Stem definition | Drug id | CAS RN |
---|---|---|
antivirals bicyclic heterocycle compounds | 2798 | 124832-27-5 |
Dose | Unit | Route |
---|---|---|
3 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 174 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 154.16 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Date | Agency | Company | Orphan |
---|---|---|---|
June 23, 1995 | FDA | GLAXOSMITHKLINE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Altered state of consciousness | 318.81 | 9.91 | 251 | 71057 | 22770 | 56197989 |
Acute kidney injury | 305.88 | 9.91 | 828 | 70480 | 239935 | 55980824 |
Febrile neutropenia | 246.57 | 9.91 | 463 | 70845 | 105082 | 56115677 |
Rheumatoid arthritis | 239.22 | 9.91 | 93 | 71215 | 382511 | 55838248 |
Plasma cell myeloma | 227.63 | 9.91 | 288 | 71020 | 46358 | 56174401 |
Neurotoxicity | 216.05 | 9.91 | 171 | 71137 | 15624 | 56205135 |
Encephalopathy | 204.76 | 9.91 | 238 | 71070 | 35087 | 56185672 |
Contraindicated product administered | 201.27 | 9.91 | 8 | 71300 | 186278 | 56034481 |
Toxic encephalopathy | 198.07 | 9.91 | 112 | 71196 | 5826 | 56214933 |
Herpes zoster | 187.31 | 9.91 | 341 | 70967 | 75548 | 56145211 |
Pemphigus | 183.83 | 9.91 | 3 | 71305 | 157209 | 56063550 |
Drug ineffective | 183.17 | 9.91 | 579 | 70729 | 918410 | 55302349 |
Cytokine release syndrome | 173.43 | 9.91 | 129 | 71179 | 10746 | 56210013 |
Synovitis | 170.68 | 9.91 | 8 | 71300 | 161297 | 56059462 |
Hepatocellular injury | 164.40 | 9.91 | 185 | 71123 | 26329 | 56194430 |
Hand deformity | 155.45 | 9.91 | 3 | 71305 | 134489 | 56086270 |
Toxic skin eruption | 149.72 | 9.91 | 122 | 71186 | 11617 | 56209142 |
Drug reaction with eosinophilia and systemic symptoms | 149.22 | 9.91 | 188 | 71120 | 30116 | 56190643 |
Glossodynia | 148.02 | 9.91 | 12 | 71296 | 152446 | 56068313 |
Neutropenia | 147.36 | 9.91 | 488 | 70820 | 157679 | 56063080 |
Dysarthria | 147.01 | 9.91 | 214 | 71094 | 39336 | 56181423 |
Dyslalia | 146.39 | 9.91 | 44 | 71264 | 421 | 56220338 |
Systemic lupus erythematosus | 135.52 | 9.91 | 31 | 71277 | 180047 | 56040712 |
Oral herpes | 127.27 | 9.91 | 151 | 71157 | 22739 | 56198020 |
Herpes simplex | 126.23 | 9.91 | 92 | 71216 | 7426 | 56213333 |
Treatment failure | 124.93 | 9.91 | 31 | 71277 | 170361 | 56050398 |
Blood urea increased | 123.96 | 9.91 | 154 | 71154 | 24319 | 56196440 |
Agranulocytosis | 115.43 | 9.91 | 143 | 71165 | 22516 | 56198243 |
Wound | 114.73 | 9.91 | 19 | 71289 | 138785 | 56081974 |
Drug intolerance | 110.04 | 9.91 | 104 | 71204 | 264714 | 55956045 |
Joint swelling | 110.03 | 9.91 | 123 | 71185 | 289677 | 55931082 |
Arthropathy | 106.02 | 9.91 | 61 | 71247 | 200214 | 56020545 |
Pancytopenia | 96.57 | 9.91 | 289 | 71019 | 88426 | 56132333 |
Drug hypersensitivity | 95.76 | 9.91 | 125 | 71183 | 275080 | 55945679 |
Herpes virus infection | 95.37 | 9.91 | 67 | 71241 | 5103 | 56215656 |
Therapeutic product effect decreased | 94.95 | 9.91 | 48 | 71260 | 169404 | 56051355 |
Swelling | 90.72 | 9.91 | 102 | 71206 | 239669 | 55981090 |
Thrombocytopenia | 87.36 | 9.91 | 373 | 70935 | 135851 | 56084908 |
Rash maculo-papular | 87.15 | 9.91 | 142 | 71166 | 28765 | 56191994 |
Alopecia | 85.95 | 9.91 | 150 | 71158 | 293308 | 55927451 |
White blood cell count decreased | 82.35 | 9.91 | 347 | 70961 | 125643 | 56095116 |
Neuropathy peripheral | 82.31 | 9.91 | 302 | 71006 | 102591 | 56118168 |
Completed suicide | 81.04 | 9.91 | 34 | 71274 | 133799 | 56086960 |
Abdominal discomfort | 80.95 | 9.91 | 142 | 71166 | 277132 | 55943627 |
Blood creatinine increased | 79.61 | 9.91 | 253 | 71055 | 79938 | 56140821 |
Helicobacter infection | 76.29 | 9.91 | 4 | 71304 | 73264 | 56147495 |
Pyrexia | 75.85 | 9.91 | 837 | 70471 | 417936 | 55802823 |
Febrile bone marrow aplasia | 74.88 | 9.91 | 64 | 71244 | 6508 | 56214251 |
Nervous system disorder | 74.11 | 9.91 | 99 | 71209 | 16790 | 56203969 |
Pericarditis | 70.36 | 9.91 | 25 | 71283 | 108898 | 56111861 |
Intentional overdose | 70.05 | 9.91 | 4 | 71304 | 68113 | 56152646 |
Maternal exposure during pregnancy | 64.96 | 9.91 | 87 | 71221 | 189466 | 56031293 |
Discomfort | 64.50 | 9.91 | 51 | 71257 | 141710 | 56079049 |
Laryngitis fungal | 64.47 | 9.91 | 18 | 71290 | 129 | 56220630 |
Platelet count decreased | 63.38 | 9.91 | 285 | 71023 | 106098 | 56114661 |
Rheumatoid factor positive | 60.39 | 9.91 | 8 | 71300 | 69052 | 56151707 |
Acute generalised exanthematous pustulosis | 59.69 | 9.91 | 68 | 71240 | 9801 | 56210958 |
Drug abuse | 58.72 | 9.91 | 8 | 71300 | 67602 | 56153157 |
Diarrhoea | 58.44 | 9.91 | 1133 | 70175 | 637374 | 55583385 |
Rectal prolapse | 56.24 | 9.91 | 33 | 71275 | 1841 | 56218918 |
Muscle injury | 54.24 | 9.91 | 3 | 71305 | 52497 | 56168262 |
Depressed level of consciousness | 54.14 | 9.91 | 176 | 71132 | 56257 | 56164502 |
Injection site inflammation | 53.29 | 9.91 | 40 | 71268 | 3376 | 56217383 |
Tumour lysis syndrome | 52.05 | 9.91 | 57 | 71251 | 7866 | 56212893 |
Dermatitis exfoliative generalised | 51.04 | 9.91 | 39 | 71269 | 3381 | 56217378 |
Pain | 50.70 | 9.91 | 567 | 70741 | 662617 | 55558142 |
Product use issue | 49.22 | 9.91 | 101 | 71207 | 185940 | 56034819 |
Genital herpes | 49.09 | 9.91 | 29 | 71279 | 1638 | 56219121 |
Diffuse large B-cell lymphoma refractory | 47.90 | 9.91 | 25 | 71283 | 1107 | 56219652 |
Hallucination, visual | 47.56 | 9.91 | 82 | 71226 | 17386 | 56203373 |
Encephalitis cytomegalovirus | 47.43 | 9.91 | 20 | 71288 | 542 | 56220217 |
Lymphopenia | 47.33 | 9.91 | 80 | 71228 | 16694 | 56204065 |
Renal disorder | 46.99 | 9.91 | 111 | 71197 | 29494 | 56191265 |
Septic shock | 45.66 | 9.91 | 175 | 71133 | 60660 | 56160099 |
Aplasia | 43.67 | 9.91 | 38 | 71270 | 3958 | 56216801 |
Vocal cord dysfunction | 43.23 | 9.91 | 17 | 71291 | 383 | 56220376 |
Arthralgia | 43.14 | 9.91 | 417 | 70891 | 501252 | 55719507 |
Hepatic enzyme increased | 42.87 | 9.91 | 96 | 71212 | 171288 | 56049471 |
Musculoskeletal stiffness | 42.71 | 9.91 | 83 | 71225 | 155924 | 56064835 |
Impaired healing | 41.07 | 9.91 | 30 | 71278 | 86811 | 56133948 |
Mobility decreased | 40.90 | 9.91 | 39 | 71269 | 98952 | 56121807 |
Ophthalmic herpes simplex | 40.90 | 9.91 | 17 | 71291 | 444 | 56220315 |
Cholestasis | 40.66 | 9.91 | 99 | 71209 | 26814 | 56193945 |
Cytomegalovirus infection | 40.51 | 9.91 | 81 | 71227 | 19215 | 56201544 |
Folliculitis | 40.26 | 9.91 | 10 | 71298 | 54969 | 56165790 |
Immune effector cell-associated neurotoxicity syndrome | 39.73 | 9.91 | 25 | 71283 | 1583 | 56219176 |
Eosinophilia | 39.45 | 9.91 | 82 | 71226 | 19995 | 56200764 |
Hypersensitivity | 38.70 | 9.91 | 180 | 71128 | 256228 | 55964531 |
Bronchopulmonary aspergillosis | 38.66 | 9.91 | 50 | 71258 | 8214 | 56212545 |
Human herpesvirus 6 encephalitis | 38.58 | 9.91 | 13 | 71295 | 185 | 56220574 |
Acute myeloid leukaemia | 37.76 | 9.91 | 73 | 71235 | 16899 | 56203860 |
Lower respiratory tract infection | 36.03 | 9.91 | 56 | 71252 | 114738 | 56106021 |
Therapeutic product effect incomplete | 35.96 | 9.91 | 49 | 71259 | 105982 | 56114777 |
Delirium | 34.99 | 9.91 | 126 | 71182 | 42391 | 56178368 |
Toxicity to various agents | 34.27 | 9.91 | 157 | 71151 | 224407 | 55996352 |
Post herpetic neuralgia | 34.25 | 9.91 | 25 | 71283 | 2022 | 56218737 |
Graft versus host disease | 33.26 | 9.91 | 42 | 71266 | 6739 | 56214020 |
Bladder prolapse | 33.03 | 9.91 | 24 | 71284 | 1927 | 56218832 |
Suicide attempt | 32.94 | 9.91 | 16 | 71292 | 57820 | 56162939 |
Full blood count decreased | 32.24 | 9.91 | 83 | 71225 | 23266 | 56197493 |
Myoclonus | 32.13 | 9.91 | 64 | 71244 | 15139 | 56205620 |
Renal impairment | 31.92 | 9.91 | 193 | 71115 | 80520 | 56140239 |
Genital herpes simplex | 31.84 | 9.91 | 12 | 71296 | 240 | 56220519 |
Plasma cell myeloma recurrent | 31.57 | 9.91 | 27 | 71281 | 2747 | 56218012 |
Toxic erythema of chemotherapy | 30.29 | 9.91 | 10 | 71298 | 133 | 56220626 |
Infusion related reaction | 30.16 | 9.91 | 149 | 71159 | 208782 | 56011977 |
Urine output decreased | 29.88 | 9.91 | 51 | 71257 | 10726 | 56210033 |
Renal tubular disorder | 29.77 | 9.91 | 25 | 71283 | 2481 | 56218278 |
Fungal endocarditis | 29.14 | 9.91 | 11 | 71297 | 221 | 56220538 |
Irritable bowel syndrome | 28.24 | 9.91 | 27 | 71281 | 68431 | 56152328 |
Bacterial sepsis | 28.22 | 9.91 | 29 | 71279 | 3720 | 56217039 |
Ophthalmic herpes zoster | 28.18 | 9.91 | 21 | 71287 | 1753 | 56219006 |
Cerebellar stroke | 28.05 | 9.91 | 11 | 71297 | 246 | 56220513 |
Laboratory test abnormal | 27.36 | 9.91 | 81 | 71227 | 24614 | 56196145 |
Blood uric acid increased | 26.97 | 9.91 | 30 | 71278 | 4212 | 56216547 |
Hepatic cytolysis | 26.86 | 9.91 | 49 | 71259 | 10857 | 56209902 |
Cytopenia | 26.83 | 9.91 | 46 | 71262 | 9709 | 56211050 |
Neutrophil count decreased | 26.37 | 9.91 | 129 | 71179 | 49693 | 56171066 |
Sepsis | 26.34 | 9.91 | 282 | 71026 | 139558 | 56081201 |
Deep vein thrombosis | 26.08 | 9.91 | 177 | 71131 | 76800 | 56143959 |
Drug interaction | 25.66 | 9.91 | 158 | 71150 | 209597 | 56011162 |
Restlessness | 25.56 | 9.91 | 83 | 71225 | 26503 | 56194256 |
Psychiatric symptom | 25.35 | 9.91 | 31 | 71277 | 4813 | 56215946 |
Psoriatic arthropathy | 25.29 | 9.91 | 34 | 71274 | 73974 | 56146785 |
Lymphocyte count decreased | 24.88 | 9.91 | 85 | 71223 | 27854 | 56192905 |
Disorientation | 24.79 | 9.91 | 102 | 71206 | 36511 | 56184248 |
Laryngeal stenosis | 24.60 | 9.91 | 15 | 71293 | 898 | 56219861 |
Cytomegalovirus chorioretinitis | 24.55 | 9.91 | 19 | 71289 | 1679 | 56219080 |
C-reactive protein abnormal | 24.54 | 9.91 | 8 | 71300 | 36801 | 56183958 |
COVID-19 | 23.90 | 9.91 | 170 | 71138 | 74888 | 56145871 |
Pneumonia | 23.68 | 9.91 | 679 | 70629 | 406419 | 55814340 |
Posterior reversible encephalopathy syndrome | 23.35 | 9.91 | 58 | 71250 | 15902 | 56204857 |
Serotonin syndrome | 23.32 | 9.91 | 3 | 71305 | 26487 | 56194272 |
Infective aneurysm | 23.23 | 9.91 | 11 | 71297 | 394 | 56220365 |
Pathogen resistance | 23.06 | 9.91 | 33 | 71275 | 5967 | 56214792 |
Hip arthroplasty | 23.06 | 9.91 | 10 | 71298 | 38613 | 56182146 |
Hallucination | 23.03 | 9.91 | 123 | 71185 | 49026 | 56171733 |
Escherichia bacteraemia | 22.92 | 9.91 | 25 | 71283 | 3435 | 56217324 |
COVID-19 pneumonia | 22.58 | 9.91 | 46 | 71262 | 11056 | 56209703 |
Loss of personal independence in daily activities | 22.51 | 9.91 | 43 | 71265 | 81326 | 56139433 |
Eye infection bacterial | 22.38 | 9.91 | 8 | 71300 | 137 | 56220622 |
Decreased appetite | 22.32 | 9.91 | 396 | 70912 | 218835 | 56001924 |
Plasmacytoma | 22.14 | 9.91 | 21 | 71287 | 2445 | 56218314 |
Product tampering | 22.09 | 9.91 | 9 | 71299 | 223 | 56220536 |
Skin lesion | 21.98 | 9.91 | 82 | 71226 | 28053 | 56192706 |
Mixed liver injury | 21.89 | 9.91 | 26 | 71282 | 3918 | 56216841 |
Mucormycosis | 21.87 | 9.91 | 22 | 71286 | 2752 | 56218007 |
Neuropsychiatric syndrome | 21.87 | 9.91 | 6 | 71302 | 40 | 56220719 |
Intentional self-injury | 21.60 | 9.91 | 3 | 71305 | 24989 | 56195770 |
Terminal ileitis | 21.38 | 9.91 | 12 | 71296 | 615 | 56220144 |
Vitamin D decreased | 21.35 | 9.91 | 40 | 71268 | 9043 | 56211716 |
Biopsy skin abnormal | 21.28 | 9.91 | 7 | 71301 | 92 | 56220667 |
Squamous cell carcinoma of skin | 21.19 | 9.91 | 30 | 71278 | 5372 | 56215387 |
Spina bifida | 21.07 | 9.91 | 13 | 71295 | 795 | 56219964 |
Cerebral ventricle dilatation | 20.99 | 9.91 | 14 | 71294 | 979 | 56219780 |
Bicytopenia | 20.76 | 9.91 | 19 | 71289 | 2114 | 56218645 |
Congenital herpes simplex infection | 20.46 | 9.91 | 4 | 71304 | 3 | 56220756 |
Metabolic encephalopathy | 20.23 | 9.91 | 29 | 71279 | 5251 | 56215508 |
Knee arthroplasty | 20.01 | 9.91 | 16 | 71292 | 44243 | 56176516 |
Mucosal excoriation | 19.92 | 9.91 | 4 | 71304 | 4 | 56220755 |
Pneumocystis jirovecii pneumonia | 19.83 | 9.91 | 54 | 71254 | 15647 | 56205112 |
Meningoencephalitis herpetic | 19.65 | 9.91 | 14 | 71294 | 1090 | 56219669 |
Red blood cell sedimentation rate increased | 19.57 | 9.91 | 11 | 71297 | 36612 | 56184147 |
Bacterial vaginosis | 19.34 | 9.91 | 14 | 71294 | 1118 | 56219641 |
Cryptosporidiosis infection | 19.23 | 9.91 | 9 | 71299 | 314 | 56220445 |
Liver injury | 19.08 | 9.91 | 15 | 71293 | 41833 | 56178926 |
Bone marrow necrosis | 18.81 | 9.91 | 6 | 71302 | 71 | 56220688 |
Dyspnoea | 18.51 | 9.91 | 591 | 70717 | 591986 | 55628773 |
Campylobacter colitis | 18.40 | 9.91 | 5 | 71303 | 32 | 56220727 |
Bradycardia | 18.38 | 9.91 | 36 | 71272 | 67468 | 56153291 |
Speech disorder | 18.37 | 9.91 | 95 | 71213 | 37398 | 56183361 |
Anaphylactic reaction | 18.30 | 9.91 | 29 | 71279 | 58966 | 56161793 |
Gastrointestinal disorder | 18.26 | 9.91 | 77 | 71231 | 112625 | 56108134 |
Foreign body in reproductive tract | 18.19 | 9.91 | 10 | 71298 | 492 | 56220267 |
Vitiligo | 18.16 | 9.91 | 14 | 71294 | 1230 | 56219529 |
Ectropion | 18.08 | 9.91 | 7 | 71301 | 151 | 56220608 |
Epstein-Barr virus associated lymphoma | 17.95 | 9.91 | 10 | 71298 | 505 | 56220254 |
Dermo-hypodermitis | 17.88 | 9.91 | 8 | 71300 | 251 | 56220508 |
Sedation | 17.87 | 9.91 | 11 | 71297 | 34843 | 56185916 |
Cell death | 17.57 | 9.91 | 18 | 71290 | 2301 | 56218458 |
Neurological symptom | 17.55 | 9.91 | 26 | 71282 | 4850 | 56215909 |
Drug monitoring procedure not performed | 17.47 | 9.91 | 10 | 71298 | 532 | 56220227 |
International normalised ratio increased | 17.44 | 9.91 | 18 | 71290 | 44023 | 56176736 |
Acute pulmonary oedema | 17.29 | 9.91 | 33 | 71275 | 7564 | 56213195 |
Congenital pyelocaliectasis | 17.02 | 9.91 | 3 | 71305 | 0 | 56220759 |
Sopor | 16.97 | 9.91 | 3 | 71305 | 20919 | 56199840 |
Soliloquy | 16.73 | 9.91 | 7 | 71301 | 186 | 56220573 |
Mycetoma mycotic | 16.69 | 9.91 | 4 | 71304 | 14 | 56220745 |
Pseudolymphoma | 16.65 | 9.91 | 10 | 71298 | 582 | 56220177 |
Tractional retinal detachment | 16.62 | 9.91 | 5 | 71303 | 48 | 56220711 |
Herpes ophthalmic | 16.54 | 9.91 | 13 | 71295 | 1175 | 56219584 |
Asthma | 16.50 | 9.91 | 80 | 71228 | 112690 | 56108069 |
Hyperthermia | 16.47 | 9.91 | 34 | 71274 | 8251 | 56212508 |
Infective chondritis | 16.27 | 9.91 | 4 | 71304 | 16 | 56220743 |
Hepatitis acute | 16.26 | 9.91 | 34 | 71274 | 8323 | 56212436 |
Confusional state | 16.15 | 9.91 | 361 | 70947 | 207794 | 56012965 |
Portal vein cavernous transformation | 16.01 | 9.91 | 6 | 71302 | 118 | 56220641 |
Pseudomyopia | 16.01 | 9.91 | 5 | 71303 | 55 | 56220704 |
Hypoglycaemic seizure | 15.99 | 9.91 | 9 | 71299 | 464 | 56220295 |
Cholecystitis chronic | 15.96 | 9.91 | 37 | 71271 | 9711 | 56211048 |
Chronic papillomatous dermatitis | 15.93 | 9.91 | 5 | 71303 | 56 | 56220703 |
Metastases to liver | 15.66 | 9.91 | 4 | 71304 | 21582 | 56199177 |
Chronic lymphocytic leukaemia | 15.44 | 9.91 | 19 | 71289 | 2969 | 56217790 |
Laryngeal inflammation | 15.43 | 9.91 | 6 | 71302 | 131 | 56220628 |
Central nervous system necrosis | 15.35 | 9.91 | 6 | 71302 | 133 | 56220626 |
Accidental exposure to product | 15.33 | 9.91 | 6 | 71302 | 24641 | 56196118 |
Epstein-Barr virus infection | 15.27 | 9.91 | 31 | 71277 | 7432 | 56213327 |
Aspergillus infection | 15.27 | 9.91 | 31 | 71277 | 7434 | 56213325 |
Thermal burn | 15.26 | 9.91 | 26 | 71282 | 5459 | 56215300 |
Hepatitis E | 15.12 | 9.91 | 13 | 71295 | 1332 | 56219427 |
Neurosis | 14.99 | 9.91 | 7 | 71301 | 243 | 56220516 |
Imperception | 14.94 | 9.91 | 3 | 71305 | 3 | 56220756 |
Citrobacter sepsis | 14.94 | 9.91 | 3 | 71305 | 3 | 56220756 |
Nausea | 14.82 | 9.91 | 1141 | 70167 | 763037 | 55457722 |
Blood pressure systolic abnormal | 14.80 | 9.91 | 36 | 71272 | 9741 | 56211018 |
Renal failure | 14.79 | 9.91 | 209 | 71099 | 110291 | 56110468 |
Rhabdomyolysis | 14.59 | 9.91 | 18 | 71290 | 40640 | 56180119 |
Limbic encephalitis | 14.55 | 9.91 | 7 | 71301 | 260 | 56220499 |
Feeling abnormal | 14.55 | 9.91 | 244 | 71064 | 133358 | 56087401 |
Cryopyrin associated periodic syndrome | 14.49 | 9.91 | 6 | 71302 | 155 | 56220604 |
Constipation | 14.36 | 9.91 | 346 | 70962 | 201597 | 56019162 |
Venoocclusive disease | 14.36 | 9.91 | 15 | 71293 | 1962 | 56218797 |
Hepatitis | 14.16 | 9.91 | 85 | 71223 | 35356 | 56185403 |
Gamma-glutamyltransferase increased | 14.12 | 9.91 | 77 | 71231 | 30928 | 56189831 |
Human ehrlichiosis | 14.11 | 9.91 | 6 | 71302 | 166 | 56220593 |
Eye infection toxoplasmal | 14.07 | 9.91 | 7 | 71301 | 280 | 56220479 |
Lichenification | 14.06 | 9.91 | 8 | 71300 | 421 | 56220338 |
CSF cell count increased | 14.05 | 9.91 | 4 | 71304 | 31 | 56220728 |
Pain in extremity | 14.02 | 9.91 | 279 | 71029 | 297152 | 55923607 |
Peripheral swelling | 14.02 | 9.91 | 211 | 71097 | 234515 | 55986244 |
Mycobacterial peritonitis | 13.86 | 9.91 | 5 | 71303 | 88 | 56220671 |
Blister | 13.84 | 9.91 | 81 | 71227 | 108806 | 56111953 |
Embedded device | 13.83 | 9.91 | 18 | 71290 | 2975 | 56217784 |
Antiviral drug level above therapeutic | 13.73 | 9.91 | 3 | 71305 | 6 | 56220753 |
Meningocele | 13.73 | 9.91 | 3 | 71305 | 6 | 56220753 |
Pyelitis | 13.69 | 9.91 | 6 | 71302 | 179 | 56220580 |
Disseminated varicella zoster virus infection | 13.66 | 9.91 | 6 | 71302 | 180 | 56220579 |
Type 2 diabetes mellitus | 13.64 | 9.91 | 24 | 71284 | 46838 | 56173921 |
Cardiac failure congestive | 13.55 | 9.91 | 61 | 71247 | 87659 | 56133100 |
Hepatitis cholestatic | 13.55 | 9.91 | 27 | 71281 | 6387 | 56214372 |
Pharyngeal inflammation | 13.54 | 9.91 | 9 | 71299 | 626 | 56220133 |
Seasonal allergy | 13.48 | 9.91 | 50 | 71258 | 17058 | 56203701 |
Bone marrow failure | 13.39 | 9.91 | 71 | 71237 | 28215 | 56192544 |
Dermatitis exfoliative | 13.29 | 9.91 | 24 | 71284 | 5275 | 56215484 |
Inappropriate antidiuretic hormone secretion | 13.27 | 9.91 | 43 | 71265 | 13713 | 56207046 |
Leukaemia recurrent | 13.26 | 9.91 | 12 | 71296 | 1316 | 56219443 |
Vision blurred | 13.24 | 9.91 | 162 | 71146 | 82781 | 56137978 |
Psychiatric decompensation | 13.18 | 9.91 | 12 | 71296 | 1326 | 56219433 |
Neuralgia | 13.00 | 9.91 | 62 | 71246 | 23633 | 56197126 |
Rhegmatogenous retinal detachment | 13.00 | 9.91 | 5 | 71303 | 106 | 56220653 |
Coronary artery disease | 12.87 | 9.91 | 12 | 71296 | 30784 | 56189975 |
Rash pustular | 12.84 | 9.91 | 27 | 71281 | 6636 | 56214123 |
Musculoskeletal pain | 12.80 | 9.91 | 56 | 71252 | 81096 | 56139663 |
Cardiac arrest | 12.76 | 9.91 | 61 | 71247 | 86253 | 56134506 |
Blood lactate dehydrogenase increased | 12.76 | 9.91 | 56 | 71252 | 20619 | 56200140 |
Pulmonary arterial hypertension | 12.73 | 9.91 | 9 | 71299 | 26494 | 56194265 |
Autoimmune nephritis | 12.68 | 9.91 | 7 | 71301 | 347 | 56220412 |
Graft versus host disease in gastrointestinal tract | 12.54 | 9.91 | 17 | 71291 | 2922 | 56217837 |
Tri-iodothyronine free increased | 12.54 | 9.91 | 6 | 71302 | 220 | 56220539 |
Condition aggravated | 12.48 | 9.91 | 337 | 70971 | 344561 | 55876198 |
Subacute combined cord degeneration | 12.44 | 9.91 | 6 | 71302 | 224 | 56220535 |
Cardiomyopathy acute | 12.37 | 9.91 | 6 | 71302 | 227 | 56220532 |
Kussmaul respiration | 12.34 | 9.91 | 6 | 71302 | 228 | 56220531 |
Osteoarthritis | 12.31 | 9.91 | 56 | 71252 | 80240 | 56140519 |
Aminoaciduria | 12.23 | 9.91 | 5 | 71303 | 125 | 56220634 |
Thrombosis | 12.20 | 9.91 | 122 | 71186 | 59305 | 56161454 |
Contusion | 12.18 | 9.91 | 104 | 71204 | 128326 | 56092433 |
Fibromyalgia | 12.12 | 9.91 | 37 | 71271 | 59566 | 56161193 |
Blood cholesterol increased | 12.12 | 9.91 | 49 | 71259 | 72530 | 56148229 |
Progressive multifocal leukoencephalopathy | 12.00 | 9.91 | 38 | 71270 | 11975 | 56208784 |
Acute febrile neutrophilic dermatosis | 11.99 | 9.91 | 16 | 71292 | 2709 | 56218050 |
Streptococcal bacteraemia | 11.97 | 9.91 | 12 | 71296 | 1495 | 56219264 |
Hepatic cirrhosis | 11.93 | 9.91 | 6 | 71302 | 21257 | 56199502 |
Tandem gait test abnormal | 11.83 | 9.91 | 3 | 71305 | 14 | 56220745 |
Acute respiratory distress syndrome | 11.76 | 9.91 | 57 | 71251 | 21869 | 56198890 |
Angina bullosa haemorrhagica | 11.74 | 9.91 | 5 | 71303 | 139 | 56220620 |
Rash vesicular | 11.74 | 9.91 | 19 | 71289 | 3826 | 56216933 |
Escherichia pyelonephritis | 11.73 | 9.91 | 7 | 71301 | 403 | 56220356 |
Metastases to bone | 11.73 | 9.91 | 5 | 71303 | 19503 | 56201256 |
Nystagmus | 11.69 | 9.91 | 24 | 71284 | 5801 | 56214958 |
Oliguria | 11.65 | 9.91 | 30 | 71278 | 8410 | 56212349 |
Dizziness | 11.60 | 9.91 | 585 | 70723 | 375555 | 55845204 |
Incoherent | 11.57 | 9.91 | 20 | 71288 | 4249 | 56216510 |
Anal infection | 11.56 | 9.91 | 4 | 71304 | 62 | 56220697 |
Death | 11.48 | 9.91 | 337 | 70971 | 341089 | 55879670 |
Tumour flare | 11.45 | 9.91 | 6 | 71302 | 268 | 56220491 |
Lymphocyte morphology abnormal | 11.43 | 9.91 | 7 | 71301 | 422 | 56220337 |
Cerebral thrombosis | 11.43 | 9.91 | 12 | 71296 | 1578 | 56219181 |
Hypouricaemia | 11.41 | 9.91 | 5 | 71303 | 149 | 56220610 |
Hemianopia homonymous | 11.41 | 9.91 | 8 | 71300 | 607 | 56220152 |
Hypophagia | 11.38 | 9.91 | 69 | 71239 | 28807 | 56191952 |
Unevaluable event | 11.33 | 9.91 | 101 | 71207 | 47586 | 56173173 |
Therapeutic response decreased | 11.27 | 9.91 | 32 | 71276 | 52726 | 56168033 |
Pneumocystis jirovecii infection | 11.24 | 9.91 | 11 | 71297 | 1331 | 56219428 |
Visual acuity reduced | 11.20 | 9.91 | 54 | 71254 | 20672 | 56200087 |
Haemophagocytic lymphohistiocytosis | 11.18 | 9.91 | 32 | 71276 | 9540 | 56211219 |
Cholestatic liver injury | 11.13 | 9.91 | 14 | 71294 | 2238 | 56218521 |
Varicella zoster virus infection | 11.11 | 9.91 | 15 | 71293 | 2569 | 56218190 |
Scab | 11.09 | 9.91 | 26 | 71282 | 6872 | 56213887 |
Monocyte percentage increased | 11.08 | 9.91 | 10 | 71298 | 1093 | 56219666 |
Haemorrhagic occlusive retinal vasculitis | 11.07 | 9.91 | 3 | 71305 | 19 | 56220740 |
Emotional distress | 11.02 | 9.91 | 70 | 71238 | 29693 | 56191066 |
Adulterated product | 10.95 | 9.91 | 4 | 71304 | 73 | 56220686 |
Coordination abnormal | 10.89 | 9.91 | 38 | 71270 | 12583 | 56208176 |
Thrombotic thrombocytopenic purpura | 10.85 | 9.91 | 18 | 71290 | 3699 | 56217060 |
Nephritis | 10.85 | 9.91 | 14 | 71294 | 2295 | 56218464 |
Limb injury | 10.61 | 9.91 | 56 | 71252 | 22214 | 56198545 |
Macrocytosis | 10.58 | 9.91 | 14 | 71294 | 2352 | 56218407 |
Pancreatitis acute | 10.52 | 9.91 | 61 | 71247 | 25063 | 56195696 |
Gastrointestinal haemorrhage | 10.47 | 9.91 | 55 | 71253 | 75896 | 56144863 |
Joint range of motion decreased | 10.46 | 9.91 | 10 | 71298 | 25355 | 56195404 |
Asterixis | 10.35 | 9.91 | 10 | 71298 | 1191 | 56219568 |
Somatic symptom disorder | 10.31 | 9.91 | 13 | 71295 | 2082 | 56218677 |
Chills | 10.30 | 9.91 | 185 | 71123 | 102419 | 56118340 |
Acute myopia | 10.30 | 9.91 | 4 | 71304 | 87 | 56220672 |
Hyperuricaemia | 10.30 | 9.91 | 21 | 71287 | 5052 | 56215707 |
Cytomegalovirus colitis | 10.28 | 9.91 | 13 | 71295 | 2089 | 56218670 |
Product substitution issue | 10.14 | 9.91 | 41 | 71267 | 14558 | 56206201 |
Tympanic membrane perforation | 10.13 | 9.91 | 12 | 71296 | 1803 | 56218956 |
Disseminated cytomegaloviral infection | 10.10 | 9.91 | 5 | 71303 | 198 | 56220561 |
Cytomegalovirus test positive | 10.07 | 9.91 | 15 | 71293 | 2811 | 56217948 |
Chronic obstructive pulmonary disease | 10.07 | 9.91 | 38 | 71270 | 57377 | 56163382 |
Erythema annulare | 10.02 | 9.91 | 4 | 71304 | 94 | 56220665 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 345.45 | 10.80 | 686 | 53121 | 121163 | 31522374 |
Cytokine release syndrome | 218.01 | 10.80 | 199 | 53608 | 16443 | 31627094 |
Neutropenia | 178.04 | 10.80 | 583 | 53224 | 139781 | 31503756 |
Neurotoxicity | 176.32 | 10.80 | 175 | 53632 | 16051 | 31627486 |
Plasma cell myeloma | 167.91 | 10.80 | 325 | 53482 | 56206 | 31587331 |
Pyrexia | 159.75 | 10.80 | 969 | 52838 | 302871 | 31340666 |
Thrombocytopenia | 150.68 | 10.80 | 558 | 53249 | 142189 | 31501348 |
Encephalopathy | 146.85 | 10.80 | 225 | 53582 | 32249 | 31611288 |
Acute generalised exanthematous pustulosis | 138.09 | 10.80 | 100 | 53707 | 5940 | 31637597 |
Herpes zoster | 134.00 | 10.80 | 214 | 53593 | 31779 | 31611758 |
Completed suicide | 130.03 | 10.80 | 6 | 53801 | 91508 | 31552029 |
Febrile bone marrow aplasia | 125.20 | 10.80 | 105 | 53702 | 7741 | 31635796 |
Drug reaction with eosinophilia and systemic symptoms | 124.63 | 10.80 | 200 | 53607 | 29818 | 31613719 |
Drug abuse | 120.75 | 10.80 | 7 | 53800 | 87751 | 31555786 |
Agranulocytosis | 120.59 | 10.80 | 164 | 53643 | 21083 | 31622454 |
Toxic encephalopathy | 110.19 | 10.80 | 80 | 53727 | 4770 | 31638767 |
Hepatocellular injury | 105.55 | 10.80 | 155 | 53652 | 21389 | 31622148 |
Acute kidney injury | 102.86 | 10.80 | 818 | 52989 | 278896 | 31364641 |
Toxicity to various agents | 101.74 | 10.80 | 95 | 53712 | 181392 | 31462145 |
Rash maculo-papular | 99.51 | 10.80 | 166 | 53641 | 25553 | 31617984 |
Pancytopenia | 97.61 | 10.80 | 348 | 53459 | 86968 | 31556569 |
Toxic skin eruption | 92.90 | 10.80 | 100 | 53707 | 10080 | 31633457 |
Neuropathy peripheral | 88.41 | 10.80 | 306 | 53501 | 75343 | 31568194 |
Dyslalia | 87.09 | 10.80 | 33 | 53774 | 492 | 31643045 |
Altered state of consciousness | 82.94 | 10.80 | 137 | 53670 | 20914 | 31622623 |
Dysarthria | 78.34 | 10.80 | 170 | 53637 | 31847 | 31611690 |
Nervous system disorder | 77.72 | 10.80 | 104 | 53703 | 13159 | 31630378 |
Ophthalmic herpes simplex | 76.18 | 10.80 | 26 | 53781 | 281 | 31643256 |
Dermatitis exfoliative generalised | 75.49 | 10.80 | 54 | 53753 | 3145 | 31640392 |
Pneumonia | 75.29 | 10.80 | 884 | 52923 | 334428 | 31309109 |
Drug ineffective | 72.54 | 10.80 | 386 | 53421 | 395187 | 31248350 |
Bronchopulmonary aspergillosis | 71.01 | 10.80 | 101 | 53706 | 13533 | 31630004 |
Microsporidia infection | 67.69 | 10.80 | 29 | 53778 | 603 | 31642934 |
White blood cell count decreased | 67.05 | 10.80 | 310 | 53497 | 87088 | 31556449 |
Squamous cell carcinoma of skin | 63.04 | 10.80 | 82 | 53725 | 10092 | 31633445 |
Drug interaction | 62.62 | 10.80 | 166 | 53641 | 208377 | 31435160 |
Cholestasis | 60.03 | 10.80 | 132 | 53675 | 24943 | 31618594 |
Cytopenia | 57.98 | 10.80 | 82 | 53725 | 10928 | 31632609 |
Tumour lysis syndrome | 57.76 | 10.80 | 98 | 53709 | 15287 | 31628250 |
Cerebral toxoplasmosis | 57.66 | 10.80 | 35 | 53772 | 1542 | 31641995 |
Hepatic cytolysis | 57.58 | 10.80 | 81 | 53726 | 10742 | 31632795 |
Demodicidosis | 47.42 | 10.80 | 15 | 53792 | 125 | 31643412 |
Pathogen resistance | 46.11 | 10.80 | 65 | 53742 | 8636 | 31634901 |
Face oedema | 45.78 | 10.80 | 72 | 53735 | 10544 | 31632993 |
Intentional overdose | 44.91 | 10.80 | 8 | 53799 | 41381 | 31602156 |
COVID-19 | 43.90 | 10.80 | 197 | 53610 | 54624 | 31588913 |
Chronic lymphocytic leukaemia | 43.39 | 10.80 | 47 | 53760 | 4769 | 31638768 |
Platelet count decreased | 43.14 | 10.80 | 328 | 53479 | 110107 | 31533430 |
Suicide attempt | 43.13 | 10.80 | 6 | 53801 | 37242 | 31606295 |
Hypoglycaemia | 40.27 | 10.80 | 18 | 53789 | 50928 | 31592609 |
Genital herpes | 40.23 | 10.80 | 20 | 53787 | 591 | 31642946 |
Acute myeloid leukaemia | 38.84 | 10.80 | 93 | 53714 | 18579 | 31624958 |
Dyspnoea | 38.22 | 10.80 | 386 | 53421 | 343093 | 31300444 |
Pseudomonas infection | 38.09 | 10.80 | 69 | 53738 | 11332 | 31632205 |
Nephritis allergic | 37.95 | 10.80 | 17 | 53790 | 395 | 31643142 |
Graft versus host disease | 37.18 | 10.80 | 65 | 53742 | 10382 | 31633155 |
Aplasia | 36.10 | 10.80 | 40 | 53767 | 4163 | 31639374 |
Intentional product misuse | 35.82 | 10.80 | 10 | 53797 | 37941 | 31605596 |
Lung disorder | 35.37 | 10.80 | 128 | 53679 | 32184 | 31611353 |
Herpes simplex | 35.22 | 10.80 | 44 | 53763 | 5201 | 31638336 |
Thrombotic microangiopathy | 34.35 | 10.80 | 59 | 53748 | 9292 | 31634245 |
Septic shock | 33.83 | 10.80 | 210 | 53597 | 65948 | 31577589 |
Graft versus host disease in gastrointestinal tract | 33.19 | 10.80 | 35 | 53772 | 3444 | 31640093 |
Bradycardia | 32.46 | 10.80 | 42 | 53765 | 69285 | 31574252 |
Eosinophilia | 31.54 | 10.80 | 99 | 53708 | 23154 | 31620383 |
Depression | 30.57 | 10.80 | 68 | 53739 | 90747 | 31552790 |
Pulmonary sarcoidosis | 30.42 | 10.80 | 16 | 53791 | 533 | 31643004 |
International normalised ratio increased | 29.90 | 10.80 | 20 | 53787 | 45203 | 31598334 |
Congenital herpes simplex infection | 29.65 | 10.80 | 8 | 53799 | 35 | 31643502 |
Parainfluenzae virus infection | 29.57 | 10.80 | 28 | 53779 | 2421 | 31641116 |
Differentiation syndrome | 29.49 | 10.80 | 21 | 53786 | 1214 | 31642323 |
Confusional state | 29.49 | 10.80 | 351 | 53456 | 132983 | 31510554 |
Lymphopenia | 29.40 | 10.80 | 71 | 53736 | 14258 | 31629279 |
Purpura | 29.40 | 10.80 | 56 | 53751 | 9554 | 31633983 |
Pericarditis | 29.38 | 10.80 | 55 | 53752 | 9261 | 31634276 |
Drug hypersensitivity | 28.18 | 10.80 | 50 | 53757 | 72549 | 31570988 |
Neutrophil count decreased | 28.08 | 10.80 | 154 | 53653 | 46240 | 31597297 |
Mucosal inflammation | 27.76 | 10.80 | 124 | 53683 | 34303 | 31609234 |
Wrong technique in product usage process | 27.60 | 10.80 | 11 | 53796 | 33332 | 31610205 |
Squamous cell carcinoma | 27.48 | 10.80 | 58 | 53749 | 10653 | 31632884 |
Rhabdomyolysis | 27.29 | 10.80 | 41 | 53766 | 63540 | 31579997 |
Inappropriate schedule of product administration | 26.80 | 10.80 | 28 | 53779 | 50795 | 31592742 |
Eosinophilic colitis | 26.59 | 10.80 | 11 | 53796 | 209 | 31643328 |
Plasma cell myeloma recurrent | 26.48 | 10.80 | 33 | 53774 | 3891 | 31639646 |
Encephalitis | 26.36 | 10.80 | 44 | 53763 | 6771 | 31636766 |
Rash | 26.26 | 10.80 | 484 | 53323 | 201002 | 31442535 |
Conjunctival irritation | 26.15 | 10.80 | 9 | 53798 | 100 | 31643437 |
Drug resistance | 25.74 | 10.80 | 93 | 53714 | 23360 | 31620177 |
Infective exacerbation of chronic obstructive airways disease | 25.49 | 10.80 | 22 | 53785 | 1686 | 31641851 |
Delirium | 25.41 | 10.80 | 138 | 53669 | 41283 | 31602254 |
Death | 25.16 | 10.80 | 446 | 53361 | 360123 | 31283414 |
Rhinovirus infection | 24.49 | 10.80 | 30 | 53777 | 3475 | 31640062 |
Varicella zoster virus infection | 24.49 | 10.80 | 21 | 53786 | 1595 | 31641942 |
Aggression | 23.97 | 10.80 | 17 | 53790 | 37274 | 31606263 |
Myocardial infarction | 23.97 | 10.80 | 105 | 53702 | 113349 | 31530188 |
Immune effector cell-associated neurotoxicity syndrome | 23.76 | 10.80 | 25 | 53782 | 2454 | 31641083 |
Hyperuricaemia | 23.57 | 10.80 | 44 | 53763 | 7394 | 31636143 |
Hallucination | 23.52 | 10.80 | 147 | 53660 | 46263 | 31597274 |
Escherichia sepsis | 23.38 | 10.80 | 32 | 53775 | 4135 | 31639402 |
Drug dependence | 23.16 | 10.80 | 5 | 53802 | 22574 | 31620963 |
Pain | 22.77 | 10.80 | 205 | 53602 | 186554 | 31456983 |
Stress | 22.75 | 10.80 | 7 | 53800 | 24934 | 31618603 |
Psychiatric symptom | 22.59 | 10.80 | 28 | 53779 | 3283 | 31640254 |
Anxiety | 22.58 | 10.80 | 79 | 53728 | 90954 | 31552583 |
Ichthyosis | 22.54 | 10.80 | 8 | 53799 | 98 | 31643439 |
Cardiac arrest | 22.28 | 10.80 | 77 | 53730 | 88985 | 31554552 |
Human herpesvirus 6 encephalitis | 22.06 | 10.80 | 10 | 53797 | 239 | 31643298 |
Full blood count decreased | 22.04 | 10.80 | 70 | 53737 | 16470 | 31627067 |
Injection site pain | 21.99 | 10.80 | 16 | 53791 | 34618 | 31608919 |
Blood pressure increased | 21.91 | 10.80 | 66 | 53741 | 79567 | 31563970 |
Bronchopneumopathy | 21.82 | 10.80 | 12 | 53795 | 438 | 31643099 |
Drug withdrawal syndrome | 21.75 | 10.80 | 3 | 53804 | 18747 | 31624790 |
Genital erythema | 21.33 | 10.80 | 9 | 53798 | 180 | 31643357 |
Hyperleukocytosis | 21.32 | 10.80 | 20 | 53787 | 1709 | 31641828 |
Respiratory tract infection | 21.32 | 10.80 | 72 | 53735 | 17489 | 31626048 |
Nocardiosis | 21.31 | 10.80 | 28 | 53779 | 3479 | 31640058 |
Respiratory arrest | 21.19 | 10.80 | 9 | 53798 | 26248 | 31617289 |
Ophthalmic herpes zoster | 21.17 | 10.80 | 15 | 53792 | 860 | 31642677 |
Angina pectoris | 21.13 | 10.80 | 12 | 53795 | 29629 | 31613908 |
Hepatitis cholestatic | 21.07 | 10.80 | 41 | 53766 | 7105 | 31636432 |
Botryomycosis | 20.96 | 10.80 | 6 | 53801 | 34 | 31643503 |
Blood creatinine abnormal | 20.80 | 10.80 | 22 | 53785 | 2172 | 31641365 |
Hypogammaglobulinaemia | 20.74 | 10.80 | 39 | 53768 | 6588 | 31636949 |
Tumour flare | 20.71 | 10.80 | 14 | 53793 | 744 | 31642793 |
Hallucination, visual | 20.28 | 10.80 | 66 | 53741 | 15728 | 31627809 |
Hypercalcaemia | 20.28 | 10.80 | 61 | 53746 | 13939 | 31629598 |
Malignant neoplasm of unknown primary site | 20.26 | 10.80 | 11 | 53796 | 391 | 31643146 |
Diffuse large B-cell lymphoma | 20.12 | 10.80 | 45 | 53762 | 8596 | 31634941 |
Respiratory tract infection bacterial | 20.11 | 10.80 | 18 | 53789 | 1448 | 31642089 |
Infection | 19.57 | 10.80 | 219 | 53588 | 81712 | 31561825 |
Malignant neoplasm progression | 19.29 | 10.80 | 69 | 53738 | 78929 | 31564608 |
Escherichia infection | 19.26 | 10.80 | 40 | 53767 | 7264 | 31636273 |
JC virus infection | 18.92 | 10.80 | 20 | 53787 | 1974 | 31641563 |
Glomerulosclerosis | 18.80 | 10.80 | 13 | 53794 | 717 | 31642820 |
Polymyositis | 18.67 | 10.80 | 17 | 53790 | 1398 | 31642139 |
Influenza | 18.61 | 10.80 | 134 | 53673 | 44191 | 31599346 |
Hyperhidrosis | 18.43 | 10.80 | 56 | 53751 | 67337 | 31576200 |
Musculoskeletal stiffness | 18.36 | 10.80 | 26 | 53781 | 41299 | 31602238 |
Atrial fibrillation | 18.33 | 10.80 | 283 | 53524 | 113500 | 31530037 |
Escherichia bacteraemia | 18.30 | 10.80 | 24 | 53783 | 2977 | 31640560 |
Aplastic anaemia | 18.24 | 10.80 | 45 | 53762 | 9158 | 31634379 |
Logorrhoea | 18.10 | 10.80 | 21 | 53786 | 2298 | 31641239 |
Laryngeal cancer metastatic | 18.09 | 10.80 | 6 | 53801 | 59 | 31643478 |
Monoclonal immunoglobulin present | 18.08 | 10.80 | 14 | 53793 | 920 | 31642617 |
Morganella infection | 18.03 | 10.80 | 11 | 53796 | 489 | 31643048 |
Mixed liver injury | 17.97 | 10.80 | 21 | 53786 | 2316 | 31641221 |
Herpes ophthalmic | 17.89 | 10.80 | 11 | 53796 | 496 | 31643041 |
Lymphocytic infiltration | 17.86 | 10.80 | 12 | 53795 | 631 | 31642906 |
Toxic neuropathy | 17.81 | 10.80 | 11 | 53796 | 500 | 31643037 |
Haemorrhoids thrombosed | 17.77 | 10.80 | 8 | 53799 | 188 | 31643349 |
Coronary artery disease | 17.65 | 10.80 | 32 | 53775 | 46055 | 31597482 |
Rheumatoid arthritis | 17.60 | 10.80 | 34 | 53773 | 47775 | 31595762 |
Bacillus bacteraemia | 17.57 | 10.80 | 6 | 53801 | 65 | 31643472 |
Acute HIV infection | 17.49 | 10.80 | 6 | 53801 | 66 | 31643471 |
SARS-CoV-2 sepsis | 17.42 | 10.80 | 7 | 53800 | 123 | 31643414 |
Brief psychotic disorder with marked stressors | 17.17 | 10.80 | 8 | 53799 | 204 | 31643333 |
Positive end-expiratory pressure | 17.14 | 10.80 | 4 | 53803 | 8 | 31643529 |
Blood creatine phosphokinase increased | 17.12 | 10.80 | 28 | 53779 | 41946 | 31601591 |
Pneumonia fungal | 17.09 | 10.80 | 35 | 53772 | 6294 | 31637243 |
Therapeutic product effect incomplete | 17.04 | 10.80 | 30 | 53777 | 43666 | 31599871 |
Respiratory tract infection viral | 17.01 | 10.80 | 19 | 53788 | 1995 | 31641542 |
Hyperbilirubinaemia | 16.90 | 10.80 | 62 | 53745 | 15688 | 31627849 |
Hyperthermia | 16.83 | 10.80 | 46 | 53761 | 9958 | 31633579 |
Vaccination failure | 16.73 | 10.80 | 13 | 53794 | 859 | 31642678 |
Dyscalculia | 16.72 | 10.80 | 6 | 53801 | 76 | 31643461 |
Myositis | 16.70 | 10.80 | 49 | 53758 | 11045 | 31632492 |
Viral mutation identified | 16.66 | 10.80 | 22 | 53785 | 2747 | 31640790 |
Incorrect disposal of product | 16.60 | 10.80 | 9 | 53798 | 319 | 31643218 |
Basal cell carcinoma | 16.60 | 10.80 | 68 | 53739 | 18111 | 31625426 |
Aspergillus infection | 16.48 | 10.80 | 50 | 53757 | 11478 | 31632059 |
CSF cell count increased | 16.44 | 10.80 | 5 | 53802 | 36 | 31643501 |
Lymphocyte count decreased | 16.36 | 10.80 | 74 | 53733 | 20575 | 31622962 |
Periorbital cellulitis | 16.26 | 10.80 | 8 | 53799 | 231 | 31643306 |
Fluid imbalance | 16.16 | 10.80 | 8 | 53799 | 234 | 31643303 |
Herpes virus infection | 16.00 | 10.80 | 21 | 53786 | 2606 | 31640931 |
Mutism | 15.86 | 10.80 | 12 | 53795 | 762 | 31642775 |
Stomatitis | 15.85 | 10.80 | 118 | 53689 | 39320 | 31604217 |
Citrobacter infection | 15.79 | 10.80 | 10 | 53797 | 475 | 31643062 |
Chest pain | 15.76 | 10.80 | 125 | 53682 | 116832 | 31526705 |
Acute myocardial infarction | 15.55 | 10.80 | 40 | 53767 | 50783 | 31592754 |
Disseminated cryptococcosis | 15.38 | 10.80 | 15 | 53792 | 1345 | 31642192 |
Hypercapnic coma | 15.34 | 10.80 | 7 | 53800 | 170 | 31643367 |
Renal disorder | 15.33 | 10.80 | 80 | 53727 | 23565 | 31619972 |
Respiratory depression | 15.32 | 10.80 | 3 | 53804 | 14507 | 31629030 |
Complications of transplanted heart | 15.31 | 10.80 | 8 | 53799 | 263 | 31643274 |
Haemophagocytic lymphohistiocytosis | 15.17 | 10.80 | 49 | 53758 | 11629 | 31631908 |
Pneumonia pneumococcal | 15.16 | 10.80 | 17 | 53790 | 1792 | 31641745 |
Sepsis | 15.16 | 10.80 | 351 | 53456 | 151578 | 31491959 |
Graft versus host disease in lung | 15.14 | 10.80 | 10 | 53797 | 511 | 31643026 |
Herpes zoster reactivation | 15.09 | 10.80 | 8 | 53799 | 271 | 31643266 |
Melaena | 15.06 | 10.80 | 20 | 53787 | 32634 | 31610903 |
Aeromonas infection | 14.98 | 10.80 | 8 | 53799 | 275 | 31643262 |
Cytomegalovirus infection | 14.93 | 10.80 | 82 | 53725 | 24625 | 31618912 |
Bronchial haemorrhage | 14.80 | 10.80 | 11 | 53796 | 680 | 31642857 |
Gastrointestinal haemorrhage | 14.76 | 10.80 | 81 | 53726 | 82468 | 31561069 |
Haematochezia | 14.70 | 10.80 | 29 | 53778 | 40435 | 31603102 |
Bacterial sepsis | 14.60 | 10.80 | 28 | 53779 | 4800 | 31638737 |
Myelodysplastic syndrome | 14.52 | 10.80 | 68 | 53739 | 19183 | 31624354 |
Haemolytic anaemia | 14.49 | 10.80 | 43 | 53764 | 9753 | 31633784 |
Pityriasis rubra pilaris | 14.36 | 10.80 | 6 | 53801 | 117 | 31643420 |
Dermatitis exfoliative | 14.22 | 10.80 | 33 | 53774 | 6459 | 31637078 |
Cerebellar syndrome | 14.17 | 10.80 | 18 | 53789 | 2163 | 31641374 |
Depressed level of consciousness | 14.13 | 10.80 | 113 | 53694 | 38488 | 31605049 |
Disorientation | 14.11 | 10.80 | 95 | 53712 | 30649 | 31612888 |
Contraindicated product administered | 14.10 | 10.80 | 8 | 53799 | 19764 | 31623773 |
Blood osmolarity abnormal | 14.07 | 10.80 | 3 | 53804 | 3 | 31643534 |
Herpes zoster oticus | 14.04 | 10.80 | 6 | 53801 | 124 | 31643413 |
Amyotrophy | 13.98 | 10.80 | 9 | 53798 | 440 | 31643097 |
Retinal detachment | 13.97 | 10.80 | 28 | 53779 | 4958 | 31638579 |
Dermatitis bullous | 13.96 | 10.80 | 32 | 53775 | 6213 | 31637324 |
Venous thrombosis | 13.93 | 10.80 | 22 | 53785 | 3233 | 31640304 |
Hemiparesis | 13.91 | 10.80 | 4 | 53803 | 14890 | 31628647 |
Enterococcal sepsis | 13.88 | 10.80 | 15 | 53792 | 1518 | 31642019 |
Loss of consciousness | 13.78 | 10.80 | 76 | 53731 | 77279 | 31566258 |
Donor leukocyte infusion | 13.78 | 10.80 | 4 | 53803 | 24 | 31643513 |
Wheezing | 13.76 | 10.80 | 25 | 53782 | 35961 | 31607576 |
Folliculitis | 13.72 | 10.80 | 25 | 53782 | 4123 | 31639414 |
Adverse drug reaction | 13.50 | 10.80 | 81 | 53726 | 25120 | 31618417 |
Abdominal pain | 13.41 | 10.80 | 171 | 53636 | 145781 | 31497756 |
Benign neoplasm of skin | 13.35 | 10.80 | 5 | 53802 | 72 | 31643465 |
Flushing | 13.34 | 10.80 | 19 | 53788 | 30109 | 31613428 |
Arthralgia | 13.33 | 10.80 | 179 | 53628 | 151245 | 31492292 |
Aphasia | 13.31 | 10.80 | 68 | 53739 | 19863 | 31623674 |
Myoclonus | 13.30 | 10.80 | 53 | 53754 | 13937 | 31629600 |
CSF volume increased | 13.25 | 10.80 | 4 | 53803 | 28 | 31643509 |
Cerebrovascular accident | 13.14 | 10.80 | 80 | 53727 | 79404 | 31564133 |
Chronic kidney disease | 13.13 | 10.80 | 28 | 53779 | 37947 | 31605590 |
Facial paralysis | 13.11 | 10.80 | 42 | 53765 | 9927 | 31633610 |
Bacteraemia | 13.09 | 10.80 | 62 | 53745 | 17572 | 31625965 |
Metabolic acidosis | 13.01 | 10.80 | 30 | 53777 | 39547 | 31603990 |
Pneumonia haemophilus | 12.99 | 10.80 | 8 | 53799 | 362 | 31643175 |
Lymphocytosis | 12.94 | 10.80 | 17 | 53790 | 2112 | 31641425 |
Macular fibrosis | 12.85 | 10.80 | 8 | 53799 | 369 | 31643168 |
Pneumocystis jirovecii pneumonia | 12.71 | 10.80 | 63 | 53744 | 18188 | 31625349 |
Injury | 12.65 | 10.80 | 9 | 53798 | 19700 | 31623837 |
Renal tubular disorder | 12.64 | 10.80 | 25 | 53782 | 4385 | 31639152 |
Blood glucose increased | 12.60 | 10.80 | 57 | 53750 | 61026 | 31582511 |
Oesophagitis | 12.59 | 10.80 | 48 | 53759 | 12368 | 31631169 |
Haematemesis | 12.57 | 10.80 | 15 | 53792 | 25638 | 31617899 |
Renal ischaemia | 12.46 | 10.80 | 9 | 53798 | 532 | 31643005 |
Lactic acidosis | 12.38 | 10.80 | 22 | 53785 | 31915 | 31611622 |
Mixed dementia | 12.37 | 10.80 | 7 | 53800 | 270 | 31643267 |
Sleep disorder | 12.29 | 10.80 | 16 | 53791 | 26332 | 31617205 |
Product quality issue | 12.25 | 10.80 | 6 | 53801 | 16105 | 31627432 |
Streptococcal bacteraemia | 12.19 | 10.80 | 15 | 53792 | 1745 | 31641792 |
Pulmonary sepsis | 12.13 | 10.80 | 16 | 53791 | 1996 | 31641541 |
Oral herpes | 12.05 | 10.80 | 26 | 53781 | 4847 | 31638690 |
Plasmacytoma | 12 | 10.80 | 21 | 53786 | 3356 | 31640181 |
Bladder cancer | 11.95 | 10.80 | 5 | 53802 | 14720 | 31628817 |
Psoriasis | 11.94 | 10.80 | 40 | 53767 | 46679 | 31596858 |
Oral mucosal erythema | 11.94 | 10.80 | 8 | 53799 | 419 | 31643118 |
Lymphocytic lymphoma | 11.91 | 10.80 | 4 | 53803 | 41 | 31643496 |
Wrong strength | 11.85 | 10.80 | 5 | 53802 | 100 | 31643437 |
Diabetic ketoacidosis | 11.83 | 10.80 | 7 | 53800 | 16898 | 31626639 |
Pulmonary hypertension | 11.78 | 10.80 | 10 | 53797 | 20031 | 31623506 |
Serum sickness | 11.78 | 10.80 | 15 | 53792 | 1807 | 31641730 |
Retinitis | 11.77 | 10.80 | 7 | 53800 | 297 | 31643240 |
Gastric varices | 11.77 | 10.80 | 8 | 53799 | 429 | 31643108 |
Pneumonia viral | 11.76 | 10.80 | 19 | 53788 | 2845 | 31640692 |
Fall | 11.74 | 10.80 | 234 | 53573 | 185855 | 31457682 |
Rash erythematous | 11.66 | 10.80 | 72 | 53735 | 22555 | 31620982 |
Cardiac failure congestive | 11.56 | 10.80 | 83 | 53724 | 79304 | 31564233 |
Medication error | 11.50 | 10.80 | 13 | 53794 | 22759 | 31620778 |
Serotonin syndrome | 11.49 | 10.80 | 9 | 53798 | 18764 | 31624773 |
Feeding disorder | 11.38 | 10.80 | 30 | 53777 | 6356 | 31637181 |
Peripheral T-cell lymphoma unspecified recurrent | 11.34 | 10.80 | 4 | 53803 | 48 | 31643489 |
Anti-cyclic citrullinated peptide antibody positive | 11.32 | 10.80 | 13 | 53794 | 1407 | 31642130 |
Blood creatinine increased | 11.22 | 10.80 | 213 | 53594 | 88865 | 31554672 |
Colitis | 11.22 | 10.80 | 97 | 53710 | 33790 | 31609747 |
Pulmonary congestion | 11.22 | 10.80 | 4 | 53803 | 12979 | 31630558 |
Hospitalisation | 11.18 | 10.80 | 45 | 53762 | 49762 | 31593775 |
Hypereosinophilic syndrome | 11.14 | 10.80 | 6 | 53801 | 210 | 31643327 |
Pseudomonal bacteraemia | 11.12 | 10.80 | 12 | 53795 | 1212 | 31642325 |
Haemorrhage | 11.12 | 10.80 | 42 | 53765 | 47292 | 31596245 |
T-cell prolymphocytic leukaemia | 11.05 | 10.80 | 4 | 53803 | 52 | 31643485 |
Sopor | 10.98 | 10.80 | 3 | 53804 | 11549 | 31631988 |
Axonal neuropathy | 10.97 | 10.80 | 11 | 53796 | 1020 | 31642517 |
Platelet disorder | 10.83 | 10.80 | 13 | 53794 | 1474 | 31642063 |
Renal failure | 10.81 | 10.80 | 280 | 53527 | 123050 | 31520487 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Febrile neutropenia | 585.69 | 9.89 | 1042 | 99348 | 203276 | 70624778 |
Neurotoxicity | 405.70 | 9.89 | 337 | 100053 | 29489 | 70798565 |
Cytokine release syndrome | 357.79 | 9.89 | 298 | 100092 | 26169 | 70801885 |
Acute kidney injury | 352.98 | 9.89 | 1466 | 98924 | 473158 | 70354896 |
Neutropenia | 283.85 | 9.89 | 904 | 99486 | 256252 | 70571802 |
Toxic encephalopathy | 280.44 | 9.89 | 178 | 100212 | 10228 | 70817826 |
Encephalopathy | 278.61 | 9.89 | 388 | 100002 | 61273 | 70766781 |
Plasma cell myeloma | 273.37 | 9.89 | 421 | 99969 | 72780 | 70755274 |
Drug reaction with eosinophilia and systemic symptoms | 266.53 | 9.89 | 368 | 100022 | 57645 | 70770409 |
Hepatocellular injury | 251.28 | 9.89 | 318 | 100072 | 45773 | 70782281 |
Toxic skin eruption | 243.86 | 9.89 | 213 | 100177 | 19949 | 70808105 |
Thrombocytopenia | 242.62 | 9.89 | 817 | 99573 | 238293 | 70589761 |
Pyrexia | 240.75 | 9.89 | 1574 | 98816 | 605378 | 70222676 |
Agranulocytosis | 240.53 | 9.89 | 291 | 100099 | 40007 | 70788047 |
Altered state of consciousness | 235.62 | 9.89 | 287 | 100103 | 39735 | 70788319 |
Herpes zoster | 235.10 | 9.89 | 428 | 99962 | 84807 | 70743247 |
Completed suicide | 202.74 | 9.89 | 38 | 100352 | 227097 | 70600957 |
Rash maculo-papular | 189.07 | 9.89 | 291 | 100099 | 50254 | 70777800 |
Pancytopenia | 179.22 | 9.89 | 545 | 99845 | 150562 | 70677492 |
Dyslalia | 176.71 | 9.89 | 63 | 100327 | 951 | 70827103 |
Drug ineffective | 175.07 | 9.89 | 712 | 99678 | 939040 | 69889014 |
Febrile bone marrow aplasia | 174.58 | 9.89 | 141 | 100249 | 11850 | 70816204 |
Drug abuse | 171.34 | 9.89 | 9 | 100381 | 147247 | 70680807 |
Acute generalised exanthematous pustulosis | 170.97 | 9.89 | 155 | 100235 | 15242 | 70812812 |
Rheumatoid arthritis | 170.25 | 9.89 | 101 | 100289 | 291704 | 70536350 |
Dysarthria | 168.12 | 9.89 | 310 | 100080 | 62003 | 70766051 |
Synovitis | 146.95 | 9.89 | 9 | 100381 | 129219 | 70698835 |
Contraindicated product administered | 135.04 | 9.89 | 16 | 100374 | 134596 | 70693458 |
Nervous system disorder | 127.47 | 9.89 | 164 | 100226 | 23982 | 70804072 |
Herpes simplex | 120.66 | 9.89 | 111 | 100279 | 11121 | 70816933 |
Toxicity to various agents | 119.05 | 9.89 | 225 | 100165 | 381947 | 70446107 |
Drug hypersensitivity | 117.33 | 9.89 | 119 | 100271 | 262340 | 70565714 |
Ophthalmic herpes simplex | 111.57 | 9.89 | 41 | 100349 | 678 | 70827376 |
Dermatitis exfoliative generalised | 109.78 | 9.89 | 83 | 100307 | 6331 | 70821723 |
Bronchopulmonary aspergillosis | 108.29 | 9.89 | 141 | 100249 | 20861 | 70807193 |
Oral herpes | 105.92 | 9.89 | 150 | 100240 | 24036 | 70804018 |
Pemphigus | 103.59 | 9.89 | 3 | 100387 | 83033 | 70745021 |
Cholestasis | 103.45 | 9.89 | 217 | 100173 | 47655 | 70780399 |
Intentional overdose | 100.48 | 9.89 | 11 | 100379 | 98424 | 70729630 |
Joint swelling | 99.90 | 9.89 | 127 | 100263 | 253084 | 70574970 |
Tumour lysis syndrome | 98.80 | 9.89 | 136 | 100254 | 21224 | 70806830 |
Drug intolerance | 97.84 | 9.89 | 105 | 100285 | 225582 | 70602472 |
Septic shock | 91.90 | 9.89 | 358 | 100032 | 111900 | 70716154 |
Hepatic cytolysis | 89.98 | 9.89 | 123 | 100267 | 19069 | 70808985 |
Pneumonia | 88.61 | 9.89 | 1257 | 99133 | 594975 | 70233079 |
Neuropathy peripheral | 86.85 | 9.89 | 383 | 100007 | 126513 | 70701541 |
Systemic lupus erythematosus | 84.79 | 9.89 | 20 | 100370 | 101882 | 70726172 |
Therapeutic product effect decreased | 84.03 | 9.89 | 49 | 100341 | 142969 | 70685085 |
Drug interaction | 81.77 | 9.89 | 272 | 100118 | 381169 | 70446885 |
Lymphopenia | 81.29 | 9.89 | 142 | 100248 | 27217 | 70800837 |
Arthropathy | 80.53 | 9.89 | 57 | 100333 | 150000 | 70678054 |
Platelet count decreased | 80.04 | 9.89 | 478 | 99912 | 177744 | 70650310 |
Squamous cell carcinoma of skin | 79.44 | 9.89 | 94 | 100296 | 12618 | 70815436 |
Pathogen resistance | 79.38 | 9.89 | 96 | 100294 | 13183 | 70814871 |
Eosinophilia | 79.36 | 9.89 | 176 | 100214 | 40143 | 70787911 |
Swelling | 77.03 | 9.89 | 92 | 100298 | 188447 | 70639607 |
Glossodynia | 75.98 | 9.89 | 15 | 100375 | 86472 | 70741582 |
Wound | 75.31 | 9.89 | 23 | 100367 | 98709 | 70729345 |
Aplasia | 74.68 | 9.89 | 70 | 100320 | 7181 | 70820873 |
White blood cell count decreased | 69.89 | 9.89 | 446 | 99944 | 169695 | 70658359 |
Acute myeloid leukaemia | 67.71 | 9.89 | 141 | 100249 | 30799 | 70797255 |
Herpes virus infection | 66.73 | 9.89 | 63 | 100327 | 6521 | 70821533 |
Cytopenia | 65.12 | 9.89 | 100 | 100290 | 17223 | 70810831 |
Microsporidia infection | 62.97 | 9.89 | 29 | 100361 | 869 | 70827185 |
Hallucination | 62.23 | 9.89 | 243 | 100147 | 76017 | 70752037 |
Anti-cyclic citrullinated peptide antibody positive | 62.01 | 9.89 | 12 | 100378 | 70173 | 70757881 |
Suicide attempt | 61.59 | 9.89 | 18 | 100372 | 79492 | 70748562 |
Alopecia | 61.58 | 9.89 | 117 | 100273 | 198373 | 70629681 |
Hallucination, visual | 61.08 | 9.89 | 131 | 100259 | 29206 | 70798848 |
Immune effector cell-associated neurotoxicity syndrome | 60.51 | 9.89 | 48 | 100342 | 3930 | 70824124 |
Blood urea increased | 60.47 | 9.89 | 172 | 100218 | 45737 | 70782317 |
Pain | 60.42 | 9.89 | 584 | 99806 | 628232 | 70199822 |
Laryngitis fungal | 58.88 | 9.89 | 17 | 100373 | 123 | 70827931 |
Human herpesvirus 6 encephalitis | 57.82 | 9.89 | 23 | 100367 | 476 | 70827578 |
Helicobacter infection | 57.35 | 9.89 | 6 | 100384 | 55650 | 70772404 |
Blood creatinine increased | 56.96 | 9.89 | 372 | 100018 | 142629 | 70685425 |
Genital herpes | 56.10 | 9.89 | 35 | 100355 | 1950 | 70826104 |
Treatment failure | 56.08 | 9.89 | 73 | 100317 | 144069 | 70683985 |
Arthralgia | 55.13 | 9.89 | 452 | 99938 | 502938 | 70325116 |
COVID-19 | 54.93 | 9.89 | 295 | 100095 | 105462 | 70722592 |
Chronic lymphocytic leukaemia | 54.08 | 9.89 | 53 | 100337 | 5745 | 70822309 |
Abdominal discomfort | 53.95 | 9.89 | 142 | 100248 | 214516 | 70613538 |
Depressed level of consciousness | 53.93 | 9.89 | 256 | 100134 | 87175 | 70740879 |
Confusional state | 52.77 | 9.89 | 625 | 99765 | 283773 | 70544281 |
Encephalitis cytomegalovirus | 52.64 | 9.89 | 27 | 100363 | 1029 | 70827025 |
Duodenal ulcer perforation | 51.43 | 9.89 | 6 | 100384 | 51106 | 70776948 |
Graft versus host disease in gastrointestinal tract | 51.14 | 9.89 | 52 | 100338 | 5892 | 70822162 |
Graft versus host disease | 49.96 | 9.89 | 82 | 100308 | 14941 | 70813113 |
Pseudomonas infection | 49.33 | 9.89 | 93 | 100297 | 18901 | 70809153 |
Demodicidosis | 48.69 | 9.89 | 15 | 100375 | 139 | 70827915 |
Rectal prolapse | 48.02 | 9.89 | 32 | 100358 | 1997 | 70826057 |
Face oedema | 47.20 | 9.89 | 109 | 100281 | 25530 | 70802524 |
Bacterial sepsis | 46.88 | 9.89 | 56 | 100334 | 7591 | 70820463 |
Musculoskeletal stiffness | 46.79 | 9.89 | 86 | 100304 | 147674 | 70680380 |
Myoclonus | 46.29 | 9.89 | 110 | 100280 | 26245 | 70801809 |
Renal disorder | 45.83 | 9.89 | 138 | 100252 | 37871 | 70790183 |
Bradycardia | 44.59 | 9.89 | 67 | 100323 | 124548 | 70703506 |
Sepsis | 44.28 | 9.89 | 535 | 99855 | 244010 | 70584044 |
Delirium | 44.23 | 9.89 | 216 | 100174 | 74398 | 70753656 |
Discomfort | 43.52 | 9.89 | 51 | 100339 | 105385 | 70722669 |
Rheumatoid factor positive | 43.34 | 9.89 | 8 | 100382 | 48392 | 70779662 |
Neutrophil count decreased | 43.33 | 9.89 | 233 | 100157 | 83323 | 70744731 |
Renal tubular disorder | 41.22 | 9.89 | 47 | 100343 | 6063 | 70821991 |
Cytomegalovirus infection | 40.32 | 9.89 | 136 | 100254 | 39622 | 70788432 |
Drug resistance | 39.94 | 9.89 | 132 | 100258 | 38058 | 70789996 |
Thrombotic microangiopathy | 39.83 | 9.89 | 82 | 100308 | 17766 | 70810288 |
Hypoglycaemia | 39.64 | 9.89 | 45 | 100345 | 94319 | 70733735 |
Maternal exposure during pregnancy | 39.37 | 9.89 | 64 | 100326 | 115281 | 70712773 |
Mobility decreased | 39.20 | 9.89 | 53 | 100337 | 102946 | 70725108 |
International normalised ratio increased | 39.08 | 9.89 | 34 | 100356 | 80692 | 70747362 |
Dyspnoea | 38.99 | 9.89 | 813 | 99577 | 769247 | 70058807 |
Hypersensitivity | 38.87 | 9.89 | 180 | 100210 | 229632 | 70598422 |
Mixed liver injury | 38.70 | 9.89 | 46 | 100344 | 6203 | 70821851 |
Escherichia bacteraemia | 37.67 | 9.89 | 44 | 100346 | 5825 | 70822229 |
Bladder prolapse | 37.48 | 9.89 | 23 | 100367 | 1244 | 70826810 |
Plasma cell myeloma recurrent | 37.35 | 9.89 | 38 | 100352 | 4308 | 70823746 |
Ophthalmic herpes zoster | 37.02 | 9.89 | 29 | 100361 | 2331 | 70825723 |
Pneumocystis jirovecii pneumonia | 37.01 | 9.89 | 110 | 100280 | 29972 | 70798082 |
Injection site inflammation | 36.97 | 9.89 | 34 | 100356 | 3404 | 70824650 |
Therapeutic product effect incomplete | 36.87 | 9.89 | 71 | 100319 | 119811 | 70708243 |
Hepatitis cholestatic | 36.72 | 9.89 | 65 | 100325 | 12585 | 70815469 |
Vocal cord dysfunction | 35.81 | 9.89 | 16 | 100374 | 446 | 70827608 |
Hyperuricaemia | 33.99 | 9.89 | 58 | 100332 | 10908 | 70817146 |
Pain in extremity | 33.87 | 9.89 | 299 | 100091 | 327783 | 70500271 |
Cerebral toxoplasmosis | 33.58 | 9.89 | 26 | 100364 | 2054 | 70826000 |
Nephritis allergic | 33.43 | 9.89 | 17 | 100373 | 636 | 70827418 |
Psychiatric symptom | 33.31 | 9.89 | 44 | 100346 | 6600 | 70821454 |
Impaired healing | 32.87 | 9.89 | 34 | 100356 | 74340 | 70753714 |
Disorientation | 32.42 | 9.89 | 165 | 100225 | 57758 | 70770296 |
Tumour flare | 32.10 | 9.89 | 19 | 100371 | 962 | 70827092 |
Wrong technique in product usage process | 31.98 | 9.89 | 30 | 100360 | 68668 | 70759386 |
Drug dependence | 31.69 | 9.89 | 7 | 100383 | 37314 | 70790740 |
Deep vein thrombosis | 31.19 | 9.89 | 266 | 100124 | 110776 | 70717278 |
Intentional self-injury | 31.14 | 9.89 | 4 | 100386 | 31646 | 70796408 |
Aspergillus infection | 30.75 | 9.89 | 74 | 100316 | 17794 | 70810260 |
Mucosal inflammation | 30.43 | 9.89 | 182 | 100208 | 67668 | 70760386 |
Cardiac arrest | 30.20 | 9.89 | 120 | 100270 | 159714 | 70668340 |
Rhabdomyolysis | 30.07 | 9.89 | 56 | 100334 | 95704 | 70732350 |
Varicella zoster virus infection | 30.03 | 9.89 | 33 | 100357 | 4087 | 70823967 |
Rhinovirus infection | 29.83 | 9.89 | 42 | 100348 | 6691 | 70821363 |
Hyperthermia | 29.73 | 9.89 | 70 | 100320 | 16601 | 70811453 |
Renal failure | 29.70 | 9.89 | 403 | 99987 | 188667 | 70639387 |
Red blood cell sedimentation rate increased | 29.46 | 9.89 | 9 | 100381 | 38633 | 70789421 |
Death | 29.26 | 9.89 | 527 | 99863 | 509534 | 70318520 |
Dermatitis exfoliative | 29.08 | 9.89 | 53 | 100337 | 10498 | 70817556 |
Squamous cell carcinoma | 29.01 | 9.89 | 64 | 100326 | 14540 | 70813514 |
Escherichia sepsis | 28.99 | 9.89 | 44 | 100346 | 7499 | 70820555 |
Encephalitis | 28.66 | 9.89 | 61 | 100329 | 13524 | 70814530 |
COVID-19 pneumonia | 28.62 | 9.89 | 82 | 100308 | 21887 | 70806167 |
Serotonin syndrome | 28.38 | 9.89 | 12 | 100378 | 42102 | 70785952 |
Haemophagocytic lymphohistiocytosis | 28.32 | 9.89 | 76 | 100314 | 19536 | 70808518 |
Lung disorder | 27.79 | 9.89 | 181 | 100209 | 69303 | 70758751 |
Irritable bowel syndrome | 27.68 | 9.89 | 19 | 100371 | 50831 | 70777223 |
C-reactive protein abnormal | 27.64 | 9.89 | 10 | 100380 | 38569 | 70789485 |
Eosinophilic colitis | 27.38 | 9.89 | 13 | 100377 | 418 | 70827636 |
Hypogammaglobulinaemia | 26.92 | 9.89 | 54 | 100336 | 11484 | 70816570 |
Speech disorder | 26.87 | 9.89 | 142 | 100248 | 50438 | 70777616 |
Genital herpes simplex | 26.84 | 9.89 | 12 | 100378 | 335 | 70827719 |
CSF cell count increased | 26.76 | 9.89 | 9 | 100381 | 113 | 70827941 |
Lymphocyte count decreased | 26.48 | 9.89 | 127 | 100263 | 43412 | 70784642 |
Sopor | 26.27 | 9.89 | 6 | 100384 | 31261 | 70796793 |
Conjunctival irritation | 25.80 | 9.89 | 9 | 100381 | 127 | 70827927 |
Restlessness | 25.71 | 9.89 | 123 | 100267 | 42005 | 70786049 |
Differentiation syndrome | 25.69 | 9.89 | 23 | 100367 | 2224 | 70825830 |
Osteoarthritis | 25.43 | 9.89 | 41 | 100349 | 74106 | 70753948 |
Purpura | 25.29 | 9.89 | 69 | 100321 | 17906 | 70810148 |
Psoriatic arthropathy | 24.98 | 9.89 | 33 | 100357 | 64738 | 70763316 |
Genital erythema | 24.20 | 9.89 | 10 | 100380 | 229 | 70827825 |
Musculoskeletal pain | 24.03 | 9.89 | 58 | 100332 | 90269 | 70737785 |
Peripheral swelling | 23.78 | 9.89 | 217 | 100173 | 236346 | 70591708 |
Intentional product misuse | 23.73 | 9.89 | 48 | 100342 | 79547 | 70748507 |
Toxic erythema of chemotherapy | 23.69 | 9.89 | 10 | 100380 | 242 | 70827812 |
Hyperbilirubinaemia | 23.59 | 9.89 | 78 | 100312 | 22490 | 70805564 |
Pulmonary sarcoidosis | 23.52 | 9.89 | 17 | 100373 | 1210 | 70826844 |
Blood glucose increased | 23.01 | 9.89 | 72 | 100318 | 102910 | 70725144 |
Viral mutation identified | 22.99 | 9.89 | 27 | 100363 | 3595 | 70824459 |
Laryngeal stenosis | 22.90 | 9.89 | 15 | 100375 | 909 | 70827145 |
Bacteraemia | 22.77 | 9.89 | 92 | 100298 | 29217 | 70798837 |
Cerebellar stroke | 22.54 | 9.89 | 12 | 100378 | 494 | 70827560 |
Fall | 22.35 | 9.89 | 469 | 99921 | 443627 | 70384427 |
Respiratory arrest | 22.35 | 9.89 | 26 | 100364 | 53907 | 70774147 |
Product use issue | 22.26 | 9.89 | 156 | 100234 | 179781 | 70648273 |
Mucosal excoriation | 22.25 | 9.89 | 4 | 100386 | 0 | 70828054 |
Sedation | 22.23 | 9.89 | 20 | 100370 | 46711 | 70781343 |
Hyperleukocytosis | 22.19 | 9.89 | 21 | 100369 | 2180 | 70825874 |
Herpes ophthalmic | 21.99 | 9.89 | 17 | 100373 | 1340 | 70826714 |
Eye infection toxoplasmal | 21.81 | 9.89 | 12 | 100378 | 528 | 70827526 |
Metastases to liver | 21.68 | 9.89 | 5 | 100385 | 25873 | 70802181 |
Infective exacerbation of chronic obstructive airways disease | 21.66 | 9.89 | 22 | 100368 | 2489 | 70825565 |
Atrial fibrillation | 21.64 | 9.89 | 374 | 100016 | 183974 | 70644080 |
Ichthyosis | 21.62 | 9.89 | 8 | 100382 | 135 | 70827919 |
Terminal ileitis | 21.61 | 9.89 | 13 | 100377 | 678 | 70827376 |
Acute pulmonary oedema | 21.44 | 9.89 | 54 | 100336 | 13358 | 70814696 |
Aplastic anaemia | 21.40 | 9.89 | 62 | 100328 | 16654 | 70811400 |
Serum sickness | 21.36 | 9.89 | 25 | 100365 | 3316 | 70824738 |
Diarrhoea | 21.36 | 9.89 | 1332 | 99058 | 782009 | 70046045 |
Cell death | 21.34 | 9.89 | 28 | 100362 | 4172 | 70823882 |
Nocardiosis | 21.26 | 9.89 | 31 | 100359 | 5098 | 70822956 |
Fibromyalgia | 21.02 | 9.89 | 22 | 100368 | 47852 | 70780202 |
Malignant neoplasm of unknown primary site | 21.02 | 9.89 | 13 | 100377 | 713 | 70827341 |
Haemorrhoids thrombosed | 21.02 | 9.89 | 9 | 100381 | 226 | 70827828 |
Anaphylactic reaction | 20.86 | 9.89 | 47 | 100343 | 74927 | 70753127 |
Streptococcal bacteraemia | 20.84 | 9.89 | 24 | 100366 | 3129 | 70824925 |
Obesity | 20.84 | 9.89 | 6 | 100384 | 26765 | 70801289 |
Contusion | 20.63 | 9.89 | 102 | 100288 | 127934 | 70700120 |
Hepatic enzyme increased | 20.47 | 9.89 | 134 | 100256 | 156856 | 70671198 |
Venoocclusive liver disease | 20.32 | 9.89 | 46 | 100344 | 10632 | 70817422 |
Blood lactate dehydrogenase increased | 20.32 | 9.89 | 101 | 100289 | 35026 | 70793028 |
Respiratory tract infection bacterial | 20.29 | 9.89 | 18 | 100372 | 1719 | 70826335 |
Eye infection bacterial | 20.11 | 9.89 | 9 | 100381 | 252 | 70827802 |
Parainfluenzae virus infection | 20.05 | 9.89 | 30 | 100360 | 5050 | 70823004 |
Dermatitis bullous | 20.02 | 9.89 | 51 | 100339 | 12706 | 70815348 |
Injection site pain | 19.94 | 9.89 | 92 | 100298 | 117527 | 70710527 |
Epstein-Barr virus infection | 19.92 | 9.89 | 52 | 100338 | 13146 | 70814908 |
Renal impairment | 19.88 | 9.89 | 300 | 100090 | 143637 | 70684417 |
Drug withdrawal syndrome | 19.50 | 9.89 | 11 | 100379 | 32704 | 70795350 |
Vaccination failure | 19.47 | 9.89 | 16 | 100374 | 1377 | 70826677 |
Pancreatitis acute | 19.44 | 9.89 | 120 | 100270 | 45104 | 70782950 |
Coronary artery disease | 19.42 | 9.89 | 37 | 100353 | 62699 | 70765355 |
Cerebellar syndrome | 19.38 | 9.89 | 30 | 100360 | 5201 | 70822853 |
Bronchopneumopathy | 19.18 | 9.89 | 12 | 100378 | 672 | 70827382 |
Fungal endocarditis | 19.10 | 9.89 | 11 | 100379 | 529 | 70827525 |
Pneumonia fungal | 19.08 | 9.89 | 43 | 100347 | 9910 | 70818144 |
Asthma | 19.02 | 9.89 | 97 | 100293 | 120696 | 70707358 |
Acute HIV infection | 18.98 | 9.89 | 6 | 100384 | 61 | 70827993 |
Hip arthroplasty | 18.88 | 9.89 | 8 | 100382 | 28032 | 70800022 |
Myocardial infarction | 18.78 | 9.89 | 154 | 100236 | 171491 | 70656563 |
Acute febrile neutrophilic dermatosis | 18.72 | 9.89 | 24 | 100366 | 3495 | 70824559 |
Axonal neuropathy | 18.56 | 9.89 | 18 | 100372 | 1926 | 70826128 |
Colitis | 18.51 | 9.89 | 154 | 100236 | 63660 | 70764394 |
SARS-CoV-2 sepsis | 18.50 | 9.89 | 7 | 100383 | 126 | 70827928 |
Skin lesion | 18.43 | 9.89 | 105 | 100285 | 38355 | 70789699 |
Post herpetic neuralgia | 18.29 | 9.89 | 20 | 100370 | 2464 | 70825590 |
Foreign body in reproductive tract | 17.75 | 9.89 | 10 | 100380 | 461 | 70827593 |
Full blood count decreased | 17.73 | 9.89 | 74 | 100316 | 23844 | 70804210 |
Campylobacter colitis | 17.59 | 9.89 | 5 | 100385 | 34 | 70828020 |
Product tampering | 17.58 | 9.89 | 8 | 100382 | 233 | 70827821 |
Lower respiratory tract infection | 17.54 | 9.89 | 90 | 100300 | 111823 | 70716231 |
Glomerulosclerosis | 17.51 | 9.89 | 13 | 100377 | 964 | 70827090 |
Myelodysplastic syndrome | 17.48 | 9.89 | 86 | 100304 | 29699 | 70798355 |
Metastases to bone | 17.44 | 9.89 | 5 | 100385 | 22371 | 70805683 |
Graft versus host disease in lung | 17.19 | 9.89 | 12 | 100378 | 808 | 70827246 |
Urine output decreased | 17.16 | 9.89 | 58 | 100332 | 16912 | 70811142 |
Knee arthroplasty | 17.15 | 9.89 | 14 | 100376 | 34287 | 70793767 |
Neutropenic colitis | 17.12 | 9.89 | 28 | 100362 | 5086 | 70822968 |
Mucormycosis | 16.92 | 9.89 | 36 | 100354 | 7978 | 70820076 |
Muscle rigidity | 16.88 | 9.89 | 3 | 100387 | 18647 | 70809407 |
Enteritis | 16.82 | 9.89 | 48 | 100342 | 12783 | 70815271 |
Acute lymphocytic leukaemia | 16.75 | 9.89 | 29 | 100361 | 5516 | 70822538 |
Haemolytic anaemia | 16.63 | 9.89 | 57 | 100333 | 16737 | 70811317 |
Gastrointestinal disorder | 16.40 | 9.89 | 85 | 100305 | 105342 | 70722712 |
Arthritis | 16.39 | 9.89 | 77 | 100313 | 97903 | 70730151 |
Angina pectoris | 16.36 | 9.89 | 27 | 100363 | 48356 | 70779698 |
Lactic acidosis | 16.32 | 9.89 | 43 | 100347 | 64981 | 70763073 |
Brief psychotic disorder with marked stressors | 16.22 | 9.89 | 8 | 100382 | 280 | 70827774 |
Bicytopenia | 16.20 | 9.89 | 24 | 100366 | 4004 | 70824050 |
Posterior reversible encephalopathy syndrome | 16.18 | 9.89 | 73 | 100317 | 24329 | 70803725 |
Morganella infection | 16.13 | 9.89 | 13 | 100377 | 1089 | 70826965 |
Gastrointestinal haemorrhage | 16.09 | 9.89 | 121 | 100269 | 137287 | 70690767 |
Peripheral T-cell lymphoma unspecified recurrent | 16.07 | 9.89 | 5 | 100385 | 48 | 70828006 |
Labelled drug-drug interaction medication error | 16.06 | 9.89 | 7 | 100383 | 24120 | 70803934 |
Disseminated cryptococcosis | 16.05 | 9.89 | 16 | 100374 | 1771 | 70826283 |
Pseudomonal bacteraemia | 16.04 | 9.89 | 19 | 100371 | 2553 | 70825501 |
Cardiac failure congestive | 15.99 | 9.89 | 119 | 100271 | 135338 | 70692716 |
Biopsy skin abnormal | 15.98 | 9.89 | 7 | 100383 | 186 | 70827868 |
Laryngeal cancer metastatic | 15.89 | 9.89 | 5 | 100385 | 50 | 70828004 |
Loss of personal independence in daily activities | 15.87 | 9.89 | 64 | 100326 | 84846 | 70743208 |
Logorrhoea | 15.82 | 9.89 | 24 | 100366 | 4090 | 70823964 |
Pneumonia influenzal | 15.81 | 9.89 | 19 | 100371 | 2591 | 70825463 |
Rash morbilliform | 15.80 | 9.89 | 28 | 100362 | 5427 | 70822627 |
Diffuse large B-cell lymphoma | 15.75 | 9.89 | 48 | 100342 | 13254 | 70814800 |
Aphasia | 15.70 | 9.89 | 110 | 100280 | 43139 | 70784915 |
Blister | 15.67 | 9.89 | 81 | 100309 | 100445 | 70727609 |
Meningoencephalitis herpetic | 15.66 | 9.89 | 16 | 100374 | 1823 | 70826231 |
Rash erythematous | 15.64 | 9.89 | 126 | 100264 | 51592 | 70776462 |
Weight increased | 15.61 | 9.89 | 245 | 100145 | 242086 | 70585968 |
Extrapyramidal disorder | 15.52 | 9.89 | 5 | 100385 | 20745 | 70807309 |
Amyotrophy | 15.51 | 9.89 | 10 | 100380 | 590 | 70827464 |
Bacterial vaginosis | 15.50 | 9.89 | 12 | 100378 | 948 | 70827106 |
Venoocclusive disease | 15.44 | 9.89 | 24 | 100366 | 4176 | 70823878 |
Device malfunction | 15.37 | 9.89 | 4 | 100386 | 19080 | 70808974 |
Neuropsychiatric syndrome | 15.37 | 9.89 | 6 | 100384 | 118 | 70827936 |
Depression | 15.36 | 9.89 | 194 | 100196 | 198780 | 70629274 |
Erythema multiforme | 15.35 | 9.89 | 55 | 100335 | 16509 | 70811545 |
Complications of transplanted heart | 15.33 | 9.89 | 8 | 100382 | 316 | 70827738 |
Limbic encephalitis | 15.32 | 9.89 | 11 | 100379 | 775 | 70827279 |
Rash vesicular | 15.31 | 9.89 | 27 | 100363 | 5213 | 70822841 |
Actinic keratosis | 15.30 | 9.89 | 28 | 100362 | 5562 | 70822492 |
Blood cholesterol increased | 15.27 | 9.89 | 44 | 100346 | 64560 | 70763494 |
Pityriasis rubra pilaris | 15.23 | 9.89 | 6 | 100384 | 121 | 70827933 |
Wheezing | 15.18 | 9.89 | 75 | 100315 | 94095 | 70733959 |
Joint range of motion decreased | 15.16 | 9.89 | 9 | 100381 | 26017 | 70802037 |
Bone marrow failure | 15.15 | 9.89 | 120 | 100270 | 48890 | 70779164 |
Botryomycosis | 15.15 | 9.89 | 5 | 100385 | 59 | 70827995 |
Neurological symptom | 15.13 | 9.89 | 33 | 100357 | 7440 | 70820614 |
Portal vein cavernous transformation | 15.09 | 9.89 | 6 | 100384 | 124 | 70827930 |
Cytomegalovirus chorioretinitis | 15.09 | 9.89 | 27 | 100363 | 5271 | 70822783 |
Bacillus bacteraemia | 15.05 | 9.89 | 6 | 100384 | 125 | 70827929 |
Blood creatine phosphokinase increased | 15.01 | 9.89 | 41 | 100349 | 61222 | 70766832 |
Neuralgia | 14.98 | 9.89 | 80 | 100310 | 28523 | 70799531 |
Decreased appetite | 14.82 | 9.89 | 549 | 99841 | 304231 | 70523823 |
Imperception | 14.61 | 9.89 | 3 | 100387 | 3 | 70828051 |
Klebsiella sepsis | 14.58 | 9.89 | 19 | 100371 | 2812 | 70825242 |
Pseudomyopia | 14.57 | 9.89 | 5 | 100385 | 67 | 70827987 |
Enterococcal sepsis | 14.50 | 9.89 | 18 | 100372 | 2539 | 70825515 |
Hypertension | 14.47 | 9.89 | 314 | 100076 | 295719 | 70532335 |
Facial paralysis | 14.46 | 9.89 | 61 | 100329 | 19747 | 70808307 |
Acute respiratory distress syndrome | 14.43 | 9.89 | 104 | 100286 | 41150 | 70786904 |
Aeromonas infection | 14.33 | 9.89 | 8 | 100382 | 362 | 70827692 |
Dyscalculia | 14.30 | 9.89 | 5 | 100385 | 71 | 70827983 |
Nephropathy toxic | 14.29 | 9.89 | 58 | 100332 | 18456 | 70809598 |
Crystalluria | 14.26 | 9.89 | 11 | 100379 | 864 | 70827190 |
Cerebrovascular accident | 14.23 | 9.89 | 132 | 100258 | 143338 | 70684716 |
Toxic neuropathy | 14.23 | 9.89 | 11 | 100379 | 867 | 70827187 |
Acute myocardial infarction | 14.22 | 9.89 | 54 | 100336 | 72833 | 70755221 |
Folliculitis | 14.17 | 9.89 | 24 | 100366 | 42546 | 70785508 |
Escherichia infection | 14.10 | 9.89 | 53 | 100337 | 16278 | 70811776 |
Flushing | 14.09 | 9.89 | 64 | 100326 | 82108 | 70745946 |
Lymphocytosis | 13.98 | 9.89 | 22 | 100368 | 3868 | 70824186 |
Body temperature decreased | 13.97 | 9.89 | 12 | 100378 | 28660 | 70799394 |
Infective aneurysm | 13.84 | 9.89 | 11 | 100379 | 903 | 70827151 |
Neurosis | 13.72 | 9.89 | 8 | 100382 | 394 | 70827660 |
Incorrect disposal of product | 13.70 | 9.89 | 11 | 100379 | 916 | 70827138 |
Herpes zoster oticus | 13.64 | 9.89 | 8 | 100382 | 398 | 70827656 |
Hepatic cirrhosis | 13.63 | 9.89 | 14 | 100376 | 30717 | 70797337 |
Infective chondritis | 13.62 | 9.89 | 4 | 100386 | 31 | 70828023 |
Product administration error | 13.61 | 9.89 | 13 | 100377 | 29510 | 70798544 |
Cyanosis | 13.55 | 9.89 | 8 | 100382 | 23198 | 70804856 |
Vitiligo | 13.50 | 9.89 | 15 | 100375 | 1880 | 70826174 |
Rhegmatogenous retinal detachment | 13.44 | 9.89 | 6 | 100384 | 167 | 70827887 |
Tractional retinal detachment | 13.42 | 9.89 | 5 | 100385 | 86 | 70827968 |
Plasmacytoma | 13.31 | 9.89 | 22 | 100368 | 4032 | 70824022 |
Mixed dementia | 13.27 | 9.89 | 7 | 100383 | 283 | 70827771 |
Haematemesis | 13.24 | 9.89 | 31 | 100359 | 48766 | 70779288 |
Wrong strength | 13.15 | 9.89 | 6 | 100384 | 176 | 70827878 |
Cytomegalovirus test positive | 13.12 | 9.89 | 26 | 100364 | 5482 | 70822572 |
Soliloquy | 13.11 | 9.89 | 9 | 100381 | 590 | 70827464 |
Campylobacter gastroenteritis | 13.10 | 9.89 | 12 | 100378 | 1195 | 70826859 |
CSF volume increased | 13.09 | 9.89 | 4 | 100386 | 36 | 70828018 |
Necrotising retinitis | 13.07 | 9.89 | 12 | 100378 | 1199 | 70826855 |
Lymphocytic infiltration | 13.04 | 9.89 | 13 | 100377 | 1439 | 70826615 |
Rash pustular | 12.97 | 9.89 | 38 | 100352 | 10270 | 70817784 |
Varicella virus test positive | 12.90 | 9.89 | 6 | 100384 | 184 | 70827870 |
Melaena | 12.87 | 9.89 | 39 | 100351 | 56316 | 70771738 |
Persecutory delusion | 12.84 | 9.89 | 23 | 100367 | 4494 | 70823560 |
Mycobacterial peritonitis | 12.77 | 9.89 | 5 | 100385 | 99 | 70827955 |
Embedded device | 12.77 | 9.89 | 18 | 100372 | 2871 | 70825183 |
Pneumocystis jirovecii infection | 12.73 | 9.89 | 17 | 100373 | 2577 | 70825477 |
Acute lymphocytic leukaemia recurrent | 12.72 | 9.89 | 24 | 100366 | 4880 | 70823174 |
Glossoptosis | 12.69 | 9.89 | 6 | 100384 | 191 | 70827863 |
Condition aggravated | 12.68 | 9.89 | 486 | 99904 | 427149 | 70400905 |
Blood pressure increased | 12.68 | 9.89 | 189 | 100201 | 188328 | 70639726 |
Lymphocytic lymphoma | 12.64 | 9.89 | 5 | 100385 | 102 | 70827952 |
Cytomegalovirus colitis | 12.64 | 9.89 | 22 | 100368 | 4204 | 70823850 |
Laryngeal inflammation | 12.64 | 9.89 | 6 | 100384 | 193 | 70827861 |
Gastrooesophageal reflux disease | 12.63 | 9.89 | 76 | 100314 | 90763 | 70737291 |
Schizophrenia | 12.61 | 9.89 | 4 | 100386 | 16764 | 70811290 |
Periorbital cellulitis | 12.60 | 9.89 | 10 | 100380 | 819 | 70827235 |
Depressed mood | 12.57 | 9.89 | 27 | 100363 | 43793 | 70784261 |
Cryopyrin associated periodic syndrome | 12.55 | 9.89 | 6 | 100384 | 196 | 70827858 |
Peripheral T-cell lymphoma unspecified | 12.55 | 9.89 | 10 | 100380 | 824 | 70827230 |
Benign neoplasm of skin | 12.55 | 9.89 | 5 | 100385 | 104 | 70827950 |
Generalised tonic-clonic seizure | 12.52 | 9.89 | 25 | 100365 | 41636 | 70786418 |
Malignant neoplasm progression | 12.51 | 9.89 | 111 | 100279 | 121628 | 70706426 |
Hypercholesterolaemia | 12.47 | 9.89 | 5 | 100385 | 18112 | 70809942 |
Pseudolymphoma | 12.44 | 9.89 | 11 | 100379 | 1046 | 70827008 |
Klebsiella bacteraemia | 12.42 | 9.89 | 17 | 100373 | 2637 | 70825417 |
Progressive multifocal leukoencephalopathy | 12.38 | 9.89 | 57 | 100333 | 19157 | 70808897 |
Poriomania | 12.33 | 9.89 | 6 | 100384 | 204 | 70827850 |
Accidental exposure to product | 12.19 | 9.89 | 13 | 100377 | 28038 | 70800016 |
Thrombotic thrombocytopenic purpura | 12.19 | 9.89 | 27 | 100363 | 6150 | 70821904 |
Citrobacter infection | 12.16 | 9.89 | 10 | 100380 | 862 | 70827192 |
Respiratory tract infection | 12.13 | 9.89 | 102 | 100288 | 42296 | 70785758 |
Injection site swelling | 12.05 | 9.89 | 27 | 100363 | 43130 | 70784924 |
Pulmonary embolism | 11.95 | 9.89 | 297 | 100093 | 155570 | 70672484 |
Venous thrombosis | 11.94 | 9.89 | 28 | 100362 | 6621 | 70821433 |
Blood creatinine abnormal | 11.93 | 9.89 | 22 | 100368 | 4397 | 70823657 |
Drug monitoring procedure not performed | 11.92 | 9.89 | 10 | 100380 | 886 | 70827168 |
Peripheral nerve palsy | 11.91 | 9.89 | 4 | 100386 | 50 | 70828004 |
Haematochezia | 11.89 | 9.89 | 58 | 100332 | 73023 | 70755031 |
Medication error | 11.87 | 9.89 | 41 | 100349 | 56871 | 70771183 |
Cryptosporidiosis infection | 11.84 | 9.89 | 9 | 100381 | 692 | 70827362 |
Leukaemia recurrent | 11.84 | 9.89 | 17 | 100373 | 2758 | 70825296 |
Platelet count increased | 11.82 | 9.89 | 7 | 100383 | 20266 | 70807788 |
Gingival erosion | 11.77 | 9.89 | 5 | 100385 | 123 | 70827931 |
Metabolic encephalopathy | 11.66 | 9.89 | 32 | 100358 | 8331 | 70819723 |
Sleep disorder | 11.64 | 9.89 | 55 | 100335 | 69817 | 70758237 |
Lichenification | 11.62 | 9.89 | 9 | 100381 | 711 | 70827343 |
Poisoning | 11.60 | 9.89 | 9 | 100381 | 22613 | 70805441 |
Exostosis | 11.57 | 9.89 | 3 | 100387 | 14342 | 70813712 |
Fracture | 11.47 | 9.89 | 7 | 100383 | 19937 | 70808117 |
Hypotension | 11.46 | 9.89 | 462 | 99928 | 403919 | 70424135 |
Bone marrow necrosis | 11.41 | 9.89 | 6 | 100384 | 241 | 70827813 |
Respiratory depression | 11.37 | 9.89 | 11 | 100379 | 24820 | 70803234 |
Respiratory tract infection viral | 11.33 | 9.89 | 19 | 100371 | 3522 | 70824532 |
Thermal burn | 11.31 | 9.89 | 27 | 100363 | 6459 | 70821595 |
Cerebral thrombosis | 11.30 | 9.89 | 15 | 100375 | 2261 | 70825793 |
Right ventricular failure | 11.25 | 9.89 | 9 | 100381 | 22265 | 70805789 |
Blood pressure systolic abnormal | 11.23 | 9.89 | 42 | 100348 | 12867 | 70815187 |
Rash | 11.20 | 9.89 | 853 | 99537 | 509709 | 70318345 |
Hyperphosphataemia | 11.18 | 9.89 | 21 | 100369 | 4255 | 70823799 |
Tri-iodothyronine free increased | 11.05 | 9.89 | 6 | 100384 | 257 | 70827797 |
Ectropion | 11.01 | 9.89 | 7 | 100383 | 403 | 70827651 |
Hypoglycaemic seizure | 10.97 | 9.89 | 9 | 100381 | 773 | 70827281 |
Melanaemia | 10.95 | 9.89 | 4 | 100386 | 65 | 70827989 |
Parkinsonism | 10.93 | 9.89 | 4 | 100386 | 15321 | 70812733 |
Hypercapnic coma | 10.92 | 9.89 | 7 | 100383 | 409 | 70827645 |
Erythema annulare | 10.85 | 9.89 | 5 | 100385 | 150 | 70827904 |
Polymyositis | 10.83 | 9.89 | 17 | 100373 | 2984 | 70825070 |
Arteriosclerosis | 10.80 | 9.89 | 5 | 100385 | 16633 | 70811421 |
Pulmonary hypertension | 10.77 | 9.89 | 32 | 100358 | 46504 | 70781550 |
Superinfection bacterial | 10.77 | 9.89 | 11 | 100379 | 1253 | 70826801 |
Cardiomyopathy acute | 10.76 | 9.89 | 6 | 100384 | 271 | 70827783 |
Gastric varices | 10.76 | 9.89 | 8 | 100382 | 595 | 70827459 |
Haemorrhagic occlusive retinal vasculitis | 10.74 | 9.89 | 3 | 100387 | 19 | 70828035 |
Meningitis enteroviral | 10.73 | 9.89 | 4 | 100386 | 69 | 70827985 |
Herpes simplex meningoencephalitis | 10.73 | 9.89 | 4 | 100386 | 69 | 70827985 |
Incorrect route of product administration | 10.73 | 9.89 | 13 | 100377 | 26479 | 70801575 |
Pseudomonal sepsis | 10.70 | 9.89 | 24 | 100366 | 5513 | 70822541 |
Central nervous system necrosis | 10.62 | 9.89 | 6 | 100384 | 278 | 70827776 |
Fluid imbalance | 10.60 | 9.89 | 7 | 100383 | 430 | 70827624 |
Pulmonary congestion | 10.56 | 9.89 | 12 | 100378 | 25142 | 70802912 |
Dermo-hypodermitis | 10.55 | 9.89 | 8 | 100382 | 613 | 70827441 |
Vitamin D decreased | 10.54 | 9.89 | 31 | 100359 | 8396 | 70819658 |
Disability | 10.54 | 9.89 | 4 | 100386 | 14979 | 70813075 |
Pyelitis | 10.45 | 9.89 | 6 | 100384 | 287 | 70827767 |
Type 2 diabetes mellitus | 10.43 | 9.89 | 30 | 100360 | 44050 | 70784004 |
Pneumonia klebsiella | 10.41 | 9.89 | 21 | 100369 | 4483 | 70823571 |
Tuberculosis | 10.38 | 9.89 | 4 | 100386 | 14844 | 70813210 |
Neurocryptococcosis | 10.36 | 9.89 | 3 | 100387 | 22 | 70828032 |
Cholecystitis chronic | 10.33 | 9.89 | 33 | 100357 | 9343 | 70818711 |
Anuria | 10.31 | 9.89 | 55 | 100335 | 19598 | 70808456 |
Dry mouth | 10.30 | 9.89 | 58 | 100332 | 70399 | 70757655 |
Gingival ulceration | 10.24 | 9.89 | 9 | 100381 | 849 | 70827205 |
Incoherent | 10.23 | 9.89 | 28 | 100362 | 7278 | 70820776 |
Tongue disorder | 10.23 | 9.89 | 3 | 100387 | 13224 | 70814830 |
Disseminated varicella zoster virus infection | 10.21 | 9.89 | 7 | 100383 | 458 | 70827596 |
Peripheral sensory neuropathy | 10.21 | 9.89 | 39 | 100351 | 12071 | 70815983 |
Pericarditis | 10.19 | 9.89 | 74 | 100316 | 84631 | 70743423 |
Autoimmune haemolytic anaemia | 10.17 | 9.89 | 29 | 100361 | 7717 | 70820337 |
Injection site erythema | 10.14 | 9.89 | 61 | 100329 | 72863 | 70755191 |
T-cell prolymphocytic leukaemia | 10.14 | 9.89 | 4 | 100386 | 81 | 70827973 |
Adverse event | 10.07 | 9.89 | 36 | 100354 | 49425 | 70778629 |
Photosensitivity reaction | 10.07 | 9.89 | 54 | 100336 | 19286 | 70808768 |
Drug level increased | 10.04 | 9.89 | 87 | 100303 | 36382 | 70791672 |
Electrocardiogram QT prolonged | 10.03 | 9.89 | 73 | 100317 | 83444 | 70744610 |
Adenocarcinoma of colon | 10.01 | 9.89 | 23 | 100367 | 5369 | 70822685 |
Bladder cancer | 9.99 | 9.89 | 6 | 100384 | 17236 | 70810818 |
Pulmonary fibrosis | 9.96 | 9.89 | 21 | 100369 | 34289 | 70793765 |
None
Source | Code | Description |
---|---|---|
ATC | J05AB11 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleosides and nucleotides excl. reverse transcriptase inhibitors |
FDA MoA | N0000020060 | DNA Polymerase Inhibitors |
FDA EXT | N0000175459 | Nucleoside Analog |
FDA EPC | N0000175468 | Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000998 | Antiviral Agents |
FDA EPC | N0000180187 | Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor |
FDA EPC | N0000180188 | Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Herpes labialis | indication | 1475003 | |
Herpes zoster | indication | 4740000 | DOID:8536 |
Genital herpes simplex | indication | 33839006 | DOID:8704 |
Varicella | indication | 38907003 | DOID:8659 |
Recurrent genital herpes simplex | indication | 402894005 | |
Suppression of Recurrent Herpes Simplex Infection in HIV | indication | ||
Suppression of Recurrent Herpes Simplex Infection | indication | ||
Prevention of Cytomegalovirus Disease | off-label use | ||
Prevention of Herpes Zoster in Immunocompromised Patient | off-label use | ||
Dehydration | contraindication | 34095006 | |
Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
Hemolytic uremic syndrome | contraindication | 111407006 | DOID:12554 |
Impaired renal function disorder | contraindication | 197663003 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.97 | acidic |
pKa2 | 7.83 | Basic |
pKa3 | 3.83 | Basic |
pKa4 | 2.12 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
DNA polymerase catalytic subunit | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL |
ID | Source |
---|---|
4024006 | VUID |
N0000022011 | NUI |
D08664 | KEGG_DRUG |
124832-26-4 | SECONDARY_CAS_RN |
4020944 | VANDF |
4024006 | VANDF |
C0249458 | UMLSCUI |
CHEBI:9919 | CHEBI |
TXC | PDB_CHEM_ID |
CHEMBL1349 | ChEMBL_ID |
CHEMBL1201110 | ChEMBL_ID |
DB00577 | DRUGBANK_ID |
4824 | IUPHAR_LIGAND_ID |
MZ1IW7Q79D | UNII |
135398742 | PUBCHEM_CID |
236081 | RXNORM |
169290 | MMSL |
5660 | MMSL |
d03838 | MMSL |
005049 | NDDF |
005050 | NDDF |
324820003 | SNOMEDCT_US |
412325002 | SNOMEDCT_US |
96098007 | SNOMEDCT_US |
D000077483 | MESH_DESCRIPTOR_UI |
7106 | INN_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
VALTREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0565 | TABLET, FILM COATED | 1 g | ORAL | NDA | 25 sections |
VALTREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0565 | TABLET, FILM COATED | 1 g | ORAL | NDA | 25 sections |
VALTREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0565 | TABLET, FILM COATED | 1 g | ORAL | NDA | 25 sections |
VALTREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0933 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 25 sections |
VALTREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0933 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 25 sections |
VALTREX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0933 | TABLET, FILM COATED | 500 mg | ORAL | NDA | 25 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4275 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 27 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-4276 | TABLET, FILM COATED | 1 g | ORAL | ANDA | 27 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5208 | TABLET | 500 mg | ORAL | ANDA | 25 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5209 | TABLET | 1 g | ORAL | ANDA | 25 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6565 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 25 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6565 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 25 sections |
valacyclovir hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-937 | TABLET, FILM COATED | 1 g | ORAL | ANDA | 23 sections |
Valacyclovir Hydrochloride | Human Prescription Drug Label | 1 | 16714-697 | TABLET, FILM COATED | 1 g | ORAL | ANDA | 25 sections |
Valacyclovir Hydrochloride | Human Prescription Drug Label | 1 | 16714-697 | TABLET, FILM COATED | 1 g | ORAL | ANDA | 25 sections |
Valacyclovir Hydrochloride | Human Prescription Drug Label | 1 | 16714-698 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 25 sections |
Valacyclovir Hydrochloride | Human Prescription Drug Label | 1 | 16714-698 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 25 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-832 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 27 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-965 | TABLET, FILM COATED | 1 g | ORAL | ANDA | 27 sections |
Valacyclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-704 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 24 sections |
Valacyclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 31722-705 | TABLET, FILM COATED | 1 g | ORAL | ANDA | 24 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-730 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 25 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-730 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 25 sections |
Valacyclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-771 | TABLET, FILM COATED | 1 g | ORAL | ANDA | 24 sections |
Valacyclovir | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-771 | TABLET, FILM COATED | 1 g | ORAL | ANDA | 24 sections |
Valacyclovir hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-778 | TABLET | 500 mg | ORAL | ANDA | 27 sections |
Valacyclovir hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-778 | TABLET | 500 mg | ORAL | ANDA | 27 sections |
Valacyclovir | Human Prescription Drug Label | 1 | 43353-883 | TABLET, FILM COATED | 500 mg | ORAL | ANDA | 26 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49483-690 | TABLET | 500 mg | ORAL | ANDA | 26 sections |
Valacyclovir Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49483-691 | TABLET | 1 g | ORAL | ANDA | 26 sections |