thioacetazone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2631 104-06-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thioacetazone
  • ambathizon
  • benthiozone
  • benzothiozane
  • benzothiozon
  • thiacetazone
  • thiocarbazil
  • thiocarbazyl
  • amithiozone
A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217)
  • Molecular weight: 236.29
  • Formula: C10H12N4OS
  • CLOGP: 0.88
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 79.51
  • ALOGS: -3.67
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J04AK07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Other drugs for treatment of tuberculosis
ATC J04AM04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000995 Antitubercular Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pulmonary tuberculosis indication 154283005 DOID:2957




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.38 acidic
pKa2 11.42 acidic
pKa3 13.37 acidic
pKa4 2.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D08584 KEGG_DRUG
C0039834 UMLSCUI
CHEBI:134958 CHEBI
CHEMBL375492 ChEMBL_ID
9568512 PUBCHEM_CID
DB12829 DRUGBANK_ID
D013828 MESH_DESCRIPTOR_UI
252 INN_ID
MMG78X7SSR UNII

Pharmaceutical products:

None