isoniazid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1497 54-85-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • isoniazid
  • 4-Pyridinecarboxylic hydrazide
  • armazid
  • isoniazide
  • isonicotinohydrazide
Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
  • Molecular weight: 137.14
  • Formula: C6H7N3O
  • CLOGP: -0.67
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 68.01
  • ALOGS: -0.59
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O
0.30 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 140 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 72.92 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.82 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 1 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.113 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.552 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 11.194 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 2.541 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 81.190 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 78.980 % High 1
herg hERG pIC50 3.403 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 4.018 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 7.379 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 70.670 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT3,AURKB,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK1,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK1,MAPK12,MAPK7,MAPK9,MARK4,NTRK2,PAK4,PDK1,PDK2,PDK4,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 46
kinase-selectivity-class ACVR2A,AXL,BRAF,CAMK2B,CAMK2D,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,ERBB4,GRK2,IRAK1,MAP2K6,MAP3K21,MAPK7,MARK4,PIK3CD,PRKCD,ROCK1,SIK2,SIK3,STK33,ULK1 24
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.773 High 1
mh-clint Mouse hepatocyte intrinsic clearance 15.276 High 1
mppb Mouse plasma protein binding (% unbound) 92.470 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.409 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 83.400 % High 1
rh-clint Rat hepatocyte intrinsic clearance 4.989 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 97.330 % High 1
rppb Rat plasma protein binding (% unbound) 76.480 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 990.832 uM High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 29, 1952 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 943.54 14.55 385 26550 42373 90559139
Paradoxical drug reaction 655.42 14.55 179 26756 5587 90595925
Drug-induced liver injury 457.23 14.55 302 26633 90016 90511496
Acute hepatic failure 354.71 14.55 160 26775 22401 90579111
Drug resistance 352.93 14.55 175 26760 30274 90571238
Immune reconstitution inflammatory syndrome 316.61 14.55 107 26828 6912 90594600
Hepatotoxicity 314.36 14.55 186 26749 45656 90555856
Tuberculosis 293.59 14.55 118 26817 12431 90589081
Immune reconstitution inflammatory syndrome associated tuberculosis 246.65 14.55 51 26884 452 90601060
Tuberculoma of central nervous system 237.61 14.55 47 26888 325 90601187
Drug interaction 227.72 14.55 341 26594 276112 90325400
Loss of employment 223.66 14.55 67 26868 2920 90598592
Jaundice 220.43 14.55 131 26804 32386 90569126
Hepatitis 200.50 14.55 167 26768 70572 90530940
Hepatic encephalopathy 195.48 14.55 91 26844 13681 90587831
Hepatic steatosis 195.14 14.55 127 26808 36818 90564694
Pulmonary tuberculosis 191.96 14.55 67 26868 4767 90596745
Disseminated tuberculosis 143.69 14.55 49 26886 3250 90598262
Pyrexia 131.06 14.55 462 26473 660023 89941489
Hepatic failure 129.90 14.55 102 26833 39626 90561886
Vaginal flatulence 129.88 14.55 67 26868 12571 90588941
Proctitis 118.03 14.55 67 26868 15192 90586320
Vaginal discharge 117.94 14.55 73 26862 19391 90582121
Female genital tract fistula 115.91 14.55 70 26865 17798 90583714
Radiculopathy 108.58 14.55 68 26867 18437 90583075
Oral candidiasis 105.19 14.55 86 26849 35369 90566143
Encephalopathy 104.12 14.55 96 26839 46348 90555164
Hepatic function abnormal 102.45 14.55 95 26840 46193 90555319
Cerebellar ataxia 97.23 14.55 27 26908 895 90600617
Chronic sinusitis 95.31 14.55 69 26866 23733 90577779
Transaminases increased 91.47 14.55 81 26854 37111 90564401
Exposure during pregnancy 85.05 14.55 206 26729 238204 90363308
Eosinophilia 84.20 14.55 69 26866 28464 90573048
Lymphadenopathy 82.61 14.55 84 26851 45691 90555821
Alanine aminotransferase increased 80.60 14.55 134 26801 118204 90483308
Aspartate aminotransferase increased 80.29 14.55 124 26811 102813 90498699
Fatigue 80.13 14.55 138 26797 1153885 89447627
Paraesthesia oral 79.95 14.55 70 26865 31589 90569923
Myocarditis 79.16 14.55 50 26885 13756 90587756
Glossodynia 79.09 14.55 4 26931 321775 90279737
Multiple organ dysfunction syndrome 76.66 14.55 98 26837 68238 90533274
Procedural pain 74.85 14.55 69 26866 33291 90568221
Wound 73.73 14.55 4 26931 302976 90298536
Meningitis tuberculous 72.76 14.55 20 26915 638 90600874
Hand deformity 71.84 14.55 4 26931 296358 90305154
Arthropathy 70.56 14.55 12 26923 366230 90235282
Synovitis 70.11 14.55 8 26927 329744 90271768
Pancreatitis haemorrhagic 68.41 14.55 19 26916 630 90600882
Lymph node tuberculosis 68.33 14.55 20 26915 803 90600709
Cardiac failure 64.11 14.55 116 26819 109380 90492132
Hypertransaminasaemia 63.63 14.55 46 26889 15779 90585733
Cardiac failure congestive 60.92 14.55 107 26828 98587 90502925
Face oedema 59.77 14.55 52 26883 23266 90578246
Alopecia 59.29 14.55 37 26898 495034 90106478
Pneumocystis jirovecii pneumonia 59.06 14.55 50 26885 21566 90579946
Congestive hepatopathy 58.98 14.55 25 26910 3008 90598504
Tuberculosis gastrointestinal 57.47 14.55 15 26920 391 90601121
Swelling 56.44 14.55 27 26908 419031 90182481
Joint swelling 55.74 14.55 41 26894 503259 90098253
Helicobacter infection 55.16 14.55 3 26932 226847 90374665
Discomfort 55.06 14.55 8 26927 274327 90327185
Colitis ulcerative 54.74 14.55 78 26857 60188 90541324
Systemic lupus erythematosus 54.05 14.55 20 26915 361876 90239636
Generalised tonic-clonic seizure 53.98 14.55 59 26876 34844 90566668
Mycobacterium tuberculosis complex test positive 52.36 14.55 22 26913 2590 90598922
Tuberculin test positive 50.95 14.55 24 26911 3701 90597811
Hepatitis toxic 50.95 14.55 24 26911 3701 90597811
Hepatocellular injury 50.18 14.55 52 26883 28906 90572606
Latent tuberculosis 49.60 14.55 22 26913 2954 90598558
Hepatosplenomegaly 49.36 14.55 22 26913 2987 90598525
Fibromyalgia 49.32 14.55 3 26932 206266 90395246
Haematochezia 49.20 14.55 81 26854 70832 90530680
Glomerulonephritis minimal lesion 49.09 14.55 13 26922 359 90601153
Liver disorder 48.88 14.55 110 26825 121159 90480353
Sinusitis 47.91 14.55 21 26914 343067 90258445
Pericarditis 47.51 14.55 11 26924 270140 90331372
Gastric disorder 47.45 14.55 54 26881 33330 90568182
Colitis 45.99 14.55 78 26857 69864 90531648
Folliculitis 45.91 14.55 4 26931 204349 90397163
Serotonin syndrome 45.13 14.55 56 26879 37831 90563681
Aspergillus infection 44.75 14.55 32 26903 10791 90590721
Liver transplant 44.73 14.55 19 26916 2298 90599214
Impaired healing 44.37 14.55 8 26927 234191 90367321
Treatment noncompliance 44.13 14.55 65 26870 51662 90549850
Hepatitis fulminant 43.68 14.55 22 26913 3923 90597589
Frequent bowel movements 43.55 14.55 68 26867 56867 90544645
Wheezing 43.27 14.55 9 26926 238071 90363441
Drug level decreased 43.09 14.55 30 26905 9700 90591812
Toxicity to various agents 42.65 14.55 184 26751 287662 90313850
Lower respiratory tract infection 42.53 14.55 11 26924 250648 90350864
Coagulopathy 42.49 14.55 43 26892 23246 90578266
Anaemia 42.32 14.55 212 26723 352590 90248922
Multiple-drug resistance 41.69 14.55 27 26908 7749 90593763
Neurotoxicity 41.68 14.55 41 26894 21426 90580086
Contusion 40.80 14.55 12 26923 251204 90350308
Ill-defined disorder 40.52 14.55 4 26931 184887 90416625
Macular degeneration 40.30 14.55 53 26882 37917 90563595
Mycoplasma genitalium infection 40.15 14.55 7 26928 21 90601491
Liver function test abnormal 39.27 14.55 61 26874 50784 90550728
Pleural effusion 39.05 14.55 96 26839 111895 90489617
Injury 39.03 14.55 6 26929 197343 90404169
Rash maculo-papular 38.68 14.55 54 26881 40879 90560633
Oedematous kidney 38.46 14.55 9 26926 147 90601365
Peripheral swelling 38.04 14.55 40 26895 413066 90188446
Distributive shock 37.64 14.55 19 26916 3405 90598107
Erythema 37.43 14.55 151 26784 229095 90372417
Mobility decreased 37.18 14.55 14 26921 250720 90350792
Sleep disorder 37.00 14.55 7 26928 198023 90403489
Infection 36.91 14.55 32 26903 362062 90239450
Focal dyscognitive seizures 36.19 14.55 18 26917 3126 90598386
Hepatic necrosis 36.11 14.55 23 26912 6415 90595097
Hepatic haematoma 35.66 14.55 11 26924 529 90600983
Oedematous pancreatitis 35.52 14.55 12 26923 773 90600739
Dry mouth 35.49 14.55 6 26929 184053 90417459
Peritoneal tuberculosis 35.16 14.55 11 26924 555 90600957
Encephalitis 35.12 14.55 28 26907 11106 90590406
Product dose omission issue 33.25 14.55 23 26912 291664 90309848
Fall 32.91 14.55 58 26877 481752 90119760
Memory impairment 32.80 14.55 9 26926 197235 90404277
Nasopharyngitis 32.60 14.55 44 26891 407060 90194452
Pericardial effusion 32.45 14.55 47 26888 36786 90564726
Osteoarthritis 32.42 14.55 9 26926 195721 90405791
Blood cholesterol increased 31.88 14.55 11 26924 208001 90393511
Psoriatic arthropathy 31.82 14.55 14 26921 228321 90373191
Nicotinic acid deficiency 31.55 14.55 7 26928 89 90601423
Pathogen resistance 31.29 14.55 23 26912 8092 90593420
Rectal haemorrhage 31.06 14.55 73 26862 82671 90518841
Disseminated intravascular coagulation 30.88 14.55 35 26900 21503 90580009
Nausea 30.28 14.55 480 26455 1109836 89491676
Shock 30.28 14.55 40 26895 28738 90572774
Cholestatic liver injury 30.24 14.55 17 26918 3780 90597732
Hemianopia heteronymous 29.90 14.55 6 26929 45 90601467
Muscle spasms 29.87 14.55 19 26916 251864 90349648
Jarisch-Herxheimer reaction 29.30 14.55 9 26926 427 90601085
Tuberculous pleurisy 29.12 14.55 9 26926 436 90601076
Type I hypersensitivity 28.82 14.55 17 26918 4138 90597374
Malaise 28.77 14.55 283 26652 585703 90015809
Gamma-glutamyltransferase increased 28.57 14.55 45 26890 37907 90563605
Pancreatitis acute 28.32 14.55 41 26894 32074 90569438
Stomatitis 28.32 14.55 24 26911 274674 90326838
Bovine tuberculosis 28.18 14.55 6 26929 62 90601450
Blister 27.89 14.55 21 26914 254977 90346535
Hydrocephalus 27.48 14.55 19 26916 6075 90595437
Joint range of motion decreased 27.10 14.55 4 26931 135639 90465873
Musculoskeletal stiffness 26.96 14.55 29 26906 296503 90305009
Gastrooesophageal reflux disease 26.90 14.55 8 26927 166329 90435183
Ocular icterus 26.86 14.55 16 26919 3964 90597548
Rash morbilliform 26.68 14.55 16 26919 4013 90597499
Anxiety 26.32 14.55 32 26903 309740 90291772
Insomnia 25.73 14.55 37 26898 333437 90268075
Depression 25.59 14.55 31 26904 300570 90300942
Hypoaesthesia 25.10 14.55 34 26901 314176 90287336
Granuloma 24.91 14.55 18 26917 6167 90595345
Toxic optic neuropathy 24.78 14.55 7 26928 247 90601265
Weight increased 24.49 14.55 55 26880 417872 90183640
Liver injury 23.69 14.55 107 26828 170460 90431052
Seizure 23.68 14.55 99 26836 152530 90448982
Optic neuritis 23.63 14.55 21 26914 9657 90591855
Immune system disorder 23.60 14.55 23 26912 11882 90589630
Hyperinsulinaemia 23.54 14.55 6 26929 142 90601370
Substance-induced psychotic disorder 23.09 14.55 13 26922 2899 90598613
Migraine 23.07 14.55 14 26921 190378 90411134
Interstitial lung disease 23.01 14.55 62 26873 76343 90525169
Blood bilirubin increased 22.86 14.55 44 26891 43426 90558086
Pseudomonas infection 22.76 14.55 25 26910 14840 90586672
Status epilepticus 22.64 14.55 28 26907 18846 90582666
Mastitis bacterial 22.58 14.55 5 26930 63 90601449
Hepatitis B core antibody positive 22.55 14.55 7 26928 344 90601168
Microcytic anaemia 22.32 14.55 14 26921 3804 90597708
Bilirubin conjugated increased 22.22 14.55 13 26922 3117 90598395
Pseudomembranous colitis 22.15 14.55 14 26921 3854 90597658
Cardiac arrest 22.03 14.55 75 26860 104860 90496652
Pain in extremity 22.01 14.55 65 26870 450464 90151048
Trichophytosis 21.96 14.55 5 26930 72 90601440
Stillbirth 21.95 14.55 18 26917 7425 90594087
Electrocardiogram ST segment elevation 21.67 14.55 14 26921 4002 90597510
Hyperuricaemia 21.41 14.55 17 26918 6702 90594810
General physical health deterioration 21.41 14.55 46 26889 355069 90246443
Optic neuropathy 21.27 14.55 12 26923 2686 90598826
Pericarditis tuberculous 21.16 14.55 4 26931 21 90601491
Intentional product use issue 21.09 14.55 20 26915 216872 90384640
Respiratory failure 20.92 14.55 80 26855 118338 90483174
Hyperbilirubinaemia 20.58 14.55 23 26912 13913 90587599
Asthma 20.58 14.55 25 26910 242135 90359377
Intentional overdose 20.53 14.55 68 26867 93766 90507746
Inflammation 20.45 14.55 14 26921 178578 90422934
Sciatica 20.22 14.55 3 26932 101379 90500133
Liver transplant rejection 20.21 14.55 10 26925 1718 90599794
Acute respiratory distress syndrome 20.20 14.55 33 26902 28653 90572859
Disseminated aspergillosis 20.20 14.55 7 26928 487 90601025
Interferon gamma release assay positive 20.18 14.55 5 26930 105 90601407
Central venous pressure increased 20.09 14.55 5 26930 107 90601405
Hypercholesterolaemia 20.09 14.55 3 26932 100889 90500623
Abdominal pain upper 20.03 14.55 168 26767 332506 90269006
Pain 19.85 14.55 195 26740 996146 89605366
Tuberculosis of genitourinary system 19.71 14.55 4 26931 32 90601480
Hepatomegaly 19.69 14.55 22 26913 13304 90588208
Hepatic cytolysis 19.69 14.55 34 26901 30882 90570630
Infectious pleural effusion 19.18 14.55 10 26925 1915 90599597
Musculoskeletal pain 18.85 14.55 14 26921 171237 90430275
Pneumonia lipoid 18.85 14.55 5 26930 139 90601373
Blood beta-D-glucan increased 18.82 14.55 6 26929 322 90601190
Dizziness 18.64 14.55 101 26834 589183 90012329
Abdominal lymphadenopathy 18.53 14.55 8 26927 1007 90600505
Joint tuberculosis 18.29 14.55 5 26930 156 90601356
Maternal exposure during breast feeding 18.26 14.55 15 26920 6205 90595307
Nephrotic syndrome 18.07 14.55 16 26919 7323 90594189
Cough 17.97 14.55 178 26757 368784 90232728
Strongyloidiasis 17.93 14.55 9 26926 1593 90599919
Abdominal pain 17.89 14.55 188 26747 395533 90205979
Hepatitis acute 17.87 14.55 19 26916 10868 90590644
Ascites 17.78 14.55 42 26893 47698 90553814
AIDS related complication 17.76 14.55 3 26932 7 90601505
Hepatic cyst 17.54 14.55 15 26920 6553 90594959
Gait inability 17.42 14.55 11 26924 146445 90455067
Cytomegalovirus chorioretinitis 17.05 14.55 10 26925 2409 90599103
Drug level increased 16.99 14.55 30 26905 27732 90573780
Death 16.89 14.55 74 26861 456477 90145035
Rhabdomyolysis 16.87 14.55 43 26892 51213 90550299
Feeling abnormal 16.76 14.55 15 26920 167220 90434292
Mycobacterium avium complex infection 16.67 14.55 12 26923 4086 90597426
Cytomegalovirus infection 16.60 14.55 29 26906 26573 90574939
Metabolic acidosis 16.58 14.55 45 26890 55631 90545881
Chest pain 16.42 14.55 45 26890 319600 90281912
Liver palpable 16.35 14.55 3 26932 13 90601499
Aplasia pure red cell 16.25 14.55 13 26922 5181 90596331
Pneumothorax 16.22 14.55 24 26911 19143 90582369
Stevens-Johnson syndrome 15.77 14.55 30 26905 29346 90572166
Intraventricular haemorrhage neonatal 15.72 14.55 5 26930 266 90601246
Psychotic disorder 15.68 14.55 31 26904 31199 90570313
Hypersensitivity myocarditis 15.46 14.55 5 26930 281 90601231
Transplant rejection 15.42 14.55 19 26916 12739 90588773
Mycobacterial infection 15.22 14.55 9 26926 2201 90599311
Acid fast bacilli infection 15.15 14.55 4 26931 109 90601403
Haemodilution 15.08 14.55 4 26931 111 90601401
Cerebrovascular accident 15.08 14.55 9 26926 123524 90477988
Bone tuberculosis 15.00 14.55 5 26930 309 90601203
Cachexia 14.98 14.55 14 26921 6864 90594648
Congenital skin dimples 14.95 14.55 4 26931 115 90601397
Pancytopenia 14.90 14.55 73 26862 120190 90481322
Type IV hypersensitivity reaction 14.85 14.55 11 26924 3915 90597597
Intestinal tuberculosis 14.69 14.55 4 26931 123 90601389
Cell-mediated cytotoxicity 14.67 14.55 3 26932 25 90601487
Coma hepatic 14.67 14.55 6 26929 660 90600852
Gait disturbance 14.67 14.55 35 26900 260461 90341051
Confusional state 14.65 14.55 62 26873 386143 90215369
Low birth weight baby 14.63 14.55 16 26919 9451 90592061
Renal transplant failure 14.58 14.55 7 26928 1125 90600387
Amnesia 14.57 14.55 7 26928 108498 90493014

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Paradoxical drug reaction 1119.36 14.46 299 23474 4439 42593123
Drug-induced liver injury 630.19 14.46 342 23431 37931 42559631
Immune reconstitution inflammatory syndrome 559.13 14.46 211 23562 9932 42587630
Drug reaction with eosinophilia and systemic symptoms 464.10 14.46 290 23483 41785 42555777
Hepatotoxicity 403.11 14.46 221 23552 24946 42572616
Immune reconstitution inflammatory syndrome associated tuberculosis 333.76 14.46 75 23698 506 42597056
Drug resistance 318.12 14.46 212 23561 34036 42563526
Jaundice 309.02 14.46 209 23564 34380 42563182
Tuberculosis 274.62 14.46 127 23646 9972 42587590
Pulmonary tuberculosis 217.31 14.46 90 23683 5411 42592151
Hepatitis 201.89 14.46 147 23626 27153 42570409
Tuberculoma of central nervous system 189.21 14.46 41 23732 228 42597334
Drug interaction 168.05 14.46 422 23351 266577 42330985
Disseminated tuberculosis 110.83 14.46 46 23727 2778 42594784
Meningitis tuberculous 97.21 14.46 29 23744 650 42596912
Pyrexia 97.04 14.46 455 23318 393587 42203975
Acute hepatic failure 93.56 14.46 77 23696 16996 42580566
Immune system disorder 88.26 14.46 50 23723 5994 42591568
Mycobacterial infection 86.64 14.46 38 23735 2630 42594932
Alanine aminotransferase increased 85.10 14.46 166 23607 88240 42509322
Drug level decreased 83.57 14.46 58 23715 9919 42587643
Hepatic function abnormal 83.23 14.46 122 23651 51445 42546117
Hydrocephalus 77.39 14.46 46 23727 6032 42591530
Granuloma 77.33 14.46 40 23733 4001 42593561
Death 73.81 14.46 93 23680 471092 42126470
Optic neuritis 73.56 14.46 39 23734 4103 42593459
Hepatitis toxic 71.99 14.46 33 23740 2534 42595028
Liver function test abnormal 67.92 14.46 87 23686 32304 42565258
Lymph node tuberculosis 64.70 14.46 20 23753 507 42597055
Lymphadenopathy 62.81 14.46 85 23688 33280 42564282
Tuberculosis of central nervous system 61.63 14.46 16 23757 210 42597352
Hepatic failure 61.26 14.46 90 23683 38010 42559552
Hepatic enzyme increased 60.80 14.46 99 23674 45685 42551877
Fall 59.87 14.46 28 23745 234492 42363070
Aspartate aminotransferase increased 59.14 14.46 132 23641 77031 42520531
Tuberculosis of eye 58.62 14.46 12 23761 48 42597514
Optic neuropathy 57.27 14.46 28 23745 2484 42595078
Tuberculous pleurisy 55.22 14.46 17 23756 425 42597137
Tubulointerstitial nephritis 54.33 14.46 77 23696 31471 42566091
Bone tuberculosis 54.23 14.46 17 23756 452 42597110
Multiple-drug resistance 53.11 14.46 39 23734 7283 42590279
Transaminases increased 49.03 14.46 75 23698 32810 42564752
Pyelonephritis fungal 47.75 14.46 11 23762 84 42597478
Drug abuse 46.60 14.46 3 23770 104768 42492794
Tuberculosis gastrointestinal 45.79 14.46 13 23760 243 42597319
Mycobacterium tuberculosis complex test positive 43.87 14.46 20 23753 1516 42596046
Liver disorder 43.77 14.46 79 23694 39565 42557997
Granulomatous liver disease 43.74 14.46 16 23757 687 42596875
Eosinophilia 43.48 14.46 71 23702 32828 42564734
Latent tuberculosis 42.33 14.46 20 23753 1645 42595917
Skin disorder 41.12 14.46 49 23724 16895 42580667
Product dose omission issue 40.03 14.46 18 23755 154347 42443215
Hepatitis fulminant 39.59 14.46 28 23745 4931 42592631
Hepatitis cholestatic 39.17 14.46 37 23736 9787 42587775
Blood bilirubin increased 38.99 14.46 78 23695 42174 42555388
Diaphragmatic injury 38.89 14.46 10 23763 126 42597436
Optic atrophy 38.01 14.46 17 23756 1232 42596330
Demodicidosis 38.00 14.46 11 23762 221 42597341
Central nervous system vasculitis 37.86 14.46 14 23759 620 42596942
Drug eruption 37.79 14.46 55 23718 23020 42574542
Complications of transplanted kidney 37.69 14.46 28 23745 5322 42592240
Thalamic infarction 37.66 14.46 15 23758 814 42596748
Gingivitis ulcerative 37.45 14.46 11 23762 233 42597329
Interferon gamma release assay positive 37.28 14.46 10 23763 150 42597412
Tuberculin test positive 35.74 14.46 16 23757 1162 42596400
Toxic epidermal necrolysis 35.71 14.46 58 23715 26692 42570870
Dermatitis exfoliative generalised 35.57 14.46 28 23745 5796 42591766
Pain 35.49 14.46 51 23722 244797 42352765
Condition aggravated 34.44 14.46 256 23517 260498 42337064
Pathogen resistance 34.41 14.46 37 23736 11413 42586149
Encephalitis 33.69 14.46 33 23740 9125 42588437
Rash maculo-papular 33.13 14.46 68 23705 37435 42560127
Urinary tract inflammation 32.95 14.46 10 23763 238 42597324
Papilloma 32.77 14.46 11 23762 365 42597197
Hypotension 32.33 14.46 59 23714 257572 42339990
Dyspnoea 31.89 14.46 133 23640 442488 42155074
Liver injury 31.88 14.46 46 23727 19102 42578460
Bovine tuberculosis 31.25 14.46 8 23765 99 42597463
Splenic embolism 31.11 14.46 10 23763 289 42597273
Accelerated hypertension 30.98 14.46 10 23763 293 42597269
Lichenoid keratosis 30.84 14.46 22 23751 3928 42593634
Atrial fibrillation 29.41 14.46 21 23752 139572 42457990
Immunosuppressant drug level decreased 29.11 14.46 16 23757 1808 42595754
Sideroblastic anaemia 29.10 14.46 10 23763 357 42597205
Peritoneal tuberculosis 29.07 14.46 10 23763 358 42597204
Strongyloidiasis 28.85 14.46 20 23753 3411 42594151
Constipation 28.59 14.46 29 23744 162262 42435300
Febrile neutropenia 28.59 14.46 37 23736 185666 42411896
Vitamin B1 decreased 28.58 14.46 10 23763 377 42597185
Hepatic encephalopathy 28.11 14.46 40 23733 16402 42581160
Type III immune complex mediated reaction 28.08 14.46 11 23762 571 42596991
Malignant neoplasm progression 27.53 14.46 13 23760 108387 42489175
Hyperuricaemia 27.52 14.46 30 23743 9394 42588168
Liver transplant rejection 26.83 14.46 17 23756 2496 42595066
Hepatic necrosis 26.49 14.46 20 23753 3893 42593669
Adrenocortical insufficiency acute 26.22 14.46 16 23757 2199 42595363
Diarrhoea 25.96 14.46 151 23622 460698 42136864
Herpes zoster meningoencephalitis 25.75 14.46 10 23763 507 42597055
Dermatitis exfoliative 25.49 14.46 25 23748 6922 42590640
Marrow hyperplasia 25.38 14.46 13 23760 1274 42596288
Ocular toxicity 24.91 14.46 9 23764 373 42597189
Pulmonary granuloma 24.82 14.46 14 23759 1663 42595899
Urogenital infection bacterial 24.60 14.46 6 23767 60 42597502
Colour blindness 24.57 14.46 9 23764 388 42597174
Oral candidiasis 24.56 14.46 35 23738 14370 42583192
Henoch-Schonlein purpura 24.10 14.46 15 23758 2135 42595427
Encephalopathy 23.42 14.46 63 23710 41270 42556292
Hypermetabolism 23.21 14.46 8 23765 288 42597274
Myocardial infarction 23.19 14.46 21 23752 123988 42473574
Thrombosis 23.07 14.46 5 23768 68506 42529056
Unmasking of previously unidentified disease 23.04 14.46 12 23761 1217 42596345
Hepatic cytolysis 22.91 14.46 48 23725 26796 42570766
Mitochondrial neurogastrointestinal encephalopathy 22.73 14.46 4 23769 5 42597557
Haemophagocytic lymphohistiocytosis 22.29 14.46 38 23735 18184 42579378
Conductive deafness 22.26 14.46 9 23764 508 42597054
Hepatocellular injury 22.18 14.46 44 23729 23634 42573928
Mycobacterium abscessus infection 22.03 14.46 10 23763 750 42596812
Pancytopenia 21.85 14.46 126 23647 117617 42479945
Infective aneurysm 21.76 14.46 11 23762 1048 42596514
Feeling abnormal 21.73 14.46 6 23767 69780 42527782
Nasopharyngitis 21.44 14.46 10 23763 83986 42513576
Genitourinary tract infection 21.04 14.46 6 23767 114 42597448
Liver transplant 21.03 14.46 15 23758 2676 42594886
Bilirubin conjugated increased 21.01 14.46 17 23756 3660 42593902
Completed suicide 20.99 14.46 14 23759 96451 42501111
Renal transplant failure 20.76 14.46 12 23761 1493 42596069
Mycobacterium fortuitum infection 20.54 14.46 8 23765 409 42597153
Chronic obstructive pulmonary disease 20.46 14.46 5 23768 63109 42534453
Cutaneous tuberculosis 20.34 14.46 6 23767 129 42597433
Hepatitis acute 20.22 14.46 25 23748 8950 42588612
Splenic abscess 20.17 14.46 9 23764 649 42596913
Pulmonary sequestration 20.15 14.46 5 23768 54 42597508
Generalised tonic-clonic seizure 20.04 14.46 45 23728 26334 42571228
Injection site pain 19.91 14.46 4 23769 57794 42539768
Insomnia 19.84 14.46 22 23751 118231 42479331
Enterovesical fistula 19.77 14.46 10 23763 954 42596608
Hypertransaminasaemia 19.67 14.46 25 23748 9202 42588360
Palpable purpura 19.40 14.46 7 23766 289 42597273
Tuberculoid leprosy 19.23 14.46 5 23768 66 42597496
Dilatation intrahepatic duct acquired 18.96 14.46 5 23768 70 42597492
Fatigue 18.92 14.46 154 23619 435487 42162075
Extrapulmonary tuberculosis 18.88 14.46 6 23767 167 42597395
Disseminated intravascular coagulation 18.50 14.46 42 23731 24752 42572810
Autoimmune haemolytic anaemia 18.23 14.46 19 23754 5652 42591910
Implant site infection 18.02 14.46 10 23763 1151 42596411
Treatment noncompliance 18.00 14.46 54 23719 37618 42559944
Psoas abscess 18.00 14.46 9 23764 838 42596724
Trisomy 21 17.96 14.46 8 23765 574 42596988
COVID-19 17.93 14.46 23 23750 115925 42481637
Past-pointing 17.92 14.46 4 23769 26 42597536
Blood alkaline phosphatase increased 17.83 14.46 50 23723 33547 42564015
Papule 17.81 14.46 19 23754 5807 42591755
Lymphopenia 17.76 14.46 38 23735 21525 42576037
Splenomegaly 17.58 14.46 33 23740 17014 42580548
Chronic allograft nephropathy 17.54 14.46 11 23762 1587 42595975
Spermatozoa progressive motility abnormal 17.43 14.46 4 23769 30 42597532
Face oedema 17.38 14.46 29 23744 13637 42583925
Cachexia 17.34 14.46 22 23751 8082 42589480
Granulomatous lymphadenitis 17.30 14.46 6 23767 220 42597342
Hemianopia heteronymous 16.98 14.46 4 23769 34 42597528
Renal atrophy 16.92 14.46 10 23763 1297 42596265
Protrusion tongue 16.88 14.46 6 23767 237 42597325
Delayed graft function 16.81 14.46 13 23760 2622 42594940
Coma hepatic 16.66 14.46 7 23766 436 42597126
Cardiac failure congestive 16.60 14.46 14 23759 85588 42511974
Cryptococcosis 16.58 14.46 14 23759 3197 42594365
Myxoedema coma 16.39 14.46 6 23767 258 42597304
Acid fast bacilli infection 16.20 14.46 5 23768 126 42597436
Leprosy 16.13 14.46 5 23768 128 42597434
Brain oedema 16.09 14.46 31 23742 16296 42581266
Coronary artery disease 16.02 14.46 5 23768 53715 42543847
Ototoxicity 16.00 14.46 12 23761 2313 42595249
Skin lesion 15.98 14.46 42 23731 27132 42570430
Erythrodermic psoriasis 15.89 14.46 9 23764 1077 42596485
Optic disc hyperaemia 15.87 14.46 3 23770 7 42597555
Disseminated Bacillus Calmette-Guerin infection 15.67 14.46 6 23767 293 42597269
Muscle spasms 15.57 14.46 15 23758 86029 42511533
Splenic infarction 15.52 14.46 12 23761 2419 42595143
Disease progression 15.37 14.46 36 23737 143620 42453942
Bradycardia 15.36 14.46 15 23758 85469 42512093
Osteolysis 15.27 14.46 14 23759 3566 42593996
Neuropathy peripheral 15.14 14.46 103 23670 101750 42495812
Testicular mass 15.10 14.46 5 23768 159 42597403
Peripheral swelling 14.92 14.46 17 23756 90253 42507309
Coagulopathy 14.86 14.46 36 23737 22126 42575436
Lupus-like syndrome 14.76 14.46 13 23760 3141 42594421
Pancreatic pseudocyst 14.72 14.46 8 23765 884 42596678
Transferrin decreased 14.67 14.46 5 23768 174 42597388
Cholestasis 14.66 14.46 46 23727 32833 42564729
Hereditary optic atrophy 14.56 14.46 4 23769 66 42597496
Abdominal rebound tenderness 14.46 14.46 3 23770 13 42597549

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Paradoxical drug reaction 1702.32 13.07 458 46329 9359 110533153
Drug reaction with eosinophilia and systemic symptoms 1337.17 13.07 665 46122 81430 110461082
Drug-induced liver injury 1008.14 13.07 629 46158 119438 110423074
Immune reconstitution inflammatory syndrome 863.76 13.07 306 46481 15920 110526592
Hepatotoxicity 644.90 13.07 376 46411 63024 110479488
Drug resistance 599.03 13.07 344 46443 56030 110486482
Immune reconstitution inflammatory syndrome associated tuberculosis 591.40 13.07 127 46660 927 110541585
Jaundice 544.14 13.07 329 46458 58907 110483605
Tuberculosis 500.51 13.07 211 46576 17563 110524949
Acute hepatic failure 448.43 13.07 245 46542 36223 110506289
Pulmonary tuberculosis 402.84 13.07 150 46637 8989 110533523
Tuberculoma of central nervous system 384.07 13.07 81 46706 536 110541976
Drug interaction 380.99 13.07 724 46063 499459 110043053
Hepatitis 299.36 13.07 271 46516 89783 110452729
Pyrexia 223.22 13.07 858 45929 897407 109645105
Disseminated tuberculosis 206.96 13.07 79 46708 5067 110537445
Loss of employment 196.80 13.07 68 46719 3276 110539236
Hepatic encephalopathy 182.85 13.07 126 46661 28130 110514382
Hepatic function abnormal 168.05 13.07 198 46589 89097 110453415
Meningitis tuberculous 167.90 13.07 48 46739 1230 110541282
Hepatic failure 155.94 13.07 168 46619 68571 110473941
Lymphadenopathy 143.02 13.07 155 46632 63680 110478832
Drug level decreased 139.94 13.07 91 46696 18457 110524055
Alanine aminotransferase increased 139.31 13.07 266 46521 183507 110359005
Lymph node tuberculosis 129.64 13.07 38 46749 1066 110541446
Hepatic steatosis 119.00 13.07 124 46663 48707 110493805
Transaminases increased 118.31 13.07 140 46647 63250 110479262
Eosinophilia 118.27 13.07 134 46653 57802 110484710
Hepatitis toxic 117.43 13.07 55 46732 5866 110536646
Aspartate aminotransferase increased 115.70 13.07 227 46560 159709 110382803
Immune system disorder 113.69 13.07 71 46716 13430 110529082
Vaginal flatulence 110.24 13.07 67 46720 12077 110530435
Oral candidiasis 109.68 13.07 114 46673 44646 110497866
Hydrocephalus 109.26 13.07 63 46724 10312 110532200
Vaginal discharge 100.00 13.07 73 46714 17835 110524677
Female genital tract fistula 98.33 13.07 70 46717 16449 110526063
Liver function test abnormal 95.05 13.07 131 46656 68819 110473693
Mycobacterial infection 93.73 13.07 43 46744 4374 110538138
Fall 91.27 13.07 73 46714 603409 109939103
Proctitis 90.01 13.07 67 46720 16860 110525652
Tuberculosis gastrointestinal 89.36 13.07 25 46762 591 110541921
Radiculopathy 88.49 13.07 70 46717 19266 110523246
Multiple-drug resistance 87.93 13.07 60 46727 13175 110529337
Granuloma 87.80 13.07 53 46734 9437 110533075
Optic neuropathy 85.43 13.07 41 46746 4617 110537895
Optic neuritis 84.84 13.07 55 46732 11092 110531420
Encephalopathy 84.40 13.07 135 46652 80920 110461592
Synovitis 81.57 13.07 10 46777 274082 110268430
Wound 79.34 13.07 5 46782 234432 110308080
Latent tuberculosis 79.05 13.07 37 46750 3940 110538572
Fatigue 78.40 13.07 259 46528 1215699 109326813
Glossodynia 77.39 13.07 4 46783 222000 110320512
Hepatitis fulminant 74.56 13.07 46 46741 8514 110533998
Tuberculosis of central nervous system 74.29 13.07 21 46766 516 110541996
Hypertransaminasaemia 72.79 13.07 69 46718 24186 110518326
Chronic sinusitis 72.70 13.07 70 46717 25014 110517498
Generalised tonic-clonic seizure 72.54 13.07 102 46685 54578 110487934
Rash maculo-papular 71.03 13.07 119 46668 74103 110468409
Lower respiratory tract infection 69.64 13.07 10 46777 243096 110299416
Arthropathy 69.36 13.07 18 46769 287504 110255008
Pemphigus 68.56 13.07 6 46781 214564 110327948
Peritoneal tuberculosis 67.93 13.07 20 46767 570 110541942
Bone tuberculosis 67.70 13.07 21 46766 717 110541795
Hand deformity 67.46 13.07 7 46780 218499 110324013
Hepatocellular injury 66.48 13.07 94 46693 50548 110491964
Face oedema 65.91 13.07 76 46711 33393 110509119
Encephalitis 65.11 13.07 58 46729 18781 110523731
Helicobacter infection 64.27 13.07 3 46784 181874 110360638
Product dose omission issue 63.98 13.07 28 46759 321754 110220758
Liver transplant 62.44 13.07 33 46754 4556 110537956
Pathogen resistance 62.26 13.07 55 46732 17617 110524895
Nasopharyngitis 61.73 13.07 46 46741 394315 110148197
Hepatic necrosis 61.26 13.07 43 46744 9879 110532633
Joint swelling 60.36 13.07 59 46728 442786 110099726
Tuberculous pleurisy 60.21 13.07 19 46768 687 110541825
Fibromyalgia 59.81 13.07 3 46784 170906 110371606
Wheezing 59.64 13.07 17 46770 255213 110287299
Drug abuse 59.38 13.07 4 46783 177407 110365105
Blood bilirubin increased 58.78 13.07 111 46676 75861 110466651
Peripheral swelling 58.41 13.07 51 46736 403983 110138529
Liver disorder 57.73 13.07 161 46626 142082 110400430
Paraesthesia oral 57.32 13.07 71 46716 33600 110508912
Pancreatitis haemorrhagic 57.24 13.07 20 46767 996 110541516
Treatment noncompliance 56.91 13.07 107 46680 72883 110469629
Coagulopathy 56.78 13.07 78 46709 40833 110501679
Discomfort 56.68 13.07 11 46776 214696 110327816
Dry mouth 55.49 13.07 9 46778 199939 110342573
Complications of transplanted kidney 54.88 13.07 36 46751 7406 110535106
Mycobacterium tuberculosis complex test positive 54.47 13.07 27 46760 3261 110539251
Death 54.33 13.07 136 46651 698733 109843779
Alopecia 53.99 13.07 45 46742 364708 110177804
Tubulointerstitial nephritis 53.22 13.07 88 46699 54196 110488316
Swelling 52.34 13.07 43 46744 350998 110191514
Impaired healing 52.09 13.07 10 46777 196707 110345805
Granulomatous liver disease 52.02 13.07 21 46766 1563 110540949
Procedural pain 51.16 13.07 69 46718 35496 110507016
Systemic lupus erythematosus 50.76 13.07 22 46765 254316 110288196
Contusion 50.16 13.07 18 46769 233343 110309169
Liver transplant rejection 50.01 13.07 27 46760 3891 110538621
Bovine tuberculosis 49.41 13.07 12 46775 159 110542353
Macular degeneration 49.20 13.07 53 46734 21606 110520906
Insomnia 49.17 13.07 48 46739 360542 110181970
Injury 49.14 13.07 8 46779 177257 110365255
Strongyloidiasis 49.12 13.07 29 46758 4957 110537555
Tuberculin test positive 48.84 13.07 26 46761 3642 110538870
Muscle spasms 48.15 13.07 29 46758 278128 110264384
Neuropathy peripheral 48.11 13.07 176 46611 179101 110363411
Infection 47.35 13.07 50 46737 362150 110180362
Sinusitis 47.20 13.07 34 46753 296654 110245858
Pain 47.07 13.07 226 46561 954729 109587783
Type 2 diabetes mellitus 46.95 13.07 9 46778 177223 110365289
Immunosuppressant drug level decreased 46.64 13.07 23 46764 2748 110539764
Stomatitis 45.63 13.07 29 46758 270213 110272299
Hepatitis cholestatic 45.30 13.07 46 46741 17520 110524992
Tuberculosis of eye 45.21 13.07 10 46777 85 110542427
Hemianopia heteronymous 45.00 13.07 10 46777 87 110542425
Hyperuricaemia 44.87 13.07 42 46745 14489 110528023
Central nervous system vasculitis 44.43 13.07 19 46768 1635 110540877
Pleural effusion 43.98 13.07 170 46617 177539 110364973
Gastrooesophageal reflux disease 43.91 13.07 11 46776 179965 110362547
Ill-defined disorder 43.65 13.07 7 46780 156846 110385666
Disseminated intravascular coagulation 43.29 13.07 69 46718 41217 110501295
Bursitis 43.27 13.07 3 46784 129915 110412597
Sleep disorder 43.24 13.07 15 46772 198629 110343883
Colitis ulcerative 42.25 13.07 98 46689 77265 110465247
Blood cholesterol increased 41.90 13.07 13 46774 184772 110357740
Diaphragmatic injury 41.64 13.07 10 46777 126 110542386
Glomerulonephritis minimal lesion 41.20 13.07 16 46771 1075 110541437
Osteoarthritis 41.14 13.07 13 46774 182610 110359902
Memory impairment 40.97 13.07 16 46771 196928 110345584
Mobility decreased 40.74 13.07 25 46762 237397 110305115
Demodicidosis 40.37 13.07 11 46776 235 110542277
Drug eruption 39.78 13.07 77 46710 53582 110488930
Adrenocortical insufficiency acute 39.03 13.07 24 46763 4416 110538096
Interferon gamma release assay positive 38.91 13.07 10 46777 169 110542343
Renal transplant failure 38.54 13.07 20 46767 2660 110539852
Bilirubin conjugated increased 38.49 13.07 27 46760 6197 110536315
Hepatic cytolysis 38.39 13.07 77 46710 54976 110487536
Sideroblastic anaemia 37.94 13.07 12 46775 437 110542075
Thalamic infarction 37.87 13.07 16 46771 1336 110541176
Mycoplasma genitalium infection 37.68 13.07 7 46780 21 110542491
Haemophagocytic lymphohistiocytosis 37.66 13.07 56 46731 31503 110511009
Folliculitis 37.65 13.07 12 46775 167641 110374871
Hyperbilirubinaemia 37.43 13.07 55 46732 30616 110511896
Pyelonephritis fungal 37.31 13.07 11 46776 315 110542197
Cachexia 37.13 13.07 36 46751 12969 110529543
Depression 36.97 13.07 48 46739 317287 110225225
Toxic epidermal necrolysis 36.79 13.07 77 46710 56650 110485862
Optic atrophy 36.79 13.07 19 46768 2502 110540010
Obesity 36.66 13.07 3 46784 113348 110429164
Malignant neoplasm progression 36.61 13.07 14 46773 174553 110367959
Splenic embolism 36.60 13.07 10 46777 216 110542296
Weight increased 36.32 13.07 77 46710 419567 110122945
Psoriatic arthropathy 36.22 13.07 19 46768 196742 110345770
Hepatomegaly 36.20 13.07 45 46742 21369 110521143
Nicotinic acid deficiency 36.17 13.07 10 46777 226 110542286
Skin disorder 36.08 13.07 65 46722 42848 110499664
Liver injury 35.68 13.07 142 46645 150271 110392241
Asthma 35.66 13.07 32 46755 250259 110292253
Anxiety 35.47 13.07 57 46730 345021 110197491
Psychotic disorder 35.23 13.07 71 46716 50866 110491646
Pericarditis 34.99 13.07 25 46762 219089 110323423
Toxic optic neuropathy 34.83 13.07 15 46772 1313 110541199
Febrile neutropenia 34.79 13.07 50 46737 316717 110225795
Ocular toxicity 34.73 13.07 15 46772 1323 110541189
Transplant rejection 34.33 13.07 47 46740 24520 110517992
Aspergillus infection 34.29 13.07 48 46739 25568 110516944
Hepatosplenomegaly 33.72 13.07 26 46761 6893 110535619
Pulmonary granuloma 33.67 13.07 18 46769 2543 110539969
Lichenoid keratosis 33.63 13.07 25 46762 6277 110536235
Pancreatitis acute 33.62 13.07 77 46710 60197 110482315
Pericardial effusion 32.92 13.07 74 46713 57143 110485369
Jarisch-Herxheimer reaction 32.76 13.07 14 46773 1203 110541309
Feeling abnormal 32.46 13.07 18 46769 180693 110361819
Substance-induced psychotic disorder 32.31 13.07 23 46764 5401 110537111
Gingivitis ulcerative 32.25 13.07 11 46776 509 110542003
Pancytopenia 32.04 13.07 174 46613 209439 110333073
Papilloma 31.83 13.07 11 46776 530 110541982
Drug ineffective 31.17 13.07 852 45935 1519688 109022824
Dizziness 31.08 13.07 171 46616 698022 109844490
Coma hepatic 31.02 13.07 13 46774 1064 110541448
Urinary tract inflammation 31.01 13.07 10 46777 388 110542124
Herpes zoster meningoencephalitis 31.01 13.07 13 46774 1065 110541447
Migraine 30.97 13.07 17 46770 171635 110370877
Oedematous kidney 30.42 13.07 9 46778 261 110542251
Musculoskeletal pain 30.39 13.07 20 46767 183003 110359509
Aplasia pure red cell 30.18 13.07 28 46759 9550 110532962
Cholestatic liver injury 30.15 13.07 25 46762 7351 110535161
Ocular icterus 30.05 13.07 23 46764 6030 110536482
Infective aneurysm 30.02 13.07 14 46773 1478 110541034
Musculoskeletal stiffness 29.92 13.07 45 46742 279777 110262735
Anaemia 29.77 13.07 358 46429 546728 109995784
Granulomatous lymphadenitis 29.65 13.07 10 46777 447 110542065
Conductive deafness 29.25 13.07 9 46778 299 110542213
Pneumocystis jirovecii pneumonia 28.88 13.07 59 46728 42676 110499836
Dermatitis exfoliative generalised 28.78 13.07 29 46758 10943 110531569
Congestive hepatopathy 28.51 13.07 21 46766 5199 110537313
Gamma-glutamyltransferase increased 28.50 13.07 73 46714 61236 110481276
Blood alkaline phosphatase increased 28.48 13.07 80 46707 70855 110471657
Thrombocytopenia 28.40 13.07 248 46539 348637 110193875
Cerebellar ataxia 28.37 13.07 15 46772 2073 110540439
Mycobacterium abscessus infection 28.24 13.07 14 46773 1692 110540820
Type III immune complex mediated reaction 27.97 13.07 12 46775 1041 110541471
Blister 27.93 13.07 33 46754 227343 110315169
Pain in extremity 27.76 13.07 109 46678 487009 110055503
Accelerated hypertension 27.67 13.07 11 46776 786 110541726
Metabolic acidosis 27.65 13.07 99 46688 99645 110442867
Urogenital infection bacterial 27.42 13.07 7 46780 115 110542397
Back pain 27.39 13.07 74 46713 370922 110171590
Intentional product use issue 27.35 13.07 39 46748 247867 110294645
Diarrhoea 27.26 13.07 330 46457 1139175 109403337
Splenomegaly 27.15 13.07 42 46745 24456 110518056
Focal dyscognitive seizures 26.88 13.07 18 46769 3831 110538681
Joint range of motion decreased 26.86 13.07 9 46778 121823 110420689
Erythema 26.83 13.07 213 46574 291234 110251278
Rheumatoid arthritis 26.74 13.07 54 46733 299559 110242953
Hypermetabolism 26.63 13.07 10 46777 613 110541899
Amnesia 26.58 13.07 6 46781 105402 110437110
Prescribed overdose 26.52 13.07 3 46784 87578 110454934
Hepatitis acute 26.37 13.07 36 46751 18730 110523782
Distributive shock 26.21 13.07 21 46766 5883 110536629
Choroiditis 25.98 13.07 13 46774 1602 110540910
Neurotoxicity 25.88 13.07 56 46731 42151 110500361
Intestinal tuberculosis 25.60 13.07 8 46779 280 110542232
HIV infection 25.52 13.07 12 46775 1291 110541221
Chromaturia 25.36 13.07 45 46742 29315 110513197
Henoch-Schonlein purpura 25.30 13.07 17 46770 3640 110538872
Splenic abscess 25.26 13.07 11 46776 989 110541523
Cholestasis 25.15 13.07 72 46715 64446 110478066
Stevens-Johnson syndrome 25.15 13.07 59 46728 46842 110495670
Injection site pain 25.03 13.07 23 46764 177899 110364613
Cerebrovascular accident 24.84 13.07 24 46763 181260 110361252
Haemolytic anaemia 24.79 13.07 37 46750 20883 110521629
Type I hypersensitivity 24.75 13.07 21 46766 6372 110536140
COVID-19 24.68 13.07 41 46746 245019 110297493
Marrow hyperplasia 24.68 13.07 13 46774 1783 110540729
Antipsychotic drug level decreased 24.60 13.07 12 46775 1400 110541112
Multiple organ dysfunction syndrome 24.58 13.07 128 46659 151582 110390930
Dermatitis exfoliative 24.44 13.07 27 46760 11320 110531192
Pulmonary sequestration 24.42 13.07 5 46782 28 110542484
Shock 24.08 13.07 63 46724 53525 110488987
Thrombosis 24.00 13.07 8 46779 108654 110433858
Extrapulmonary tuberculosis 23.96 13.07 9 46778 552 110541960
Seizure 23.95 13.07 168 46619 221017 110321495
Unmasking of previously unidentified disease 23.94 13.07 15 46772 2853 110539659
Psoas abscess 23.90 13.07 12 46775 1490 110541022
Gait inability 23.89 13.07 14 46773 136362 110406150
Central nervous system lesion 23.64 13.07 31 46756 15522 110526990
Road traffic accident 23.56 13.07 8 46779 107390 110435122
Colour blindness 23.52 13.07 9 46778 581 110541931
Product prescribing issue 23.47 13.07 28 46759 12744 110529768
Myocardial infarction 23.46 13.07 28 46759 192055 110350457
Papule 23.37 13.07 25 46762 10108 110532404
Myocarditis 23.35 13.07 44 46743 30011 110512501
Lymphadenitis 23.25 13.07 19 46768 5474 110537038
Acid fast bacilli infection 23.21 13.07 7 46780 217 110542295
Joint tuberculosis 23.06 13.07 7 46780 222 110542290
Oedematous pancreatitis 22.80 13.07 12 46775 1642 110540870
Rash morbilliform 22.68 13.07 22 46765 7929 110534583
Vitamin B1 decreased 22.66 13.07 10 46777 929 110541583
Injection site reaction 22.60 13.07 5 46782 89065 110453447
Fluid retention 22.54 13.07 6 46781 94301 110448211
Pericarditis tuberculous 22.54 13.07 6 46781 117 110542395
Skin lesion 22.49 13.07 60 46727 51571 110490941
Gastric disorder 22.48 13.07 46 46741 33311 110509201
Cytomegalovirus infection 22.44 13.07 62 46725 54382 110488130
Hypotension 22.37 13.07 130 46657 523719 110018793
Dyspnoea 22.30 13.07 332 46455 1106540 109435972
Hypoaesthesia 22.21 13.07 64 46723 314159 110228353
Nasal congestion 22.12 13.07 7 46780 98275 110444237
Maternal exposure during pregnancy 21.84 13.07 47 46740 254836 110287676
Balance disorder 21.83 13.07 11 46776 116549 110425963
Cryptococcosis 21.69 13.07 17 46770 4614 110537898
Hilar lymphadenopathy 21.66 13.07 13 46774 2289 110540223
Lung infiltration 21.60 13.07 38 46749 24590 110517922
Lymphocyte stimulation test positive 21.53 13.07 10 46777 1046 110541466
Pulmonary embolism 21.49 13.07 36 46751 214438 110328074
Grip strength decreased 21.38 13.07 4 46783 80170 110462342
Mitochondrial neurogastrointestinal encephalopathy 21.29 13.07 4 46783 13 110542499
Mycobacterium fortuitum infection 21.28 13.07 8 46779 492 110542020
Cutaneous tuberculosis 21.27 13.07 7 46780 290 110542222
Ototoxicity 21.18 13.07 16 46771 4115 110538397
Brain oedema 21.09 13.07 43 46744 31055 110511457
Palpable purpura 21.08 13.07 8 46779 505 110542007
Blood pressure increased 21.03 13.07 49 46738 258324 110284188
Chest pain 20.94 13.07 85 46702 376290 110166222
Bradycardia 20.83 13.07 21 46766 155496 110387016
Mastitis bacterial 20.82 13.07 5 46782 63 110542449
Lymph node abscess 20.82 13.07 5 46782 63 110542449
Pseudomembranous colitis 20.75 13.07 19 46768 6372 110536140
Epistaxis 20.64 13.07 15 46772 130357 110412155
Paraesthesia 20.52 13.07 55 46732 276466 110266046
Pulmonary tuberculoma 20.31 13.07 3 46784 0 110542512
Ascites 19.94 13.07 85 46702 92723 110449789
Lymphopenia 19.89 13.07 49 46738 40121 110502391
Necrosis 19.33 13.07 24 46763 11382 110531130
Hereditary optic atrophy 19.26 13.07 5 46782 88 110542424
Hepatitis B core antibody positive 19.13 13.07 8 46779 651 110541861
Frequent bowel movements 19.06 13.07 70 46717 71320 110471192
Subacute hepatic failure 18.65 13.07 6 46781 231 110542281
Delayed graft function 18.60 13.07 15 46772 4242 110538270
Spermatozoa progressive motility abnormal 18.53 13.07 4 46783 30 110542482
Enterovesical fistula 18.51 13.07 10 46777 1443 110541069
Tuberculosis of genitourinary system 18.43 13.07 5 46782 105 110542407
Tuberculoid leprosy 18.13 13.07 5 46782 112 110542400
Prescribed underdose 17.93 13.07 3 46784 65171 110477341
Hypercholesterolaemia 17.89 13.07 8 46779 90829 110451683
Testicular mass 17.80 13.07 5 46782 120 110542392
Lower limb fracture 17.62 13.07 5 46782 75343 110467169
Hypersensitivity vasculitis 17.58 13.07 18 46769 6919 110535593
Hyperinsulinaemia 17.52 13.07 6 46781 281 110542231
Sedation 17.50 13.07 4 46783 69679 110472833
Transient ischaemic attack 17.48 13.07 3 46784 63979 110478533
Chronic allograft nephropathy 17.44 13.07 11 46776 2115 110540397
General physical health deterioration 17.38 13.07 107 46680 425188 110117324
Central venous pressure increased 17.17 13.07 5 46782 137 110542375
Nephrotic syndrome 17.16 13.07 25 46762 13806 110528706
Inappropriate schedule of product administration 17.07 13.07 38 46749 203599 110338913
Haematochezia 17.04 13.07 95 46692 115429 110427083
Genitourinary tract infection 17.03 13.07 6 46781 306 110542206
Adverse drug reaction 16.90 13.07 12 46775 105547 110436965
Polyneuropathy 16.87 13.07 40 46747 31972 110510540
Medication error 16.84 13.07 12 46775 105354 110437158
Infectious pleural effusion 16.78 13.07 15 46772 4876 110537636
Wrong technique in product usage process 16.72 13.07 8 46779 87340 110455172
Chronic obstructive pulmonary disease 16.71 13.07 13 46774 109145 110433367
Acute respiratory distress syndrome 16.66 13.07 55 46732 53143 110489369
Intentional product misuse 16.63 13.07 19 46768 132885 110409627
Adverse event 16.61 13.07 13 46774 108796 110433716
Disseminated Bacillus Calmette-Guerin infection 16.53 13.07 6 46781 334 110542178
Coronary artery disease 16.32 13.07 5 46782 71685 110470827
Hepatic haematoma 16.21 13.07 8 46779 957 110541555
Tuberculid 16.15 13.07 3 46784 9 110542503
Dysphagia 16.12 13.07 25 46762 153575 110388937
Macule 16.05 13.07 13 46774 3700 110538812
Oesophageal candidiasis 16.01 13.07 22 46765 11512 110531000
CD4 lymphocytes 15.91 13.07 3 46784 10 110542502
Pancreatitis 15.90 13.07 80 46707 93453 110449059
Condition aggravated 15.88 13.07 415 46372 734421 109808091
Leprosy 15.84 13.07 5 46782 181 110542331
Drug level below therapeutic 15.81 13.07 22 46765 11651 110530861
Meningitis 15.77 13.07 22 46765 11680 110530832
Interstitial lung disease 15.76 13.07 107 46680 139227 110403285
Cerebral infarction 15.71 13.07 53 46734 51785 110490727
Arachnoiditis 15.62 13.07 8 46779 1036 110541476
Live birth 15.55 13.07 5 46782 69479 110473033
Erythrodermic psoriasis 15.50 13.07 10 46777 2000 110540512
Incorrect route of product administration 15.46 13.07 4 46783 64057 110478455
Mycobacterium kansasii infection 15.44 13.07 6 46781 404 110542108
Urticaria 15.33 13.07 76 46711 318781 110223731
Hepatic enzyme increased 15.30 13.07 205 46582 320687 110221825
Spleen palpable 15.29 13.07 3 46784 13 110542499
Completed suicide 15.26 13.07 52 46735 242329 110300183
Loss of personal independence in daily activities 15.19 13.07 25 46762 149995 110392517
Pleurisy 15.18 13.07 22 46765 12094 110530418
Implant site infection 15.09 13.07 10 46777 2093 110540419
Drug metabolising enzyme increased 14.94 13.07 3 46784 15 110542497
Femoral artery aneurysm 14.90 13.07 5 46782 220 110542292
Confusional state 14.76 13.07 127 46660 468553 110073959
Lung consolidation 14.57 13.07 20 46767 10456 110532056
Rebound effect 14.51 13.07 24 46763 14782 110527730
Respiratory failure 14.47 13.07 147 46640 215185 110327327
Optic disc hyperaemia 14.34 13.07 3 46784 19 110542493
Prothrombin time prolonged 14.32 13.07 26 46761 17235 110525277
Type IV hypersensitivity reaction 14.12 13.07 15 46772 6018 110536494
Renal atrophy 14.09 13.07 10 46777 2336 110540176
Disseminated mycobacterium avium complex infection 14.08 13.07 6 46781 512 110542000
Knee arthroplasty 13.96 13.07 5 46782 64943 110477569
Visual pathway disorder 13.79 13.07 4 46783 108 110542404
Gait disturbance 13.55 13.07 66 46721 278142 110264370
Lymphadenopathy mediastinal 13.49 13.07 14 46773 5470 110537042
Ear pain 13.48 13.07 3 46784 53223 110489289
Psychiatric symptom 13.44 13.07 18 46769 9195 110533317
Methylobacterium infection 13.41 13.07 3 46784 27 110542485
Serotonin syndrome 13.34 13.07 55 46732 59098 110483414
Altered state of consciousness 13.33 13.07 54 46733 57572 110484940
Subcutaneous abscess 13.28 13.07 18 46769 9299 110533213
Oligohydramnios 13.22 13.07 12 46775 3982 110538530
Ear infection 13.20 13.07 5 46782 62727 110479785
Drug level fluctuating 13.15 13.07 7 46780 980 110541532
Proteinuria 13.10 13.07 42 46745 39976 110502536
Nocardiosis 13.09 13.07 16 46771 7470 110535042

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J04AC01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Hydrazides
ATC J04AC51 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Hydrazides
ATC J04AM01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC J04AM02 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC J04AM03 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC J04AM04 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC J04AM05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC J04AM06 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC J04AM07 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC J04AM08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC J04AM09 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
ATC J04AM12 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
FDA EPC N0000175483 Antimycobacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000995 Antitubercular Agents
MeSH PA D054872 Fatty Acid Synthesis Inhibitors
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:49201 anti-ulcer drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:88188 drug allergen

Related Drugs by ATC class:

J04AC Hydrazides 1 drug
ftivazide
J04AM Combinations of drugs for treatment of tuberculosis 11 drugs
ethambutollevofloxacinlomefloxacinprotionamidepyrazinamiderifabutinrifampicinstreptomycinsulfamethoxazolethioacetazonetrimethoprim

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Inactive tuberculosis indication 11999007
Acute tuberculosis indication 25629007
Pulmonary tuberculosis indication 154283005 DOID:2957
Tuberculosis of meninges off-label use 58437007
Atypical mycobacterial infection off-label use 111812000
Nutritional disorder contraindication 2492009 DOID:374
Alcoholism contraindication 7200002
Jaundice contraindication 18165001
Acute hepatitis contraindication 37871000
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Diabetes mellitus contraindication 73211009 DOID:9351
Gout contraindication 90560007 DOID:13189
Anemia due to enzyme deficiency contraindication 111577008
Acute hepatic failure contraindication 197270009
Disease of liver contraindication 235856003 DOID:409
Diabetic - poor control contraindication 268519009
Peripheral nerve disease contraindication 302226006
Porphyria contraindication 418470004
Diabetic peripheral neuropathy contraindication 424736006
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005
Prolonged-Severe Nausea and Vomiting contraindication
Chronic Hepatic Disease contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.98 acidic
pKa2 3.79 Basic
pKa3 1.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cytochrome P450 3A4 Enzyme IC50 5.31 WOMBAT-PK
Myeloperoxidase Enzyme IC50 5.33 CHEMBL
Cytochrome P450 3A5 Enzyme IC50 4.96 WOMBAT-PK
Enoyl-[acyl-carrier-protein] reductase [NADH] Enzyme INHIBITOR IC50 5.08 CHEMBL CHEMBL
Catalase-peroxidase Enzyme WOMBAT-PK
Dihydrofolate reductase Enzyme Ki 9 CHEMBL

External reference:

IDSource
4017505 VUID
N0000145890 NUI
D00346 KEGG_DRUG
4017505 VANDF
C0022209 UMLSCUI
CHEBI:6030 CHEBI
ISZ PDB_CHEM_ID
CHEMBL64 ChEMBL_ID
3767 PUBCHEM_CID
DB00951 DRUGBANK_ID
D007538 MESH_DESCRIPTOR_UI
4188 INN_ID
12761 IUPHAR_LIGAND_ID
V83O1VOZ8L UNII
6038 RXNORM
2955 MMSL
4929 MMSL
d00101 MMSL
002844 NDDF
387472004 SNOMEDCT_US
81335000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 0440-1655 TABLET 300 mg ORAL ANDA 24 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 0440-7655 TABLET 300 mg ORAL ANDA 22 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 0555-0066 TABLET 100 mg ORAL ANDA 24 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 0555-0071 TABLET 300 mg ORAL ANDA 24 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 0781-3056 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 22 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 10135-584 TABLET 300 mg ORAL ANDA 22 sections
isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 10135-804 TABLET 100 mg ORAL ANDA 23 sections
isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 10135-805 TABLET 300 mg ORAL ANDA 23 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 10544-087 TABLET 300 mg ORAL ANDA 23 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 10544-121 TABLET 300 mg ORAL ANDA 23 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 10544-218 TABLET 300 mg ORAL ANDA 22 sections
ISONIAZID HUMAN PRESCRIPTION DRUG LABEL 1 16590-984 TABLET 300 mg ORAL ANDA 13 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 21695-627 TABLET 300 mg ORAL ANDA 22 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 46287-009 SOLUTION 50 mg ORAL ANDA 24 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 50090-0370 TABLET 300 mg ORAL ANDA 23 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 50090-0410 TABLET 100 mg ORAL ANDA 23 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 50090-1490 SOLUTION 50 mg ORAL ANDA 23 sections
isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 50090-7660 TABLET 300 mg ORAL ANDA 23 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 51079-083 TABLET 300 mg ORAL ANDA 24 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 51655-391 TABLET 300 mg ORAL ANDA 10 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 52959-145 TABLET 300 mg ORAL ANDA 22 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 53002-2920 TABLET 300 mg ORAL ANDA 23 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 53808-1041 TABLET 300 mg ORAL ANDA 23 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 54868-2304 TABLET 100 mg ORAL ANDA 24 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 54868-2416 TABLET 300 mg ORAL ANDA 24 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 55695-027 TABLET 100 mg ORAL ANDA 24 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 55695-031 SOLUTION 50 mg ORAL ANDA 25 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 55695-033 TABLET 300 mg ORAL ANDA 24 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 60687-553 TABLET 300 mg ORAL ANDA 22 sections
Isoniazid HUMAN PRESCRIPTION DRUG LABEL 1 61748-013 TABLET 300 mg ORAL ANDA 23 sections