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linopirdine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| serotonin receptor antagonists | 4588 | 105431-72-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
acetylcholine releasing drug
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK1,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK1,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,ROCK1,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 60 | |||
| kinase-selectivity-class | AXL,BRAF,CDK9,ERBB2,GRK2,MAP2K6 | 6 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06BX09 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Other psychostimulants and nootropics |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D018696 | Neuroprotective Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D026902 | Potassium Channel Blockers |
| MeSH PA | D049990 | Membrane Transport Modulators |
Related Drugs by ATC class:
N06BX Other psychostimulants and nootropics 19 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.92 | Basic |
| pKa2 | 5.31 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Potassium voltage-gated channel subfamily KQT member 2 | Ion channel | BLOCKER | IC50 | 5.30 | IUPHAR | ||||
| Potassium voltage-gated channel subfamily KQT member 5 | Ion channel | BLOCKER | Kd | 4.80 | IUPHAR | ||||
| Potassium voltage-gated channel subfamily KQT member 4 | Ion channel | BLOCKER | IC50 | 4.90 | IUPHAR | ||||
| Potassium voltage-gated channel subfamily KQT member 3 | Ion channel | INHIBITOR | IC50 | 5.40 | IUPHAR | ||||
| Potassium voltage-gated channel subfamily KQT member 1 | Ion channel | INHIBITOR | IC50 | 4.40 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D04741 | KEGG_DRUG |
| CHEBI:34823 | CHEBI |
| FCC | PDB_CHEM_ID |
| CHEMBL319111 | ChEMBL_ID |
| C061017 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2599 | IUPHAR_LIGAND_ID |
| 6952 | INN_ID |
| DB13806 | DRUGBANK_ID |
| I5TB3NZ94T | UNII |
| C0286263 | UMLSCUI |
| 3932 | PUBCHEM_CID |
| I5TB3NZ94T | INXIGHT DRUGS |
Pharmaceutical products:
None