terizidone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2602 25683-71-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • terizidone
  • terivalidin
  • terizidon
minor descriptor (1975-1984); on-line & Index Medicus search OXAZOLES (1975-1984); RN given refers to parent cpd without isomeric designation
  • Molecular weight: 302.29
  • Formula: C14H14N4O4
  • CLOGP: 0.56
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 101.38
  • ALOGS: -3.08
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 71.81 49.92 18 453 13499 50591154
Polyneuropathy 63.64 49.92 16 455 12115 50592538
Drug resistance 52.03 49.92 15 456 18974 50585679

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 74.73 55.81 20 418 12207 29561882

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 141.49 48.30 38 903 23792 64473999
Polyneuropathy 114.60 48.30 31 910 19863 64477928
Drug resistance 73.04 48.30 25 916 35077 64462714
Anaemia 69.00 48.30 51 890 378629 64119162
Electrocardiogram QT prolonged 56.36 48.30 26 915 79422 64418369
Psychotic disorder 54.31 48.30 20 921 34558 64463233
Bicytopenia 53.23 48.30 12 929 3610 64494181

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J04AK03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Other drugs for treatment of tuberculosis

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.06 acidic
pKa2 7.66 acidic
pKa3 3.32 Basic
pKa4 2.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07247 KEGG_DRUG
C0145184 UMLSCUI
CHEBI:135278 CHEBI
CHEMBL2107553 ChEMBL_ID
DB12954 DRUGBANK_ID
C100142 MESH_SUPPLEMENTAL_RECORD_UI
65720 PUBCHEM_CID
1707 INN_ID
1199LEX5N8 UNII
57047 RXNORM
005992 NDDF

Pharmaceutical products:

None