DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
idebenone 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
1416
58186-27-9
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
hydroxydecyl ubiquinone
CV-2619
CV 2619
idebenone
daruma
raxone
Molecular weight: 338.44
Formula: C19H30O5
CLOGP: 3.42
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 72.83
ALOGS: -4.32
ROTB: 12
Drug dosage:
Dose
Unit
Route
0.90
g
O
ADMET properties:
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Property
Value
Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)
2
Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)
0.50 %
Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)
0.01 mg/mL
Bocci G, Oprea TI, Benet LZ
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Approvals:
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Date
Agency
Company
Orphan
Sept. 8, 2015
EMA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Cholestasis
37.28
31.77
6
3
26942
34929980
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FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
N06BX13
NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Other psychostimulants and nootropics
CHEBI has role
CHEBI:22586
antioxidants
CHEBI has role
CHEBI:173084
ferroptosis inhibitors
MeSH PA
D000975
Antioxidants
MeSH PA
D020011
Protective Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Leber's optic atrophy
indication
58610003
DOID:705
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Cytochrome P450 3A4
Enzyme
P08684
CP3A4_HUMAN
IC50
5.16
DRUG MATRIX
Cytochrome P450 2D6
Enzyme
P10635
CP2D6_HUMAN
IC50
5.52
DRUG MATRIX
Cytochrome P450 2C9
Enzyme
P11712
CP2C9_HUMAN
IC50
5.30
DRUG MATRIX
Cytochrome P450 2C19
Enzyme
P33261
CP2CJ_HUMAN
IC50
6.10
DRUG MATRIX
NAD-dependent protein deacetylase
Unclassified
T1VXA1_SCHMA
IC50
5.72
CHEMBL
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External reference:
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ID
Source
006795
NDDF
3686
PUBCHEM_CID
428158006
SNOMEDCT_US
429666007
SNOMEDCT_US
51296
RXNORM
5465
INN_ID
C0123163
UMLSCUI
C036619
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31687
CHEBI
CHEMBL252556
ChEMBL_ID
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Pharmaceutical products:
None
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Structure 🔎
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L1000
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idebenone