trimethoprim 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antimicrobials, dihydrofolate reductase (DHFR) inhibitors, trimethoprim analogues 2755 738-70-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trimethoprim
  • trimethoprim sulfate
  • trimethoprim hydrochloride
  • trimethioprim
  • trimetoprim
  • trimopan
  • trimethoprim HCl
A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
  • Molecular weight: 290.32
  • Formula: C14H18N4O3
  • CLOGP: 1.08
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 105.51
  • ALOGS: -2.67
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 1.37 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 70 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 15.75 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.50 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.50 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.555 Moderate 0.65
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.023 Moderate 0.65
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 13.521 10^-6 cm/s Moderate 0.65
dh-clint Dog hepatocyte intrinsic clearance 1.486 uL/min/10^6 cells Moderate 0.65
dppb Dog plasma protein binding (% unbound) 71.570 % Moderate 0.65
fcs-ppb Fetal calf serum protein binding (% unbound) 81.540 % Moderate 0.65
herg hERG pIC50 4.374 pIC50 Moderate 0.65
hh-clint Human hepatocyte intrinsic clearance 1.445 uL/min/10^6 cells Moderate 0.65
hlm-clint Human liver microsomal intrinsic clearance 3.155 uL/min/mg protein Moderate 0.65
hppb Human plasma protein binding (% unbound) 55.330 % Moderate 0.65
kinase-safety-class ACVR2B,AXL,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,MAP3K21,MAPK7,PDK2,PDK4,PIK3CD,PRKDC 13
kinase-selectivity-class ACVR2B,AXL,MAP3K21,PIK3CB,PIK3CD 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 1.884 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.679 Moderate 0.65
mh-clint Mouse hepatocyte intrinsic clearance 8.511 Moderate 0.65
mppb Mouse plasma protein binding (% unbound) 71.100 Moderate 0.65
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 5.754 Moderate 0.65
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 77.090 % Moderate 0.65
rat-kpuu-brain Rat brain Kpuu 0.061 % High 1
rh-clint Rat hepatocyte intrinsic clearance 6.252 uL/min/10^6 cells Moderate 0.65
rh-fuinc Rat hepatocyte fraction unbound in incubation 92.810 % Moderate 0.65
rppb Rat plasma protein binding (% unbound) 63.530 % Moderate 0.65
solubility-dd Solubility at pH 7.4 in DMSO 883.080 uM Moderate 0.65

Approvals:

DateAgencyCompanyOrphan
July 30, 1973 FDA MUTUAL PHARM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Swelling face 327.42 10.54 340 62584 81012 90484511
Swollen tongue 235.03 10.54 219 62705 45737 90519786
Angioedema 190.32 10.54 230 62694 64646 90500877
Soft tissue disorder 186.27 10.54 80 62844 4210 90561313
Acute kidney injury 154.22 10.54 531 62393 319856 90245667
Liver function test abnormal 131.09 10.54 169 62755 50676 90514847
Dysphonia 118.35 10.54 180 62744 62904 90502619
Drug ineffective 114.17 10.54 535 62389 1383763 89181760
Pre-engraftment immune reaction 107.58 10.54 27 62897 241 90565282
Product dose omission issue 104.56 10.54 36 62888 291651 90273872
Pneumonia viral 94.68 10.54 65 62859 8758 90556765
Hyperkalaemia 94.22 10.54 165 62759 64799 90500724
Pyrexia 90.52 10.54 774 62150 659711 89905812
Pancytopenia 85.70 10.54 229 62695 120034 90445489
Leukopenia 83.42 10.54 203 62721 100507 90465016
Injection site pain 81.00 10.54 12 62912 173687 90391836
Lip swelling 80.80 10.54 116 62808 38494 90527029
Stevens-Johnson syndrome 79.43 10.54 100 62824 29276 90536247
Encephalitis viral 78.00 10.54 34 62890 1855 90563668
Drug ineffective for unapproved indication 76.34 10.54 153 62771 66491 90499032
Hyponatraemia 73.66 10.54 232 62692 133306 90432217
Rash maculo-papular 70.07 10.54 112 62812 40821 90524702
Fatigue 68.60 10.54 495 62429 1153528 89411995
Synovial fluid analysis 67.91 10.54 35 62889 2783 90562740
Tenosynovitis stenosans 67.26 10.54 39 62885 3914 90561609
Abdominal discomfort 66.83 10.54 145 62779 477183 90088340
Allergy to chemicals 66.44 10.54 38 62886 3716 90561807
Cytomegalovirus infection 64.79 10.54 86 62838 26516 90539007
Macular degeneration 63.78 10.54 103 62821 37867 90527656
Human herpesvirus 6 infection 61.44 10.54 35 62889 3397 90562126
Alopecia 60.89 10.54 161 62763 494910 90070613
Scleritis 59.77 10.54 40 62884 5168 90560355
International normalised ratio increased 59.50 10.54 113 62811 47203 90518320
Oral candidiasis 59.31 10.54 96 62828 35359 90530164
Completed suicide 57.21 10.54 15 62909 145043 90420480
Ejection fraction decreased 53.65 10.54 78 62846 26175 90539348
Conjunctivitis 52.63 10.54 78 62846 26628 90538895
Vaginal discharge 50.63 10.54 65 62859 19399 90546124
Inappropriate schedule of product administration 49.54 10.54 21 62903 149912 90415611
Photophobia 49.11 10.54 67 62857 21202 90544321
Psoriasis 48.33 10.54 21 62903 147733 90417790
Pleuritic pain 48.04 10.54 47 62877 10414 90555109
Tenderness 48.03 10.54 75 62849 26793 90538730
Abdominal pain 48.02 10.54 452 62472 395269 90170254
Kidney transplant rejection 47.95 10.54 34 62890 4823 90560700
Blood pressure increased 47.78 10.54 40 62884 197177 90368346
Intentional overdose 47.34 10.54 5 62919 93829 90471694
Crepitations 46.81 10.54 43 62881 8809 90556714
Rectal haemorrhage 46.76 10.54 145 62779 82599 90482924
Hypophagia 46.64 10.54 87 62837 35850 90529673
Anaemia 45.84 10.54 409 62515 352393 90213130
Deep vein thrombosis 44.08 10.54 152 62772 91468 90474055
Injection site reaction 43.76 10.54 6 62918 92074 90473449
Death 43.14 10.54 167 62757 456384 90109139
Product use issue 43.07 10.54 104 62820 329815 90235708
Toxic epidermal necrolysis 42.53 10.54 79 62845 32449 90533074
Chronic sinusitis 41.94 10.54 66 62858 23736 90541787
Bone marrow failure 41.81 10.54 78 62846 32143 90533380
Mouth swelling 41.15 10.54 33 62891 5629 90559894
Cushingoid 40.97 10.54 43 62881 10352 90555171
Female genital tract fistula 40.82 10.54 56 62868 17812 90547711
Fall 40.72 10.54 184 62740 481626 90083897
Pain 40.50 10.54 470 62454 995871 89569652
Fear of eating 40.11 10.54 14 62910 418 90565105
COVID-19 39.98 10.54 35 62889 168808 90396715
Systemic lupus erythematosus 39.82 10.54 124 62800 361772 90203751
Proctitis 39.75 10.54 51 62873 15208 90550315
Drug reaction with eosinophilia and systemic symptoms 39.54 10.54 90 62834 42668 90522855
Vaginal flatulence 39.00 10.54 46 62878 12592 90552931
Renal failure 38.80 10.54 187 62737 130820 90434703
Oral pain 38.58 10.54 76 62848 32607 90532916
Superinfection 38.38 10.54 25 62899 3087 90562436
Drug interaction 35.63 10.54 320 62604 276133 90289390
Injection site erythema 35.53 10.54 12 62912 98490 90467033
Blood creatinine increased 35.45 10.54 152 62772 101234 90464289
Paraesthesia oral 35.43 10.54 72 62852 31587 90533936
Bacterial sepsis 34.15 10.54 28 62896 4927 90560596
Atelectasis 34.09 10.54 61 62863 24348 90541175
Genital ulceration 33.82 10.54 16 62908 1057 90564466
Deformity 33.81 10.54 42 62882 12128 90553395
Maternal exposure timing unspecified 33.75 10.54 58 62866 22425 90543098
Off label use 33.65 10.54 551 62373 1101701 89463822
Radiculopathy 33.56 10.54 52 62872 18453 90547070
Synovial disorder 33.52 10.54 23 62901 3095 90562428
Suicide attempt 33.37 10.54 6 62918 75393 90490130
Arthralgia 32.86 10.54 364 62560 778158 89787365
Urosepsis 32.17 10.54 55 62869 21177 90544346
Thrombocytopenia 31.88 10.54 251 62673 208474 90357049
Synovial cyst 31.76 10.54 40 62884 11712 90553811
Nasopharyngitis 31.73 10.54 160 62764 406944 90158579
Migraine 31.73 10.54 52 62872 190340 90375183
Agranulocytosis 31.61 10.54 73 62851 34929 90530594
Pemphigus 31.21 10.54 119 62805 326745 90238778
Potentiating drug interaction 30.91 10.54 28 62896 5634 90559889
Antinuclear antibody positive 30.80 10.54 35 62889 9206 90556317
Pulmonary toxicity 30.77 10.54 39 62885 11492 90554031
Cholecystitis chronic 30.71 10.54 36 62888 9790 90555733
Procedural pain 30.60 10.54 70 62854 33290 90532233
Neutropenic sepsis 30.19 10.54 49 62875 18081 90547442
Platelet count decreased 30.00 10.54 180 62744 136789 90428734
Liver function test increased 29.47 10.54 11 62913 84844 90480679
Influenza 29.34 10.54 32 62892 139232 90426291
Genital pain 29.22 10.54 13 62911 745 90564778
Meningoencephalitis herpetic 29.17 10.54 16 62908 1443 90564080
Deafness transitory 29.16 10.54 18 62906 2025 90563498
Feeling jittery 29.01 10.54 44 62880 15327 90550196
Arthropathy 28.50 10.54 144 62780 366098 90199425
Flank pain 28.09 10.54 49 62875 19173 90546350
Complications of transplanted kidney 28.07 10.54 20 62904 2858 90562665
Drug abuse 28.06 10.54 11 62913 82336 90483187
Hepatic enzyme increased 27.97 10.54 142 62782 360594 90204929
Transplant rejection 27.67 10.54 39 62885 12719 90552804
Pneumocystis jirovecii pneumonia 27.64 10.54 52 62872 21564 90543959
HIV infection 27.56 10.54 11 62913 480 90565043
Excessive eye blinking 27.30 10.54 15 62909 1357 90564166
No adverse event 26.85 10.54 7 62917 67975 90497548
Documented hypersensitivity to administered product 26.74 10.54 12 62912 702 90564821
Maternal exposure during pregnancy 26.65 10.54 144 62780 359919 90205604
Confusional state 26.28 10.54 395 62529 385810 90179713
Ureteric obstruction 26.08 10.54 17 62907 2101 90563422
Parkinsonian rest tremor 26.04 10.54 8 62916 158 90565365
Blood pressure fluctuation 25.91 10.54 3 62921 52410 90513113
Injection site bruising 25.85 10.54 3 62921 52304 90513219
Infection 25.68 10.54 373 62551 361721 90203802
Tenosynovitis 25.12 10.54 40 62884 14527 90550996
Trimethylaminuria 24.89 10.54 8 62916 184 90565339
Discomfort 24.83 10.54 102 62822 274233 90291290
Depression 24.65 10.54 116 62808 300485 90265038
Urinary tract infection 24.58 10.54 322 62602 305310 90260213
Herpes zoster 24.44 10.54 130 62794 94514 90471009
Memory impairment 24.30 10.54 64 62860 197180 90368343
Liver disorder 23.83 10.54 155 62769 121114 90444409
Bacterial test positive 23.80 10.54 24 62900 5515 90560008
Wrong technique in product usage process 23.67 10.54 10 62914 71561 90493962
Muscle twitching 23.56 10.54 52 62872 24150 90541373
Contraindicated product administered 23.16 10.54 129 62795 320010 90245513
Blood pressure systolic increased 23.06 10.54 6 62918 58339 90507184
Pregnancy with injectable contraceptive 22.99 10.54 7 62917 134 90565389
Vulvovaginal candidiasis 22.70 10.54 20 62904 3880 90561643
Pain in extremity 22.57 10.54 202 62722 450327 90115196
Psoriatic arthropathy 22.52 10.54 82 62842 228253 90337270
Bone density decreased 22.52 10.54 42 62882 17303 90548220
Red blood cell sedimentation rate decreased 22.36 10.54 12 62912 1036 90564487
Blindness cortical 22.28 10.54 10 62914 585 90564938
Haemoglobin decreased 22.16 10.54 190 62734 161766 90403757
Injection site swelling 22.09 10.54 7 62917 59832 90505691
Intentional product use issue 21.99 10.54 77 62847 216815 90348708
Toxicity to various agents 21.91 10.54 114 62810 287732 90277791
Seizure 21.91 10.54 181 62743 152448 90413075
Erythrosis 21.79 10.54 6 62918 79 90565444
Ocular hyperaemia 21.72 10.54 62 62862 33736 90531787
Pericarditis 21.70 10.54 105 62819 270046 90295477
Clostridial infection 21.61 10.54 21 62903 4615 90560908
Weight increased 21.10 10.54 187 62737 417740 90147783
Rash pruritic 20.60 10.54 112 62812 82102 90483421
Product quality issue 20.58 10.54 15 62909 79310 90486213
Hepatitis fulminant 20.54 10.54 19 62905 3926 90561597
Hepatic enzyme decreased 20.53 10.54 11 62913 947 90564576
Impaired work ability 20.50 10.54 43 62881 19283 90546240
Glossodynia 20.47 10.54 135 62789 321644 90243879
Pregnancy 20.15 10.54 91 62833 61956 90503567
Body mass index decreased 20.14 10.54 9 62915 521 90565002
Treatment failure 20.10 10.54 126 62798 303802 90261721
Acquired immunodeficiency syndrome 19.95 10.54 6 62918 110 90565413
Joint effusion 19.92 10.54 43 62881 19667 90545856
Multiple organ dysfunction syndrome 19.83 10.54 97 62827 68239 90497284
Renal tubular disorder 19.79 10.54 17 62907 3190 90562333
Pulmonary embolism 19.79 10.54 157 62767 130663 90434860
Foaming at mouth 19.53 10.54 12 62912 1338 90564185
Anti-cyclic citrullinated peptide antibody positive 19.51 10.54 91 62833 236342 90329181
Effusion 19.36 10.54 14 62910 2048 90563475
Jaundice 19.31 10.54 58 62866 32459 90533064
Loss of personal independence in daily activities 19.29 10.54 41 62883 136064 90429459
Eye pain 19.29 10.54 71 62853 44097 90521426
Dehydration 19.18 10.54 213 62711 194234 90371289
Blood sodium decreased 19.07 10.54 52 62872 27561 90537962
Leukoencephalopathy 18.92 10.54 20 62904 4853 90560670
Fluid retention 18.82 10.54 20 62904 88071 90477452
Malaise 18.75 10.54 536 62388 585450 89980073
Libido disorder 18.66 10.54 5 62919 59 90565464
Device expulsion 18.65 10.54 3 62921 40883 90524640
Hydronephrosis 18.62 10.54 32 62892 12370 90553153
Dermatitis exfoliative 18.51 10.54 21 62903 5515 90560008
Physical assault 18.50 10.54 10 62914 876 90564647
Gastrointestinal pain 18.27 10.54 30 62894 11176 90554347
Urine output decreased 18.25 10.54 32 62892 12571 90552952
Lethargy 17.88 10.54 89 62835 63050 90502473
Aplasia pure red cell 17.87 10.54 20 62904 5174 90560349
White blood cell count decreased 17.85 10.54 186 62738 166923 90398600
Hospitalisation 17.81 10.54 39 62885 128061 90437462
Cholelithiasis 17.80 10.54 78 62846 52428 90513095
Condition aggravated 17.66 10.54 299 62625 595246 89970277
Mucosal inflammation 17.59 10.54 83 62841 57542 90507981
Immune reconstitution inflammatory syndrome 17.57 10.54 23 62901 6996 90558527
Accidental exposure to product 17.44 10.54 4 62920 42362 90523161
Hypovolaemic shock 17.37 10.54 23 62901 7071 90558452
Renal tubular necrosis 17.36 10.54 34 62890 14521 90551002
Medication error 17.12 10.54 109 62815 84543 90480980
Pseudomembranous colitis 17.06 10.54 17 62907 3851 90561672
Cogwheel rigidity 16.89 10.54 13 62911 2089 90563434
Cystitis noninfective 16.89 10.54 11 62913 1358 90564165
Soft tissue swelling 16.82 10.54 11 62913 1367 90564156
Septic shock 16.79 10.54 108 62816 84052 90481471
Bronchopulmonary aspergillosis 16.58 10.54 29 62895 11369 90554154
Functional gastrointestinal disorder 16.58 10.54 19 62905 5043 90560480
Blood culture positive 16.55 10.54 19 62905 5053 90560470
Blepharospasm 16.42 10.54 9 62915 55436 90510087
Mental status changes 16.40 10.54 68 62856 44611 90520912
Tarsal tunnel syndrome 16.36 10.54 8 62916 569 90564954
Chemotherapeutic drug level increased 16.29 10.54 6 62918 210 90565313
Blood alkaline phosphatase increased 15.98 10.54 71 62853 48008 90517515
Purpura senile 15.87 10.54 8 62916 607 90564916
Febrile neutropenia 15.86 10.54 174 62750 158175 90407348
Cataract 15.82 10.54 16 62908 72076 90493447
Inappropriate antidiuretic hormone secretion 15.80 10.54 39 62885 19466 90546057
Palmar erythema 15.75 10.54 12 62912 1899 90563624
Breast cancer 15.53 10.54 9 62915 53752 90511771
Taste disorder 15.50 10.54 12 62912 61534 90503989
Rheumatoid arthritis 15.46 10.54 169 62755 362445 90203078
Vomiting 15.28 10.54 681 62243 787612 89777911
Rash erythematous 15.18 10.54 87 62837 65017 90500506
Meningitis aseptic 15.13 10.54 21 62903 6752 90558771
Subdural haemorrhage 15.01 10.54 15 62909 3408 90562115
Abnormal loss of weight 15.01 10.54 21 62903 6802 90558721
Tubulointerstitial nephritis 14.86 10.54 45 62879 25298 90540225
Rhinorrhoea 14.82 10.54 24 62900 88292 90477231
Grip strength decreased 14.76 10.54 26 62898 92550 90472973
Stress 14.73 10.54 21 62903 81374 90484149
Dry skin 14.71 10.54 24 62900 88049 90477474
Overdose 14.66 10.54 58 62866 157651 90407872
Back injury 14.66 10.54 7 62917 46615 90518908
Hiccups 14.66 10.54 14 62910 3012 90562511
Pseudomonas infection 14.54 10.54 32 62892 14833 90550690
Febrile bone marrow aplasia 14.46 10.54 25 62899 9713 90555810
Lung transplant rejection 14.42 10.54 9 62915 1032 90564491
Immunosuppressant drug level increased 14.38 10.54 17 62907 4663 90560860
Antinuclear antibody 14.31 10.54 7 62917 498 90565025
Wound 14.23 10.54 138 62786 302842 90262681
Hepatic failure 14.22 10.54 60 62864 39668 90525855
Foetal exposure during pregnancy 14.22 10.54 6 62918 42969 90522554
Dialysis 14.17 10.54 27 62897 11302 90554221
Oliguria 14.13 10.54 26 62898 10598 90554925
Fibromyalgia 14.02 10.54 211 62713 206058 90359465
HIV wasting syndrome 13.81 10.54 3 62921 13 90565510
Hepatic cytolysis 13.75 10.54 50 62874 30866 90534657
Osteoporosis 13.74 10.54 29 62895 96502 90469021
Left ventricular dysfunction 13.69 10.54 31 62893 14638 90550885
Nasal congestion 13.69 10.54 23 62901 83391 90482132
Incorrect dose administered 13.67 10.54 21 62903 78909 90486614
Therapeutic response decreased 13.59 10.54 26 62898 89703 90475820
Muscle haemorrhage 13.47 10.54 14 62910 3332 90562191
Circulatory collapse 13.47 10.54 43 62881 24861 90540662
Haemorrhoids 13.45 10.54 45 62879 26657 90538866
Tonsillar hypertrophy 13.44 10.54 9 62915 1163 90564360
Sepsis 13.43 10.54 187 62737 179627 90385896
Vestibular disorder 13.37 10.54 10 62914 1539 90563984
Thrombotic microangiopathy 13.31 10.54 32 62892 15711 90549812
Angiodermatitis 13.18 10.54 5 62919 190 90565333
Genital burning sensation 13.15 10.54 6 62918 365 90565158
Limb discomfort 13.11 10.54 5 62919 38055 90527468
Onychomadesis 12.87 10.54 8 62916 45990 90519533
Axillary vein thrombosis 12.86 10.54 6 62918 384 90565139
Immunodeficiency 12.83 10.54 7 62917 43227 90522296
Cushing's syndrome 12.79 10.54 7 62917 629 90564894
Neoplasm malignant 12.78 10.54 52 62872 33828 90531695
Onychomycosis 12.72 10.54 5 62919 37371 90528152
Cytomegalovirus test positive 12.65 10.54 14 62910 3577 90561946
Nail infection 12.65 10.54 12 62912 2560 90562963
Pleural effusion 12.60 10.54 126 62798 111865 90453658
Altered visual depth perception 12.49 10.54 6 62918 410 90565113
Lung disorder 12.49 10.54 159 62765 149724 90415799
Areflexia 12.45 10.54 14 62910 3639 90561884
Acute respiratory distress syndrome 12.43 10.54 46 62878 28640 90536883
Disseminated intravascular coagulation 12.40 10.54 38 62886 21500 90544023
Dermatitis allergic 12.33 10.54 33 62891 17294 90548229
Herpes simplex viraemia 12.30 10.54 6 62918 424 90565099
Epilepsy 12.29 10.54 24 62900 82182 90483341
Alanine aminotransferase increased 12.29 10.54 131 62793 118207 90447316
Surgery 12.29 10.54 8 62916 44879 90520644
Unevaluable event 12.23 10.54 12 62912 54836 90510687
Lip ulceration 12.19 10.54 11 62913 2201 90563322
Citrobacter infection 12.16 10.54 7 62917 693 90564830
Coeliac disease 12.15 10.54 8 62916 44602 90520921
Vaginal ulceration 12.02 10.54 6 62918 446 90565077
Rheumatoid nodule 12.00 10.54 36 62888 20130 90545393
Graft ischaemia 11.98 10.54 4 62920 104 90565419
Frequent bowel movements 11.94 10.54 74 62850 56861 90508662
Plasma cell myeloma 11.88 10.54 58 62866 40770 90524753
Finger deformity 11.87 10.54 4 62920 32893 90532630
Rash macular 11.84 10.54 47 62877 30233 90535290
Lung infiltration 11.79 10.54 30 62894 15252 90550271
Liver transplant 11.76 10.54 11 62913 2306 90563217
Pulmonary fibrosis 11.69 10.54 37 62887 107466 90458057
Aspartate aminotransferase increased 11.67 10.54 116 62808 102821 90462702
Refusal of treatment by patient 11.65 10.54 17 62907 5721 90559802
Throat irritation 11.63 10.54 10 62914 48685 90516838
Intentional self-injury 11.62 10.54 3 62921 29331 90536192
Red blood cell count decreased 11.51 10.54 63 62861 46288 90519235
Pustule 11.49 10.54 12 62912 2871 90562652
Asthma 11.49 10.54 110 62814 242050 90323473
Tremor 11.32 10.54 159 62765 153014 90412509
Lymphocele 11.21 10.54 7 62917 804 90564719
Infusion related reaction 11.15 10.54 213 62711 416567 90148956
Acne 11.14 10.54 3 62921 28504 90537019
Haemodialysis 11.13 10.54 21 62903 8726 90556797
Campylobacter gastroenteritis 11.06 10.54 7 62917 822 90564701
Perinephric collection 11.05 10.54 4 62920 133 90565390
Graft versus host disease 10.92 10.54 20 62904 8124 90557399
Neutropenia 10.92 10.54 218 62706 224686 90340837
Arthritis 10.92 10.54 170 62754 167145 90398378
Hypersensitivity 10.91 10.54 402 62522 454275 90111248
Resorption bone increased 10.82 10.54 8 62916 1211 90564312
Haematopoietic neoplasm 10.79 10.54 3 62921 41 90565482
Abscess rupture 10.72 10.54 5 62919 320 90565203
Therapy cessation 10.63 10.54 6 62918 36355 90529168
Colitis 10.60 10.54 84 62840 69858 90495665
Presyncope 10.59 10.54 47 62877 31758 90533765

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 234.20 11.56 160 40193 638175 41942807
Drug ineffective 205.55 11.56 178 40175 630019 41950963
Pyrexia 165.96 11.56 774 39579 393268 42187714
Hyperkalaemia 163.80 11.56 282 40071 80176 42500806
Acute kidney injury 120.40 11.56 673 39680 366664 42214318
Neutropenia 106.07 11.56 421 39932 199010 42381972
Blood creatinine increased 92.65 11.56 271 40082 109732 42471250
Death 88.87 11.56 197 40156 470988 42109994
Stevens-Johnson syndrome 83.48 11.56 104 40249 22074 42558908
Pancytopenia 83.32 11.56 273 40080 117470 42463512
Immune reconstitution inflammatory syndrome 82.70 11.56 72 40281 10071 42570911
Product use in unapproved indication 78.92 11.56 38 40315 184418 42396564
Cytomegalovirus infection 78.86 11.56 123 40230 32183 42548799
Product dose omission issue 64.20 11.56 33 40320 154332 42426650
Drug abuse 64.10 11.56 11 40342 104760 42476222
Completed suicide 61.56 11.56 9 40344 96456 42484526
Anal inflammation 59.86 11.56 33 40320 2196 42578786
SARS-CoV-2 test negative 58.15 11.56 30 40323 1745 42579237
Transplant rejection 58.12 11.56 68 40285 13520 42567462
Proctalgia 57.12 11.56 50 40303 7043 42573939
Thrombocytopenia 53.26 11.56 335 40018 189944 42391038
Inappropriate schedule of product administration 52.61 11.56 13 40340 95889 42485093
Kidney transplant rejection 50.33 11.56 51 40302 8632 42572350
Cellulitis enterococcal 49.51 11.56 13 40340 100 42580882
Product use issue 49.34 11.56 7 40346 76744 42504238
Fatigue 46.79 11.56 233 40120 435408 42145574
Haemodialysis 46.66 11.56 53 40300 10207 42570775
Hepatitis 44.49 11.56 87 40266 27213 42553769
Pre-engraftment immune reaction 43.74 11.56 13 40340 164 42580818
Body temperature increased 43.52 11.56 73 40280 20285 42560697
Alanine aminotransferase increased 43.19 11.56 182 40171 88224 42492758
Aspartate aminotransferase increased 42.59 11.56 165 40188 76998 42503984
Renal tubular necrosis 42.19 11.56 68 40285 18286 42562696
Leukopenia 41.39 11.56 160 40193 74586 42506396
Blood bilirubin increased 40.32 11.56 109 40244 42143 42538839
Agranulocytosis 39.88 11.56 89 40264 30523 42550459
Osteoporotic fracture 39.56 11.56 22 40331 1489 42579493
Encephalitis viral 39.33 11.56 22 40331 1506 42579476
Blood urea increased 39.03 11.56 92 40261 32701 42548281
Pneumocystis jirovecii pneumonia 38.33 11.56 78 40275 25103 42555879
Weight increased 38.04 11.56 28 40325 107955 42473027
Blood lactate dehydrogenase increased 37.60 11.56 79 40274 26002 42554980
Haemorrhoids 37.47 11.56 62 40291 17035 42563947
Chills 37.24 11.56 182 40171 93884 42487098
Respiratory tract infection bacterial 34.79 11.56 22 40331 1887 42579095
Hospitalisation 33.81 11.56 14 40339 74316 42506666
Lymphocyte count decreased 33.07 11.56 78 40275 27731 42553251
Intestinal intraepithelial lymphocytes increased 32.89 11.56 11 40342 208 42580774
Cholestasis 32.56 11.56 86 40267 32793 42548189
Blood alkaline phosphatase increased 31.38 11.56 86 40267 33511 42547471
Injection site pain 31.37 11.56 8 40345 57790 42523192
Liver function test abnormal 31.34 11.56 84 40269 32307 42548675
Dialysis 31.16 11.56 47 40306 11939 42569043
Toxicity to various agents 31.03 11.56 112 40241 229024 42351958
Renal failure 30.70 11.56 237 40116 143489 42437493
Cryptitis 29.83 11.56 11 40342 280 42580702
Respiratory tract infection viral 29.43 11.56 25 40328 3381 42577601
Aplasia pure red cell 29.22 11.56 35 40318 7131 42573851
Platelet count decreased 28.76 11.56 227 40126 138354 42442628
Accident 28.57 11.56 33 40320 6470 42574512
Hepatic cytolysis 28.42 11.56 72 40281 26772 42554210
Microvillous inclusion disease 27.95 11.56 10 40343 233 42580749
Kaposi's sarcoma 27.68 11.56 14 40339 781 42580201
Blood antidiuretic hormone increased 27.62 11.56 7 40346 46 42580936
Total lung capacity abnormal 27.41 11.56 27 40326 4416 42576566
Plasma cell myeloma 27.27 11.56 103 40250 47475 42533507
Liver transplant rejection 27.12 11.56 21 40332 2492 42578490
Jaundice 26.97 11.56 83 40270 34506 42546476
Drug intolerance 26.87 11.56 22 40331 80402 42500580
HIV infection 26.78 11.56 17 40336 1468 42579514
Toxic skin eruption 26.42 11.56 47 40306 13683 42567299
Bone marrow failure 26.35 11.56 80 40273 33013 42547969
SARS-CoV-2 antibody test positive 26.33 11.56 11 40342 393 42580589
Intentional overdose 26.29 11.56 8 40345 51448 42529534
Cerebrovascular accident 26.24 11.56 32 40321 97128 42483854
Intentional product use issue 26.11 11.56 18 40335 71815 42509167
Rash 26.05 11.56 387 39966 276567 42304415
Fall 25.92 11.56 124 40229 234396 42346586
Acute febrile neutrophilic dermatosis 25.40 11.56 18 40335 1866 42579116
Blood potassium increased 25.39 11.56 55 40298 18481 42562501
Treatment failure 25.11 11.56 14 40339 62610 42518372
Human herpesvirus 6 infection 24.88 11.56 20 40333 2505 42578477
Foetal exposure during pregnancy 24.82 11.56 7 40346 47304 42533678
Rectal abscess 24.55 11.56 17 40336 1698 42579284
Hepatosplenomegaly 24.54 11.56 26 40327 4634 42576348
Nasopharyngitis 24.49 11.56 26 40327 83970 42497012
Neurological symptom 24.31 11.56 38 40315 9953 42571029
Acquired immunodeficiency syndrome 23.91 11.56 11 40342 497 42580485
Drug ineffective for unapproved indication 23.90 11.56 7 40346 46156 42534826
Rash maculo-papular 23.87 11.56 84 40269 37419 42543563
Probiotic therapy 23.74 11.56 8 40345 155 42580827
Lymphocele 23.72 11.56 16 40337 1531 42579451
Renal papillary necrosis 23.60 11.56 8 40345 158 42580824
Gamma-glutamyltransferase increased 23.52 11.56 76 40277 32421 42548561
Hepatitis cholestatic 23.40 11.56 37 40316 9787 42571195
Vomiting 23.16 11.56 394 39959 289329 42291653
Culture urine positive 22.58 11.56 15 40338 1400 42579582
Febrile bone marrow aplasia 22.42 11.56 37 40316 10144 42570838
Mental status changes 22.36 11.56 89 40264 42026 42538956
Apoptosis 22.29 11.56 11 40342 582 42580400
Hepatomegaly 22.24 11.56 40 40313 11745 42569237
Dermatitis exfoliative 22.11 11.56 30 40323 6917 42574065
Therapeutic product effect decreased 22.06 11.56 5 40348 39145 42541837
Graft versus host disease 22.04 11.56 42 40311 12883 42568099
Aspergillus infection 21.70 11.56 47 40306 15790 42565192
Pneumonia cytomegaloviral 21.69 11.56 23 40330 4103 42576879
Neuritis 21.55 11.56 28 40325 6192 42574790
Pulmonary alveolar haemorrhage 21.49 11.56 45 40308 14771 42566211
Pulmonary vasculitis 21.39 11.56 28 40325 6238 42574744
Haemoglobin decreased 21.22 11.56 205 40148 132266 42448716
Wrong technique in product usage process 21.12 11.56 7 40346 42628 42538354
Leukaemia recurrent 20.95 11.56 16 40337 1860 42579122
Lung infiltration 20.89 11.56 43 40310 13946 42567036
Drug reaction with eosinophilia and systemic symptoms 20.82 11.56 87 40266 41988 42538994
Intentional product misuse 20.59 11.56 17 40336 61883 42519099
Proteus infection 20.42 11.56 14 40339 1376 42579606
Biopsy liver abnormal 20.38 11.56 7 40346 144 42580838
Myositis 20.24 11.56 44 40309 14822 42566160
Motion sickness 20.16 11.56 8 40345 250 42580732
Rash morbilliform 19.82 11.56 22 40331 4131 42576851
Psoriasis 19.29 11.56 11 40342 48593 42532389
Dehydration 19.20 11.56 212 40141 141555 42439427
Escherichia urinary tract infection 18.93 11.56 22 40331 4341 42576641
White blood cell count decreased 18.76 11.56 173 40180 110223 42470759
Serum sickness 18.55 11.56 16 40337 2209 42578773
Ureteric obstruction 18.44 11.56 13 40340 1336 42579646
Biopsy 18.00 11.56 8 40345 333 42580649
Vena cava injury 17.94 11.56 8 40345 336 42580646
Genital pain 17.88 11.56 11 40342 899 42580083
Phlebitis 17.69 11.56 21 40332 4237 42576745
Suicide attempt 17.50 11.56 11 40342 46089 42534893
Eosinophilic granulomatosis with polyangiitis 17.18 11.56 30 40323 8608 42572374
Forced expiratory volume decreased 17.16 11.56 28 40325 7602 42573380
Chronic lymphocytic leukaemia 17.14 11.56 22 40331 4807 42576175
Viral test positive 17.14 11.56 7 40346 236 42580746
Vasculitis 17.09 11.56 47 40306 18347 42562635
Sedation 16.96 11.56 4 40349 30471 42550511
Renal tubular disorder 16.85 11.56 22 40331 4887 42576095
Joint swelling 16.73 11.56 24 40329 67998 42512984
Blood culture positive 16.35 11.56 22 40331 5031 42575951
Rheumatoid arthritis 16.28 11.56 10 40343 42430 42538552
Stress 16.17 11.56 11 40342 44201 42536781
Culture stool positive 16.13 11.56 7 40346 275 42580707
Erythema infectiosum 16.05 11.56 6 40347 159 42580823
Arthritis 16.02 11.56 10 40343 42055 42538927
Liver transplant 15.95 11.56 16 40337 2675 42578307
Oesophageal candidiasis 15.95 11.56 23 40330 5612 42575370
HIV wasting syndrome 15.79 11.56 5 40348 79 42580903
Genital ulceration 15.57 11.56 10 40343 881 42580101
Neutrophil count decreased 15.48 11.56 108 40245 63307 42517675
Complications of transplanted kidney 15.38 11.56 22 40331 5328 42575654
Lymphopenia 15.21 11.56 50 40303 21513 42559469
Orbital haemorrhage 15.21 11.56 4 40349 31 42580951
Febrile neutropenia 14.97 11.56 253 40100 185450 42395532
Clonal haematopoiesis 14.95 11.56 6 40347 193 42580789
International normalised ratio increased 14.82 11.56 87 40266 48081 42532901
Hepatitis A antibody positive 14.58 11.56 4 40349 37 42580945
Photosensitivity reaction 14.42 11.56 35 40318 12667 42568315
Enterovirus infection 14.38 11.56 11 40342 1282 42579700
Wound evisceration 14.24 11.56 5 40348 110 42580872
Meningoencephalitis herpetic 14.22 11.56 10 40343 1024 42579958
COVID-19 14.18 11.56 59 40294 115889 42465093
Rectal prolapse 14.14 11.56 8 40345 560 42580422
Blood calcium decreased 14.13 11.56 32 40321 11076 42569906
Light chain analysis decreased 14.12 11.56 4 40349 42 42580940
Radiation inflammation 14.10 11.56 10 40343 1038 42579944
Renal tubular acidosis 13.87 11.56 15 40338 2735 42578247
Arthralgia 13.79 11.56 126 40227 205112 42375870
Cytomegalovirus test 13.72 11.56 4 40349 47 42580935
C-reactive protein increased 13.65 11.56 105 40248 63455 42517527
Hepatic steatosis 13.61 11.56 48 40305 21400 42559582
Lymphadenopathy 13.51 11.56 65 40288 33300 42547682
Hepatitis B antibody positive 13.49 11.56 4 40349 50 42580932
Heart rate decreased 13.48 11.56 9 40344 36523 42544459
Cytomegalovirus chorioretinitis 13.31 11.56 19 40334 4592 42576390
Erosive duodenitis 13.19 11.56 12 40341 1777 42579205
Tubulointerstitial nephritis 13.16 11.56 62 40291 31486 42549496
Toxic epidermal necrolysis 12.99 11.56 55 40298 26695 42554287
Hepatitis C virus test 12.82 11.56 4 40349 60 42580922
Haematocrit decreased 12.71 11.56 66 40287 34842 42546140
Laryngeal pain 12.70 11.56 14 40339 2608 42578374
Refusal of treatment by patient 12.70 11.56 20 40333 5271 42575711
Renal cyst haemorrhage 12.70 11.56 8 40345 682 42580300
Mycobacterium avium complex infection 12.70 11.56 15 40338 3012 42577970
Lymphocytic infiltration 12.66 11.56 9 40344 937 42580045
Somnolence 12.61 11.56 80 40273 141025 42439957
CD4 lymphocytes increased 12.55 11.56 5 40348 158 42580824
Cystic lymphangioma 12.53 11.56 3 40350 15 42580967
Stent removal 12.53 11.56 3 40350 15 42580967
Suprapubic pain 12.52 11.56 7 40346 479 42580503
Granulomatous rosacea 12.49 11.56 5 40348 160 42580822
Acute graft versus host disease in intestine 12.48 11.56 17 40336 3934 42577048
Idiopathic pneumonia syndrome 12.45 11.56 7 40346 484 42580498
Intraductal papillary mucinous neoplasm 12.45 11.56 7 40346 484 42580498
Parvovirus infection 12.44 11.56 7 40346 485 42580497
Blood pressure increased 12.38 11.56 52 40301 101876 42479106
Peripheral swelling 12.27 11.56 44 40309 90226 42490756
Therapeutic product effect prolonged 12.25 11.56 6 40347 312 42580670
Malignant neoplasm progression 12.14 11.56 57 40296 108343 42472639
Complications of transplant surgery 12.13 11.56 7 40346 509 42580473
Abdominal wall haemorrhage 12.10 11.56 7 40346 511 42580471
Lung disorder 11.92 11.56 82 40271 47841 42533141
Product prescribing error 11.74 11.56 5 40348 26107 42554875
Lung neoplasm 11.64 11.56 18 40335 4670 42576312

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Swelling face 298.19 10.45 364 85932 91957 110411046
Hyperkalaemia 239.14 10.45 401 85895 135395 110367608
Acute kidney injury 232.42 10.45 1046 85250 634384 109868619
Drug ineffective 197.18 10.45 575 85721 1519965 108983038
Swollen tongue 186.80 10.45 233 86063 60129 110442874
Angioedema 169.55 10.45 288 86008 98212 110404791
Pyrexia 156.39 10.45 1216 85080 897049 109605954
Pre-engraftment immune reaction 148.99 10.45 40 86256 419 110502584
Off label use 128.23 10.45 670 85626 1499515 109003488
Stevens-Johnson syndrome 123.20 10.45 167 86129 46734 110456269
Encephalitis viral 120.86 10.45 55 86241 2952 110500051
Product dose omission issue 120.64 10.45 50 86246 321732 110181271
Completed suicide 111.70 10.45 26 86270 242355 110260648
Pancytopenia 105.01 10.45 381 85915 209232 110293771
Death 103.23 10.45 247 86049 698622 109804381
Injection site pain 100.04 10.45 11 86285 177911 110325092
Liver function test abnormal 96.15 10.45 184 86112 68766 110434237
Blood creatinine increased 91.23 10.45 332 85964 182557 110320446
Dysphonia 89.59 10.45 189 86107 75740 110427263
Fatigue 87.17 10.45 574 85722 1215384 109287619
Soft tissue disorder 86.35 10.45 46 86250 3478 110499525
Cytomegalovirus infection 84.32 10.45 152 86144 54292 110448711
Inappropriate schedule of product administration 82.39 10.45 28 86268 203609 110299394
Human herpesvirus 6 infection 80.57 10.45 55 86241 6526 110496477
Drug abuse 79.83 10.45 20 86276 177391 110325612
Kidney transplant rejection 74.29 10.45 67 86229 11920 110491083
Immune reconstitution inflammatory syndrome 72.89 10.45 76 86220 16150 110486853
Lip swelling 70.38 10.45 135 86161 50532 110452471
Allergy to chemicals 66.60 10.45 38 86258 3287 110499716
Tenosynovitis stenosans 66.38 10.45 39 86257 3564 110499439
Synovial fluid analysis 65.70 10.45 35 86261 2646 110500357
Intentional overdose 65.60 10.45 12 86284 132489 110370514
International normalised ratio increased 64.75 10.45 181 86115 86591 110416412
Leukopenia 63.43 10.45 257 86039 148534 110354469
Transplant rejection 62.28 10.45 86 86210 24481 110478522
Anal inflammation 59.52 10.45 32 86264 2464 110500539
Hyponatraemia 59.19 10.45 330 85966 217323 110285680
Fall 58.54 10.45 257 86039 603225 109899778
Haemodialysis 57.38 10.45 70 86226 17649 110485354
Rash maculo-papular 56.54 10.45 156 86140 74066 110428937
Scleritis 56.37 10.45 41 86255 5379 110497624
SARS-CoV-2 test negative 55.29 10.45 29 86267 2124 110500879
Drug reaction with eosinophilia and systemic symptoms 54.28 10.45 164 86132 81931 110421072
Thrombocytopenia 54.26 10.45 461 85835 348424 110154579
Pneumonia viral 53.27 10.45 54 86242 11103 110491900
Blood pressure increased 51.56 10.45 76 86220 258297 110244706
Toxicity to various agents 50.72 10.45 198 86098 480357 110022646
Haemorrhoids 50.71 10.45 96 86200 35576 110467427
Product use issue 50.13 10.45 105 86191 311590 110191413
Renal failure 49.18 10.45 324 85972 226250 110276753
Proctalgia 49.05 10.45 56 86240 13166 110489837
Genital ulceration 49.01 10.45 26 86270 1949 110501054
Psoriasis 48.91 10.45 24 86272 139969 110363034
Genital pain 48.18 10.45 23 86273 1377 110501626
Neutropenia 48.11 10.45 475 85821 374145 110128858
Wrong technique in product usage process 47.60 10.45 6 86290 87342 110415661
Fear of eating 46.65 10.45 17 86279 511 110502492
Vaginal discharge 45.86 10.45 63 86233 17845 110485158
Conjunctivitis 45.66 10.45 89 86207 33703 110469300
Crepitations 42.09 10.45 47 86249 10788 110492215
Renal tubular necrosis 42.07 10.45 81 86215 30394 110472609
Photophobia 41.24 10.45 73 86223 25698 110477305
Deafness transitory 40.82 10.45 19 86277 1074 110501929
Nasopharyngitis 40.64 10.45 164 86132 394197 110108806
Suicide attempt 40.47 10.45 15 86281 103379 110399624
Ureteric obstruction 40.45 10.45 27 86269 3087 110499916
Oral candidiasis 40.14 10.45 100 86196 44660 110458343
Arthralgia 39.64 10.45 403 85893 779229 109723774
Macular degeneration 39.47 10.45 65 86231 21594 110481409
Blood urea increased 39.40 10.45 113 86183 54844 110448159
Meningoencephalitis herpetic 39.07 10.45 24 86272 2378 110500625
Alopecia 38.65 10.45 150 86146 364603 110138400
Dialysis 38.65 10.45 61 86235 19558 110483445
Female genital tract fistula 37.70 10.45 55 86241 16464 110486539
Hypophagia 37.52 10.45 108 86188 52518 110450485
Platelet count decreased 37.13 10.45 307 85989 230136 110272867
Influenza 36.48 10.45 47 86249 169054 110333949
Injection site reaction 36.45 10.45 12 86284 89058 110413945
Blood pressure systolic increased 36.10 10.45 10 86286 82981 110420022
Jaundice 36.07 10.45 115 86181 59121 110443882
Cushingoid 35.88 10.45 45 86251 11667 110491336
Mouth swelling 35.85 10.45 36 86260 7318 110495685
Tenderness 35.56 10.45 74 86222 29363 110473640
Ejection fraction decreased 35.27 10.45 90 86206 40790 110462213
Agranulocytosis 35.00 10.45 117 86179 61643 110441360
Pneumocystis jirovecii pneumonia 34.73 10.45 92 86204 42643 110460360
Weight increased 34.69 10.45 189 86107 419455 110083548
Injection site erythema 34.67 10.45 15 86281 94161 110408842
Urosepsis 34.61 10.45 75 86221 30600 110472403
Vaginal flatulence 34.59 10.45 45 86251 12099 110490904
Toxic epidermal necrolysis 34.42 10.45 110 86186 56617 110446386
Paraesthesia oral 34.26 10.45 79 86217 33592 110469411
Bone marrow failure 34.04 10.45 111 86185 57737 110445266
Febrile bone marrow aplasia 33.99 10.45 54 86242 17411 110485592
Respiratory tract infection bacterial 33.94 10.45 22 86274 2394 110500609
Abdominal discomfort 33.89 10.45 175 86121 393683 110109320
Proctitis 33.86 10.45 53 86243 16874 110486129
Intestinal intraepithelial lymphocytes increased 33.86 10.45 11 86285 232 110502771
COVID-19 33.46 10.45 90 86206 244970 110258033
Haemoglobin decreased 32.69 10.45 317 85979 248410 110254593
Deformity 32.67 10.45 40 86256 10120 110492883
Chronic sinusitis 32.60 10.45 65 86231 25019 110477984
Atelectasis 31.85 10.45 81 86215 36631 110466372
Synovial disorder 31.85 10.45 23 86273 2984 110500019
Rash 31.83 10.45 852 85444 820112 109682891
Drug ineffective for unapproved indication 31.39 10.45 161 86135 102677 110400326
Radiculopathy 31.24 10.45 55 86241 19281 110483722
Liver function test increased 31.20 10.45 15 86281 88533 110414470
Nasal congestion 31.20 10.45 19 86277 98263 110404740
Total lung capacity abnormal 31.16 10.45 27 86269 4556 110498447
Blood alkaline phosphatase increased 30.59 10.45 123 86173 70812 110432191
Maternal exposure timing unspecified 30.43 10.45 57 86239 20956 110482047
Intentional product use issue 30.24 10.45 96 86200 247810 110255193
Pleuritic pain 30.17 10.45 49 86247 16091 110486912
Neurological symptom 30.02 10.45 48 86248 15560 110487443
Oral pain 29.81 10.45 80 86216 37364 110465639
Blood lactate dehydrogenase increased 29.71 10.45 89 86207 44245 110458758
Rectal haemorrhage 29.49 10.45 177 86119 119656 110383347
Gastrointestinal pain 29.29 10.45 41 86255 11819 110491184
Migraine 29.14 10.45 56 86240 171596 110331407
Cellulitis enterococcal 28.96 10.45 7 86289 46 110502957
Synovial cyst 28.95 10.45 40 86256 11390 110491613
Cryptitis 28.69 10.45 11 86285 382 110502621
Microvillous inclusion disease 28.49 10.45 10 86286 269 110502734
Blood potassium increased 28.48 10.45 73 86223 33176 110469827
Rhinorrhoea 28.43 10.45 23 86273 102643 110400360
Hospitalisation 28.33 10.45 42 86254 142451 110360552
Blood culture positive 28.32 10.45 35 86261 8941 110494062
Feeling jittery 27.94 10.45 45 86251 14677 110488326
Deep vein thrombosis 27.92 10.45 196 86100 139691 110363312
Memory impairment 27.90 10.45 71 86225 196873 110306130
Antinuclear antibody positive 27.73 10.45 35 86261 9133 110493870
Superinfection 27.71 10.45 28 86268 5735 110497268
Alanine aminotransferase increased 27.57 10.45 241 86055 183532 110319471
Acute febrile neutrophilic dermatosis 27.50 10.45 26 86270 4910 110498093
Stress 27.47 10.45 25 86271 105323 110397680
Product quality issue 27.38 10.45 13 86283 77286 110425717
Clostridial infection 27.38 10.45 29 86267 6273 110496730
Liver transplant 27.17 10.45 25 86271 4564 110498439
Injection site pruritus 26.80 10.45 4 86292 51254 110451749
Complications of transplanted kidney 26.73 10.45 31 86265 7411 110495592
Liver transplant rejection 26.47 10.45 23 86273 3895 110499108
Therapeutic response decreased 26.25 10.45 22 86274 96477 110406526
Dermatitis exfoliative 26.21 10.45 38 86258 11309 110491694
Injection site swelling 25.86 10.45 8 86288 61782 110441221
Documented hypersensitivity to administered product 25.55 10.45 14 86282 1120 110501883
Body temperature increased 25.31 10.45 97 86199 54616 110448387
Mental status changes 25.23 10.45 122 86174 76000 110427003
Apoptosis 25.21 10.45 12 86284 714 110502289
Bacterial test positive 25.00 10.45 31 86265 7946 110495057
Tubulointerstitial nephritis 24.92 10.45 96 86200 54188 110448815
Pain 24.82 10.45 562 85734 954393 109548610
Liver disorder 24.80 10.45 193 86103 142050 110360953
Cardiogenic shock 24.77 10.45 7 86289 57331 110445672
Pulmonary vasculitis 24.70 10.45 28 86268 6532 110496471
Probiotic therapy 24.52 10.45 8 86288 171 110502832
Culture urine positive 24.34 10.45 24 86272 4772 110498231
Rash pruritic 24.22 10.45 145 86151 97924 110405079
Abdominal pain 24.22 10.45 547 85749 512442 109990561
Lung infiltration 24.20 10.45 57 86239 24571 110478432
Blood bilirubin increased 23.93 10.45 120 86176 75852 110427151
Intentional product misuse 23.77 10.45 42 86254 132862 110370141
Accidental exposure to product 23.76 10.45 5 86291 50003 110453000
Malaise 23.70 10.45 689 85607 671130 109831873
Vulvovaginal candidiasis 23.65 10.45 20 86276 3265 110499738
Aspartate aminotransferase increased 23.60 10.45 209 86087 159727 110343276
Pregnancy with injectable contraceptive 23.59 10.45 7 86289 108 110502895
Overdose 23.58 10.45 98 86198 233696 110269307
Hepatosplenomegaly 23.49 10.45 28 86268 6891 110496112
Pulmonary embolism 23.29 10.45 263 86033 214211 110288792
Flank pain 23.24 10.45 54 86242 23076 110479927
Product use in unapproved indication 23.21 10.45 230 86066 447147 110055856
Plasma cell myeloma 23.16 10.45 104 86192 62832 110440171
Trimethylaminuria 23.09 10.45 8 86288 207 110502796
Procedural pain 22.53 10.45 70 86226 35495 110467508
Pulmonary alveolar haemorrhage 22.43 10.45 49 86247 20101 110482902
Serum sickness 22.28 10.45 22 86274 4384 110498619
Neuritis 21.99 10.45 28 86268 7371 110495632
Renal tubular disorder 21.90 10.45 28 86268 7401 110495602
Chronic obstructive pulmonary disease 21.87 10.45 32 86264 109126 110393877
Blood antidiuretic hormone increased 21.68 10.45 6 86290 71 110502932
Taste disorder 21.66 10.45 12 86284 65375 110437628
Excessive eye blinking 21.41 10.45 15 86281 1855 110501148
Urinary tract infection 21.14 10.45 365 85931 325917 110177086
No adverse event 21.13 10.45 16 86280 73823 110429180
Neutropenic sepsis 20.86 10.45 62 86234 30684 110472319
Arthropathy 20.83 10.45 135 86161 287387 110215616
Refusal of treatment by patient 20.78 10.45 31 86265 9463 110493540
Cholecystitis chronic 20.77 10.45 31 86265 9469 110493534
Hepatic enzyme increased 20.63 10.45 156 86140 320736 110182267
Rectal abscess 20.63 10.45 17 86279 2679 110500324
Renal papillary necrosis 20.57 10.45 9 86287 440 110502563
Fluid retention 20.55 10.45 26 86270 94281 110408722
Leukaemia recurrent 20.39 10.45 18 86278 3113 110499890
Breast cancer 20.16 10.45 3 86293 38539 110464464
Depression 20.06 10.45 155 86141 317180 110185823
Bronchopulmonary aspergillosis 20.06 10.45 60 86236 29803 110473200
Vomiting 20.01 10.45 885 85411 909790 109593213
Blepharospasm 19.77 10.45 9 86287 54842 110448161
Tenosynovitis 19.74 10.45 41 86255 16242 110486761
Febrile neutropenia 19.68 10.45 352 85944 316415 110186588
Aspergillus infection 19.66 10.45 54 86242 25562 110477441
Psoriatic arthropathy 19.51 10.45 83 86213 196678 110306325
Blood sodium decreased 19.45 10.45 70 86226 38249 110464754
Cataract 19.40 10.45 20 86276 79465 110423538
Hepatomegaly 19.37 10.45 48 86248 21366 110481637
Mucosal inflammation 19.36 10.45 135 86161 96006 110406997
Contraindicated product administered 19.32 10.45 114 86182 248153 110254850
Vena cava injury 19.25 10.45 8 86288 344 110502659
Condition aggravated 19.20 10.45 432 85864 734404 109768599
Toxic skin eruption 19.16 10.45 56 86240 27459 110475544
Hepatitis 19.05 10.45 128 86168 89926 110413077
Thrombotic microangiopathy 19.05 10.45 58 86238 29091 110473912
Rash morbilliform 18.91 10.45 27 86269 7924 110495079
Hepatic enzyme decreased 18.87 10.45 11 86285 991 110502012
Accident 18.80 10.45 32 86264 10920 110492083
Erythema multiforme 18.77 10.45 47 86249 21050 110481953
Pseudomonas infection 18.74 10.45 56 86240 27797 110475206
Hepatitis cholestatic 18.74 10.45 42 86254 17524 110485479
Respiratory tract infection viral 18.67 10.45 23 86273 5855 110497148
Cytomegalovirus test 18.57 10.45 5 86291 53 110502950
Confusional state 18.57 10.45 488 85808 468192 110034811
Pregnancy 18.50 10.45 84 86212 50983 110452020
Red blood cell sedimentation rate decreased 18.38 10.45 12 86284 1322 110501681
Back injury 18.34 10.45 7 86289 47392 110455611
Cholestasis 18.30 10.45 99 86197 64419 110438584
Parkinsonian rest tremor 18.26 10.45 8 86288 392 110502611
Dehydration 18.22 10.45 313 85983 279198 110223805
Hypersensitivity 18.19 10.45 428 85868 403570 110099433
Pain in extremity 18.18 10.45 269 86027 486849 110016154
Systemic lupus erythematosus 18.13 10.45 120 86176 254218 110248785
SARS-CoV-2 antibody test positive 17.98 10.45 8 86288 407 110502596
Body mass index decreased 17.95 10.45 10 86286 826 110502177
Graft versus host disease 17.91 10.45 43 86253 18763 110484240
Bone density decreased 17.84 10.45 39 86257 16003 110487000
Aplasia pure red cell 17.80 10.45 29 86267 9549 110493454
Colour blindness acquired 17.70 10.45 6 86290 145 110502858
Sedation 17.62 10.45 17 86279 69666 110433337
Lymphopenia 17.59 10.45 70 86226 40100 110462903
Dry skin 17.51 10.45 36 86260 107617 110395386
Hepatitis fulminant 17.40 10.45 27 86269 8533 110494470
Pulmonary toxicity 17.36 10.45 41 86255 17705 110485298
Meningitis aseptic 17.15 10.45 29 86267 9841 110493162
Rash erythematous 17.12 10.45 116 86180 81716 110421287
Biliary sepsis 17.06 10.45 13 86283 1830 110501173
Biopsy liver abnormal 17.04 10.45 8 86288 461 110502542
HIV wasting syndrome 17.04 10.45 5 86291 74 110502929
Culture stool positive 17.03 10.45 9 86287 669 110502334
Vasculitis 16.92 10.45 64 86232 35809 110467194
Chills 16.91 10.45 225 86071 190355 110312648
Lymphocele 16.89 10.45 13 86283 1858 110501145
Drug dependence 16.83 10.45 9 86287 50011 110452992
Treatment failure 16.78 10.45 137 86159 277097 110225906
Eosinophilic granulomatosis with polyangiitis 16.75 10.45 30 86266 10656 110492347
Therapy cessation 16.74 10.45 7 86289 44850 110458153
Rash macular 16.61 10.45 67 86229 38619 110464384
White blood cell count decreased 16.47 10.45 261 86035 229129 110273874
Seizure 16.39 10.45 253 86043 220932 110282071
Hydronephrosis 16.30 10.45 44 86252 20621 110482382
HIV infection 16.21 10.45 11 86285 1292 110501711
Clostridium difficile infection 16.17 10.45 82 86214 52047 110450956
Abdominal wall haemorrhage 16.15 10.45 9 86287 744 110502259
Potentiating drug interaction 16.14 10.45 31 86265 11612 110491391
Orbital haemorrhage 16.09 10.45 4 86292 30 110502973
Infection 16.08 10.45 383 85913 361817 110141186
Joint effusion 15.98 10.45 44 86252 20861 110482142
Candida infection 15.95 10.45 77 86219 47932 110455071
Asthma 15.93 10.45 122 86174 250169 110252834
Myositis 15.93 10.45 57 86239 31059 110471944
Complications of transplant surgery 15.86 10.45 9 86287 770 110502233
Limb discomfort 15.86 10.45 6 86290 40848 110462155
Radiation inflammation 15.86 10.45 10 86286 1038 110501965
Tarsal tunnel syndrome 15.85 10.45 8 86288 541 110502462
Acquired immunodeficiency syndrome 15.83 10.45 7 86289 351 110502652
Pericarditis 15.81 10.45 103 86193 219011 110283992
Coeliac disease 15.70 10.45 7 86289 43180 110459823
Food poisoning 15.69 10.45 22 86274 6350 110496653
Onychomadesis 15.69 10.45 8 86288 45655 110457348
Osteonecrosis of jaw 15.64 10.45 9 86287 48008 110454995
Erythrosis 15.36 10.45 6 86290 219 110502784
Granulomatous rosacea 15.34 10.45 6 86290 220 110502783
Chronic lymphocytic leukaemia 15.29 10.45 21 86275 5947 110497056
Nodule 15.22 10.45 58 86238 32573 110470430
Blindness cortical 15.13 10.45 10 86286 1125 110501878
Erythema infectiosum 15.09 10.45 6 86290 230 110502773
Purpura senile 14.99 10.45 8 86288 607 110502396
Anaphylactic shock 14.97 10.45 11 86285 51535 110451468
Heart rate decreased 14.93 10.45 26 86270 82730 110420273
Perinephric collection 14.87 10.45 7 86289 406 110502597
Viral test positive 14.86 10.45 9 86287 869 110502134
Device expulsion 14.86 10.45 3 86293 30888 110472115
Blood bilirubin unconjugated increased 14.77 10.45 10 86286 1171 110501832
Haemoglobin increased 14.75 10.45 26 86270 9121 110493882
Bacterial sepsis 14.74 10.45 28 86268 10398 110492605
Enterococcal infection 14.71 10.45 42 86254 20324 110482679
Foaming at mouth 14.68 10.45 13 86283 2257 110500746
Erosive duodenitis 14.58 10.45 13 86283 2278 110500725
Eosinophilia 14.52 10.45 86 86210 57850 110445153
Autoimmune haemolytic anaemia 14.48 10.45 28 86268 10539 110492464
Onychomycosis 14.40 10.45 6 86290 38525 110464478
Effusion 14.37 10.45 14 86282 2743 110500260
Finger deformity 14.37 10.45 4 86292 33088 110469915
Palmar erythema 14.35 10.45 13 86283 2325 110500678
Antinuclear antibody 14.33 10.45 7 86289 441 110502562
Renal tubular acidosis 14.26 10.45 18 86278 4697 110498306
Pseudomembranous colitis 14.18 10.45 21 86275 6370 110496633
Wound evisceration 14.12 10.45 5 86291 138 110502865
Hepatic failure 14.12 10.45 97 86199 68642 110434361
Cytomegalovirus test positive 14.03 10.45 22 86274 7014 110495989
Haematocrit decreased 14.00 10.45 94 86202 66023 110436980
Blood pressure fluctuation 13.97 10.45 23 86273 74801 110428202
Anti-cyclic citrullinated peptide antibody positive 13.92 10.45 84 86212 181900 110321103
Vaginal ulceration 13.79 10.45 6 86290 289 110502714
Ocular hyperaemia 13.77 10.45 64 86232 39222 110463781
Intentional self-injury 13.71 10.45 6 86290 37423 110465580
Medication error 13.69 10.45 134 86162 105232 110397771
Forced expiratory volume decreased 13.50 10.45 31 86265 13145 110489858
Renal cyst haemorrhage 13.40 10.45 8 86288 753 110502250
Chemotherapeutic drug level increased 13.32 10.45 7 86289 515 110502488
Prurigo 13.23 10.45 10 86286 1390 110501613
Hepatitis C virus test 13.23 10.45 4 86292 66 110502937
Acute graft versus host disease in intestine 13.19 10.45 19 86277 5620 110497383
Surgery 13.07 10.45 8 86288 41275 110461728
Cough 13.02 10.45 268 86028 461373 110041630
Drug interaction 13.00 10.45 495 85801 499688 110003315
Lung disorder 12.98 10.45 205 86091 179842 110323161
Acne 12.89 10.45 5 86291 33515 110469488
Grip strength decreased 12.88 10.45 27 86269 80147 110422856
Incorrect dose administered 12.72 10.45 40 86256 103601 110399402
Autonomic neuropathy 12.60 10.45 12 86284 2288 110500715
Sleep apnoea syndrome 12.59 10.45 8 86288 40439 110462564
Culture positive 12.57 10.45 9 86287 1152 110501851
Osteoporotic fracture 12.51 10.45 18 86278 5319 110497684
Inappropriate antidiuretic hormone secretion 12.50 10.45 56 86240 33795 110469208
Angiodermatitis 12.47 10.45 5 86291 196 110502807
Prostatitis 12.46 10.45 17 86279 4784 110498219
Suicidal ideation 12.44 10.45 35 86261 93902 110409101
Eye pruritus 12.42 10.45 5 86291 32770 110470233
Lung transplant rejection 12.37 10.45 11 86285 1920 110501083
Eye pain 12.32 10.45 74 86222 50025 110452978
Unevaluable event 12.22 10.45 17 86279 59210 110443793
Muscle twitching 12.19 10.45 51 86245 29884 110473119
Petechiae 12.18 10.45 43 86253 23274 110479729
Functional gastrointestinal disorder 12.18 10.45 19 86277 6030 110496973
Discomfort 12.14 10.45 108 86188 214599 110288404
Cushing's syndrome 11.93 10.45 8 86288 922 110502081
Lymphocytic infiltration 11.93 10.45 11 86285 2014 110500989
Genital burning sensation 11.92 10.45 6 86290 403 110502600
Prothrombin time prolonged 11.90 10.45 35 86261 17226 110485777
Lung neoplasm 11.81 10.45 22 86274 8054 110494949
Nail infection 11.80 10.45 12 86284 2476 110500527
Poisoning deliberate 11.78 10.45 3 86293 26328 110476675
Limb reduction defect 11.75 10.45 4 86292 98 110502905
Staphylococcal infection 11.69 10.45 94 86202 69850 110433153
Hot flush 11.69 10.45 21 86275 66015 110436988
Maternal exposure during pregnancy 11.61 10.45 135 86161 254748 110248255
Cystitis noninfective 11.44 10.45 10 86286 1708 110501295
Blood test abnormal 11.41 10.45 4 86292 28550 110474453
Appendicitis 11.36 10.45 4 86292 28460 110474543
Rheumatoid arthritis 11.32 10.45 165 86131 299448 110203555
Dermatitis allergic 11.30 10.45 40 86256 21684 110481319
Meningitis Escherichia 11.21 10.45 3 86293 31 110502972
Pancreatitis 11.21 10.45 117 86179 93416 110409587
Purpura 11.09 10.45 43 86253 24345 110478658
Biopsy 11.03 10.45 7 86289 735 110502268
Cholelithiasis 11.02 10.45 86 86210 63336 110439667
Hepatitis B antibody positive 10.89 10.45 4 86292 123 110502880
Sinus disorder 10.85 10.45 6 86290 32722 110470281
Septic shock 10.84 10.45 178 86118 157350 110345653
Renal transplant 10.82 10.45 13 86283 3225 110499778
Incorrect route of product administration 10.78 10.45 21 86275 64040 110438963
Impaired work ability 10.75 10.45 45 86251 26374 110476629
Enterovirus infection 10.73 10.45 12 86284 2758 110500245
Lip ulceration 10.70 10.45 12 86284 2766 110500237
Altered visual depth perception 10.66 10.45 6 86290 506 110502497
Therapy partial responder 10.64 10.45 8 86288 37053 110465950
Areflexia 10.61 10.45 19 86277 6750 110496253
Gamma-glutamyltransferase increased 10.58 10.45 83 86213 61226 110441777
Poor venous access 10.58 10.45 3 86293 24519 110478484
Loss of personal independence in daily activities 10.57 10.45 71 86225 149949 110353054
Body temperature decreased 10.57 10.45 8 86288 36927 110466076
Suprapubic pain 10.56 10.45 8 86288 1117 110501886
Hepatitis A antibody positive 10.54 10.45 4 86292 135 110502868
Human herpesvirus 6 infection reactivation 10.53 10.45 8 86288 1121 110501882
Clostridium test positive 10.47 10.45 25 86271 10868 110492135

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01EA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Trimethoprim and derivatives
ATC J01EE01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J01EE07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J04AM08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
FDA MoA N0000000191 Dihydrofolate Reductase Inhibitors
FDA EPC N0000175489 Dihydrofolate Reductase Inhibitor Antibacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005493 Folic Acid Antagonists
MeSH PA D018726 Anti-Dyskinesia Agents
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D065687 Cytochrome P-450 CYP2C8 Inhibitors
FDA MoA N0000187061 Organic Cation Transporter 2 Inhibitors
FDA MoA N0000187062 Cytochrome P450 2C8 Inhibitors
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35498 diuretic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35718 antifungal agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:38068 antimalarial
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50683 EC 1.5.1.3 (dihydrofolate reductase) inhibitor
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:88188 drug allergen
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent

Related Drugs by ATC class:

J01EA Trimethoprim and derivatives 2 drugs
brodimoprimiclaprim
J01EE Combinations of sulfonamides and trimethoprim, incl. derivatives 7 drugs
sulfadiazinesulfadimidinesulfamerazinesulfamethoxazolesulfametrolesulfamoxoletetroxoprim
J04AM Combinations of drugs for treatment of tuberculosis 11 drugs
ethambutolisoniazidlevofloxacinlomefloxacinprotionamidepyrazinamiderifabutinrifampicinstreptomycinsulfamethoxazolethioacetazone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Acute otitis media indication 3110003
Haemophilus Influenzae Acute Otitis Media indication 19021002
Shigellosis indication 36188001
Klebsiella cystitis indication 60867007
Urinary tract infectious disease indication 68566005
Blepharoconjunctivitis indication 68659002 DOID:2456
Bacterial conjunctivitis indication 128350005 DOID:9700
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Pneumocystosis jiroveci pneumonia indication 415125002 DOID:11339
Acute exacerbation of chronic bronchitis indication 425748003
Morganella Morganii Urinary Tract Infection indication
Staphylococcus Aureus Urinary Tract Infection indication
Pneumocystis Carinii Pneumonia Prevention indication
Haemophilus Influenzae Chronic Bronchitis indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Typhoid fever off-label use 4834000 DOID:13258
Infection of skin AND/OR subcutaneous tissue off-label use 19824006
Pertussis off-label use 27836007
Granuloma inguinale off-label use 28867007 DOID:9113
Nocardiosis off-label use 29227009 DOID:2312
Listeria meningitis off-label use 31568009 DOID:11572
Sinusitis off-label use 36971009
Whipple's disease off-label use 41545003 DOID:8476
Bacterial pneumonia off-label use 53084003 DOID:874
Paracoccidioidomycosis off-label use 59925007 DOID:12662
Cholera off-label use 63650001 DOID:1498
Brucellosis off-label use 75702008 DOID:11077
Paratyphoid fever off-label use 85904008 DOID:3055
Chlamydial infection off-label use 105629000
Infection of bone off-label use 111253001
Meningococcus carrier off-label use 170486006
Lymphogranuloma venereum off-label use 186946009 DOID:13819
Chancroid off-label use 266143009 DOID:13778
Diverticulitis of gastrointestinal tract off-label use 271366000
Bacterial endocarditis off-label use 301183007
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Toxoplasmosis Prevention off-label use
Postexposure Plague Prophylaxis off-label use
Chronic Bacterial Prostatitis off-label use
Diabetic Foot Infection off-label use
Third trimester pregnancy contraindication 41587001
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Folic acid deficiency contraindication 190633005
Disease of liver contraindication 235856003 DOID:409
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Pseudomembranous enterocolitis contraindication 397683000
Porphyria contraindication 418470004




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Systemic antibacterial action against sensitive organisms to surgery Indication
Dogs Systemic antibacterial action against sensitive organisms to debridement Indication
Dogs Control of bacterial infection during the treatment of acute urinary tract infections Indication
Dogs Control of bacterial infection during the treatment of acute bacterial complications of distemper Indication
Dogs Control of bacterial infection during the treatment of acute respiratory tract infections Indication
Dogs Control of bacterial infection during the treatment of acute alimentary tract infections Indication
Dogs Control of bacterial infection during the treatment of wound infections Indication
Dogs Control of bacterial infection during the treatment of abscesses Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of acute strangles Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of respiratory tract infections Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of acute urogenital infections Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of wound infections Indication
Horses Systemic antibacterial action against sensitive organisms during treatment of abscesses Indication

🐶 Veterinary products

ProductApplicantIngredients
Tribrissen 120 Tablets, Tribrissen 30 Tablets, Tribrissen 480 Tablets, Tribrissen 960 Tablets Intervet Inc. 2
Tribrissen 24% Injection Intervet Inc. 2
Tribrissen 48% Injection Intervet Inc. 2
Di-Trim Tablets Zoetis Inc. 2
Tribrissen 400 Oral Paste Intervet Inc. 2
Di-Trim 24% Zoetis Inc. 2
Di-Trim 48% Injection Zoetis Inc. 2
Di-Trim 400 Paste Zoetis Inc. 2
Tribrissen 60 Oral Suspension Intervet Inc. 2
EQUISUL-SDT Aurora Pharmaceutical Inc. 2
Uniprim Powder Neogen Corp. 2
Tucoprim Powder Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.01 Basic
pKa2 0.6 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Solute carrier family 22 member 1 Transporter IC50 4.25 CHEMBL
Dihydrofolate reductase Enzyme Ki 8 CHEMBL
Dihydrofolate reductase Enzyme INHIBITOR IC50 5.57 CHEMBL CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 8.14 CHEMBL
Dihydrofolate reductase Enzyme Ki 6.82 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 6.92 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 7.99 CHEMBL
Dihydrofolate reductase Enzyme Ki 6.30 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.84 CHEMBL
Dihydrofolate reductase Enzyme Ki 6.88 CHEMBL
Dihydrofolate reductase Enzyme IC50 4.92 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 6.92 WOMBAT-PK
Dihydrofolate reductase Enzyme IC50 8.66 CHEMBL
Dihydrofolate reductase Enzyme IC50 6.72 CHEMBL
Dihydrofolate reductase Enzyme Ki 8.89 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 6 WOMBAT-PK
Dihydrofolate reductase Enzyme Ki 8.92 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme Ki 8 WOMBAT-PK
Dihydrofolate reductase Enzyme IC50 6.35 CHEMBL
Dihydrofolate reductase Enzyme IC50 6.35 CHEMBL
Dihydrofolate reductase Enzyme IC50 4.06 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.62 CHEMBL
Bifunctional dihydrofolate reductase-thymidylate synthase Enzyme IC50 5.40 CHEMBL
Dihydrofolate reductase type 1 Enzyme IC50 6.30 CHEMBL
Dihydrofolate reductase Enzyme Ki 8.08 CHEMBL
Dihydrofolate reductase Enzyme IC50 4.38 CHEMBL
Dihydrofolate reductase Enzyme IC50 7.04 CHEMBL

External reference:

IDSource
4017735 VUID
N0000146103 NUI
D00145 KEGG_DRUG
56585-33-2 SECONDARY_CAS_RN
60834-30-2 SECONDARY_CAS_RN
4017735 VANDF
4019528 VANDF
C0041041 UMLSCUI
CHEBI:45924 CHEBI
TOP PDB_CHEM_ID
CHEMBL22 ChEMBL_ID
CHEMBL2110367 ChEMBL_ID
DB00440 DRUGBANK_ID
CHEMBL1201080 ChEMBL_ID
D014295 MESH_DESCRIPTOR_UI
5578 PUBCHEM_CID
10931 IUPHAR_LIGAND_ID
1047 INN_ID
AN164J8Y0X UNII
10829 RXNORM
3055 MMSL
5633 MMSL
5634 MMSL
d00123 MMSL
002873 NDDF
008281 NDDF
32792001 SNOMEDCT_US
387179001 SNOMEDCT_US
412323009 SNOMEDCT_US
61971000087103 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0121-0853 SUSPENSION 40 mg ORAL NDA 23 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 0121-0854 SUSPENSION 40 mg ORAL NDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0440-2406 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0615-8121 TABLET 160 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9503 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 16 mg INTRAVENOUS ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0904-2725 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-053 TABLET 160 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-092 TABLET 160 mg ORAL ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-525 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-926 TABLET 160 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-940 TABLET 160 mg ORAL ANDA 27 sections
Sulfamethoxazole and Trimethoprim DS HUMAN PRESCRIPTION DRUG LABEL 2 12634-177 TABLET 160 mg ORAL ANDA 21 sections
SULFAMETHOXAZOLE and TRIMETHOPRIM HUMAN PRESCRIPTION DRUG LABEL 2 12634-779 SUSPENSION 40 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 16590-210 TABLET 160 mg ORAL ANDA 29 sections
Polymyxin B Sulfate and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 16590-233 SOLUTION 1 mg OPHTHALMIC ANDA 17 sections
POLYMYXIN B SULFATE AND TRIMETHOPRIM HUMAN PRESCRIPTION DRUG LABEL 2 17478-703 SOLUTION 1 mg OPHTHALMIC ANDA 19 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 17856-0007 SUSPENSION 40 mg ORAL NDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 17856-0496 SUSPENSION 40 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 17856-0823 SUSPENSION 40 mg ORAL ANDA 20 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 17856-5181 SUSPENSION 40 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 21695-125 TABLET 160 mg ORAL ANDA 13 sections
Polymyxin B Sulfate and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 21695-335 SOLUTION 1 mg OPHTHALMIC ANDA 20 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 21695-701 SUSPENSION 40 mg ORAL ANDA 20 sections
Polymyxin B Sulfate and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 24208-315 SOLUTION/ DROPS 1 mg OPHTHALMIC ANDA 20 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 33261-148 TABLET 160 mg ORAL ANDA 13 sections