phenibut 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4863 1078-21-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • phenibut hydrochloride
  • phenigamma
  • phenibut
  • fenibut
  • bifren
  • phenibut HCl
  • fenibut citrate
  • phenibut citrate
  • phenyl-GABA
phenyl deriv of GABA; RN given refers to cpd without isomeric designation; structure
  • Molecular weight: 179.22
  • Formula: C10H13NO2
  • CLOGP: -1.33
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 63.32
  • ALOGS: -2.06
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.719 Moderate 0.72
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.482 Moderate 0.72
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.250 10^-6 cm/s Moderate 0.72
dh-clint Dog hepatocyte intrinsic clearance 1.242 uL/min/10^6 cells Moderate 0.72
dppb Dog plasma protein binding (% unbound) 84.720 % Moderate 0.72
fcs-ppb Fetal calf serum protein binding (% unbound) 65.690 % Moderate 0.72
herg hERG pIC50 5.400 pIC50 Moderate 0.72
hh-clint Human hepatocyte intrinsic clearance 1.963 uL/min/10^6 cells Moderate 0.72
hlm-clint Human liver microsomal intrinsic clearance 4.036 uL/min/mg protein Moderate 0.72
hppb Human plasma protein binding (% unbound) 87.010 % Moderate 0.72
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 35
kinase-selectivity-class AKT2,AKT3,AXL,BRAF,EIF2AK3,EPHB4,GRK2,PAK4,PDK4,PRKG1,STK33,TEK 12
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.733 Moderate 0.72
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.563 Moderate 0.72
mh-clint Mouse hepatocyte intrinsic clearance 3.811 Moderate 0.72
mppb Mouse plasma protein binding (% unbound) 88.400 Moderate 0.72
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.839 Moderate 0.72
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 87.770 % Moderate 0.72
rat-kpuu-brain Rat brain Kpuu 0.024 % Moderate 0.72
rh-clint Rat hepatocyte intrinsic clearance 1.754 uL/min/10^6 cells Moderate 0.72
rh-fuinc Rat hepatocyte fraction unbound in incubation 87.040 % Moderate 0.72
rppb Rat plasma protein binding (% unbound) 89.720 % Moderate 0.72
solubility-dd Solubility at pH 7.4 in DMSO 887.156 uM Moderate 0.72

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BX22 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Other psychostimulants and nootropics
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D003292 Convulsants
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018682 GABA Agents
MeSH PA D018755 GABA Agonists

Related Drugs by ATC class:

N06BX Other psychostimulants and nootropics 19 drugs
acetylcarnitineadrafinilaniracetamcinnarizineciticolinedeanolfipexideidebenonelinopirdinemeclofenoxatenizofenoneoxiracetam show all 19 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.95 acidic
pKa2 9.54 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA-B receptor GPCR AGONIST SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D10509 KEGG_DRUG
CHEBI:136039 CHEBI
CHEMBL315818 ChEMBL_ID
DB13455 DRUGBANK_ID
C0048007 UMLSCUI
11885 INN_ID
14113 PUBCHEM_CID
T2M58D6LA8 UNII
C008842 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None