nizofenone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
nicotinic acid or nicotinoyl alcohol derivatives 1956 54533-85-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Y-9179
  • nizofenone fumarate
  • ekonal
  • midafenone
  • nizofenone
Nizofenone is a neuroprotective drug which protects neurons from death following cerebral anoxia (interruption of oxygen supply to the brain). It might thus be useful in the treatment of acute neurological conditions such as stroke.
  • Molecular weight: 412.87
  • Formula: C21H21ClN4O3
  • CLOGP: 4.40
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 0
  • TPSA: 83.95
  • ALOGS: -4.75
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKDC,SIK2,SIK3,STK33,TEK,TTK,ZAP70 42
kinase-selectivity-class AXL,EIF2AK3,GRK2 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BX10 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Other psychostimulants and nootropics
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018696 Neuroprotective Agents
MeSH PA D020011 Protective Agents

Related Drugs by ATC class:

N06BX Other psychostimulants and nootropics 19 drugs
acetylcarnitineadrafinilaniracetamcinnarizineciticolinedeanolfipexideidebenonelinopirdinemeclofenoxateoxiracetamphenibut show all 19 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.82 Basic
pKa2 4.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01465 KEGG_DRUG
54533-86-7 SECONDARY_CAS_RN
C0068887 UMLSCUI
CHEBI:135668 CHEBI
CHEMBL2106822 ChEMBL_ID
DB13546 DRUGBANK_ID
C016910 MESH_SUPPLEMENTAL_RECORD_UI
4514 PUBCHEM_CID
4940 INN_ID
7A2NOC3R88 UNII

Pharmaceutical products:

None