trimethoprim Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, dihydrofolate reductase (DHFR) inhibitors, trimethoprim derivatives 2755 738-70-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trimethoprim
  • trimethoprim sulfate
  • trimethoprim hydrochloride
  • trimethioprim
  • trimetoprim
  • trimopan
  • trimethoprim HCl
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
  • Molecular weight: 290.32
  • Formula: C14H18N4O3
  • CLOGP: 0.98
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 105.51
  • ALOGS: -2.67
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.37 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 70 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 15.75 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 30, 1973 FDA MUTUAL PHARM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 774.95 9.70 1964 131361 241861 46310876
Drug reaction with eosinophilia and systemic symptoms 449.90 9.70 486 132839 29062 46523675
Pyrexia 392.62 9.70 1998 131327 346804 46205933
Pancytopenia 364.63 9.70 772 132553 84286 46468451
Febrile neutropenia 349.40 9.70 809 132516 93818 46458919
Neutropenia 333.68 9.70 1032 132293 142172 46410565
Thrombocytopenia 317.23 9.70 936 132389 125645 46427092
Completed suicide 298.06 9.70 34 133291 145886 46406851
Drug ineffective 268.03 9.70 1016 132309 676822 45875915
Cytomegalovirus infection 239.35 9.70 277 133048 17867 46534870
Rheumatoid arthritis 234.26 9.70 205 133120 240010 46312727
Pneumocystis jirovecii pneumonia 220.20 9.70 244 133081 15004 46537733
Acute kidney injury 214.19 9.70 1276 132049 234579 46318158
Stevens-Johnson syndrome 208.10 9.70 293 133032 23004 46529733
Leukopenia 204.15 9.70 539 132786 67804 46484933
Rash maculo-papular 198.10 9.70 315 133010 27559 46525178
Toxic epidermal necrolysis 184.06 9.70 270 133055 22008 46530729
Hyperkalaemia 180.93 9.70 428 132897 50281 46502456
Agranulocytosis 176.28 9.70 264 133061 21921 46530816
Neutrophil count decreased 170.90 9.70 381 132944 43045 46509692
Bronchopulmonary aspergillosis 151.94 9.70 144 133181 7352 46545385
Fall 147.77 9.70 466 132859 328631 46224106
Nocardiosis 147.13 9.70 78 133247 1539 46551198
Hepatocellular injury 132.22 9.70 273 133052 29249 46523488
Rash 130.58 9.70 1573 131752 354939 46197798
Injection site pain 130.03 9.70 72 133253 107080 46445657
Pain 123.01 9.70 828 132497 476120 46076617
Drug abuse 121.63 9.70 18 133307 63390 46489347
Toxicity to various agents 118.26 9.70 269 133056 211497 46341240
Febrile bone marrow aplasia 117.09 9.70 120 133205 6742 46545995
Platelet count decreased 116.06 9.70 579 132746 99445 46453292
Pain in extremity 105.94 9.70 381 132944 258299 46294438
Alopecia 105.43 9.70 189 133136 162225 46390512
Anaemia 104.89 9.70 1154 132171 254625 46298112
Psoriasis 102.55 9.70 48 133277 78556 46474181
Lymphopenia 102.07 9.70 168 133157 15125 46537612
Septic shock 100.09 9.70 378 132947 57515 46495222
Blood pressure increased 98.89 9.70 130 133195 126536 46426201
Death 98.57 9.70 559 132766 334989 46217748
Bone marrow failure 97.85 9.70 243 133082 29426 46523311
Intentional overdose 97.33 9.70 32 133293 64912 46487825
White blood cell count decreased 97.02 9.70 600 132725 111631 46441106
Injection site erythema 94.73 9.70 47 133278 74380 46478357
Immunosuppressant drug level increased 94.55 9.70 77 133248 3205 46549532
Cytokine release syndrome 94.03 9.70 102 133223 6121 46546616
Toxic skin eruption 89.39 9.70 141 133184 12246 46540491
Encephalitis viral 87.96 9.70 56 133269 1574 46551163
Plasma cell myeloma 84.97 9.70 300 133025 44178 46508559
Sepsis 83.45 9.70 669 132656 135345 46417392
Soft tissue disorder 82.15 9.70 79 133246 4107 46548630
Headache 80.76 9.70 926 132399 477426 46075311
Fatigue 80.72 9.70 1239 132086 607458 45945279
Tumour lysis syndrome 79.95 9.70 101 133224 7135 46545602
Congenital umbilical hernia 79.92 9.70 35 133290 443 46552294
Transplant rejection 78.81 9.70 116 133209 9480 46543257
Eosinophilia 78.28 9.70 171 133154 19046 46533691
Pre-engraftment immune reaction 77.03 9.70 28 133297 208 46552529
Wrong technique in product usage process 76.13 9.70 30 133295 54392 46498345
Product dose omission issue 75.90 9.70 238 133087 168282 46384455
Hyponatraemia 75.52 9.70 522 132803 100810 46451927
Myocardial infarction 75.19 9.70 101 133224 97427 46455310
Infection 72.34 9.70 639 132686 132953 46419784
Interstitial lung disease 71.77 9.70 325 133000 53624 46499113
Suicide attempt 71.17 9.70 34 133291 55002 46497735
Deafness transitory 70.95 9.70 49 133276 1583 46551154
Lymphocyte count decreased 70.51 9.70 196 133129 25393 46527344
Overdose 70.43 9.70 114 133211 101865 46450872
Polyomavirus-associated nephropathy 70.16 9.70 47 133278 1443 46551294
Hypogammaglobulinaemia 68.33 9.70 81 133244 5357 46547380
BK virus infection 68.03 9.70 60 133265 2789 46549948
Feeling abnormal 68.01 9.70 161 133164 124899 46427838
Depression 67.94 9.70 253 133072 169851 46382886
Folliculitis 67.61 9.70 86 133239 6117 46546620
Injection site pruritus 66.19 9.70 16 133309 39727 46513010
Injection site reaction 65.91 9.70 27 133298 47822 46504915
Suicidal ideation 65.37 9.70 40 133285 56342 46496395
Arthralgia 65.32 9.70 696 132629 363907 46188830
Cardiac failure congestive 63.88 9.70 102 133223 91648 46461089
Muscle injury 63.67 9.70 74 133251 4792 46547945
Kidney transplant rejection 63.10 9.70 68 133257 4050 46548687
Cholestasis 61.70 9.70 193 133132 26700 46526037
Thrombotic microangiopathy 60.56 9.70 95 133230 8211 46544526
Hepatic function abnormal 60.51 9.70 226 133099 34195 46518542
Cytomegalovirus viraemia 58.43 9.70 68 133257 4410 46548327
Renal tubular acidosis 58.39 9.70 43 133282 1540 46551197
Human ehrlichiosis 57.45 9.70 22 133303 192 46552545
Epstein-Barr virus infection 57.15 9.70 83 133242 6701 46546036
Intentional product misuse 56.66 9.70 32 133293 47096 46505641
Pneumomediastinum 56.26 9.70 38 133287 1183 46551554
Inappropriate schedule of product administration 55.72 9.70 62 133263 64951 46487786
Immune reconstitution inflammatory syndrome 55.61 9.70 75 133250 5650 46547087
Blood creatinine increased 54.81 9.70 390 132935 76013 46476724
Posterior reversible encephalopathy syndrome 54.18 9.70 128 133197 15013 46537724
Pemphigus 54.06 9.70 31 133294 45243 46507494
Pseudomonas infection 53.12 9.70 98 133227 9660 46543077
Urinary tract infection 52.79 9.70 903 132422 219363 46333374
Device expulsion 52.39 9.70 8 133317 27534 46525203
Injection site swelling 52.01 9.70 25 133300 40302 46512435
Graft versus host disease 51.75 9.70 78 133247 6510 46546227
Human herpesvirus 6 infection 51.62 9.70 48 133277 2391 46550346
Acute febrile neutrophilic dermatosis 51.42 9.70 50 133275 2635 46550102
Cytopenia 51.38 9.70 85 133240 7683 46545054
Gait disturbance 51.10 9.70 227 133098 145036 46407701
Injection site bruising 50.91 9.70 19 133306 35617 46517120
Aspergillus infection 49.12 9.70 78 133247 6812 46545925
Tenosynovitis stenosans 48.45 9.70 42 133283 1907 46550830
Klebsiella infection 48.30 9.70 76 133249 6586 46546151
Multiple organ dysfunction syndrome 48.17 9.70 282 133043 51428 46501309
Birth mark 48.08 9.70 20 133305 221 46552516
Anxiety 47.62 9.70 314 133011 181643 46371094
Synovial fluid analysis 47.60 9.70 36 133289 1343 46551394
Maternal exposure during pregnancy 47.43 9.70 143 133182 102406 46450331
Pneumonia viral 47.24 9.70 75 133250 6549 46546188
Pneumonia aspiration 47.07 9.70 197 133128 31408 46521329
Haemophagocytic lymphohistiocytosis 46.96 9.70 85 133240 8257 46544480
Enterococcal infection 46.95 9.70 77 133248 6910 46545827
Complications of transplanted kidney 46.87 9.70 44 133281 2219 46550518
Dizziness 46.25 9.70 689 132636 339725 46213012
Psoriatic arthropathy 46.24 9.70 23 133302 36356 46516381
Porphyria acute 45.18 9.70 22 133303 360 46552377
Strongyloidiasis 44.90 9.70 29 133296 836 46551901
Product use in unapproved indication 44.87 9.70 424 132901 89849 46462888
Aplastic anaemia 44.29 9.70 76 133249 7077 46545660
Hypophagia 43.12 9.70 182 133143 29124 46523613
Systemic lupus erythematosus 41.22 9.70 77 133248 65103 46487634
Palpitations 41.13 9.70 137 133188 95122 46457615
Brain abscess 40.71 9.70 36 133289 1679 46551058
Glossodynia 40.62 9.70 40 133285 44333 46508404
Breast cancer 40.57 9.70 42 133283 45476 46507261
Hepatitis acute 40.40 9.70 79 133246 8135 46544602
Accidental exposure to product 40.38 9.70 6 133319 21075 46531662
Chronic obstructive pulmonary disease 40.17 9.70 64 133261 57569 46495168
Intentional self-injury 39.71 9.70 10 133315 24156 46528581
Osteoarthritis 39.46 9.70 73 133252 61952 46490785
Conjunctivitis 39.43 9.70 115 133210 15309 46537428
Infective pulmonary exacerbation of cystic fibrosis 39.36 9.70 92 133233 10715 46542022
Renal impairment 39.31 9.70 354 132971 74018 46478719
Myelosuppression 39.00 9.70 75 133250 7628 46545109
Product quality issue 38.99 9.70 27 133298 35621 46517116
Drug intolerance 38.34 9.70 254 133071 146795 46405942
Bacterial sepsis 38.16 9.70 49 133276 3518 46549219
Pulmonary alveolar haemorrhage 38.13 9.70 53 133272 4109 46548628
Aplasia 38.06 9.70 49 133276 3527 46549210
Osteonecrosis of jaw 37.70 9.70 26 133299 34376 46518361
Hypophosphataemia 37.63 9.70 72 133253 7295 46545442
Rhinovirus infection 37.42 9.70 49 133276 3587 46549150
Drug-induced liver injury 36.90 9.70 157 133168 25211 46527526
Toxoplasmosis 36.61 9.70 31 133294 1363 46551374
Cholestatic liver injury 36.48 9.70 37 133288 2053 46550684
Coronary artery disease 36.34 9.70 26 133299 33726 46519011
Scleritis 35.97 9.70 43 133282 2869 46549868
Cushingoid 35.46 9.70 64 133261 6202 46546535
Drug withdrawal syndrome 35.27 9.70 17 133308 27367 46525370
Incorrect dose administered 35.26 9.70 47 133278 45503 46507234
Photophobia 34.86 9.70 106 133219 14438 46538299
Pneumonia bacterial 34.85 9.70 67 133258 6812 46545925
Trimethylaminuria 33.63 9.70 14 133311 155 46552582
Memory impairment 33.54 9.70 111 133214 77226 46475511
Mucosal inflammation 33.39 9.70 208 133117 38768 46513969
Infusion related reaction 33.30 9.70 162 133163 101046 46451691
Systemic candida 33.25 9.70 40 133285 2687 46550050
Pseudohyponatraemia 33.13 9.70 11 133314 60 46552677
Hyperuricaemia 33.08 9.70 53 133272 4664 46548073
Acute respiratory distress syndrome 32.92 9.70 137 133188 21785 46530952
Haemolytic anaemia 32.85 9.70 81 133244 9761 46542976
Abdominal discomfort 32.78 9.70 275 133050 150890 46401847
Stress 32.50 9.70 61 133264 51490 46501247
Mucosal erosion 32.50 9.70 29 133296 1369 46551368
Angina pectoris 32.44 9.70 18 133307 26757 46525980
Stomatitis 32.06 9.70 317 133008 67980 46484757
Cerebral toxoplasmosis 32.04 9.70 22 133303 704 46552033
Knee arthroplasty 31.55 9.70 14 133311 23651 46529086
Sleep disorder due to general medical condition, insomnia type 31.49 9.70 55 133270 5194 46547543
Functional gastrointestinal disorder 31.26 9.70 42 133283 3152 46549585
Drug dependence 31.26 9.70 9 133316 19892 46532845
Enterocolitis 31.16 9.70 60 133265 6108 46546629
Pneumonia influenzal 30.60 9.70 29 133296 1480 46551257
Graft versus host disease in gastrointestinal tract 30.43 9.70 37 133288 2513 46550224
Ureaplasma infection 30.39 9.70 18 133307 443 46552294
Drug eruption 30.25 9.70 131 133194 21198 46531539
Dysbiosis 30.19 9.70 19 133306 523 46552214
Blood glucose increased 30.11 9.70 105 133220 71908 46480829
Bicytopenia 30.03 9.70 30 133295 1634 46551103
Mobility decreased 29.84 9.70 82 133243 60512 46492225
Pseudoporphyria 29.72 9.70 13 133312 164 46552573
Loss of consciousness 29.71 9.70 184 133141 108054 46444683
Hand deformity 29.59 9.70 33 133292 34541 46518196
Upper respiratory tract inflammation 29.28 9.70 38 133287 2757 46549980
Rash erythematous 29.23 9.70 183 133142 34167 46518570
Poisoning 29.20 9.70 3 133322 13991 46538746
Drug interaction 29.19 9.70 773 132552 202321 46350416
Exposure during pregnancy 29.17 9.70 185 133140 108027 46444710
Hypoaesthesia 29.16 9.70 209 133116 118660 46434077
Renal transplant failure 29.15 9.70 20 133305 639 46552098
Purpura 29.15 9.70 78 133247 9880 46542857
Balance disorder 29.09 9.70 91 133234 64430 46488307
Pneumonia 29.07 9.70 1333 131992 374987 46177750
Meningitis aseptic 29.00 9.70 46 133279 4013 46548724
Tenderness 28.97 9.70 110 133215 16771 46535966
Treatment failure 28.92 9.70 152 133173 92935 46459802
Obliterative bronchiolitis 28.41 9.70 30 133295 1745 46550992
Pneumonia fungal 28.16 9.70 46 133279 4114 46548623
Cerebrovascular accident 28.13 9.70 171 133154 100868 46451869
Graft loss 27.87 9.70 16 133309 371 46552366
Acute generalised exanthematous pustulosis 27.86 9.70 74 133251 9331 46543406
Cerebral microhaemorrhage 27.86 9.70 11 133314 105 46552632
Neutropenic sepsis 27.85 9.70 88 133237 12236 46540501
West Nile viral infection 27.56 9.70 16 133309 379 46552358
Lip swelling 27.31 9.70 144 133181 25251 46527486
Cardio-respiratory arrest 27.30 9.70 84 133241 59785 46492952
Mixed liver injury 27.27 9.70 39 133286 3104 46549633
Shock symptom 27.12 9.70 9 133316 49 46552688
Arthropathy 27.04 9.70 137 133188 84563 46468174
Red blood cell sedimentation rate increased 26.86 9.70 16 133309 22873 46529864
Eyelid scar 26.72 9.70 7 133318 13 46552724
Pharyngitis 26.49 9.70 110 133215 17473 46535264
Hypofibrinogenaemia 26.48 9.70 23 133302 1047 46551690
Fixed eruption 26.42 9.70 21 133304 844 46551893
Coagulation test abnormal 26.35 9.70 19 133306 658 46552079
Therapeutic product effect incomplete 26.35 9.70 124 133201 78029 46474708
Delayed graft function 26.22 9.70 22 133303 955 46551782
Blood lactate dehydrogenase increased 26.14 9.70 122 133203 20378 46532359
Pleuritic pain 26.02 9.70 57 133268 6359 46546378
Lower respiratory tract infection 26.00 9.70 256 133069 54833 46497904
Pneumonia streptococcal 25.99 9.70 28 133297 1667 46551070
Pneumonia cytomegaloviral 25.97 9.70 30 133295 1930 46550807
Chest pain 25.96 9.70 351 132974 175973 46376764
Weight increased 25.84 9.70 323 133002 164150 46388587
Hypertriglyceridaemia 25.82 9.70 53 133272 5651 46547086
No adverse event 25.81 9.70 36 133289 34195 46518542
Respiratory failure 25.75 9.70 397 132928 94419 46458318
Infection reactivation 25.74 9.70 20 133305 777 46551960
Herpes simplex oesophagitis 25.64 9.70 11 133314 132 46552605
Clostridium difficile colitis 25.58 9.70 113 133212 18440 46534297
Migraine 25.47 9.70 108 133217 69918 46482819
Clostridium difficile infection 25.41 9.70 140 133185 24963 46527774
Hypoalbuminaemia 25.40 9.70 75 133250 10052 46542685
Bronchiectasis 25.31 9.70 71 133254 9245 46543492
Acute graft versus host disease 25.19 9.70 43 133282 3987 46548750
Product use issue 24.89 9.70 163 133162 94481 46458256
Necrosis ischaemic 24.71 9.70 20 133305 825 46551912
Crepitations 24.57 9.70 54 133271 6038 46546699
Liver function test abnormal 24.42 9.70 221 133104 46266 46506471
Lymph node palpable 24.41 9.70 10 133315 106 46552631
Oral candidiasis 24.34 9.70 107 133218 17425 46535312
Inappropriate antidiuretic hormone secretion 24.29 9.70 92 133233 14010 46538727
Lung transplant rejection 24.20 9.70 19 133306 750 46551987
Lupus enteritis 24.08 9.70 9 133316 73 46552664
Nasopharyngitis 23.97 9.70 303 133022 153695 46399042
Fear of eating 23.95 9.70 14 133311 336 46552401
Pseudomembranous colitis 23.93 9.70 37 133288 3158 46549579
Asthma 23.90 9.70 158 133167 91384 46461353
Adverse event 23.78 9.70 38 133287 34146 46518591
Cytomegalovirus infection reactivation 23.78 9.70 25 133300 1447 46551290
Mucocutaneous rash 23.68 9.70 7 133318 24 46552713
Aplasia pure red cell 23.53 9.70 44 133281 4381 46548356
Brain stem glioma 23.36 9.70 9 133316 80 46552657
Product substitution issue 23.24 9.70 7 133318 15024 46537713
Dermatitis allergic 23.19 9.70 84 133241 12519 46540218
Unevaluable event 23.10 9.70 62 133263 46113 46506624
Mycobacterium abscessus infection 23.08 9.70 17 133308 609 46552128
Sopor 23.07 9.70 14 133311 19814 46532923
Cytomegalovirus test positive 23.03 9.70 34 133291 2786 46549951
Hepatitis 22.83 9.70 164 133161 32051 46520686
Lymphocele 22.76 9.70 19 133306 819 46551918
Acute myocardial infarction 22.67 9.70 35 133290 31889 46520848
Drug resistance 22.61 9.70 104 133221 17264 46535473
Uveal prolapse 22.61 9.70 6 133319 12 46552725
Herpes simplex 22.60 9.70 58 133267 7165 46545572
Hypoaldosteronism 22.59 9.70 11 133314 180 46552557
Bacterial infection 22.54 9.70 99 133226 16117 46536620
Femur fracture 22.26 9.70 45 133280 36952 46515785
Hip arthroplasty 22.20 9.70 12 133313 18100 46534637
Acute myopia 22.00 9.70 9 133316 95 46552642
Blood pressure fluctuation 21.99 9.70 33 133292 30415 46522322
Blood pressure systolic increased 21.98 9.70 30 133295 28757 46523980
C-reactive protein increased 21.95 9.70 260 133065 58330 46494407
Blister 21.85 9.70 209 133116 44422 46508315
Crying 21.84 9.70 17 133308 21124 46531613
Pseudomyopia 21.72 9.70 8 133317 62 46552675
Bacteraemia 21.59 9.70 89 133236 14090 46538647
Injection site mass 21.51 9.70 8 133317 15032 46537705
Pathogen resistance 21.43 9.70 51 133274 6009 46546728
Desmoplastic small round cell tumour 21.32 9.70 10 133315 150 46552587
Petechiae 21.28 9.70 82 133243 12588 46540149
Gait inability 21.03 9.70 43 133282 35160 46517577
Scedosporium infection 21.02 9.70 15 133310 511 46552226
Gamma-glutamyltransferase increased 21.02 9.70 159 133166 31581 46521156
Paraesthesia 21.01 9.70 224 133101 117213 46435524
Renal transplant 20.79 9.70 22 133303 1283 46551454
Antithrombin III decreased 20.72 9.70 12 133313 283 46552454
Dyspnoea 20.46 9.70 1235 132090 514313 46038424
Reticulocytopenia 20.39 9.70 8 133317 75 46552662
Cardiovascular disorder 20.11 9.70 5 133320 12182 46540555
Amnesia 20 9.70 57 133268 41574 46511163
Rash morbilliform 20.00 9.70 33 133292 2976 46549761
Autoimmune haemolytic anaemia 19.79 9.70 40 133285 4218 46548519
Respiratory arrest 19.61 9.70 42 133283 33774 46518963
Cytomegalovirus hepatitis 19.61 9.70 12 133313 314 46552423
Injection site urticaria 19.57 9.70 5 133320 11962 46540775
Fibromyalgia 19.48 9.70 174 133151 36289 46516448
Exostosis 19.47 9.70 3 133322 10260 46542477
Nephropathy toxic 19.46 9.70 56 133269 7398 46545339
HIV infection 19.41 9.70 15 133310 578 46552159
Irritable bowel syndrome 19.40 9.70 96 133229 16419 46536318
Contraindicated product administered 19.39 9.70 141 133184 79806 46472931
Muscle spasms 19.24 9.70 242 133083 122871 46429866
Dermo-hypodermitis 19.20 9.70 11 133314 254 46552483
Pulmonary mucormycosis 19.18 9.70 8 133317 89 46552648
Escherichia urinary tract infection 19.16 9.70 69 133256 10254 46542483
Alanine aminotransferase increased 19.14 9.70 357 132968 88094 46464643
Hyperhidrosis 19.10 9.70 163 133162 89145 46463592
Cytokine storm 19.05 9.70 11 133314 258 46552479
Sleep disorder 19.04 9.70 69 133256 46726 46506011
Vomiting 19.03 9.70 1520 131805 451274 46101463
Cell-mediated immune deficiency 19.02 9.70 6 133319 27 46552710
Squamous cell carcinoma of skin 18.95 9.70 44 133281 5103 46547634
Coma 18.90 9.70 252 133073 58097 46494640
Drug level increased 18.77 9.70 103 133222 18338 46534399
Gastrointestinal disorder 18.76 9.70 256 133069 59320 46493417
Beta haemolytic streptococcal infection 18.73 9.70 25 133300 1864 46550873
Oesophageal candidiasis 18.65 9.70 44 133281 5156 46547581
Vitiligo 18.62 9.70 19 133306 1062 46551675
Candida sepsis 18.59 9.70 21 133304 1318 46551419
Acquired immunodeficiency syndrome 18.57 9.70 8 133317 97 46552640
Device dislocation 18.45 9.70 21 133304 21781 46530956
Pulmonary nocardiosis 18.35 9.70 8 133317 100 46552637
Device issue 18.30 9.70 18 133307 19962 46532775
Discomfort 18.22 9.70 70 133255 46600 46506137
Disseminated cryptococcosis 18.18 9.70 11 133314 282 46552455
Rheumatoid factor positive 18.09 9.70 19 133306 20442 46532295
Heart rate increased 18.09 9.70 132 133193 74659 46478078
Venoocclusive disease 18.05 9.70 25 133300 1931 46550806
Parkinsonian rest tremor 18.01 9.70 8 133317 105 46552632
Feeding disorder 17.97 9.70 67 133258 10127 46542610
Pneumocystis jirovecii infection 17.94 9.70 20 133305 1237 46551500
Conjunctivalisation 17.94 9.70 5 133320 13 46552724
Lung neoplasm malignant 17.93 9.70 11 133314 15478 46537259
Pruritus 17.92 9.70 855 132470 241497 46311240
Hyperthermia 17.90 9.70 57 133268 7957 46544780
Primary myelofibrosis 17.90 9.70 7 133318 65 46552672
Progressive multifocal leukoencephalopathy 17.90 9.70 72 133253 11274 46541463
Hot flush 17.82 9.70 64 133261 43453 46509284
Foot deformity 17.79 9.70 11 133314 15414 46537323
Asteatosis 17.71 9.70 7 133318 67 46552670
Device malfunction 17.69 9.70 8 133317 13366 46539371
Focal myositis 17.60 9.70 6 133319 36 46552701
Escherichia pyelonephritis 17.59 9.70 12 133313 380 46552357
Hypertensive cardiomyopathy 17.57 9.70 10 133315 228 46552509
Injection site haemorrhage 17.46 9.70 20 133305 20689 46532048
Laryngeal stenosis 17.42 9.70 15 133310 675 46552062
Tubulointerstitial nephritis 17.40 9.70 86 133239 14702 46538035
Ocular hyperaemia 17.39 9.70 106 133219 19604 46533133
Varicella zoster virus infection 17.36 9.70 27 133298 2316 46550421
Erythema multiforme 17.29 9.70 64 133261 9640 46543097
Pancreatitis acute 17.26 9.70 126 133199 24746 46527991
Rash macular 17.26 9.70 104 133221 19156 46533581
Cholesteatoma 17.23 9.70 8 133317 117 46552620
Immunosuppressant drug level decreased 17.19 9.70 17 133308 915 46551822
Renal failure 17.06 9.70 435 132890 113159 46439578
Dermatitis exfoliative 16.96 9.70 45 133280 5671 46547066
Chorioretinitis 16.94 9.70 11 133314 320 46552417
Enteritis infectious 16.88 9.70 25 133300 2054 46550683
Meningoencephalitis herpetic 16.87 9.70 18 133307 1060 46551677
Joint injury 16.80 9.70 18 133307 19191 46533546
Umbilical erythema 16.78 9.70 7 133318 78 46552659
Renal tubular necrosis 16.75 9.70 68 133257 10691 46542046
Acute lymphocytic leukaemia recurrent 16.73 9.70 25 133300 2070 46550667
Oropharyngeal candidiasis 16.67 9.70 17 133308 949 46551788
Escherichia infection 16.55 9.70 68 133257 10749 46541988
Parvovirus B19 infection 16.53 9.70 11 133314 334 46552403
Bradycardia 16.52 9.70 116 133209 66182 46486555
Post transplant lymphoproliferative disorder 16.49 9.70 35 133290 3821 46548916
Depressed mood 16.47 9.70 45 133280 33274 46519463
Condition aggravated 16.45 9.70 554 132771 244498 46308239
Mouth swelling 16.37 9.70 34 133291 3655 46549082
Respiratory syncytial virus infection 16.36 9.70 40 133285 4795 46547942
Haemolysis 16.28 9.70 46 133279 6013 46546724
Hyperbilirubinaemia 16.27 9.70 66 133259 10372 46542365
Malaise 16.18 9.70 777 132548 330455 46222282
Lung disorder 16.15 9.70 192 133133 43112 46509625
Adenovirus infection 16.14 9.70 29 133296 2801 46549936
Potentiating drug interaction 16.08 9.70 35 133290 3888 46548849
Flank pain 16.00 9.70 72 133253 11841 46540896
Terminal ileitis 16.00 9.70 8 133317 139 46552598
Hepatitis fulminant 15.86 9.70 32 133293 3370 46549367
Road traffic accident 15.86 9.70 27 133298 23664 46529073
Respiratory tract infection viral 15.82 9.70 23 133302 1858 46550879
Diffuse alveolar damage 15.66 9.70 15 133310 776 46551961
Flushing 15.64 9.70 114 133211 64500 46488237
Chronic lymphocytic leukaemia 15.63 9.70 29 133296 2871 46549866
Labelled drug-drug interaction medication error 15.51 9.70 59 133266 9002 46543735
Eye infection toxoplasmal 15.49 9.70 10 133315 288 46552449
Hypertension 15.35 9.70 435 132890 195921 46356816
Myalgia 15.35 9.70 253 133072 122835 46429902
Documented hypersensitivity to administered product 15.34 9.70 13 133312 572 46552165
Synovial cyst 15.29 9.70 51 133274 7295 46545442
Pneumococcal infection 15.21 9.70 11 133314 383 46552354
Deafness 15.20 9.70 88 133237 15980 46536757
Granulomatosis with polyangiitis 15.11 9.70 22 133303 1780 46550957
Diabetic eye disease 15.08 9.70 8 133317 158 46552579
Mucormycosis 15.05 9.70 25 133300 2267 46550470
JC virus infection 14.98 9.70 21 133304 1641 46551096
Palmar-plantar erythrodysaesthesia syndrome 14.93 9.70 22 133303 20429 46532308
Hyperammonaemia 14.89 9.70 38 133287 4678 46548059
Product complaint 14.86 9.70 8 133317 12093 46540644
Immunoglobulins decreased 14.81 9.70 15 133310 831 46551906
Gastric disorder 14.80 9.70 34 133291 26671 46526066
Cytomegalovirus syndrome 14.80 9.70 7 133318 107 46552630
Liver transplant rejection 14.80 9.70 19 133306 1364 46551373
Microsporidia infection 14.76 9.70 9 133316 234 46552503
Cataract 14.75 9.70 73 133252 45342 46507395
Disseminated varicella zoster vaccine virus infection 14.69 9.70 6 133319 63 46552674
Pain in jaw 14.69 9.70 58 133267 38314 46514423
Chest discomfort 14.64 9.70 176 133149 90093 46462644
Limb injury 14.62 9.70 20 133305 19154 46533583
Metastases to bone 14.60 9.70 17 133308 17459 46535278
Osteoporosis 14.54 9.70 63 133262 40545 46512192
Cachexia 14.46 9.70 38 133287 4761 46547976
Hypersensitivity pneumonitis 14.41 9.70 25 133300 2348 46550389
Steroid diabetes 14.40 9.70 13 133312 623 46552114
Acinetobacter infection 14.38 9.70 19 133306 1403 46551334
Medication error 14.36 9.70 43 133282 30868 46521869
Tooth disorder 14.31 9.70 28 133297 23275 46529462
Anorexia nervosa 14.31 9.70 8 133317 176 46552561
Liver disorder 14.27 9.70 166 133159 37080 46515657
Therapeutic response decreased 14.22 9.70 69 133256 43076 46509661
Disseminated intravascular coagulation 14.19 9.70 98 133227 18907 46533830
Hypertensive crisis 14.00 9.70 11 133314 13604 46539133
Therapy cessation 13.89 9.70 35 133290 26594 46526143
Fluid retention 13.88 9.70 87 133238 50959 46501778
Parainfluenzae virus infection 13.84 9.70 21 133304 1763 46550974
Vaginal ulceration 13.83 9.70 10 133315 348 46552389
Cystitis haemorrhagic 13.81 9.70 31 133294 3516 46549221
Septal panniculitis 13.77 9.70 6 133319 75 46552662
Bandaemia 13.66 9.70 5 133320 38 46552699
Musculoskeletal discomfort 13.65 9.70 12 133313 14044 46538693
Systemic mycosis 13.64 9.70 15 133310 914 46551823
Blindness cortical 13.63 9.70 11 133314 452 46552285
Multiple sclerosis relapse 13.52 9.70 68 133257 42057 46510680
Cardiac disorder 13.40 9.70 72 133253 43786 46508951
Multiple sclerosis 13.39 9.70 32 133293 24759 46527978
Mood swings 13.38 9.70 16 133309 16236 46536501
Serotonin syndrome 13.29 9.70 31 133294 24189 46528548
Dermatitis bullous 13.27 9.70 50 133275 7593 46545144
Tooth abscess 13.25 9.70 10 133315 12623 46540114
Schizophrenia 13.23 9.70 4 133321 8564 46544173
Clubbing 13.22 9.70 9 133316 284 46552453
Swelling face 13.21 9.70 219 133106 52840 46499897
Myoclonus 13.18 9.70 78 133247 14274 46538463
Excessive eye blinking 13.16 9.70 12 133313 583 46552154
Tumour flare 13.11 9.70 9 133316 288 46552449
Spinal stenosis 13.06 9.70 10 133315 12533 46540204
Diffuse large B-cell lymphoma 13.05 9.70 42 133283 5896 46546841
Asthenia 13.04 9.70 741 132584 310334 46242403
Therapeutic product effect decreased 13.04 9.70 162 133163 82439 46470298
Anger 12.93 9.70 9 133316 11843 46540894
Chemical burn of oral cavity 12.91 9.70 6 133319 88 46552649
Pregnancy with injectable contraceptive 12.90 9.70 7 133318 145 46552592
Hepatosplenomegaly 12.86 9.70 24 133301 2386 46550351
Temperature intolerance 12.79 9.70 3 133322 7604 46545133
Neck pain 12.71 9.70 99 133226 55207 46497530
Face oedema 12.71 9.70 96 133229 19057 46533680
Coronavirus infection 12.69 9.70 26 133299 2768 46549969
Surgery 12.69 9.70 41 133284 28744 46523993
Haemolytic transfusion reaction 12.68 9.70 4 133321 18 46552719
Pelvic venous thrombosis 12.67 9.70 19 133306 1578 46551159
Urticaria 12.66 9.70 433 132892 117459 46435278
Chronic lymphocytic leukaemia refractory 12.64 9.70 5 133320 48 46552689
Staphylococcal infection 12.64 9.70 157 133168 35614 46517123
Vulvovaginal candidiasis 12.64 9.70 25 133300 2596 46550141
Culture stool positive 12.60 9.70 9 133316 307 46552430
Pneumonia pseudomonal 12.55 9.70 22 133303 2084 46550653
Device related bacteraemia 12.50 9.70 4 133321 19 46552718
Skin ulcer 12.46 9.70 49 133276 32409 46520328
Herpes zoster 12.36 9.70 267 133058 67605 46485132
Peripheral motor neuropathy 12.35 9.70 18 133307 1458 46551279
Soft tissue swelling 12.33 9.70 14 133311 884 46551853
Mucocutaneous ulceration 12.32 9.70 7 133318 159 46552578
Lipase increased 12.32 9.70 53 133272 8550 46544187
Gastrointestinal pain 12.32 9.70 48 133277 7407 46545330
Feeling hot 12.30 9.70 61 133264 37867 46514870
Insomnia 12.22 9.70 368 132957 164556 46388181
Herpes simplex viraemia 12.20 9.70 7 133318 162 46552575
Disability 12.08 9.70 7 133318 10160 46542577
Injection site induration 12.06 9.70 4 133321 8075 46544662
Disseminated sporotrichosis 12.02 9.70 4 133321 22 46552715
Skin irritation 12.00 9.70 3 133322 7284 46545453
Toothache 11.96 9.70 18 133307 16574 46536163
Urosepsis 11.96 9.70 80 133245 15273 46537464
Graft versus host disease in skin 11.93 9.70 23 133302 2344 46550393
Body mass index decreased 11.92 9.70 9 133316 335 46552402
Influenza like illness 11.90 9.70 106 133219 57464 46495273
Withdrawal syndrome 11.84 9.70 21 133304 18113 46534624
Deep vein thrombosis 11.83 9.70 305 133020 79468 46473269
Swelling 11.83 9.70 268 133057 124243 46428494
Polyneuropathy 11.82 9.70 65 133260 11579 46541158
Systemic inflammatory response syndrome 11.82 9.70 38 133287 5333 46547404
Haematuria 11.80 9.70 123 133202 26735 46526002
Amegakaryocytic thrombocytopenia 11.73 9.70 4 133321 24 46552713
Natural killer cell count 11.73 9.70 4 133321 24 46552713
Libido disorder 11.73 9.70 5 133320 59 46552678
Heart rate irregular 11.71 9.70 22 133303 18569 46534168
Oral mucosa erosion 11.70 9.70 15 133310 1075 46551662
Cerebral aspergillosis 11.69 9.70 9 133316 345 46552392
Obesity 11.68 9.70 14 133311 14192 46538545
Blastomycosis 11.68 9.70 8 133317 255 46552482
Gastroenteritis 11.64 9.70 113 133212 24106 46528631
Head injury 11.64 9.70 34 133291 24602 46528135
Wound 11.61 9.70 73 133252 42729 46510008
Syncope 11.60 9.70 220 133105 104583 46448154
Psychotic disorder 11.59 9.70 30 133295 22591 46530146
Hip fracture 11.59 9.70 38 133287 26518 46526219
Sciatica 11.56 9.70 23 133302 18997 46533740
Lower limb fracture 11.55 9.70 11 133314 12387 46540350
Hypoaesthesia oral 11.54 9.70 8 133317 10551 46542186
Abnormal behaviour 11.52 9.70 27 133298 21031 46531706
Human herpesvirus 6 encephalitis 11.52 9.70 6 133319 114 46552623
Blood loss anaemia 11.51 9.70 5 133320 8552 46544185
Throat irritation 11.50 9.70 43 133282 28858 46523879
Fungal infection 11.50 9.70 132 133193 29388 46523349
Pyelonephritis 11.36 9.70 79 133246 15278 46537459
Macrophages increased 11.33 9.70 4 133321 27 46552710
Urine output decreased 11.30 9.70 62 133263 11035 46541702
Pneumothorax 11.26 9.70 76 133249 14553 46538184
Chylothorax 11.25 9.70 8 133317 271 46552466
Serum sickness 11.19 9.70 23 133302 2455 46550282
Heart transplant rejection 11.17 9.70 10 133315 474 46552263
Respiratory depression 11.15 9.70 10 133315 11590 46541147
Rash papular 11.15 9.70 69 133256 12829 46539908
Hepatic infarction 11.11 9.70 11 133314 593 46552144
Skin erosion 11.10 9.70 22 133303 2287 46550450
Oral pain 11.10 9.70 114 133211 24683 46528054
Injection site discolouration 11.08 9.70 3 133322 6907 46545830
Stenotrophomonas infection 11.08 9.70 18 133307 1602 46551135
Musculoskeletal stiffness 11.07 9.70 205 133120 97788 46454949
C-reactive protein abnormal 11.06 9.70 28 133297 21242 46531495
Hepatitis cholestatic 11.04 9.70 43 133282 6634 46546103
Panic attack 11.04 9.70 26 133299 20216 46532521
Nightmare 11.03 9.70 19 133306 16579 46536158
Dysgeusia 11.02 9.70 69 133256 40422 46512315
Blood HIV RNULL 10.99 9.70 3 133322 7 46552730
Central nervous system necrosis 10.98 9.70 6 133319 126 46552611
Viral haemorrhagic cystitis 10.97 9.70 11 133314 602 46552135
Wrist fracture 10.96 9.70 10 133315 11493 46541244
Confusional state 10.95 9.70 560 132765 159332 46393405
Nervousness 10.93 9.70 43 133282 28432 46524305
Glycosylated haemoglobin increased 10.91 9.70 9 133316 10867 46541870
Hypertransaminasaemia 10.90 9.70 28 133297 3460 46549277
Limbal swelling 10.86 9.70 4 133321 31 46552706
Transient ischaemic attack 10.83 9.70 57 133268 34846 46517891
Shoulder arthroplasty 10.82 9.70 26 133299 3082 46549655
Klebsiella bacteraemia 10.81 9.70 15 133310 1161 46551576
Weight decreased 10.80 9.70 492 132833 210357 46342380
Photodermatosis 10.78 9.70 9 133316 388 46552349
Campylobacter gastroenteritis 10.76 9.70 9 133316 389 46552348
Hyperglycaemia 10.75 9.70 150 133175 34921 46517816
Cystitis 10.75 9.70 175 133150 42066 46510671
Lichenification 10.74 9.70 9 133316 390 46552347
Post procedural bile leak 10.73 9.70 6 133319 132 46552605
Ureteric obstruction 10.72 9.70 19 133306 1815 46550922
Breast cancer metastatic 10.70 9.70 14 133311 13664 46539073
Haematochezia 10.67 9.70 63 133262 37430 46515307
Blood lactate dehydrogenase decreased 10.66 9.70 5 133320 75 46552662
Blood pressure diastolic decreased 10.66 9.70 15 133310 14196 46538541
Nasal congestion 10.65 9.70 87 133238 48026 46504711
Superinfection bacterial 10.60 9.70 9 133316 397 46552340
Hypoglycaemic seizure 10.59 9.70 10 133315 508 46552229
Diabetic macroangiopathy 10.57 9.70 6 133319 136 46552601
Investigation abnormal 10.57 9.70 14 133311 1036 46551701
Abortion spontaneous 10.57 9.70 77 133248 43569 46509168
Intervertebral disc protrusion 10.51 9.70 27 133298 20378 46532359
Genital burning sensation 10.50 9.70 7 133318 213 46552524
Vestibular disorder 10.48 9.70 16 133309 1350 46551387
Neonatal pneumonia 10.45 9.70 3 133322 9 46552728
Cheilitis 10.45 9.70 30 133295 3958 46548779
Opportunistic infection 10.44 9.70 18 133307 1683 46551054
Blood alkaline phosphatase increased 10.42 9.70 165 133160 39444 46513293
Leukoencephalopathy 10.37 9.70 30 133295 3974 46548763
Product storage error 10.37 9.70 11 133314 11781 46540956
Tarsal tunnel syndrome 10.36 9.70 11 133314 644 46552093
Intracranial pressure increased 10.34 9.70 31 133294 4189 46548548
Crystalluria 10.34 9.70 9 133316 411 46552326
AIDS related complication 10.34 9.70 4 133321 36 46552701
Delusion 10.34 9.70 10 133315 11178 46541559
Apnoea 10.34 9.70 4 133321 7335 46545402
Candida infection 10.32 9.70 103 133222 22137 46530600
Brain oedema 10.32 9.70 66 133259 12412 46540325
Irritability 10.30 9.70 45 133280 28901 46523836
Emotional disorder 10.29 9.70 12 133313 12312 46540425
Lip ulceration 10.27 9.70 18 133307 1705 46551032
Mydriasis 10.26 9.70 9 133316 10544 46542193
Escherichia sepsis 10.26 9.70 31 133294 4207 46548530
Loss of personal independence in daily activities 10.25 9.70 109 133216 57074 46495663
Ligament sprain 10.19 9.70 9 133316 10510 46542227
Hyperferritinaemia 10.15 9.70 5 133320 84 46552653
Death neonatal 10.11 9.70 7 133318 227 46552510
Illness 10.10 9.70 12 133313 12212 46540525
Respiratory tract congestion 10.05 9.70 13 133312 12751 46539986
Genital erosion 10.05 9.70 6 133319 150 46552587
Antinuclear antibody positive 10.02 9.70 40 133285 6240 46546497
SJS-TEN overlap 10.01 9.70 6 133319 151 46552586
Renal lymphocele 9.99 9.70 5 133320 87 46552650
Band sensation 9.99 9.70 11 133314 671 46552066
Gynaecological chlamydia infection 9.97 9.70 4 133321 40 46552697
Cytomegalovirus enterocolitis 9.96 9.70 10 133315 548 46552189
Increased appetite 9.95 9.70 6 133319 8521 46544216
Intracranial tumour haemorrhage 9.94 9.70 6 133319 153 46552584
Cardiac arrest 9.93 9.70 190 133135 90209 46462528
Tonsillar hypertrophy 9.90 9.70 12 133313 812 46551925
Cardiomegaly 9.90 9.70 22 133303 17460 46535277
Urticaria papular 9.88 9.70 4 133321 41 46552696
Basal cell carcinoma 9.88 9.70 28 133297 20459 46532278
Thrombotic thrombocytopenic purpura 9.85 9.70 29 133296 3881 46548856
Sedation 9.84 9.70 33 133292 22877 46529860
CD4 lymphocytes decreased 9.83 9.70 17 133308 1593 46551144
Hysterectomy 9.82 9.70 5 133320 7801 46544936
Gastrooesophageal reflux disease 9.82 9.70 280 133045 74064 46478673
Myeloid maturation arrest 9.79 9.70 3 133322 12 46552725
Lymphadenitis viral 9.79 9.70 3 133322 12 46552725
Carpal tunnel syndrome 9.79 9.70 19 133306 15840 46536897
Paronychia 9.77 9.70 32 133293 4534 46548203
Device breakage 9.75 9.70 8 133317 9684 46543053
Immune thrombocytopenia 9.75 9.70 48 133277 8193 46544544
Disseminated mycobacterium avium complex infection 9.71 9.70 4 133321 43 46552694

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pyrexia 527.91 10.11 2593 127240 291896 29530749
Drug reaction with eosinophilia and systemic symptoms 444.60 10.11 582 129251 27906 29794739
Febrile neutropenia 398.26 10.11 1189 128644 105504 29717141
Hyperkalaemia 339.07 10.11 828 129005 65182 29757463
Pancytopenia 322.07 10.11 953 128880 84099 29738546
Completed suicide 311.50 10.11 34 129799 99458 29723187
Pneumocystis jirovecii pneumonia 303.83 10.11 373 129460 16747 29805898
Cytomegalovirus infection 302.14 10.11 439 129394 23235 29799410
Drug abuse 296.91 10.11 14 129819 82058 29740587
Neutropenia 294.24 10.11 1219 128614 127321 29695324
Acute kidney injury 256.18 10.11 2043 127790 271799 29550846
Death 245.82 10.11 766 129067 356517 29466128
Immune reconstitution inflammatory syndrome 232.95 10.11 240 129593 8861 29813784
Thrombocytopenia 219.74 10.11 1172 128661 135872 29686773
Agranulocytosis 209.25 10.11 356 129477 21586 29801059
Rash maculo-papular 207.16 10.11 385 129448 25033 29797612
Toxicity to various agents 198.43 10.11 288 129545 176895 29645750
Nocardiosis 185.73 10.11 139 129694 3316 29819329
Stevens-Johnson syndrome 172.91 10.11 289 129544 17267 29805378
Cytomegalovirus viraemia 168.60 10.11 163 129670 5566 29817079
Myocardial infarction 161.40 10.11 184 129649 125441 29697204
Transplant rejection 160.76 10.11 199 129634 9007 29813638
Cytokine release syndrome 150.31 10.11 200 129633 9733 29812912
Leukopenia 147.86 10.11 557 129276 55602 29767043
Neutrophil count decreased 140.28 10.11 454 129379 42000 29780645
Intentional overdose 132.76 10.11 13 129820 41468 29781177
Drug ineffective 130.36 10.11 903 128930 339484 29483161
Dizziness 127.16 10.11 427 129406 194482 29628163
Hepatocellular injury 121.64 10.11 311 129522 25160 29797485
Aspergillus infection 116.81 10.11 180 129653 10034 29812611
Febrile bone marrow aplasia 111.86 10.11 156 129677 7941 29814704
Cholestasis 108.30 10.11 294 129539 24656 29797989
Bronchopulmonary aspergillosis 103.75 10.11 189 129644 12095 29810550
Fall 101.90 10.11 424 129409 181448 29641197
Cerebrovascular accident 100.00 10.11 129 129704 83348 29739297
Suicide attempt 99.77 10.11 19 129814 36678 29785967
Rash 94.94 10.11 1258 128575 190631 29632014
Lymphopenia 94.49 10.11 189 129644 12974 29809671
Fatigue 91.19 10.11 920 128913 319753 29502892
Pain 90.88 10.11 412 129421 172229 29650416
Platelet count decreased 89.63 10.11 775 129058 105354 29717291
Thrombotic microangiopathy 89.16 10.11 145 129688 8465 29814180
Rheumatoid arthritis 88.26 10.11 34 129799 41163 29781482
Product dose omission issue 85.70 10.11 167 129666 91464 29731181
Congenital umbilical hernia 84.62 10.11 39 129794 356 29822289
Cardiac failure congestive 84.11 10.11 148 129685 84259 29738386
Sepsis 83.15 10.11 985 128848 145410 29677235
Septic shock 80.22 10.11 511 129322 63096 29759549
Overdose 79.48 10.11 153 129680 84184 29738461
Toxic skin eruption 78.87 10.11 158 129675 10857 29811788
Kidney transplant rejection 78.49 10.11 127 129706 7382 29815263
Anxiety 77.95 10.11 171 129662 89700 29732945
Haemophagocytic lymphohistiocytosis 76.87 10.11 146 129687 9645 29813000
Coronary artery disease 76.34 10.11 62 129771 49650 29772995
Blood creatinine increased 75.95 10.11 665 129168 90710 29731935
Aplasia 74.91 10.11 90 129743 3947 29818698
Bone marrow failure 73.89 10.11 290 129543 29495 29793150
Depression 72.87 10.11 179 129654 90258 29732387
Acute febrile neutrophilic dermatosis 72.75 10.11 51 129782 1095 29821550
Dermatitis exfoliative generalised 69.80 10.11 73 129760 2742 29819903
Toxic epidermal necrolysis 69.61 10.11 203 129630 17737 29804908
Acute myocardial infarction 69.58 10.11 76 129757 52863 29769782
Chronic lymphocytic leukaemia 68.20 10.11 92 129741 4536 29818109
Lymphocyte count decreased 67.69 10.11 209 129624 18846 29803799
Pathogen resistance 66.75 10.11 126 129707 8284 29814361
Injection site pain 66.63 10.11 24 129809 30286 29792359
Pseudomonas infection 66.43 10.11 143 129690 10339 29812306
White blood cell count decreased 66.18 10.11 604 129229 83343 29739302
Rash morbilliform 65.86 10.11 67 129766 2435 29820210
Hepatitis 64.91 10.11 229 129604 22127 29800518
Pain in extremity 64.76 10.11 252 129581 109969 29712676
Product use in unapproved indication 64.72 10.11 543 129290 73150 29749495
Arthralgia 63.36 10.11 338 129495 135453 29687192
Graft versus host disease 62.64 10.11 137 129696 10013 29812632
Blood lactate dehydrogenase increased 60.65 10.11 212 129621 20389 29802256
Loss of consciousness 59.42 10.11 163 129670 79212 29743433
Therapeutic product effect decreased 59.03 10.11 26 129807 29050 29793595
Epstein-Barr virus infection 58.94 10.11 105 129728 6601 29816044
Candida infection 58.81 10.11 173 129660 15189 29807456
Cryptococcosis 58.23 10.11 54 129779 1748 29820897
Pneumonia cytomegaloviral 57.99 10.11 66 129767 2730 29819915
Psoriasis 56.99 10.11 60 129773 42446 29780199
Inappropriate schedule of product administration 56.81 10.11 53 129780 39675 29782970
Hypofibrinogenaemia 56.48 10.11 51 129782 1594 29821051
Chest pain 55.85 10.11 291 129542 117336 29705309
Polyomavirus-associated nephropathy 55.84 10.11 69 129764 3116 29819529
Aggression 55.46 10.11 47 129786 36860 29785785
Eosinophilia 55.15 10.11 216 129617 21944 29800701
Somnolence 55.07 10.11 224 129609 96539 29726106
Syncope 54.54 10.11 187 129646 84716 29737929
Renal tubular acidosis 53.91 10.11 52 129781 1770 29820875
Dermatitis exfoliative 53.44 10.11 107 129726 7349 29815296
Dyspnoea 53.39 10.11 1072 128761 332223 29490422
Blood pressure increased 52.87 10.11 149 129684 71779 29750866
Renal tubular necrosis 52.07 10.11 165 129668 15086 29807559
Squamous cell carcinoma of skin 51.92 10.11 119 129714 8976 29813669
BK virus infection 51.43 10.11 78 129755 4286 29818359
Infection reactivation 50.50 10.11 38 129795 914 29821731
Acute generalised exanthematous pustulosis 50.44 10.11 93 129740 6005 29816640
Feeling abnormal 50.01 10.11 107 129726 56649 29765996
Toxoplasmosis 49.56 10.11 39 129794 1004 29821641
Human herpesvirus 6 infection 48.95 10.11 51 129782 1907 29820738
Wrong technique in product usage process 48.90 10.11 38 129795 31117 29791528
Joint swelling 48.86 10.11 80 129753 46866 29775779
Drug dependence 48.29 10.11 16 129817 21279 29801366
Tumour lysis syndrome 48.27 10.11 144 129689 12741 29809904
Anaemia 47.08 10.11 1207 128626 206785 29615860
Immunosuppressant drug level increased 47.08 10.11 78 129755 4624 29818021
Pneumonia 46.98 10.11 1831 128002 332475 29490170
Encephalitis viral 46.80 10.11 40 129793 1160 29821485
Suicidal ideation 46.18 10.11 53 129780 36061 29786584
Cardiac arrest 46.17 10.11 226 129607 92624 29730021
Cardio-respiratory arrest 45.68 10.11 114 129719 57192 29765453
Sedation 45.52 10.11 8 129825 16365 29806280
Vanishing bile duct syndrome 45.39 10.11 31 129802 637 29822008
Intentional product misuse 45.29 10.11 50 129783 34617 29788028
Pneumonia fungal 44.04 10.11 83 129750 5450 29817195
Transaminases increased 44.04 10.11 210 129623 23247 29799398
Hepatitis cholestatic 43.83 10.11 102 129731 7770 29814875
Birth mark 43.74 10.11 21 129812 212 29822433
Pulmonary nocardiosis 43.51 10.11 25 129808 374 29822271
Tubulointerstitial nephritis 43.39 10.11 173 129660 17718 29804927
Plasma cell myeloma 43.29 10.11 387 129446 53075 29769570
Chest discomfort 43.26 10.11 82 129751 45398 29777247
Strongyloidiasis 43.03 10.11 52 129781 2294 29820351
Enterococcal infection 43.02 10.11 104 129729 8120 29814525
Product quality issue 42.76 10.11 14 129819 18760 29803885
Gait disturbance 42.60 10.11 173 129660 74604 29748041
Hyperhidrosis 42.25 10.11 149 129684 66941 29755704
Injury 41.70 10.11 21 129812 21710 29800935
Mycobacterium avium complex infection 41.64 10.11 55 129778 2656 29819989
Transplant dysfunction 41.31 10.11 51 129782 2301 29820344
Neuroleptic malignant syndrome 41.10 10.11 10 129823 16285 29806360
Complications of transplanted kidney 41.02 10.11 68 129765 4033 29818612
Weight increased 41.01 10.11 176 129657 74737 29747908
Pneumonia bacterial 40.99 10.11 111 129722 9292 29813353
Microsporidia infection 40.97 10.11 28 129805 576 29822069
Drug hypersensitivity 40.57 10.11 465 129368 68054 29754591
Blood glucose increased 40.54 10.11 134 129699 61396 29761249
Dysplastic naevus 40.44 10.11 23 129810 337 29822308
Bradycardia 40.28 10.11 147 129686 65379 29757266
Stress 39.67 10.11 19 129814 20216 29802429
Mucormycosis 39.44 10.11 77 129756 5191 29817454
Psoriatic arthropathy 39.12 10.11 10 129823 15751 29806894
Adenovirus infection 39.03 10.11 68 129765 4200 29818445
Multiple organ dysfunction syndrome 39.01 10.11 434 129399 63053 29759592
Chronic obstructive pulmonary disease 38.95 10.11 89 129744 46037 29776608
Photodermatosis 38.94 10.11 24 129809 411 29822234
Rhinovirus infection 38.83 10.11 55 129778 2840 29819805
Parainfluenzae virus infection 38.74 10.11 46 129787 1992 29820653
Back pain 38.62 10.11 273 129560 102323 29720322
Hypogammaglobulinaemia 38.39 10.11 76 129757 5176 29817469
Drug withdrawal syndrome 38.22 10.11 19 129814 19790 29802855
Aplastic anaemia 37.76 10.11 78 129755 5478 29817167
Liver transplant rejection 37.54 10.11 47 129786 2151 29820494
Respiratory arrest 37.34 10.11 43 129790 29215 29793430
Insomnia 37.29 10.11 244 129589 93092 29729553
Lymphadenopathy 37.23 10.11 206 129627 24170 29798475
Headache 36.89 10.11 562 129271 181744 29640901
Malaise 36.82 10.11 506 129327 166456 29656189
Face oedema 36.31 10.11 120 129713 11214 29811431
Solar lentigo 36.27 10.11 21 129812 319 29822326
Device related infection 36.16 10.11 158 129675 16857 29805788
Trichophytosis 35.59 10.11 20 129813 286 29822359
Autoimmune haemolytic anaemia 34.96 10.11 63 129770 3996 29818649
Respiratory failure 34.32 10.11 620 129213 100022 29722623
Gastrointestinal haemorrhage 33.92 10.11 217 129616 83229 29739416
Sopor 33.74 10.11 4 129829 10987 29811658
Sleep disorder 33.43 10.11 34 129799 24445 29798200
Cardiac disorder 32.86 10.11 78 129755 39815 29782830
Actinic keratosis 32.42 10.11 57 129776 3546 29819099
Agitation 32.13 10.11 123 129710 53950 29768695
Hepatic function abnormal 32.11 10.11 300 129533 41645 29781000
Haemolytic anaemia 32.09 10.11 106 129727 9904 29812741
Asthma 32.02 10.11 68 129765 36106 29786539
Memory impairment 31.98 10.11 71 129762 37103 29785542
Cytomegalovirus test positive 31.94 10.11 57 129776 3588 29819057
Jarisch-Herxheimer reaction 31.55 10.11 21 129812 413 29822232
Paracoccidioides infection 31.52 10.11 13 129820 88 29822557
Erectile dysfunction 31.14 10.11 20 129813 18082 29804563
Gamma-glutamyltransferase increased 31.12 10.11 226 129607 29124 29793521
Pneumonia pseudomonal 30.81 10.11 55 129778 3463 29819182
Asthenia 30.63 10.11 728 129105 220562 29602083
Renal impairment 30.61 10.11 524 129309 83660 29738985
Haematochezia 30.57 10.11 64 129769 34158 29788487
Disseminated cryptococcosis 30.24 10.11 29 129804 980 29821665
Therapeutic product effect incomplete 29.61 10.11 64 129769 33770 29788875
Photosensitivity reaction 29.61 10.11 101 129732 9593 29813052
Lymphocele 29.50 10.11 34 129799 1426 29821219
Hyperferritinaemia 29.16 10.11 19 129814 360 29822285
Microangiopathic haemolytic anaemia 29.05 10.11 26 129807 803 29821842
Fusarium infection 28.93 10.11 29 129804 1035 29821610
Rash erythematous 28.66 10.11 181 129652 22271 29800374
Contusion 28.36 10.11 58 129775 31222 29791423
Nephropathy toxic 28.35 10.11 106 129727 10533 29812112
Immune effector cell-associated neurotoxicity syndrome 28.33 10.11 26 129807 830 29821815
Hypoalbuminaemia 28.31 10.11 109 129724 10983 29811662
Cytomegalovirus enteritis 28.05 10.11 19 129814 385 29822260
Fungal skin infection 28.00 10.11 43 129790 2389 29820256
Mucosal inflammation 27.97 10.11 227 129606 30267 29792378
Cystitis haemorrhagic 27.72 10.11 63 129770 4724 29817921
Delayed graft function 27.67 10.11 36 129797 1713 29820932
Oral candidiasis 27.61 10.11 108 129725 10963 29811682
Hepatosplenomegaly 27.59 10.11 54 129779 3647 29818998
Musculoskeletal stiffness 27.34 10.11 73 129760 35808 29786837
Reticulocytosis 27.34 10.11 17 129816 296 29822349
Purpura 27.14 10.11 100 129733 9867 29812778
Arthropathy 26.95 10.11 30 129803 20697 29801948
Hyperleukocytosis 26.84 10.11 34 129799 1575 29821070
Progressive multifocal leukoencephalopathy 26.74 10.11 93 129740 8920 29813725
Fear 26.61 10.11 7 129826 10818 29811827
Crystalluria 26.56 10.11 18 129815 365 29822280
Epidermal necrosis 26.32 10.11 19 129814 428 29822217
Hypertriglyceridaemia 26.18 10.11 86 129747 8012 29814633
Depressed level of consciousness 26.03 10.11 82 129751 38140 29784505
Erythema multiforme 25.99 10.11 85 129748 7900 29814745
Flushing 25.63 10.11 56 129777 29436 29793209
Hypertension 25.58 10.11 371 129462 120983 29701662
Post transplant lymphoproliferative disorder 25.54 10.11 65 129768 5241 29817404
Abdominal discomfort 25.26 10.11 117 129716 48674 29773971
Idiopathic pulmonary fibrosis 25.19 10.11 55 129778 4014 29818631
Blood fibrinogen decreased 25.15 10.11 26 129807 963 29821682
Hepatomegaly 25.05 10.11 98 129735 9949 29812696
Poisoning 25.03 10.11 9 129824 11373 29811272
Pre-engraftment immune reaction 25.01 10.11 11 129822 89 29822556
Brain abscess 24.89 10.11 43 129790 2638 29820007
Klebsiella infection 24.88 10.11 76 129757 6811 29815834
Upper respiratory tract inflammation 24.87 10.11 35 129798 1796 29820849
Myocardial ischaemia 24.87 10.11 23 129810 17294 29805351
Device malfunction 24.78 10.11 3 129830 8108 29814537
Lung transplant rejection 24.68 10.11 23 129810 749 29821896
Pyelonephritis 24.60 10.11 65 129768 5361 29817284
Muscle rigidity 24.54 10.11 7 129826 10254 29812391
Cytomegalovirus colitis 24.54 10.11 40 129793 2339 29820306
Osteoarthritis 24.48 10.11 26 129807 18323 29804322
Drug-induced liver injury 23.82 10.11 166 129667 21108 29801537
Neuropathy peripheral 23.60 10.11 433 129400 70042 29752603
Infection 23.52 10.11 472 129361 77602 29745043
Liver transplant 23.51 10.11 43 129790 2759 29819886
Hallucination 23.46 10.11 121 129712 48938 29773707
Blood urea increased 23.29 10.11 223 129610 31158 29791487
Weight decreased 23.27 10.11 488 129345 150433 29672212
Organising pneumonia 23.23 10.11 61 129772 5013 29817632
Multiple sclerosis relapse 23.20 10.11 9 129824 10853 29811792
Genital erythema 23.12 10.11 12 129821 145 29822500
Aplasia pure red cell 23.12 10.11 65 129768 5561 29817084
Dyspepsia 22.88 10.11 62 129771 30267 29792378
Blood creatine phosphokinase increased 22.79 10.11 105 129728 43743 29778902
Alanine aminotransferase increased 22.69 10.11 450 129383 73826 29748819
Acanthamoeba infection 22.69 10.11 18 129815 469 29822176
Arteriosclerosis coronary artery 22.67 10.11 10 129823 11166 29811479
Serum sickness 22.53 10.11 33 129800 1757 29820888
Pneumonia influenzal 22.27 10.11 28 129805 1287 29821358
Meningitis cryptococcal 22.20 10.11 35 129798 1989 29820656
Type 2 diabetes mellitus 22.16 10.11 16 129817 13606 29809039
Escherichia urinary tract infection 22.12 10.11 43 129790 2889 29819756
Bacteraemia 22.11 10.11 129 129704 15431 29807214
Rhabdomyolysis 22.08 10.11 173 129660 63407 29759238
Isosporiasis 22.01 10.11 10 129823 88 29822557
Liver disorder 21.95 10.11 211 129622 29511 29793134
Intentional self-injury 21.88 10.11 16 129817 13516 29809129
Road traffic accident 21.88 10.11 25 129808 17046 29805599
Herpes simplex 21.81 10.11 55 129778 4409 29818236
Vision blurred 21.81 10.11 100 129733 41716 29780929
Oesophageal candidiasis 21.76 10.11 53 129780 4157 29818488
Depressed mood 21.76 10.11 25 129808 17004 29805641
Glycosylated haemoglobin increased 21.75 10.11 7 129826 9484 29813161
Hyperuricaemia 21.68 10.11 76 129757 7318 29815327
Cerebral aspergillosis 21.56 10.11 28 129805 1330 29821315
Pneumonia pneumococcal 21.48 10.11 33 129800 1834 29820811
Hypotension 21.47 10.11 684 129149 199881 29622764
Nasopharyngitis 21.44 10.11 158 129675 58691 29763954
Kidney fibrosis 21.43 10.11 35 129798 2050 29820595
Pericarditis fungal 21.33 10.11 12 129821 172 29822473
Drug resistance 21.32 10.11 155 129678 19978 29802667
Sleep apnoea syndrome 21.27 10.11 25 129808 16832 29805813
Aphthous ulcer 21.27 10.11 52 129781 4089 29818556
Contraindicated product administered 21.26 10.11 26 129807 17205 29805440
Pseudomonal bacteraemia 21.09 10.11 22 129811 824 29821821
Coronary artery occlusion 21.08 10.11 11 129822 11146 29811499
Obliterative bronchiolitis 21.08 10.11 26 129807 1172 29821473
Serotonin syndrome 21.04 10.11 28 129805 17863 29804782
Extrapyramidal disorder 21.02 10.11 10 129823 10683 29811962
Vogt-Koyanagi-Harada disease 20.99 10.11 9 129824 68 29822577
Transient ischaemic attack 20.97 10.11 49 129784 25151 29797494
Palpitations 20.83 10.11 75 129758 33498 29789147
Graft versus host disease in skin 20.82 10.11 45 129788 3262 29819383
Diffuse large B-cell lymphoma 20.79 10.11 78 129755 7763 29814882
Cheilitis 20.70 10.11 36 129797 2220 29820425
Medication error 20.66 10.11 37 129796 20935 29801710
Hyperbilirubinaemia 20.65 10.11 135 129698 16807 29805838
Angina unstable 20.63 10.11 14 129819 12296 29810349
Accidental exposure to product 20.60 10.11 9 129824 10106 29812539
Granuloma 20.44 10.11 37 129796 2355 29820290
Blood antidiuretic hormone increased 20.44 10.11 9 129824 73 29822572
Balance disorder 20.41 10.11 85 129748 36408 29786237
Coma 20.35 10.11 98 129735 40351 29782294
Product substitution issue 20.32 10.11 9 129824 10026 29812619
Loss of personal independence in daily activities 20.32 10.11 39 129794 21496 29801149
Pneumocystis jirovecii infection 20.22 10.11 27 129806 1318 29821327
Necrotising retinitis 20.16 10.11 20 129813 705 29821940
Conjunctivalisation 20.13 10.11 6 129827 12 29822633
Arteriosclerosis 20.00 10.11 11 129822 10822 29811823
Hyponatraemia 19.81 10.11 405 129428 66797 29755848
Acquired immunodeficiency syndrome 19.78 10.11 17 129816 497 29822148
Oroantral fistula 19.74 10.11 13 129820 251 29822394
Head injury 19.64 10.11 27 129806 16993 29805652
Restlessness 19.57 10.11 43 129790 22556 29800089
Injection site bruising 19.52 10.11 4 129829 7334 29815311
Scopulariopsis infection 19.47 10.11 10 129823 118 29822527
Cytomegalovirus enterocolitis 19.44 10.11 21 129812 819 29821826
Gastrooesophageal reflux disease 19.39 10.11 73 129760 32182 29790463
Blood pressure decreased 19.33 10.11 122 129711 46953 29775692
Drug eruption 19.18 10.11 136 129697 17390 29805255
Pseudomembranous colitis 19.18 10.11 40 129793 2828 29819817
Haemorrhage 19.13 10.11 119 129714 45960 29776685
Unevaluable event 19.07 10.11 72 129761 31713 29790932
Cytomegalovirus chorioretinitis 18.92 10.11 43 129790 3225 29819420
Renal tubular disorder 18.80 10.11 56 129777 4950 29817695
Granulomatous dermatitis 18.76 10.11 12 129821 220 29822425
Meningitis aseptic 18.69 10.11 35 129798 2287 29820358
Bicytopenia 18.68 10.11 30 129803 1732 29820913
Hepatitis fulminant 18.68 10.11 48 129785 3893 29818752
Dermatophytosis 18.62 10.11 12 129821 223 29822422
Migraine 18.60 10.11 17 129816 12857 29809788
Urinary tract infection 18.56 10.11 434 129399 73225 29749420
Enterococcal sepsis 18.44 10.11 28 129805 1540 29821105
Acute graft versus host disease in skin 18.38 10.11 52 129781 4464 29818181
Delusion 18.34 10.11 15 129818 11974 29810671
Mobility decreased 18.25 10.11 55 129778 25944 29796701
Proteus infection 18.09 10.11 19 129814 717 29821928
Nephrogenic diabetes insipidus 18.01 10.11 24 129809 1169 29821476
Synovitis 17.96 10.11 10 129823 9773 29812872
Rectal haemorrhage 17.95 10.11 84 129749 34855 29787790
Cytomegalovirus infection reactivation 17.91 10.11 29 129804 1686 29820959
Pulmonary mucormycosis 17.87 10.11 15 129818 424 29822221
Polyomavirus viraemia 17.83 10.11 16 129817 496 29822149
Enterovirus infection 17.81 10.11 17 129816 571 29822074
Palmar-plantar erythrodysaesthesia syndrome 17.76 10.11 23 129810 14847 29807798
Demodicidosis 17.68 10.11 10 129823 145 29822500
Blood HIV RNULL increased 17.67 10.11 26 129807 1390 29821255
Tumour flare 17.51 10.11 16 129817 508 29822137
Therapeutic response decreased 17.46 10.11 51 129782 24298 29798347
Hypersensitivity myocarditis 17.46 10.11 8 129825 72 29822573
Pneumonitis 17.45 10.11 189 129644 27265 29795380
Protothecosis 17.41 10.11 7 129826 44 29822601
Splenomegaly 17.40 10.11 109 129724 13371 29809274
Tooth deposit 17.39 10.11 9 129824 108 29822537
Osteoporotic fracture 17.33 10.11 22 129811 1021 29821624
Jaundice 17.25 10.11 216 129617 32270 29790375
Chills 17.25 10.11 423 129410 71915 29750730
Prostatic specific antigen increased 17.17 10.11 16 129817 11988 29810657
Leukaemia recurrent 17.13 10.11 27 129806 1534 29821111
Lung infiltration 17.13 10.11 103 129730 12456 29810189
Klebsiella bacteraemia 17.10 10.11 22 129811 1035 29821610
Encephalitis 17.04 10.11 64 129769 6372 29816273
Clostridium difficile infection 17.00 10.11 122 129711 15661 29806984
Schizophrenia 16.98 10.11 9 129824 9039 29813606
Product prescribing error 16.95 10.11 29 129804 16704 29805941
Folliculitis 16.91 10.11 44 129789 3596 29819049
Arthritis 16.86 10.11 52 129781 24349 29798296
Infective thrombosis 16.82 10.11 8 129825 79 29822566
Abnormal behaviour 16.73 10.11 56 129777 25567 29797078
CD4 lymphocytes increased 16.71 10.11 12 129821 268 29822377
Muscle spasms 16.70 10.11 190 129643 64648 29757997
Neurotoxicity 16.65 10.11 106 129727 13076 29809569
Fracture 16.55 10.11 3 129830 6003 29816642
Klebsiella sepsis 16.54 10.11 28 129805 1689 29820956
Achromobacter infection 16.54 10.11 7 129826 51 29822594
Conjunctival irritation 16.50 10.11 9 129824 121 29822524
Neck pain 16.42 10.11 42 129791 20902 29801743
Escherichia infection 16.39 10.11 63 129770 6342 29816303
Cardiovascular disorder 16.38 10.11 14 129819 10938 29811707
Cytopenia 16.29 10.11 75 129758 8181 29814464
Pulmonary alveolar haemorrhage 16.25 10.11 64 129769 6517 29816128
Immune reconstitution inflammatory syndrome associated tuberculosis 16.24 10.11 14 129819 411 29822234
Respiratory tract infection fungal 16.09 10.11 17 129816 646 29821999
Hypoaldosteronism 16.04 10.11 10 129823 175 29822470
Mantle cell lymphoma 16.02 10.11 26 129807 1515 29821130
Hypoxia 16.00 10.11 294 129539 47560 29775085
Pulmonary sarcoidosis 15.99 10.11 16 129817 570 29822075
Polymyositis 15.99 10.11 25 129808 1411 29821234
Disseminated trichosporonosis 15.98 10.11 7 129826 56 29822589
Injection site haemorrhage 15.98 10.11 7 129826 7848 29814797
Fungaemia 15.97 10.11 32 129801 2199 29820446
C-reactive protein increased 15.93 10.11 271 129562 43202 29779443
Skull malformation 15.90 10.11 13 129820 354 29822291
HIV infection 15.81 10.11 27 129806 1641 29821004
Streptococcal bacteraemia 15.78 10.11 27 129806 1643 29821002
Unresponsive to stimuli 15.75 10.11 60 129773 26359 29796286
Staphylococcal infection 15.64 10.11 200 129633 30024 29792621
Musculoskeletal discomfort 15.63 10.11 4 129829 6296 29816349
Myalgia 15.58 10.11 236 129597 76431 29746214
Cerebral toxoplasmosis 15.52 10.11 25 129808 1447 29821198
Dyspnoea exertional 15.50 10.11 90 129743 35340 29787305
Renal tubular atrophy 15.48 10.11 21 129812 1041 29821604
Vascular pseudoaneurysm thrombosis 15.37 10.11 7 129826 62 29822583
Lung disorder 15.35 10.11 206 129627 31263 29791382
Gastroenteritis cryptosporidial 15.28 10.11 10 129823 191 29822454
Lymphadenitis 15.20 10.11 27 129806 1693 29820952
Mycobacterial infection 15.19 10.11 27 129806 1694 29820951
Serum ferritin increased 15.18 10.11 55 129778 5382 29817263
Gastritis fungal 15.18 10.11 8 129825 100 29822545
Atypical mycobacterial infection 15.15 10.11 18 129815 780 29821865
Premature baby 15.08 10.11 31 129802 16660 29805985
Chronic papillomatous dermatitis 14.99 10.11 7 129826 66 29822579
Eye infection fungal 14.95 10.11 12 129821 318 29822327
Platelet transfusion 14.95 10.11 20 129813 978 29821667
Lichenoid keratosis 14.94 10.11 30 129803 2064 29820581
Peripheral swelling 14.94 10.11 181 129652 60893 29761752
Injection site erythema 14.93 10.11 23 129810 13811 29808834
Hepatitis A 14.90 10.11 14 129819 461 29822184
Swelling 14.89 10.11 93 129740 35882 29786763
Phlebitis infective 14.87 10.11 9 129824 149 29822496
Nephritis 14.78 10.11 30 129803 2080 29820565
Neutrophilic dermatosis 14.75 10.11 10 129823 203 29822442
Portal fibrosis 14.73 10.11 13 129820 394 29822251
Injection site swelling 14.70 10.11 10 129823 8770 29813875
Amnesia 14.65 10.11 55 129778 24266 29798379
Peripheral motor neuropathy 14.61 10.11 26 129807 1633 29821012
Neutropenic sepsis 14.57 10.11 92 129741 11317 29811328
Conjunctivitis 14.56 10.11 71 129762 7929 29814716
Emotional distress 14.49 10.11 29 129804 15736 29806909
Drug intolerance 14.46 10.11 126 129707 45165 29777480
Escherichia bacteraemia 14.44 10.11 36 129797 2866 29819779
Immunodeficiency common variable 14.41 10.11 9 129824 158 29822487
Escherichia sepsis 14.36 10.11 44 129789 3950 29818695
Cold sweat 14.35 10.11 11 129822 9071 29813574
Blood immunoglobulin G decreased 14.33 10.11 19 129814 921 29821724
Faeces discoloured 14.29 10.11 24 129809 13922 29808723
Paradoxical drug reaction 14.28 10.11 34 129799 2628 29820017
Aspartate aminotransferase increased 14.27 10.11 368 129465 63054 29759591
Viral test positive 14.21 10.11 10 129823 216 29822429
Acute respiratory distress syndrome 14.19 10.11 160 129673 23312 29799333
Asterixis 14.13 10.11 22 129811 1237 29821408
Incorrect dose administered 14.12 10.11 80 129753 31606 29791039
Nightmare 14.09 10.11 19 129814 12057 29810588
Paranoia 14.08 10.11 14 129819 10174 29812471
Alcohol abuse 14.07 10.11 3 129830 5350 29817295
Differentiation syndrome 14.05 10.11 21 129812 1139 29821506
Incorrect route of product administration 14.04 10.11 17 129816 11298 29811347
Prescribed overdose 14.00 10.11 10 129823 8551 29814094
Fungal infection 14.00 10.11 104 129729 13496 29809149
Cholestatic liver injury 13.98 10.11 25 129808 1576 29821069
Electrocardiogram T wave peaked 13.96 10.11 14 129819 500 29822145
Steroid diabetes 13.84 10.11 22 129811 1259 29821386
Paraspinal abscess 13.83 10.11 7 129826 80 29822565
Postural tremor 13.79 10.11 11 129822 289 29822356
Bladder spasm 13.78 10.11 18 129815 860 29821785
Hypercalcaemia 13.70 10.11 97 129736 12398 29810247
Mucosal infection 13.60 10.11 10 129823 232 29822413
Poikiloderma 13.56 10.11 9 129824 176 29822469
Motion sickness 13.56 10.11 9 129824 176 29822469
Pulmonary physical examination abnormal 13.54 10.11 5 129828 24 29822621
Varicella 13.50 10.11 24 129809 1506 29821139
Skin bacterial infection 13.49 10.11 6 129827 50 29822595
Anger 13.49 10.11 17 129816 11103 29811542
Reactive gastropathy 13.48 10.11 9 129824 178 29822467
Peripheral sensory neuropathy 13.46 10.11 56 129777 5845 29816800
Systemic infection 13.45 10.11 16 129817 694 29821951
Respiratory tract infection 13.45 10.11 114 129719 15392 29807253
Angina pectoris 13.44 10.11 74 129759 29444 29793201
Pemphigoid 13.39 10.11 8 129825 7520 29815125
Encephalopathy 13.39 10.11 205 129628 32000 29790645
Hyperphosphataemia 13.38 10.11 30 129803 2229 29820416
Peripheral arterial occlusive disease 13.37 10.11 3 129830 5165 29817480
Disseminated intravascular coagulation 13.35 10.11 151 129682 22020 29800625
Subcapsular renal haematoma 13.34 10.11 12 129821 373 29822272
Musculoskeletal pain 13.32 10.11 79 129754 30861 29791784
Rash pruritic 13.26 10.11 153 129680 22419 29800226
Sinusitis bacterial 13.26 10.11 11 129822 306 29822339
Impaired work ability 13.22 10.11 4 129829 5639 29817006
Peritonitis bacterial 13.18 10.11 18 129815 11360 29811285
Pseudohyponatraemia 13.18 10.11 7 129826 89 29822556
Prostatitis 13.17 10.11 49 129784 4858 29817787
Polyglandular autoimmune syndrome type III 13.11 10.11 4 129829 9 29822636
Parvovirus infection 13.09 10.11 13 129820 459 29822186
Cardiogenic shock 13.07 10.11 34 129799 16827 29805818
Limb discomfort 13.02 10.11 12 129821 9038 29813607
Mental disorder 13.00 10.11 24 129809 13425 29809220
Hepatotoxicity 13.00 10.11 128 129705 18017 29804628
Distributive shock 12.98 10.11 15 129818 631 29822014
Respiratory syncytial virus infection 12.95 10.11 38 129795 3330 29819315
Brief psychotic disorder with marked stressors 12.93 10.11 8 129825 138 29822507
Interstitial lung disease 12.88 10.11 347 129486 59850 29762795
Gastroenteritis adenovirus 12.84 10.11 7 129826 94 29822551
Pulpitis dental 12.80 10.11 12 129821 394 29822251
Joint stiffness 12.78 10.11 13 129820 9348 29813297
Hypertensive emergency 12.77 10.11 17 129816 827 29821818
Sexual dysfunction 12.77 10.11 5 129828 5996 29816649
Immunosuppressant drug level decreased 12.76 10.11 21 129812 1238 29821407
Psychotic disorder 12.73 10.11 49 129784 21466 29801179
Mycobacterium fortuitum infection 12.73 10.11 9 129824 196 29822449
Haptoglobin decreased 12.67 10.11 14 129819 560 29822085
Adverse event 12.62 10.11 30 129803 15311 29807334
Mantle cell lymphoma refractory 12.59 10.11 7 129826 98 29822547
Renal papillary necrosis 12.58 10.11 8 129825 145 29822500
Blood bilirubin increased 12.57 10.11 226 129607 36410 29786235
Botulism 12.53 10.11 9 129824 201 29822444
Product storage error 12.53 10.11 6 129827 6385 29816260
Type 3 diabetes mellitus 12.49 10.11 5 129828 31 29822614
Ischaemic stroke 12.48 10.11 33 129800 16242 29806403
Mycobacterium abscessus infection 12.40 10.11 14 129819 574 29822071
Human ehrlichiosis 12.38 10.11 9 129824 205 29822440
Colitis 12.36 10.11 195 129638 30625 29792020
Nervousness 12.34 10.11 20 129813 11768 29810877
Fixed eruption 12.34 10.11 20 129813 1164 29821481
Lymphocytic infiltration 12.32 10.11 14 129819 578 29822067
Heart rate decreased 12.30 10.11 48 129785 20946 29801699
Cardiac failure chronic 12.29 10.11 5 129828 5858 29816787
Anal inflammation 12.26 10.11 11 129822 341 29822304
Blood bilirubin unconjugated increased 12.25 10.11 15 129818 671 29821974
Granuloma skin 12.24 10.11 10 129823 272 29822373
Bacterial sepsis 12.24 10.11 48 129785 4878 29817767
Asymptomatic COVID-19 12.23 10.11 5 129828 33 29822612
Ischaemic cardiomyopathy 12.21 10.11 6 129827 6291 29816354
Prothrombin level abnormal 12.17 10.11 7 129826 105 29822540
Acute lymphocytic leukaemia recurrent 12.14 10.11 32 129801 2635 29820010
Urinoma 12.12 10.11 9 129824 212 29822433
Skin candida 12.12 10.11 13 129820 503 29822142
Product complaint 12.09 10.11 5 129828 5801 29816844
Citrobacter infection 12.05 10.11 13 129820 506 29822139
Blood glucose decreased 12.00 10.11 24 129809 13029 29809616
High-grade B-cell lymphoma 11.99 10.11 8 129825 158 29822487
Babesiosis 11.97 10.11 6 129827 67 29822578
Pneumatosis intestinalis 11.97 10.11 32 129801 2658 29819987
Glomerulonephritis rapidly progressive 11.93 10.11 12 129821 430 29822215
Computerised tomogram thorax abnormal 11.87 10.11 15 129818 693 29821952
Clostridium test positive 11.84 10.11 27 129806 2029 29820616
Hyperpyrexia 11.81 10.11 31 129802 2546 29820099
Coombs direct test positive 11.79 10.11 10 129823 287 29822358
Chronic graft versus host disease 11.78 10.11 42 129791 4077 29818568
Biopsy liver abnormal 11.77 10.11 8 129825 163 29822482
Viral load increased 11.75 10.11 33 129800 2821 29819824
Gait inability 11.75 10.11 42 129791 18799 29803846
Retinal ischaemia 11.73 10.11 11 129822 361 29822284
Surgery 11.72 10.11 20 129813 11531 29811114
Bacterial infection 11.63 10.11 94 129739 12516 29810129
Trichophytic granuloma 11.60 10.11 6 129827 72 29822573
Respiratory depression 11.59 10.11 20 129813 11483 29811162
Septic embolus 11.59 10.11 19 129814 1116 29821529
Muscle spasticity 11.58 10.11 4 129829 5184 29817461
Campylobacter gastroenteritis 11.57 10.11 16 129817 808 29821837
Miosis 11.56 10.11 10 129823 7766 29814879
Irritability 11.50 10.11 56 129777 22994 29799651
Infective pulmonary exacerbation of cystic fibrosis 11.50 10.11 70 129763 8502 29814143
Coronary artery bypass 11.49 10.11 4 129829 5158 29817487
Haemoglobinaemia 11.48 10.11 8 129825 170 29822475
Nausea 11.47 10.11 1120 128713 295837 29526808
Carotid artery stenosis 11.46 10.11 3 129830 4651 29817994
Underdose 11.44 10.11 22 129811 12119 29810526
Cardiac valve vegetation 11.42 10.11 12 129821 453 29822192
Systemic candida 11.42 10.11 32 129801 2732 29819913
Tuberculosis of central nervous system 11.40 10.11 8 129825 172 29822473
Dementia 11.38 10.11 23 129810 12438 29810207
Transplant failure 11.36 10.11 30 129803 2474 29820171
C-reactive protein abnormal 11.35 10.11 5 129828 5588 29817057
Mixed liver injury 11.29 10.11 26 129807 1967 29820678
Urine protein/creatinine ratio increased 11.28 10.11 8 129825 175 29822470
Granulomatous rosacea 11.28 10.11 8 129825 175 29822470
Atypical mycobacterium test positive 11.27 10.11 3 129830 3 29822642
Fontanelle depressed 11.27 10.11 3 129830 3 29822642
Erythroblast count increased 11.27 10.11 3 129830 3 29822642
Alcaligenes infection 11.27 10.11 3 129830 3 29822642
Graft versus host disease in gastrointestinal tract 11.21 10.11 34 129799 3035 29819610
Hepatitis E 11.19 10.11 23 129810 1609 29821036
Hypersomnia 11.11 10.11 20 129813 11296 29811349
Mania 11.10 10.11 14 129819 9140 29813505
Myositis 11.05 10.11 80 129753 10297 29812348
Optic discs blurred 11.04 10.11 6 129827 80 29822565
Tendon discomfort 11.04 10.11 9 129824 244 29822401
Hypoaesthesia 10.99 10.11 167 129666 54063 29768582
Mastitis 10.97 10.11 8 129825 183 29822462
Visual impairment 10.95 10.11 82 129751 30356 29792289
Central nervous system infection 10.94 10.11 12 129821 476 29822169
Salivary hypersecretion 10.92 10.11 10 129823 7556 29815089
Akathisia 10.89 10.11 6 129827 5898 29816747
Cyclosporidium infection 10.87 10.11 4 129829 19 29822626
Metastases to lung 10.74 10.11 11 129822 7884 29814761
Limbal stem cell deficiency 10.70 10.11 4 129829 20 29822625
Culture urine positive 10.70 10.11 20 129813 1305 29821340
Lower respiratory tract infection fungal 10.68 10.11 13 129820 578 29822067
Respiratory syncytial virus test positive 10.65 10.11 9 129824 257 29822388
Brain compression 10.65 10.11 8 129825 192 29822453
Eschar 10.64 10.11 13 129820 580 29822065
T-cell prolymphocytic leukaemia 10.63 10.11 5 129828 48 29822597
Pain in jaw 10.63 10.11 23 129810 12133 29810512
Internal haemorrhage 10.61 10.11 3 129830 4419 29818226
No reaction on previous exposure to drug 10.61 10.11 6 129827 87 29822558
Abdominal distension 10.60 10.11 137 129696 45572 29777073
Myelosuppression 10.60 10.11 61 129772 7261 29815384
Hospitalisation 10.59 10.11 132 129701 44187 29778458
Brain herniation 10.58 10.11 38 129795 3702 29818943
Amyotrophy 10.57 10.11 12 129821 495 29822150
Dysarthria 10.56 10.11 83 129750 30407 29792238
Unmasking of previously unidentified disease 10.56 10.11 13 129820 585 29822060
Heart rate increased 10.55 10.11 112 129721 38609 29784036
Granulocytopenia 10.54 10.11 7 129826 6219 29816426
Graft versus host disease in liver 10.54 10.11 17 129816 985 29821660
Drug abuser 10.53 10.11 3 129830 4398 29818247
Polyarteritis nodosa 10.50 10.11 9 129824 262 29822383
Blood cholesterol increased 10.47 10.11 38 129795 16932 29805713
Obesity 10.46 10.11 13 129820 8542 29814103
Middle insomnia 10.46 10.11 6 129827 5767 29816878
Bacterial pyelonephritis 10.44 10.11 9 129824 264 29822381
Acinetobacter infection 10.44 10.11 17 129816 993 29821652
Pyelonephritis acute 10.40 10.11 22 129811 1571 29821074
Discomfort 10.34 10.11 30 129803 14326 29808319
Lactic acidosis 10.34 10.11 86 129747 31127 29791518
Neoplasm malignant 10.27 10.11 41 129792 17773 29804872
Flavobacterium infection 10.26 10.11 6 129827 93 29822552
Heart transplant rejection 10.23 10.11 19 129814 1234 29821411
Skin exfoliation 10.21 10.11 149 129684 23023 29799622
Liver injury 10.15 10.11 90 129743 12310 29810335
Pericarditis 10.14 10.11 68 129765 8538 29814107
Euphoric mood 10.12 10.11 3 129830 4287 29818358
Peripheral T-cell lymphoma unspecified recurrent 10.12 10.11 5 129828 54 29822591

Pharmacologic Action:

SourceCodeDescription
ATC J01EA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Trimethoprim and derivatives
ATC J01EE01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J04AM08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
FDA MoA N0000000191 Dihydrofolate Reductase Inhibitors
FDA EPC N0000175489 Dihydrofolate Reductase Inhibitor Antibacterial
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D065687 Cytochrome P-450 CYP2C8 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
FDA MoA N0000187061 Organic Cation Transporter 2 Inhibitors
FDA MoA N0000187062 Cytochrome P450 2C8 Inhibitors
CHEBI has role CHEBI:35498 diuretics
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:50683 7,8-dihydrofolate reductase inhibitors
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute otitis media indication 3110003
Shigellosis indication 36188001
Klebsiella cystitis indication 60867007
Urinary tract infectious disease indication 68566005
Blepharoconjunctivitis indication 68659002 DOID:2456
Bacterial conjunctivitis indication 128350005 DOID:9700
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Pneumocystosis jiroveci pneumonia indication 415125002 DOID:11339
Acute exacerbation of chronic bronchitis indication 425748003
Morganella Morganii Urinary Tract Infection indication
Staphylococcus Aureus Urinary Tract Infection indication
Haemophilus Influenzae Acute Otitis Media indication
Pneumocystis Carinii Pneumonia Prevention indication
Haemophilus Influenzae Chronic Bronchitis indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Typhoid fever off-label use 4834000 DOID:13258
Infection of skin AND/OR subcutaneous tissue off-label use 19824006
Pertussis off-label use 27836007
Granuloma inguinale off-label use 28867007 DOID:9113
Nocardiosis off-label use 29227009 DOID:2312
Listeria meningitis off-label use 31568009 DOID:11572
Sinusitis off-label use 36971009
Whipple's disease off-label use 41545003 DOID:8476
Bacterial pneumonia off-label use 53084003 DOID:874
Paracoccidioidomycosis off-label use 59925007 DOID:12662
Cholera off-label use 63650001 DOID:1498
Brucellosis off-label use 75702008 DOID:11077
Paratyphoid fever off-label use 85904008 DOID:3055
Chlamydial infection off-label use 105629000
Infection of bone off-label use 111253001
Meningococcus carrier off-label use 170486006
Lymphogranuloma venereum off-label use 186946009 DOID:13819
Chancroid off-label use 266143009 DOID:13778
Diverticulitis of gastrointestinal tract off-label use 271366000
Bacterial endocarditis off-label use 301183007
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Toxoplasmosis Prevention off-label use
Postexposure Plague Prophylaxis off-label use
Chronic Bacterial Prostatitis off-label use
Diabetic Foot Infection off-label use
Third trimester pregnancy contraindication 41587001
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Folic acid deficiency contraindication 190633005
Disease of liver contraindication 235856003 DOID:409
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Pseudomembranous enterocolitis contraindication 397683000
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.01 Basic
pKa2 0.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Dihydrofolate reductase Enzyme Ki 8 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.25 CHEMBL
Dihydrofolate reductase Enzyme INHIBITOR IC50 5.57 CHEMBL CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 7.99 CHEMBL
Dihydrofolate reductase Enzyme Ki 8.92 CHEMBL
Dihydrofolate reductase Enzyme Ki 6.88 CHEMBL
Dihydrofolate reductase Enzyme IC50 6.35 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 6.92 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 8.14 CHEMBL
Dihydrofolate reductase Enzyme IC50 4.92 CHEMBL
Dihydrofolate reductase Enzyme IC50 8.66 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Unclassified IC50 5.40 CHEMBL
Dihydrofolate reductase Enzyme Ki 6.30 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.84 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.62 CHEMBL
Dihydrofolate reductase Enzyme IC50 6.35 CHEMBL
Dihydrofolate reductase Unclassified Ki 8.89 CHEMBL
Dihydrofolate reductase type 1 Unclassified IC50 6.30 CHEMBL
Dihydrofolate reductase Enzyme IC50 6.72 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 8 WOMBAT-PK
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 6 WOMBAT-PK
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 6.92 WOMBAT-PK
Dihydrofolate reductase Enzyme Ki 6.82 CHEMBL
Dihydrofolate reductase Unclassified Ki 8.08 CHEMBL

External reference:

IDSource
4017735 VUID
N0000146103 NUI
D00145 KEGG_DRUG
60834-30-2 SECONDARY_CAS_RN
4017735 VANDF
4019528 VANDF
C0041041 UMLSCUI
CHEBI:45924 CHEBI
TOP PDB_CHEM_ID
CHEMBL22 ChEMBL_ID
CHEMBL1201080 ChEMBL_ID
CHEMBL2110367 ChEMBL_ID
D014295 MESH_DESCRIPTOR_UI
1047 INN_ID
DB00440 DRUGBANK_ID
AN164J8Y0X UNII
5578 PUBCHEM_CID
10931 IUPHAR_LIGAND_ID
10829 RXNORM
3055 MMSL
5633 MMSL
5634 MMSL
d00123 MMSL
002873 NDDF
008281 NDDF
32792001 SNOMEDCT_US
387179001 SNOMEDCT_US
412323009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Polytrim HUMAN PRESCRIPTION DRUG LABEL 2 0023-7824 SOLUTION/ DROPS 1 mg OPHTHALMIC NDA 19 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0121-0853 SUSPENSION 40 mg ORAL NDA 28 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 0121-0854 SUSPENSION 40 mg ORAL NDA 28 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0121-4793 SUSPENSION 40 mg ORAL ANDA 28 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0440-2406 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5180 SUSPENSION 40 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5181 SUSPENSION 40 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0615-0170 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0615-8121 TABLET 160 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9503 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 22 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 22 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 22 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 22 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0904-2725 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-053 TABLET 160 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-092 TABLET 160 mg ORAL ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-525 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-926 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-940 TABLET 160 mg ORAL ANDA 27 sections
Sulfamethoxazole and Trimethoprim DS HUMAN PRESCRIPTION DRUG LABEL 2 12634-177 TABLET 160 mg ORAL ANDA 21 sections
SULFAMETHOXAZOLE and TRIMETHOPRIM HUMAN PRESCRIPTION DRUG LABEL 2 12634-779 SUSPENSION 40 mg ORAL ANDA 21 sections
Primsol HUMAN PRESCRIPTION DRUG LABEL 1 13551-501 SOLUTION 50 mg ORAL NDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 16590-210 TABLET 160 mg ORAL ANDA 29 sections
Polymyxin B Sulfate and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 16590-233 SOLUTION 1 mg OPHTHALMIC ANDA 17 sections
POLYMYXIN B SULFATE AND TRIMETHOPRIM HUMAN PRESCRIPTION DRUG LABEL 2 17478-703 SOLUTION 1 mg OPHTHALMIC ANDA 19 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 17856-0007 SUSPENSION 40 mg ORAL NDA 21 sections
Sulfamethoxazole and Trimethoprim Human Prescription Drug Label 2 17856-0496 SUSPENSION 40 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 17856-0823 SUSPENSION 40 mg ORAL ANDA 20 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 17856-5181 SUSPENSION 40 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 21695-125 TABLET 160 mg ORAL ANDA 13 sections