sodium citrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4477	68-04-2

Description:

Molecule	Description
Synonyms: sodium citrate trisodium citrate	Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES. Molecular weight: 258.07 Formula: C6H5Na3O7 CLOGP: LIPINSKI: None HAC: None HDO: None TPSA: 140.62 ALOGS: ROTB: None

Molecule

Description

Synonyms:

sodium citrate
trisodium citrate

Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES.

Molecular weight: 258.07
Formula: C6H5Na3O7
CLOGP:
LIPINSKI: None
HAC: None
HDO: None
TPSA: 140.62
ALOGS:
ROTB: None

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 3, 1980	FDA	B BRAUN

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paraesthesia	12943.57	199.11	3835	17864	153131	63314192
Feeling hot	7743.08	199.11	2025	19674	48329	63418994
Pallor	7659.76	199.11	1820	19879	28748	63438575
Hyperhidrosis	4203.46	199.11	1515	20184	106321	63361002
Thirst	4024.82	199.11	936	20763	13105	63454218
Dizziness	3542.92	199.11	2034	19665	427891	63039432
Nausea	2360.12	199.11	2074	19625	852397	62614926
Dysgeusia	2030.73	199.11	715	20984	45995	63421328
Vision blurred	2006.95	199.11	852	20847	91072	63376251
Asthenia	1133.20	199.11	977	20722	382627	63084696

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paraesthesia	5094.07	177.73	1496	9330	62676	34883429
Feeling hot	2468.56	177.73	660	10166	18712	34927393
Pallor	2258.07	177.73	653	10173	24827	34921278
Thirst	1480.80	177.73	367	10459	7528	34938577
Hyperhidrosis	1411.00	177.73	608	10218	75084	34871021
Dizziness	1000.58	177.73	691	10135	217830	34728275
Nausea	927.80	177.73	789	10037	339119	34606986
Dysgeusia	876.14	177.73	323	10503	26174	34919931
Vision blurred	568.68	177.73	279	10547	45684	34900421
Appendicolith	378.83	177.73	130	10696	8471	34937634

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Paraesthesia	18162.07	137.21	5331	27105	170992	79540960
Feeling hot	10084.80	137.21	2685	29751	57049	79654903
Pallor	9506.82	137.21	2472	29964	47590	79664362
Hyperhidrosis	5516.67	137.21	2122	30314	149370	79562582
Thirst	5433.19	137.21	1302	31134	17317	79694635
Dizziness	4518.40	137.21	2724	29712	523717	79188235
Nausea	3336.55	137.21	2863	29573	954333	78757619
Dysgeusia	2940.28	137.21	1037	31399	56140	79655812
Vision blurred	2619.99	137.21	1129	31307	104769	79607183
Asthenia	1321.47	137.21	1307	31129	510382	79201570

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	B05CB02	BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Salt solutions
CHEBI has role	CHEBI:50249	anticoagulants
CHEBI has role	CHEBI:35617	flavouring agents
MeSH PA	D000925	Anticoagulants
MeSH PA	D002021	Buffers
MeSH PA	D005503	Food Additives
MeSH PA	D005520	Food Preservatives
MeSH PA	D006401	Hematologic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Peptic ulcer	indication	13200003	DOID:750
Heartburn	indication	16331000
Cough	indication	49727002
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Rhinitis	indication	70076002	DOID:4483
Common cold	indication	82272006	DOID:10459
Indigestion	indication	162031009
Gastroesophageal reflux disease	indication	235595009	DOID:8534
Gastric Hypersecretory Conditions	indication

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

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Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN		Ki	7		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	4.41		CHEMBL

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External reference:

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ID	Source
000732	NDDF
000758	NDDF
002077	NDDF
002078	NDDF
002332	NDDF
253204	RXNORM
4017463	VUID
4017463	VANDF
412546005	SNOMEDCT_US
412547001	SNOMEDCT_US

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Pharmaceutical products:

None