Stem definition | Drug id | CAS RN |
---|---|---|
1497 | 54-85-3 |
Dose | Unit | Route |
---|---|---|
0.30 | g | O |
0.30 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 140 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 7 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 72.92 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 80 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.82 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 7.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Sept. 29, 1952 | FDA | SANDOZ |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug reaction with eosinophilia and systemic symptoms | 641.63 | 13.88 | 285 | 21411 | 33551 | 63433775 |
Drug-induced liver injury | 498.99 | 13.88 | 253 | 21443 | 39969 | 63427357 |
Paradoxical drug reaction | 463.63 | 13.88 | 131 | 21565 | 4021 | 63463305 |
Acute hepatic failure | 342.72 | 13.88 | 153 | 21543 | 18174 | 63449152 |
Drug resistance | 277.63 | 13.88 | 142 | 21554 | 22791 | 63444535 |
Hepatitis | 255.99 | 13.88 | 163 | 21533 | 39625 | 63427701 |
Hepatotoxicity | 238.92 | 13.88 | 152 | 21544 | 36889 | 63430437 |
Tuberculoma of central nervous system | 222.41 | 13.88 | 45 | 21651 | 302 | 63467024 |
Tuberculosis | 217.26 | 13.88 | 96 | 21600 | 11115 | 63456211 |
Jaundice | 211.26 | 13.88 | 129 | 21567 | 29122 | 63438204 |
Hepatic encephalopathy | 194.41 | 13.88 | 89 | 21607 | 11193 | 63456133 |
Immune reconstitution inflammatory syndrome | 192.54 | 13.88 | 74 | 21622 | 6010 | 63461316 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 178.97 | 13.88 | 38 | 21658 | 332 | 63466994 |
Pulmonary tuberculosis | 164.91 | 13.88 | 61 | 21635 | 4456 | 63462870 |
Drug interaction | 161.19 | 13.88 | 284 | 21412 | 228847 | 63238479 |
Loss of employment | 159.70 | 13.88 | 50 | 21646 | 2194 | 63465132 |
Pyrexia | 113.14 | 13.88 | 385 | 21311 | 470093 | 62997233 |
Hepatic failure | 112.44 | 13.88 | 95 | 21601 | 35561 | 63431765 |
Exposure during pregnancy | 99.28 | 13.88 | 185 | 21511 | 155362 | 63311964 |
Encephalopathy | 98.04 | 13.88 | 91 | 21605 | 38529 | 63428797 |
Hepatic steatosis | 97.66 | 13.88 | 80 | 21616 | 28689 | 63438637 |
Hepatic function abnormal | 97.17 | 13.88 | 89 | 21607 | 37053 | 63430273 |
Disseminated tuberculosis | 94.75 | 13.88 | 36 | 21660 | 2831 | 63464495 |
Cerebellar ataxia | 94.09 | 13.88 | 27 | 21669 | 875 | 63466451 |
Transaminases increased | 83.68 | 13.88 | 76 | 21620 | 31291 | 63436035 |
Liver injury | 81.60 | 13.88 | 102 | 21594 | 60418 | 63406908 |
Alanine aminotransferase increased | 78.50 | 13.88 | 133 | 21563 | 103637 | 63363689 |
Myocarditis | 78.27 | 13.88 | 47 | 21649 | 10278 | 63457048 |
Aspartate aminotransferase increased | 76.78 | 13.88 | 122 | 21574 | 90155 | 63377171 |
Pancreatitis haemorrhagic | 74.17 | 13.88 | 20 | 21676 | 513 | 63466813 |
Lymphadenopathy | 74.15 | 13.88 | 78 | 21618 | 38380 | 63428946 |
Eosinophilia | 72.49 | 13.88 | 61 | 21635 | 22695 | 63444631 |
Gastric disorder | 67.12 | 13.88 | 73 | 21623 | 37296 | 63430030 |
Liver disorder | 66.87 | 13.88 | 87 | 21609 | 53600 | 63413726 |
Lymph node tuberculosis | 66.16 | 13.88 | 20 | 21676 | 779 | 63466547 |
Fatigue | 65.69 | 13.88 | 128 | 21568 | 887900 | 62579426 |
Pain | 63.63 | 13.88 | 97 | 21599 | 740531 | 62726795 |
Pneumocystis jirovecii pneumonia | 59.43 | 13.88 | 48 | 21648 | 16866 | 63450460 |
Multiple organ dysfunction syndrome | 58.62 | 13.88 | 84 | 21612 | 56668 | 63410658 |
Congestive hepatopathy | 56.36 | 13.88 | 25 | 21671 | 2917 | 63464409 |
Generalised tonic-clonic seizure | 54.42 | 13.88 | 58 | 21638 | 28958 | 63438368 |
Meningitis tuberculous | 54.11 | 13.88 | 16 | 21680 | 577 | 63466749 |
Face oedema | 53.95 | 13.88 | 49 | 21647 | 20163 | 63447163 |
Tuberculosis gastrointestinal | 51.92 | 13.88 | 14 | 21682 | 359 | 63466967 |
Distributive shock | 51.67 | 13.88 | 19 | 21677 | 1364 | 63465962 |
Arthropathy | 49.53 | 13.88 | 10 | 21686 | 234782 | 63232544 |
Glossodynia | 49.16 | 13.88 | 3 | 21693 | 178873 | 63288453 |
Tuberculin test positive | 49.11 | 13.88 | 24 | 21672 | 3487 | 63463839 |
Hepatitis toxic | 47.81 | 13.88 | 23 | 21673 | 3230 | 63464096 |
Mycobacterium tuberculosis complex test positive | 45.94 | 13.88 | 20 | 21676 | 2231 | 63465095 |
Hand deformity | 42.85 | 13.88 | 3 | 21693 | 159454 | 63307872 |
Alopecia | 42.48 | 13.88 | 32 | 21664 | 337504 | 63129822 |
Liver transplant | 42.39 | 13.88 | 19 | 21677 | 2272 | 63465054 |
Glomerulonephritis minimal lesion | 42.31 | 13.88 | 11 | 21685 | 244 | 63467082 |
Oedematous pancreatitis | 41.56 | 13.88 | 13 | 21683 | 568 | 63466758 |
Wound | 41.31 | 13.88 | 4 | 21692 | 163259 | 63304067 |
Hepatitis fulminant | 40.59 | 13.88 | 21 | 21675 | 3443 | 63463883 |
Latent tuberculosis | 39.90 | 13.88 | 19 | 21677 | 2608 | 63464718 |
Oedematous kidney | 39.56 | 13.88 | 9 | 21687 | 111 | 63467215 |
Synovitis | 39.33 | 13.88 | 8 | 21688 | 186910 | 63280416 |
Swelling | 38.82 | 13.88 | 23 | 21673 | 275355 | 63191971 |
Hepatocellular injury | 38.25 | 13.88 | 47 | 21649 | 27334 | 63439992 |
Aspergillus infection | 37.30 | 13.88 | 27 | 21669 | 8066 | 63459260 |
Pleural effusion | 36.46 | 13.88 | 91 | 21605 | 93119 | 63374207 |
Hepatic necrosis | 35.79 | 13.88 | 23 | 21673 | 5664 | 63461662 |
Hepatic haematoma | 35.59 | 13.88 | 11 | 21685 | 462 | 63466864 |
Product dose omission issue | 35.30 | 13.88 | 18 | 21678 | 234295 | 63233031 |
Focal dyscognitive seizures | 35.06 | 13.88 | 18 | 21678 | 2903 | 63464423 |
Coagulopathy | 34.92 | 13.88 | 39 | 21657 | 20505 | 63446821 |
Cardiac failure | 34.84 | 13.88 | 87 | 21609 | 89055 | 63378271 |
Hepatosplenomegaly | 33.98 | 13.88 | 17 | 21679 | 2597 | 63464729 |
Disseminated intravascular coagulation | 33.82 | 13.88 | 37 | 21659 | 19014 | 63448312 |
Mycoplasma genitalium infection | 33.58 | 13.88 | 6 | 21690 | 18 | 63467308 |
Discomfort | 33.52 | 13.88 | 8 | 21688 | 167366 | 63299960 |
Serotonin syndrome | 33.42 | 13.88 | 45 | 21651 | 28637 | 63438689 |
Systemic lupus erythematosus | 33.06 | 13.88 | 15 | 21681 | 208903 | 63258423 |
Rash maculo-papular | 32.62 | 13.88 | 47 | 21649 | 31849 | 63435477 |
Sinusitis | 31.83 | 13.88 | 19 | 21677 | 226634 | 63240692 |
Drug level decreased | 31.10 | 13.88 | 24 | 21672 | 7895 | 63459431 |
Treatment noncompliance | 31.09 | 13.88 | 50 | 21646 | 37275 | 63430051 |
Jarisch-Herxheimer reaction | 29.35 | 13.88 | 9 | 21687 | 368 | 63466958 |
Hemianopia heteronymous | 29.19 | 13.88 | 6 | 21690 | 44 | 63467282 |
Joint swelling | 28.90 | 13.88 | 42 | 21654 | 327624 | 63139702 |
Fall | 28.46 | 13.88 | 57 | 21639 | 392277 | 63075049 |
Bovine tuberculosis | 28.40 | 13.88 | 6 | 21690 | 51 | 63467275 |
Cholestatic liver injury | 28.23 | 13.88 | 15 | 21681 | 2595 | 63464731 |
Tuberculous pleurisy | 28.20 | 13.88 | 9 | 21687 | 420 | 63466906 |
Hypertransaminasaemia | 28.09 | 13.88 | 21 | 21675 | 6588 | 63460738 |
Multiple-drug resistance | 27.90 | 13.88 | 19 | 21677 | 5151 | 63462175 |
Peritoneal tuberculosis | 26.92 | 13.88 | 9 | 21687 | 487 | 63466839 |
Pathogen resistance | 26.46 | 13.88 | 20 | 21676 | 6378 | 63460948 |
Gamma-glutamyltransferase increased | 26.20 | 13.88 | 44 | 21652 | 33987 | 63433339 |
Ocular icterus | 26.05 | 13.88 | 16 | 21680 | 3640 | 63463686 |
Pericardial effusion | 26.05 | 13.88 | 41 | 21655 | 30017 | 63437309 |
Cardiac failure congestive | 25.98 | 13.88 | 80 | 21616 | 92353 | 63374973 |
Liver function test abnormal | 25.46 | 13.88 | 53 | 21643 | 48128 | 63419198 |
Hepatitis B core antibody positive | 25.10 | 13.88 | 7 | 21689 | 204 | 63467122 |
Immune system disorder | 24.61 | 13.88 | 23 | 21673 | 9811 | 63457515 |
Abdominal pain upper | 23.91 | 13.88 | 136 | 21560 | 206308 | 63261018 |
Seizure | 23.74 | 13.88 | 99 | 21597 | 132535 | 63334791 |
Interstitial lung disease | 23.74 | 13.88 | 60 | 21636 | 61848 | 63405478 |
Pancreatitis acute | 23.46 | 13.88 | 37 | 21659 | 27129 | 63440197 |
Contusion | 23.38 | 13.88 | 11 | 21685 | 150033 | 63317293 |
Acute respiratory distress syndrome | 23.07 | 13.88 | 34 | 21662 | 23500 | 63443826 |
Microcytic anaemia | 21.90 | 13.88 | 14 | 21682 | 3415 | 63463911 |
Mastitis bacterial | 21.88 | 13.88 | 5 | 21691 | 63 | 63467263 |
Neurotoxicity | 21.87 | 13.88 | 28 | 21668 | 16962 | 63450364 |
Bilirubin conjugated increased | 21.73 | 13.88 | 13 | 21683 | 2821 | 63464505 |
Trichophytosis | 21.67 | 13.88 | 5 | 21691 | 66 | 63467260 |
Helicobacter infection | 21.65 | 13.88 | 3 | 21693 | 92782 | 63374544 |
Peripheral swelling | 21.61 | 13.88 | 36 | 21660 | 265906 | 63201420 |
Cytomegalovirus infection | 21.60 | 13.88 | 31 | 21665 | 20921 | 63446405 |
Maternal exposure during breast feeding | 21.51 | 13.88 | 15 | 21681 | 4226 | 63463100 |
Toxic optic neuropathy | 21.07 | 13.88 | 6 | 21690 | 189 | 63467137 |
Blood bilirubin increased | 20.97 | 13.88 | 42 | 21654 | 37098 | 63430228 |
Pericarditis tuberculous | 20.94 | 13.88 | 4 | 21692 | 19 | 63467307 |
Liver transplant rejection | 20.64 | 13.88 | 10 | 21686 | 1425 | 63465901 |
Pseudomembranous colitis | 20.61 | 13.88 | 13 | 21683 | 3099 | 63464227 |
Electrocardiogram ST segment elevation | 20.18 | 13.88 | 14 | 21682 | 3913 | 63463413 |
Blood beta-D-glucan increased | 20.17 | 13.88 | 6 | 21690 | 221 | 63467105 |
Pericarditis | 19.96 | 13.88 | 10 | 21686 | 131569 | 63335757 |
Intentional overdose | 19.75 | 13.88 | 63 | 21633 | 74089 | 63393237 |
Infectious pleural effusion | 19.71 | 13.88 | 10 | 21686 | 1573 | 63465753 |
Oral candidiasis | 19.62 | 13.88 | 31 | 21665 | 22767 | 63444559 |
Infection | 19.58 | 13.88 | 30 | 21666 | 229143 | 63238183 |
Hyperinsulinaemia | 19.40 | 13.88 | 5 | 21691 | 107 | 63467219 |
Stillbirth | 19.27 | 13.88 | 17 | 21679 | 6733 | 63460593 |
Hypersensitivity | 19.15 | 13.88 | 45 | 21651 | 292640 | 63174686 |
Central venous pressure increased | 19.14 | 13.88 | 5 | 21691 | 113 | 63467213 |
Hepatic cyst | 18.90 | 13.88 | 15 | 21681 | 5139 | 63462187 |
Joint tuberculosis | 18.82 | 13.88 | 5 | 21691 | 121 | 63467205 |
Mobility decreased | 18.69 | 13.88 | 9 | 21687 | 121150 | 63346176 |
Lower respiratory tract infection | 18.69 | 13.88 | 11 | 21685 | 132296 | 63335030 |
Cytomegalovirus chorioretinitis | 18.54 | 13.88 | 10 | 21686 | 1783 | 63465543 |
Pneumonia lipoid | 18.44 | 13.88 | 5 | 21691 | 131 | 63467195 |
Anxiety | 18.09 | 13.88 | 29 | 21667 | 217512 | 63249814 |
Status epilepticus | 17.89 | 13.88 | 24 | 21672 | 15209 | 63452117 |
Nephrotic syndrome | 17.86 | 13.88 | 15 | 21681 | 5561 | 63461765 |
Optic neuritis | 17.86 | 13.88 | 18 | 21678 | 8417 | 63458909 |
Fibromyalgia | 17.85 | 13.88 | 3 | 21693 | 80417 | 63386909 |
Substance-induced psychotic disorder | 17.75 | 13.88 | 10 | 21686 | 1941 | 63465385 |
Shock | 17.61 | 13.88 | 30 | 21666 | 23433 | 63443893 |
Vaginal flatulence | 17.53 | 13.88 | 12 | 21684 | 3281 | 63464045 |
Feeling abnormal | 17.47 | 13.88 | 15 | 21681 | 148377 | 63318949 |
Granuloma | 17.43 | 13.88 | 15 | 21681 | 5746 | 63461580 |
Interferon gamma release assay positive | 17.39 | 13.88 | 4 | 21692 | 52 | 63467274 |
Optic neuropathy | 17.37 | 13.88 | 10 | 21686 | 2022 | 63465304 |
Memory impairment | 17.26 | 13.88 | 7 | 21689 | 104251 | 63363075 |
Encephalitis | 17.09 | 13.88 | 18 | 21678 | 8862 | 63458464 |
AIDS related complication | 17.05 | 13.88 | 3 | 21693 | 8 | 63467318 |
Death | 17.04 | 13.88 | 68 | 21628 | 374313 | 63093013 |
Intraventricular haemorrhage neonatal | 17.03 | 13.88 | 5 | 21691 | 176 | 63467150 |
Drug level increased | 16.98 | 13.88 | 29 | 21667 | 22707 | 63444619 |
Muscle spasms | 16.95 | 13.88 | 17 | 21679 | 156133 | 63311193 |
Impaired healing | 16.79 | 13.88 | 7 | 21689 | 102535 | 63364791 |
Cerebrovascular accident | 16.70 | 13.88 | 8 | 21688 | 108016 | 63359310 |
Vaginal discharge | 16.56 | 13.88 | 18 | 21678 | 9180 | 63458146 |
Cardiac arrest | 16.49 | 13.88 | 69 | 21627 | 92476 | 63374850 |
Nicotinic acid deficiency | 16.39 | 13.88 | 4 | 21692 | 68 | 63467258 |
Lupus-like syndrome | 16.31 | 13.88 | 23 | 21673 | 15272 | 63452054 |
Renal transplant failure | 16.30 | 13.88 | 7 | 21689 | 755 | 63466571 |
Ill-defined disorder | 16.18 | 13.88 | 4 | 21692 | 81751 | 63385575 |
Ascites | 16.16 | 13.88 | 40 | 21656 | 40688 | 63426638 |
Acid fast bacilli infection | 15.83 | 13.88 | 4 | 21692 | 79 | 63467247 |
Insomnia | 15.81 | 13.88 | 31 | 21665 | 215221 | 63252105 |
Organising pneumonia | 15.40 | 13.88 | 14 | 21682 | 5762 | 63461564 |
Hospitalisation | 15.29 | 13.88 | 5 | 21691 | 85076 | 63382250 |
Lymphadenitis | 15.26 | 13.88 | 11 | 21685 | 3264 | 63464062 |
Nasopharyngitis | 15.14 | 13.88 | 41 | 21655 | 254216 | 63213110 |
Rash morbilliform | 15.11 | 13.88 | 11 | 21685 | 3314 | 63464012 |
Dry mouth | 15.04 | 13.88 | 4 | 21692 | 77859 | 63389467 |
Liver palpable | 14.98 | 13.88 | 3 | 21693 | 19 | 63467307 |
Thalassaemia | 14.71 | 13.88 | 4 | 21692 | 106 | 63467220 |
Metabolic acidosis | 14.56 | 13.88 | 41 | 21655 | 45028 | 63422298 |
Respiratory failure | 14.45 | 13.88 | 71 | 21625 | 101787 | 63365539 |
Hydrocephalus | 14.44 | 13.88 | 13 | 21683 | 5287 | 63462039 |
Hepatomegaly | 14.38 | 13.88 | 19 | 21677 | 11870 | 63455456 |
Congenital skin dimples | 14.30 | 13.88 | 4 | 21692 | 118 | 63467208 |
Lymph node abscess | 14.25 | 13.88 | 3 | 21693 | 25 | 63467301 |
Transplant rejection | 14.24 | 13.88 | 18 | 21678 | 10762 | 63456564 |
Aplasia pure red cell | 14.23 | 13.88 | 12 | 21684 | 4475 | 63462851 |
Antipsychotic drug level above therapeutic | 14.20 | 13.88 | 7 | 21689 | 1036 | 63466290 |
C-reactive protein increased | 14.14 | 13.88 | 67 | 21629 | 94640 | 63372686 |
Methylobacterium infection | 14.05 | 13.88 | 3 | 21693 | 27 | 63467299 |
Computerised tomogram abnormal | 14.03 | 13.88 | 9 | 21687 | 2208 | 63465118 |
Back pain | 13.99 | 13.88 | 45 | 21651 | 264100 | 63203226 |
Pain in extremity | 13.97 | 13.88 | 62 | 21634 | 331424 | 63135902 |
Dysdiadochokinesis | 13.96 | 13.88 | 4 | 21692 | 129 | 63467197 |
Haemodilution | 13.96 | 13.88 | 4 | 21692 | 129 | 63467197 |
Paraparesis | 13.92 | 13.88 | 9 | 21687 | 2239 | 63465087 |
Arachnoiditis | 13.90 | 13.88 | 5 | 21691 | 337 | 63466989 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Paradoxical drug reaction | 865.35 | 14.66 | 229 | 20136 | 3122 | 34933444 |
Drug-induced liver injury | 503.82 | 14.66 | 272 | 20093 | 28560 | 34908006 |
Immune reconstitution inflammatory syndrome | 456.54 | 14.66 | 177 | 20188 | 8582 | 34927984 |
Drug reaction with eosinophilia and systemic symptoms | 391.29 | 14.66 | 242 | 20123 | 32770 | 34903796 |
Hepatotoxicity | 356.55 | 14.66 | 196 | 20169 | 21289 | 34915277 |
Jaundice | 294.70 | 14.66 | 200 | 20165 | 31682 | 34904884 |
Drug resistance | 286.79 | 14.66 | 182 | 20183 | 25745 | 34910821 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 254.48 | 14.66 | 58 | 20307 | 400 | 34936166 |
Tuberculosis | 229.18 | 14.66 | 108 | 20257 | 8469 | 34928097 |
Tuberculoma of central nervous system | 188.21 | 14.66 | 41 | 20324 | 223 | 34936343 |
Hepatitis | 185.94 | 14.66 | 135 | 20230 | 23769 | 34912797 |
Pulmonary tuberculosis | 178.62 | 14.66 | 76 | 20289 | 4678 | 34931888 |
Drug interaction | 112.49 | 14.66 | 337 | 20028 | 225609 | 34710957 |
Pyrexia | 94.25 | 14.66 | 413 | 19952 | 332600 | 34603966 |
Immune system disorder | 91.23 | 14.66 | 49 | 20316 | 5066 | 34931500 |
Meningitis tuberculous | 87.21 | 14.66 | 27 | 20338 | 658 | 34935908 |
Disseminated tuberculosis | 81.99 | 14.66 | 35 | 20330 | 2170 | 34934396 |
Hydrocephalus | 81.94 | 14.66 | 46 | 20319 | 5186 | 34931380 |
Acute hepatic failure | 77.85 | 14.66 | 65 | 20300 | 14009 | 34922557 |
Alanine aminotransferase increased | 77.06 | 14.66 | 155 | 20210 | 80660 | 34855906 |
Hepatic function abnormal | 75.34 | 14.66 | 110 | 20255 | 44253 | 34892313 |
Death | 70.60 | 14.66 | 77 | 20288 | 397972 | 34538594 |
Granuloma | 69.01 | 14.66 | 35 | 20330 | 3216 | 34933350 |
Optic neuritis | 68.72 | 14.66 | 36 | 20329 | 3538 | 34933028 |
Liver function test abnormal | 67.80 | 14.66 | 87 | 20278 | 30987 | 34905579 |
Tuberculosis of central nervous system | 67.25 | 14.66 | 17 | 20348 | 190 | 34936376 |
Drug level decreased | 67.15 | 14.66 | 47 | 20318 | 7799 | 34928767 |
Hepatic enzyme increased | 65.05 | 14.66 | 96 | 20269 | 38984 | 34897582 |
Hepatitis toxic | 61.68 | 14.66 | 29 | 20336 | 2258 | 34934308 |
Lymphadenopathy | 57.91 | 14.66 | 77 | 20288 | 28386 | 34908180 |
Lymph node tuberculosis | 57.81 | 14.66 | 18 | 20347 | 447 | 34936119 |
Mycobacterial infection | 57.62 | 14.66 | 28 | 20337 | 2346 | 34934220 |
Tubulointerstitial nephritis | 57.48 | 14.66 | 66 | 20299 | 20958 | 34915608 |
Optic neuropathy | 56.36 | 14.66 | 26 | 20339 | 1939 | 34934627 |
Hepatic failure | 54.85 | 14.66 | 83 | 20282 | 34448 | 34902118 |
Aspartate aminotransferase increased | 54.15 | 14.66 | 121 | 20244 | 67662 | 34868904 |
Fall | 53.04 | 14.66 | 26 | 20339 | 202859 | 34733707 |
Transaminases increased | 50.67 | 14.66 | 70 | 20295 | 26753 | 34909813 |
Tuberculous pleurisy | 48.16 | 14.66 | 15 | 20350 | 373 | 34936193 |
Tuberculosis of eye | 48.03 | 14.66 | 10 | 20355 | 42 | 34936524 |
Bone tuberculosis | 47.45 | 14.66 | 15 | 20350 | 392 | 34936174 |
Skin disorder | 46.56 | 14.66 | 48 | 20317 | 13507 | 34923059 |
Tuberculosis gastrointestinal | 45.85 | 14.66 | 13 | 20352 | 231 | 34936335 |
Granulomatous liver disease | 45.10 | 14.66 | 16 | 20349 | 601 | 34935965 |
Pyelonephritis fungal | 43.49 | 14.66 | 10 | 20355 | 72 | 34936494 |
Latent tuberculosis | 42.13 | 14.66 | 19 | 20346 | 1344 | 34935222 |
Thalamic infarction | 41.42 | 14.66 | 16 | 20349 | 765 | 34935801 |
Liver disorder | 41.06 | 14.66 | 71 | 20294 | 32926 | 34903640 |
Hepatitis fulminant | 40.35 | 14.66 | 27 | 20338 | 4163 | 34932403 |
Complications of transplanted kidney | 40.35 | 14.66 | 28 | 20337 | 4581 | 34931985 |
Central nervous system vasculitis | 40.27 | 14.66 | 14 | 20351 | 495 | 34936071 |
Multiple-drug resistance | 39.36 | 14.66 | 29 | 20336 | 5210 | 34931356 |
Toxic epidermal necrolysis | 38.66 | 14.66 | 55 | 20310 | 21591 | 34914975 |
Diaphragmatic injury | 38.46 | 14.66 | 10 | 20355 | 126 | 34936440 |
Demodicidosis | 38.06 | 14.66 | 11 | 20354 | 210 | 34936356 |
Blood bilirubin increased | 35.91 | 14.66 | 73 | 20292 | 38223 | 34898343 |
Splenic embolism | 34.69 | 14.66 | 10 | 20355 | 189 | 34936377 |
Type III immune complex mediated reaction | 34.35 | 14.66 | 11 | 20354 | 300 | 34936266 |
Drug eruption | 33.26 | 14.66 | 49 | 20316 | 19849 | 34916717 |
Mycobacterium tuberculosis complex test positive | 33.20 | 14.66 | 16 | 20349 | 1316 | 34935250 |
Strongyloidiasis | 32.36 | 14.66 | 20 | 20345 | 2691 | 34933875 |
Optic atrophy | 32.31 | 14.66 | 14 | 20351 | 900 | 34935666 |
Tuberculin test positive | 32.09 | 14.66 | 15 | 20350 | 1152 | 34935414 |
Sideroblastic anaemia | 32.09 | 14.66 | 10 | 20355 | 249 | 34936317 |
Vitamin B1 decreased | 29.48 | 14.66 | 10 | 20355 | 328 | 34936238 |
Product dose omission issue | 28.81 | 14.66 | 17 | 20348 | 119694 | 34816872 |
Peritoneal tuberculosis | 28.62 | 14.66 | 10 | 20355 | 359 | 34936207 |
Pain | 28.61 | 14.66 | 47 | 20318 | 204628 | 34731938 |
Atrial fibrillation | 28.60 | 14.66 | 18 | 20347 | 122375 | 34814191 |
Colour blindness | 27.95 | 14.66 | 9 | 20356 | 250 | 34936316 |
Eosinophilia | 27.01 | 14.66 | 52 | 20313 | 26170 | 34910396 |
Mycobacterium fortuitum infection | 26.65 | 14.66 | 8 | 20357 | 175 | 34936391 |
Condition aggravated | 26.45 | 14.66 | 197 | 20168 | 191999 | 34744567 |
Pathogen resistance | 26.30 | 14.66 | 30 | 20335 | 9452 | 34927114 |
Lichenoid keratosis | 26.19 | 14.66 | 17 | 20348 | 2491 | 34934075 |
Marrow hyperplasia | 26.09 | 14.66 | 13 | 20352 | 1150 | 34935416 |
Encephalopathy | 25.91 | 14.66 | 61 | 20304 | 35258 | 34901308 |
Diarrhoea | 25.40 | 14.66 | 129 | 20236 | 389783 | 34546783 |
Liver injury | 25.39 | 14.66 | 37 | 20328 | 14841 | 34921725 |
Rash maculo-papular | 25.22 | 14.66 | 53 | 20312 | 28398 | 34908168 |
Hypotension | 24.83 | 14.66 | 58 | 20307 | 221591 | 34714975 |
Ocular toxicity | 24.58 | 14.66 | 8 | 20357 | 230 | 34936336 |
Splenic abscess | 24.52 | 14.66 | 9 | 20356 | 373 | 34936193 |
Pancytopenia | 24.44 | 14.66 | 115 | 20250 | 95042 | 34841524 |
Dyspnoea | 24.34 | 14.66 | 125 | 20240 | 376657 | 34559909 |
Myocardial infarction | 24.16 | 14.66 | 21 | 20344 | 121064 | 34815502 |
Encephalitis | 23.61 | 14.66 | 25 | 20340 | 7252 | 34929314 |
Completed suicide | 23.53 | 14.66 | 14 | 20351 | 98154 | 34838412 |
Oral candidiasis | 23.45 | 14.66 | 32 | 20333 | 12078 | 34924488 |
Malignant neoplasm progression | 23.40 | 14.66 | 11 | 20354 | 88035 | 34848531 |
Hepatic encephalopathy | 22.88 | 14.66 | 35 | 20330 | 14650 | 34921916 |
Urinary tract inflammation | 22.67 | 14.66 | 7 | 20358 | 169 | 34936397 |
Mitochondrial neurogastrointestinal encephalopathy | 22.55 | 14.66 | 4 | 20361 | 5 | 34936561 |
Feeling abnormal | 21.88 | 14.66 | 5 | 20360 | 63230 | 34873336 |
Hyperuricaemia | 21.56 | 14.66 | 25 | 20340 | 8018 | 34928548 |
Constipation | 21.51 | 14.66 | 29 | 20336 | 136953 | 34799613 |
Bovine tuberculosis | 21.36 | 14.66 | 6 | 20359 | 103 | 34936463 |
Genitourinary tract infection | 21.30 | 14.66 | 6 | 20359 | 104 | 34936462 |
Pulmonary sequestration | 21.28 | 14.66 | 5 | 20360 | 40 | 34936526 |
Autoimmune haemolytic anaemia | 21.28 | 14.66 | 19 | 20346 | 4477 | 34932089 |
Liver transplant | 21.26 | 14.66 | 15 | 20350 | 2519 | 34934047 |
Disseminated intravascular coagulation | 20.93 | 14.66 | 42 | 20323 | 21774 | 34914792 |
Papule | 20.60 | 14.66 | 18 | 20347 | 4121 | 34932445 |
Pulmonary granuloma | 20.09 | 14.66 | 12 | 20353 | 1518 | 34935048 |
Granulomatous lymphadenitis | 20 | 14.66 | 6 | 20359 | 131 | 34936435 |
Hepatic necrosis | 19.90 | 14.66 | 17 | 20348 | 3777 | 34932789 |
Urogenital infection bacterial | 19.77 | 14.66 | 5 | 20360 | 56 | 34936510 |
Chronic allograft nephropathy | 19.54 | 14.66 | 11 | 20354 | 1246 | 34935320 |
Dilatation intrahepatic duct acquired | 19.45 | 14.66 | 5 | 20360 | 60 | 34936506 |
Tuberculoid leprosy | 19.38 | 14.66 | 5 | 20360 | 61 | 34936505 |
Papilloma | 19.33 | 14.66 | 7 | 20358 | 279 | 34936287 |
Hereditary optic atrophy | 19.17 | 14.66 | 4 | 20361 | 17 | 34936549 |
Brain oedema | 18.86 | 14.66 | 31 | 20334 | 13790 | 34922776 |
Liver transplant rejection | 18.84 | 14.66 | 13 | 20352 | 2106 | 34934460 |
Conductive deafness | 18.78 | 14.66 | 7 | 20358 | 303 | 34936263 |
Febrile neutropenia | 18.57 | 14.66 | 32 | 20333 | 136817 | 34799749 |
Herpes zoster meningoencephalitis | 18.50 | 14.66 | 7 | 20358 | 316 | 34936250 |
Implant site infection | 18.20 | 14.66 | 10 | 20355 | 1080 | 34935486 |
Nasopharyngitis | 18.19 | 14.66 | 9 | 20356 | 69959 | 34866607 |
Past-pointing | 18.17 | 14.66 | 4 | 20361 | 23 | 34936543 |
Bilirubin conjugated increased | 17.86 | 14.66 | 15 | 20350 | 3256 | 34933310 |
Protrusion tongue | 17.80 | 14.66 | 6 | 20359 | 193 | 34936373 |
Vasculitis | 17.71 | 14.66 | 27 | 20338 | 11269 | 34925297 |
Lymphopenia | 17.57 | 14.66 | 33 | 20332 | 16302 | 34920264 |
Trisomy 21 | 17.56 | 14.66 | 8 | 20357 | 579 | 34935987 |
Renal atrophy | 17.42 | 14.66 | 10 | 20355 | 1175 | 34935391 |
Insomnia | 17.34 | 14.66 | 21 | 20344 | 103886 | 34832680 |
Psoas abscess | 17.24 | 14.66 | 8 | 20357 | 604 | 34935962 |
Cardiac failure congestive | 17.14 | 14.66 | 14 | 20351 | 83256 | 34853310 |
Spermatozoa progressive motility abnormal | 17.14 | 14.66 | 4 | 20361 | 31 | 34936535 |
Testicular mass | 17.13 | 14.66 | 5 | 20360 | 99 | 34936467 |
Generalised tonic-clonic seizure | 17.11 | 14.66 | 38 | 20327 | 21136 | 34915430 |
Neuropsychiatric symptoms | 17.09 | 14.66 | 9 | 20356 | 893 | 34935673 |
Cachexia | 17.06 | 14.66 | 21 | 20344 | 7165 | 34929401 |
Erythrodermic psoriasis | 17.05 | 14.66 | 9 | 20356 | 898 | 34935668 |
Unmasking of previously unidentified disease | 16.98 | 14.66 | 9 | 20356 | 905 | 34935661 |
Hemianopia heteronymous | 16.81 | 14.66 | 4 | 20361 | 34 | 34936532 |
Splenic infarction | 16.76 | 14.66 | 12 | 20353 | 2063 | 34934503 |
Dermatitis exfoliative | 16.74 | 14.66 | 20 | 20345 | 6619 | 34929947 |
Leprosy | 16.72 | 14.66 | 5 | 20360 | 108 | 34936458 |
Delayed graft function | 16.02 | 14.66 | 12 | 20353 | 2209 | 34934357 |
COVID-19 | 16.01 | 14.66 | 13 | 20352 | 77537 | 34859029 |
Cross sensitivity reaction | 15.90 | 14.66 | 10 | 20355 | 1387 | 34935179 |
Coma hepatic | 15.89 | 14.66 | 7 | 20358 | 468 | 34936098 |
Disease progression | 15.85 | 14.66 | 24 | 20341 | 108053 | 34828513 |
Spermatozoa progressive motility decreased | 15.80 | 14.66 | 5 | 20360 | 131 | 34936435 |
Optic disc hyperaemia | 15.74 | 14.66 | 3 | 20362 | 7 | 34936559 |
Peripheral swelling | 15.59 | 14.66 | 13 | 20352 | 76528 | 34860038 |
Myxoedema coma | 15.59 | 14.66 | 6 | 20359 | 284 | 34936282 |
Splenomegaly | 15.59 | 14.66 | 30 | 20335 | 15087 | 34921479 |
Thrombosis | 15.55 | 14.66 | 5 | 20360 | 50453 | 34886113 |
Hepatitis cholestatic | 15.39 | 14.66 | 21 | 20344 | 7926 | 34928640 |
Renal transplant failure | 15.38 | 14.66 | 9 | 20356 | 1097 | 34935469 |
Ototoxicity | 15.28 | 14.66 | 11 | 20354 | 1906 | 34934660 |
Transplant rejection | 15.26 | 14.66 | 24 | 20341 | 10287 | 34926279 |
Cryptococcosis | 15.11 | 14.66 | 12 | 20353 | 2407 | 34934159 |
Fatigue | 14.98 | 14.66 | 141 | 20224 | 370512 | 34566054 |
Trichoglossia | 14.87 | 14.66 | 6 | 20359 | 322 | 34936244 |
Hepatocellular injury | 14.83 | 14.66 | 37 | 20328 | 22174 | 34914392 |
Chronic obstructive pulmonary disease | 14.81 | 14.66 | 5 | 20360 | 48913 | 34887653 |
Adrenocortical insufficiency acute | 14.66 | 14.66 | 10 | 20355 | 1590 | 34934976 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Paradoxical drug reaction | 1263.69 | 12.59 | 348 | 37824 | 6837 | 79699379 |
Drug reaction with eosinophilia and systemic symptoms | 981.55 | 12.59 | 519 | 37653 | 63725 | 79642491 |
Drug-induced liver injury | 950.70 | 12.59 | 513 | 37659 | 65604 | 79640612 |
Immune reconstitution inflammatory syndrome | 625.28 | 12.59 | 239 | 37933 | 13602 | 79692614 |
Hepatotoxicity | 524.39 | 12.59 | 319 | 37853 | 51033 | 79655183 |
Jaundice | 510.63 | 12.59 | 318 | 37854 | 53031 | 79653185 |
Drug resistance | 493.03 | 12.59 | 286 | 37886 | 41927 | 79664289 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 436.11 | 12.59 | 97 | 38075 | 739 | 79705477 |
Acute hepatic failure | 411.02 | 12.59 | 226 | 37946 | 29887 | 79676329 |
Tuberculosis | 386.02 | 12.59 | 174 | 37998 | 15024 | 79691192 |
Tuberculoma of central nervous system | 366.84 | 12.59 | 79 | 38093 | 508 | 79705708 |
Hepatitis | 350.29 | 12.59 | 256 | 37916 | 55471 | 79650745 |
Pulmonary tuberculosis | 334.41 | 12.59 | 130 | 38042 | 7735 | 79698481 |
Drug interaction | 246.20 | 12.59 | 584 | 37588 | 414599 | 79291617 |
Pyrexia | 195.49 | 12.59 | 739 | 37433 | 677970 | 79028246 |
Hepatic encephalopathy | 170.10 | 12.59 | 119 | 38053 | 24047 | 79682169 |
Disseminated tuberculosis | 149.46 | 12.59 | 61 | 38111 | 4122 | 79702094 |
Hepatic function abnormal | 146.80 | 12.59 | 178 | 37994 | 72929 | 79633287 |
Meningitis tuberculous | 138.69 | 12.59 | 42 | 38130 | 1163 | 79705053 |
Loss of employment | 136.18 | 12.59 | 50 | 38122 | 2537 | 79703679 |
Hepatic failure | 134.38 | 12.59 | 156 | 38016 | 61056 | 79645160 |
Lymphadenopathy | 127.57 | 12.59 | 142 | 38030 | 53105 | 79653111 |
Alanine aminotransferase increased | 124.70 | 12.59 | 254 | 37918 | 162316 | 79543900 |
Lymph node tuberculosis | 119.53 | 12.59 | 36 | 38136 | 978 | 79705238 |
Immune system disorder | 116.26 | 12.59 | 70 | 38102 | 10959 | 79695257 |
Transaminases increased | 112.11 | 12.59 | 131 | 38041 | 51612 | 79654604 |
Drug level decreased | 108.59 | 12.59 | 74 | 38098 | 14328 | 79691888 |
Hepatitis toxic | 103.01 | 12.59 | 50 | 38122 | 5097 | 79701119 |
Aspartate aminotransferase increased | 102.03 | 12.59 | 213 | 37959 | 138428 | 79567788 |
Liver injury | 97.95 | 12.59 | 128 | 38044 | 56486 | 79649730 |
Hydrocephalus | 95.14 | 12.59 | 57 | 38115 | 8843 | 79697373 |
Pain | 92.61 | 12.59 | 121 | 38051 | 703681 | 79002535 |
Eosinophilia | 85.49 | 12.59 | 107 | 38065 | 45238 | 79660978 |
Tuberculosis gastrointestinal | 83.56 | 12.59 | 24 | 38148 | 550 | 79705666 |
Fall | 81.91 | 12.59 | 68 | 38104 | 487561 | 79218655 |
Encephalopathy | 80.79 | 12.59 | 128 | 38044 | 67269 | 79638947 |
Optic neuropathy | 79.36 | 12.59 | 37 | 38135 | 3447 | 79702769 |
Liver function test abnormal | 78.04 | 12.59 | 123 | 38049 | 64352 | 79641864 |
Tuberculosis of central nervous system | 78.01 | 12.59 | 22 | 38150 | 471 | 79705745 |
Optic neuritis | 74.35 | 12.59 | 50 | 38122 | 9470 | 79696746 |
Liver disorder | 72.68 | 12.59 | 127 | 38045 | 72290 | 79633926 |
Hepatitis fulminant | 71.18 | 12.59 | 44 | 38128 | 7218 | 79698998 |
Latent tuberculosis | 68.39 | 12.59 | 33 | 38139 | 3320 | 79702896 |
Generalised tonic-clonic seizure | 67.89 | 12.59 | 94 | 38078 | 43816 | 79662400 |
Granuloma | 65.81 | 12.59 | 44 | 38128 | 8253 | 79697963 |
Drug abuse | 65.18 | 12.59 | 3 | 38169 | 162688 | 79543528 |
Peritoneal tuberculosis | 63.73 | 12.59 | 19 | 38153 | 498 | 79705718 |
Pancreatitis haemorrhagic | 62.72 | 12.59 | 21 | 38151 | 809 | 79705407 |
Mycobacterial infection | 62.66 | 12.59 | 32 | 38140 | 3636 | 79702580 |
Fatigue | 60.56 | 12.59 | 235 | 37937 | 929492 | 78776724 |
Liver transplant | 59.76 | 12.59 | 33 | 38139 | 4390 | 79701826 |
Multiple-drug resistance | 58.78 | 12.59 | 42 | 38130 | 8766 | 79697450 |
Death | 57.85 | 12.59 | 115 | 38057 | 566399 | 79139817 |
Bone tuberculosis | 57.38 | 12.59 | 18 | 38154 | 562 | 79705654 |
Face oedema | 57.24 | 12.59 | 69 | 38103 | 28067 | 79678149 |
Complications of transplanted kidney | 55.96 | 12.59 | 36 | 38136 | 6330 | 79699886 |
Rash maculo-papular | 55.82 | 12.59 | 98 | 38074 | 55980 | 79650236 |
Tuberculous pleurisy | 55.44 | 12.59 | 18 | 38154 | 629 | 79705587 |
Product dose omission issue | 54.71 | 12.59 | 25 | 38147 | 247512 | 79458704 |
Hepatic necrosis | 53.07 | 12.59 | 40 | 38132 | 9060 | 79697156 |
Blood bilirubin increased | 52.51 | 12.59 | 105 | 38067 | 66127 | 79640089 |
Granulomatous liver disease | 49.54 | 12.59 | 20 | 38152 | 1313 | 79704903 |
Bovine tuberculosis | 48.15 | 12.59 | 12 | 38160 | 156 | 79706060 |
Strongyloidiasis | 47.02 | 12.59 | 27 | 38145 | 3871 | 79702345 |
Hepatocellular injury | 45.85 | 12.59 | 82 | 38090 | 47511 | 79658705 |
Hepatic steatosis | 45.66 | 12.59 | 72 | 38100 | 37666 | 79668550 |
Disseminated intravascular coagulation | 45.62 | 12.59 | 70 | 38102 | 35772 | 79670444 |
Tuberculin test positive | 44.88 | 12.59 | 25 | 38147 | 3383 | 79702833 |
Pathogen resistance | 44.62 | 12.59 | 44 | 38128 | 14298 | 79691918 |
Synovitis | 44.47 | 12.59 | 9 | 38163 | 150725 | 79555491 |
Arthropathy | 43.86 | 12.59 | 15 | 38157 | 177096 | 79529120 |
Hemianopia heteronymous | 43.67 | 12.59 | 10 | 38162 | 88 | 79706128 |
Sinusitis | 42.79 | 12.59 | 20 | 38152 | 195481 | 79510735 |
Wound | 41.12 | 12.59 | 4 | 38168 | 116175 | 79590041 |
Tubulointerstitial nephritis | 40.90 | 12.59 | 69 | 38103 | 38166 | 79668050 |
Liver transplant rejection | 40.53 | 12.59 | 23 | 38149 | 3225 | 79702991 |
Diaphragmatic injury | 40.41 | 12.59 | 10 | 38162 | 126 | 79706090 |
Thalamic infarction | 39.77 | 12.59 | 17 | 38155 | 1290 | 79704926 |
Demodicidosis | 39.53 | 12.59 | 11 | 38161 | 224 | 79705992 |
Distributive shock | 38.94 | 12.59 | 21 | 38151 | 2666 | 79703550 |
Skin disorder | 38.65 | 12.59 | 63 | 38109 | 33880 | 79672336 |
Central nervous system vasculitis | 38.55 | 12.59 | 17 | 38155 | 1391 | 79704825 |
Mycobacterium tuberculosis complex test positive | 38.19 | 12.59 | 21 | 38151 | 2771 | 79703445 |
Peripheral swelling | 37.81 | 12.59 | 44 | 38128 | 269573 | 79436643 |
Sideroblastic anaemia | 37.58 | 12.59 | 11 | 38161 | 270 | 79705946 |
Pleural effusion | 37.29 | 12.59 | 153 | 38019 | 145109 | 79561107 |
Coagulopathy | 37.23 | 12.59 | 64 | 38108 | 35942 | 79670274 |
Glomerulonephritis minimal lesion | 36.99 | 12.59 | 14 | 38158 | 773 | 79705443 |
Joint swelling | 36.44 | 12.59 | 51 | 38121 | 288595 | 79417621 |
Encephalitis | 36.43 | 12.59 | 40 | 38132 | 14720 | 79691496 |
Nasopharyngitis | 36.06 | 12.59 | 41 | 38131 | 253840 | 79452376 |
Discomfort | 36.03 | 12.59 | 8 | 38164 | 125609 | 79580607 |
Splenic embolism | 36.01 | 12.59 | 10 | 38162 | 202 | 79706014 |
Toxic epidermal necrolysis | 35.72 | 12.59 | 71 | 38101 | 44510 | 79661706 |
Lower respiratory tract infection | 35.54 | 12.59 | 9 | 38163 | 129211 | 79577005 |
Oral candidiasis | 35.11 | 12.59 | 56 | 38116 | 29572 | 79676644 |
Neuropathy peripheral | 34.83 | 12.59 | 147 | 38025 | 141158 | 79565058 |
Pyelonephritis fungal | 34.82 | 12.59 | 10 | 38162 | 229 | 79705987 |
Diarrhoea | 34.77 | 12.59 | 263 | 37909 | 880226 | 78825990 |
Malignant neoplasm progression | 34.58 | 12.59 | 11 | 38161 | 135979 | 79570237 |
Tuberculosis of eye | 34.02 | 12.59 | 8 | 38164 | 80 | 79706136 |
Bilirubin conjugated increased | 33.75 | 12.59 | 25 | 38147 | 5514 | 79700702 |
Feeling abnormal | 33.75 | 12.59 | 17 | 38155 | 159182 | 79547034 |
Transplant rejection | 33.68 | 12.59 | 44 | 38128 | 19393 | 79686823 |
Renal transplant failure | 33.63 | 12.59 | 17 | 38155 | 1890 | 79704326 |
Insomnia | 33.32 | 12.59 | 41 | 38131 | 245129 | 79461087 |
Infection | 33.29 | 12.59 | 40 | 38132 | 241672 | 79464544 |
Hand deformity | 33.28 | 12.59 | 5 | 38167 | 103914 | 79602302 |
Gastric disorder | 32.91 | 12.59 | 62 | 38110 | 37371 | 79668845 |
Drug eruption | 32.86 | 12.59 | 68 | 38104 | 43867 | 79662349 |
Ocular toxicity | 31.99 | 12.59 | 13 | 38159 | 868 | 79705348 |
Cholestatic liver injury | 31.69 | 12.59 | 23 | 38149 | 4918 | 79701298 |
Mycoplasma genitalium infection | 31.56 | 12.59 | 6 | 38166 | 18 | 79706198 |
Pemphigus | 31.42 | 12.59 | 5 | 38167 | 99577 | 79606639 |
Contusion | 31.37 | 12.59 | 16 | 38156 | 148760 | 79557456 |
Pneumocystis jirovecii pneumonia | 31.30 | 12.59 | 56 | 38116 | 32452 | 79673764 |
Oedematous kidney | 31.26 | 12.59 | 9 | 38163 | 208 | 79706008 |
Hepatic enzyme increased | 31.25 | 12.59 | 171 | 38001 | 182439 | 79523777 |
Alopecia | 31.11 | 12.59 | 39 | 38133 | 231316 | 79474900 |
Jarisch-Herxheimer reaction | 30.95 | 12.59 | 13 | 38159 | 944 | 79705272 |
Swelling | 30.77 | 12.59 | 35 | 38137 | 216676 | 79489540 |
Splenic abscess | 29.46 | 12.59 | 11 | 38161 | 585 | 79705631 |
Myocardial infarction | 29.25 | 12.59 | 27 | 38145 | 184102 | 79522114 |
Coma hepatic | 29.07 | 12.59 | 13 | 38159 | 1100 | 79705116 |
Cachexia | 29.04 | 12.59 | 31 | 38141 | 11052 | 79695164 |
Febrile neutropenia | 28.96 | 12.59 | 41 | 38131 | 230958 | 79475258 |
Hypertransaminasaemia | 28.88 | 12.59 | 32 | 38140 | 11892 | 79694324 |
Lichenoid keratosis | 28.59 | 12.59 | 20 | 38152 | 4037 | 79702179 |
Cerebrovascular accident | 28.12 | 12.59 | 20 | 38152 | 155272 | 79550944 |
Optic atrophy | 27.71 | 12.59 | 15 | 38157 | 1918 | 79704298 |
Hypotension | 27.45 | 12.59 | 113 | 38059 | 440204 | 79266012 |
Ocular icterus | 27.34 | 12.59 | 22 | 38150 | 5478 | 79700738 |
Muscle spasms | 27.30 | 12.59 | 26 | 38146 | 174704 | 79531512 |
Immunosuppressant drug level decreased | 27.21 | 12.59 | 15 | 38157 | 1989 | 79704227 |
Hepatomegaly | 27.08 | 12.59 | 39 | 38133 | 18835 | 79687381 |
Mycobacterium fortuitum infection | 26.75 | 12.59 | 8 | 38164 | 212 | 79706004 |
Constipation | 26.69 | 12.59 | 60 | 38112 | 282990 | 79423226 |
Congestive hepatopathy | 26.54 | 12.59 | 20 | 38152 | 4527 | 79701689 |
Pulmonary granuloma | 26.41 | 12.59 | 15 | 38157 | 2106 | 79704110 |
Vitamin B1 decreased | 26.41 | 12.59 | 10 | 38162 | 553 | 79705663 |
Focal dyscognitive seizures | 26.36 | 12.59 | 18 | 38154 | 3494 | 79702722 |
Pancreatitis acute | 26.27 | 12.59 | 67 | 38105 | 49537 | 79656679 |
Aplasia pure red cell | 26.25 | 12.59 | 25 | 38147 | 7785 | 79698431 |
Pericardial effusion | 26.11 | 12.59 | 64 | 38108 | 46173 | 79660043 |
Hyperuricaemia | 25.75 | 12.59 | 30 | 38142 | 11769 | 79694447 |
Myocarditis | 25.65 | 12.59 | 41 | 38131 | 21692 | 79684524 |
Toxic optic neuropathy | 25.51 | 12.59 | 12 | 38160 | 1141 | 79705075 |
Oedematous pancreatitis | 25.36 | 12.59 | 12 | 38160 | 1156 | 79705060 |
Colour blindness | 25.21 | 12.59 | 9 | 38163 | 421 | 79705795 |
Back pain | 25.15 | 12.59 | 69 | 38103 | 304111 | 79402105 |
Completed suicide | 24.92 | 12.59 | 50 | 38122 | 245717 | 79460499 |
Type III immune complex mediated reaction | 24.61 | 12.59 | 10 | 38162 | 668 | 79705548 |
Substance-induced psychotic disorder | 24.57 | 12.59 | 17 | 38155 | 3372 | 79702844 |
Granulomatous lymphadenitis | 24.49 | 12.59 | 8 | 38164 | 285 | 79705931 |
Haemolytic anaemia | 24.38 | 12.59 | 36 | 38136 | 17784 | 79688432 |
Marrow hyperplasia | 24.22 | 12.59 | 13 | 38159 | 1635 | 79704581 |
COVID-19 | 24.01 | 12.59 | 24 | 38148 | 157650 | 79548566 |
Anxiety | 23.99 | 12.59 | 52 | 38120 | 248460 | 79457756 |
Pulmonary sequestration | 23.80 | 12.59 | 5 | 38167 | 28 | 79706188 |
Psoas abscess | 23.78 | 12.59 | 11 | 38161 | 1006 | 79705210 |
Papule | 23.56 | 12.59 | 23 | 38149 | 7384 | 79698832 |
Dyspnoea | 23.52 | 12.59 | 280 | 37892 | 856745 | 78849471 |
Epistaxis | 23.49 | 12.59 | 12 | 38160 | 111503 | 79594713 |
Herpes zoster meningoencephalitis | 23.49 | 12.59 | 10 | 38162 | 751 | 79705465 |
Hepatosplenomegaly | 23.45 | 12.59 | 21 | 38151 | 6048 | 79700168 |
Lupus-like syndrome | 23.44 | 12.59 | 31 | 38141 | 13826 | 79692390 |
Nicotinic acid deficiency | 23.42 | 12.59 | 7 | 38165 | 185 | 79706031 |
Cytomegalovirus infection | 23 | 12.59 | 58 | 38114 | 42586 | 79663630 |
Stevens-Johnson syndrome | 22.96 | 12.59 | 55 | 38117 | 39111 | 79667105 |
HIV infection | 22.71 | 12.59 | 11 | 38161 | 1116 | 79705100 |
Dry mouth | 22.59 | 12.59 | 7 | 38165 | 88012 | 79618204 |
Urogenital infection bacterial | 22.52 | 12.59 | 6 | 38166 | 103 | 79706113 |
Hereditary optic atrophy | 22.48 | 12.59 | 5 | 38167 | 38 | 79706178 |
Pancytopenia | 22.44 | 12.59 | 146 | 38026 | 165599 | 79540617 |
Impaired healing | 22.44 | 12.59 | 7 | 38165 | 87648 | 79618568 |
Aspergillus infection | 22.41 | 12.59 | 36 | 38136 | 19125 | 79687091 |
Brain oedema | 22.40 | 12.59 | 42 | 38130 | 25221 | 79680995 |
Cerebellar ataxia | 22.36 | 12.59 | 13 | 38159 | 1908 | 79704308 |
Gastrooesophageal reflux disease | 22.29 | 12.59 | 11 | 38161 | 104235 | 79601981 |
Treatment noncompliance | 22.10 | 12.59 | 65 | 38107 | 52203 | 79654013 |
Depression | 22.07 | 12.59 | 44 | 38128 | 216746 | 79489470 |
Metabolic acidosis | 22.02 | 12.59 | 88 | 38084 | 82441 | 79623775 |
Lymphadenitis | 21.84 | 12.59 | 18 | 38154 | 4637 | 79701579 |
Chromaturia | 21.83 | 12.59 | 42 | 38130 | 25704 | 79680512 |
Balance disorder | 21.80 | 12.59 | 10 | 38162 | 98847 | 79607369 |
Conductive deafness | 21.74 | 12.59 | 7 | 38165 | 238 | 79705978 |
Splenomegaly | 21.60 | 12.59 | 37 | 38135 | 20717 | 79685499 |
Adrenocortical insufficiency acute | 21.44 | 12.59 | 15 | 38157 | 3028 | 79703188 |
Systemic lupus erythematosus | 21.41 | 12.59 | 16 | 38156 | 121133 | 79585083 |
Bradycardia | 21.38 | 12.59 | 20 | 38152 | 135537 | 79570679 |
Seizure | 21.25 | 12.59 | 159 | 38013 | 188675 | 79517541 |
Gamma-glutamyltransferase increased | 21.24 | 12.59 | 66 | 38106 | 54614 | 79651602 |
Thrombosis | 21.03 | 12.59 | 7 | 38165 | 84093 | 79622123 |
Dizziness | 20.83 | 12.59 | 157 | 38015 | 526284 | 79179932 |
Mitochondrial neurogastrointestinal encephalopathy | 20.80 | 12.59 | 4 | 38168 | 13 | 79706203 |
Memory impairment | 20.74 | 12.59 | 14 | 38158 | 111720 | 79594496 |
Lymph node abscess | 20.66 | 12.59 | 5 | 38167 | 57 | 79706159 |
Choroiditis | 20.59 | 12.59 | 11 | 38161 | 1370 | 79704846 |
Stomatitis | 20.50 | 12.59 | 24 | 38148 | 146733 | 79559483 |
Ototoxicity | 20.45 | 12.59 | 15 | 38157 | 3259 | 79702957 |
Blood alkaline phosphatase increased | 20.40 | 12.59 | 72 | 38100 | 63592 | 79642624 |
Mastitis bacterial | 20.21 | 12.59 | 5 | 38167 | 63 | 79706153 |
Injury | 20.18 | 12.59 | 6 | 38166 | 77490 | 79628726 |
Joint tuberculosis | 20.06 | 12.59 | 6 | 38166 | 159 | 79706057 |
Pulmonary embolism | 20.02 | 12.59 | 32 | 38140 | 171622 | 79534594 |
Weight increased | 20.01 | 12.59 | 67 | 38105 | 277319 | 79428897 |
Pulmonary tuberculoma | 19.94 | 12.59 | 3 | 38169 | 0 | 79706216 |
Ascites | 19.70 | 12.59 | 80 | 38092 | 75482 | 79630734 |
Lymphocyte stimulation test positive | 19.69 | 12.59 | 10 | 38162 | 1123 | 79705093 |
Acid fast bacilli infection | 19.68 | 12.59 | 6 | 38166 | 170 | 79706046 |
Pseudomembranous colitis | 19.60 | 12.59 | 18 | 38154 | 5356 | 79700860 |
Testicular mass | 19.59 | 12.59 | 5 | 38167 | 72 | 79706144 |
Cryptococcosis | 19.59 | 12.59 | 15 | 38157 | 3478 | 79702738 |
Hepatitis B core antibody positive | 19.48 | 12.59 | 8 | 38164 | 549 | 79705667 |
Cholestasis | 19.41 | 12.59 | 62 | 38110 | 52047 | 79654169 |
Thrombocytopenia | 19.30 | 12.59 | 203 | 37969 | 265056 | 79441160 |
Mycobacterium abscessus infection | 18.97 | 12.59 | 10 | 38162 | 1212 | 79705004 |
Lung infiltration | 18.97 | 12.59 | 37 | 38135 | 22875 | 79683341 |
Papilloma | 18.84 | 12.59 | 7 | 38165 | 367 | 79705849 |
Wrong technique in product usage process | 18.73 | 12.59 | 6 | 38166 | 73869 | 79632347 |
Hyperinsulinaemia | 18.72 | 12.59 | 6 | 38166 | 201 | 79706015 |
Infectious pleural effusion | 18.66 | 12.59 | 15 | 38157 | 3729 | 79702487 |
Wheezing | 18.65 | 12.59 | 17 | 38155 | 116647 | 79589569 |
Disseminated mycobacterium avium complex infection | 18.44 | 12.59 | 6 | 38166 | 211 | 79706005 |
Chronic allograft nephropathy | 18.39 | 12.59 | 11 | 38161 | 1700 | 79704516 |
Pain in extremity | 18.34 | 12.59 | 101 | 38071 | 364437 | 79341779 |
Extrapulmonary tuberculosis | 18.30 | 12.59 | 7 | 38165 | 398 | 79705818 |
Central nervous system lesion | 18.28 | 12.59 | 27 | 38145 | 13341 | 79692875 |
Intestinal tuberculosis | 18.20 | 12.59 | 6 | 38166 | 220 | 79705996 |
Mobility decreased | 18.14 | 12.59 | 19 | 38153 | 122156 | 79584060 |
Nasal congestion | 18.07 | 12.59 | 7 | 38165 | 76545 | 79629671 |
Subacute hepatic failure | 17.92 | 12.59 | 6 | 38166 | 231 | 79705985 |
Spermatozoa progressive motility abnormal | 17.92 | 12.59 | 4 | 38168 | 31 | 79706185 |
Pericarditis tuberculous | 17.78 | 12.59 | 5 | 38167 | 106 | 79706110 |
Tuberculoid leprosy | 17.73 | 12.59 | 5 | 38167 | 107 | 79706109 |
Multiple organ dysfunction syndrome | 17.56 | 12.59 | 108 | 38064 | 120138 | 79586078 |
Hilar lymphadenopathy | 17.55 | 12.59 | 11 | 38161 | 1848 | 79704368 |
Urinary tract inflammation | 17.38 | 12.59 | 6 | 38166 | 254 | 79705962 |
Delayed graft function | 17.38 | 12.59 | 14 | 38158 | 3493 | 79702723 |
Coronary artery disease | 17.17 | 12.59 | 5 | 38167 | 65469 | 79640747 |
Fluid retention | 17.12 | 12.59 | 6 | 38166 | 69803 | 79636413 |
Lymphopenia | 16.94 | 12.59 | 42 | 38130 | 30515 | 79675701 |
Arachnoiditis | 16.86 | 12.59 | 8 | 38164 | 775 | 79705441 |
Genitourinary tract infection | 16.84 | 12.59 | 6 | 38166 | 279 | 79705937 |
Rebound effect | 16.83 | 12.59 | 19 | 38153 | 7207 | 79699009 |
Chronic obstructive pulmonary disease | 16.82 | 12.59 | 10 | 38162 | 85409 | 79620807 |
Vaginal flatulence | 16.54 | 12.59 | 12 | 38160 | 2563 | 79703653 |
Unmasking of previously unidentified disease | 16.53 | 12.59 | 11 | 38161 | 2046 | 79704170 |
Central venous pressure increased | 16.49 | 12.59 | 5 | 38167 | 139 | 79706077 |
Injection site pain | 16.31 | 12.59 | 23 | 38149 | 129815 | 79576401 |
Oesophageal candidiasis | 16.18 | 12.59 | 21 | 38151 | 9197 | 79697019 |
Hepatitis cholestatic | 16.16 | 12.59 | 26 | 38146 | 13826 | 79692390 |
Hepatic haematoma | 16.14 | 12.59 | 8 | 38164 | 853 | 79705363 |
Syncope | 16.13 | 12.59 | 39 | 38133 | 179410 | 79526806 |
Henoch-Schonlein purpura | 16.00 | 12.59 | 12 | 38160 | 2698 | 79703518 |
Blood pressure increased | 15.97 | 12.59 | 50 | 38122 | 211310 | 79494906 |
Hospitalisation | 15.95 | 12.59 | 13 | 38159 | 94223 | 79611993 |
Transient ischaemic attack | 15.84 | 12.59 | 3 | 38169 | 52692 | 79653524 |
Skin lesion | 15.78 | 12.59 | 50 | 38122 | 41794 | 79664422 |
Rash morbilliform | 15.76 | 12.59 | 17 | 38155 | 6133 | 79700083 |
Leprosy | 15.73 | 12.59 | 5 | 38167 | 163 | 79706053 |
Infusion related reaction | 15.67 | 12.59 | 57 | 38115 | 230180 | 79476036 |
Erythrodermic psoriasis | 15.59 | 12.59 | 10 | 38162 | 1748 | 79704468 |
Ill-defined disorder | 15.59 | 12.59 | 6 | 38166 | 65869 | 79640347 |
Sedation | 15.51 | 12.59 | 3 | 38169 | 51892 | 79654324 |
Spermatozoa progressive motility decreased | 15.46 | 12.59 | 4 | 38168 | 61 | 79706155 |
Rheumatoid arthritis | 15.27 | 12.59 | 50 | 38122 | 208420 | 79497796 |
Renal atrophy | 15.25 | 12.59 | 10 | 38162 | 1815 | 79704401 |
Hepatitis acute | 15.25 | 12.59 | 27 | 38145 | 15515 | 79690701 |
Hypermetabolism | 15.19 | 12.59 | 6 | 38166 | 372 | 79705844 |
Bone pain | 15.10 | 12.59 | 4 | 38168 | 55738 | 79650478 |
Implant site infection | 15.05 | 12.59 | 10 | 38162 | 1855 | 79704361 |
Intentional product misuse | 15.05 | 12.59 | 14 | 38158 | 95151 | 79611065 |
Hyperbilirubinaemia | 14.99 | 12.59 | 35 | 38137 | 24483 | 79681733 |
Neuropsychiatric symptoms | 14.96 | 12.59 | 9 | 38163 | 1406 | 79704810 |
Spleen palpable | 14.92 | 12.59 | 3 | 38169 | 13 | 79706203 |
Injection site reaction | 14.71 | 12.59 | 4 | 38168 | 54781 | 79651435 |
Vaginal discharge | 14.68 | 12.59 | 18 | 38154 | 7445 | 79698771 |
Shock | 14.60 | 12.59 | 50 | 38122 | 43498 | 79662718 |
Autoimmune haemolytic anaemia | 14.57 | 12.59 | 19 | 38153 | 8361 | 79697855 |
Amnesia | 14.50 | 12.59 | 6 | 38166 | 63051 | 79643165 |
Optic disc hyperaemia | 14.41 | 12.59 | 3 | 38169 | 16 | 79706200 |
Visual pathway disorder | 14.35 | 12.59 | 4 | 38168 | 82 | 79706134 |
Disseminated Bacillus Calmette-Guerin infection | 14.34 | 12.59 | 5 | 38167 | 218 | 79705998 |
Chest pain | 14.31 | 12.59 | 78 | 38094 | 282226 | 79423990 |
Pneumonia cryptococcal | 14.28 | 12.59 | 9 | 38163 | 1526 | 79704690 |
Haemophagocytic lymphohistiocytosis | 14.26 | 12.59 | 32 | 38140 | 21805 | 79684411 |
CD4 lymphocytes | 14.25 | 12.59 | 3 | 38169 | 17 | 79706199 |
Cutaneous tuberculosis | 14.13 | 12.59 | 5 | 38167 | 228 | 79705988 |
Hypersensitivity vasculitis | 14.07 | 12.59 | 17 | 38155 | 6926 | 79699290 |
Dysphagia | 14.02 | 12.59 | 23 | 38149 | 122113 | 79584103 |
Cardiac disorder | 13.96 | 12.59 | 7 | 38165 | 65750 | 79640466 |
Chylothorax | 13.93 | 12.59 | 7 | 38165 | 768 | 79705448 |
Drug level fluctuating | 13.90 | 12.59 | 7 | 38165 | 772 | 79705444 |
Vomiting | 13.66 | 12.59 | 416 | 37756 | 665412 | 79040804 |
Pancreatitis | 13.65 | 12.59 | 67 | 38105 | 68508 | 79637708 |
Acinetobacter infection | 13.58 | 12.59 | 11 | 38161 | 2766 | 79703450 |
Oligohydramnios | 13.57 | 12.59 | 12 | 38160 | 3400 | 79702816 |
Musculoskeletal stiffness | 13.50 | 12.59 | 41 | 38131 | 174967 | 79531249 |
Orthostatic hypotension | 13.48 | 12.59 | 5 | 38167 | 56159 | 79650057 |
Dehydration | 13.46 | 12.59 | 67 | 38105 | 248120 | 79458096 |
Atrial fibrillation | 13.45 | 12.59 | 49 | 38123 | 197837 | 79508379 |
Food interaction | 13.44 | 12.59 | 9 | 38163 | 1693 | 79704523 |
Nocardiosis | 13.34 | 12.59 | 15 | 38157 | 5664 | 79700552 |
Interstitial lung disease | 13.34 | 12.59 | 96 | 38076 | 112504 | 79593712 |
Urinary tract infection | 13.29 | 12.59 | 77 | 38095 | 274435 | 79431781 |
Illness | 13.26 | 12.59 | 3 | 38169 | 46508 | 79659708 |
Nephrotic syndrome | 13.07 | 12.59 | 21 | 38151 | 11153 | 79695063 |
Methylobacterium infection | 13.04 | 12.59 | 3 | 38169 | 27 | 79706189 |
Hypersensitivity | 12.99 | 12.59 | 73 | 38099 | 262166 | 79444050 |
Intentional product use issue | 12.94 | 12.59 | 34 | 38138 | 152078 | 79554138 |
Pleurisy | 12.69 | 12.59 | 20 | 38152 | 10455 | 79695761 |
None
Source | Code | Description |
---|---|---|
ATC | J04AC01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Hydrazides |
ATC | J04AC51 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Hydrazides |
ATC | J04AM01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
ATC | J04AM02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
ATC | J04AM03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
ATC | J04AM04 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
ATC | J04AM05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
ATC | J04AM06 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
ATC | J04AM07 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
ATC | J04AM08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
FDA EPC | N0000175483 | Antimycobacterial |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000995 | Antitubercular Agents |
MeSH PA | D054872 | Fatty Acid Synthesis Inhibitors |
MeSH PA | D000960 | Hypolipidemic Agents |
CHEBI has role | CHEBI:33231 | antitubercular agents |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Inactive tuberculosis | indication | 11999007 | |
Acute tuberculosis | indication | 25629007 | |
Pulmonary tuberculosis | indication | 154283005 | DOID:2957 |
Tuberculosis of meninges | off-label use | 58437007 | |
Atypical mycobacterial infection | off-label use | 111812000 | |
Nutritional disorder | contraindication | 2492009 | DOID:374 |
Alcoholism | contraindication | 7200002 | |
Jaundice | contraindication | 18165001 | |
Acute hepatitis | contraindication | 37871000 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Gout | contraindication | 90560007 | DOID:13189 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Acute hepatic failure | contraindication | 197270009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Diabetic - poor control | contraindication | 268519009 | |
Peripheral nerve disease | contraindication | 302226006 | |
Porphyria | contraindication | 418470004 | |
Diabetic peripheral neuropathy | contraindication | 424736006 | |
Slow acetylator due to N-acetyltransferase enzyme variant | contraindication | 425079005 | |
Prolonged-Severe Nausea and Vomiting | contraindication | ||
Chronic Hepatic Disease | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.98 | acidic |
pKa2 | 3.79 | Basic |
pKa3 | 1.94 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 3A5 | Enzyme | IC50 | 4.96 | WOMBAT-PK | |||||
Cytochrome P450 3A4 | Enzyme | IC50 | 5.31 | WOMBAT-PK | |||||
Myeloperoxidase | Enzyme | IC50 | 5.33 | CHEMBL | |||||
Enoyl-[acyl-carrier-protein] reductase [NADH] | Enzyme | INHIBITOR | IC50 | 5.08 | CHEMBL | CHEMBL | |||
Catalase-peroxidase | Enzyme | WOMBAT-PK | |||||||
Dihydrofolate reductase | Enzyme | Ki | 9 | CHEMBL |
ID | Source |
---|---|
4017505 | VUID |
N0000145890 | NUI |
D00346 | KEGG_DRUG |
4017505 | VANDF |
C0022209 | UMLSCUI |
CHEBI:6030 | CHEBI |
ISZ | PDB_CHEM_ID |
CHEMBL64 | ChEMBL_ID |
DB00951 | DRUGBANK_ID |
D007538 | MESH_DESCRIPTOR_UI |
3767 | PUBCHEM_CID |
4188 | INN_ID |
12761 | IUPHAR_LIGAND_ID |
V83O1VOZ8L | UNII |
6038 | RXNORM |
2955 | MMSL |
4929 | MMSL |
d00101 | MMSL |
002844 | NDDF |
387472004 | SNOMEDCT_US |
81335000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-1655 | TABLET | 300 mg | ORAL | ANDA | 24 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-7655 | TABLET | 300 mg | ORAL | ANDA | 22 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1109 | TABLET | 300 mg | ORAL | ANDA | 24 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0066 | TABLET | 100 mg | ORAL | ANDA | 24 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0555-0071 | TABLET | 300 mg | ORAL | ANDA | 24 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3056 | INJECTION, SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 25 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3056 | INJECTION, SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 25 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-584 | TABLET | 300 mg | ORAL | ANDA | 22 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-087 | TABLET | 300 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-121 | TABLET | 300 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-218 | TABLET | 300 mg | ORAL | ANDA | 22 sections |
ISONIAZID | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-984 | TABLET | 300 mg | ORAL | ANDA | 13 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-627 | TABLET | 300 mg | ORAL | ANDA | 22 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-463 | TABLET | 300 mg | ORAL | ANDA | 24 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-463 | TABLET | 300 mg | ORAL | ANDA | 24 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 46287-009 | SOLUTION | 50 mg | ORAL | ANDA | 24 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0370 | TABLET | 300 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0370 | TABLET | 300 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0370 | TABLET | 300 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0410 | TABLET | 100 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0410 | TABLET | 100 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1490 | SOLUTION | 50 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51079-083 | TABLET | 300 mg | ORAL | ANDA | 24 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51655-391 | TABLET | 300 mg | ORAL | ANDA | 10 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-145 | TABLET | 300 mg | ORAL | ANDA | 22 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-2920 | TABLET | 300 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-2920 | TABLET | 300 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53808-1041 | TABLET | 300 mg | ORAL | ANDA | 23 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-2304 | TABLET | 100 mg | ORAL | ANDA | 24 sections |
Isoniazid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-2416 | TABLET | 300 mg | ORAL | ANDA | 24 sections |