585 |
Pneumocystis jirovecii pneumonia | 128.31 | 15.04 | 109 | 32749 | 27525 | 64438349 |
Fatigue | 122.55 | 15.04 | 121 | 32737 | 748609 | 63717265 |
Cryptococcosis | 115.96 | 15.04 | 46 | 32812 | 2709 | 64463165 |
Smooth muscle cell neoplasm | 114.18 | 15.04 | 34 | 32824 | 832 | 64465042 |
Pseudomonas infection | 114.02 | 15.04 | 85 | 32773 | 17798 | 64448076 |
Enterococcal infection | 106.96 | 15.04 | 74 | 32784 | 13792 | 64452082 |
Bronchopulmonary aspergillosis | 106.94 | 15.04 | 84 | 32774 | 19001 | 64446873 |
Pain | 104.38 | 15.04 | 78 | 32780 | 553433 | 63912441 |
Fall | 104.37 | 15.04 | 41 | 32817 | 416785 | 64049089 |
Renal tubular necrosis | 104.26 | 15.04 | 88 | 32770 | 22022 | 64443852 |
Human ehrlichiosis | 101.27 | 15.04 | 26 | 32832 | 359 | 64465515 |
Completed suicide | 100.59 | 15.04 | 3 | 32855 | 224411 | 64241463 |
Bone marrow failure | 100.40 | 15.04 | 123 | 32735 | 47829 | 64418045 |
Arthralgia | 99.00 | 15.04 | 51 | 32807 | 442209 | 64023665 |
Cytomegalovirus test positive | 97.15 | 15.04 | 49 | 32809 | 5095 | 64460779 |
Toxoplasmosis | 96.60 | 15.04 | 39 | 32819 | 2405 | 64463469 |
Renal transplant failure | 96.58 | 15.04 | 35 | 32823 | 1605 | 64464269 |
Graft versus host disease | 93.34 | 15.04 | 68 | 32790 | 13745 | 64452129 |
Lymphocele | 92.84 | 15.04 | 34 | 32824 | 1607 | 64464267 |
Immune reconstitution inflammatory syndrome | 92.56 | 15.04 | 65 | 32793 | 12405 | 64453469 |
Off label use | 90.69 | 15.04 | 591 | 32267 | 632215 | 63833659 |
Thrombotic microangiopathy | 90.51 | 15.04 | 72 | 32786 | 16583 | 64449291 |
Blood creatinine increased | 87.17 | 15.04 | 205 | 32653 | 135577 | 64330297 |
Cytomegalovirus enteritis | 86.33 | 15.04 | 26 | 32832 | 662 | 64465212 |
Dizziness | 85.78 | 15.04 | 57 | 32801 | 430106 | 64035768 |
Liver transplant rejection | 85.67 | 15.04 | 38 | 32820 | 2961 | 64462913 |
Escherichia infection | 85.50 | 15.04 | 67 | 32791 | 15101 | 64450773 |
Acute kidney injury | 85.24 | 15.04 | 452 | 32406 | 448788 | 64017086 |
Polyomavirus viraemia | 84.46 | 15.04 | 29 | 32829 | 1133 | 64464741 |
Septic shock | 84.45 | 15.04 | 174 | 32684 | 105263 | 64360611 |
Product use in unapproved indication | 83.82 | 15.04 | 238 | 32620 | 176380 | 64289494 |
Myelosuppression | 83.05 | 15.04 | 80 | 32778 | 23750 | 64442124 |
Renal artery stenosis | 82.83 | 15.04 | 37 | 32821 | 2932 | 64462942 |
Cytomegalovirus oesophagitis | 80.64 | 15.04 | 24 | 32834 | 586 | 64465288 |
Ureaplasma infection | 80.31 | 15.04 | 25 | 32833 | 713 | 64465161 |
Posterior reversible encephalopathy syndrome | 79.91 | 15.04 | 77 | 32781 | 22869 | 64443005 |
Cytopenia | 77.97 | 15.04 | 64 | 32794 | 15407 | 64450467 |
Transplant failure | 77.14 | 15.04 | 38 | 32820 | 3756 | 64462118 |
Thrombocytopenia | 75.43 | 15.04 | 268 | 32590 | 223533 | 64242341 |
Lymphopenia | 74.47 | 15.04 | 78 | 32780 | 25579 | 64440295 |
Pyrexia | 73.47 | 15.04 | 511 | 32347 | 558133 | 63907741 |
Strongyloidiasis | 69.00 | 15.04 | 33 | 32825 | 3057 | 64462817 |
Infection reactivation | 68.72 | 15.04 | 29 | 32829 | 2001 | 64463873 |
Mycobacterium avium complex infection | 67.08 | 15.04 | 35 | 32823 | 3905 | 64461969 |
Klebsiella infection | 67.05 | 15.04 | 55 | 32803 | 13226 | 64452648 |
Pain in extremity | 66.20 | 15.04 | 36 | 32822 | 303049 | 64162825 |
Viraemia | 64.65 | 15.04 | 29 | 32829 | 2320 | 64463554 |
Focal segmental glomerulosclerosis | 64.40 | 15.04 | 31 | 32827 | 2913 | 64462961 |
Joint swelling | 63.05 | 15.04 | 16 | 32842 | 215366 | 64250508 |
Malaise | 62.36 | 15.04 | 66 | 32792 | 396181 | 64069693 |
Cytomegalovirus gastritis | 61.96 | 15.04 | 18 | 32840 | 403 | 64465471 |
Hypersensitivity | 60.66 | 15.04 | 13 | 32845 | 196439 | 64269435 |
JC virus infection | 60.56 | 15.04 | 31 | 32827 | 3324 | 64462550 |
Headache | 60.56 | 15.04 | 111 | 32747 | 529356 | 63936518 |
Parvovirus B19 infection | 60.34 | 15.04 | 23 | 32835 | 1216 | 64464658 |
Pyelonephritis | 60.23 | 15.04 | 58 | 32800 | 17208 | 64448666 |
Product dose omission issue | 59.91 | 15.04 | 13 | 32845 | 194734 | 64271140 |
Dyspnoea | 59.57 | 15.04 | 179 | 32679 | 718495 | 63747379 |
Escherichia urinary tract infection | 59.00 | 15.04 | 49 | 32809 | 11988 | 64453886 |
Fungal skin infection | 58.48 | 15.04 | 35 | 32823 | 5090 | 64460784 |
Peripheral swelling | 58.47 | 15.04 | 17 | 32841 | 209136 | 64256738 |
Cystitis haemorrhagic | 57.95 | 15.04 | 41 | 32817 | 7915 | 64457959 |
Viral load increased | 56.88 | 15.04 | 27 | 32831 | 2460 | 64463414 |
Trichophytosis | 56.64 | 15.04 | 16 | 32842 | 323 | 64465551 |
Adenovirus infection | 56.61 | 15.04 | 39 | 32819 | 7216 | 64458658 |
Drug level increased | 54.91 | 15.04 | 77 | 32781 | 34119 | 64431755 |
Glomerulosclerosis | 54.61 | 15.04 | 20 | 32838 | 945 | 64464929 |
Pulmonary mucormycosis | 54.14 | 15.04 | 19 | 32839 | 793 | 64465081 |
Anxiety | 53.91 | 15.04 | 18 | 32840 | 202631 | 64263243 |
Graft loss | 53.78 | 15.04 | 20 | 32838 | 987 | 64464887 |
Subcapsular renal haematoma | 53.08 | 15.04 | 18 | 32840 | 677 | 64465197 |
Nasopharyngitis | 52.89 | 15.04 | 17 | 32841 | 196056 | 64269818 |
Feeling abnormal | 52.79 | 15.04 | 4 | 32854 | 133598 | 64332276 |
Pericarditis fungal | 51.72 | 15.04 | 13 | 32845 | 164 | 64465710 |
Kidney fibrosis | 51.23 | 15.04 | 27 | 32831 | 3074 | 64462800 |
Somnolence | 50.93 | 15.04 | 20 | 32838 | 203625 | 64262249 |
Eye infection toxoplasmal | 50.92 | 15.04 | 16 | 32842 | 471 | 64465403 |
Rash | 49.89 | 15.04 | 99 | 32759 | 458450 | 64007424 |
Death | 49.33 | 15.04 | 108 | 32750 | 482597 | 63983277 |
Disseminated cytomegaloviral infection | 48.79 | 15.04 | 15 | 32843 | 410 | 64465464 |
Sepsis | 47.87 | 15.04 | 238 | 32620 | 230103 | 64235771 |
Cytomegalovirus hepatitis | 47.45 | 15.04 | 16 | 32842 | 591 | 64465283 |
Tubulointerstitial nephritis | 47.27 | 15.04 | 68 | 32790 | 30841 | 64435033 |
Renal transplant | 47.15 | 15.04 | 23 | 32835 | 2225 | 64463649 |
Abdominal discomfort | 47.10 | 15.04 | 17 | 32841 | 182305 | 64283569 |
Drug hypersensitivity | 46.67 | 15.04 | 32 | 32826 | 237783 | 64228091 |
Infusion related reaction | 46.64 | 15.04 | 13 | 32845 | 164454 | 64301420 |
Multiple organ dysfunction syndrome | 46.44 | 15.04 | 135 | 32723 | 101278 | 64364596 |
Myocardial infarction | 45.39 | 15.04 | 14 | 32844 | 165807 | 64300067 |
Alopecia | 45.33 | 15.04 | 14 | 32844 | 165676 | 64300198 |
Pneumonia fungal | 45.31 | 15.04 | 37 | 32821 | 8840 | 64457034 |
Granulomatous rosacea | 44.81 | 15.04 | 12 | 32846 | 197 | 64465677 |
Hypogammaglobulinaemia | 44.50 | 15.04 | 39 | 32819 | 10260 | 64455614 |
Therapeutic product effect decreased | 44.06 | 15.04 | 4 | 32854 | 115347 | 64350527 |
Epstein-Barr virus infection reactivation | 44.00 | 15.04 | 18 | 32840 | 1148 | 64464726 |
Viral mutation identified | 43.85 | 15.04 | 25 | 32833 | 3321 | 64462553 |
Hyperammonaemia | 43.79 | 15.04 | 38 | 32820 | 9866 | 64456008 |
Adenoviral hepatitis | 43.26 | 15.04 | 14 | 32844 | 454 | 64465420 |
Clostridium difficile colitis | 43.26 | 15.04 | 61 | 32797 | 27162 | 64438712 |
Granulomatous dermatitis | 43.09 | 15.04 | 13 | 32845 | 333 | 64465541 |
Urticaria | 42.99 | 15.04 | 11 | 32847 | 147306 | 64318568 |
Drug intolerance | 42.99 | 15.04 | 21 | 32837 | 187971 | 64277903 |
Hydronephrosis | 42.89 | 15.04 | 44 | 32814 | 14081 | 64451793 |
Gene mutation | 42.77 | 15.04 | 21 | 32837 | 2061 | 64463813 |
Epstein-Barr viraemia | 42.60 | 15.04 | 20 | 32838 | 1777 | 64464097 |
Acinetobacter infection | 42.56 | 15.04 | 22 | 32836 | 2407 | 64463467 |
Serum sickness | 42.26 | 15.04 | 24 | 32834 | 3165 | 64462709 |
Liver transplant | 41.71 | 15.04 | 26 | 32832 | 4066 | 64461808 |
Nausea | 41.64 | 15.04 | 233 | 32625 | 785567 | 63680307 |
Oesophageal atresia | 41.48 | 15.04 | 9 | 32849 | 56 | 64465818 |
Brain abscess | 41.19 | 15.04 | 26 | 32832 | 4155 | 64461719 |
Depression | 41.12 | 15.04 | 21 | 32837 | 183270 | 64282604 |
Muscle spasms | 40.26 | 15.04 | 11 | 32847 | 141012 | 64324862 |
Systemic candida | 40.06 | 15.04 | 28 | 32830 | 5301 | 64460573 |
Back pain | 40.06 | 15.04 | 41 | 32817 | 250130 | 64215744 |
Candida infection | 39.36 | 15.04 | 63 | 32795 | 31356 | 64434518 |
Fungal infection | 39.29 | 15.04 | 66 | 32792 | 34185 | 64431689 |
Vena cava injury | 39.08 | 15.04 | 11 | 32847 | 219 | 64465655 |
Teratogenicity | 38.97 | 15.04 | 9 | 32849 | 77 | 64465797 |
Neutrophil Pelger-Huet anomaly present | 38.59 | 15.04 | 12 | 32846 | 341 | 64465533 |
Actinic keratosis | 38.51 | 15.04 | 27 | 32831 | 5138 | 64460736 |
Squamous cell carcinoma of skin | 37.89 | 15.04 | 38 | 32820 | 11838 | 64454036 |
Steroid diabetes | 37.87 | 15.04 | 21 | 32837 | 2645 | 64463229 |
Pneumocystis jirovecii infection | 37.43 | 15.04 | 20 | 32838 | 2341 | 64463533 |
Aplasia pure red cell | 37.42 | 15.04 | 30 | 32828 | 6984 | 64458890 |
Injection site pain | 37.31 | 15.04 | 6 | 32852 | 111402 | 64354472 |
Asthma | 37.19 | 15.04 | 3 | 32855 | 95222 | 64370652 |
Toxic optic neuropathy | 37.04 | 15.04 | 15 | 32843 | 932 | 64464942 |
Oral candidiasis | 36.86 | 15.04 | 52 | 32806 | 23160 | 64442714 |
Pericarditis constrictive | 36.76 | 15.04 | 13 | 32845 | 555 | 64465319 |
Pulmonary nocardiosis | 36.64 | 15.04 | 14 | 32844 | 745 | 64465129 |
Central nervous system fungal infection | 36.48 | 15.04 | 12 | 32846 | 410 | 64465464 |
Contusion | 36.29 | 15.04 | 7 | 32851 | 113958 | 64351916 |
Scedosporium infection | 36.17 | 15.04 | 16 | 32842 | 1238 | 64464636 |
Hepatic artery thrombosis | 36.09 | 15.04 | 11 | 32847 | 292 | 64465582 |
Heart transplant rejection | 35.78 | 15.04 | 16 | 32842 | 1271 | 64464603 |
Renal cyst haemorrhage | 35.42 | 15.04 | 12 | 32846 | 450 | 64465424 |
Graft versus host disease in skin | 35.39 | 15.04 | 26 | 32832 | 5321 | 64460553 |
Cerebrovascular accident | 35.24 | 15.04 | 13 | 32845 | 137570 | 64328304 |
Pruritus | 35.19 | 15.04 | 66 | 32792 | 312334 | 64153540 |
Hyperuricaemia | 35.10 | 15.04 | 34 | 32824 | 10157 | 64455717 |
Swelling | 34.99 | 15.04 | 19 | 32839 | 160199 | 64305675 |
Colitis | 34.82 | 15.04 | 86 | 32772 | 58588 | 64407286 |
Hyperkalaemia | 34.77 | 15.04 | 122 | 32736 | 101007 | 64364867 |
Encephalitis viral | 34.50 | 15.04 | 19 | 32839 | 2361 | 64463513 |
Fungal endocarditis | 34.39 | 15.04 | 12 | 32846 | 492 | 64465382 |
Oesophageal candidiasis | 33.92 | 15.04 | 30 | 32828 | 7987 | 64457887 |
Large intestinal ulcer | 33.80 | 15.04 | 23 | 32835 | 4170 | 64461704 |
SARS-CoV-2 antibody test positive | 33.80 | 15.04 | 10 | 32848 | 239 | 64465635 |
Cytomegalovirus nephritis | 33.76 | 15.04 | 9 | 32849 | 145 | 64465729 |
Cerebral toxoplasmosis | 33.33 | 15.04 | 17 | 32841 | 1809 | 64464065 |
Haemolytic anaemia | 33.29 | 15.04 | 41 | 32817 | 16012 | 64449862 |
Renal tubular atrophy | 33.14 | 15.04 | 16 | 32842 | 1513 | 64464361 |
Anaemia | 33.09 | 15.04 | 316 | 32542 | 378364 | 64087510 |
Weight increased | 32.99 | 15.04 | 36 | 32822 | 213312 | 64252562 |
Constipation | 32.99 | 15.04 | 41 | 32817 | 229296 | 64236578 |
Adrenal mass | 32.94 | 15.04 | 14 | 32844 | 983 | 64464891 |
Dermatophytosis | 32.92 | 15.04 | 11 | 32847 | 395 | 64465479 |
Musculoskeletal stiffness | 32.65 | 15.04 | 11 | 32847 | 123195 | 64342679 |
Intraductal papillary mucinous neoplasm | 32.41 | 15.04 | 12 | 32846 | 585 | 64465289 |
Cell-mediated cytotoxicity | 32.34 | 15.04 | 7 | 32851 | 43 | 64465831 |
Cytomegalovirus gastroenteritis | 32.33 | 15.04 | 11 | 32847 | 418 | 64465456 |
Febrile neutropenia | 32.20 | 15.04 | 184 | 32674 | 187473 | 64278401 |
Blood pressure increased | 31.53 | 15.04 | 25 | 32833 | 172527 | 64293347 |
Syncope | 31.19 | 15.04 | 21 | 32837 | 157614 | 64308260 |
Diabetes mellitus | 30.91 | 15.04 | 89 | 32769 | 66385 | 64399489 |
Renal tubular injury | 30.89 | 15.04 | 14 | 32844 | 1147 | 64464727 |
Progressive multifocal leukoencephalopathy | 30.68 | 15.04 | 42 | 32816 | 18190 | 64447684 |
Granuloma | 30.41 | 15.04 | 26 | 32832 | 6615 | 64459259 |
Respiratory failure | 30.29 | 15.04 | 162 | 32696 | 161021 | 64304853 |
Gait disturbance | 30.15 | 15.04 | 26 | 32832 | 172129 | 64293745 |
Botulism | 30.15 | 15.04 | 10 | 32848 | 351 | 64465523 |
Hyperhidrosis | 30.03 | 15.04 | 13 | 32845 | 124907 | 64340967 |
Donor specific antibody present | 30 | 15.04 | 9 | 32849 | 226 | 64465648 |
Bacteraemia | 29.73 | 15.04 | 51 | 32807 | 26860 | 64439014 |
Arthritis | 29.25 | 15.04 | 4 | 32854 | 83810 | 64382064 |
Retinal scar | 29.24 | 15.04 | 10 | 32848 | 386 | 64465488 |
Microsporidia infection | 29.22 | 15.04 | 12 | 32846 | 773 | 64465101 |
Guillain-Barre syndrome | 29.21 | 15.04 | 27 | 32831 | 7608 | 64458266 |
Chronic papillomatous dermatitis | 29.15 | 15.04 | 7 | 32851 | 72 | 64465802 |
Hepatocellular injury | 28.66 | 15.04 | 68 | 32790 | 45167 | 64420707 |
Glomerulonephritis | 28.33 | 15.04 | 18 | 32840 | 2910 | 64462964 |
Disseminated trichosporonosis | 28.17 | 15.04 | 7 | 32851 | 84 | 64465790 |
Chest discomfort | 28.04 | 15.04 | 12 | 32846 | 116094 | 64349780 |
Protothecosis | 27.98 | 15.04 | 6 | 32852 | 35 | 64465839 |
Glomerulonephropathy | 27.84 | 15.04 | 9 | 32849 | 291 | 64465583 |
Cardiac failure congestive | 27.76 | 15.04 | 16 | 32842 | 130564 | 64335310 |
Superinfection bacterial | 27.46 | 15.04 | 13 | 32845 | 1177 | 64464697 |
Odynophagia | 27.42 | 15.04 | 29 | 32829 | 9612 | 64456262 |
Gastritis fungal | 27.29 | 15.04 | 8 | 32850 | 185 | 64465689 |
Urosepsis | 27.26 | 15.04 | 44 | 32814 | 22050 | 64443824 |
End stage renal disease | 27.15 | 15.04 | 30 | 32828 | 10445 | 64455429 |
Cervicitis | 27.09 | 15.04 | 8 | 32850 | 190 | 64465684 |
Blastomycosis | 27.08 | 15.04 | 10 | 32848 | 484 | 64465390 |
Escherichia sepsis | 26.76 | 15.04 | 25 | 32833 | 7140 | 64458734 |
Mycobacterium fortuitum infection | 26.55 | 15.04 | 8 | 32850 | 204 | 64465670 |
Immune recovery uveitis | 26.52 | 15.04 | 5 | 32853 | 13 | 64465861 |
Loss of personal independence in daily activities | 26.40 | 15.04 | 3 | 32855 | 72451 | 64393423 |
Isosporiasis | 26.30 | 15.04 | 7 | 32851 | 112 | 64465762 |
Hyperparathyroidism | 26.27 | 15.04 | 17 | 32841 | 2835 | 64463039 |
Suicide attempt | 25.72 | 15.04 | 3 | 32855 | 71004 | 64394870 |
Trichophytic granuloma | 25.42 | 15.04 | 6 | 32852 | 57 | 64465817 |
Acute graft versus host disease | 25.26 | 15.04 | 27 | 32831 | 9057 | 64456817 |
Myocarditis toxoplasmal | 25.14 | 15.04 | 6 | 32852 | 60 | 64465814 |
Complications of transplanted lung | 25.04 | 15.04 | 9 | 32849 | 403 | 64465471 |
Electrocardiogram QT prolonged | 25.04 | 15.04 | 5 | 32853 | 79443 | 64386431 |
Prostatitis | 24.92 | 15.04 | 18 | 32840 | 3588 | 64462286 |
Epstein-Barr virus associated lymphoproliferative disorder | 24.89 | 15.04 | 17 | 32841 | 3102 | 64462772 |
Obliterative bronchiolitis | 24.83 | 15.04 | 16 | 32842 | 2649 | 64463225 |
Venous haemorrhage | 24.76 | 15.04 | 8 | 32850 | 258 | 64465616 |
Graft infection | 24.70 | 15.04 | 10 | 32848 | 621 | 64465253 |
Staphylococcal infection | 24.68 | 15.04 | 69 | 32789 | 50609 | 64415265 |
Maternal exposure during pregnancy | 24.65 | 15.04 | 9 | 32849 | 95875 | 64369999 |
Septal panniculitis | 24.54 | 15.04 | 6 | 32852 | 67 | 64465807 |
Optic discs blurred | 24.46 | 15.04 | 6 | 32852 | 68 | 64465806 |
Urate nephropathy | 24.43 | 15.04 | 7 | 32851 | 149 | 64465725 |
Left ventricular hypertrophy | 24.25 | 15.04 | 27 | 32831 | 9479 | 64456395 |
Bacterial toxaemia | 24.12 | 15.04 | 7 | 32851 | 156 | 64465718 |
Pleural mesothelioma malignant | 23.87 | 15.04 | 7 | 32851 | 162 | 64465712 |
Intentional product use issue | 23.79 | 15.04 | 104 | 32754 | 95260 | 64370614 |
Graft versus host disease in gastrointestinal tract | 23.74 | 15.04 | 21 | 32837 | 5591 | 64460283 |
Pancreatic pseudoaneurysm | 23.70 | 15.04 | 6 | 32852 | 78 | 64465796 |
Complications of transplant surgery | 23.17 | 15.04 | 10 | 32848 | 729 | 64465145 |
Meningitis cryptococcal | 23.06 | 15.04 | 16 | 32842 | 2993 | 64462881 |
Haemophagocytic lymphohistiocytosis | 23.01 | 15.04 | 36 | 32822 | 17573 | 64448301 |
Reticulocytopenia | 22.99 | 15.04 | 7 | 32851 | 185 | 64465689 |
Type 3 diabetes mellitus | 22.79 | 15.04 | 5 | 32853 | 33 | 64465841 |
Urogenital infection bacterial | 22.72 | 15.04 | 6 | 32852 | 93 | 64465781 |
Flushing | 22.69 | 15.04 | 6 | 32852 | 78642 | 64387232 |
Necrotising retinitis | 22.67 | 15.04 | 11 | 32847 | 1052 | 64464822 |
Renal tubular disorder | 22.57 | 15.04 | 21 | 32837 | 5966 | 64459908 |
Bacterial pyelonephritis | 22.52 | 15.04 | 9 | 32849 | 540 | 64465334 |
Blood pressure decreased | 22.31 | 15.04 | 8 | 32850 | 86191 | 64379683 |
Immunosuppressant drug level decreased | 22.29 | 15.04 | 13 | 32845 | 1802 | 64464072 |
Systemic lupus erythematosus | 22.24 | 15.04 | 6 | 32852 | 77606 | 64388268 |
Bacterial sepsis | 22.22 | 15.04 | 23 | 32835 | 7434 | 64458440 |
Mobility decreased | 22.16 | 15.04 | 8 | 32850 | 85832 | 64380042 |
Osteoarthritis | 22.15 | 15.04 | 3 | 32855 | 63333 | 64402541 |
Enterovirus infection | 22.14 | 15.04 | 12 | 32846 | 1445 | 64464429 |
Insomnia | 22.07 | 15.04 | 42 | 32816 | 197794 | 64268080 |
Rhinovirus infection | 22.07 | 15.04 | 21 | 32837 | 6135 | 64459739 |
Pneumonia pseudomonal | 22.05 | 15.04 | 19 | 32839 | 4884 | 64460990 |
Herpes simplex | 21.99 | 15.04 | 27 | 32831 | 10509 | 64455365 |
Superinfection viral | 21.95 | 15.04 | 5 | 32853 | 40 | 64465834 |
Palpitations | 21.93 | 15.04 | 13 | 32845 | 104475 | 64361399 |
Migraine | 21.85 | 15.04 | 3 | 32855 | 62674 | 64403200 |
Dehiscence | 21.83 | 15.04 | 6 | 32852 | 109 | 64465765 |
Discomfort | 21.81 | 15.04 | 7 | 32851 | 80871 | 64385003 |
Chronic graft versus host disease | 21.73 | 15.04 | 21 | 32837 | 6255 | 64459619 |
Oropharyngeal candidiasis | 21.70 | 15.04 | 12 | 32846 | 1503 | 64464371 |
Therapeutic product effect incomplete | 21.54 | 15.04 | 13 | 32845 | 103469 | 64362405 |
Renal lymphocele | 21.53 | 15.04 | 6 | 32852 | 115 | 64465759 |
Angioedema | 21.45 | 15.04 | 3 | 32855 | 61818 | 64404056 |
Clostridium difficile infection | 21.45 | 15.04 | 53 | 32805 | 36110 | 64429764 |
Muscular weakness | 21.37 | 15.04 | 20 | 32838 | 127318 | 64338556 |
Urinary tract infection bacterial | 21.34 | 15.04 | 19 | 32839 | 5102 | 64460772 |
Rhabdomyolysis | 21.33 | 15.04 | 10 | 32848 | 91716 | 64374158 |
Tonic clonic movements | 21.19 | 15.04 | 13 | 32845 | 1976 | 64463898 |
Delayed engraftment | 21.12 | 15.04 | 7 | 32851 | 245 | 64465629 |
Cutaneous mucormycosis | 21.11 | 15.04 | 6 | 32852 | 124 | 64465750 |
Herpes simplex viraemia | 20.99 | 15.04 | 7 | 32851 | 250 | 64465624 |
Drug level fluctuating | 20.81 | 15.04 | 9 | 32849 | 660 | 64465214 |
Lung transplant | 20.71 | 15.04 | 17 | 32841 | 4091 | 64461783 |
Oesophagopleural fistula | 20.69 | 15.04 | 5 | 32853 | 53 | 64465821 |
Ascites | 20.61 | 15.04 | 74 | 32784 | 61927 | 64403947 |
Memory impairment | 20.46 | 15.04 | 9 | 32849 | 85673 | 64380201 |
Disseminated tuberculosis | 20.32 | 15.04 | 16 | 32842 | 3629 | 64462245 |
Epstein-Barr virus test positive | 20.30 | 15.04 | 10 | 32848 | 988 | 64464886 |
Anaphylactic reaction | 20.27 | 15.04 | 5 | 32853 | 68659 | 64397215 |
Post procedural urine leak | 20.22 | 15.04 | 6 | 32852 | 145 | 64465729 |
Cytomegalovirus myocarditis | 20.11 | 15.04 | 4 | 32854 | 15 | 64465859 |
Human polyomavirus infection | 20.10 | 15.04 | 10 | 32848 | 1009 | 64464865 |
Inappropriate schedule of product administration | 20.06 | 15.04 | 11 | 32847 | 92275 | 64373599 |
Biloma | 19.99 | 15.04 | 6 | 32852 | 151 | 64465723 |
Asthenia | 19.91 | 15.04 | 132 | 32726 | 427912 | 64037962 |
Venoocclusive liver disease | 19.84 | 15.04 | 25 | 32833 | 9990 | 64455884 |
Malignant neoplasm progression | 19.81 | 15.04 | 17 | 32841 | 112854 | 64353020 |
Balance disorder | 19.75 | 15.04 | 9 | 32849 | 83917 | 64381957 |
Cytomegalovirus test negative | 19.75 | 15.04 | 3 | 32855 | 0 | 64465874 |
IVth nerve paralysis | 19.52 | 15.04 | 6 | 32852 | 164 | 64465710 |
Perinephric collection | 19.42 | 15.04 | 7 | 32851 | 316 | 64465558 |
Periostitis | 19.28 | 15.04 | 8 | 32850 | 529 | 64465345 |
Retinal detachment | 19.23 | 15.04 | 22 | 32836 | 7954 | 64457920 |
American trypanosomiasis | 19.19 | 15.04 | 7 | 32851 | 327 | 64465547 |
Neutropenic colitis | 19.10 | 15.04 | 17 | 32841 | 4564 | 64461310 |
Neuropathy peripheral | 19.09 | 15.04 | 19 | 32839 | 117506 | 64348368 |
Anorexia nervosa | 19.08 | 15.04 | 6 | 32852 | 177 | 64465697 |
Oxygen saturation decreased | 18.98 | 15.04 | 16 | 32842 | 107160 | 64358714 |
Chronic allograft nephropathy | 18.96 | 15.04 | 11 | 32847 | 1510 | 64464364 |
Bronchial anastomosis complication | 18.86 | 15.04 | 4 | 32854 | 22 | 64465852 |
Loss of consciousness | 18.84 | 15.04 | 29 | 32829 | 148336 | 64317538 |
Polycystic liver disease | 18.56 | 15.04 | 5 | 32853 | 84 | 64465790 |
Thyroid tuberculosis | 18.56 | 15.04 | 4 | 32854 | 24 | 64465850 |
Escherichia bacteraemia | 18.56 | 15.04 | 18 | 32840 | 5385 | 64460489 |
Parvovirus infection | 18.50 | 15.04 | 8 | 32850 | 586 | 64465288 |
Post procedural bile leak | 18.42 | 15.04 | 7 | 32851 | 367 | 64465507 |
Heart rate increased | 18.39 | 15.04 | 14 | 32844 | 98661 | 64367213 |
Pneumonia influenzal | 18.37 | 15.04 | 13 | 32845 | 2509 | 64463365 |
Sleep disorder | 18.31 | 15.04 | 4 | 32854 | 59705 | 64406169 |
Oesophageal ulcer | 18.23 | 15.04 | 19 | 32839 | 6191 | 64459683 |
Hepatitis viral | 18.21 | 15.04 | 9 | 32849 | 896 | 64464978 |
Coronavirus infection | 18.20 | 15.04 | 18 | 32840 | 5512 | 64460362 |
Epistaxis | 18.19 | 15.04 | 14 | 32844 | 98117 | 64367757 |
Carotid arteriosclerosis | 18.19 | 15.04 | 12 | 32846 | 2067 | 64463807 |
Proteus infection | 18.17 | 15.04 | 11 | 32847 | 1632 | 64464242 |
Viral uveitis | 18.03 | 15.04 | 5 | 32853 | 94 | 64465780 |
Abscess | 18.02 | 15.04 | 34 | 32824 | 19270 | 64446604 |
Enterobacter infection | 18.01 | 15.04 | 15 | 32843 | 3681 | 64462193 |
Mesothelioma malignant | 17.92 | 15.04 | 6 | 32852 | 217 | 64465657 |
Chest pain | 17.89 | 15.04 | 61 | 32797 | 235919 | 64229955 |
Klebsiella sepsis | 17.87 | 15.04 | 13 | 32845 | 2619 | 64463255 |
Rectal prolapse | 17.67 | 15.04 | 11 | 32847 | 1715 | 64464159 |
Pneumonia pneumococcal | 17.61 | 15.04 | 14 | 32844 | 3220 | 64462654 |
Meningitis viral | 17.60 | 15.04 | 11 | 32847 | 1727 | 64464147 |
Corynebacterium infection | 17.59 | 15.04 | 9 | 32849 | 964 | 64464910 |
Abdominal wall haemorrhage | 17.55 | 15.04 | 7 | 32851 | 418 | 64465456 |
Stomatitis | 17.48 | 15.04 | 18 | 32840 | 109587 | 64356287 |
Neck pain | 17.18 | 15.04 | 5 | 32853 | 61528 | 64404346 |
Agitation | 17.17 | 15.04 | 12 | 32846 | 88355 | 64377519 |
Pyelonephritis fungal | 17.17 | 15.04 | 5 | 32853 | 113 | 64465761 |
Scopulariopsis infection | 17.12 | 15.04 | 5 | 32853 | 114 | 64465760 |
Pulmonary interstitial emphysema syndrome | 16.97 | 15.04 | 7 | 32851 | 456 | 64465418 |
Herpes simplex oesophagitis | 16.97 | 15.04 | 6 | 32852 | 256 | 64465618 |
Hyperparathyroidism secondary | 16.95 | 15.04 | 12 | 32846 | 2318 | 64463556 |
Haemolytic uraemic syndrome | 16.92 | 15.04 | 15 | 32843 | 4006 | 64461868 |
Pneumonia klebsiella | 16.86 | 15.04 | 15 | 32843 | 4022 | 64461852 |
Pericarditis infective | 16.84 | 15.04 | 5 | 32853 | 121 | 64465753 |
Dyspepsia | 16.84 | 15.04 | 10 | 32848 | 80302 | 64385572 |
Dry mouth | 16.70 | 15.04 | 5 | 32853 | 60413 | 64405461 |
Parainfluenzae virus infection | 16.67 | 15.04 | 16 | 32842 | 4727 | 64461147 |
Disseminated varicella zoster virus infection | 16.62 | 15.04 | 6 | 32852 | 272 | 64465602 |
Lymphadenitis viral | 16.58 | 15.04 | 4 | 32854 | 42 | 64465832 |
Oesophagogastroscopy normal | 16.46 | 15.04 | 3 | 32855 | 6 | 64465868 |
Abdominal pain upper | 16.35 | 15.04 | 41 | 32817 | 174989 | 64290885 |
Adenoviral haemorrhagic cystitis | 16.30 | 15.04 | 7 | 32851 | 504 | 64465370 |
Urinary tract infection | 16.27 | 15.04 | 185 | 32673 | 231411 | 64234463 |
Subcutaneous abscess | 16.24 | 15.04 | 19 | 32839 | 7034 | 64458840 |
Human herpesvirus 6 infection reactivation | 16.23 | 15.04 | 6 | 32852 | 291 | 64465583 |
Renal and pancreas transplant rejection | 16.17 | 15.04 | 4 | 32854 | 47 | 64465827 |
Cholestasis | 16.16 | 15.04 | 55 | 32803 | 44817 | 64421057 |
Antiviral drug level above therapeutic | 16.10 | 15.04 | 4 | 32854 | 48 | 64465826 |
Fusarium infection | 16.07 | 15.04 | 10 | 32848 | 1559 | 64464315 |
Brain oedema | 15.99 | 15.04 | 35 | 32823 | 22040 | 64443834 |
Suicidal ideation | 15.87 | 15.04 | 7 | 32851 | 66535 | 64399339 |
Neutrophilic dermatosis | 15.75 | 15.04 | 7 | 32851 | 548 | 64465326 |
Blister | 15.72 | 15.04 | 11 | 32847 | 80956 | 64384918 |
Gastric fistula | 15.70 | 15.04 | 5 | 32853 | 154 | 64465720 |
Confusional state | 15.68 | 15.04 | 74 | 32784 | 261070 | 64204804 |
Hypervolaemia | 15.66 | 15.04 | 49 | 32809 | 38236 | 64427638 |
Wheezing | 15.58 | 15.04 | 11 | 32847 | 80568 | 64385306 |
Drug interaction | 15.57 | 15.04 | 265 | 32593 | 361818 | 64104056 |
Hepatic cyst infection | 15.54 | 15.04 | 5 | 32853 | 159 | 64465715 |
Speech disorder | 15.36 | 15.04 | 3 | 32855 | 48438 | 64417436 |
Bacterial infection | 15.25 | 15.04 | 37 | 32821 | 24913 | 64440961 |
Paraspinal abscess | 15.17 | 15.04 | 5 | 32853 | 172 | 64465702 |
Hypoaesthesia | 15.10 | 15.04 | 30 | 32828 | 139078 | 64326796 |
Hypophosphataemia | 15.09 | 15.04 | 27 | 32831 | 14693 | 64451181 |
None
Source | Code | Description |
---|---|---|
ATC | J05AB14 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleosides and nucleotides excl. reverse transcriptase inhibitors |
FDA MoA | N0000020060 | DNA Polymerase Inhibitors |
FDA EXT | N0000175459 | Nucleoside Analog |
FDA EPC | N0000175461 | Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000998 | Antiviral Agents |
CHEBI has role | CHEBI:36044 | antiviral drugs |
CHEBI has role | CHEBI:50266 | Prodrugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Prevention of CMV Disease After Kidney Transplantation | indication | ||
CMV Retinitis in AIDS Patients | indication | ||
Prevention of CMV Disease After Cardiac Transplantation | indication | ||
Prevention of CMV Disease After Kidney-Pancreas Transplantation | indication | ||
Prevention of Cytomegalovirus Disease | off-label use | ||
Dehydration | contraindication | 34095006 | |
Acute nephropathy | contraindication | 58574008 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Anemia | contraindication | 271737000 | DOID:2355 |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Aplastic anemia | contraindication | 306058006 | DOID:12449 |
Breastfeeding (mother) | contraindication | 413712001 | |
Granulocytopenic disorder | contraindication | 417672002 | |
Severe Bone Marrow Depression | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.97 | acidic |
pKa2 | 11.83 | acidic |
pKa3 | 7.81 | Basic |
pKa4 | 3.68 | Basic |
pKa5 | 2.12 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
DNA polymerase catalytic subunit | Enzyme | INHIBITOR | DRUGBANK | CHEMBL |
ID | Source |
---|---|
4021263 | VUID |
N0000148704 | NUI |
D02495 | KEGG_DRUG |
4021263 | VANDF |
4021264 | VANDF |
4030204 | VANDF |
C0909381 | UMLSCUI |
CHEBI:63635 | CHEBI |
CHEMBL1201314 | ChEMBL_ID |
CHEMBL252321 | ChEMBL_ID |
CHEMBL400177 | ChEMBL_ID |
DB01610 | DRUGBANK_ID |
CHEMBL1200454 | ChEMBL_ID |
D000077562 | MESH_DESCRIPTOR_UI |
135413535 | PUBCHEM_CID |
4716 | IUPHAR_LIGAND_ID |
7650 | INN_ID |
GCU97FKN3R | UNII |
275891 | RXNORM |
15960 | MMSL |
231338 | MMSL |
d04755 | MMSL |
009135 | NDDF |
009136 | NDDF |
129476000 | SNOMEDCT_US |
395266000 | SNOMEDCT_US |
412326001 | SNOMEDCT_US |
175865-60-8 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Valcyte | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0038 | TABLET, FILM COATED | 450 mg | ORAL | NDA | 31 sections |
Valcyte | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0004-0039 | POWDER, FOR SOLUTION | 50 mg | ORAL | NDA | 31 sections |
Valganciclovir hydrochloride for Oral | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2579 | POWDER, FOR SOLUTION | 50 mg | ORAL | ANDA | 29 sections |
Valganciclovir hydrochloride for Oral | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0591-2579 | POWDER, FOR SOLUTION | 50 mg | ORAL | ANDA | 29 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0603-6330 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 32 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6796 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-765 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
Valganciclovir | Human Prescription Drug Label | 1 | 27241-158 | TABLET | 450 mg | ORAL | ANDA | 28 sections |
Valganciclovir hydrochloride | Human Prescription Drug Label | 1 | 27241-159 | POWDER, FOR SOLUTION | 50 mg | ORAL | ANDA | 28 sections |
Valganciclovir | Human Prescription Drug Label | 1 | 31722-832 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-875 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 29 sections |
valganciclovir hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-356 | TABLET | 450 mg | ORAL | ANDA | 28 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 48433-124 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-787 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-762 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60429-846 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60429-846 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2288 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 31 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-2288 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 31 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63739-076 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 26 sections |
VALGANCICLOVIR HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63739-357 | TABLET | 450 mg | ORAL | ANDA | 29 sections |
VALGANCICLOVIR HYDROCHLORIDE | Human Prescription Drug Label | 1 | 65862-753 | TABLET | 450 mg | ORAL | ANDA | 28 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68084-965 | TABLET, FILM COATED | 450 mg | ORAL | ANDA | 29 sections |
Valganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 69097-277 | TABLET | 450 mg | ORAL | ANDA | 27 sections |
VALGANCICLOVIR HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70010-051 | FOR SOLUTION | 50 mg | ORAL | ANDA | 28 sections |
VALGANCICLOVIR HYDROCHLORIDE | Human Prescription Drug Label | 1 | 70069-810 | FOR SOLUTION | 50 mg | ORAL | ANDA | 28 sections |
VALGANCICLOVIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71151-003 | FOR SOLUTION | 50 mg | ORAL | ANDA | 30 sections |