bitolterol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| bronchodilators, phenethylamine derivatives | 384 | 30392-40-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a short-acting beta2 adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 28, 1984 | FDA | SANOFI AVENTIS US |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R03AC17 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES ADRENERGICS, INHALANTS Selective beta-2-adrenoreceptor agonists |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D000322 | Adrenergic Agonists |
| MeSH PA | D058666 | Adrenergic beta-2 Receptor Agonists |
| MeSH PA | D000318 | Adrenergic beta-Agonists |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
| CHEBI has role | CHEBI:35522 | beta-adrenergic agonists |
| CHEBI has role | CHEBI:35523 | bronchodilator |
| CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
| CHEBI has role | CHEBI:50266 | Prodrugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Bronchiectasis | indication | 12295008 | DOID:9563 |
| Bronchitis | indication | 32398004 | DOID:6132 |
| Pulmonary emphysema | indication | 87433001 | |
| Asthma | indication | 195967001 | DOID:2841 |
| Asthma management | indication | 406162001 | |
| Acute exacerbation of asthma | indication | 708038006 | |
| Bronchospasm Prevention | indication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 14.0 | acidic |
| pKa2 | 9.19 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-2 adrenergic receptor | GPCR | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019101 | VUID |
| N0000147359 | NUI |
| D00684 | KEGG_DRUG |
| 30392-41-7 | SECONDARY_CAS_RN |
| 19499 | RXNORM |
| C0053817 | UMLSCUI |
| CHEBI:3133 | CHEBI |
| CHEMBL1201295 | ChEMBL_ID |
| CHEMBL1200405 | ChEMBL_ID |
| DB00901 | DRUGBANK_ID |
| C011685 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3855 | INN_ID |
| 9KY0QXD6LI | UNII |
| 35330 | PUBCHEM_CID |
| 1209 | MMSL |
| 4292 | MMSL |
| d00754 | MMSL |
| 387233000 | SNOMEDCT_US |
| 412217002 | SNOMEDCT_US |
| 41985001 | SNOMEDCT_US |
| 4019101 | VANDF |
| 4019636 | VANDF |
| 001816 | NDDF |
| 004733 | NDDF |
Pharmaceutical products:
None