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idoxuridine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| uridine derivatives used as antiviral agents and as antineoplastics | 1417 | 54-42-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An analog of DEOXYURIDINE that inhibits viral DNA synthesis. The drug is used as an antiviral agent.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MET,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 47 | |||
| kinase-selectivity-class | AXL,CDK9,GRK2,IRAK1,MAP2K6,MAP3K14,PDK1,PRKDC,TEK | 9 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | Moderate | 0.74 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| June 11, 1963 | FDA | ALLERGAN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D06BB01 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Antivirals |
| ATC | J05AB02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleosides and nucleotides excl. reverse transcriptase inhibitors |
| ATC | S01AD01 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antivirals |
| FDA EXT | N0000175459 | Nucleoside Analog |
| FDA EPC | N0000175466 | Nucleoside Analog Antiviral |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000998 | Antiviral Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D019384 | Nucleic Acid Synthesis Inhibitors |
| CHEBI has role | CHEBI:36044 | antiviral drugs |
| CHEBI has role | CHEBI:59517 | DNA synthesis inhibitors |
Related Drugs by ATC class:
D06BB Antivirals 11 drugs
J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors 11 drugs
S01AD Antivirals 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Herpes simplex keratitis | indication | 9389005 | |
| Vaccinia keratitis | off-label use | 397552005 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.03 | acidic |
| pKa2 | 13.02 | acidic |
| pKa3 | 13.7 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Thymidine kinase, cytosolic | Kinase | Ki | 7.05 | CHEMBL | |||||
| Thymidine kinase | Kinase | IC50 | 5.82 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018015 | VUID |
| N0000146359 | NUI |
| D00342 | KEGG_DRUG |
| 4018015 | VANDF |
| C0020811 | UMLSCUI |
| CHEBI:147675 | CHEBI |
| CHEMBL788 | ChEMBL_ID |
| DB00249 | DRUGBANK_ID |
| D007065 | MESH_DESCRIPTOR_UI |
| 5905 | PUBCHEM_CID |
| 1486 | INN_ID |
| LGP81V5245 | UNII |
| 360903 | RXNORM |
| 4866 | MMSL |
| 003011 | NDDF |
| 373499006 | SNOMEDCT_US |
| 49705006 | SNOMEDCT_US |
| ID2 | PDB_CHEM_ID |
Pharmaceutical products:
None