valaciclovir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals bicyclic heterocycle compounds 2798 124832-27-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • valacyclovir
  • valaciclovir
  • valcivir
  • valacyclovir hydrochloride
  • valacyclovir HCl
A prodrug of acyclovir that is used in the treatment of HERPES ZOSTER and HERPES SIMPLEX VIRUS INFECTION of the skin and mucous membranes, including GENITAL HERPES.
  • Molecular weight: 324.34
  • Formula: C13H20N6O4
  • CLOGP: -1.22
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 3
  • TPSA: 146.85
  • ALOGS: -1.97
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 174 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 154.16 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
June 23, 1995 FDA GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Altered state of consciousness 318.81 9.91 251 71057 22770 56197989
Acute kidney injury 305.88 9.91 828 70480 239935 55980824
Febrile neutropenia 246.57 9.91 463 70845 105082 56115677
Rheumatoid arthritis 239.22 9.91 93 71215 382511 55838248
Plasma cell myeloma 227.63 9.91 288 71020 46358 56174401
Neurotoxicity 216.05 9.91 171 71137 15624 56205135
Encephalopathy 204.76 9.91 238 71070 35087 56185672
Contraindicated product administered 201.27 9.91 8 71300 186278 56034481
Toxic encephalopathy 198.07 9.91 112 71196 5826 56214933
Herpes zoster 187.31 9.91 341 70967 75548 56145211
Pemphigus 183.83 9.91 3 71305 157209 56063550
Drug ineffective 183.17 9.91 579 70729 918410 55302349
Cytokine release syndrome 173.43 9.91 129 71179 10746 56210013
Synovitis 170.68 9.91 8 71300 161297 56059462
Hepatocellular injury 164.40 9.91 185 71123 26329 56194430
Hand deformity 155.45 9.91 3 71305 134489 56086270
Toxic skin eruption 149.72 9.91 122 71186 11617 56209142
Drug reaction with eosinophilia and systemic symptoms 149.22 9.91 188 71120 30116 56190643
Glossodynia 148.02 9.91 12 71296 152446 56068313
Neutropenia 147.36 9.91 488 70820 157679 56063080
Dysarthria 147.01 9.91 214 71094 39336 56181423
Dyslalia 146.39 9.91 44 71264 421 56220338
Systemic lupus erythematosus 135.52 9.91 31 71277 180047 56040712
Oral herpes 127.27 9.91 151 71157 22739 56198020
Herpes simplex 126.23 9.91 92 71216 7426 56213333
Treatment failure 124.93 9.91 31 71277 170361 56050398
Blood urea increased 123.96 9.91 154 71154 24319 56196440
Agranulocytosis 115.43 9.91 143 71165 22516 56198243
Wound 114.73 9.91 19 71289 138785 56081974
Drug intolerance 110.04 9.91 104 71204 264714 55956045
Joint swelling 110.03 9.91 123 71185 289677 55931082
Arthropathy 106.02 9.91 61 71247 200214 56020545
Pancytopenia 96.57 9.91 289 71019 88426 56132333
Drug hypersensitivity 95.76 9.91 125 71183 275080 55945679
Herpes virus infection 95.37 9.91 67 71241 5103 56215656
Therapeutic product effect decreased 94.95 9.91 48 71260 169404 56051355
Swelling 90.72 9.91 102 71206 239669 55981090
Thrombocytopenia 87.36 9.91 373 70935 135851 56084908
Rash maculo-papular 87.15 9.91 142 71166 28765 56191994
Alopecia 85.95 9.91 150 71158 293308 55927451
White blood cell count decreased 82.35 9.91 347 70961 125643 56095116
Neuropathy peripheral 82.31 9.91 302 71006 102591 56118168
Completed suicide 81.04 9.91 34 71274 133799 56086960
Abdominal discomfort 80.95 9.91 142 71166 277132 55943627
Blood creatinine increased 79.61 9.91 253 71055 79938 56140821
Helicobacter infection 76.29 9.91 4 71304 73264 56147495
Pyrexia 75.85 9.91 837 70471 417936 55802823
Febrile bone marrow aplasia 74.88 9.91 64 71244 6508 56214251
Nervous system disorder 74.11 9.91 99 71209 16790 56203969
Pericarditis 70.36 9.91 25 71283 108898 56111861
Intentional overdose 70.05 9.91 4 71304 68113 56152646
Maternal exposure during pregnancy 64.96 9.91 87 71221 189466 56031293
Discomfort 64.50 9.91 51 71257 141710 56079049
Laryngitis fungal 64.47 9.91 18 71290 129 56220630
Platelet count decreased 63.38 9.91 285 71023 106098 56114661
Rheumatoid factor positive 60.39 9.91 8 71300 69052 56151707
Acute generalised exanthematous pustulosis 59.69 9.91 68 71240 9801 56210958
Drug abuse 58.72 9.91 8 71300 67602 56153157
Diarrhoea 58.44 9.91 1133 70175 637374 55583385
Rectal prolapse 56.24 9.91 33 71275 1841 56218918
Muscle injury 54.24 9.91 3 71305 52497 56168262
Depressed level of consciousness 54.14 9.91 176 71132 56257 56164502
Injection site inflammation 53.29 9.91 40 71268 3376 56217383
Tumour lysis syndrome 52.05 9.91 57 71251 7866 56212893
Dermatitis exfoliative generalised 51.04 9.91 39 71269 3381 56217378
Pain 50.70 9.91 567 70741 662617 55558142
Product use issue 49.22 9.91 101 71207 185940 56034819
Genital herpes 49.09 9.91 29 71279 1638 56219121
Diffuse large B-cell lymphoma refractory 47.90 9.91 25 71283 1107 56219652
Hallucination, visual 47.56 9.91 82 71226 17386 56203373
Encephalitis cytomegalovirus 47.43 9.91 20 71288 542 56220217
Lymphopenia 47.33 9.91 80 71228 16694 56204065
Renal disorder 46.99 9.91 111 71197 29494 56191265
Septic shock 45.66 9.91 175 71133 60660 56160099
Aplasia 43.67 9.91 38 71270 3958 56216801
Vocal cord dysfunction 43.23 9.91 17 71291 383 56220376
Arthralgia 43.14 9.91 417 70891 501252 55719507
Hepatic enzyme increased 42.87 9.91 96 71212 171288 56049471
Musculoskeletal stiffness 42.71 9.91 83 71225 155924 56064835
Impaired healing 41.07 9.91 30 71278 86811 56133948
Mobility decreased 40.90 9.91 39 71269 98952 56121807
Ophthalmic herpes simplex 40.90 9.91 17 71291 444 56220315
Cholestasis 40.66 9.91 99 71209 26814 56193945
Cytomegalovirus infection 40.51 9.91 81 71227 19215 56201544
Folliculitis 40.26 9.91 10 71298 54969 56165790
Immune effector cell-associated neurotoxicity syndrome 39.73 9.91 25 71283 1583 56219176
Eosinophilia 39.45 9.91 82 71226 19995 56200764
Hypersensitivity 38.70 9.91 180 71128 256228 55964531
Bronchopulmonary aspergillosis 38.66 9.91 50 71258 8214 56212545
Human herpesvirus 6 encephalitis 38.58 9.91 13 71295 185 56220574
Acute myeloid leukaemia 37.76 9.91 73 71235 16899 56203860
Lower respiratory tract infection 36.03 9.91 56 71252 114738 56106021
Therapeutic product effect incomplete 35.96 9.91 49 71259 105982 56114777
Delirium 34.99 9.91 126 71182 42391 56178368
Toxicity to various agents 34.27 9.91 157 71151 224407 55996352
Post herpetic neuralgia 34.25 9.91 25 71283 2022 56218737
Graft versus host disease 33.26 9.91 42 71266 6739 56214020
Bladder prolapse 33.03 9.91 24 71284 1927 56218832
Suicide attempt 32.94 9.91 16 71292 57820 56162939
Full blood count decreased 32.24 9.91 83 71225 23266 56197493
Myoclonus 32.13 9.91 64 71244 15139 56205620
Renal impairment 31.92 9.91 193 71115 80520 56140239
Genital herpes simplex 31.84 9.91 12 71296 240 56220519
Plasma cell myeloma recurrent 31.57 9.91 27 71281 2747 56218012
Toxic erythema of chemotherapy 30.29 9.91 10 71298 133 56220626
Infusion related reaction 30.16 9.91 149 71159 208782 56011977
Urine output decreased 29.88 9.91 51 71257 10726 56210033
Renal tubular disorder 29.77 9.91 25 71283 2481 56218278
Fungal endocarditis 29.14 9.91 11 71297 221 56220538
Irritable bowel syndrome 28.24 9.91 27 71281 68431 56152328
Bacterial sepsis 28.22 9.91 29 71279 3720 56217039
Ophthalmic herpes zoster 28.18 9.91 21 71287 1753 56219006
Cerebellar stroke 28.05 9.91 11 71297 246 56220513
Laboratory test abnormal 27.36 9.91 81 71227 24614 56196145
Blood uric acid increased 26.97 9.91 30 71278 4212 56216547
Hepatic cytolysis 26.86 9.91 49 71259 10857 56209902
Cytopenia 26.83 9.91 46 71262 9709 56211050
Neutrophil count decreased 26.37 9.91 129 71179 49693 56171066
Sepsis 26.34 9.91 282 71026 139558 56081201
Deep vein thrombosis 26.08 9.91 177 71131 76800 56143959
Drug interaction 25.66 9.91 158 71150 209597 56011162
Restlessness 25.56 9.91 83 71225 26503 56194256
Psychiatric symptom 25.35 9.91 31 71277 4813 56215946
Psoriatic arthropathy 25.29 9.91 34 71274 73974 56146785
Lymphocyte count decreased 24.88 9.91 85 71223 27854 56192905
Disorientation 24.79 9.91 102 71206 36511 56184248
Laryngeal stenosis 24.60 9.91 15 71293 898 56219861
Cytomegalovirus chorioretinitis 24.55 9.91 19 71289 1679 56219080
C-reactive protein abnormal 24.54 9.91 8 71300 36801 56183958
COVID-19 23.90 9.91 170 71138 74888 56145871
Pneumonia 23.68 9.91 679 70629 406419 55814340
Posterior reversible encephalopathy syndrome 23.35 9.91 58 71250 15902 56204857
Serotonin syndrome 23.32 9.91 3 71305 26487 56194272
Infective aneurysm 23.23 9.91 11 71297 394 56220365
Pathogen resistance 23.06 9.91 33 71275 5967 56214792
Hip arthroplasty 23.06 9.91 10 71298 38613 56182146
Hallucination 23.03 9.91 123 71185 49026 56171733
Escherichia bacteraemia 22.92 9.91 25 71283 3435 56217324
COVID-19 pneumonia 22.58 9.91 46 71262 11056 56209703
Loss of personal independence in daily activities 22.51 9.91 43 71265 81326 56139433
Eye infection bacterial 22.38 9.91 8 71300 137 56220622
Decreased appetite 22.32 9.91 396 70912 218835 56001924
Plasmacytoma 22.14 9.91 21 71287 2445 56218314
Product tampering 22.09 9.91 9 71299 223 56220536
Skin lesion 21.98 9.91 82 71226 28053 56192706
Mixed liver injury 21.89 9.91 26 71282 3918 56216841
Mucormycosis 21.87 9.91 22 71286 2752 56218007
Neuropsychiatric syndrome 21.87 9.91 6 71302 40 56220719
Intentional self-injury 21.60 9.91 3 71305 24989 56195770
Terminal ileitis 21.38 9.91 12 71296 615 56220144
Vitamin D decreased 21.35 9.91 40 71268 9043 56211716
Biopsy skin abnormal 21.28 9.91 7 71301 92 56220667
Squamous cell carcinoma of skin 21.19 9.91 30 71278 5372 56215387
Spina bifida 21.07 9.91 13 71295 795 56219964
Cerebral ventricle dilatation 20.99 9.91 14 71294 979 56219780
Bicytopenia 20.76 9.91 19 71289 2114 56218645
Congenital herpes simplex infection 20.46 9.91 4 71304 3 56220756
Metabolic encephalopathy 20.23 9.91 29 71279 5251 56215508
Knee arthroplasty 20.01 9.91 16 71292 44243 56176516
Mucosal excoriation 19.92 9.91 4 71304 4 56220755
Pneumocystis jirovecii pneumonia 19.83 9.91 54 71254 15647 56205112
Meningoencephalitis herpetic 19.65 9.91 14 71294 1090 56219669
Red blood cell sedimentation rate increased 19.57 9.91 11 71297 36612 56184147
Bacterial vaginosis 19.34 9.91 14 71294 1118 56219641
Cryptosporidiosis infection 19.23 9.91 9 71299 314 56220445
Liver injury 19.08 9.91 15 71293 41833 56178926
Bone marrow necrosis 18.81 9.91 6 71302 71 56220688
Dyspnoea 18.51 9.91 591 70717 591986 55628773
Campylobacter colitis 18.40 9.91 5 71303 32 56220727
Bradycardia 18.38 9.91 36 71272 67468 56153291
Speech disorder 18.37 9.91 95 71213 37398 56183361
Anaphylactic reaction 18.30 9.91 29 71279 58966 56161793
Gastrointestinal disorder 18.26 9.91 77 71231 112625 56108134
Foreign body in reproductive tract 18.19 9.91 10 71298 492 56220267
Vitiligo 18.16 9.91 14 71294 1230 56219529
Ectropion 18.08 9.91 7 71301 151 56220608
Epstein-Barr virus associated lymphoma 17.95 9.91 10 71298 505 56220254
Dermo-hypodermitis 17.88 9.91 8 71300 251 56220508
Sedation 17.87 9.91 11 71297 34843 56185916
Cell death 17.57 9.91 18 71290 2301 56218458
Neurological symptom 17.55 9.91 26 71282 4850 56215909
Drug monitoring procedure not performed 17.47 9.91 10 71298 532 56220227
International normalised ratio increased 17.44 9.91 18 71290 44023 56176736
Acute pulmonary oedema 17.29 9.91 33 71275 7564 56213195
Congenital pyelocaliectasis 17.02 9.91 3 71305 0 56220759
Sopor 16.97 9.91 3 71305 20919 56199840
Soliloquy 16.73 9.91 7 71301 186 56220573
Mycetoma mycotic 16.69 9.91 4 71304 14 56220745
Pseudolymphoma 16.65 9.91 10 71298 582 56220177
Tractional retinal detachment 16.62 9.91 5 71303 48 56220711
Herpes ophthalmic 16.54 9.91 13 71295 1175 56219584
Asthma 16.50 9.91 80 71228 112690 56108069
Hyperthermia 16.47 9.91 34 71274 8251 56212508
Infective chondritis 16.27 9.91 4 71304 16 56220743
Hepatitis acute 16.26 9.91 34 71274 8323 56212436
Confusional state 16.15 9.91 361 70947 207794 56012965
Portal vein cavernous transformation 16.01 9.91 6 71302 118 56220641
Pseudomyopia 16.01 9.91 5 71303 55 56220704
Hypoglycaemic seizure 15.99 9.91 9 71299 464 56220295
Cholecystitis chronic 15.96 9.91 37 71271 9711 56211048
Chronic papillomatous dermatitis 15.93 9.91 5 71303 56 56220703
Metastases to liver 15.66 9.91 4 71304 21582 56199177
Chronic lymphocytic leukaemia 15.44 9.91 19 71289 2969 56217790
Laryngeal inflammation 15.43 9.91 6 71302 131 56220628
Central nervous system necrosis 15.35 9.91 6 71302 133 56220626
Accidental exposure to product 15.33 9.91 6 71302 24641 56196118
Epstein-Barr virus infection 15.27 9.91 31 71277 7432 56213327
Aspergillus infection 15.27 9.91 31 71277 7434 56213325
Thermal burn 15.26 9.91 26 71282 5459 56215300
Hepatitis E 15.12 9.91 13 71295 1332 56219427
Neurosis 14.99 9.91 7 71301 243 56220516
Imperception 14.94 9.91 3 71305 3 56220756
Citrobacter sepsis 14.94 9.91 3 71305 3 56220756
Nausea 14.82 9.91 1141 70167 763037 55457722
Blood pressure systolic abnormal 14.80 9.91 36 71272 9741 56211018
Renal failure 14.79 9.91 209 71099 110291 56110468
Rhabdomyolysis 14.59 9.91 18 71290 40640 56180119
Limbic encephalitis 14.55 9.91 7 71301 260 56220499
Feeling abnormal 14.55 9.91 244 71064 133358 56087401
Cryopyrin associated periodic syndrome 14.49 9.91 6 71302 155 56220604
Constipation 14.36 9.91 346 70962 201597 56019162
Venoocclusive disease 14.36 9.91 15 71293 1962 56218797
Hepatitis 14.16 9.91 85 71223 35356 56185403
Gamma-glutamyltransferase increased 14.12 9.91 77 71231 30928 56189831
Human ehrlichiosis 14.11 9.91 6 71302 166 56220593
Eye infection toxoplasmal 14.07 9.91 7 71301 280 56220479
Lichenification 14.06 9.91 8 71300 421 56220338
CSF cell count increased 14.05 9.91 4 71304 31 56220728
Pain in extremity 14.02 9.91 279 71029 297152 55923607
Peripheral swelling 14.02 9.91 211 71097 234515 55986244
Mycobacterial peritonitis 13.86 9.91 5 71303 88 56220671
Blister 13.84 9.91 81 71227 108806 56111953
Embedded device 13.83 9.91 18 71290 2975 56217784
Antiviral drug level above therapeutic 13.73 9.91 3 71305 6 56220753
Meningocele 13.73 9.91 3 71305 6 56220753
Pyelitis 13.69 9.91 6 71302 179 56220580
Disseminated varicella zoster virus infection 13.66 9.91 6 71302 180 56220579
Type 2 diabetes mellitus 13.64 9.91 24 71284 46838 56173921
Cardiac failure congestive 13.55 9.91 61 71247 87659 56133100
Hepatitis cholestatic 13.55 9.91 27 71281 6387 56214372
Pharyngeal inflammation 13.54 9.91 9 71299 626 56220133
Seasonal allergy 13.48 9.91 50 71258 17058 56203701
Bone marrow failure 13.39 9.91 71 71237 28215 56192544
Dermatitis exfoliative 13.29 9.91 24 71284 5275 56215484
Inappropriate antidiuretic hormone secretion 13.27 9.91 43 71265 13713 56207046
Leukaemia recurrent 13.26 9.91 12 71296 1316 56219443
Vision blurred 13.24 9.91 162 71146 82781 56137978
Psychiatric decompensation 13.18 9.91 12 71296 1326 56219433
Neuralgia 13.00 9.91 62 71246 23633 56197126
Rhegmatogenous retinal detachment 13.00 9.91 5 71303 106 56220653
Coronary artery disease 12.87 9.91 12 71296 30784 56189975
Rash pustular 12.84 9.91 27 71281 6636 56214123
Musculoskeletal pain 12.80 9.91 56 71252 81096 56139663
Cardiac arrest 12.76 9.91 61 71247 86253 56134506
Blood lactate dehydrogenase increased 12.76 9.91 56 71252 20619 56200140
Pulmonary arterial hypertension 12.73 9.91 9 71299 26494 56194265
Autoimmune nephritis 12.68 9.91 7 71301 347 56220412
Graft versus host disease in gastrointestinal tract 12.54 9.91 17 71291 2922 56217837
Tri-iodothyronine free increased 12.54 9.91 6 71302 220 56220539
Condition aggravated 12.48 9.91 337 70971 344561 55876198
Subacute combined cord degeneration 12.44 9.91 6 71302 224 56220535
Cardiomyopathy acute 12.37 9.91 6 71302 227 56220532
Kussmaul respiration 12.34 9.91 6 71302 228 56220531
Osteoarthritis 12.31 9.91 56 71252 80240 56140519
Aminoaciduria 12.23 9.91 5 71303 125 56220634
Thrombosis 12.20 9.91 122 71186 59305 56161454
Contusion 12.18 9.91 104 71204 128326 56092433
Fibromyalgia 12.12 9.91 37 71271 59566 56161193
Blood cholesterol increased 12.12 9.91 49 71259 72530 56148229
Progressive multifocal leukoencephalopathy 12.00 9.91 38 71270 11975 56208784
Acute febrile neutrophilic dermatosis 11.99 9.91 16 71292 2709 56218050
Streptococcal bacteraemia 11.97 9.91 12 71296 1495 56219264
Hepatic cirrhosis 11.93 9.91 6 71302 21257 56199502
Tandem gait test abnormal 11.83 9.91 3 71305 14 56220745
Acute respiratory distress syndrome 11.76 9.91 57 71251 21869 56198890
Angina bullosa haemorrhagica 11.74 9.91 5 71303 139 56220620
Rash vesicular 11.74 9.91 19 71289 3826 56216933
Escherichia pyelonephritis 11.73 9.91 7 71301 403 56220356
Metastases to bone 11.73 9.91 5 71303 19503 56201256
Nystagmus 11.69 9.91 24 71284 5801 56214958
Oliguria 11.65 9.91 30 71278 8410 56212349
Dizziness 11.60 9.91 585 70723 375555 55845204
Incoherent 11.57 9.91 20 71288 4249 56216510
Anal infection 11.56 9.91 4 71304 62 56220697
Death 11.48 9.91 337 70971 341089 55879670
Tumour flare 11.45 9.91 6 71302 268 56220491
Lymphocyte morphology abnormal 11.43 9.91 7 71301 422 56220337
Cerebral thrombosis 11.43 9.91 12 71296 1578 56219181
Hypouricaemia 11.41 9.91 5 71303 149 56220610
Hemianopia homonymous 11.41 9.91 8 71300 607 56220152
Hypophagia 11.38 9.91 69 71239 28807 56191952
Unevaluable event 11.33 9.91 101 71207 47586 56173173
Therapeutic response decreased 11.27 9.91 32 71276 52726 56168033
Pneumocystis jirovecii infection 11.24 9.91 11 71297 1331 56219428
Visual acuity reduced 11.20 9.91 54 71254 20672 56200087
Haemophagocytic lymphohistiocytosis 11.18 9.91 32 71276 9540 56211219
Cholestatic liver injury 11.13 9.91 14 71294 2238 56218521
Varicella zoster virus infection 11.11 9.91 15 71293 2569 56218190
Scab 11.09 9.91 26 71282 6872 56213887
Monocyte percentage increased 11.08 9.91 10 71298 1093 56219666
Haemorrhagic occlusive retinal vasculitis 11.07 9.91 3 71305 19 56220740
Emotional distress 11.02 9.91 70 71238 29693 56191066
Adulterated product 10.95 9.91 4 71304 73 56220686
Coordination abnormal 10.89 9.91 38 71270 12583 56208176
Thrombotic thrombocytopenic purpura 10.85 9.91 18 71290 3699 56217060
Nephritis 10.85 9.91 14 71294 2295 56218464
Limb injury 10.61 9.91 56 71252 22214 56198545
Macrocytosis 10.58 9.91 14 71294 2352 56218407
Pancreatitis acute 10.52 9.91 61 71247 25063 56195696
Gastrointestinal haemorrhage 10.47 9.91 55 71253 75896 56144863
Joint range of motion decreased 10.46 9.91 10 71298 25355 56195404
Asterixis 10.35 9.91 10 71298 1191 56219568
Somatic symptom disorder 10.31 9.91 13 71295 2082 56218677
Chills 10.30 9.91 185 71123 102419 56118340
Acute myopia 10.30 9.91 4 71304 87 56220672
Hyperuricaemia 10.30 9.91 21 71287 5052 56215707
Cytomegalovirus colitis 10.28 9.91 13 71295 2089 56218670
Product substitution issue 10.14 9.91 41 71267 14558 56206201
Tympanic membrane perforation 10.13 9.91 12 71296 1803 56218956
Disseminated cytomegaloviral infection 10.10 9.91 5 71303 198 56220561
Cytomegalovirus test positive 10.07 9.91 15 71293 2811 56217948
Chronic obstructive pulmonary disease 10.07 9.91 38 71270 57377 56163382
Erythema annulare 10.02 9.91 4 71304 94 56220665

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 345.45 10.80 686 53121 121163 31522374
Cytokine release syndrome 218.01 10.80 199 53608 16443 31627094
Neutropenia 178.04 10.80 583 53224 139781 31503756
Neurotoxicity 176.32 10.80 175 53632 16051 31627486
Plasma cell myeloma 167.91 10.80 325 53482 56206 31587331
Pyrexia 159.75 10.80 969 52838 302871 31340666
Thrombocytopenia 150.68 10.80 558 53249 142189 31501348
Encephalopathy 146.85 10.80 225 53582 32249 31611288
Acute generalised exanthematous pustulosis 138.09 10.80 100 53707 5940 31637597
Herpes zoster 134.00 10.80 214 53593 31779 31611758
Completed suicide 130.03 10.80 6 53801 91508 31552029
Febrile bone marrow aplasia 125.20 10.80 105 53702 7741 31635796
Drug reaction with eosinophilia and systemic symptoms 124.63 10.80 200 53607 29818 31613719
Drug abuse 120.75 10.80 7 53800 87751 31555786
Agranulocytosis 120.59 10.80 164 53643 21083 31622454
Toxic encephalopathy 110.19 10.80 80 53727 4770 31638767
Hepatocellular injury 105.55 10.80 155 53652 21389 31622148
Acute kidney injury 102.86 10.80 818 52989 278896 31364641
Toxicity to various agents 101.74 10.80 95 53712 181392 31462145
Rash maculo-papular 99.51 10.80 166 53641 25553 31617984
Pancytopenia 97.61 10.80 348 53459 86968 31556569
Toxic skin eruption 92.90 10.80 100 53707 10080 31633457
Neuropathy peripheral 88.41 10.80 306 53501 75343 31568194
Dyslalia 87.09 10.80 33 53774 492 31643045
Altered state of consciousness 82.94 10.80 137 53670 20914 31622623
Dysarthria 78.34 10.80 170 53637 31847 31611690
Nervous system disorder 77.72 10.80 104 53703 13159 31630378
Ophthalmic herpes simplex 76.18 10.80 26 53781 281 31643256
Dermatitis exfoliative generalised 75.49 10.80 54 53753 3145 31640392
Pneumonia 75.29 10.80 884 52923 334428 31309109
Drug ineffective 72.54 10.80 386 53421 395187 31248350
Bronchopulmonary aspergillosis 71.01 10.80 101 53706 13533 31630004
Microsporidia infection 67.69 10.80 29 53778 603 31642934
White blood cell count decreased 67.05 10.80 310 53497 87088 31556449
Squamous cell carcinoma of skin 63.04 10.80 82 53725 10092 31633445
Drug interaction 62.62 10.80 166 53641 208377 31435160
Cholestasis 60.03 10.80 132 53675 24943 31618594
Cytopenia 57.98 10.80 82 53725 10928 31632609
Tumour lysis syndrome 57.76 10.80 98 53709 15287 31628250
Cerebral toxoplasmosis 57.66 10.80 35 53772 1542 31641995
Hepatic cytolysis 57.58 10.80 81 53726 10742 31632795
Demodicidosis 47.42 10.80 15 53792 125 31643412
Pathogen resistance 46.11 10.80 65 53742 8636 31634901
Face oedema 45.78 10.80 72 53735 10544 31632993
Intentional overdose 44.91 10.80 8 53799 41381 31602156
COVID-19 43.90 10.80 197 53610 54624 31588913
Chronic lymphocytic leukaemia 43.39 10.80 47 53760 4769 31638768
Platelet count decreased 43.14 10.80 328 53479 110107 31533430
Suicide attempt 43.13 10.80 6 53801 37242 31606295
Hypoglycaemia 40.27 10.80 18 53789 50928 31592609
Genital herpes 40.23 10.80 20 53787 591 31642946
Acute myeloid leukaemia 38.84 10.80 93 53714 18579 31624958
Dyspnoea 38.22 10.80 386 53421 343093 31300444
Pseudomonas infection 38.09 10.80 69 53738 11332 31632205
Nephritis allergic 37.95 10.80 17 53790 395 31643142
Graft versus host disease 37.18 10.80 65 53742 10382 31633155
Aplasia 36.10 10.80 40 53767 4163 31639374
Intentional product misuse 35.82 10.80 10 53797 37941 31605596
Lung disorder 35.37 10.80 128 53679 32184 31611353
Herpes simplex 35.22 10.80 44 53763 5201 31638336
Thrombotic microangiopathy 34.35 10.80 59 53748 9292 31634245
Septic shock 33.83 10.80 210 53597 65948 31577589
Graft versus host disease in gastrointestinal tract 33.19 10.80 35 53772 3444 31640093
Bradycardia 32.46 10.80 42 53765 69285 31574252
Eosinophilia 31.54 10.80 99 53708 23154 31620383
Depression 30.57 10.80 68 53739 90747 31552790
Pulmonary sarcoidosis 30.42 10.80 16 53791 533 31643004
International normalised ratio increased 29.90 10.80 20 53787 45203 31598334
Congenital herpes simplex infection 29.65 10.80 8 53799 35 31643502
Parainfluenzae virus infection 29.57 10.80 28 53779 2421 31641116
Differentiation syndrome 29.49 10.80 21 53786 1214 31642323
Confusional state 29.49 10.80 351 53456 132983 31510554
Lymphopenia 29.40 10.80 71 53736 14258 31629279
Purpura 29.40 10.80 56 53751 9554 31633983
Pericarditis 29.38 10.80 55 53752 9261 31634276
Drug hypersensitivity 28.18 10.80 50 53757 72549 31570988
Neutrophil count decreased 28.08 10.80 154 53653 46240 31597297
Mucosal inflammation 27.76 10.80 124 53683 34303 31609234
Wrong technique in product usage process 27.60 10.80 11 53796 33332 31610205
Squamous cell carcinoma 27.48 10.80 58 53749 10653 31632884
Rhabdomyolysis 27.29 10.80 41 53766 63540 31579997
Inappropriate schedule of product administration 26.80 10.80 28 53779 50795 31592742
Eosinophilic colitis 26.59 10.80 11 53796 209 31643328
Plasma cell myeloma recurrent 26.48 10.80 33 53774 3891 31639646
Encephalitis 26.36 10.80 44 53763 6771 31636766
Rash 26.26 10.80 484 53323 201002 31442535
Conjunctival irritation 26.15 10.80 9 53798 100 31643437
Drug resistance 25.74 10.80 93 53714 23360 31620177
Infective exacerbation of chronic obstructive airways disease 25.49 10.80 22 53785 1686 31641851
Delirium 25.41 10.80 138 53669 41283 31602254
Death 25.16 10.80 446 53361 360123 31283414
Rhinovirus infection 24.49 10.80 30 53777 3475 31640062
Varicella zoster virus infection 24.49 10.80 21 53786 1595 31641942
Aggression 23.97 10.80 17 53790 37274 31606263
Myocardial infarction 23.97 10.80 105 53702 113349 31530188
Immune effector cell-associated neurotoxicity syndrome 23.76 10.80 25 53782 2454 31641083
Hyperuricaemia 23.57 10.80 44 53763 7394 31636143
Hallucination 23.52 10.80 147 53660 46263 31597274
Escherichia sepsis 23.38 10.80 32 53775 4135 31639402
Drug dependence 23.16 10.80 5 53802 22574 31620963
Pain 22.77 10.80 205 53602 186554 31456983
Stress 22.75 10.80 7 53800 24934 31618603
Psychiatric symptom 22.59 10.80 28 53779 3283 31640254
Anxiety 22.58 10.80 79 53728 90954 31552583
Ichthyosis 22.54 10.80 8 53799 98 31643439
Cardiac arrest 22.28 10.80 77 53730 88985 31554552
Human herpesvirus 6 encephalitis 22.06 10.80 10 53797 239 31643298
Full blood count decreased 22.04 10.80 70 53737 16470 31627067
Injection site pain 21.99 10.80 16 53791 34618 31608919
Blood pressure increased 21.91 10.80 66 53741 79567 31563970
Bronchopneumopathy 21.82 10.80 12 53795 438 31643099
Drug withdrawal syndrome 21.75 10.80 3 53804 18747 31624790
Genital erythema 21.33 10.80 9 53798 180 31643357
Hyperleukocytosis 21.32 10.80 20 53787 1709 31641828
Respiratory tract infection 21.32 10.80 72 53735 17489 31626048
Nocardiosis 21.31 10.80 28 53779 3479 31640058
Respiratory arrest 21.19 10.80 9 53798 26248 31617289
Ophthalmic herpes zoster 21.17 10.80 15 53792 860 31642677
Angina pectoris 21.13 10.80 12 53795 29629 31613908
Hepatitis cholestatic 21.07 10.80 41 53766 7105 31636432
Botryomycosis 20.96 10.80 6 53801 34 31643503
Blood creatinine abnormal 20.80 10.80 22 53785 2172 31641365
Hypogammaglobulinaemia 20.74 10.80 39 53768 6588 31636949
Tumour flare 20.71 10.80 14 53793 744 31642793
Hallucination, visual 20.28 10.80 66 53741 15728 31627809
Hypercalcaemia 20.28 10.80 61 53746 13939 31629598
Malignant neoplasm of unknown primary site 20.26 10.80 11 53796 391 31643146
Diffuse large B-cell lymphoma 20.12 10.80 45 53762 8596 31634941
Respiratory tract infection bacterial 20.11 10.80 18 53789 1448 31642089
Infection 19.57 10.80 219 53588 81712 31561825
Malignant neoplasm progression 19.29 10.80 69 53738 78929 31564608
Escherichia infection 19.26 10.80 40 53767 7264 31636273
JC virus infection 18.92 10.80 20 53787 1974 31641563
Glomerulosclerosis 18.80 10.80 13 53794 717 31642820
Polymyositis 18.67 10.80 17 53790 1398 31642139
Influenza 18.61 10.80 134 53673 44191 31599346
Hyperhidrosis 18.43 10.80 56 53751 67337 31576200
Musculoskeletal stiffness 18.36 10.80 26 53781 41299 31602238
Atrial fibrillation 18.33 10.80 283 53524 113500 31530037
Escherichia bacteraemia 18.30 10.80 24 53783 2977 31640560
Aplastic anaemia 18.24 10.80 45 53762 9158 31634379
Logorrhoea 18.10 10.80 21 53786 2298 31641239
Laryngeal cancer metastatic 18.09 10.80 6 53801 59 31643478
Monoclonal immunoglobulin present 18.08 10.80 14 53793 920 31642617
Morganella infection 18.03 10.80 11 53796 489 31643048
Mixed liver injury 17.97 10.80 21 53786 2316 31641221
Herpes ophthalmic 17.89 10.80 11 53796 496 31643041
Lymphocytic infiltration 17.86 10.80 12 53795 631 31642906
Toxic neuropathy 17.81 10.80 11 53796 500 31643037
Haemorrhoids thrombosed 17.77 10.80 8 53799 188 31643349
Coronary artery disease 17.65 10.80 32 53775 46055 31597482
Rheumatoid arthritis 17.60 10.80 34 53773 47775 31595762
Bacillus bacteraemia 17.57 10.80 6 53801 65 31643472
Acute HIV infection 17.49 10.80 6 53801 66 31643471
SARS-CoV-2 sepsis 17.42 10.80 7 53800 123 31643414
Brief psychotic disorder with marked stressors 17.17 10.80 8 53799 204 31643333
Positive end-expiratory pressure 17.14 10.80 4 53803 8 31643529
Blood creatine phosphokinase increased 17.12 10.80 28 53779 41946 31601591
Pneumonia fungal 17.09 10.80 35 53772 6294 31637243
Therapeutic product effect incomplete 17.04 10.80 30 53777 43666 31599871
Respiratory tract infection viral 17.01 10.80 19 53788 1995 31641542
Hyperbilirubinaemia 16.90 10.80 62 53745 15688 31627849
Hyperthermia 16.83 10.80 46 53761 9958 31633579
Vaccination failure 16.73 10.80 13 53794 859 31642678
Dyscalculia 16.72 10.80 6 53801 76 31643461
Myositis 16.70 10.80 49 53758 11045 31632492
Viral mutation identified 16.66 10.80 22 53785 2747 31640790
Incorrect disposal of product 16.60 10.80 9 53798 319 31643218
Basal cell carcinoma 16.60 10.80 68 53739 18111 31625426
Aspergillus infection 16.48 10.80 50 53757 11478 31632059
CSF cell count increased 16.44 10.80 5 53802 36 31643501
Lymphocyte count decreased 16.36 10.80 74 53733 20575 31622962
Periorbital cellulitis 16.26 10.80 8 53799 231 31643306
Fluid imbalance 16.16 10.80 8 53799 234 31643303
Herpes virus infection 16.00 10.80 21 53786 2606 31640931
Mutism 15.86 10.80 12 53795 762 31642775
Stomatitis 15.85 10.80 118 53689 39320 31604217
Citrobacter infection 15.79 10.80 10 53797 475 31643062
Chest pain 15.76 10.80 125 53682 116832 31526705
Acute myocardial infarction 15.55 10.80 40 53767 50783 31592754
Disseminated cryptococcosis 15.38 10.80 15 53792 1345 31642192
Hypercapnic coma 15.34 10.80 7 53800 170 31643367
Renal disorder 15.33 10.80 80 53727 23565 31619972
Respiratory depression 15.32 10.80 3 53804 14507 31629030
Complications of transplanted heart 15.31 10.80 8 53799 263 31643274
Haemophagocytic lymphohistiocytosis 15.17 10.80 49 53758 11629 31631908
Pneumonia pneumococcal 15.16 10.80 17 53790 1792 31641745
Sepsis 15.16 10.80 351 53456 151578 31491959
Graft versus host disease in lung 15.14 10.80 10 53797 511 31643026
Herpes zoster reactivation 15.09 10.80 8 53799 271 31643266
Melaena 15.06 10.80 20 53787 32634 31610903
Aeromonas infection 14.98 10.80 8 53799 275 31643262
Cytomegalovirus infection 14.93 10.80 82 53725 24625 31618912
Bronchial haemorrhage 14.80 10.80 11 53796 680 31642857
Gastrointestinal haemorrhage 14.76 10.80 81 53726 82468 31561069
Haematochezia 14.70 10.80 29 53778 40435 31603102
Bacterial sepsis 14.60 10.80 28 53779 4800 31638737
Myelodysplastic syndrome 14.52 10.80 68 53739 19183 31624354
Haemolytic anaemia 14.49 10.80 43 53764 9753 31633784
Pityriasis rubra pilaris 14.36 10.80 6 53801 117 31643420
Dermatitis exfoliative 14.22 10.80 33 53774 6459 31637078
Cerebellar syndrome 14.17 10.80 18 53789 2163 31641374
Depressed level of consciousness 14.13 10.80 113 53694 38488 31605049
Disorientation 14.11 10.80 95 53712 30649 31612888
Contraindicated product administered 14.10 10.80 8 53799 19764 31623773
Blood osmolarity abnormal 14.07 10.80 3 53804 3 31643534
Herpes zoster oticus 14.04 10.80 6 53801 124 31643413
Amyotrophy 13.98 10.80 9 53798 440 31643097
Retinal detachment 13.97 10.80 28 53779 4958 31638579
Dermatitis bullous 13.96 10.80 32 53775 6213 31637324
Venous thrombosis 13.93 10.80 22 53785 3233 31640304
Hemiparesis 13.91 10.80 4 53803 14890 31628647
Enterococcal sepsis 13.88 10.80 15 53792 1518 31642019
Loss of consciousness 13.78 10.80 76 53731 77279 31566258
Donor leukocyte infusion 13.78 10.80 4 53803 24 31643513
Wheezing 13.76 10.80 25 53782 35961 31607576
Folliculitis 13.72 10.80 25 53782 4123 31639414
Adverse drug reaction 13.50 10.80 81 53726 25120 31618417
Abdominal pain 13.41 10.80 171 53636 145781 31497756
Benign neoplasm of skin 13.35 10.80 5 53802 72 31643465
Flushing 13.34 10.80 19 53788 30109 31613428
Arthralgia 13.33 10.80 179 53628 151245 31492292
Aphasia 13.31 10.80 68 53739 19863 31623674
Myoclonus 13.30 10.80 53 53754 13937 31629600
CSF volume increased 13.25 10.80 4 53803 28 31643509
Cerebrovascular accident 13.14 10.80 80 53727 79404 31564133
Chronic kidney disease 13.13 10.80 28 53779 37947 31605590
Facial paralysis 13.11 10.80 42 53765 9927 31633610
Bacteraemia 13.09 10.80 62 53745 17572 31625965
Metabolic acidosis 13.01 10.80 30 53777 39547 31603990
Pneumonia haemophilus 12.99 10.80 8 53799 362 31643175
Lymphocytosis 12.94 10.80 17 53790 2112 31641425
Macular fibrosis 12.85 10.80 8 53799 369 31643168
Pneumocystis jirovecii pneumonia 12.71 10.80 63 53744 18188 31625349
Injury 12.65 10.80 9 53798 19700 31623837
Renal tubular disorder 12.64 10.80 25 53782 4385 31639152
Blood glucose increased 12.60 10.80 57 53750 61026 31582511
Oesophagitis 12.59 10.80 48 53759 12368 31631169
Haematemesis 12.57 10.80 15 53792 25638 31617899
Renal ischaemia 12.46 10.80 9 53798 532 31643005
Lactic acidosis 12.38 10.80 22 53785 31915 31611622
Mixed dementia 12.37 10.80 7 53800 270 31643267
Sleep disorder 12.29 10.80 16 53791 26332 31617205
Product quality issue 12.25 10.80 6 53801 16105 31627432
Streptococcal bacteraemia 12.19 10.80 15 53792 1745 31641792
Pulmonary sepsis 12.13 10.80 16 53791 1996 31641541
Oral herpes 12.05 10.80 26 53781 4847 31638690
Plasmacytoma 12 10.80 21 53786 3356 31640181
Bladder cancer 11.95 10.80 5 53802 14720 31628817
Psoriasis 11.94 10.80 40 53767 46679 31596858
Oral mucosal erythema 11.94 10.80 8 53799 419 31643118
Lymphocytic lymphoma 11.91 10.80 4 53803 41 31643496
Wrong strength 11.85 10.80 5 53802 100 31643437
Diabetic ketoacidosis 11.83 10.80 7 53800 16898 31626639
Pulmonary hypertension 11.78 10.80 10 53797 20031 31623506
Serum sickness 11.78 10.80 15 53792 1807 31641730
Retinitis 11.77 10.80 7 53800 297 31643240
Gastric varices 11.77 10.80 8 53799 429 31643108
Pneumonia viral 11.76 10.80 19 53788 2845 31640692
Fall 11.74 10.80 234 53573 185855 31457682
Rash erythematous 11.66 10.80 72 53735 22555 31620982
Cardiac failure congestive 11.56 10.80 83 53724 79304 31564233
Medication error 11.50 10.80 13 53794 22759 31620778
Serotonin syndrome 11.49 10.80 9 53798 18764 31624773
Feeding disorder 11.38 10.80 30 53777 6356 31637181
Peripheral T-cell lymphoma unspecified recurrent 11.34 10.80 4 53803 48 31643489
Anti-cyclic citrullinated peptide antibody positive 11.32 10.80 13 53794 1407 31642130
Blood creatinine increased 11.22 10.80 213 53594 88865 31554672
Colitis 11.22 10.80 97 53710 33790 31609747
Pulmonary congestion 11.22 10.80 4 53803 12979 31630558
Hospitalisation 11.18 10.80 45 53762 49762 31593775
Hypereosinophilic syndrome 11.14 10.80 6 53801 210 31643327
Pseudomonal bacteraemia 11.12 10.80 12 53795 1212 31642325
Haemorrhage 11.12 10.80 42 53765 47292 31596245
T-cell prolymphocytic leukaemia 11.05 10.80 4 53803 52 31643485
Sopor 10.98 10.80 3 53804 11549 31631988
Axonal neuropathy 10.97 10.80 11 53796 1020 31642517
Platelet disorder 10.83 10.80 13 53794 1474 31642063
Renal failure 10.81 10.80 280 53527 123050 31520487

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 585.69 9.89 1042 99348 203276 70624778
Neurotoxicity 405.70 9.89 337 100053 29489 70798565
Cytokine release syndrome 357.79 9.89 298 100092 26169 70801885
Acute kidney injury 352.98 9.89 1466 98924 473158 70354896
Neutropenia 283.85 9.89 904 99486 256252 70571802
Toxic encephalopathy 280.44 9.89 178 100212 10228 70817826
Encephalopathy 278.61 9.89 388 100002 61273 70766781
Plasma cell myeloma 273.37 9.89 421 99969 72780 70755274
Drug reaction with eosinophilia and systemic symptoms 266.53 9.89 368 100022 57645 70770409
Hepatocellular injury 251.28 9.89 318 100072 45773 70782281
Toxic skin eruption 243.86 9.89 213 100177 19949 70808105
Thrombocytopenia 242.62 9.89 817 99573 238293 70589761
Pyrexia 240.75 9.89 1574 98816 605378 70222676
Agranulocytosis 240.53 9.89 291 100099 40007 70788047
Altered state of consciousness 235.62 9.89 287 100103 39735 70788319
Herpes zoster 235.10 9.89 428 99962 84807 70743247
Completed suicide 202.74 9.89 38 100352 227097 70600957
Rash maculo-papular 189.07 9.89 291 100099 50254 70777800
Pancytopenia 179.22 9.89 545 99845 150562 70677492
Dyslalia 176.71 9.89 63 100327 951 70827103
Drug ineffective 175.07 9.89 712 99678 939040 69889014
Febrile bone marrow aplasia 174.58 9.89 141 100249 11850 70816204
Drug abuse 171.34 9.89 9 100381 147247 70680807
Acute generalised exanthematous pustulosis 170.97 9.89 155 100235 15242 70812812
Rheumatoid arthritis 170.25 9.89 101 100289 291704 70536350
Dysarthria 168.12 9.89 310 100080 62003 70766051
Synovitis 146.95 9.89 9 100381 129219 70698835
Contraindicated product administered 135.04 9.89 16 100374 134596 70693458
Nervous system disorder 127.47 9.89 164 100226 23982 70804072
Herpes simplex 120.66 9.89 111 100279 11121 70816933
Toxicity to various agents 119.05 9.89 225 100165 381947 70446107
Drug hypersensitivity 117.33 9.89 119 100271 262340 70565714
Ophthalmic herpes simplex 111.57 9.89 41 100349 678 70827376
Dermatitis exfoliative generalised 109.78 9.89 83 100307 6331 70821723
Bronchopulmonary aspergillosis 108.29 9.89 141 100249 20861 70807193
Oral herpes 105.92 9.89 150 100240 24036 70804018
Pemphigus 103.59 9.89 3 100387 83033 70745021
Cholestasis 103.45 9.89 217 100173 47655 70780399
Intentional overdose 100.48 9.89 11 100379 98424 70729630
Joint swelling 99.90 9.89 127 100263 253084 70574970
Tumour lysis syndrome 98.80 9.89 136 100254 21224 70806830
Drug intolerance 97.84 9.89 105 100285 225582 70602472
Septic shock 91.90 9.89 358 100032 111900 70716154
Hepatic cytolysis 89.98 9.89 123 100267 19069 70808985
Pneumonia 88.61 9.89 1257 99133 594975 70233079
Neuropathy peripheral 86.85 9.89 383 100007 126513 70701541
Systemic lupus erythematosus 84.79 9.89 20 100370 101882 70726172
Therapeutic product effect decreased 84.03 9.89 49 100341 142969 70685085
Drug interaction 81.77 9.89 272 100118 381169 70446885
Lymphopenia 81.29 9.89 142 100248 27217 70800837
Arthropathy 80.53 9.89 57 100333 150000 70678054
Platelet count decreased 80.04 9.89 478 99912 177744 70650310
Squamous cell carcinoma of skin 79.44 9.89 94 100296 12618 70815436
Pathogen resistance 79.38 9.89 96 100294 13183 70814871
Eosinophilia 79.36 9.89 176 100214 40143 70787911
Swelling 77.03 9.89 92 100298 188447 70639607
Glossodynia 75.98 9.89 15 100375 86472 70741582
Wound 75.31 9.89 23 100367 98709 70729345
Aplasia 74.68 9.89 70 100320 7181 70820873
White blood cell count decreased 69.89 9.89 446 99944 169695 70658359
Acute myeloid leukaemia 67.71 9.89 141 100249 30799 70797255
Herpes virus infection 66.73 9.89 63 100327 6521 70821533
Cytopenia 65.12 9.89 100 100290 17223 70810831
Microsporidia infection 62.97 9.89 29 100361 869 70827185
Hallucination 62.23 9.89 243 100147 76017 70752037
Anti-cyclic citrullinated peptide antibody positive 62.01 9.89 12 100378 70173 70757881
Suicide attempt 61.59 9.89 18 100372 79492 70748562
Alopecia 61.58 9.89 117 100273 198373 70629681
Hallucination, visual 61.08 9.89 131 100259 29206 70798848
Immune effector cell-associated neurotoxicity syndrome 60.51 9.89 48 100342 3930 70824124
Blood urea increased 60.47 9.89 172 100218 45737 70782317
Pain 60.42 9.89 584 99806 628232 70199822
Laryngitis fungal 58.88 9.89 17 100373 123 70827931
Human herpesvirus 6 encephalitis 57.82 9.89 23 100367 476 70827578
Helicobacter infection 57.35 9.89 6 100384 55650 70772404
Blood creatinine increased 56.96 9.89 372 100018 142629 70685425
Genital herpes 56.10 9.89 35 100355 1950 70826104
Treatment failure 56.08 9.89 73 100317 144069 70683985
Arthralgia 55.13 9.89 452 99938 502938 70325116
COVID-19 54.93 9.89 295 100095 105462 70722592
Chronic lymphocytic leukaemia 54.08 9.89 53 100337 5745 70822309
Abdominal discomfort 53.95 9.89 142 100248 214516 70613538
Depressed level of consciousness 53.93 9.89 256 100134 87175 70740879
Confusional state 52.77 9.89 625 99765 283773 70544281
Encephalitis cytomegalovirus 52.64 9.89 27 100363 1029 70827025
Duodenal ulcer perforation 51.43 9.89 6 100384 51106 70776948
Graft versus host disease in gastrointestinal tract 51.14 9.89 52 100338 5892 70822162
Graft versus host disease 49.96 9.89 82 100308 14941 70813113
Pseudomonas infection 49.33 9.89 93 100297 18901 70809153
Demodicidosis 48.69 9.89 15 100375 139 70827915
Rectal prolapse 48.02 9.89 32 100358 1997 70826057
Face oedema 47.20 9.89 109 100281 25530 70802524
Bacterial sepsis 46.88 9.89 56 100334 7591 70820463
Musculoskeletal stiffness 46.79 9.89 86 100304 147674 70680380
Myoclonus 46.29 9.89 110 100280 26245 70801809
Renal disorder 45.83 9.89 138 100252 37871 70790183
Bradycardia 44.59 9.89 67 100323 124548 70703506
Sepsis 44.28 9.89 535 99855 244010 70584044
Delirium 44.23 9.89 216 100174 74398 70753656
Discomfort 43.52 9.89 51 100339 105385 70722669
Rheumatoid factor positive 43.34 9.89 8 100382 48392 70779662
Neutrophil count decreased 43.33 9.89 233 100157 83323 70744731
Renal tubular disorder 41.22 9.89 47 100343 6063 70821991
Cytomegalovirus infection 40.32 9.89 136 100254 39622 70788432
Drug resistance 39.94 9.89 132 100258 38058 70789996
Thrombotic microangiopathy 39.83 9.89 82 100308 17766 70810288
Hypoglycaemia 39.64 9.89 45 100345 94319 70733735
Maternal exposure during pregnancy 39.37 9.89 64 100326 115281 70712773
Mobility decreased 39.20 9.89 53 100337 102946 70725108
International normalised ratio increased 39.08 9.89 34 100356 80692 70747362
Dyspnoea 38.99 9.89 813 99577 769247 70058807
Hypersensitivity 38.87 9.89 180 100210 229632 70598422
Mixed liver injury 38.70 9.89 46 100344 6203 70821851
Escherichia bacteraemia 37.67 9.89 44 100346 5825 70822229
Bladder prolapse 37.48 9.89 23 100367 1244 70826810
Plasma cell myeloma recurrent 37.35 9.89 38 100352 4308 70823746
Ophthalmic herpes zoster 37.02 9.89 29 100361 2331 70825723
Pneumocystis jirovecii pneumonia 37.01 9.89 110 100280 29972 70798082
Injection site inflammation 36.97 9.89 34 100356 3404 70824650
Therapeutic product effect incomplete 36.87 9.89 71 100319 119811 70708243
Hepatitis cholestatic 36.72 9.89 65 100325 12585 70815469
Vocal cord dysfunction 35.81 9.89 16 100374 446 70827608
Hyperuricaemia 33.99 9.89 58 100332 10908 70817146
Pain in extremity 33.87 9.89 299 100091 327783 70500271
Cerebral toxoplasmosis 33.58 9.89 26 100364 2054 70826000
Nephritis allergic 33.43 9.89 17 100373 636 70827418
Psychiatric symptom 33.31 9.89 44 100346 6600 70821454
Impaired healing 32.87 9.89 34 100356 74340 70753714
Disorientation 32.42 9.89 165 100225 57758 70770296
Tumour flare 32.10 9.89 19 100371 962 70827092
Wrong technique in product usage process 31.98 9.89 30 100360 68668 70759386
Drug dependence 31.69 9.89 7 100383 37314 70790740
Deep vein thrombosis 31.19 9.89 266 100124 110776 70717278
Intentional self-injury 31.14 9.89 4 100386 31646 70796408
Aspergillus infection 30.75 9.89 74 100316 17794 70810260
Mucosal inflammation 30.43 9.89 182 100208 67668 70760386
Cardiac arrest 30.20 9.89 120 100270 159714 70668340
Rhabdomyolysis 30.07 9.89 56 100334 95704 70732350
Varicella zoster virus infection 30.03 9.89 33 100357 4087 70823967
Rhinovirus infection 29.83 9.89 42 100348 6691 70821363
Hyperthermia 29.73 9.89 70 100320 16601 70811453
Renal failure 29.70 9.89 403 99987 188667 70639387
Red blood cell sedimentation rate increased 29.46 9.89 9 100381 38633 70789421
Death 29.26 9.89 527 99863 509534 70318520
Dermatitis exfoliative 29.08 9.89 53 100337 10498 70817556
Squamous cell carcinoma 29.01 9.89 64 100326 14540 70813514
Escherichia sepsis 28.99 9.89 44 100346 7499 70820555
Encephalitis 28.66 9.89 61 100329 13524 70814530
COVID-19 pneumonia 28.62 9.89 82 100308 21887 70806167
Serotonin syndrome 28.38 9.89 12 100378 42102 70785952
Haemophagocytic lymphohistiocytosis 28.32 9.89 76 100314 19536 70808518
Lung disorder 27.79 9.89 181 100209 69303 70758751
Irritable bowel syndrome 27.68 9.89 19 100371 50831 70777223
C-reactive protein abnormal 27.64 9.89 10 100380 38569 70789485
Eosinophilic colitis 27.38 9.89 13 100377 418 70827636
Hypogammaglobulinaemia 26.92 9.89 54 100336 11484 70816570
Speech disorder 26.87 9.89 142 100248 50438 70777616
Genital herpes simplex 26.84 9.89 12 100378 335 70827719
CSF cell count increased 26.76 9.89 9 100381 113 70827941
Lymphocyte count decreased 26.48 9.89 127 100263 43412 70784642
Sopor 26.27 9.89 6 100384 31261 70796793
Conjunctival irritation 25.80 9.89 9 100381 127 70827927
Restlessness 25.71 9.89 123 100267 42005 70786049
Differentiation syndrome 25.69 9.89 23 100367 2224 70825830
Osteoarthritis 25.43 9.89 41 100349 74106 70753948
Purpura 25.29 9.89 69 100321 17906 70810148
Psoriatic arthropathy 24.98 9.89 33 100357 64738 70763316
Genital erythema 24.20 9.89 10 100380 229 70827825
Musculoskeletal pain 24.03 9.89 58 100332 90269 70737785
Peripheral swelling 23.78 9.89 217 100173 236346 70591708
Intentional product misuse 23.73 9.89 48 100342 79547 70748507
Toxic erythema of chemotherapy 23.69 9.89 10 100380 242 70827812
Hyperbilirubinaemia 23.59 9.89 78 100312 22490 70805564
Pulmonary sarcoidosis 23.52 9.89 17 100373 1210 70826844
Blood glucose increased 23.01 9.89 72 100318 102910 70725144
Viral mutation identified 22.99 9.89 27 100363 3595 70824459
Laryngeal stenosis 22.90 9.89 15 100375 909 70827145
Bacteraemia 22.77 9.89 92 100298 29217 70798837
Cerebellar stroke 22.54 9.89 12 100378 494 70827560
Fall 22.35 9.89 469 99921 443627 70384427
Respiratory arrest 22.35 9.89 26 100364 53907 70774147
Product use issue 22.26 9.89 156 100234 179781 70648273
Mucosal excoriation 22.25 9.89 4 100386 0 70828054
Sedation 22.23 9.89 20 100370 46711 70781343
Hyperleukocytosis 22.19 9.89 21 100369 2180 70825874
Herpes ophthalmic 21.99 9.89 17 100373 1340 70826714
Eye infection toxoplasmal 21.81 9.89 12 100378 528 70827526
Metastases to liver 21.68 9.89 5 100385 25873 70802181
Infective exacerbation of chronic obstructive airways disease 21.66 9.89 22 100368 2489 70825565
Atrial fibrillation 21.64 9.89 374 100016 183974 70644080
Ichthyosis 21.62 9.89 8 100382 135 70827919
Terminal ileitis 21.61 9.89 13 100377 678 70827376
Acute pulmonary oedema 21.44 9.89 54 100336 13358 70814696
Aplastic anaemia 21.40 9.89 62 100328 16654 70811400
Serum sickness 21.36 9.89 25 100365 3316 70824738
Diarrhoea 21.36 9.89 1332 99058 782009 70046045
Cell death 21.34 9.89 28 100362 4172 70823882
Nocardiosis 21.26 9.89 31 100359 5098 70822956
Fibromyalgia 21.02 9.89 22 100368 47852 70780202
Malignant neoplasm of unknown primary site 21.02 9.89 13 100377 713 70827341
Haemorrhoids thrombosed 21.02 9.89 9 100381 226 70827828
Anaphylactic reaction 20.86 9.89 47 100343 74927 70753127
Streptococcal bacteraemia 20.84 9.89 24 100366 3129 70824925
Obesity 20.84 9.89 6 100384 26765 70801289
Contusion 20.63 9.89 102 100288 127934 70700120
Hepatic enzyme increased 20.47 9.89 134 100256 156856 70671198
Venoocclusive liver disease 20.32 9.89 46 100344 10632 70817422
Blood lactate dehydrogenase increased 20.32 9.89 101 100289 35026 70793028
Respiratory tract infection bacterial 20.29 9.89 18 100372 1719 70826335
Eye infection bacterial 20.11 9.89 9 100381 252 70827802
Parainfluenzae virus infection 20.05 9.89 30 100360 5050 70823004
Dermatitis bullous 20.02 9.89 51 100339 12706 70815348
Injection site pain 19.94 9.89 92 100298 117527 70710527
Epstein-Barr virus infection 19.92 9.89 52 100338 13146 70814908
Renal impairment 19.88 9.89 300 100090 143637 70684417
Drug withdrawal syndrome 19.50 9.89 11 100379 32704 70795350
Vaccination failure 19.47 9.89 16 100374 1377 70826677
Pancreatitis acute 19.44 9.89 120 100270 45104 70782950
Coronary artery disease 19.42 9.89 37 100353 62699 70765355
Cerebellar syndrome 19.38 9.89 30 100360 5201 70822853
Bronchopneumopathy 19.18 9.89 12 100378 672 70827382
Fungal endocarditis 19.10 9.89 11 100379 529 70827525
Pneumonia fungal 19.08 9.89 43 100347 9910 70818144
Asthma 19.02 9.89 97 100293 120696 70707358
Acute HIV infection 18.98 9.89 6 100384 61 70827993
Hip arthroplasty 18.88 9.89 8 100382 28032 70800022
Myocardial infarction 18.78 9.89 154 100236 171491 70656563
Acute febrile neutrophilic dermatosis 18.72 9.89 24 100366 3495 70824559
Axonal neuropathy 18.56 9.89 18 100372 1926 70826128
Colitis 18.51 9.89 154 100236 63660 70764394
SARS-CoV-2 sepsis 18.50 9.89 7 100383 126 70827928
Skin lesion 18.43 9.89 105 100285 38355 70789699
Post herpetic neuralgia 18.29 9.89 20 100370 2464 70825590
Foreign body in reproductive tract 17.75 9.89 10 100380 461 70827593
Full blood count decreased 17.73 9.89 74 100316 23844 70804210
Campylobacter colitis 17.59 9.89 5 100385 34 70828020
Product tampering 17.58 9.89 8 100382 233 70827821
Lower respiratory tract infection 17.54 9.89 90 100300 111823 70716231
Glomerulosclerosis 17.51 9.89 13 100377 964 70827090
Myelodysplastic syndrome 17.48 9.89 86 100304 29699 70798355
Metastases to bone 17.44 9.89 5 100385 22371 70805683
Graft versus host disease in lung 17.19 9.89 12 100378 808 70827246
Urine output decreased 17.16 9.89 58 100332 16912 70811142
Knee arthroplasty 17.15 9.89 14 100376 34287 70793767
Neutropenic colitis 17.12 9.89 28 100362 5086 70822968
Mucormycosis 16.92 9.89 36 100354 7978 70820076
Muscle rigidity 16.88 9.89 3 100387 18647 70809407
Enteritis 16.82 9.89 48 100342 12783 70815271
Acute lymphocytic leukaemia 16.75 9.89 29 100361 5516 70822538
Haemolytic anaemia 16.63 9.89 57 100333 16737 70811317
Gastrointestinal disorder 16.40 9.89 85 100305 105342 70722712
Arthritis 16.39 9.89 77 100313 97903 70730151
Angina pectoris 16.36 9.89 27 100363 48356 70779698
Lactic acidosis 16.32 9.89 43 100347 64981 70763073
Brief psychotic disorder with marked stressors 16.22 9.89 8 100382 280 70827774
Bicytopenia 16.20 9.89 24 100366 4004 70824050
Posterior reversible encephalopathy syndrome 16.18 9.89 73 100317 24329 70803725
Morganella infection 16.13 9.89 13 100377 1089 70826965
Gastrointestinal haemorrhage 16.09 9.89 121 100269 137287 70690767
Peripheral T-cell lymphoma unspecified recurrent 16.07 9.89 5 100385 48 70828006
Labelled drug-drug interaction medication error 16.06 9.89 7 100383 24120 70803934
Disseminated cryptococcosis 16.05 9.89 16 100374 1771 70826283
Pseudomonal bacteraemia 16.04 9.89 19 100371 2553 70825501
Cardiac failure congestive 15.99 9.89 119 100271 135338 70692716
Biopsy skin abnormal 15.98 9.89 7 100383 186 70827868
Laryngeal cancer metastatic 15.89 9.89 5 100385 50 70828004
Loss of personal independence in daily activities 15.87 9.89 64 100326 84846 70743208
Logorrhoea 15.82 9.89 24 100366 4090 70823964
Pneumonia influenzal 15.81 9.89 19 100371 2591 70825463
Rash morbilliform 15.80 9.89 28 100362 5427 70822627
Diffuse large B-cell lymphoma 15.75 9.89 48 100342 13254 70814800
Aphasia 15.70 9.89 110 100280 43139 70784915
Blister 15.67 9.89 81 100309 100445 70727609
Meningoencephalitis herpetic 15.66 9.89 16 100374 1823 70826231
Rash erythematous 15.64 9.89 126 100264 51592 70776462
Weight increased 15.61 9.89 245 100145 242086 70585968
Extrapyramidal disorder 15.52 9.89 5 100385 20745 70807309
Amyotrophy 15.51 9.89 10 100380 590 70827464
Bacterial vaginosis 15.50 9.89 12 100378 948 70827106
Venoocclusive disease 15.44 9.89 24 100366 4176 70823878
Device malfunction 15.37 9.89 4 100386 19080 70808974
Neuropsychiatric syndrome 15.37 9.89 6 100384 118 70827936
Depression 15.36 9.89 194 100196 198780 70629274
Erythema multiforme 15.35 9.89 55 100335 16509 70811545
Complications of transplanted heart 15.33 9.89 8 100382 316 70827738
Limbic encephalitis 15.32 9.89 11 100379 775 70827279
Rash vesicular 15.31 9.89 27 100363 5213 70822841
Actinic keratosis 15.30 9.89 28 100362 5562 70822492
Blood cholesterol increased 15.27 9.89 44 100346 64560 70763494
Pityriasis rubra pilaris 15.23 9.89 6 100384 121 70827933
Wheezing 15.18 9.89 75 100315 94095 70733959
Joint range of motion decreased 15.16 9.89 9 100381 26017 70802037
Bone marrow failure 15.15 9.89 120 100270 48890 70779164
Botryomycosis 15.15 9.89 5 100385 59 70827995
Neurological symptom 15.13 9.89 33 100357 7440 70820614
Portal vein cavernous transformation 15.09 9.89 6 100384 124 70827930
Cytomegalovirus chorioretinitis 15.09 9.89 27 100363 5271 70822783
Bacillus bacteraemia 15.05 9.89 6 100384 125 70827929
Blood creatine phosphokinase increased 15.01 9.89 41 100349 61222 70766832
Neuralgia 14.98 9.89 80 100310 28523 70799531
Decreased appetite 14.82 9.89 549 99841 304231 70523823
Imperception 14.61 9.89 3 100387 3 70828051
Klebsiella sepsis 14.58 9.89 19 100371 2812 70825242
Pseudomyopia 14.57 9.89 5 100385 67 70827987
Enterococcal sepsis 14.50 9.89 18 100372 2539 70825515
Hypertension 14.47 9.89 314 100076 295719 70532335
Facial paralysis 14.46 9.89 61 100329 19747 70808307
Acute respiratory distress syndrome 14.43 9.89 104 100286 41150 70786904
Aeromonas infection 14.33 9.89 8 100382 362 70827692
Dyscalculia 14.30 9.89 5 100385 71 70827983
Nephropathy toxic 14.29 9.89 58 100332 18456 70809598
Crystalluria 14.26 9.89 11 100379 864 70827190
Cerebrovascular accident 14.23 9.89 132 100258 143338 70684716
Toxic neuropathy 14.23 9.89 11 100379 867 70827187
Acute myocardial infarction 14.22 9.89 54 100336 72833 70755221
Folliculitis 14.17 9.89 24 100366 42546 70785508
Escherichia infection 14.10 9.89 53 100337 16278 70811776
Flushing 14.09 9.89 64 100326 82108 70745946
Lymphocytosis 13.98 9.89 22 100368 3868 70824186
Body temperature decreased 13.97 9.89 12 100378 28660 70799394
Infective aneurysm 13.84 9.89 11 100379 903 70827151
Neurosis 13.72 9.89 8 100382 394 70827660
Incorrect disposal of product 13.70 9.89 11 100379 916 70827138
Herpes zoster oticus 13.64 9.89 8 100382 398 70827656
Hepatic cirrhosis 13.63 9.89 14 100376 30717 70797337
Infective chondritis 13.62 9.89 4 100386 31 70828023
Product administration error 13.61 9.89 13 100377 29510 70798544
Cyanosis 13.55 9.89 8 100382 23198 70804856
Vitiligo 13.50 9.89 15 100375 1880 70826174
Rhegmatogenous retinal detachment 13.44 9.89 6 100384 167 70827887
Tractional retinal detachment 13.42 9.89 5 100385 86 70827968
Plasmacytoma 13.31 9.89 22 100368 4032 70824022
Mixed dementia 13.27 9.89 7 100383 283 70827771
Haematemesis 13.24 9.89 31 100359 48766 70779288
Wrong strength 13.15 9.89 6 100384 176 70827878
Cytomegalovirus test positive 13.12 9.89 26 100364 5482 70822572
Soliloquy 13.11 9.89 9 100381 590 70827464
Campylobacter gastroenteritis 13.10 9.89 12 100378 1195 70826859
CSF volume increased 13.09 9.89 4 100386 36 70828018
Necrotising retinitis 13.07 9.89 12 100378 1199 70826855
Lymphocytic infiltration 13.04 9.89 13 100377 1439 70826615
Rash pustular 12.97 9.89 38 100352 10270 70817784
Varicella virus test positive 12.90 9.89 6 100384 184 70827870
Melaena 12.87 9.89 39 100351 56316 70771738
Persecutory delusion 12.84 9.89 23 100367 4494 70823560
Mycobacterial peritonitis 12.77 9.89 5 100385 99 70827955
Embedded device 12.77 9.89 18 100372 2871 70825183
Pneumocystis jirovecii infection 12.73 9.89 17 100373 2577 70825477
Acute lymphocytic leukaemia recurrent 12.72 9.89 24 100366 4880 70823174
Glossoptosis 12.69 9.89 6 100384 191 70827863
Condition aggravated 12.68 9.89 486 99904 427149 70400905
Blood pressure increased 12.68 9.89 189 100201 188328 70639726
Lymphocytic lymphoma 12.64 9.89 5 100385 102 70827952
Cytomegalovirus colitis 12.64 9.89 22 100368 4204 70823850
Laryngeal inflammation 12.64 9.89 6 100384 193 70827861
Gastrooesophageal reflux disease 12.63 9.89 76 100314 90763 70737291
Schizophrenia 12.61 9.89 4 100386 16764 70811290
Periorbital cellulitis 12.60 9.89 10 100380 819 70827235
Depressed mood 12.57 9.89 27 100363 43793 70784261
Cryopyrin associated periodic syndrome 12.55 9.89 6 100384 196 70827858
Peripheral T-cell lymphoma unspecified 12.55 9.89 10 100380 824 70827230
Benign neoplasm of skin 12.55 9.89 5 100385 104 70827950
Generalised tonic-clonic seizure 12.52 9.89 25 100365 41636 70786418
Malignant neoplasm progression 12.51 9.89 111 100279 121628 70706426
Hypercholesterolaemia 12.47 9.89 5 100385 18112 70809942
Pseudolymphoma 12.44 9.89 11 100379 1046 70827008
Klebsiella bacteraemia 12.42 9.89 17 100373 2637 70825417
Progressive multifocal leukoencephalopathy 12.38 9.89 57 100333 19157 70808897
Poriomania 12.33 9.89 6 100384 204 70827850
Accidental exposure to product 12.19 9.89 13 100377 28038 70800016
Thrombotic thrombocytopenic purpura 12.19 9.89 27 100363 6150 70821904
Citrobacter infection 12.16 9.89 10 100380 862 70827192
Respiratory tract infection 12.13 9.89 102 100288 42296 70785758
Injection site swelling 12.05 9.89 27 100363 43130 70784924
Pulmonary embolism 11.95 9.89 297 100093 155570 70672484
Venous thrombosis 11.94 9.89 28 100362 6621 70821433
Blood creatinine abnormal 11.93 9.89 22 100368 4397 70823657
Drug monitoring procedure not performed 11.92 9.89 10 100380 886 70827168
Peripheral nerve palsy 11.91 9.89 4 100386 50 70828004
Haematochezia 11.89 9.89 58 100332 73023 70755031
Medication error 11.87 9.89 41 100349 56871 70771183
Cryptosporidiosis infection 11.84 9.89 9 100381 692 70827362
Leukaemia recurrent 11.84 9.89 17 100373 2758 70825296
Platelet count increased 11.82 9.89 7 100383 20266 70807788
Gingival erosion 11.77 9.89 5 100385 123 70827931
Metabolic encephalopathy 11.66 9.89 32 100358 8331 70819723
Sleep disorder 11.64 9.89 55 100335 69817 70758237
Lichenification 11.62 9.89 9 100381 711 70827343
Poisoning 11.60 9.89 9 100381 22613 70805441
Exostosis 11.57 9.89 3 100387 14342 70813712
Fracture 11.47 9.89 7 100383 19937 70808117
Hypotension 11.46 9.89 462 99928 403919 70424135
Bone marrow necrosis 11.41 9.89 6 100384 241 70827813
Respiratory depression 11.37 9.89 11 100379 24820 70803234
Respiratory tract infection viral 11.33 9.89 19 100371 3522 70824532
Thermal burn 11.31 9.89 27 100363 6459 70821595
Cerebral thrombosis 11.30 9.89 15 100375 2261 70825793
Right ventricular failure 11.25 9.89 9 100381 22265 70805789
Blood pressure systolic abnormal 11.23 9.89 42 100348 12867 70815187
Rash 11.20 9.89 853 99537 509709 70318345
Hyperphosphataemia 11.18 9.89 21 100369 4255 70823799
Tri-iodothyronine free increased 11.05 9.89 6 100384 257 70827797
Ectropion 11.01 9.89 7 100383 403 70827651
Hypoglycaemic seizure 10.97 9.89 9 100381 773 70827281
Melanaemia 10.95 9.89 4 100386 65 70827989
Parkinsonism 10.93 9.89 4 100386 15321 70812733
Hypercapnic coma 10.92 9.89 7 100383 409 70827645
Erythema annulare 10.85 9.89 5 100385 150 70827904
Polymyositis 10.83 9.89 17 100373 2984 70825070
Arteriosclerosis 10.80 9.89 5 100385 16633 70811421
Pulmonary hypertension 10.77 9.89 32 100358 46504 70781550
Superinfection bacterial 10.77 9.89 11 100379 1253 70826801
Cardiomyopathy acute 10.76 9.89 6 100384 271 70827783
Gastric varices 10.76 9.89 8 100382 595 70827459
Haemorrhagic occlusive retinal vasculitis 10.74 9.89 3 100387 19 70828035
Meningitis enteroviral 10.73 9.89 4 100386 69 70827985
Herpes simplex meningoencephalitis 10.73 9.89 4 100386 69 70827985
Incorrect route of product administration 10.73 9.89 13 100377 26479 70801575
Pseudomonal sepsis 10.70 9.89 24 100366 5513 70822541
Central nervous system necrosis 10.62 9.89 6 100384 278 70827776
Fluid imbalance 10.60 9.89 7 100383 430 70827624
Pulmonary congestion 10.56 9.89 12 100378 25142 70802912
Dermo-hypodermitis 10.55 9.89 8 100382 613 70827441
Vitamin D decreased 10.54 9.89 31 100359 8396 70819658
Disability 10.54 9.89 4 100386 14979 70813075
Pyelitis 10.45 9.89 6 100384 287 70827767
Type 2 diabetes mellitus 10.43 9.89 30 100360 44050 70784004
Pneumonia klebsiella 10.41 9.89 21 100369 4483 70823571
Tuberculosis 10.38 9.89 4 100386 14844 70813210
Neurocryptococcosis 10.36 9.89 3 100387 22 70828032
Cholecystitis chronic 10.33 9.89 33 100357 9343 70818711
Anuria 10.31 9.89 55 100335 19598 70808456
Dry mouth 10.30 9.89 58 100332 70399 70757655
Gingival ulceration 10.24 9.89 9 100381 849 70827205
Incoherent 10.23 9.89 28 100362 7278 70820776
Tongue disorder 10.23 9.89 3 100387 13224 70814830
Disseminated varicella zoster virus infection 10.21 9.89 7 100383 458 70827596
Peripheral sensory neuropathy 10.21 9.89 39 100351 12071 70815983
Pericarditis 10.19 9.89 74 100316 84631 70743423
Autoimmune haemolytic anaemia 10.17 9.89 29 100361 7717 70820337
Injection site erythema 10.14 9.89 61 100329 72863 70755191
T-cell prolymphocytic leukaemia 10.14 9.89 4 100386 81 70827973
Adverse event 10.07 9.89 36 100354 49425 70778629
Photosensitivity reaction 10.07 9.89 54 100336 19286 70808768
Drug level increased 10.04 9.89 87 100303 36382 70791672
Electrocardiogram QT prolonged 10.03 9.89 73 100317 83444 70744610
Adenocarcinoma of colon 10.01 9.89 23 100367 5369 70822685
Bladder cancer 9.99 9.89 6 100384 17236 70810818
Pulmonary fibrosis 9.96 9.89 21 100369 34289 70793765

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J05AB11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
FDA MoA N0000020060 DNA Polymerase Inhibitors
FDA EXT N0000175459 Nucleoside Analog
FDA EPC N0000175468 Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
FDA EPC N0000180187 Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor
FDA EPC N0000180188 Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Herpes labialis indication 1475003
Herpes zoster indication 4740000 DOID:8536
Genital herpes simplex indication 33839006 DOID:8704
Varicella indication 38907003 DOID:8659
Recurrent genital herpes simplex indication 402894005
Suppression of Recurrent Herpes Simplex Infection in HIV indication
Suppression of Recurrent Herpes Simplex Infection indication
Prevention of Cytomegalovirus Disease off-label use
Prevention of Herpes Zoster in Immunocompromised Patient off-label use
Dehydration contraindication 34095006
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Hemolytic uremic syndrome contraindication 111407006 DOID:12554
Impaired renal function disorder contraindication 197663003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.97 acidic
pKa2 7.83 Basic
pKa3 3.83 Basic
pKa4 2.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA polymerase catalytic subunit Enzyme INHIBITOR WOMBAT-PK CHEMBL

External reference:

IDSource
4024006 VUID
N0000022011 NUI
D08664 KEGG_DRUG
124832-26-4 SECONDARY_CAS_RN
4020944 VANDF
4024006 VANDF
C0249458 UMLSCUI
CHEBI:9919 CHEBI
TXC PDB_CHEM_ID
CHEMBL1349 ChEMBL_ID
CHEMBL1201110 ChEMBL_ID
DB00577 DRUGBANK_ID
4824 IUPHAR_LIGAND_ID
MZ1IW7Q79D UNII
135398742 PUBCHEM_CID
236081 RXNORM
169290 MMSL
5660 MMSL
d03838 MMSL
005049 NDDF
005050 NDDF
324820003 SNOMEDCT_US
412325002 SNOMEDCT_US
96098007 SNOMEDCT_US
D000077483 MESH_DESCRIPTOR_UI
7106 INN_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0565 TABLET, FILM COATED 1 g ORAL NDA 25 sections
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0565 TABLET, FILM COATED 1 g ORAL NDA 25 sections
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0565 TABLET, FILM COATED 1 g ORAL NDA 25 sections
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0933 TABLET, FILM COATED 500 mg ORAL NDA 25 sections
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0933 TABLET, FILM COATED 500 mg ORAL NDA 25 sections
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0933 TABLET, FILM COATED 500 mg ORAL NDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-4275 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-4276 TABLET, FILM COATED 1 g ORAL ANDA 27 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-5208 TABLET 500 mg ORAL ANDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0781-5209 TABLET 1 g ORAL ANDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6565 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6565 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
valacyclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-937 TABLET, FILM COATED 1 g ORAL ANDA 23 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 16714-697 TABLET, FILM COATED 1 g ORAL ANDA 25 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 16714-697 TABLET, FILM COATED 1 g ORAL ANDA 25 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 16714-698 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 16714-698 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-832 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-965 TABLET, FILM COATED 1 g ORAL ANDA 27 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 31722-704 TABLET, FILM COATED 500 mg ORAL ANDA 24 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 31722-705 TABLET, FILM COATED 1 g ORAL ANDA 24 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-730 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-730 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 43063-771 TABLET, FILM COATED 1 g ORAL ANDA 24 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 43063-771 TABLET, FILM COATED 1 g ORAL ANDA 24 sections
Valacyclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-778 TABLET 500 mg ORAL ANDA 27 sections
Valacyclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-778 TABLET 500 mg ORAL ANDA 27 sections
Valacyclovir Human Prescription Drug Label 1 43353-883 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 49483-690 TABLET 500 mg ORAL ANDA 26 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 49483-691 TABLET 1 g ORAL ANDA 26 sections