ganciclovir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antivirals bicyclic heterocycle compounds | 1277 | 82410-32-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 3 | g | O |
| 0.50 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 3 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 91 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 78.36 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 4 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 4.60 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.99 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 3.70 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 23, 1989 | FDA | ROCHE PALO |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cytomegalovirus infection | 524.43 | 22.95 | 182 | 11521 | 20770 | 63456549 |
| Drug resistance | 456.02 | 22.95 | 168 | 11535 | 22765 | 63454554 |
| Post transplant lymphoproliferative disorder | 318.46 | 22.95 | 89 | 11614 | 4942 | 63472377 |
| Pathogen resistance | 306.00 | 22.95 | 91 | 11612 | 6307 | 63471012 |
| Cytomegalovirus viraemia | 299.37 | 22.95 | 87 | 11616 | 5562 | 63471757 |
| Smooth muscle cell neoplasm | 274.10 | 22.95 | 56 | 11647 | 785 | 63476534 |
| Epstein-Barr virus infection | 264.92 | 22.95 | 86 | 11617 | 7964 | 63469355 |
| Multiple organ dysfunction syndrome | 242.19 | 22.95 | 143 | 11560 | 56609 | 63420710 |
| Encephalitis cytomegalovirus | 216.48 | 22.95 | 43 | 11660 | 518 | 63476801 |
| Graft versus host disease | 173.83 | 22.95 | 60 | 11643 | 6703 | 63470616 |
| Off label use | 166.07 | 22.95 | 375 | 11328 | 674087 | 62803232 |
| Pancytopenia | 150.40 | 22.95 | 132 | 11571 | 96801 | 63380518 |
| Cytomegalovirus infection reactivation | 145.38 | 22.95 | 46 | 11657 | 3917 | 63473402 |
| Nephropathy toxic | 140.04 | 22.95 | 56 | 11647 | 9423 | 63467896 |
| Neutropenia | 135.68 | 22.95 | 164 | 11539 | 174841 | 63302478 |
| Pneumonia cytomegaloviral | 134.75 | 22.95 | 38 | 11665 | 2176 | 63475143 |
| Leukopenia | 129.47 | 22.95 | 110 | 11593 | 77180 | 63400139 |
| Haemophagocytic lymphohistiocytosis | 127.17 | 22.95 | 54 | 11649 | 10573 | 63466746 |
| Transplant rejection | 126.43 | 22.95 | 54 | 11649 | 10726 | 63466593 |
| Cystitis haemorrhagic | 123.34 | 22.95 | 41 | 11662 | 4082 | 63473237 |
| Cytomegalovirus test positive | 123.13 | 22.95 | 38 | 11665 | 2980 | 63474339 |
| Cytomegalovirus colitis | 114.51 | 22.95 | 34 | 11669 | 2338 | 63474981 |
| Fatigue | 104.68 | 22.95 | 19 | 11684 | 888009 | 62589310 |
| Product use in unapproved indication | 103.14 | 22.95 | 145 | 11558 | 178935 | 63298384 |
| Acute graft versus host disease | 101.19 | 22.95 | 36 | 11667 | 4392 | 63472927 |
| Cytomegalovirus chorioretinitis | 101.12 | 22.95 | 29 | 11674 | 1764 | 63475555 |
| Pneumocystis jirovecii pneumonia | 97.55 | 22.95 | 52 | 11651 | 16862 | 63460457 |
| Epstein-Barr virus associated lymphoproliferative disorder | 95.15 | 22.95 | 28 | 11675 | 1866 | 63475453 |
| Pain | 91.28 | 22.95 | 14 | 11689 | 740614 | 62736705 |
| Haemorrhage intracranial | 88.10 | 22.95 | 45 | 11658 | 13374 | 63463945 |
| Renal failure | 84.19 | 22.95 | 106 | 11597 | 117546 | 63359773 |
| Sepsis | 77.93 | 22.95 | 117 | 11586 | 153006 | 63324313 |
| Septic shock | 74.98 | 22.95 | 76 | 11627 | 66553 | 63410766 |
| Bronchopulmonary aspergillosis | 74.81 | 22.95 | 35 | 11668 | 8600 | 63468719 |
| Renal impairment | 73.60 | 22.95 | 86 | 11617 | 88269 | 63389050 |
| Transplant dysfunction | 72.70 | 22.95 | 29 | 11674 | 4843 | 63472476 |
| Aspergillus infection | 70.72 | 22.95 | 33 | 11670 | 8060 | 63469259 |
| Adenovirus infection | 70.27 | 22.95 | 26 | 11677 | 3545 | 63473774 |
| Graft versus host disease in gastrointestinal tract | 68.97 | 22.95 | 25 | 11678 | 3216 | 63474103 |
| Acute graft versus host disease in skin | 67.44 | 22.95 | 25 | 11678 | 3427 | 63473892 |
| Bone marrow failure | 66.77 | 22.95 | 50 | 11653 | 29240 | 63448079 |
| Thrombotic microangiopathy | 65.24 | 22.95 | 34 | 11669 | 10527 | 63466792 |
| Arthralgia | 65.22 | 22.95 | 13 | 11690 | 569697 | 62907622 |
| Respiratory failure | 62.32 | 22.95 | 85 | 11618 | 101773 | 63375546 |
| Epstein-Barr virus infection reactivation | 59.19 | 22.95 | 16 | 11687 | 782 | 63476537 |
| Kidney transplant rejection | 58.82 | 22.95 | 24 | 11679 | 4247 | 63473072 |
| Posterior reversible encephalopathy syndrome | 56.85 | 22.95 | 37 | 11666 | 17308 | 63460011 |
| Dyspnoea | 56.12 | 22.95 | 26 | 11677 | 661287 | 62816032 |
| Mucormycosis | 53.19 | 22.95 | 20 | 11683 | 2851 | 63474468 |
| Graft versus host disease in skin | 52.96 | 22.95 | 20 | 11683 | 2885 | 63474434 |
| Cytomegalovirus gastrointestinal infection | 52.23 | 22.95 | 12 | 11691 | 298 | 63477021 |
| Cytomegalovirus enterocolitis | 52.13 | 22.95 | 14 | 11689 | 667 | 63476652 |
| BK virus infection | 50.61 | 22.95 | 20 | 11683 | 3259 | 63474060 |
| Viral haemorrhagic cystitis | 48.76 | 22.95 | 14 | 11689 | 855 | 63476464 |
| Cytomegalovirus oesophagitis | 48.52 | 22.95 | 11 | 11692 | 257 | 63477062 |
| Alopecia | 47.39 | 22.95 | 4 | 11699 | 337532 | 63139787 |
| Agranulocytosis | 46.65 | 22.95 | 38 | 11665 | 25096 | 63452223 |
| Nausea | 46.16 | 22.95 | 54 | 11649 | 854417 | 62622902 |
| Gastric ulcer | 46.00 | 22.95 | 37 | 11666 | 24000 | 63453319 |
| Polyomavirus-associated nephropathy | 45.94 | 22.95 | 16 | 11687 | 1832 | 63475487 |
| Parvovirus B19 infection | 45.22 | 22.95 | 12 | 11691 | 546 | 63476773 |
| Chronic graft versus host disease | 44.67 | 22.95 | 18 | 11685 | 3084 | 63474235 |
| Immune reconstitution inflammatory syndrome | 44.62 | 22.95 | 22 | 11681 | 6062 | 63471257 |
| Abdominal discomfort | 44.50 | 22.95 | 4 | 11699 | 320881 | 63156438 |
| Thrombocytopenia | 43.56 | 22.95 | 90 | 11613 | 151067 | 63326252 |
| Lung transplant rejection | 43.49 | 22.95 | 13 | 11690 | 914 | 63476405 |
| Ureaplasma infection | 43.39 | 22.95 | 12 | 11691 | 639 | 63476680 |
| Hepatic function abnormal | 42.91 | 22.95 | 43 | 11660 | 37099 | 63440220 |
| Headache | 42.34 | 22.95 | 33 | 11670 | 633208 | 62844111 |
| Cytomegalovirus gastritis | 40.93 | 22.95 | 9 | 11694 | 182 | 63477137 |
| Product use issue | 40.36 | 22.95 | 110 | 11593 | 220410 | 63256909 |
| Pyrexia | 40.03 | 22.95 | 182 | 11521 | 470296 | 63007023 |
| Pulmonary haemorrhage | 38.39 | 22.95 | 21 | 11682 | 7160 | 63470159 |
| Epstein-Barr viraemia | 38.18 | 22.95 | 12 | 11691 | 998 | 63476321 |
| Myelosuppression | 38.13 | 22.95 | 33 | 11670 | 23670 | 63453649 |
| Complications of transplanted kidney | 37.79 | 22.95 | 15 | 11688 | 2471 | 63474848 |
| Swelling | 36.69 | 22.95 | 4 | 11699 | 275374 | 63201945 |
| Brain oedema | 36.34 | 22.95 | 26 | 11677 | 14169 | 63463150 |
| Hyperammonaemia | 35.66 | 22.95 | 18 | 11685 | 5214 | 63472105 |
| Aplasia pure red cell | 35.23 | 22.95 | 17 | 11686 | 4470 | 63472849 |
| Acute respiratory distress syndrome | 34.33 | 22.95 | 31 | 11672 | 23503 | 63453816 |
| Enterococcal infection | 33.99 | 22.95 | 20 | 11683 | 7828 | 63469491 |
| Dizziness | 33.27 | 22.95 | 19 | 11684 | 429906 | 63047413 |
| Transplant failure | 32.88 | 22.95 | 12 | 11691 | 1573 | 63475746 |
| Hydrocephalus | 32.55 | 22.95 | 17 | 11686 | 5283 | 63472036 |
| Hyperlactacidaemia | 32.50 | 22.95 | 14 | 11689 | 2835 | 63474484 |
| Klebsiella infection | 32.37 | 22.95 | 20 | 11683 | 8546 | 63468773 |
| Pseudomonas infection | 32.11 | 22.95 | 22 | 11681 | 11191 | 63466128 |
| Drug hypersensitivity | 31.71 | 22.95 | 9 | 11694 | 310678 | 63166641 |
| Fungal sepsis | 31.59 | 22.95 | 11 | 11692 | 1259 | 63476060 |
| Pain in extremity | 31.35 | 22.95 | 11 | 11692 | 331475 | 63145844 |
| Confabulation | 31.34 | 22.95 | 8 | 11695 | 312 | 63477007 |
| Venoocclusive liver disease | 31.11 | 22.95 | 16 | 11687 | 4819 | 63472500 |
| Bacterial sepsis | 31.09 | 22.95 | 15 | 11688 | 3943 | 63473376 |
| Pruritus | 30.91 | 22.95 | 14 | 11689 | 361439 | 63115880 |
| Hypogammaglobulinaemia | 30.38 | 22.95 | 18 | 11685 | 7137 | 63470182 |
| Liver transplant rejection | 30.28 | 22.95 | 11 | 11692 | 1424 | 63475895 |
| Cytomegalovirus nephritis | 30.16 | 22.95 | 5 | 11698 | 19 | 63477300 |
| Leukoencephalopathy | 29.54 | 22.95 | 15 | 11688 | 4398 | 63472921 |
| Hypersensitivity | 28.92 | 22.95 | 9 | 11694 | 292676 | 63184643 |
| Renal transplant failure | 28.58 | 22.95 | 9 | 11694 | 753 | 63476566 |
| Lymphopenia | 28.44 | 22.95 | 25 | 11678 | 18302 | 63459017 |
| Staphylococcal sepsis | 28.26 | 22.95 | 18 | 11685 | 8110 | 63469209 |
| Acute graft versus host disease in intestine | 28.16 | 22.95 | 11 | 11692 | 1738 | 63475581 |
| Intentional product use issue | 27.69 | 22.95 | 68 | 11635 | 127824 | 63349495 |
| Product dose omission issue | 27.47 | 22.95 | 5 | 11698 | 234308 | 63243011 |
| Hyphaema | 26.97 | 22.95 | 7 | 11696 | 292 | 63477027 |
| Encephalitis Japanese B | 26.39 | 22.95 | 5 | 11698 | 46 | 63477273 |
| Central nervous system necrosis | 26.27 | 22.95 | 6 | 11697 | 145 | 63477174 |
| Immunosuppressant drug level increased | 26.22 | 22.95 | 13 | 11690 | 3625 | 63473694 |
| Ataxia | 26.16 | 22.95 | 22 | 11681 | 15173 | 63462146 |
| Malaise | 26.10 | 22.95 | 23 | 11680 | 415931 | 63061388 |
| Weight increased | 25.80 | 22.95 | 8 | 11695 | 260784 | 63216535 |
| Human herpesvirus 6 infection | 25.65 | 22.95 | 12 | 11691 | 2945 | 63474374 |
| Fall | 25.46 | 22.95 | 21 | 11682 | 392313 | 63085006 |
| Red blood cells urine positive | 25.02 | 22.95 | 12 | 11691 | 3114 | 63474205 |
| Incision site pain | 24.89 | 22.95 | 9 | 11694 | 1149 | 63476170 |
| Systemic mycosis | 24.60 | 22.95 | 9 | 11694 | 1188 | 63476131 |
| Disseminated cryptococcosis | 24.37 | 22.95 | 7 | 11696 | 428 | 63476891 |
| Apraxia | 24.28 | 22.95 | 10 | 11693 | 1811 | 63475508 |
| Renal tubular necrosis | 24.26 | 22.95 | 19 | 11684 | 11859 | 63465460 |
| Strongyloidiasis | 24.23 | 22.95 | 9 | 11694 | 1239 | 63476080 |
| Leukaemia recurrent | 23.62 | 22.95 | 9 | 11694 | 1329 | 63475990 |
| Gait disturbance | 23.54 | 22.95 | 3 | 11700 | 183175 | 63294144 |
| Cholestasis | 23.40 | 22.95 | 28 | 11675 | 29406 | 63447913 |
| Cytomegalovirus syndrome | 23.40 | 22.95 | 5 | 11698 | 88 | 63477231 |
| Viral load increased | 23.39 | 22.95 | 9 | 11694 | 1365 | 63475954 |
| Colitis | 23.10 | 22.95 | 36 | 11667 | 48492 | 63428827 |
| Genital lesion | 23.05 | 22.95 | 6 | 11697 | 253 | 63477066 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cytomegalovirus infection | 731.63 | 19.11 | 322 | 16824 | 25813 | 34913972 |
| Drug resistance | 527.03 | 19.11 | 256 | 16890 | 25671 | 34914114 |
| Cytomegalovirus viraemia | 389.66 | 19.11 | 144 | 17002 | 7286 | 34932499 |
| Pathogen resistance | 348.67 | 19.11 | 142 | 17004 | 9340 | 34930445 |
| Pneumonia cytomegaloviral | 231.97 | 19.11 | 78 | 17068 | 2976 | 34936809 |
| Cytomegalovirus infection reactivation | 185.85 | 19.11 | 76 | 17070 | 5042 | 34934743 |
| Pancytopenia | 174.93 | 19.11 | 224 | 16922 | 94933 | 34844852 |
| End stage renal disease | 169.30 | 19.11 | 84 | 17062 | 8777 | 34931008 |
| Leukopenia | 158.55 | 19.11 | 174 | 16972 | 62682 | 34877103 |
| Graft versus host disease | 149.77 | 19.11 | 82 | 17064 | 10487 | 34929298 |
| Transplant rejection | 146.12 | 19.11 | 80 | 17066 | 10231 | 34929554 |
| Aspergillus infection | 143.72 | 19.11 | 84 | 17062 | 12170 | 34927615 |
| Product use in unapproved indication | 142.66 | 19.11 | 227 | 16919 | 117272 | 34822513 |
| Pneumocystis jirovecii pneumonia | 138.88 | 19.11 | 98 | 17048 | 19612 | 34920173 |
| Cytomegalovirus test positive | 138.68 | 19.11 | 57 | 17089 | 3829 | 34935956 |
| Multiple organ dysfunction syndrome | 130.89 | 19.11 | 174 | 16972 | 76392 | 34863393 |
| Thrombotic microangiopathy | 127.66 | 19.11 | 74 | 17072 | 10556 | 34929229 |
| Cystitis haemorrhagic | 117.93 | 19.11 | 57 | 17089 | 5622 | 34934163 |
| Encephalitis cytomegalovirus | 117.43 | 19.11 | 32 | 17114 | 586 | 34939199 |
| Cytomegalovirus colitis | 117.21 | 19.11 | 46 | 17100 | 2738 | 34937047 |
| Off label use | 113.67 | 19.11 | 455 | 16691 | 419069 | 34520716 |
| Bone marrow failure | 112.63 | 19.11 | 102 | 17044 | 29151 | 34910634 |
| Drug ineffective | 111.74 | 19.11 | 480 | 16666 | 456271 | 34483514 |
| Respiratory failure | 110.64 | 19.11 | 194 | 16952 | 108378 | 34831407 |
| Fatigue | 105.95 | 19.11 | 26 | 17120 | 370627 | 34569158 |
| Cytomegalovirus chorioretinitis | 105.92 | 19.11 | 46 | 17100 | 3543 | 34936242 |
| Acute graft versus host disease | 104.88 | 19.11 | 55 | 17091 | 6448 | 34933337 |
| Post transplant lymphoproliferative disorder | 93.44 | 19.11 | 51 | 17095 | 6477 | 34933308 |
| Neutropenia | 81.45 | 19.11 | 213 | 16933 | 156565 | 34783220 |
| Nephropathy toxic | 80.43 | 19.11 | 59 | 17087 | 12529 | 34927256 |
| Myelosuppression | 79.74 | 19.11 | 70 | 17076 | 19195 | 34920590 |
| BK virus infection | 77.10 | 19.11 | 43 | 17103 | 5695 | 34934090 |
| Kidney transplant rejection | 73.95 | 19.11 | 46 | 17100 | 7451 | 34932334 |
| Fall | 71.59 | 19.11 | 8 | 17138 | 202877 | 34736908 |
| Dizziness | 71.41 | 19.11 | 11 | 17135 | 218510 | 34721275 |
| Incision site pain | 69.13 | 19.11 | 28 | 17118 | 1810 | 34937975 |
| Haemophagocytic lymphohistiocytosis | 67.91 | 19.11 | 54 | 17092 | 12919 | 34926866 |
| Chronic graft versus host disease | 67.71 | 19.11 | 36 | 17110 | 4337 | 34935448 |
| Glomerulosclerosis | 66.12 | 19.11 | 22 | 17124 | 811 | 34938974 |
| Parvovirus B19 infection | 65.55 | 19.11 | 22 | 17124 | 833 | 34938952 |
| Renal impairment | 63.59 | 19.11 | 142 | 17004 | 94371 | 34845414 |
| Acute graft versus host disease in skin | 61.88 | 19.11 | 36 | 17110 | 5165 | 34934620 |
| Acute graft versus host disease in intestine | 61.77 | 19.11 | 29 | 17117 | 2679 | 34937106 |
| Klebsiella infection | 61.41 | 19.11 | 43 | 17103 | 8488 | 34931297 |
| Product use issue | 60.48 | 19.11 | 110 | 17036 | 63106 | 34876679 |
| Immune reconstitution inflammatory syndrome | 60.39 | 19.11 | 43 | 17103 | 8716 | 34931069 |
| Encephalitis | 57.86 | 19.11 | 39 | 17107 | 7238 | 34932547 |
| Human herpesvirus 8 infection | 55.16 | 19.11 | 20 | 17126 | 955 | 34938830 |
| Drug ineffective for unapproved indication | 55.14 | 19.11 | 63 | 17083 | 23652 | 34916133 |
| Neutrophil Pelger-Huet anomaly present | 52.18 | 19.11 | 14 | 17132 | 241 | 34939544 |
| Cytomegalovirus syndrome | 52.18 | 19.11 | 12 | 17134 | 105 | 34939680 |
| Epstein-Barr virus infection | 51.56 | 19.11 | 37 | 17109 | 7591 | 34932194 |
| Adenovirus infection | 51.20 | 19.11 | 32 | 17114 | 5225 | 34934560 |
| Asthenia | 50.28 | 19.11 | 29 | 17117 | 245222 | 34694563 |
| Aplastic anaemia | 49.90 | 19.11 | 40 | 17106 | 9676 | 34930109 |
| Septic shock | 49.49 | 19.11 | 109 | 17037 | 71725 | 34868060 |
| Graft versus host disease in skin | 48.91 | 19.11 | 28 | 17118 | 3897 | 34935888 |
| Death | 47.95 | 19.11 | 76 | 17070 | 397973 | 34541812 |
| Product dose omission issue | 46.89 | 19.11 | 3 | 17143 | 119708 | 34820077 |
| Pneumocystis jirovecii infection | 46.78 | 19.11 | 21 | 17125 | 1749 | 34938036 |
| Necrotising retinitis | 46.62 | 19.11 | 17 | 17129 | 825 | 34938960 |
| Candida infection | 46.24 | 19.11 | 50 | 17096 | 17665 | 34922120 |
| Epstein-Barr viraemia | 45.97 | 19.11 | 19 | 17127 | 1293 | 34938492 |
| Viral load increased | 45.43 | 19.11 | 23 | 17123 | 2504 | 34937281 |
| Pain | 45.17 | 19.11 | 22 | 17124 | 204653 | 34735132 |
| Bronchopulmonary aspergillosis | 44.76 | 19.11 | 45 | 17101 | 14614 | 34925171 |
| Acanthamoeba infection | 41.12 | 19.11 | 13 | 17133 | 406 | 34939379 |
| Aplasia pure red cell | 39.75 | 19.11 | 29 | 17117 | 6103 | 34933682 |
| Arthralgia | 39.49 | 19.11 | 17 | 17129 | 170024 | 34769761 |
| Lymphocyte count decreased | 39.47 | 19.11 | 52 | 17094 | 22570 | 34917215 |
| Enterococcal infection | 38.86 | 19.11 | 34 | 17112 | 9272 | 34930513 |
| Cytomegalovirus oesophagitis | 38.71 | 19.11 | 13 | 17133 | 493 | 34939292 |
| Macular fibrosis | 38.29 | 19.11 | 12 | 17134 | 364 | 34939421 |
| Botulism | 37.90 | 19.11 | 10 | 17136 | 161 | 34939624 |
| Dyspnoea | 36.49 | 19.11 | 82 | 17064 | 376700 | 34563085 |
| Retinal scar | 35.98 | 19.11 | 11 | 17135 | 307 | 34939478 |
| Pseudomonas infection | 35.96 | 19.11 | 37 | 17109 | 12345 | 34927440 |
| Epstein-Barr virus associated lymphoproliferative disorder | 35.67 | 19.11 | 18 | 17128 | 1946 | 34937839 |
| Brain herniation | 35.55 | 19.11 | 23 | 17123 | 3985 | 34935800 |
| Thrombocytopenia | 35.36 | 19.11 | 161 | 16985 | 156086 | 34783699 |
| Anxiety | 34.82 | 19.11 | 4 | 17142 | 99424 | 34840361 |
| Cytomegalovirus gastritis | 34.18 | 19.11 | 10 | 17136 | 239 | 34939546 |
| Red blood cells urine positive | 34.09 | 19.11 | 17 | 17129 | 1792 | 34937993 |
| Nausea | 33.69 | 19.11 | 73 | 17073 | 339835 | 34599950 |
| Cytomegalovirus enterocolitis | 33.50 | 19.11 | 14 | 17132 | 980 | 34938805 |
| Myocardial infarction | 33.48 | 19.11 | 9 | 17137 | 121076 | 34818709 |
| Pruritus | 33.27 | 19.11 | 14 | 17132 | 141967 | 34797818 |
| Headache | 32.91 | 19.11 | 30 | 17116 | 200605 | 34739180 |
| Pyrexia | 32.50 | 19.11 | 276 | 16870 | 332737 | 34607048 |
| Graft versus host disease in gastrointestinal tract | 32.33 | 19.11 | 21 | 17125 | 3662 | 34936123 |
| Epstein-Barr virus infection reactivation | 32.08 | 19.11 | 14 | 17132 | 1090 | 34938695 |
| Pneumonia bacterial | 31.84 | 19.11 | 34 | 17112 | 11838 | 34927947 |
| Retinal detachment | 31.59 | 19.11 | 24 | 17122 | 5367 | 34934418 |
| Malaise | 31.42 | 19.11 | 27 | 17119 | 185798 | 34753987 |
| Gait disturbance | 30.90 | 19.11 | 3 | 17143 | 85137 | 34854648 |
| Lymphopenia | 30.76 | 19.11 | 39 | 17107 | 16296 | 34923489 |
| Kidney fibrosis | 30.76 | 19.11 | 17 | 17129 | 2211 | 34937574 |
| Cytomegalovirus gastrointestinal infection | 30.49 | 19.11 | 9 | 17137 | 222 | 34939563 |
| Renal tubular disorder | 30.19 | 19.11 | 22 | 17124 | 4621 | 34935164 |
| Toxoplasmosis | 29.73 | 19.11 | 14 | 17132 | 1302 | 34938483 |
| Retinitis | 29.46 | 19.11 | 10 | 17136 | 392 | 34939393 |
| Pneumonia pseudomonal | 28.76 | 19.11 | 20 | 17126 | 3902 | 34935883 |
| Back pain | 28.54 | 19.11 | 12 | 17134 | 121777 | 34818008 |
| Acute respiratory distress syndrome | 28.45 | 19.11 | 48 | 17098 | 25921 | 34913864 |
| Scedosporium infection | 28.31 | 19.11 | 12 | 17134 | 870 | 34938915 |
| Large intestinal ulcer | 27.12 | 19.11 | 15 | 17131 | 1954 | 34937831 |
| Hyperhidrosis | 26.61 | 19.11 | 3 | 17143 | 75689 | 34864096 |
| Cytopenia | 26.57 | 19.11 | 32 | 17114 | 12691 | 34927094 |
| Adenoviral hepatitis | 26.51 | 19.11 | 10 | 17136 | 534 | 34939251 |
| Glomerulonephropathy | 26.42 | 19.11 | 8 | 17138 | 216 | 34939569 |
| Disseminated cytomegaloviral infection | 26.35 | 19.11 | 8 | 17138 | 218 | 34939567 |
| Pain in extremity | 25.82 | 19.11 | 15 | 17131 | 126498 | 34813287 |
| Red blood cell schistocytes present | 25.71 | 19.11 | 8 | 17138 | 237 | 34939548 |
| Meningoencephalitis herpetic | 25.61 | 19.11 | 11 | 17135 | 824 | 34938961 |
| Oesophagopleural fistula | 25.55 | 19.11 | 6 | 17140 | 58 | 34939727 |
| Blood pressure increased | 25.41 | 19.11 | 6 | 17140 | 88096 | 34851689 |
| Fungal sepsis | 25.25 | 19.11 | 11 | 17135 | 853 | 34938932 |
| Infection reactivation | 25.09 | 19.11 | 13 | 17133 | 1485 | 34938300 |
| Intentional product use issue | 24.79 | 19.11 | 75 | 17071 | 59741 | 34880044 |
| Respiratory distress | 24.40 | 19.11 | 54 | 17092 | 35611 | 34904174 |
| Pharyngeal abscess | 24.33 | 19.11 | 9 | 17137 | 455 | 34939330 |
| Septic embolus | 24.17 | 19.11 | 12 | 17134 | 1253 | 34938532 |
| Urinary bladder toxicity | 24.16 | 19.11 | 5 | 17141 | 25 | 34939760 |
| Urinary tract inflammation | 23.86 | 19.11 | 7 | 17139 | 169 | 34939616 |
| Flavobacterium infection | 23.79 | 19.11 | 6 | 17140 | 80 | 34939705 |
| Sepsis | 23.59 | 19.11 | 151 | 16995 | 166410 | 34773375 |
| Cytomegalovirus enteritis | 23.55 | 19.11 | 9 | 17137 | 498 | 34939287 |
| Brain compression | 23.55 | 19.11 | 7 | 17139 | 177 | 34939608 |
| Malignant neoplasm progression | 23.49 | 19.11 | 7 | 17139 | 88039 | 34851746 |
| Renal failure | 23.43 | 19.11 | 126 | 17020 | 130431 | 34809354 |
| Cerebral toxoplasmosis | 23.40 | 19.11 | 13 | 17133 | 1708 | 34938077 |
| Immune recovery uveitis | 23.39 | 19.11 | 5 | 17141 | 30 | 34939755 |
| Cardiac failure congestive | 23.37 | 19.11 | 6 | 17140 | 83264 | 34856521 |
| ADAMTS13 activity decreased | 23.20 | 19.11 | 6 | 17140 | 89 | 34939696 |
| Procedural pain | 23.02 | 19.11 | 19 | 17127 | 4787 | 34934998 |
| Scopulariopsis infection | 22.38 | 19.11 | 6 | 17140 | 103 | 34939682 |
| Fungal infection | 22.37 | 19.11 | 33 | 17113 | 15902 | 34923883 |
| Eye infection fungal | 22.26 | 19.11 | 8 | 17138 | 372 | 34939413 |
| Depression | 22.06 | 19.11 | 10 | 17136 | 97088 | 34842697 |
| Acute graft versus host disease in liver | 21.76 | 19.11 | 12 | 17134 | 1554 | 34938231 |
| Chimerism | 21.63 | 19.11 | 7 | 17139 | 236 | 34939549 |
| Protein urine present | 21.63 | 19.11 | 19 | 17127 | 5209 | 34934576 |
| Viral mutation identified | 21.51 | 19.11 | 15 | 17131 | 2939 | 34936846 |
| Syncope | 21.44 | 19.11 | 9 | 17137 | 91442 | 34848343 |
| Lymphadenopathy mediastinal | 21.26 | 19.11 | 14 | 17132 | 2499 | 34937286 |
| Human herpesvirus 6 infection | 21.10 | 19.11 | 13 | 17133 | 2068 | 34937717 |
| Liver transplant rejection | 20.89 | 19.11 | 13 | 17133 | 2106 | 34937679 |
| Cytomegalovirus hepatitis | 20.72 | 19.11 | 8 | 17138 | 455 | 34939330 |
| Constipation | 20.69 | 19.11 | 22 | 17124 | 136960 | 34802825 |
| Bone marrow disorder | 20.61 | 19.11 | 12 | 17134 | 1723 | 34938062 |
| Peripheral swelling | 20.57 | 19.11 | 6 | 17140 | 76535 | 34863250 |
| Weight increased | 20.49 | 19.11 | 10 | 17136 | 93023 | 34846762 |
| Myocarditis toxoplasmal | 20.39 | 19.11 | 5 | 17141 | 59 | 34939726 |
| Bacterial toxaemia | 20.37 | 19.11 | 6 | 17140 | 147 | 34939638 |
| Insomnia | 20.25 | 19.11 | 13 | 17133 | 103894 | 34835891 |
| Polyomavirus-associated nephropathy | 20.11 | 19.11 | 16 | 17130 | 3828 | 34935957 |
| Hepatitis cholestatic | 19.98 | 19.11 | 22 | 17124 | 7925 | 34931860 |
| Cerebral aspergillosis | 19.97 | 19.11 | 11 | 17135 | 1421 | 34938364 |
| Conductive deafness | 19.96 | 19.11 | 7 | 17139 | 303 | 34939482 |
| Clostridium difficile colitis | 19.85 | 19.11 | 31 | 17115 | 15699 | 34924086 |
| Diffuse alveolar damage | 19.84 | 19.11 | 13 | 17133 | 2301 | 34937484 |
| Enterococcal bacteraemia | 19.62 | 19.11 | 12 | 17134 | 1885 | 34937900 |
| Complications of transplanted kidney | 19.57 | 19.11 | 17 | 17129 | 4592 | 34935193 |
| Rash | 19.50 | 19.11 | 51 | 17095 | 222701 | 34717084 |
| Organising pneumonia | 19.44 | 19.11 | 19 | 17127 | 5960 | 34933825 |
| Escherichia sepsis | 19.27 | 19.11 | 17 | 17129 | 4687 | 34935098 |
| Immunosuppressant drug level increased | 19.24 | 19.11 | 19 | 17127 | 6036 | 34933749 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cytomegalovirus infection | 1195.25 | 18.61 | 473 | 26556 | 42171 | 79675188 |
| Drug resistance | 1006.56 | 18.61 | 417 | 26612 | 41796 | 79675563 |
| Pathogen resistance | 647.44 | 18.61 | 226 | 26803 | 14116 | 79703243 |
| Cytomegalovirus viraemia | 628.99 | 18.61 | 215 | 26814 | 12606 | 79704753 |
| Post transplant lymphoproliferative disorder | 358.87 | 18.61 | 138 | 26891 | 11326 | 79706033 |
| Multiple organ dysfunction syndrome | 354.98 | 18.61 | 307 | 26722 | 119939 | 79597420 |
| Pneumonia cytomegaloviral | 339.10 | 18.61 | 107 | 26922 | 4862 | 79712497 |
| Pancytopenia | 331.63 | 18.61 | 341 | 26688 | 165404 | 79551955 |
| Cytomegalovirus infection reactivation | 320.32 | 18.61 | 118 | 26911 | 8598 | 79708761 |
| Encephalitis cytomegalovirus | 314.71 | 18.61 | 74 | 26955 | 1076 | 79716283 |
| Graft versus host disease | 283.62 | 18.61 | 126 | 26903 | 14900 | 79702459 |
| Leukopenia | 274.18 | 18.61 | 262 | 26767 | 116251 | 79601108 |
| Epstein-Barr virus infection | 262.87 | 18.61 | 118 | 26911 | 14298 | 79703061 |
| Transplant rejection | 246.79 | 18.61 | 124 | 26905 | 19313 | 79698046 |
| Off label use | 245.53 | 18.61 | 767 | 26262 | 906448 | 78810911 |
| Cytomegalovirus test positive | 242.70 | 18.61 | 87 | 26942 | 5860 | 79711499 |
| Product use in unapproved indication | 240.71 | 18.61 | 356 | 26673 | 250003 | 79467356 |
| Smooth muscle cell neoplasm | 232.56 | 18.61 | 56 | 26973 | 906 | 79716453 |
| Cystitis haemorrhagic | 222.91 | 18.61 | 92 | 26937 | 9080 | 79708279 |
| Aspergillus infection | 213.63 | 18.61 | 112 | 26917 | 19049 | 79698310 |
| Cytomegalovirus colitis | 211.97 | 18.61 | 74 | 26955 | 4611 | 79712748 |
| Nephropathy toxic | 209.72 | 18.61 | 113 | 26916 | 20306 | 79697053 |
| Fatigue | 198.17 | 18.61 | 38 | 26991 | 929689 | 78787670 |
| Pneumocystis jirovecii pneumonia | 192.29 | 18.61 | 126 | 26903 | 32382 | 79684977 |
| Cytomegalovirus chorioretinitis | 182.25 | 18.61 | 69 | 26960 | 5421 | 79711938 |
| Acute graft versus host disease | 178.29 | 18.61 | 81 | 26948 | 10086 | 79707273 |
| End stage renal disease | 170.07 | 18.61 | 83 | 26946 | 12137 | 79705222 |
| Neutropenia | 169.59 | 18.61 | 329 | 26700 | 287381 | 79429978 |
| Cytomegalovirus syndrome | 169.45 | 18.61 | 35 | 26994 | 266 | 79717093 |
| Bone marrow failure | 168.06 | 18.61 | 139 | 26890 | 50968 | 79666391 |
| Haemophagocytic lymphohistiocytosis | 167.91 | 18.61 | 100 | 26929 | 21737 | 79695622 |
| Thrombotic microangiopathy | 159.36 | 18.61 | 94 | 26935 | 20075 | 79697284 |
| Drug ineffective | 149.94 | 18.61 | 741 | 26288 | 1080172 | 78637187 |
| BK virus infection | 147.65 | 18.61 | 68 | 26961 | 8736 | 79708623 |
| Pain | 145.09 | 18.61 | 31 | 26998 | 703771 | 79013588 |
| Renal impairment | 142.31 | 18.61 | 218 | 26811 | 157565 | 79559794 |
| Respiratory failure | 139.91 | 18.61 | 233 | 26796 | 180678 | 79536681 |
| Arthralgia | 120.21 | 18.61 | 24 | 27005 | 571779 | 79145580 |
| Septic shock | 119.72 | 18.61 | 176 | 26853 | 122625 | 79594734 |
| Kidney transplant rejection | 114.49 | 18.61 | 60 | 26969 | 10186 | 79707173 |
| Adenovirus infection | 110.46 | 18.61 | 55 | 26974 | 8392 | 79708967 |
| Parvovirus B19 infection | 109.87 | 18.61 | 34 | 26995 | 1446 | 79715913 |
| Epstein-Barr virus associated lymphoproliferative disorder | 108.65 | 18.61 | 42 | 26987 | 3490 | 79713869 |
| Graft versus host disease in skin | 105.26 | 18.61 | 48 | 26981 | 6025 | 79711334 |
| Dizziness | 104.74 | 18.61 | 25 | 27004 | 526416 | 79190943 |
| Myelosuppression | 101.10 | 18.61 | 94 | 26935 | 40202 | 79677157 |
| Incision site pain | 99.13 | 18.61 | 37 | 26992 | 2793 | 79714566 |
| Immune reconstitution inflammatory syndrome | 97.67 | 18.61 | 60 | 26969 | 13781 | 79703578 |
| Nausea | 97.41 | 18.61 | 109 | 26920 | 957087 | 78760272 |
| Acute graft versus host disease in skin | 94.67 | 18.61 | 48 | 26981 | 7610 | 79709749 |
| Chronic graft versus host disease | 94.17 | 18.61 | 46 | 26983 | 6735 | 79710624 |
| Dyspnoea | 93.44 | 18.61 | 92 | 26937 | 856933 | 78860426 |
| Fall | 93.43 | 18.61 | 25 | 27004 | 487604 | 79229755 |
| Klebsiella infection | 93.10 | 18.61 | 61 | 26968 | 15659 | 79701700 |
| Epstein-Barr virus infection reactivation | 89.89 | 18.61 | 31 | 26998 | 1861 | 79715498 |
| Graft versus host disease in gastrointestinal tract | 87.92 | 18.61 | 43 | 26986 | 6313 | 79711046 |
| Headache | 87.70 | 18.61 | 57 | 26972 | 653715 | 79063644 |
| Bronchopulmonary aspergillosis | 86.84 | 18.61 | 67 | 26962 | 22227 | 79695132 |
| Epstein-Barr viraemia | 85.25 | 18.61 | 31 | 26998 | 2174 | 79715185 |
| Aplasia pure red cell | 85.17 | 18.61 | 45 | 26984 | 7765 | 79709594 |
| Product use issue | 83.48 | 18.61 | 205 | 26824 | 209617 | 79507742 |
| Renal failure | 82.78 | 18.61 | 199 | 26830 | 200769 | 79516590 |
| Sepsis | 81.70 | 18.61 | 238 | 26791 | 269190 | 79448169 |
| Cytomegalovirus oesophagitis | 80.58 | 18.61 | 23 | 27006 | 737 | 79716622 |
| Cytomegalovirus gastritis | 77.03 | 18.61 | 20 | 27009 | 445 | 79716914 |
| Pruritus | 72.29 | 18.61 | 22 | 27007 | 394626 | 79322733 |
| Enterococcal infection | 72.02 | 18.61 | 52 | 26977 | 15608 | 79701751 |
| Cytomegalovirus enterocolitis | 70.50 | 18.61 | 25 | 27004 | 1630 | 79715729 |
| Necrotising retinitis | 69.39 | 18.61 | 23 | 27006 | 1222 | 79716137 |
| Transplant dysfunction | 68.69 | 18.61 | 38 | 26991 | 7183 | 79710176 |
| Peripheral swelling | 66.53 | 18.61 | 7 | 27022 | 269610 | 79447749 |
| Viral load increased | 66.34 | 18.61 | 28 | 27001 | 2920 | 79714439 |
| Human herpesvirus 8 infection | 65.85 | 18.61 | 22 | 27007 | 1198 | 79716161 |
| Thrombocytopenia | 65.30 | 18.61 | 218 | 26811 | 265041 | 79452318 |
| Malaise | 65.23 | 18.61 | 43 | 26986 | 489826 | 79227533 |
| Viral haemorrhagic cystitis | 65.15 | 18.61 | 25 | 27004 | 2036 | 79715323 |
| Pyrexia | 64.77 | 18.61 | 422 | 26607 | 678287 | 79039072 |
| Drug ineffective for unapproved indication | 64.28 | 18.61 | 83 | 26946 | 51155 | 79666204 |
| Pseudomonas infection | 62.80 | 18.61 | 54 | 26975 | 20849 | 79696510 |
| Product dose omission issue | 62.19 | 18.61 | 6 | 27023 | 247531 | 79469828 |
| Aplastic anaemia | 61.55 | 18.61 | 50 | 26979 | 17855 | 79699504 |
| Lymphopenia | 61.15 | 18.61 | 63 | 26966 | 30494 | 79686865 |
| Cytomegalovirus gastrointestinal infection | 61.12 | 18.61 | 17 | 27012 | 495 | 79716864 |
| Encephalitis | 61.09 | 18.61 | 46 | 26983 | 14714 | 79702645 |
| Acute graft versus host disease in intestine | 60.91 | 18.61 | 29 | 27000 | 4012 | 79713347 |
| Pain in extremity | 60.42 | 18.61 | 24 | 27005 | 364514 | 79352845 |
| Glomerulosclerosis | 59.64 | 18.61 | 20 | 27009 | 1102 | 79716257 |
| Candida infection | 57.77 | 18.61 | 68 | 26961 | 38146 | 79679213 |
| Drug intolerance | 57.72 | 18.61 | 10 | 27019 | 264109 | 79453250 |
| Anxiety | 57.51 | 18.61 | 8 | 27021 | 248504 | 79468855 |
| Polyomavirus-associated nephropathy | 57.36 | 18.61 | 31 | 26998 | 5596 | 79711763 |
| Alopecia | 57.09 | 18.61 | 6 | 27023 | 231349 | 79486010 |
| Abdominal discomfort | 55.88 | 18.61 | 9 | 27020 | 250718 | 79466641 |
| Lymphocyte count decreased | 55.29 | 18.61 | 74 | 26955 | 47215 | 79670144 |
| Red blood cells urine positive | 55.27 | 18.61 | 29 | 27000 | 4934 | 79712425 |
| Asthenia | 54.39 | 18.61 | 56 | 26973 | 511633 | 79205726 |
| Liver transplant rejection | 54.18 | 18.61 | 25 | 27004 | 3223 | 79714136 |
| Back pain | 53.82 | 18.61 | 18 | 27011 | 304162 | 79413197 |
| Complications of transplanted kidney | 53.79 | 18.61 | 31 | 26998 | 6335 | 79711024 |
| Mucormycosis | 52.93 | 18.61 | 34 | 26995 | 8435 | 79708924 |
| Hypogammaglobulinaemia | 52.80 | 18.61 | 40 | 26989 | 12911 | 79704448 |
| Neutrophil Pelger-Huet anomaly present | 52.26 | 18.61 | 14 | 27015 | 353 | 79717006 |
| Acute respiratory distress syndrome | 51.58 | 18.61 | 69 | 26960 | 43998 | 79673361 |
| Vomiting | 50.56 | 18.61 | 93 | 26936 | 665735 | 79051624 |
| Swelling | 50.08 | 18.61 | 7 | 27022 | 216704 | 79500655 |
| Weight increased | 49.80 | 18.61 | 16 | 27013 | 277370 | 79439989 |
| Gait disturbance | 49.64 | 18.61 | 6 | 27023 | 207500 | 79509859 |
| Brain herniation | 49.23 | 18.61 | 31 | 26998 | 7432 | 79709927 |
| Immunosuppressant drug level increased | 48.56 | 18.61 | 33 | 26996 | 8994 | 79708365 |
| Acanthamoeba infection | 47.83 | 18.61 | 14 | 27015 | 491 | 79716868 |
| Respiratory distress | 47.51 | 18.61 | 77 | 26952 | 58262 | 79659097 |
| Pneumocystis jirovecii infection | 47.42 | 18.61 | 22 | 27007 | 2872 | 79714487 |
| Nasopharyngitis | 46.73 | 18.61 | 14 | 27015 | 253867 | 79463492 |
| Blood pressure increased | 46.18 | 18.61 | 8 | 27021 | 211352 | 79506007 |
| Drug hypersensitivity | 45.83 | 18.61 | 22 | 27007 | 298894 | 79418465 |
| Haemorrhage intracranial | 45.33 | 18.61 | 50 | 26979 | 26143 | 79691216 |
| Cytomegalovirus enteritis | 45.22 | 18.61 | 15 | 27014 | 799 | 79716560 |
| Muscle spasms | 44.50 | 18.61 | 4 | 27025 | 174726 | 79542633 |
| Hepatic function abnormal | 43.39 | 18.61 | 84 | 26945 | 73023 | 79644336 |
| Urticaria | 42.75 | 18.61 | 6 | 27023 | 185195 | 79532164 |
| Pneumonia pseudomonal | 42.66 | 18.61 | 26 | 27003 | 5885 | 79711474 |
| Cytopenia | 42.56 | 18.61 | 43 | 26986 | 20340 | 79697019 |
| Intentional product use issue | 41.90 | 18.61 | 130 | 26899 | 151982 | 79565377 |
| Bacterial sepsis | 41.81 | 18.61 | 29 | 27000 | 8169 | 79709190 |
| Cytomegalovirus hepatitis | 41.77 | 18.61 | 14 | 27015 | 770 | 79716589 |
| Therapeutic product effect decreased | 41.07 | 18.61 | 4 | 27025 | 163859 | 79553500 |
| Retinal detachment | 40.91 | 18.61 | 30 | 26999 | 9217 | 79708142 |
| Rash | 40.23 | 18.61 | 85 | 26944 | 578273 | 79139086 |
| Pulmonary haemorrhage | 40.16 | 18.61 | 36 | 26993 | 14681 | 79702678 |
| Scedosporium infection | 39.93 | 18.61 | 16 | 27013 | 1462 | 79715897 |
| Human herpesvirus 6 infection | 39.73 | 18.61 | 24 | 27005 | 5346 | 79712013 |
| Lung transplant rejection | 39.38 | 18.61 | 16 | 27013 | 1515 | 79715844 |
| Hypersensitivity | 39.14 | 18.61 | 20 | 27009 | 262219 | 79455140 |
| Contusion | 39.00 | 18.61 | 3 | 27026 | 148773 | 79568586 |
| Pneumonia bacterial | 38.94 | 18.61 | 40 | 26989 | 19291 | 79698068 |
| Strongyloidiasis | 38.41 | 18.61 | 21 | 27008 | 3877 | 79713482 |
| Gastric ulcer | 38.02 | 18.61 | 52 | 26977 | 33853 | 79683506 |
| Ureaplasma infection | 37.77 | 18.61 | 14 | 27015 | 1036 | 79716323 |
| Insomnia | 37.64 | 18.61 | 18 | 27011 | 245152 | 79472207 |
| Musculoskeletal stiffness | 37.41 | 18.61 | 7 | 27022 | 175001 | 79542358 |
| Fungal sepsis | 36.63 | 18.61 | 16 | 27013 | 1814 | 79715545 |
| Toxoplasmosis | 36.56 | 18.61 | 18 | 27011 | 2679 | 79714680 |
| Viral mutation identified | 35.86 | 18.61 | 20 | 27009 | 3838 | 79713521 |
| Cerebral toxoplasmosis | 35.75 | 18.61 | 17 | 27012 | 2345 | 79715014 |
| Disseminated cytomegaloviral infection | 35.63 | 18.61 | 11 | 27018 | 464 | 79716895 |
| Posterior reversible encephalopathy syndrome | 35.21 | 18.61 | 44 | 26985 | 26237 | 79691122 |
| Abdominal pain upper | 35.03 | 18.61 | 16 | 27013 | 223803 | 79493556 |
| Macular fibrosis | 34.94 | 18.61 | 12 | 27017 | 711 | 79716648 |
| Hyperhidrosis | 34.74 | 18.61 | 5 | 27024 | 151487 | 79565872 |
| Protein urine present | 34.25 | 18.61 | 28 | 27001 | 10084 | 79707275 |
| Myocardial infarction | 34.15 | 18.61 | 10 | 27019 | 184119 | 79533240 |
| Fungal infection | 33.85 | 18.61 | 55 | 26974 | 41693 | 79675666 |
| Sinusitis | 33.81 | 18.61 | 12 | 27017 | 195489 | 79521870 |
| Infusion related reaction | 33.70 | 18.61 | 18 | 27011 | 230219 | 79487140 |
| Botulism | 33.37 | 18.61 | 10 | 27019 | 381 | 79716978 |
| Renal tubular disorder | 33.21 | 18.61 | 23 | 27006 | 6463 | 79710896 |
| Injection site pain | 32.98 | 18.61 | 3 | 27026 | 129835 | 79587524 |
| Disseminated intravascular coagulation | 32.92 | 18.61 | 50 | 26979 | 35792 | 79681567 |
| Lower respiratory tract infection | 32.79 | 18.61 | 3 | 27026 | 129217 | 79588142 |
| Retinal scar | 32.48 | 18.61 | 10 | 27019 | 418 | 79716941 |
| Hepatic failure | 32.33 | 18.61 | 67 | 26962 | 61145 | 79656214 |
| Contraindicated product administered | 32.21 | 18.61 | 7 | 27022 | 157531 | 79559828 |
| Asthma | 32.07 | 18.61 | 4 | 27025 | 135091 | 79582268 |
| Kidney fibrosis | 31.98 | 18.61 | 18 | 27011 | 3517 | 79713842 |
| Macular oedema | 31.82 | 18.61 | 21 | 27008 | 5453 | 79711906 |
| Death | 31.78 | 18.61 | 93 | 26936 | 566421 | 79150938 |
| Somnolence | 31.72 | 18.61 | 21 | 27008 | 238960 | 79478399 |
| Depression | 31.66 | 18.61 | 17 | 27012 | 216773 | 79500586 |
| Complications of transplanted lung | 31.47 | 18.61 | 10 | 27019 | 464 | 79716895 |
| Neutrophil count increased | 31.34 | 18.61 | 44 | 26985 | 29352 | 79688007 |
| Constipation | 31.14 | 18.61 | 30 | 26999 | 283020 | 79434339 |
| Syncope | 31.06 | 18.61 | 11 | 27018 | 179438 | 79537921 |
| Confabulation | 30.99 | 18.61 | 10 | 27019 | 488 | 79716871 |
| Agranulocytosis | 30.80 | 18.61 | 55 | 26974 | 44975 | 79672384 |
| Transplant failure | 29.92 | 18.61 | 19 | 27010 | 4622 | 79712737 |
| Chest pain | 29.82 | 18.61 | 31 | 26998 | 282273 | 79435086 |
| Cardiac failure congestive | 29.79 | 18.61 | 6 | 27023 | 142396 | 79574963 |
| Lymphoproliferative disorder | 28.95 | 18.61 | 20 | 27009 | 5595 | 79711764 |
| Blood urea increased | 28.87 | 18.61 | 56 | 26973 | 48734 | 79668625 |
| Wheezing | 28.83 | 18.61 | 3 | 27026 | 116661 | 79600698 |
| Complications of transplanted liver | 28.51 | 18.61 | 9 | 27020 | 409 | 79716950 |
| Infection reactivation | 28.10 | 18.61 | 15 | 27014 | 2642 | 79714717 |
| Neurological decompensation | 27.77 | 18.61 | 19 | 27010 | 5234 | 79712125 |
| Pleural effusion | 27.73 | 18.61 | 110 | 26919 | 145152 | 79572207 |
| Acinetobacter infection | 27.47 | 18.61 | 15 | 27014 | 2762 | 79714597 |
| Toxic epidermal necrolysis | 27.40 | 18.61 | 52 | 26977 | 44529 | 79672830 |
| Hypoproteinaemia | 27.17 | 18.61 | 17 | 27012 | 4029 | 79713330 |
| Venoocclusive liver disease | 26.73 | 18.61 | 26 | 27003 | 11745 | 79705614 |
| Hepatitis cholestatic | 26.70 | 18.61 | 28 | 27001 | 13824 | 79703535 |
| Glomerulonephropathy | 26.54 | 18.61 | 8 | 27021 | 311 | 79717048 |
| Acute graft versus host disease in liver | 26.49 | 18.61 | 13 | 27016 | 1922 | 79715437 |
| Organising pneumonia | 26.43 | 18.61 | 25 | 27004 | 10914 | 79706445 |
| Squamous cell carcinoma of skin | 26.40 | 18.61 | 28 | 27001 | 14005 | 79703354 |
| Meningoencephalitis herpetic | 26.15 | 18.61 | 13 | 27016 | 1976 | 79715383 |
| Enterococcal bacteraemia | 26.08 | 18.61 | 15 | 27014 | 3053 | 79714306 |
| Cerebrovascular accident | 26.06 | 18.61 | 10 | 27019 | 155282 | 79562077 |
| Urinary bladder toxicity | 26 | 18.61 | 5 | 27024 | 25 | 79717334 |
| Septic embolus | 25.77 | 18.61 | 13 | 27016 | 2038 | 79715321 |
| Escherichia sepsis | 25.59 | 18.61 | 22 | 27007 | 8486 | 79708873 |
| Cytomegalovirus duodenitis | 25.40 | 18.61 | 6 | 27023 | 89 | 79717270 |
| Staphylococcal sepsis | 25.29 | 18.61 | 28 | 27001 | 14698 | 79702661 |
| Systemic mycosis | 25.27 | 18.61 | 14 | 27015 | 2652 | 79714707 |
| Immune recovery uveitis | 25.23 | 18.61 | 5 | 27024 | 30 | 79717329 |
| Flavobacterium infection | 24.92 | 18.61 | 6 | 27023 | 97 | 79717262 |
| Platelet count decreased | 24.90 | 18.61 | 131 | 26898 | 194533 | 79522826 |
| Blood creatinine increased | 24.61 | 18.61 | 111 | 26918 | 154946 | 79562413 |
| Malnutrition | 24.46 | 18.61 | 34 | 26995 | 22468 | 79694891 |
| Conductive deafness | 24.12 | 18.61 | 7 | 27022 | 238 | 79717121 |
| Paraesthesia | 24.07 | 18.61 | 15 | 27014 | 176308 | 79541051 |
| Pharyngeal abscess | 23.96 | 18.61 | 9 | 27020 | 691 | 79716668 |
| Scopulariopsis infection | 23.67 | 18.61 | 6 | 27023 | 121 | 79717238 |
| Hypoaesthesia | 23.47 | 18.61 | 16 | 27013 | 179336 | 79538023 |
| Balance disorder | 23.29 | 18.61 | 3 | 27026 | 98854 | 79618505 |
| Meningitis viral | 23.23 | 18.61 | 12 | 27017 | 1976 | 79715383 |
| Actinic keratosis | 23.18 | 18.61 | 18 | 27011 | 6024 | 79711335 |
| Oliguria | 22.97 | 18.61 | 28 | 27001 | 16281 | 79701078 |
| Chimerism | 22.82 | 18.61 | 7 | 27022 | 289 | 79717070 |
| Oesophagopleural fistula | 22.71 | 18.61 | 5 | 27024 | 53 | 79717306 |
| Eye infection fungal | 22.57 | 18.61 | 8 | 27021 | 521 | 79716838 |
| Focal segmental glomerulosclerosis | 22.42 | 18.61 | 14 | 27015 | 3307 | 79714052 |
| Retinal haemorrhage | 22.22 | 18.61 | 20 | 27009 | 8197 | 79709162 |
| Bacterial toxaemia | 22.18 | 18.61 | 6 | 27023 | 157 | 79717202 |
| Mobility decreased | 21.99 | 18.61 | 7 | 27022 | 122168 | 79595191 |
| Loss of consciousness | 21.95 | 18.61 | 15 | 27014 | 167928 | 79549431 |
| Myocarditis toxoplasmal | 21.85 | 18.61 | 5 | 27024 | 64 | 79717295 |
| Idiopathic pneumonia syndrome | 21.63 | 18.61 | 8 | 27021 | 588 | 79716771 |
| Adenoviral hepatitis | 21.51 | 18.61 | 9 | 27020 | 918 | 79716441 |
| Encephalitis Japanese B | 21.50 | 18.61 | 5 | 27024 | 69 | 79717290 |
| Cerebral aspergillosis | 21.45 | 18.61 | 11 | 27018 | 1785 | 79715574 |
| Diffuse alveolar damage | 21.37 | 18.61 | 14 | 27015 | 3590 | 79713769 |
| Opportunistic infection | 21.35 | 18.61 | 13 | 27016 | 2937 | 79714422 |
| Blister | 21.23 | 18.61 | 7 | 27022 | 119469 | 79597890 |
| ADAMTS13 activity decreased | 21.21 | 18.61 | 6 | 27023 | 186 | 79717173 |
| Rhegmatogenous retinal detachment | 21.09 | 18.61 | 6 | 27023 | 190 | 79717169 |
| Renal transplant failure | 20.83 | 18.61 | 11 | 27018 | 1896 | 79715463 |
| Human herpesvirus 6 encephalitis | 20.63 | 18.61 | 8 | 27021 | 670 | 79716689 |
| Clostridium difficile colitis | 20.26 | 18.61 | 38 | 26991 | 32245 | 79685114 |
| Engraft failure | 20.24 | 18.61 | 8 | 27021 | 705 | 79716654 |
| Tractional retinal detachment | 20.21 | 18.61 | 5 | 27024 | 91 | 79717268 |
| Hyperlactacidaemia | 20.02 | 18.61 | 16 | 27013 | 5579 | 79711780 |
| Hypoalbuminaemia | 19.97 | 18.61 | 30 | 26999 | 21267 | 79696092 |
| Heart rate increased | 19.88 | 18.61 | 8 | 27021 | 120716 | 79596643 |
| Palpitations | 19.88 | 18.61 | 9 | 27020 | 126601 | 79590758 |
| Migraine | 19.80 | 18.61 | 3 | 27026 | 87490 | 79629869 |
| Epstein-Barr virus test positive | 19.73 | 18.61 | 9 | 27020 | 1130 | 79716229 |
| Varicella zoster oesophagitis | 19.65 | 18.61 | 4 | 27025 | 28 | 79717331 |
| Hospitalisation | 19.65 | 18.61 | 4 | 27025 | 94232 | 79623127 |
| Urinary tract inflammation | 19.41 | 18.61 | 6 | 27023 | 254 | 79717105 |
| Marrow hyperplasia | 19.41 | 18.61 | 10 | 27019 | 1638 | 79715721 |
| Ascites | 19.34 | 18.61 | 63 | 26966 | 75499 | 79641860 |
| Haematotoxicity | 19.24 | 18.61 | 25 | 27004 | 15494 | 79701865 |
| Tubulointerstitial nephritis | 19.20 | 18.61 | 41 | 26988 | 38194 | 79679165 |
| Viraemia | 19.13 | 18.61 | 12 | 27017 | 2857 | 79714502 |
| Polyomavirus viraemia | 19.08 | 18.61 | 10 | 27019 | 1697 | 79715662 |
| Varicella zoster gastritis | 19.07 | 18.61 | 4 | 27025 | 33 | 79717326 |
| Chronic allograft nephropathy | 19.06 | 18.61 | 10 | 27019 | 1701 | 79715658 |
| Hydrocephalus | 18.99 | 18.61 | 19 | 27010 | 8881 | 79708478 |
| Leukoencephalopathy | 18.92 | 18.61 | 18 | 27011 | 7911 | 79709448 |
| Enteritis | 18.87 | 18.61 | 24 | 27005 | 14559 | 79702800 |
| Lymphadenopathy mediastinal | 18.86 | 18.61 | 14 | 27015 | 4382 | 79712977 |
| Necrotising herpetic retinopathy | 18.82 | 18.61 | 5 | 27024 | 122 | 79717237 |
| Central nervous system necrosis | 18.71 | 18.61 | 6 | 27023 | 287 | 79717072 |
| Colitis | 18.66 | 18.61 | 61 | 26968 | 73246 | 79644113 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J05AB06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleosides and nucleotides excl. reverse transcriptase inhibitors |
| ATC | S01AD09 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antivirals |
| FDA MoA | N0000020060 | DNA Polymerase Inhibitors |
| FDA EXT | N0000175459 | Nucleoside Analog |
| FDA EPC | N0000175461 | Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor |
| FDA EPC | N0000175466 | Nucleoside Analog Antiviral |
| CHEBI has role | CHEBI:35441 | antiinfective agents |
| CHEBI has role | CHEBI:36044 | antiviral drugs |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000998 | Antiviral Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Cytomegaloviral retinitis | indication | 22455005 | |
| Herpes simplex dendritic keratitis | indication | 29943008 | |
| Paroxysmal supraventricular tachycardia | indication | 67198005 | |
| CMV Retinitis in AIDS Patients | indication | ||
| Prevention of CMV Disease After Kidney-Pancreas Transplantation | indication | ||
| CMV Retinitis in Immunocompromised Patients | indication | ||
| Prevention of CMV Disease After Organ Transplant | indication | ||
| Prevention of CMV Disease After Kidney Transplantation | indication | ||
| Myocardial Perfusion Imaging Adjunct | indication | ||
| Prevention of CMV Disease in Advanced HIV Patients | indication | ||
| Prevention of CMV Disease After Cardiac Transplantation | indication | ||
| Supraventricular tachycardia | off-label use | 6456007 | |
| Cytomegalovirus infection | off-label use | 28944009 | |
| CMV-Related Polyradiculopathy in AIDS Patients | off-label use | ||
| Prevention of Cytomegalovirus Disease | off-label use | ||
| Endophthalmitis | contraindication | 1847009 | DOID:4692 |
| Pericarditis | contraindication | 3238004 | DOID:1787 |
| Reduced visual acuity | contraindication | 13164000 | |
| Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
| Disorder of autonomic nervous system | contraindication | 15241006 | |
| Complete atrioventricular block | contraindication | 27885002 | |
| Hypovolemia | contraindication | 28560003 | |
| Acute cerebrovascular insufficiency | contraindication | 29322000 | |
| Vitreous hemorrhage | contraindication | 31341008 | |
| Transplantation of heart | contraindication | 32413006 | |
| Dehydration | contraindication | 34095006 | |
| Sick sinus syndrome | contraindication | 36083008 | DOID:13884 |
| Retinal detachment | contraindication | 42059000 | DOID:5327 |
| Low blood pressure | contraindication | 45007003 | |
| Acute nephropathy | contraindication | 58574008 | |
| Aortic valve stenosis | contraindication | 60573004 | DOID:1712 |
| Left to right cardiovascular shunt | contraindication | 66130006 | |
| Mitral valve stenosis | contraindication | 79619009 | DOID:1754 |
| Pulmonary emphysema | contraindication | 87433001 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Bilateral cataracts | contraindication | 95722004 | |
| Respiratory alkalosis | contraindication | 111378004 | |
| Eye infection | contraindication | 128351009 | |
| Uveitis | contraindication | 128473001 | DOID:13141 |
| Second degree atrioventricular block | contraindication | 195042002 | |
| Asthma | contraindication | 195967001 | DOID:2841 |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
| Aplastic anemia | contraindication | 306058006 | DOID:12449 |
| Left main coronary artery disease | contraindication | 371804009 | |
| Acute coronary syndrome | contraindication | 394659003 | |
| Respiratory insufficiency | contraindication | 409623005 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Granulocytopenic disorder | contraindication | 417672002 | |
| Severe Bone Marrow Depression | contraindication | ||
| Syncope due to Bradycardia | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.97 | acidic |
| pKa2 | 12.38 | acidic |
| pKa3 | 12.98 | acidic |
| pKa4 | 3.68 | Basic |
| pKa5 | 2.12 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 | GPCR | Ki | 6.05 | WOMBAT-PK | |||||
| Metabotropic glutamate receptor 5 | GPCR | Ki | 5.41 | WOMBAT-PK | |||||
| Transitional endoplasmic reticulum ATPase | Enzyme | IC50 | 5.89 | CHEMBL | |||||
| DNA polymerase catalytic subunit | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
| Thymidine kinase | Kinase | WOMBAT-PK | |||||||
| Capsid scaffolding protein | Enzyme | EC50 | 6.07 | WOMBAT-PK | |||||
| Purine nucleoside phosphorylase | Enzyme | Kd | 4.80 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019764 | VUID |
| N0000147855 | NUI |
| D00333 | KEGG_DRUG |
| 107910-75-8 | SECONDARY_CAS_RN |
| 4019457 | VANDF |
| 4019764 | VANDF |
| C0017066 | UMLSCUI |
| CHEBI:465284 | CHEBI |
| GA2 | PDB_CHEM_ID |
| CHEMBL182 | ChEMBL_ID |
| CHEMBL1200850 | ChEMBL_ID |
| DB01004 | DRUGBANK_ID |
| D015774 | MESH_DESCRIPTOR_UI |
| 135398740 | PUBCHEM_CID |
| 6023 | INN_ID |
| P9G3CKZ4P5 | UNII |
| 4678 | RXNORM |
| 177021 | MMSL |
| 33722 | MMSL |
| 34097 | MMSL |
| 47373 | MMSL |
| 4775 | MMSL |
| 4776 | MMSL |
| d00066 | MMSL |
| 003444 | NDDF |
| 003445 | NDDF |
| 372848001 | SNOMEDCT_US |
| 76587005 | SNOMEDCT_US |
| 78025001 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9299 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAVENOUS | ANDA | 29 sections |
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 14335-030 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAVENTRICULAR | ANDA | 30 sections |
| ZIRGAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-535 | GEL | 1.50 mg | OPHTHALMIC | NDA | 22 sections |
| ZIRGAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 24208-535 | GEL | 1.50 mg | OPHTHALMIC | NDA | 22 sections |
| ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-185 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 28 sections |
| ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-185 | INJECTION, SOLUTION | 50 mg | INTRAVENOUS | ANDA | 28 sections |
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42023-173 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 29 sections |
| GANCICLOVIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51754-2500 | INJECTION, SOLUTION | 2 mg | INTRAVENOUS | NDA | 18 sections |
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51817-171 | INJECTION, SOLUTION | 500 mg | INTRAVENOUS | ANDA | 29 sections |
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51817-171 | INJECTION, SOLUTION | 500 mg | INTRAVENOUS | ANDA | 29 sections |
| CytoveneIV | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61269-450 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | NDA | 31 sections |
| GANCICLOVIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63304-636 | CAPSULE | 250 mg | ORAL | ANDA | 23 sections |
| GANCICLOVIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63304-637 | CAPSULE | 500 mg | ORAL | ANDA | 23 sections |
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-315 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 32 sections |
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-315 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 32 sections |
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-315 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 32 sections |
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-315 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 32 sections |
| Ganciclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70436-089 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 500 mg | INTRAVENTRICULAR | ANDA | 29 sections |