linopirdine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4588 105431-72-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • linopirdine
acetylcholine releasing drug
  • Molecular weight: 391.47
  • Formula: C26H21N3O
  • CLOGP: 2.97
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 46.09
  • ALOGS: -5.32
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BX09 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Other psychostimulants and nootropics
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018696 Neuroprotective Agents
MeSH PA D026902 Potassium Channel Blockers
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.92 Basic
pKa2 5.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium voltage-gated channel subfamily KQT member 5 Ion channel BLOCKER Kd 4.80 IUPHAR
Potassium voltage-gated channel subfamily KQT member 4 Ion channel BLOCKER IC50 4.90 IUPHAR
Potassium voltage-gated channel subfamily KQT member 2 Ion channel BLOCKER IC50 5.30 IUPHAR
Potassium voltage-gated channel subfamily KQT member 3 Unclassified INHIBITOR IC50 5.40 IUPHAR
Potassium voltage-gated channel subfamily KQT member 1 Unclassified INHIBITOR IC50 4.40 IUPHAR

External reference:

IDSource
D04741 KEGG_DRUG
CHEMBL319111 ChEMBL_ID
I5TB3NZ94T UNII
6952 INN_ID
CHEBI:34823 CHEBI
DB13806 DRUGBANK_ID
3932 PUBCHEM_CID
2599 IUPHAR_LIGAND_ID
C061017 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None