Stem definition | Drug id | CAS RN |
---|---|---|
sympathomimetic, phenethyl derivatives | 2146 | 59-42-7 |
Dose | Unit | Route |
---|---|---|
4 | mg | P |
4 | mg | N |
40 | mg | O |
Property | Value | Reference |
---|---|---|
MRTD (Maximum Recommended Therapeutic Daily Dose) | 4.98 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 35 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 1226.96 | 10.75 | 5843 | 721399 | 241407 | 62520373 |
Completed suicide | 1147.69 | 10.75 | 3975 | 723267 | 141698 | 62620082 |
Exposure to toxic agent | 686.52 | 10.75 | 545 | 726697 | 5042 | 62756738 |
Infusion related reaction | 613.21 | 10.75 | 4859 | 722383 | 240662 | 62521118 |
Sinusitis | 507.55 | 10.75 | 4377 | 722865 | 222276 | 62539504 |
Acute hepatic failure | 460.51 | 10.75 | 785 | 726457 | 17542 | 62744238 |
Blood pressure fluctuation | 415.05 | 10.75 | 1321 | 725921 | 44996 | 62716784 |
Muscle injury | 283.99 | 10.75 | 1489 | 725753 | 63856 | 62697924 |
Irritable bowel syndrome | 276.49 | 10.75 | 1753 | 725489 | 80659 | 62681121 |
Folliculitis | 275.74 | 10.75 | 1558 | 725684 | 68759 | 62693021 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 680.62 | 10.95 | 3439 | 294597 | 196923 | 34461972 |
Infusion related reaction | 644.62 | 10.95 | 1408 | 296628 | 51649 | 34607246 |
Completed suicide | 571.03 | 10.95 | 1988 | 296048 | 96180 | 34562715 |
Exposure to toxic agent | 402.43 | 10.95 | 297 | 297739 | 3378 | 34655517 |
Blood pressure fluctuation | 366.21 | 10.95 | 721 | 297315 | 24528 | 34634367 |
Heart rate decreased | 242.83 | 10.95 | 707 | 297329 | 31038 | 34627857 |
Overdose | 241.80 | 10.95 | 1464 | 296572 | 89595 | 34569300 |
Blood pressure increased | 217.33 | 10.95 | 1390 | 296646 | 86712 | 34572183 |
Acute hepatic failure | 215.14 | 10.95 | 411 | 297625 | 13663 | 34645232 |
Drug interaction | 176.96 | 10.95 | 1164 | 296872 | 224782 | 34434113 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1846.48 | 10.46 | 6211 | 827952 | 239556 | 78670669 |
Toxicity to various agents | 1776.30 | 10.46 | 8906 | 825257 | 412634 | 78497591 |
Exposure to toxic agent | 1071.23 | 10.46 | 836 | 833327 | 8322 | 78901903 |
Infusion related reaction | 1051.66 | 10.46 | 4982 | 829181 | 225255 | 78684970 |
Blood pressure fluctuation | 775.41 | 10.46 | 1980 | 832183 | 65165 | 78845060 |
Acute hepatic failure | 628.87 | 10.46 | 1130 | 833033 | 28983 | 78881242 |
Drug interaction | 512.37 | 10.46 | 2416 | 831747 | 412767 | 78497458 |
Intentional overdose | 485.32 | 10.46 | 2296 | 831867 | 103664 | 78806561 |
Intentional product misuse | 473.57 | 10.46 | 2113 | 832050 | 93052 | 78817173 |
Overdose | 426.97 | 10.46 | 3343 | 830820 | 180863 | 78729362 |
None
Source | Code | Description |
---|---|---|
ATC | C01CA06 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents |
ATC | R01AA04 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, plain |
ATC | R01AB01 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Sympathomimetics, combinations excl. corticosteroids |
ATC | R01BA03 | RESPIRATORY SYSTEM NASAL PREPARATIONS NASAL DECONGESTANTS FOR SYSTEMIC USE Sympathomimetics |
ATC | R01BA53 | RESPIRATORY SYSTEM NASAL PREPARATIONS NASAL DECONGESTANTS FOR SYSTEMIC USE Sympathomimetics |
ATC | S01FB01 | SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Sympathomimetics excl. antiglaucoma preparations |
ATC | S01FB51 | SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Sympathomimetics excl. antiglaucoma preparations |
ATC | S01GA05 | SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants |
ATC | S01GA55 | SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Sympathomimetics used as decongestants |
CHEBI has role | CHEBI:35524 | sympathomimetic |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Proctitis | indication | 3951002 | DOID:3127 |
Sinus headache | indication | 4969004 | |
Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
Dilated pupil | indication | 37125009 | |
Cough | indication | 49727002 | |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Rhinitis | indication | 70076002 | DOID:4483 |
Hemorrhoids | indication | 70153002 | DOID:9746 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.15 | acidic |
pKa2 | 13.64 | acidic |
pKa3 | 8.71 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
10% | PHENYLEPHRINE HYDROCHLORIDE | PARAGON BIOTECK | N203510 | March 21, 2013 | RX | SOLUTION/DROPS | OPHTHALMIC | 8859623 | Nov. 14, 2033 | DILATION OF THE PUPIL |
2.5% | PHENYLEPHRINE HYDROCHLORIDE | PARAGON BIOTECK | N203510 | March 21, 2013 | RX | SOLUTION/DROPS | OPHTHALMIC | 8859623 | Nov. 14, 2033 | DILATION OF THE PUPIL |
EQ 0.3% BASE;EQ 1% BASE | OMIDRIA | RAYNER SURGICAL | N205388 | May 30, 2014 | RX | SOLUTION | IRRIGATION | 8173707 | July 30, 2023 | MAINTAINING PUPIL SIZE BY PREVENTING INTRAOPERATIVE MIOSIS AND REDUCING POSTOPERATIVE OCULAR PAIN |
EQ 0.3% BASE;EQ 1% BASE | OMIDRIA | RAYNER SURGICAL | N205388 | May 30, 2014 | RX | SOLUTION | IRRIGATION | 9278101 | July 30, 2023 | MAINTAINING PUPIL SIZE BY PREVENTING INTRAOPERATIVE MIOSIS AND REDUCING POSTOPERATIVE OCULAR PAIN |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10% | PHENYLEPHRINE HYDROCHLORIDE | MANKIND PHARMA | A216496 | Jan. 11, 2023 | RX | SOLUTION/DROPS | OPHTHALMIC | July 17, 2023 | COMPETITIVE GENERIC THERAPY |
2.5% | PHENYLEPHRINE HYDROCHLORIDE | MANKIND PHARMA | A216859 | Sept. 29, 2022 | RX | SOLUTION/DROPS | OPHTHALMIC | April 5, 2023 | COMPETITIVE GENERIC THERAPY |
2.5%;1% | MYDCOMBI | EYENOVIA | N215352 | May 5, 2023 | RX | SPRAY, METERED | OPHTHALMIC | May 5, 2026 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Alpha-1A adrenergic receptor | GPCR | AGONIST | Ki | 5.30 | WOMBAT-PK | CHEMBL | |||
Alpha-1D adrenergic receptor | GPCR | AGONIST | IC50 | 5.90 | WOMBAT-PK | CHEMBL | |||
Alpha-1B adrenergic receptor | GPCR | AGONIST | Ki | 6.90 | WOMBAT-PK | CHEMBL | |||
Adrenergic receptor alpha-2 | GPCR | Ki | 6.41 | CHEMBL | |||||
Beta-1 adrenergic receptor | GPCR | Ki | 4.89 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 6.03 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 5.90 | CHEMBL | |||||
Adrenergic receptor alpha-2 | GPCR | Ki | 6.57 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | Ki | 5.21 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | EC50 | 8 | CHEMBL |
ID | Source |
---|---|
001825 | NDDF |
001826 | NDDF |
001827 | NDDF |
001828 | NDDF |
1307 | MMSL |
1416-03-1 | SECONDARY_CAS_RN |
17162-39-9 | SECONDARY_CAS_RN |
1WS297W6MV | UNII |
221139 | RXNORM |
30342 | MMSL |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
4 WayFast Acting | HUMAN OTC DRUG LABEL | 1 | 0067-2086 | SPRAY | 10 mg | NASAL | OTC monograph final | 14 sections |
CHILDRENS DIMETAPP COLD AND ALLERGY | HUMAN OTC DRUG LABEL | 2 | 0031-2235 | LIQUID | 2.50 mg | ORAL | OTC monograph final | 16 sections |
CHILDRENS DIMETAPP COLD AND COUGH | HUMAN OTC DRUG LABEL | 3 | 0031-2234 | LIQUID | 2.50 mg | ORAL | OTC monograph final | 16 sections |
Childrens Dimetapp Multi-Symptom Cold and Flu | HUMAN OTC DRUG LABEL | 3 | 0031-2249 | LIQUID | 5 mg | ORAL | Unapproved drug other | 17 sections |
Childrens Robitussin Cough and Cold CF | HUMAN OTC DRUG LABEL | 3 | 0031-8716 | LIQUID | 2.50 mg | ORAL | OTC monograph final | 17 sections |
Childrens Robitussin Cough and Cold CF | HUMAN OTC DRUG LABEL | 3 | 0031-8716 | LIQUID | 2.50 mg | ORAL | OTC monograph final | 17 sections |
Childrens Robitussin Cough and Cold CF | HUMAN OTC DRUG LABEL | 3 | 0031-8716 | LIQUID | 2.50 mg | ORAL | OTC monograph final | 17 sections |
Cyclomydril | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-0359 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 20 sections |
Cyclomydril | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0065-0359 | SOLUTION/ DROPS | 10 mg | OPHTHALMIC | ANDA | 20 sections |
Fresh Clear | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-0000 | SOLUTION/ DROPS | 1.20 mg | OPHTHALMIC | Export only | 1 sections |