fipexide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1172 34161-24-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • fipexide
  • p-Chlorophenoxyacetylpiperonylpiperazide
  • fipexide hydrochloride
  • fipexide HCl
regulates dopaminergic systems at macromolecular level
  • Molecular weight: 388.85
  • Formula: C20H21ClN2O4
  • CLOGP: 4.47
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 51.24
  • ALOGS: -3.37
  • ROTB: 5

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 3.248 Moderate 0.67
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.475 Moderate 0.67
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 46.452 10^-6 cm/s Moderate 0.67
dh-clint Dog hepatocyte intrinsic clearance 9.183 uL/min/10^6 cells Moderate 0.67
dppb Dog plasma protein binding (% unbound) 2.120 % Moderate 0.67
fcs-ppb Fetal calf serum protein binding (% unbound) 5.670 % Moderate 0.67
herg hERG pIC50 5.659 pIC50 Moderate 0.67
hh-clint Human hepatocyte intrinsic clearance 8.375 uL/min/10^6 cells Moderate 0.67
hlm-clint Human liver microsomal intrinsic clearance 33.574 uL/min/mg protein Moderate 0.67
hppb Human plasma protein binding (% unbound) 1.570 % Moderate 0.67
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K7,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK 35
kinase-selectivity-class AXL,BRAF 2
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.316 Moderate 0.67
mh-clint Mouse hepatocyte intrinsic clearance 39.994 Moderate 0.67
mppb Mouse plasma protein binding (% unbound) 3.420 Moderate 0.67
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.459 Moderate 0.67
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 5.280 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 55.208 uL/min/10^6 cells Moderate 0.67
rh-fuinc Rat hepatocyte fraction unbound in incubation 32.470 % Moderate 0.67
rppb Rat plasma protein binding (% unbound) 2.330 % Moderate 0.67
solubility-dd Solubility at pH 7.4 in DMSO 65.766 uM Moderate 0.67

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BX05 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Other psychostimulants and nootropics

Related Drugs by ATC class:

N06BX Other psychostimulants and nootropics 19 drugs
acetylcarnitineadrafinilaniracetamcinnarizineciticolinedeanolidebenonelinopirdinemeclofenoxatenizofenoneoxiracetamphenibut show all 19 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07345 KEGG_DRUG
C0060394 UMLSCUI
CHEBI:94598 CHEBI
CHEMBL254857 ChEMBL_ID
DB13790 DRUGBANK_ID
C038628 MESH_SUPPLEMENTAL_RECORD_UI
3351 PUBCHEM_CID
2576 INN_ID
34161-23-4 SECONDARY_CAS_RN
TG44VME01D UNII
CHEMBL1377408 ChEMBL_ID

Pharmaceutical products:

None