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acetylcarnitine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 64 | 3040-38-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An acetic acid ester of CARNITINE that facilitates movement of ACETYL COA into the matrices of mammalian MITOCHONDRIA during the oxidation of FATTY ACIDS.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 10 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| S (Water solubility) | 32 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 63 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CAMK2D,CDK4,GRK2,MAPK7,TEK | 8 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06BX12 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Other psychostimulants and nootropics |
| FDA CS | M0003493 | Carnitine |
| MeSH PA | D014803 | Vitamin B Complex |
| MeSH PA | D014815 | Vitamins |
| MeSH PA | D018697 | Nootropic Agents |
| MeSH PA | D018977 | Micronutrients |
| FDA EPC | N0000175903 | Carnitine Analog |
| CHEBI has role | CHEBI:77746 | human metabolite |
Related Drugs by ATC class:
N06BX Other psychostimulants and nootropics 19 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Senile dementia | indication | 15662003 | |
| Alzheimer's disease | indication | 26929004 | DOID:10652 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Seizure disorder | contraindication | 128613002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.41 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4029065 | VUID |
| N0000179824 | NUI |
| 193 | RXNORM |
| C0001040 | UMLSCUI |
| CHEBI:73024 | CHEBI |
| CHEMBL1697733 | ChEMBL_ID |
| DB08842 | DRUGBANK_ID |
| D000108 | MESH_DESCRIPTOR_UI |
| 7045767 | PUBCHEM_CID |
| 6DH1W9VH8Q | UNII |
| DB00583 | DRUGBANK_ID |
| 10540 | MMSL |
| 147388 | MMSL |
| 44191 | MMSL |
| 4970 | MMSL |
| d00491 | MMSL |
| C0087163 | UMLSCUI |
| 10917 | PUBCHEM_CID |
| 6098 | INN_ID |
| 4018934 | VANDF |
| 4020870 | VANDF |
| 4029065 | VANDF |
| D002331 | MESH_DESCRIPTOR_UI |
| 003576 | NDDF |
| 006988 | NDDF |
| 329486002 | SNOMEDCT_US |
| 372601001 | SNOMEDCT_US |
| CHEBI:16347 | CHEBI |
| 6DH1W9VH8Q | INXIGHT DRUGS |
Pharmaceutical products:
None