delamanid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4819	681492-22-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: deltyba OPC-67683 delamanid	an antitubercular agent Molecular weight: 534.49 Formula: C25H25F3N4O6 CLOGP: 5.61 LIPINSKI: 2 HAC: 10 HDO: 0 TPSA: 101.12 ALOGS: -5.38 ROTB: 9

Molecule

Description

Molfile Inchi Smiles

Synonyms:

deltyba
OPC-67683
delamanid

an antitubercular agent

Molecular weight: 534.49
Formula: C25H25F3N4O6
CLOGP: 5.61
LIPINSKI: 2
HAC: 10
HDO: 0
TPSA: 101.12
ALOGS: -5.38
ROTB: 9

Drug dosage:

Dose	Unit	Route
0.20	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
July 4, 2014	PMDA
Nov. 22, 2013	EMA

FDA Adverse Event Reporting System (Female)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Electrocardiogram QT prolonged	191.42	44.26	68	1600	59462	63427892
Anaemia	75.86	44.26	62	1606	293368	63193986
Vomiting	69.80	44.26	79	1589	559538	62927816
Off label use	62.62	44.26	82	1586	674380	62812974
Neuropathy peripheral	56.94	44.26	36	1632	113631	63373723
Intentional product use issue	53.06	44.26	36	1632	127856	63359498
Incorrect product administration duration	51.83	44.26	17	1651	11529	63475825

Showing 1 to 7 of 7 entries

Previous1Next

FDA Adverse Event Reporting System (Male)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Electrocardiogram QT prolonged	276.07	37.32	100	1983	40852	34913996
Neuropathy peripheral	100.33	37.32	62	2021	83201	34871647
Incorrect product administration duration	91.64	37.32	26	2057	4785	34950063
Intentional product use issue	80.85	37.32	48	2035	59768	34895080
Tuberculosis	80.79	37.32	27	2056	8550	34946298
Off label use	66.45	37.32	101	1982	419423	34535425
Anaemia	62.81	37.32	73	2010	233262	34721586
Vomiting	59.30	37.32	73	2010	247548	34707300
HIV infection	38.41	37.32	10	2073	1329	34953519

Showing 1 to 9 of 9 entries

Previous1Next

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Electrocardiogram QT prolonged	433.72	34.00	163	3713	90223	79650289
Neuropathy peripheral	170.44	34.00	98	3778	141207	79599305
Incorrect product administration duration	142.65	34.00	43	3833	11979	79728533
Anaemia	124.50	34.00	129	3747	444886	79295626
Intentional product use issue	121	34.00	81	3795	152031	79588481
Off label use	119.72	34.00	180	3696	907035	78833477
Vomiting	109.56	34.00	147	3729	665681	79074831
Tuberculosis	78.28	34.00	29	3847	15169	79725343
Drug-induced liver injury	59.24	34.00	38	3838	66079	79674433
Psychotic disorder	58.65	34.00	32	3844	41370	79699142

Showing 1 to 10 of 24 entries

Previous1 2 3Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	J04AK06	ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Other drugs for treatment of tuberculosis

Showing 1 to 1 of 1 entries

Previous1Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Drug resistant tuberculosis	indication	423709000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.92	Basic
pKa2	4.66	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

Show entries

Search:

ID	Source
015849	NDDF
6480466	PUBCHEM_CID
714097004	SNOMEDCT_US
714098009	SNOMEDCT_US
8OOT6M1PC7	UNII
9401	INN_ID
C3489682	UMLSCUI
C516022	MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:134742	CHEBI
CHEMBL218650	ChEMBL_ID

Showing 1 to 10 of 12 entries

Previous1 2Next

Pharmaceutical products:

None