valaciclovir Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals bicyclic heterocycle compounds 2798 124832-27-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • valacyclovir
  • valaciclovir
  • valcivir
  • valacyclovir hydrochloride
  • valacyclovir HCl
A prodrug of acyclovir that is used in the treatment of HERPES ZOSTER and HERPES SIMPLEX VIRUS INFECTION of the skin and mucous membranes, including GENITAL HERPES.
  • Molecular weight: 324.34
  • Formula: C13H20N6O4
  • CLOGP: -1.22
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 3
  • TPSA: 146.85
  • ALOGS: -1.97
  • ROTB: 8

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 174 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 154.16 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
June 23, 1995 FDA GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Altered state of consciousness 289.05 9.72 244 66882 24592 53257348
Acute kidney injury 259.34 9.72 804 66322 253064 53028876
Encephalopathy 201.44 9.72 240 66886 36568 53245372
Febrile neutropenia 199.84 9.72 421 66705 104515 53177425
Plasma cell myeloma 198.62 9.72 272 66854 47602 53234338
Herpes zoster 189.98 9.72 337 66789 73682 53208258
Rheumatoid arthritis 188.60 9.72 80 67046 314451 52967489
Neurotoxicity 187.26 9.72 155 66971 15194 53266746
Toxic encephalopathy 174.95 9.72 103 67023 5824 53276116
Drug ineffective 155.69 9.72 520 66606 816725 52465215
Hepatocellular injury 145.44 9.72 184 66942 29802 53252138
Contraindicated product administered 144.77 9.72 6 67120 135623 53146317
Dysarthria 139.68 9.72 211 66915 40357 53241583
Dyslalia 137.03 9.72 44 67082 537 53281403
Herpes simplex 129.03 9.72 94 67032 7635 53274305
Drug reaction with eosinophilia and systemic symptoms 125.05 9.72 179 66947 32621 53249319
Cytokine release syndrome 120.37 9.72 92 67034 8037 53273903
Blood urea increased 119.42 9.72 156 66970 26075 53255865
Toxic skin eruption 115.07 9.72 110 67016 13029 53268911
Neutropenia 110.18 9.72 444 66682 158741 53123199
Oral herpes 109.16 9.72 134 66992 21045 53260895
Synovitis 102.45 9.72 9 67117 107884 53174056
Herpes virus infection 96.34 9.72 67 67059 5056 53276884
Drug hypersensitivity 92.37 9.72 119 67007 265123 53016817
Treatment failure 90.05 9.72 25 67101 128378 53153562
Pancytopenia 88.83 9.72 284 66842 90644 53191296
Agranulocytosis 86.71 9.72 127 66999 23622 53258318
Pyrexia 86.70 9.72 830 66296 402363 52879577
Glossodynia 86.05 9.72 12 67114 100279 53181661
Blood creatinine increased 81.49 9.72 259 66867 82403 53199537
Completed suicide 79.77 9.72 37 67089 138164 53143776
Rash maculo-papular 78.26 9.72 137 66989 29612 53252328
Systemic lupus erythematosus 78.12 9.72 30 67096 125384 53156556
Joint swelling 76.89 9.72 110 67016 234528 53047412
Thrombocytopenia 73.24 9.72 357 66769 138370 53143570
Febrile bone marrow aplasia 72.26 9.72 65 67061 7124 53274816
Nervous system disorder 70.54 9.72 98 67028 17366 53264574
Neuropathy peripheral 69.88 9.72 286 66840 102901 53179039
Intentional overdose 68.40 9.72 4 67122 67201 53214739
Drug intolerance 67.64 9.72 96 67030 205397 53076543
White blood cell count decreased 66.18 9.72 321 66805 124154 53157786
Laryngitis fungal 64.00 9.72 18 67108 134 53281806
Wound 62.03 9.72 19 67107 91538 53190402
Depressed level of consciousness 60.60 9.72 178 66948 54250 53227690
Therapeutic product effect decreased 56.65 9.72 45 67081 125610 53156330
Tumour lysis syndrome 56.20 9.72 59 67067 7815 53274125
Arthropathy 56.19 9.72 57 67069 141396 53140544
Drug abuse 55.83 9.72 8 67118 65518 53216422
Swelling 55.55 9.72 97 67029 191008 53090932
Alopecia 55.54 9.72 134 66992 234449 53047491
Platelet count decreased 51.97 9.72 271 66855 107828 53174112
Rectal prolapse 51.27 9.72 31 67095 1840 53280100
Diarrhoea 49.42 9.72 1080 66046 624466 52657474
Maternal exposure during pregnancy 48.96 9.72 75 67051 155564 53126376
Genital herpes 48.60 9.72 29 67097 1680 53280260
Acute generalised exanthematous pustulosis 46.56 9.72 61 67065 10220 53271720
Diffuse large B-cell lymphoma refractory 46.36 9.72 24 67102 1052 53280888
Injection site inflammation 45.74 9.72 36 67090 3282 53278658
Cytomegalovirus infection 45.06 9.72 85 67041 19454 53262486
Renal disorder 44.30 9.72 107 67019 29032 53252908
Encephalitis cytomegalovirus 43.85 9.72 19 67107 555 53281385
Abdominal discomfort 43.57 9.72 138 66988 220924 53061016
Graft versus host disease 41.53 9.72 48 67078 7074 53274866
Aplasia 40.36 9.72 37 67089 4155 53277785
Dermatitis exfoliative generalised 40.29 9.72 34 67092 3421 53278519
Septic shock 39.38 9.72 169 66957 62060 53219880
Pain 38.44 9.72 516 66610 587882 52694058
Bronchopulmonary aspergillosis 37.07 9.72 50 67076 8615 53273325
Delirium 36.49 9.72 125 67001 41304 53240636
Helicobacter infection 35.14 9.72 4 67122 39065 53242875
Hallucination, visual 35.13 9.72 75 67051 18757 53263183
Lymphopenia 34.85 9.72 70 67056 16773 53265167
Suicide attempt 32.89 9.72 16 67110 58152 53223788
Immune effector cell-associated neurotoxicity syndrome 32.16 9.72 19 67107 1081 53280859
Full blood count decreased 32.09 9.72 84 67042 23945 53257995
Cholestasis 32.08 9.72 94 67032 28601 53253339
Discomfort 31.98 9.72 44 67082 95428 53186512
Plasma cell myeloma recurrent 31.88 9.72 27 67099 2730 53279210
Skull malformation 31.20 9.72 13 67113 344 53281596
Toxic erythema of chemotherapy 30.71 9.72 10 67116 128 53281812
Arthralgia 30.39 9.72 381 66745 439402 52842538
Bladder prolapse 30.21 9.72 23 67103 1997 53279943
Acute myeloid leukaemia 29.95 9.72 66 67060 16866 53265074
Cerebellar stroke 29.78 9.72 11 67115 209 53281731
Myoclonus 29.66 9.72 63 67063 15701 53266239
Pericarditis 29.10 9.72 23 67103 64383 53217557
Therapeutic product effect incomplete 29.07 9.72 44 67082 91740 53190200
Rheumatoid factor positive 28.90 9.72 8 67118 41190 53240750
Urine output decreased 28.60 9.72 52 67074 11571 53270369
Toxicity to various agents 28.45 9.72 161 66965 219437 53062503
Laboratory test abnormal 28.28 9.72 81 67045 24328 53257612
Eosinophilia 27.90 9.72 74 67052 21261 53260679
Renal impairment 27.87 9.72 190 66936 83128 53198812
Dyspnoea 27.65 9.72 546 66580 585686 52696254
Asthma 27.57 9.72 60 67066 108912 53173028
Fungal endocarditis 27.21 9.72 11 67115 269 53281671
Post herpetic neuralgia 27.01 9.72 22 67104 2107 53279833
Human herpesvirus 6 encephalitis 26.39 9.72 9 67117 134 53281806
Ophthalmic herpes zoster 26.16 9.72 20 67106 1747 53280193
Disorientation 25.76 9.72 108 67018 39251 53242689
Loss of personal independence in daily activities 25.64 9.72 30 67096 69785 53212155
Deep vein thrombosis 25.35 9.72 185 66941 82728 53199212
Bacterial sepsis 25.31 9.72 28 67098 3934 53278006
Drug interaction 25.17 9.72 167 66959 219162 53062778
Renal tubular disorder 25.12 9.72 24 67102 2839 53279101
Product use issue 24.85 9.72 91 67035 139493 53142447
Neuropsychiatric syndrome 24.34 9.72 7 67119 57 53281883
Cytopenia 23.81 9.72 42 67084 9128 53272812
Genital herpes simplex 23.62 9.72 9 67117 187 53281753
Musculoskeletal stiffness 23.59 9.72 78 67048 123290 53158650
Blood uric acid increased 23.32 9.72 28 67098 4296 53277644
Mucormycosis 23.20 9.72 22 67104 2578 53279362
Serotonin syndrome 23.02 9.72 3 67123 26403 53255537
Cerebral ventricle dilatation 22.94 9.72 15 67111 1022 53280918
Eye infection bacterial 22.93 9.72 8 67118 128 53281812
Mobility decreased 22.79 9.72 38 67088 76233 53205707
Anaphylactic reaction 22.58 9.72 24 67102 58302 53223638
Bradycardia 22.56 9.72 34 67092 71022 53210918
Hypersensitivity 22.40 9.72 164 66962 210501 53071439
Restlessness 22.38 9.72 82 67044 28005 53253935
Infective aneurysm 22.22 9.72 11 67115 438 53281502
Decreased appetite 22.21 9.72 387 66739 214587 53067353
Impaired healing 22.10 9.72 29 67097 64176 53217764
Psychiatric symptom 21.83 9.72 29 67097 4924 53277016
Lymphocyte count decreased 21.60 9.72 81 67045 27971 53253969
Spina bifida 21.57 9.72 13 67113 767 53281173
Bicytopenia 21.12 9.72 19 67107 2082 53279858
Disseminated varicella zoster virus infection 20.83 9.72 13 67113 817 53281123
Lower respiratory tract infection 20.69 9.72 53 67073 90928 53191012
Mixed liver injury 20.45 9.72 25 67101 3908 53278032
International normalised ratio increased 20.41 9.72 18 67108 47743 53234197
Sepsis 20.26 9.72 277 66849 146152 53135788
Vitamin D decreased 20.16 9.72 38 67088 8691 53273249
Cryptosporidiosis infection 20.13 9.72 9 67117 284 53281656
Congenital herpes simplex infection 19.95 9.72 4 67122 4 53281936
Death 19.87 9.72 323 66803 356909 52925031
Plasmacytoma 19.61 9.72 20 67106 2561 53279379
Biopsy skin abnormal 19.51 9.72 7 67119 122 53281818
Confusional state 19.47 9.72 348 66778 193873 53088067
Pneumonia 19.40 9.72 659 66467 406510 52875430
Bone marrow failure 19.21 9.72 82 67044 30033 53251907
Vocal cord dysfunction 19.21 9.72 9 67117 317 53281623
Posterior reversible encephalopathy syndrome 19.09 9.72 54 67072 16106 53265834
Folliculitis 19.05 9.72 8 67118 31701 53250239
Hepatic cytolysis 19.05 9.72 35 67091 7850 53274090
Neutrophil count decreased 18.89 9.72 116 67010 48982 53232958
Pneumocystis jirovecii pneumonia 18.64 9.72 54 67072 16324 53265616
Terminal ileitis 18.50 9.72 11 67115 633 53281307
Cell death 18.48 9.72 19 67107 2456 53279484
Campylobacter colitis 18.43 9.72 5 67121 32 53281908
Vitiligo 18.19 9.72 14 67112 1235 53280705
Hyperthermia 18.19 9.72 36 67090 8533 53273407
Chronic lymphocytic leukaemia 18.17 9.72 21 67105 3095 53278845
Metabolic encephalopathy 18.09 9.72 29 67097 5832 53276108
Cardiac arrest 18.06 9.72 59 67067 93608 53188332
Speech disorder 17.97 9.72 97 67029 39084 53242856
Hepatic enzyme increased 17.72 9.72 90 67036 126105 53155835
Hallucination 17.54 9.72 122 67004 53716 53228224
Mucosal excoriation 17.44 9.72 4 67122 11 53281929
Ectropion 17.40 9.72 7 67119 169 53281771
Meningoencephalitis herpetic 17.11 9.72 13 67113 1125 53280815
Hepatitis 16.98 9.72 86 67040 33808 53248132
Mycetoma mycotic 16.95 9.72 4 67122 13 53281927
Cytomegalovirus chorioretinitis 16.75 9.72 15 67111 1634 53280306
Tractional retinal detachment 16.75 9.72 5 67121 47 53281893
Cholecystitis chronic 16.39 9.72 39 67087 10479 53271461
Infective chondritis 16.30 9.72 4 67122 16 53281924
Kussmaul respiration 16.27 9.72 7 67119 201 53281739
Cardiac failure congestive 16.16 9.72 61 67065 92696 53189244
Pseudolymphoma 16.13 9.72 10 67116 621 53281319
Soliloquy 16.04 9.72 7 67119 208 53281732
Rhabdomyolysis 15.99 9.72 19 67107 43904 53238036
Bacterial vaginosis 15.73 9.72 12 67114 1045 53280895
Chronic papillomatous dermatitis 15.65 9.72 5 67121 60 53281880
Escherichia bacteraemia 15.56 9.72 20 67106 3288 53278652
Metastases to liver 15.41 9.72 4 67122 21492 53260448
Laryngeal inflammation 15.26 9.72 6 67120 136 53281804
Wrong technique in product usage process 15.22 9.72 33 67093 59999 53221941
Blood pressure systolic abnormal 15.16 9.72 30 67096 7109 53274831
Hypoglycaemic seizure 15.09 9.72 9 67117 521 53281419
Coronary artery disease 15.03 9.72 12 67114 33425 53248515
Citrobacter sepsis 14.96 9.72 3 67123 3 53281937
Drug monitoring procedure not performed 14.95 9.72 9 67117 530 53281410
Thermal burn 14.94 9.72 25 67101 5208 53276732
Pseudomyopia 14.88 9.72 5 67121 71 53281869
Bone marrow necrosis 14.82 9.72 5 67121 72 53281868
Central nervous system necrosis 14.79 9.72 6 67120 148 53281792
Gastrointestinal disorder 14.53 9.72 61 67065 89943 53191997
Acute pulmonary oedema 14.40 9.72 32 67094 8223 53273717
Lichenification 14.37 9.72 8 67118 406 53281534
Renal failure 14.36 9.72 219 66907 118233 53163707
Ophthalmic herpes simplex 14.36 9.72 8 67118 407 53281533
Cytomegalovirus colitis 14.23 9.72 15 67111 1995 53279945
Accidental exposure to product 14.18 9.72 6 67120 23668 53258272
Coordination abnormal 14.18 9.72 40 67086 11911 53270029
Rhegmatogenous retinal detachment 14.16 9.72 5 67121 83 53281857
Aspergillus infection 14.15 9.72 30 67096 7466 53274474
Hepatitis E 13.84 9.72 12 67114 1252 53280688
Hepatitis acute 13.83 9.72 33 67093 8883 53273057
Hip arthroplasty 13.82 9.72 9 67117 27853 53254087
Epstein-Barr virus associated lymphoma 13.79 9.72 8 67118 440 53281500
Skin lesion 13.77 9.72 72 67054 28657 53253283
Antiviral drug level above therapeutic 13.75 9.72 3 67123 6 53281934
Congenital pyelocaliectasis 13.75 9.72 3 67123 6 53281934
Neurosis 13.52 9.72 7 67119 307 53281633
Pharyngeal inflammation 13.50 9.72 9 67117 633 53281307
Eye infection toxoplasmal 13.48 9.72 7 67119 309 53281631
C-reactive protein abnormal 13.33 9.72 8 67118 25862 53256078
Epstein-Barr virus infection 13.21 9.72 29 67097 7389 53274551
Pulmonary arterial hypertension 13.14 9.72 9 67117 27113 53254827
Peripheral swelling 12.93 9.72 182 66944 205926 53076014
Pain in extremity 12.93 9.72 267 66859 284783 52997157
Tri-iodothyronine free increased 12.92 9.72 6 67120 207 53281733
Thrombosis 12.90 9.72 125 67001 60668 53221272
Sedation 12.90 9.72 11 67115 29664 53252276
Meningocele 12.89 9.72 3 67123 9 53281931
Autoimmune nephritis 12.86 9.72 7 67119 340 53281600
Pyelitis 12.68 9.72 6 67120 216 53281724
Dermatitis exfoliative 12.67 9.72 25 67101 5911 53276029
Human ehrlichiosis 12.66 9.72 6 67120 217 53281723
Mycobacterial peritonitis 12.61 9.72 5 67121 116 53281824
Leukaemia recurrent 12.59 9.72 12 67114 1415 53280525
Cardiomyopathy acute 12.53 9.72 6 67120 222 53281718
Infusion related reaction 12.33 9.72 131 66995 155826 53126114
Venoocclusive disease 12.23 9.72 14 67112 2041 53279899
Myocardial infarction 12.23 9.72 74 67052 99280 53182660
Pathogen resistance 12.09 9.72 26 67100 6534 53275406
Irritable bowel syndrome 11.90 9.72 23 67103 43609 53238331
Squamous cell carcinoma of skin 11.82 9.72 23 67103 5384 53276556
Hepatitis cholestatic 11.80 9.72 27 67099 7072 53274868
Knee arthroplasty 11.71 9.72 15 67111 33554 53248386
Rash pustular 11.66 9.72 27 67099 7129 53274811
Incoherent 11.62 9.72 21 67105 4651 53277289
Angina bullosa haemorrhagica 11.61 9.72 5 67121 144 53281796
Anal infection 11.52 9.72 4 67122 63 53281877
Gamma-glutamyltransferase increased 11.50 9.72 77 67049 33478 53248462
Acute myocardial infarction 11.44 9.72 15 67111 33220 53248720
Chronic obstructive pulmonary disease 11.41 9.72 39 67087 61034 53220906
Dermo-hypodermitis 11.38 9.72 6 67120 273 53281667
Therapeutic response decreased 11.37 9.72 27 67099 47542 53234398
Thrombotic thrombocytopenic purpura 11.37 9.72 19 67107 3955 53277985
Embedded device 11.35 9.72 17 67109 3224 53278716
Acute febrile neutrophilic dermatosis 11.30 9.72 16 67110 2885 53279055
Herpes ophthalmic 11.29 9.72 10 67116 1074 53280866
Varicella zoster virus infection 11.28 9.72 15 67111 2548 53279392
Nystagmus 11.21 9.72 24 67102 6012 53275928
Psychiatric decompensation 11.17 9.72 11 67115 1351 53280589
Diabetes mellitus 11.06 9.72 33 67093 53866 53228074
Progressive multifocal leukoencephalopathy 11.03 9.72 37 67089 12092 53269848
Hypouricaemia 11.03 9.72 5 67121 163 53281777
Graft versus host disease in gastrointestinal tract 10.99 9.72 16 67110 2958 53278982
Foreign body in reproductive tract 10.96 9.72 7 67119 458 53281482
Pneumocystis jirovecii infection 10.93 9.72 11 67115 1386 53280554
Tumour flare 10.84 9.72 6 67120 301 53281639
Hypoglycaemia 10.81 9.72 38 67088 58975 53222965
Grimacing 10.78 9.72 7 67119 471 53281469
Escherichia pyelonephritis 10.77 9.72 7 67119 472 53281468
Lymphocyte morphology abnormal 10.72 9.72 7 67119 476 53281464
CSF cell count increased 10.71 9.72 3 67123 22 53281918
Hemianopia homonymous 10.70 9.72 8 67118 676 53281264
Neuralgia 10.63 9.72 58 67068 23463 53258477
Toxic epidermal necrolysis 10.59 9.72 58 67068 23492 53258448
Leukoencephalopathy 10.52 9.72 19 67107 4205 53277735
Disseminated cytomegaloviral infection 10.44 9.72 5 67121 185 53281755
Neurological symptom 10.41 9.72 21 67105 5048 53276892
Red blood cell sedimentation rate increased 10.36 9.72 12 67114 28045 53253895
Gastrointestinal haemorrhage 10.33 9.72 59 67067 80271 53201669
Cerebral thrombosis 10.30 9.72 12 67114 1783 53280157
Haemophagocytic lymphohistiocytosis 10.27 9.72 30 67096 9107 53272833
Cholestatic liver injury 10.27 9.72 14 67112 2437 53279503
Aminoaciduria 10.17 9.72 5 67121 196 53281744
Oliguria 10.07 9.72 30 67096 9208 53272732
Partial seizures with secondary generalisation 9.99 9.72 6 67120 352 53281588
Angioedema 9.96 9.72 24 67102 42052 53239888
Constipation 9.89 9.72 323 66803 198089 53083851
Erythema annulare 9.85 9.72 4 67122 99 53281841
Chills 9.84 9.72 186 66940 104662 53177278
Erythema multiforme 9.80 9.72 32 67094 10317 53271623
Nausea 9.79 9.72 1090 66036 755001 52526939
Streptococcal bacteraemia 9.78 9.72 11 67115 1573 53280367
Inappropriate antidiuretic hormone secretion 9.76 9.72 41 67085 14910 53267030

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 311.46 10.95 619 50154 118947 32343806
Cytokine release syndrome 179.14 10.95 157 50616 13378 32449375
Plasma cell myeloma 170.20 10.95 315 50458 57299 32405454
Neurotoxicity 149.67 10.95 149 50624 14921 32447832
Pyrexia 146.14 10.95 925 49848 319043 32143710
Encephalopathy 144.86 10.95 220 50553 34037 32428716
Neutropenia 140.35 10.95 514 50259 141661 32321092
Herpes zoster 135.76 10.95 207 50566 32134 32430619
Acute generalised exanthematous pustulosis 126.22 10.95 95 50678 6518 32456235
Febrile bone marrow aplasia 120.24 10.95 102 50671 8313 32454440
Agranulocytosis 115.53 10.95 162 50611 23315 32439438
Thrombocytopenia 114.82 10.95 497 50276 147802 32314951
Completed suicide 113.51 10.95 8 50765 92509 32370244
Toxic encephalopathy 102.84 10.95 75 50698 4902 32457851
Drug abuse 101.21 10.95 6 50767 80237 32382516
Pancytopenia 100.34 10.95 342 50431 90893 32371860
Drug reaction with eosinophilia and systemic symptoms 98.86 10.95 180 50593 32305 32430448
Hepatocellular injury 95.06 10.95 154 50619 25164 32437589
Rash maculo-papular 91.33 10.95 160 50613 27862 32434891
Dyslalia 86.18 10.95 33 50740 554 32462199
Acute kidney injury 83.62 10.95 760 50013 292708 32170045
Neuropathy peripheral 83.24 10.95 287 50486 76695 32386058
Altered state of consciousness 82.85 10.95 134 50639 21863 32440890
Toxic skin eruption 82.17 10.95 96 50677 11518 32451235
Toxicity to various agents 80.27 10.95 96 50677 177945 32284808
Nervous system disorder 79.84 10.95 104 50669 13945 32448808
Dysarthria 74.53 10.95 162 50611 33039 32429714
Dermatitis exfoliative generalised 73.37 10.95 52 50721 3249 32459504
Drug ineffective 71.12 10.95 333 50440 383144 32079609
Bronchopulmonary aspergillosis 69.64 10.95 96 50677 13591 32449162
Pneumonia 69.63 10.95 853 49920 354399 32108354
Microsporidia infection 63.54 10.95 27 50746 600 32462153
White blood cell count decreased 61.02 10.95 293 50480 90905 32371848
Drug interaction 57.11 10.95 164 50609 218021 32244732
Tumour lysis syndrome 52.58 10.95 87 50686 14460 32448293
Cytopenia 48.83 10.95 69 50704 9995 32452758
Face oedema 47.45 10.95 74 50699 11701 32451052
Graft versus host disease 46.49 10.95 70 50703 10736 32452017
Demodicidosis 46.40 10.95 15 50758 148 32462605
Acute myeloid leukaemia 43.52 10.95 94 50679 19080 32443673
Cerebral toxoplasmosis 42.62 10.95 28 50745 1544 32461209
Chronic lymphocytic leukaemia 40.74 10.95 44 50729 4841 32457912
Intentional overdose 40.24 10.95 8 50765 41593 32421160
Genital herpes 38.68 10.95 19 50754 596 32462157
Herpes simplex 38.67 10.95 44 50729 5130 32457623
Cholestasis 38.57 10.95 111 50662 26922 32435831
Squamous cell carcinoma of skin 38.55 10.95 61 50712 9765 32452988
Dyspnoea 38.45 10.95 371 50402 361674 32101079
Suicide attempt 37.74 10.95 7 50766 38237 32424516
Aplasia 37.03 10.95 40 50733 4402 32458351
Septic shock 36.01 10.95 207 50566 68782 32393971
Graft versus host disease in gastrointestinal tract 35.97 10.95 35 50738 3406 32459347
Lung disorder 35.70 10.95 125 50648 33629 32429124
Platelet count decreased 35.67 10.95 303 50470 114288 32348465
Pseudomonas infection 35.64 10.95 66 50707 11990 32450763
Hypoglycaemia 34.62 10.95 21 50752 54361 32408392
Nephritis allergic 33.41 10.95 16 50757 474 32462279
Ophthalmic herpes simplex 31.90 10.95 13 50760 259 32462494
Death 31.89 10.95 414 50359 382103 32080650
Eosinophilia 31.37 10.95 98 50675 24860 32437893
Mucosal inflammation 30.47 10.95 118 50655 33316 32429437
Pericarditis 29.85 10.95 53 50720 9320 32453433
International normalised ratio increased 29.75 10.95 20 50753 49015 32413738
Inappropriate schedule of product administration 28.75 10.95 18 50755 45807 32416946
Pulmonary sarcoidosis 28.38 10.95 15 50758 550 32462203
Myocardial infarction 28.25 10.95 101 50672 125575 32337178
Congenital herpes simplex infection 27.67 10.95 8 50765 52 32462701
Confusional state 27.56 10.95 343 50430 142772 32319981
Squamous cell carcinoma 27.48 10.95 56 50717 10912 32451841
Intentional product misuse 27.36 10.95 11 50762 36040 32426713
Drug hypersensitivity 26.67 10.95 46 50727 73354 32389399
Lymphopenia 26.33 10.95 65 50708 14391 32448362
Differentiation syndrome 26.15 10.95 19 50754 1234 32461519
Wrong technique in product usage process 26.11 10.95 11 50762 35048 32427705
Depression 26.04 10.95 72 50701 96988 32365765
Rhinovirus infection 25.74 10.95 29 50744 3344 32459409
Plasma cell myeloma recurrent 25.69 10.95 31 50742 3846 32458907
Thrombotic microangiopathy 25.67 10.95 50 50723 9432 32453321
Pathogen resistance 25.56 10.95 50 50723 9460 32453293
Infective exacerbation of chronic obstructive airways disease 25.55 10.95 22 50751 1829 32460924
Conjunctival irritation 25.33 10.95 9 50764 121 32462632
Encephalitis 25.28 10.95 42 50731 7002 32455751
Bradycardia 24.96 10.95 46 50727 71516 32391237
Parainfluenzae virus infection 24.86 10.95 24 50749 2313 32460440
Rhabdomyolysis 24.58 10.95 42 50731 67223 32395530
Varicella zoster virus infection 24.54 10.95 20 50753 1541 32461212
Full blood count decreased 24.41 10.95 70 50703 16940 32445813
Eosinophilic colitis 24.23 10.95 10 50763 206 32462547
Human herpesvirus 6 encephalitis 23.75 10.95 10 50763 217 32462536
Neutrophil count decreased 23.01 10.95 139 50634 47000 32415753
Escherichia sepsis 22.87 10.95 31 50742 4317 32458436
Ichthyosis 22.76 10.95 8 50765 104 32462649
Psychiatric symptom 22.62 10.95 28 50745 3566 32459187
Tumour flare 22.50 10.95 13 50760 569 32462184
Delirium 22.22 10.95 131 50642 43915 32418838
Injection site pain 22.13 10.95 12 50761 33046 32429707
Hepatitis cholestatic 21.81 10.95 43 50730 8182 32454571
Nocardiosis 21.79 10.95 28 50745 3703 32459050
Drug dependence 21.72 10.95 5 50768 23479 32439274
Rash 21.52 10.95 452 50321 208881 32253872
Botryomycosis 21.45 10.95 6 50767 34 32462719
Genital erythema 21.22 10.95 9 50764 199 32462554
Malignant neoplasm progression 21.22 10.95 58 50715 78438 32384315
Malignant neoplasm of unknown primary site 21.03 10.95 11 50762 395 32462358
Anxiety 21.01 10.95 78 50695 95927 32366826
Purpura 20.97 10.95 49 50724 10476 32452277
JC virus infection 20.53 10.95 20 50753 1949 32460804
Immune effector cell-associated neurotoxicity syndrome 20.36 10.95 18 50755 1550 32461203
Aggression 20.21 10.95 19 50754 39370 32423383
Angina pectoris 20.19 10.95 12 50761 31414 32431339
Hallucination 20.13 10.95 146 50627 52473 32410280
Respiratory arrest 20.08 10.95 10 50763 28898 32433855
Drug withdrawal syndrome 19.33 10.95 4 50769 20227 32442526
Hyperthermia 19.29 10.95 48 50725 10680 32452073
Glomerulosclerosis 19.20 10.95 13 50760 754 32461999
Morganella infection 19.19 10.95 11 50762 474 32462279
Cardiac arrest 19.04 10.95 82 50691 96694 32366059
Acute myocardial infarction 18.75 10.95 36 50737 55113 32407640
Anti-cyclic citrullinated peptide antibody positive 18.66 10.95 13 50760 790 32461963
Disseminated cryptococcosis 18.59 10.95 15 50758 1139 32461614
Hyperuricaemia 18.57 10.95 40 50733 8101 32454652
Ophthalmic herpes zoster 18.53 10.95 13 50760 799 32461954
Logorrhoea 18.50 10.95 21 50752 2441 32460312
Stress 18.47 10.95 7 50766 23775 32438978
Atrial fibrillation 18.45 10.95 270 50503 116434 32346319
Coronary artery disease 18.19 10.95 31 50742 49675 32413078
Hyperleukocytosis 18.19 10.95 18 50755 1788 32460965
Haemorrhoids thrombosed 18.07 10.95 8 50765 197 32462556
Angioedema 18.04 10.95 18 50755 36271 32426482
Product quality issue 17.98 10.95 4 50769 19229 32443524
Incorrect disposal of product 17.63 10.95 9 50764 307 32462446
Brief psychotic disorder with marked stressors 17.53 10.95 8 50765 212 32462541
Dyscalculia 17.50 10.95 5 50768 31 32462722
CSF cell count increased 17.50 10.95 5 50768 31 32462722
Hyperhidrosis 17.48 10.95 55 50718 71113 32391640
Positive end-expiratory pressure 17.47 10.95 4 50769 8 32462745
SARS-CoV-2 sepsis 17.34 10.95 7 50766 136 32462617
Bronchopneumopathy 17.28 10.95 10 50763 439 32462314
Influenza 17.22 10.95 127 50646 45887 32416866
Depressed level of consciousness 17.19 10.95 116 50657 40731 32422022
Laryngeal cancer metastatic 17.14 10.95 6 50767 77 32462676
Cytomegalovirus infection 17.13 10.95 82 50691 25382 32437371
Bacillus bacteraemia 17.07 10.95 6 50767 78 32462675
Polymyositis 17.03 10.95 16 50757 1490 32461263
Aspergillus infection 16.97 10.95 48 50725 11526 32451227
Hypercalcaemia 16.95 10.95 54 50719 13840 32448913
Hallucination, visual 16.82 10.95 62 50711 17097 32445656
Pain 16.68 10.95 200 50573 187356 32275397
Mutism 16.67 10.95 12 50761 768 32461985
Herpes virus infection 16.46 10.95 21 50752 2757 32459996
Hypercapnic coma 16.21 10.95 7 50766 162 32462591
Periorbital cellulitis 16.11 10.95 8 50765 257 32462496
Pityriasis rubra pilaris 16.11 10.95 6 50767 93 32462660
Myelodysplastic syndrome 16.08 10.95 68 50705 19970 32442783
Blood creatine phosphokinase increased 16.06 10.95 29 50744 45447 32417306
Fall 16.04 10.95 213 50560 195988 32266765
Sepsis 15.99 10.95 342 50431 158492 32304261
Myositis 15.89 10.95 46 50727 11189 32451564
Complications of transplanted heart 15.88 10.95 8 50765 265 32462488
Chest pain 15.88 10.95 121 50652 124016 32338737
Herpes zoster reactivation 15.86 10.95 8 50765 266 32462487
Infection 15.84 10.95 202 50571 84513 32378240
Venous thrombosis 15.69 10.95 23 50750 3444 32459309
Escherichia bacteraemia 15.67 10.95 22 50751 3167 32459586
Arthritis fungal 15.60 10.95 6 50767 102 32462651
Citrobacter infection 15.59 10.95 10 50763 529 32462224
Cerebellar syndrome 15.48 10.95 18 50755 2148 32460605
Lymphocytic infiltration 15.20 10.95 11 50762 710 32462043
Bronchial haemorrhage 15.17 10.95 11 50762 712 32462041
Blood pressure increased 15.14 10.95 68 50705 79286 32383467
Graft versus host disease in lung 15.08 10.95 10 50763 560 32462193
Pneumonia pneumococcal 15.02 10.95 17 50756 1970 32460783
Hypogammaglobulinaemia 14.85 10.95 31 50742 6145 32456608
Aeromonas infection 14.80 10.95 8 50765 307 32462446
Haematochezia 14.76 10.95 24 50749 39184 32423569
Wound evisceration 14.66 10.95 6 50767 121 32462632
Dermatitis exfoliative 14.59 10.95 35 50738 7609 32455144
Blood creatinine abnormal 14.57 10.95 18 50755 2287 32460466
Pneumonia fungal 14.49 10.95 31 50742 6249 32456504
Wheezing 14.43 10.95 22 50751 36852 32425901
Haemolytic anaemia 14.40 10.95 43 50730 10641 32452112
Basal cell carcinoma 14.40 10.95 60 50713 17508 32445245
Bacterial sepsis 14.38 10.95 28 50745 5280 32457473
Metabolic acidosis 14.33 10.95 26 50747 40673 32422080
Blood osmolarity abnormal 14.32 10.95 3 50770 3 32462750
Folliculitis 14.25 10.95 25 50748 4355 32458398
Serotonin syndrome 14.23 10.95 6 50767 19111 32443642
Lymphocyte count decreased 14.20 10.95 68 50705 21051 32441702
Disorientation 14.11 10.95 95 50678 33330 32429423
Renal disorder 14.08 10.95 77 50696 25106 32437647
Drug resistance 14.06 10.95 72 50701 22893 32439860
Therapeutic product effect incomplete 14.04 10.95 27 50746 41314 32421439
Serum sickness 13.91 10.95 16 50757 1887 32460866
Enterococcal sepsis 13.83 10.95 15 50758 1658 32461095
Flushing 13.76 10.95 17 50756 31110 32431643
Benign neoplasm of skin 13.63 10.95 5 50768 74 32462679
Sleep disorder 13.61 10.95 13 50760 26739 32436014
CSF volume increased 13.58 10.95 4 50769 28 32462725
Gastrointestinal haemorrhage 13.45 10.95 80 50693 86802 32375951
Haematemesis 13.40 10.95 14 50759 27621 32435132
Retinal detachment 13.39 10.95 27 50746 5221 32457532
Diffuse large B-cell lymphoma 13.30 10.95 36 50737 8426 32454327
Melaena 13.26 10.95 21 50752 34644 32428109
Hemiparesis 13.15 10.95 4 50769 15603 32447150
Donor leukocyte infusion 13.12 10.95 4 50769 32 32462721
Adverse drug reaction 13.09 10.95 77 50696 25784 32436969
Musculoskeletal stiffness 13.02 10.95 26 50747 39238 32423515
Pneumonia aspiration 13.02 10.95 28 50745 41128 32421625
Streptococcal bacteraemia 12.93 10.95 15 50758 1785 32460968
Amyotrophy 12.92 10.95 9 50764 547 32462206
Escherichia infection 12.83 10.95 32 50741 7128 32455625
Oesophagitis 12.80 10.95 47 50726 12934 32449819
Monoclonal immunoglobulin present 12.64 10.95 11 50762 927 32461826
Medication error 12.62 10.95 10 50763 22525 32440228
Cerebrovascular accident 12.57 10.95 81 50692 86239 32376514
Arthralgia 12.54 10.95 160 50613 148288 32314465
Feeding disorder 12.53 10.95 30 50743 6515 32456238
Renal ischaemia 12.46 10.95 9 50764 579 32462174
Blood lactate dehydrogenase increased 12.41 10.95 67 50706 21738 32441015
Facial paralysis 12.39 10.95 40 50733 10321 32452432
Loss of consciousness 12.36 10.95 77 50696 82630 32380123
Gastric varices 12.08 10.95 8 50765 447 32462306
Herpes zoster oticus 12.03 10.95 5 50768 105 32462648
Chronic kidney disease 11.99 10.95 28 50745 39947 32422806
Rheumatoid arthritis 11.97 10.95 33 50740 44511 32418242
Macular fibrosis 11.95 10.95 8 50765 455 32462298
Photosensitivity reaction 11.94 10.95 39 50734 10124 32452629
Wrong strength 11.94 10.95 5 50768 107 32462646
Oral mucosal erythema 11.92 10.95 8 50765 457 32462296
Oral herpes 11.91 10.95 25 50748 4972 32457781
Hospitalisation 11.91 10.95 38 50735 48933 32413820
Stem cell transplant 11.90 10.95 16 50757 2211 32460542
Mixed dementia 11.88 10.95 7 50766 318 32462435
Parvovirus B19 infection 11.87 10.95 9 50764 624 32462129
Aphasia 11.86 10.95 64 50709 20764 32441989
Respiratory depression 11.85 10.95 3 50770 13208 32449545
Retinitis 11.84 10.95 7 50766 320 32462433
Stomatitis 11.77 10.95 105 50668 40124 32422629
Lymphocytic lymphoma 11.67 10.95 4 50769 48 32462705
Pain in extremity 11.65 10.95 124 50649 118777 32343976
Pulmonary hypertension 11.59 10.95 9 50764 20485 32442268
Plasmacytoma 11.44 10.95 20 50753 3473 32459280
Rash erythematous 11.30 10.95 70 50703 23869 32438884
Diabetic ketoacidosis 11.30 10.95 7 50766 17925 32444828
Contraindicated product administered 11.28 10.95 8 50765 19068 32443685
Pneumonia haemophilus 11.23 10.95 7 50766 352 32462401
Blood glucose increased 11.23 10.95 58 50715 65183 32397570
Respiratory tract infection 11.12 10.95 55 50718 17250 32445503
Deep vein thrombosis 11.10 10.95 150 50623 63563 32399190
T-cell prolymphocytic leukaemia 11.05 10.95 4 50769 57 32462696
Congenital brain damage 11.04 10.95 3 50770 15 32462738
Blood osmolarity 11.04 10.95 3 50770 15 32462738

Pharmacologic Action:

SourceCodeDescription
ATC J05AB11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
FDA MoA N0000020060 DNA Polymerase Inhibitors
FDA EXT N0000175459 Nucleoside Analog
FDA EPC N0000175468 Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
FDA EPC N0000180187 Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor
FDA EPC N0000180188 Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Herpes labialis indication 1475003
Herpes zoster indication 4740000 DOID:8536
Genital herpes simplex indication 33839006 DOID:8704
Varicella indication 38907003 DOID:8659
Recurrent genital herpes simplex indication 402894005
Suppression of Recurrent Herpes Simplex Infection in HIV indication
Suppression of Recurrent Herpes Simplex Infection indication
Prevention of Cytomegalovirus Disease off-label use
Prevention of Herpes Zoster in Immunocompromised Patient off-label use
Dehydration contraindication 34095006
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Hemolytic uremic syndrome contraindication 111407006 DOID:12554
Impaired renal function disorder contraindication 197663003

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.97 acidic
pKa2 7.83 Basic
pKa3 3.83 Basic
pKa4 2.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA polymerase catalytic subunit Enzyme INHIBITOR WOMBAT-PK CHEMBL

External reference:

IDSource
4024006 VUID
N0000022011 NUI
D08664 KEGG_DRUG
124832-26-4 SECONDARY_CAS_RN
4020944 VANDF
4024006 VANDF
C0249458 UMLSCUI
CHEBI:9919 CHEBI
TXC PDB_CHEM_ID
CHEMBL1349 ChEMBL_ID
CHEMBL1201110 ChEMBL_ID
DB00577 DRUGBANK_ID
4824 IUPHAR_LIGAND_ID
7106 INN_ID
MZ1IW7Q79D UNII
135398742 PUBCHEM_CID
236081 RXNORM
169290 MMSL
5660 MMSL
d03838 MMSL
005049 NDDF
005050 NDDF
324820003 SNOMEDCT_US
412325002 SNOMEDCT_US
96098007 SNOMEDCT_US
D000077483 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0565 TABLET, FILM COATED 1 g ORAL NDA 25 sections
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0933 TABLET, FILM COATED 500 mg ORAL NDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-4275 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-4276 TABLET, FILM COATED 1 g ORAL ANDA 27 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-5208 TABLET 500 mg ORAL ANDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-5209 TABLET 1 g ORAL ANDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6565 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
valacyclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-937 TABLET, FILM COATED 1 g ORAL ANDA 23 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 16714-697 TABLET, FILM COATED 1 g ORAL ANDA 25 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 16714-698 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-832 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-965 TABLET, FILM COATED 1 g ORAL ANDA 27 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 31722-704 TABLET, FILM COATED 500 mg ORAL ANDA 24 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 31722-705 TABLET, FILM COATED 1 g ORAL ANDA 24 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-730 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 43063-771 TABLET, FILM COATED 1 g ORAL ANDA 24 sections
Valacyclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-778 TABLET 500 mg ORAL ANDA 26 sections
Valacyclovir Human Prescription Drug Label 1 43353-883 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 49483-690 TABLET 500 mg ORAL ANDA 26 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 49483-691 TABLET 1 g ORAL ANDA 26 sections
Valacyclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-1735 TABLET 500 mg ORAL ANDA 26 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-2223 TABLET, FILM COATED 1 g ORAL ANDA 27 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-2223 TABLET, FILM COATED 1 g ORAL ANDA 27 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-2224 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-2224 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Valacyclovir Human Prescription Drug Label 1 50090-2510 TABLET, FILM COATED 500 mg ORAL ANDA 24 sections
Valacyclovir Human Prescription Drug Label 1 50090-2510 TABLET, FILM COATED 500 mg ORAL ANDA 24 sections
Valacyclovir Human Prescription Drug Label 1 50090-2575 TABLET, FILM COATED 1 g ORAL ANDA 24 sections
Valacyclovir Human Prescription Drug Label 1 50090-2575 TABLET, FILM COATED 1 g ORAL ANDA 24 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-3875 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections