sulfamethoxazole Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-infectives, sulfonamides 2514 723-46-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • sulfamethoxazole
  • sulfamethalazole
  • sulfamethoxazol
  • sulfisomezole
  • sulphamethoxazole
A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)
  • Molecular weight: 253.28
  • Formula: C10H11N3O3S
  • CLOGP: 0.56
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 98.22
  • ALOGS: -2.74
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.39 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 14 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 394.82 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.36 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.23 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.80 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 30, 1973 FDA MONARCH PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 892.41 9.62 1992 122813 241833 46319424
Drug reaction with eosinophilia and systemic symptoms 463.97 9.62 479 124326 29069 46532188
Pyrexia 429.78 9.62 1956 122849 346846 46214411
Febrile neutropenia 410.49 9.62 830 123975 93797 46467460
Neutropenia 367.99 9.62 1024 123781 142180 46419077
Pancytopenia 340.56 9.62 722 124083 84336 46476921
Thrombocytopenia 339.92 9.62 920 123885 125661 46435596
Completed suicide 273.63 9.62 34 124771 145886 46415371
Cytomegalovirus infection 271.97 9.62 287 124518 17857 46543400
Drug ineffective 244.48 9.62 961 123844 676877 45884380
Pneumocystis jirovecii pneumonia 231.76 9.62 243 124562 15005 46546252
Rheumatoid arthritis 205.00 9.62 204 124601 240011 46321246
Rash maculo-papular 199.57 9.62 305 124500 27569 46533688
Agranulocytosis 191.18 9.62 265 124540 21920 46539337
Stevens-Johnson syndrome 187.02 9.62 269 124536 23028 46538229
Toxic epidermal necrolysis 182.90 9.62 260 124545 22018 46539239
Neutrophil count decreased 176.39 9.62 371 124434 43055 46518202
Bronchopulmonary aspergillosis 170.04 9.62 149 124656 7347 46553910
Nocardiosis 163.66 9.62 82 124723 1535 46559722
Fall 159.16 9.62 408 124397 328689 46232568
Hepatocellular injury 147.37 9.62 275 124530 29247 46532010
Febrile bone marrow aplasia 142.96 9.62 130 124675 6732 46554525
Leukopenia 141.34 9.62 453 124352 67890 46493367
Platelet count decreased 134.56 9.62 577 124228 99447 46461810
Hyperkalaemia 134.29 9.62 367 124438 50342 46510915
Acute kidney injury 134.20 9.62 1083 123722 234772 46326485
Toxicity to various agents 130.31 9.62 229 124576 211537 46349720
Rash 128.69 9.62 1487 123318 355025 46206232
Drug abuse 120.69 9.62 14 124791 63394 46497863
White blood cell count decreased 116.23 9.62 600 124205 111631 46449626
Injection site pain 113.83 9.62 73 124732 107079 46454178
Folliculitis 112.86 9.62 109 124696 6094 46555163
Pain in extremity 111.35 9.62 339 124466 258341 46302916
Muscle injury 110.92 9.62 97 124708 4769 46556488
Pain 108.29 9.62 789 124016 476159 46085098
Lymphopenia 107.56 9.62 166 124639 15127 46546130
Septic shock 107.44 9.62 370 124435 57523 46503734
Cytokine release syndrome 101.45 9.62 103 124702 6120 46555137
Alopecia 101.35 9.62 174 124631 162240 46399017
Immunosuppressant drug level increased 101.22 9.62 78 124727 3204 46558053
Bone marrow failure 99.66 9.62 235 124570 29434 46531823
Plasma cell myeloma 99.47 9.62 303 124502 44175 46517082
Anaemia 98.53 9.62 1081 123724 254698 46306559
Toxic skin eruption 97.90 9.62 142 124663 12245 46549012
Sepsis 93.87 9.62 654 124151 135360 46425897
Encephalitis viral 91.36 9.62 56 124749 1574 46559683
Intentional overdose 91.03 9.62 30 124775 64914 46496343
Interstitial lung disease 90.86 9.62 334 124471 53615 46507642
Lymphocyte count decreased 90.68 9.62 207 124598 25382 46535875
Tumour lysis syndrome 90.30 9.62 104 124701 7132 46554125
Blood pressure increased 88.23 9.62 126 124679 126540 46434717
Psoriasis 85.61 9.62 52 124753 78552 46482705
Transplant rejection 84.72 9.62 116 124689 9480 46551777
Congenital umbilical hernia 82.14 9.62 35 124770 443 46560814
Eosinophilia 80.12 9.62 166 124639 19051 46542206
Hepatic function abnormal 79.32 9.62 237 124568 34184 46527073
Pre-engraftment immune reaction 78.83 9.62 28 124777 208 46561049
Deafness transitory 78.77 9.62 51 124754 1581 46559676
Death 77.49 9.62 552 124253 334996 46226261
Injection site erythema 77.27 9.62 52 124753 74375 46486882
Headache 75.53 9.62 867 123938 477485 46083772
BK virus infection 73.54 9.62 61 124744 2788 46558469
Polyomavirus-associated nephropathy 72.99 9.62 47 124758 1443 46559814
Feeling abnormal 72.61 9.62 140 124665 124920 46436337
Overdose 71.45 9.62 101 124704 101878 46459379
Hypogammaglobulinaemia 70.98 9.62 80 124725 5358 46555899
Myocardial infarction 70.94 9.62 94 124711 97434 46463823
Cholestasis 70.53 9.62 194 124611 26699 46534558
Wrong technique in product usage process 69.77 9.62 29 124776 54393 46506864
Thrombotic microangiopathy 69.73 9.62 98 124707 8208 46553049
Cytomegalovirus viraemia 69.17 9.62 72 124733 4406 46556851
Sleep disorder due to general medical condition, insomnia type 68.14 9.62 77 124728 5172 46556085
Blood creatinine increased 67.95 9.62 392 124413 76011 46485246
Product dose omission issue 66.75 9.62 229 124576 168291 46392966
Dizziness 66.08 9.62 587 124218 339827 46221430
Kidney transplant rejection 65.02 9.62 67 124738 4051 46557206
Arthralgia 63.83 9.62 645 124160 363958 46197299
Human ehrlichiosis 62.54 9.62 23 124782 191 46561066
Posterior reversible encephalopathy syndrome 62.20 9.62 130 124675 15011 46546246
Suicide attempt 61.92 9.62 35 124770 55001 46506256
Suicidal ideation 61.81 9.62 37 124768 56345 46504912
Graft versus host disease 61.76 9.62 82 124723 6506 46554751
Epstein-Barr virus infection 61.39 9.62 83 124722 6701 46554556
Therapeutic product effect incomplete 60.30 9.62 72 124733 78081 46483176
Cardiac failure congestive 59.31 9.62 96 124709 91654 46469603
Product use in unapproved indication 59.28 9.62 429 124376 89844 46471413
Fatigue 59.16 9.62 1211 123594 607486 45953771
Depression 59.01 9.62 244 124561 169860 46391397
Injection site reaction 58.96 9.62 27 124778 47822 46513435
Pneumomediastinum 58.54 9.62 38 124767 1183 46560074
Renal tubular acidosis 56.35 9.62 41 124764 1542 46559715
Intentional product misuse 55.91 9.62 28 124777 47100 46514157
Haemophagocytic lymphohistiocytosis 55.12 9.62 88 124717 8254 46553003
Malaise 55.07 9.62 593 124212 330639 46230618
Immune reconstitution inflammatory syndrome 54.81 9.62 72 124733 5653 46555604
Human herpesvirus 6 infection 54.35 9.62 48 124757 2391 46558866
Enterococcal infection 53.62 9.62 79 124726 6908 46554349
Palpitations 53.25 9.62 109 124696 95150 46466107
Aspergillus infection 53.01 9.62 78 124727 6812 46554445
Acute febrile neutrophilic dermatosis 52.31 9.62 49 124756 2636 46558621
Inappropriate schedule of product administration 52.20 9.62 58 124747 64955 46496302
Multiple organ dysfunction syndrome 51.77 9.62 274 124531 51436 46509821
Cytopenia 51.40 9.62 82 124723 7686 46553571
Complications of transplanted kidney 51.36 9.62 45 124760 2218 46559039
Injection site pruritus 51.23 9.62 21 124784 39722 46521535
Klebsiella infection 50.66 9.62 75 124730 6587 46554670
Infection 50.57 9.62 563 124242 133029 46428228
Gait disturbance 49.98 9.62 209 124596 145054 46416203
Birth mark 49.35 9.62 20 124785 221 46561036
Pseudomonas infection 48.80 9.62 91 124714 9667 46551590
Maternal exposure during pregnancy 47.98 9.62 129 124676 102420 46458837
Anxiety 47.11 9.62 289 124516 181668 46379589
Strongyloidiasis 46.66 9.62 29 124776 836 46560421
Mobility decreased 46.55 9.62 56 124749 60538 46500719
Injection site bruising 45.66 9.62 19 124786 35617 46525640
Accidental exposure to product 44.57 9.62 3 124802 21078 46540179
Injection site swelling 43.45 9.62 27 124778 40300 46520957
Irritable bowel syndrome 43.17 9.62 119 124686 16396 46544861
Pneumonia aspiration 42.96 9.62 183 124622 31422 46529835
Drug eruption 42.80 9.62 140 124665 21189 46540068
Brain abscess 42.78 9.62 36 124769 1679 46559578
Pulmonary alveolar haemorrhage 42.44 9.62 54 124751 4108 46557149
Hypophosphataemia 42.35 9.62 73 124732 7294 46553963
Infective pulmonary exacerbation of cystic fibrosis 42.32 9.62 91 124714 10716 46550541
Device expulsion 41.73 9.62 11 124794 27531 46533726
Rhinovirus infection 41.62 9.62 50 124755 3586 46557671
Hyperuricaemia 41.61 9.62 57 124748 4660 46556597
Hepatitis acute 41.58 9.62 77 124728 8137 46553120
Pemphigus 41.41 9.62 36 124769 45238 46516019
Pneumonia 41.21 9.62 1306 123499 375014 46186243
Product quality issue 41.07 9.62 22 124783 35626 46525631
Tenosynovitis stenosans 40.75 9.62 37 124768 1912 46559345
Aplasia 40.65 9.62 49 124756 3527 46557730
Intentional self-injury 39.91 9.62 8 124797 24158 46537099
Stomatitis 39.45 9.62 315 124490 67982 46493275
Pneumonia bacterial 39.33 9.62 68 124737 6811 46554446
Bacterial sepsis 39.12 9.62 48 124757 3519 46557738
Hypofibrinogenaemia 38.74 9.62 28 124777 1042 46560215
Synovial fluid analysis 38.70 9.62 31 124774 1348 46559909
Balance disorder 38.50 9.62 71 124734 64450 46496807
Haemolytic anaemia 37.54 9.62 82 124723 9760 46551497
Aplastic anaemia 37.40 9.62 68 124737 7085 46554172
Drug-induced liver injury 36.92 9.62 150 124655 25218 46536039
Cerebrovascular accident 36.87 9.62 142 124663 100897 46460360
Toxoplasmosis 36.30 9.62 30 124775 1364 46559893
Myelosuppression 36.25 9.62 70 124735 7633 46553624
Mucosal erosion 36.23 9.62 30 124775 1368 46559889
Drug withdrawal syndrome 36.06 9.62 14 124791 27370 46533887
Chronic obstructive pulmonary disease 35.67 9.62 62 124743 57571 46503686
Osteoarthritis 35.48 9.62 70 124735 61955 46499302
Systemic candida 35.39 9.62 40 124765 2687 46558570
Renal impairment 35.09 9.62 328 124477 74044 46487213
Incorrect dose administered 35.09 9.62 42 124763 45508 46515749
Functional gastrointestinal disorder 35.06 9.62 43 124762 3151 46558106
Hypertriglyceridaemia 34.74 9.62 58 124747 5646 46555611
Upper respiratory tract inflammation 34.59 9.62 40 124765 2755 46558502
Trimethylaminuria 34.52 9.62 14 124791 155 46561102
Conjunctivitis 34.40 9.62 105 124700 15319 46545938
Drug intolerance 34.28 9.62 241 124564 146808 46414449
Ureaplasma infection 34.21 9.62 19 124786 442 46560815
Memory impairment 34.16 9.62 100 124705 77237 46484020
Glossodynia 34.09 9.62 41 124764 44332 46516925
Blister 33.97 9.62 220 124585 44411 46516846
Hyponatraemia 33.86 9.62 417 124388 100915 46460342
Pseudohyponatraemia 33.85 9.62 11 124794 60 46561197
Respiratory failure 33.79 9.62 395 124410 94421 46466836
Pneumonia fungal 33.32 9.62 48 124757 4112 46557145
Cushingoid 33.31 9.62 60 124745 6206 46555051
Pneumonia cytomegaloviral 32.97 9.62 33 124772 1927 46559330
Gastrointestinal disorder 32.90 9.62 272 124533 59304 46501953
Blood lactate dehydrogenase increased 32.90 9.62 125 124680 20375 46540882
Renal transplant failure 32.81 9.62 21 124784 638 46560619
Enterocolitis 32.71 9.62 59 124746 6109 46555148
Hypoalbuminaemia 32.69 9.62 79 124726 10048 46551209
Graft versus host disease in gastrointestinal tract 32.41 9.62 37 124768 2513 46558744
Pneumonia influenzal 32.24 9.62 29 124776 1480 46559777
Breast cancer 31.94 9.62 45 124760 45473 46515784
Osteonecrosis of jaw 31.89 9.62 27 124778 34375 46526882
Bicytopenia 31.71 9.62 30 124775 1634 46559623
Acute graft versus host disease 31.55 9.62 46 124759 3984 46557273
Dysbiosis 31.35 9.62 19 124786 523 46560734
Pneumonia streptococcal 31.24 9.62 30 124775 1665 46559592
Acute generalised exanthematous pustulosis 31.04 9.62 74 124731 9331 46551926
Cytomegalovirus test positive 31.01 9.62 38 124767 2782 46558475
Cerebral toxoplasmosis 30.95 9.62 21 124784 705 46560552
Acute respiratory distress syndrome 30.62 9.62 128 124677 21794 46539463
Pseudoporphyria 30.55 9.62 13 124792 164 46561093
Stress 30.52 9.62 57 124748 51494 46509763
Alanine aminotransferase increased 30.42 9.62 366 124439 88085 46473172
Purpura 30.36 9.62 76 124729 9882 46551375
Obliterative bronchiolitis 30.07 9.62 30 124775 1745 46559512
Drug dependence 30.05 9.62 8 124797 19893 46541364
Systemic lupus erythematosus 29.72 9.62 83 124722 65097 46496160
Knee arthroplasty 29.70 9.62 13 124792 23652 46537605
Delayed graft function 29.65 9.62 23 124782 954 46560303
Cholestatic liver injury 29.44 9.62 32 124773 2058 46559199
Mixed liver injury 29.27 9.62 39 124766 3104 46558153
Pharyngitis 28.86 9.62 108 124697 17475 46543782
Angina pectoris 28.74 9.62 18 124787 26757 46534500
Hyperhidrosis 28.57 9.62 132 124673 89176 46472081
Cerebral microhaemorrhage 28.57 9.62 11 124794 105 46561152
West Nile viral infection 28.55 9.62 16 124789 379 46560878
Scleritis 28.46 9.62 37 124768 2875 46558382
C-reactive protein increased 28.44 9.62 260 124545 58330 46502927
Injection site haemorrhage 28.26 9.62 10 124795 20699 46540558
Necrosis ischaemic 28.08 9.62 21 124784 824 46560433
Mucosal inflammation 27.77 9.62 189 124616 38787 46522470
Shock symptom 27.71 9.62 9 124796 49 46561208
Coagulation test abnormal 27.48 9.62 19 124786 658 46560599
Arthritis 27.35 9.62 110 124695 77206 46484051
Clostridium difficile colitis 27.23 9.62 110 124695 18443 46542814
Coronary artery disease 27.21 9.62 30 124775 33722 46527535
Eyelid scar 27.18 9.62 7 124798 13 46561244
Cytomegalovirus infection reactivation 27.03 9.62 26 124779 1446 46559811
Poisoning 26.85 9.62 3 124802 13991 46547266
Hypophagia 26.45 9.62 151 124654 29155 46532102
Depressed mood 26.44 9.62 30 124775 33289 46527968
Loss of consciousness 26.40 9.62 175 124630 108063 46453194
Serotonin syndrome 26.39 9.62 16 124789 24204 46537053
Exposure during pregnancy 26.38 9.62 175 124630 108037 46453220
Herpes simplex oesophagitis 26.34 9.62 11 124794 132 46561125
Injection site warmth 26.30 9.62 3 124802 13769 46547488
Bradycardia 26.28 9.62 90 124715 66208 46495049
Graft loss 26.15 9.62 15 124790 372 46560885
Cardio-respiratory arrest 26.01 9.62 78 124727 59791 46501466
Chest pain 25.99 9.62 324 124481 176000 46385257
Pseudomembranous colitis 25.79 9.62 37 124768 3158 46558099
Gamma-glutamyltransferase increased 25.73 9.62 159 124646 31581 46529676
Aplasia pure red cell 25.63 9.62 44 124761 4381 46556876
Fixed eruption 25.46 9.62 20 124785 845 46560412
Lung transplant rejection 25.31 9.62 19 124786 750 46560507
Bronchiectasis 25.22 9.62 68 124737 9248 46552009
Lymph node palpable 25.05 9.62 10 124795 106 46561151
Pathogen resistance 24.85 9.62 52 124753 6008 46555249
Drug resistance 24.72 9.62 102 124703 17266 46543991
Infection reactivation 24.70 9.62 19 124786 778 46560479
Lupus enteritis 24.65 9.62 9 124796 73 46561184
Chest discomfort 24.59 9.62 141 124664 90128 46471129
Migraine 24.53 9.62 100 124705 69926 46491331
Bacterial infection 24.49 9.62 97 124708 16119 46545138
Respiratory arrest 24.16 9.62 33 124772 33783 46527474
Mucocutaneous rash 24.14 9.62 7 124798 24 46561233
Mycobacterium abscessus infection 24.09 9.62 17 124788 609 46560648
Bacteraemia 24.03 9.62 88 124717 14091 46547166
Herpes simplex 24.02 9.62 57 124748 7166 46554091
Brain stem glioma 23.94 9.62 9 124796 80 46561177
Dyspnoea 23.88 9.62 1131 123674 514417 46046840
Lower respiratory tract infection 23.55 9.62 238 124567 54851 46506406
Hypoaldosteronism 23.28 9.62 11 124794 180 46561077
Meningitis aseptic 23.04 9.62 40 124765 4019 46557238
Uveal prolapse 23.00 9.62 6 124799 12 46561245
Autoimmune haemolytic anaemia 22.93 9.62 41 124764 4217 46557040
Pleuritic pain 22.83 9.62 52 124753 6364 46554893
Blood glucose increased 22.70 9.62 107 124698 71906 46489351
Psoriatic arthropathy 22.63 9.62 39 124766 36340 46524917
Acute myopia 22.57 9.62 9 124796 95 46561162
Hypertension 22.56 9.62 379 124426 195977 46365280
Pseudomyopia 22.23 9.62 8 124797 62 46561195
Squamous cell carcinoma of skin 22.09 9.62 45 124760 5102 46556155
Desmoplastic small round cell tumour 21.95 9.62 10 124795 150 46561107
Scedosporium infection 21.92 9.62 15 124790 511 46560746
Lymphocele 21.75 9.62 18 124787 820 46560437
Beta haemolytic streptococcal infection 21.66 9.62 26 124779 1863 46559394
Coma 21.64 9.62 245 124560 58104 46503153
Rash morbilliform 21.63 9.62 33 124772 2976 46558281
Hand deformity 21.57 9.62 37 124768 34537 46526720
Cystitis haemorrhagic 21.51 9.62 36 124769 3511 46557746
Antithrombin III decreased 21.46 9.62 12 124793 283 46560974
Progressive multifocal leukoencephalopathy 21.45 9.62 73 124732 11273 46549984
Hyperbilirubinaemia 21.38 9.62 69 124736 10369 46550888
Eye infection toxoplasmal 21.34 9.62 12 124793 286 46560971
Asthma 21.33 9.62 150 124655 91392 46469865
Disseminated intravascular coagulation 21.32 9.62 104 124701 18901 46542356
Paraesthesia 21.19 9.62 206 124599 117231 46444026
Hip arthroplasty 21.12 9.62 11 124794 18101 46543156
Porphyria acute 21.09 9.62 13 124792 369 46560888
Sleep disorder 21.03 9.62 60 124745 46735 46514522
Aspartate aminotransferase increased 20.98 9.62 311 124494 78389 46482868
Injection site mass 20.97 9.62 7 124798 15033 46546224
Product substitution issue 20.95 9.62 7 124798 15024 46546233
Adverse event 20.94 9.62 37 124768 34147 46527110
Condition aggravated 20.93 9.62 497 124308 244555 46316702
Reticulocytopenia 20.90 9.62 8 124797 75 46561182
Oesophageal candidiasis 20.60 9.62 44 124761 5156 46556101
Feeding disorder 20.53 9.62 67 124738 10127 46551130
Sopor 20.37 9.62 14 124791 19814 46541443
Flushing 20.37 9.62 96 124709 64518 46496739
Cytomegalovirus hepatitis 20.34 9.62 12 124793 314 46560943
HIV infection 20.30 9.62 15 124790 578 46560679
Renal failure 20.26 9.62 421 124384 113173 46448084
Hyperthermia 20.21 9.62 57 124748 7957 46553300
Crepitations 20.17 9.62 48 124757 6044 46555213
Femur fracture 20.10 9.62 43 124762 36954 46524303
Liver disorder 20.00 9.62 169 124636 37077 46524180
Dermo-hypodermitis 19.88 9.62 11 124794 254 46561003
Pancreatitis acute 19.78 9.62 124 124681 24748 46536509
Cytokine storm 19.72 9.62 11 124794 258 46560999
Meningoencephalitis herpetic 19.72 9.62 19 124786 1059 46560198
Pulmonary mucormycosis 19.69 9.62 8 124797 89 46561168
Injection site urticaria 19.68 9.62 4 124801 11963 46549294
Vitiligo 19.67 9.62 19 124786 1062 46560195
Acute lymphocytic leukaemia recurrent 19.52 9.62 26 124779 2069 46559188
Chylothorax 19.35 9.62 11 124794 268 46560989
Renal tubular necrosis 19.28 9.62 68 124737 10691 46550566
No adverse event 19.26 9.62 39 124766 34192 46527065
Acute myocardial infarction 19.16 9.62 35 124770 31889 46529368
Acquired immunodeficiency syndrome 19.08 9.62 8 124797 97 46561160
Gait inability 19.05 9.62 41 124764 35162 46526095
Pneumocystis jirovecii infection 19.04 9.62 20 124785 1237 46560020
Amnesia 18.99 9.62 53 124752 41578 46519679
Pulmonary nocardiosis 18.86 9.62 8 124797 100 46561157
Disseminated cryptococcosis 18.85 9.62 11 124794 282 46560975
Photophobia 18.83 9.62 83 124722 14461 46546796
Hyperammonaemia 18.80 9.62 40 124765 4676 46556581
Nephropathy toxic 18.78 9.62 53 124752 7401 46553856
Neck pain 18.73 9.62 80 124725 55226 46506031
Foot deformity 18.54 9.62 9 124796 15416 46545841
Petechiae 18.50 9.62 75 124730 12595 46548662
Lung disorder 18.46 9.62 187 124618 43117 46518140
Hypoaesthesia 18.43 9.62 216 124589 118653 46442604
Renal transplant 18.41 9.62 20 124785 1285 46559972
Product use issue 18.38 9.62 163 124642 94481 46466776
Primary myelofibrosis 18.35 9.62 7 124798 65 46561192
Escherichia pyelonephritis 18.31 9.62 12 124793 380 46560877
Laryngeal stenosis 18.28 9.62 15 124790 675 46560582
Conjunctivalisation 18.27 9.62 5 124800 13 46561244
Cardiovascular disorder 18.21 9.62 5 124800 12182 46549075
Hypertensive cardiomyopathy 18.18 9.62 10 124795 228 46561029
Asteatosis 18.16 9.62 7 124798 67 46561190
Enteritis infectious 18.15 9.62 25 124780 2054 46559203
Post transplant lymphoproliferative disorder 18.10 9.62 35 124770 3821 46557436
Unevaluable event 18.08 9.62 63 124742 46112 46515145
Deafness 18.08 9.62 88 124717 15980 46545277
Candida sepsis 17.99 9.62 20 124785 1319 46559938
Focal myositis 17.98 9.62 6 124799 36 46561221
Drug level increased 17.96 9.62 97 124708 18344 46542913
Rheumatoid nodule 17.91 9.62 59 124746 8961 46552296
Venoocclusive disease 17.80 9.62 24 124781 1932 46559325
Treatment failure 17.77 9.62 161 124644 92926 46468331
Cholesteatoma 17.74 9.62 8 124797 117 46561140
Blood pressure fluctuation 17.72 9.62 34 124771 30414 46530843
Oropharyngeal candidiasis 17.62 9.62 17 124788 949 46560308
Chorioretinitis 17.61 9.62 11 124794 320 46560937
Pruritus 17.56 9.62 804 124001 241548 46319709
Liver transplant rejection 17.46 9.62 20 124785 1363 46559894
Myalgia 17.45 9.62 228 124577 122860 46438397
Escherichia urinary tract infection 17.44 9.62 64 124741 10259 46550998
Device malfunction 17.34 9.62 7 124798 13367 46547890
Varicella zoster virus infection 17.27 9.62 26 124779 2317 46558940
Umbilical erythema 17.22 9.62 7 124798 78 46561179
Parvovirus B19 infection 17.19 9.62 11 124794 334 46560923
Withdrawal syndrome 17.09 9.62 14 124791 18120 46543137
Chronic lymphocytic leukaemia 17.01 9.62 29 124776 2871 46558386
Acinetobacter infection 17.01 9.62 20 124785 1402 46559855
Respiratory syncytial virus infection 17.00 9.62 39 124766 4796 46556461
Abdominal discomfort 16.96 9.62 293 124512 150872 46410385
Rash erythematous 16.95 9.62 153 124652 34197 46527060
Oral candidiasis 16.93 9.62 92 124713 17440 46543817
Device dislocation 16.90 9.62 20 124785 21782 46539475
Diffuse large B-cell lymphoma 16.74 9.62 44 124761 5894 46555363
Rheumatoid factor positive 16.70 9.62 18 124787 20443 46540814
Nightmare 16.68 9.62 12 124793 16586 46544671
Escherichia infection 16.57 9.62 65 124740 10752 46550505
Diffuse alveolar damage 16.50 9.62 15 124790 776 46560481
Terminal ileitis 16.50 9.62 8 124797 139 46561118
Urinary tract infection 16.45 9.62 733 124072 219533 46341724
Mucormycosis 16.28 9.62 25 124780 2267 46558990
Hypertensive crisis 16.28 9.62 8 124797 13607 46547650
Immunosuppressant drug level decreased 16.25 9.62 16 124789 916 46560341
Granulomatosis with polyangiitis 16.23 9.62 22 124783 1780 46559477
Adenovirus infection 16.21 9.62 28 124777 2802 46558455
Tumour flare 16.13 9.62 10 124795 287 46560970
Hepatitis fulminant 16.11 9.62 31 124774 3371 46557886
JC virus infection 16.06 9.62 21 124784 1641 46559616
Gastrointestinal pain 15.92 9.62 50 124755 7405 46553852
Fungal infection 15.88 9.62 134 124671 29386 46531871
Pneumococcal infection 15.86 9.62 11 124794 383 46560874
Swollen tongue 15.86 9.62 34 124771 29198 46532059
Crying 15.75 9.62 20 124785 21121 46540136
Exostosis 15.74 9.62 4 124801 10259 46550998
Hepatitis 15.65 9.62 143 124662 32072 46529185
Immunoglobulins decreased 15.64 9.62 15 124790 831 46560426
Diabetic eye disease 15.58 9.62 8 124797 158 46561099
Respiratory tract infection viral 15.50 9.62 22 124783 1859 46559398
Unresponsive to stimuli 15.40 9.62 40 124765 32134 46529123
Hot flush 15.33 9.62 62 124743 43455 46517802
Microsporidia infection 15.31 9.62 9 124796 234 46561023
Cardiac arrest 15.30 9.62 161 124644 90238 46471019
Cell-mediated immune deficiency 15.28 9.62 5 124800 28 46561229
Cytomegalovirus syndrome 15.24 9.62 7 124798 107 46561150
Haemolysis 15.18 9.62 43 124762 6016 46555241
Coronavirus infection 15.17 9.62 27 124778 2767 46558490
Steroid diabetes 15.15 9.62 13 124792 623 46560634
Cardiac disorder 15.13 9.62 63 124742 43795 46517462
Disseminated varicella zoster vaccine virus infection 15.08 9.62 6 124799 63 46561194
Muscle spasms 15.00 9.62 235 124570 122878 46438379
Parainfluenzae virus infection 14.90 9.62 21 124784 1763 46559494
Peripheral motor neuropathy 14.81 9.62 19 124786 1457 46559800
Device issue 14.78 9.62 19 124786 19961 46541296
Skin erosion 14.76 9.62 24 124781 2285 46558972
Polyneuropathy 14.74 9.62 66 124739 11578 46549679
Hyperglycaemia 14.73 9.62 151 124654 34920 46526337
Flank pain 14.68 9.62 67 124738 11846 46549411
Metastases to bone 14.68 9.62 15 124790 17461 46543796
Lung neoplasm malignant 14.55 9.62 12 124793 15477 46545780
Weight increased 14.46 9.62 332 124473 164141 46397116
Systemic mycosis 14.46 9.62 15 124790 914 46560343
Heart rate increased 14.43 9.62 129 124676 74662 46486595
Systemic inflammatory response syndrome 14.33 9.62 39 124766 5332 46555925
Graft versus host disease in skin 14.32 9.62 24 124781 2343 46558914
Discomfort 14.32 9.62 70 124735 46600 46514657
Septal panniculitis 14.15 9.62 6 124799 75 46561182
Infusion related reaction 14.15 9.62 188 124617 101020 46460237
Bandaemia 13.98 9.62 5 124800 38 46561219
Grip strength decreased 13.90 9.62 3 124802 8603 46552654
Excessive eye blinking 13.84 9.62 12 124793 583 46560674
Dyskinesia 13.81 9.62 36 124769 28889 46532368
Dermatitis exfoliative 13.78 9.62 40 124765 5676 46555581
Clubbing 13.76 9.62 9 124796 284 46560973
Swelling 13.75 9.62 242 124563 124269 46436988
Pelvic venous thrombosis 13.64 9.62 19 124786 1578 46559679
Multiple sclerosis relapse 13.62 9.62 62 124743 42063 46519194
Medication error 13.62 9.62 40 124765 30871 46530386
Cataract 13.43 9.62 69 124736 45346 46515911
Hepatic necrosis 13.31 9.62 39 124766 5562 46555695
Pain in jaw 13.31 9.62 55 124750 38317 46522940
Chemical burn of oral cavity 13.29 9.62 6 124799 88 46561169
Blood alkaline phosphatase increased 13.22 9.62 163 124642 39446 46521811
Product complaint 13.18 9.62 8 124797 12093 46549164
Culture stool positive 13.14 9.62 9 124796 307 46560950
Candida infection 13.06 9.62 103 124702 22137 46539120
Throat irritation 13.03 9.62 37 124768 28864 46532393
Chronic lymphocytic leukaemia refractory 12.96 9.62 5 124800 48 46561209
Haemolytic transfusion reaction 12.94 9.62 4 124801 18 46561239
Therapy cessation 12.82 9.62 33 124772 26596 46534661
Acute lymphocytic leukaemia 12.81 9.62 25 124780 2748 46558509
Synovial cyst 12.80 9.62 46 124759 7300 46553957
Device related bacteraemia 12.76 9.62 4 124801 19 46561238
Transient ischaemic attack 12.76 9.62 49 124756 34854 46526403
Opportunistic infection 12.72 9.62 19 124786 1682 46559575
Anger 12.68 9.62 8 124797 11844 46549413
Leukoencephalopathy 12.67 9.62 31 124774 3973 46557284
Herpes simplex viraemia 12.64 9.62 7 124798 162 46561095
Lipase increased 12.62 9.62 51 124754 8552 46552705
Dermatitis bullous 12.59 9.62 47 124758 7596 46553661
Product storage error 12.56 9.62 8 124797 11784 46549473
Gastroenteritis 12.53 9.62 109 124696 24110 46537147
Multiple sclerosis 12.50 9.62 30 124775 24761 46536496
Mood swings 12.50 9.62 15 124790 16237 46545020
Ill-defined disorder 12.49 9.62 118 124687 26709 46534548
Road traffic accident 12.48 9.62 28 124777 23663 46537594
Clostridium difficile infection 12.48 9.62 112 124693 24991 46536266
Myoclonus 12.33 9.62 73 124732 14279 46546978
Inappropriate antidiuretic hormone secretion 12.29 9.62 72 124733 14030 46547227
Erythema multiforme 12.28 9.62 55 124750 9649 46551608
Pneumonia pseudomonal 12.28 9.62 21 124784 2085 46559172
Serum sickness 12.25 9.62 23 124782 2455 46558802
Joint swelling 12.25 9.62 344 124461 165729 46395528
Cerebral aspergillosis 12.22 9.62 9 124796 345 46560912
Respiratory depression 12.17 9.62 8 124797 11592 46549665
C-reactive protein abnormal 12.16 9.62 24 124781 21246 46540011
Feeling hot 12.16 9.62 56 124749 37872 46523385
Vomiting 12.14 9.62 1385 123420 451409 46109848
Sedation 12.14 9.62 27 124778 22883 46538374
Hypertransaminasaemia 12.11 9.62 28 124777 3460 46557797
Syncope 12.11 9.62 202 124603 104601 46456656
Anorexia nervosa 12.08 9.62 7 124798 177 46561080
Rash papular 11.99 9.62 67 124738 12831 46548426
Amegakaryocytic thrombocytopenia 11.99 9.62 4 124801 24 46561233
Natural killer cell count 11.99 9.62 4 124801 24 46561233
Stenotrophomonas infection 11.98 9.62 18 124787 1602 46559655
Face oedema 11.97 9.62 90 124715 19063 46542194
Human herpesvirus 6 encephalitis 11.89 9.62 6 124799 114 46561143
Hyperamylasaemia 11.86 9.62 9 124796 361 46560896
Lacrimation increased 11.82 9.62 15 124790 15846 46545411
Hepatitis cholestatic 11.79 9.62 42 124763 6635 46554622
Palmar-plantar erythrodysaesthesia syndrome 11.76 9.62 23 124782 20428 46540829
Heart transplant rejection 11.74 9.62 10 124795 474 46560783
Hepatic infarction 11.72 9.62 11 124794 593 46560664
Psychotic disorder 11.71 9.62 27 124778 22594 46538663
Influenza like illness 11.68 9.62 98 124707 57472 46503785
Haematochezia 11.64 9.62 56 124749 37437 46523820
Intracranial pressure increased 11.62 9.62 31 124774 4189 46557068
Tooth abscess 11.60 9.62 10 124795 12623 46548634
Macrophages increased 11.59 9.62 4 124801 27 46561230
Viral haemorrhagic cystitis 11.58 9.62 11 124794 602 46560655
Escherichia sepsis 11.54 9.62 31 124774 4207 46557050
Pseudomonas test positive 11.53 9.62 12 124793 734 46560523
Limb injury 11.52 9.62 21 124784 19153 46542104
Urticaria 11.52 9.62 404 124401 117488 46443769
Antinuclear antibody positive 11.52 9.62 40 124765 6240 46555017
Anaphylactic shock 11.49 9.62 23 124782 20251 46541006
Drug interaction 11.47 9.62 658 124147 202436 46358821
Abortion spontaneous 11.44 9.62 69 124736 43577 46517680
Spinal stenosis 11.43 9.62 10 124795 12533 46548724
Therapeutic response decreased 11.42 9.62 68 124737 43077 46518180
Liver transplant 11.42 9.62 22 124783 2395 46558862
Henoch-Schonlein purpura 11.39 9.62 14 124791 1028 46560229
Central nervous system necrosis 11.35 9.62 6 124799 126 46561131
Fear 11.33 9.62 16 124789 16156 46545101
Tubulointerstitial nephritis 11.31 9.62 73 124732 14715 46546542
Investigation abnormal 11.31 9.62 14 124791 1036 46560221
Photodermatosis 11.30 9.62 9 124796 388 46560869
Osteoporosis 11.28 9.62 63 124742 40545 46520712
Campylobacter gastroenteritis 11.28 9.62 9 124796 389 46560868
Lichenification 11.26 9.62 9 124796 390 46560867
Hip fracture 11.24 9.62 35 124770 26521 46534736
Enterobacter infection 11.24 9.62 19 124786 1868 46559389
Deep vein thrombosis 11.22 9.62 286 124519 79487 46481770
Blood HIV RNULL 11.19 9.62 3 124802 7 46561250
Hypoglycaemic seizure 11.16 9.62 10 124795 508 46560749
Product prescribing error 11.14 9.62 23 124782 20024 46541233
Device breakage 11.13 9.62 6 124799 9686 46551571
Tooth disorder 11.13 9.62 29 124776 23274 46537983
Superinfection bacterial 11.12 9.62 9 124796 397 46560860
Limbal swelling 11.12 9.62 4 124801 31 46561226
Post procedural bile leak 11.10 9.62 6 124799 132 46561125
Asthenia 11.08 9.62 700 124105 310375 46250882
Toothache 11.06 9.62 17 124788 16575 46544682
Obesity 11.04 9.62 13 124792 14193 46547064
Acute myeloid leukaemia recurrent 11.02 9.62 16 124789 1380 46559877
Cachexia 11.01 9.62 33 124772 4766 46556491
Apnoea 10.99 9.62 3 124802 7336 46553921
Blood lactate dehydrogenase decreased 10.97 9.62 5 124800 75 46561182
Tarsal tunnel syndrome 10.97 9.62 11 124794 644 46560613
Transaminases increased 10.94 9.62 118 124687 27643 46533614
Diabetic macroangiopathy 10.94 9.62 6 124799 136 46561121
Coronary artery occlusion 10.90 9.62 4 124801 8098 46553159
Crystalluria 10.86 9.62 9 124796 411 46560846
Injection site induration 10.85 9.62 4 124801 8075 46553182
Shoulder arthroplasty 10.85 9.62 25 124780 3083 46558174
Cough 10.83 9.62 504 124301 229745 46331512
Dyspepsia 10.77 9.62 124 124681 68348 46492909
Dermatitis allergic 10.76 9.62 64 124741 12539 46548718
Alanine aminotransferase abnormal 10.73 9.62 22 124783 2505 46558752
Disability 10.69 9.62 7 124798 10160 46551097
Cheilitis 10.68 9.62 29 124776 3959 46557298
Rash macular 10.66 9.62 88 124717 19172 46542085
CD4 lymphocytes decreased 10.66 9.62 17 124788 1593 46559664
Neonatal pneumonia 10.65 9.62 3 124802 9 46561248
Ear infection 10.60 9.62 101 124704 22912 46538345
Rhabdomyolysis 10.60 9.62 67 124738 41842 46519415
Band sensation 10.59 9.62 11 124794 671 46560586
AIDS related complication 10.59 9.62 4 124801 36 46561221
Arthropathy 10.54 9.62 161 124644 84539 46476718
Death neonatal 10.53 9.62 7 124798 227 46561030
Device related infection 10.53 9.62 94 124711 20947 46540310
Escherichia bacteraemia 10.52 9.62 23 124782 2738 46558519
Cytomegalovirus enterocolitis 10.52 9.62 10 124795 548 46560709
Hyperferritinaemia 10.46 9.62 5 124800 84 46561173
Genital erosion 10.42 9.62 6 124799 150 46561107
Prothrombin level abnormal 10.41 9.62 5 124800 85 46561172
SJS-TEN overlap 10.38 9.62 6 124799 151 46561106
Leukaemia recurrent 10.33 9.62 15 124790 1294 46559963
Intracranial tumour haemorrhage 10.31 9.62 6 124799 153 46561104
Fluid retention 10.31 9.62 87 124718 50959 46510298
Renal lymphocele 10.31 9.62 5 124800 87 46561170
Dermatomyositis 10.30 9.62 19 124786 2002 46559255
Mitral valve disease 10.29 9.62 20 124785 2192 46559065
Respiratory disorder 10.28 9.62 115 124690 27185 46534072
Blood loss anaemia 10.27 9.62 5 124800 8552 46552705
Hepatosplenomegaly 10.26 9.62 21 124784 2389 46558868
Extrapyramidal disorder 10.25 9.62 9 124796 11259 46549998
Gynaecological chlamydia infection 10.22 9.62 4 124801 40 46561217
Cryptococcosis 10.22 9.62 12 124793 840 46560417
Epstein-Barr virus test positive 10.19 9.62 10 124795 570 46560687
Staphylococcal infection 10.18 9.62 143 124662 35628 46525629
Mitral valve incompetence 10.17 9.62 22 124783 18830 46542427
Speech disorder 10.11 9.62 56 124749 36111 46525146
Delusion 10.10 9.62 9 124796 11179 46550078
Mucocutaneous ulceration 10.07 9.62 6 124799 160 46561097
Enterococcal sepsis 10.06 9.62 15 124790 1325 46559932
Thrombotic thrombocytopenic purpura 10.04 9.62 28 124777 3882 46557375
Megacolon 10.04 9.62 17 124788 1674 46559583
Injection site discolouration 10.02 9.62 3 124802 6907 46554350
Gastrointestinal haemorrhage 10.00 9.62 146 124659 77227 46484030
Chronic hepatitis B 9.99 9.62 7 124798 248 46561009
Lymphadenitis viral 9.99 9.62 3 124802 12 46561245
Myeloid maturation arrest 9.99 9.62 3 124802 12 46561245
Vaginal haemorrhage 9.98 9.62 35 124770 25569 46535688
Disseminated mycobacterium avium complex infection 9.97 9.62 4 124801 43 46561214
Renal tubular disorder 9.93 9.62 21 124784 2444 46558813
Central nervous system fungal infection 9.91 9.62 5 124800 95 46561162
Immune thrombocytopenia 9.90 9.62 46 124759 8195 46553062
Nephrolithiasis 9.89 9.62 50 124755 33001 46528256
Fungal endocarditis 9.89 9.62 7 124798 252 46561005
Emotional disorder 9.88 9.62 11 124794 12313 46548944
Starvation 9.84 9.62 6 124799 167 46561090
Osteopenia 9.82 9.62 19 124786 16942 46544315
Panic attack 9.81 9.62 25 124780 20217 46541040
Blastomycosis 9.79 9.62 7 124798 256 46561001
Musculoskeletal discomfort 9.76 9.62 14 124791 14042 46547215
Labelled drug-drug interaction medication error 9.75 9.62 49 124756 9012 46552245
Pityriasis lichenoides et varioliformis acuta 9.73 9.62 4 124801 46 46561211
Cerebral fungal infection 9.73 9.62 4 124801 46 46561211
Abdominal wall infection 9.73 9.62 5 124800 99 46561158
Irritability 9.72 9.62 42 124763 28904 46532353
Epstein-Barr virus infection reactivation 9.72 9.62 7 124798 259 46560998
Enterovirus infection 9.71 9.62 10 124795 604 46560653
Serositis 9.71 9.62 10 124795 604 46560653
Illness 9.70 9.62 11 124794 12213 46549044
Prinzmetal angina 9.67 9.62 11 124794 744 46560513

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pyrexia 539.97 10.09 2601 126626 291888 29531363
Drug reaction with eosinophilia and systemic symptoms 438.98 10.09 577 128650 27911 29795340
Febrile neutropenia 426.79 10.09 1215 128012 105478 29717773
Completed suicide 325.44 10.09 28 129199 99464 29723787
Pancytopenia 322.90 10.09 951 128276 84101 29739150
Cytomegalovirus infection 322.89 10.09 452 128775 23222 29800029
Pneumocystis jirovecii pneumonia 311.74 10.09 377 128850 16743 29806508
Drug abuse 295.31 10.09 14 129213 82058 29741193
Hyperkalaemia 292.63 10.09 781 128446 65229 29758022
Neutropenia 287.91 10.09 1207 128020 127333 29695918
Death 235.16 10.09 776 128451 356507 29466744
Immune reconstitution inflammatory syndrome 230.28 10.09 238 128989 8863 29814388
Thrombocytopenia 221.78 10.09 1171 128056 135873 29687378
Toxicity to various agents 215.44 10.09 269 128958 176914 29646337
Rash maculo-papular 210.97 10.09 387 128840 25031 29798220
Acute kidney injury 208.85 10.09 1946 127281 271896 29551355
Cytomegalovirus viraemia 206.18 10.09 182 129045 5547 29817704
Agranulocytosis 202.57 10.09 350 128877 21592 29801659
Nocardiosis 193.04 10.09 142 129085 3313 29819938
Stevens-Johnson syndrome 164.61 10.09 282 128945 17274 29805977
Transplant rejection 163.12 10.09 200 129027 9006 29814245
Cytokine release syndrome 152.59 10.09 201 129026 9732 29813519
Neutrophil count decreased 150.76 10.09 464 128763 41990 29781261
Myocardial infarction 150.18 10.09 193 129034 125432 29697819
Leukopenia 147.67 10.09 555 128672 55604 29767647
Dizziness 135.68 10.09 412 128815 194497 29628754
Intentional overdose 131.98 10.09 13 129214 41468 29781783
Hepatocellular injury 128.89 10.09 317 128910 25154 29798097
Drug ineffective 119.49 10.09 920 128307 339467 29483784
Aspergillus infection 116.04 10.09 179 129048 10035 29813216
Platelet count decreased 115.03 10.09 818 128409 105311 29717940
Lymphocyte count decreased 113.72 10.09 253 128974 18802 29804449
Febrile bone marrow aplasia 110.94 10.09 155 129072 7942 29815309
Fall 109.74 10.09 409 128818 181463 29641788
Bronchopulmonary aspergillosis 109.51 10.09 193 129034 12091 29811160
Cholestasis 108.17 10.09 293 128934 24657 29798594
Suicide attempt 99.12 10.09 19 129208 36678 29786573
Cerebrovascular accident 96.87 10.09 131 129096 83346 29739905
Rash 96.12 10.09 1256 127971 190633 29632618
Lymphopenia 95.11 10.09 189 129038 12974 29810277
Anxiety 92.68 10.09 153 129074 89718 29733533
Thrombotic microangiopathy 92.40 10.09 147 129080 8463 29814788
Pain 89.31 10.09 412 128815 172229 29651022
Rheumatoid arthritis 89.26 10.09 33 129194 41164 29782087
Kidney transplant rejection 87.27 10.09 133 129094 7376 29815875
Fatigue 85.73 10.09 928 128299 319745 29503506
Septic shock 84.47 10.09 516 128711 63091 29760160
Product use in unapproved indication 83.29 10.09 574 128653 73119 29750132
Cardiac failure congestive 83.09 10.09 148 129079 84259 29738992
Depression 81.66 10.09 167 129060 90270 29732981
White blood cell count decreased 79.55 10.09 627 128600 83320 29739931
Toxic skin eruption 79.39 10.09 158 129069 10857 29812394
Product dose omission issue 77.91 10.09 175 129052 91456 29731795
Haemophagocytic lymphohistiocytosis 77.35 10.09 146 129081 9645 29813606
Aplasia 76.90 10.09 91 129136 3946 29819305
Sepsis 75.64 10.09 964 128263 145431 29677820
Acute febrile neutrophilic dermatosis 75.31 10.09 52 129175 1094 29822157
Overdose 75.07 10.09 157 129070 84180 29739071
Bone marrow failure 73.83 10.09 289 128938 29496 29793755
Graft versus host disease 73.64 10.09 146 129081 10004 29813247
Arthralgia 73.22 10.09 319 128908 135472 29687779
Blood creatinine increased 73.06 10.09 657 128570 90718 29732533
Dermatitis exfoliative generalised 70.09 10.09 73 129154 2742 29820509
Coronary artery disease 69.61 10.09 67 129160 49645 29773606
Pseudomonas infection 69.20 10.09 145 129082 10337 29812914
Acute myocardial infarction 68.86 10.09 76 129151 52863 29770388
Loss of consciousness 68.77 10.09 150 129077 79225 29744026
Chronic lymphocytic leukaemia 68.54 10.09 92 129135 4536 29818715
Epstein-Barr virus infection 67.21 10.09 111 129116 6595 29816656
Aggression 66.84 10.09 38 129189 36869 29786382
Congenital umbilical hernia 66.50 10.09 33 129194 362 29822889
Toxic epidermal necrolysis 65.43 10.09 198 129029 17742 29805509
Hepatitis 64.67 10.09 228 128999 22128 29801123
Injection site pain 64.45 10.09 25 129202 30285 29792966
Pain in extremity 62.44 10.09 254 128973 109967 29713284
Blood pressure increased 62.25 10.09 136 129091 71792 29751459
Blood lactate dehydrogenase increased 62.10 10.09 213 129014 20388 29802863
Therapeutic product effect decreased 61.79 10.09 24 129203 29052 29794199
Somnolence 61.30 10.09 213 129014 96550 29726701
Pneumonia 61.04 10.09 1879 127348 332427 29490824
Rash morbilliform 60.72 10.09 64 129163 2438 29820813
Feeling abnormal 60.01 10.09 95 129132 56661 29766590
Pathogen resistance 59.85 10.09 120 129107 8290 29814961
Syncope 58.55 10.09 180 129047 84723 29738528
Pneumonia cytomegaloviral 58.24 10.09 66 129161 2730 29820521
Anaemia 58.20 10.09 1238 127989 206754 29616497
Chest pain 57.09 10.09 287 128940 117340 29705911
Hypofibrinogenaemia 56.68 10.09 51 129176 1594 29821657
Dyspnoea 56.51 10.09 1056 128171 332239 29491012
Candida infection 56.45 10.09 170 129057 15192 29808059
Inappropriate schedule of product administration 56.25 10.09 53 129174 39675 29783576
Polyomavirus-associated nephropathy 56.10 10.09 69 129158 3116 29820135
Eosinophilia 55.71 10.09 216 129011 21944 29801307
Psoriasis 55.30 10.09 61 129166 42445 29780806
Dermatitis exfoliative 55.00 10.09 108 129119 7348 29815903
Cryptococcosis 54.60 10.09 52 129175 1750 29821501
BK virus infection 54.58 10.09 80 129147 4284 29818967
Squamous cell carcinoma of skin 53.40 10.09 120 129107 8975 29814276
Malaise 53.40 10.09 462 128765 166500 29656751
Drug hypersensitivity 52.87 10.09 489 128738 68030 29755221
Human herpesvirus 6 infection 52.79 10.09 53 129174 1905 29821346
Renal tubular necrosis 51.61 10.09 164 129063 15087 29808164
Suicidal ideation 51.34 10.09 48 129179 36066 29787185
Acute generalised exanthematous pustulosis 50.76 10.09 93 129134 6005 29817246
Cardiac arrest 50.69 10.09 217 129010 92633 29730618
Infection reactivation 50.66 10.09 38 129189 914 29822337
Tumour lysis syndrome 50.60 10.09 146 129081 12739 29810512
Plasma cell myeloma 50.43 10.09 399 128828 53063 29770188
Joint swelling 50.17 10.09 78 129149 46868 29776383
Toxoplasmosis 49.73 10.09 39 129188 1004 29822247
Neuroleptic malignant syndrome 49.55 10.09 6 129221 16289 29806962
Renal tubular acidosis 48.53 10.09 49 129178 1773 29821478
Delayed graft function 48.36 10.09 48 129179 1701 29821550
Pneumonia fungal 48.11 10.09 86 129141 5447 29817804
Sedation 47.47 10.09 7 129220 16366 29806885
Cardio-respiratory arrest 47.42 10.09 111 129116 57195 29766056
Wrong technique in product usage process 47.19 10.09 39 129188 31116 29792135
Encephalitis viral 46.97 10.09 40 129187 1160 29822091
Bradycardia 46.54 10.09 137 129090 65389 29757862
Cystitis haemorrhagic 46.32 10.09 78 129149 4709 29818542
Gait disturbance 45.75 10.09 167 129060 74610 29748641
Vanishing bile duct syndrome 45.53 10.09 31 129196 637 29822614
Strongyloidiasis 44.88 10.09 53 129174 2293 29820958
Immunosuppressant drug level increased 44.68 10.09 76 129151 4626 29818625
Drug dependence 44.56 10.09 18 129209 21277 29801974
Product quality issue 44.23 10.09 13 129214 18761 29804490
Complications of transplanted kidney 43.98 10.09 70 129157 4031 29819220
Transaminases increased 43.82 10.09 209 129018 23248 29800003
Pulmonary nocardiosis 43.62 10.09 25 129202 374 29822877
Enterococcal infection 43.34 10.09 104 129123 8120 29815131
Adenovirus infection 43.24 10.09 71 129156 4197 29819054
Cytomegalovirus test positive 42.98 10.09 65 129162 3580 29819671
Agitation 42.95 10.09 107 129120 53966 29769285
Hyperhidrosis 42.93 10.09 147 129080 66943 29756308
Chest discomfort 42.72 10.09 82 129145 45398 29777853
Drug withdrawal syndrome 42.68 10.09 16 129211 19793 29803458
Intentional product misuse 42.67 10.09 52 129175 34615 29788636
Rhinovirus infection 42.03 10.09 57 129170 2838 29820413
Mycobacterium avium complex infection 41.85 10.09 55 129172 2656 29820595
Injury 41.36 10.09 21 129206 21710 29801541
Insomnia 41.23 10.09 235 128992 93101 29730150
Microsporidia infection 41.09 10.09 28 129199 576 29822675
Hepatitis cholestatic 40.89 10.09 99 129128 7773 29815478
Musculoskeletal stiffness 40.89 10.09 57 129170 35824 29787427
Multiple organ dysfunction syndrome 40.68 10.09 436 128791 63051 29760200
Aplastic anaemia 40.40 10.09 80 129147 5476 29817775
Alanine aminotransferase increased 40.37 10.09 494 128733 73782 29749469
Weight increased 40.32 10.09 176 129051 74737 29748514
Back pain 40.28 10.09 268 128959 102328 29720923
Hypogammaglobulinaemia 39.86 10.09 77 129150 5175 29818076
Stress 39.35 10.09 19 129208 20216 29803035
Liver transplant rejection 39.33 10.09 48 129179 2150 29821101
Chronic obstructive pulmonary disease 39.25 10.09 88 129139 46038 29777213
Hepatic function abnormal 38.98 10.09 312 128915 41633 29781618
Mucormycosis 38.48 10.09 76 129151 5192 29818059
Face oedema 38.46 10.09 122 129105 11212 29812039
Pneumonia bacterial 38.33 10.09 108 129119 9295 29813956
Tubulointerstitial nephritis 38.33 10.09 166 129061 17725 29805526
Transplant dysfunction 38.31 10.09 49 129178 2303 29820948
Respiratory arrest 38.04 10.09 42 129185 29216 29794035
Dysplastic naevus 37.87 10.09 22 129205 338 29822913
Lymphadenopathy 37.03 10.09 205 129022 24171 29799080
Respiratory failure 36.99 10.09 625 128602 100017 29723234
Device related infection 36.55 10.09 158 129069 16857 29806394
Photodermatosis 36.52 10.09 23 129204 412 29822839
Autoimmune haemolytic anaemia 36.46 10.09 64 129163 3995 29819256
Trichophytosis 35.68 10.09 20 129207 286 29822965
Parainfluenzae virus infection 35.65 10.09 44 129183 1994 29821257
Blood urea increased 34.57 10.09 243 128984 31138 29792113
Gamma-glutamyltransferase increased 34.54 10.09 231 128996 29119 29794132
Headache 34.49 10.09 566 128661 181740 29641511
Contusion 34.35 10.09 51 129176 31229 29792022
Solar lentigo 33.72 10.09 20 129207 320 29822931
Sopor 33.54 10.09 4 129223 10987 29812264
Mucosal inflammation 33.51 10.09 236 128991 30258 29792993
Gastrointestinal haemorrhage 33.24 10.09 217 129010 83229 29740022
Hypoalbuminaemia 32.83 10.09 114 129113 10978 29812273
Cardiac disorder 32.42 10.09 78 129149 39815 29783436
Haemolytic anaemia 32.38 10.09 106 129121 9904 29813347
Haematochezia 31.88 10.09 62 129165 34160 29789091
Asthenia 31.78 10.09 720 128507 220570 29602681
Hallucination 31.71 10.09 107 129120 48952 29774299
Jarisch-Herxheimer reaction 31.64 10.09 21 129206 413 29822838
Blood creatine phosphokinase increased 31.62 10.09 91 129136 43757 29779494
Asthma 31.61 10.09 68 129159 36106 29787145
Paracoccidioides infection 31.58 10.09 13 129214 88 29823163
Lymphocele 31.33 10.09 35 129192 1425 29821826
Actinic keratosis 31.32 10.09 56 129171 3547 29819704
Post transplant lymphoproliferative disorder 31.14 10.09 70 129157 5236 29818015
Pneumonia pseudomonal 31.00 10.09 55 129172 3463 29819788
Sleep disorder 30.89 10.09 36 129191 24443 29798808
Medication error 30.85 10.09 27 129200 20945 29802306
Muscle rigidity 30.66 10.09 4 129223 10257 29812994
Hypertriglyceridaemia 30.11 10.09 90 129137 8008 29815243
Reticulocytosis 29.97 10.09 18 129209 295 29822956
Memory impairment 29.95 10.09 73 129154 37101 29786150
Erectile dysfunction 29.53 10.09 21 129206 18081 29805170
Palpitations 29.42 10.09 63 129164 33510 29789741
Birth mark 29.28 10.09 16 129211 217 29823034
Hyperferritinaemia 29.24 10.09 19 129208 360 29822891
Rhabdomyolysis 29.20 10.09 158 129069 63422 29759829
Microangiopathic haemolytic anaemia 29.15 10.09 26 129201 803 29822448
Drug-induced liver injury 29.10 10.09 174 129053 21100 29802151
Fusarium infection 29.05 10.09 29 129198 1035 29822216
Immune effector cell-associated neurotoxicity syndrome 28.44 10.09 26 129201 830 29822421
Therapeutic product effect incomplete 28.41 10.09 65 129162 33769 29789482
Fear 28.40 10.09 6 129221 10819 29812432
Infection 28.36 10.09 484 128743 77590 29745661
Hyperuricaemia 28.28 10.09 83 129144 7311 29815940
Neuropathy peripheral 28.24 10.09 444 128783 70031 29753220
Fungal skin infection 28.15 10.09 43 129184 2389 29820862
Cytomegalovirus enteritis 28.13 10.09 19 129208 385 29822866
Hypotension 28.10 10.09 655 128572 199910 29623341
Extrapyramidal disorder 27.90 10.09 6 129221 10687 29812564
Blood glucose increased 27.66 10.09 154 129073 61376 29761875
Liver disorder 27.56 10.09 221 129006 29501 29793750
Cytomegalovirus colitis 27.45 10.09 42 129185 2337 29820914
Unresponsive to stimuli 27.18 10.09 45 129182 26374 29796877
Aspartate aminotransferase increased 27.11 10.09 404 128823 63018 29760233
Oral candidiasis 27.08 10.09 107 129120 10964 29812287
Depressed level of consciousness 27.07 10.09 80 129147 38142 29785109
Klebsiella infection 27.00 10.09 78 129149 6809 29816442
Progressive multifocal leukoencephalopathy 26.99 10.09 93 129134 8920 29814331
Hyperleukocytosis 26.96 10.09 34 129193 1575 29821676
Hepatomegaly 26.95 10.09 100 129127 9947 29813304
Crystalluria 26.64 10.09 18 129209 365 29822886
Disseminated cryptococcosis 26.63 10.09 27 129200 982 29822269
Abdominal discomfort 26.62 10.09 114 129113 48677 29774574
Poisoning 26.60 10.09 8 129219 11374 29811877
Epidermal necrosis 26.40 10.09 19 129208 428 29822823
Blood immunoglobulin G decreased 26.37 10.09 26 129201 914 29822337
Pyelonephritis 25.83 10.09 66 129161 5360 29817891
Serum sickness 25.62 10.09 35 129192 1755 29821496
Hypertension 25.56 10.09 369 128858 120985 29702266
Balance disorder 25.39 10.09 77 129150 36416 29786835
Idiopathic pulmonary fibrosis 25.37 10.09 55 129172 4014 29819237
Osteoarthritis 25.36 10.09 25 129202 18324 29804927
Flushing 25.30 10.09 56 129171 29436 29793815
Blood fibrinogen decreased 25.26 10.09 26 129201 963 29822288
Renal impairment 25.06 10.09 506 128721 83678 29739573
Pre-engraftment immune reaction 25.06 10.09 11 129216 89 29823162
Upper respiratory tract inflammation 25.00 10.09 35 129192 1796 29821455
Purpura 24.92 10.09 97 129130 9870 29813381
Dyspepsia 24.88 10.09 59 129168 30270 29792981
Rash erythematous 24.81 10.09 174 129053 22278 29800973
Lung transplant rejection 24.78 10.09 23 129204 749 29822502
Myocardial ischaemia 24.63 10.09 23 129204 17294 29805957
Arthropathy 24.55 10.09 32 129195 20695 29802556
Pneumonia pneumococcal 24.48 10.09 35 129192 1832 29821419
Aplasia pure red cell 24.30 10.09 66 129161 5560 29817691
Rectal haemorrhage 24.11 10.09 74 129153 34865 29788386
Vision blurred 23.87 10.09 96 129131 41720 29781531
Depressed mood 23.77 10.09 23 129204 17006 29806245
Brain abscess 23.73 10.09 42 129185 2639 29820612
Bacteraemia 23.73 10.09 131 129096 15429 29807822
C-reactive protein increased 23.54 10.09 289 128938 43184 29780067
Genital erythema 23.17 10.09 12 129215 145 29823106
Cytomegalovirus enterocolitis 23.13 10.09 23 129204 817 29822434
Drug eruption 23.12 10.09 142 129085 17384 29805867
Multiple sclerosis relapse 23.02 10.09 9 129218 10853 29812398
Clear cell renal cell carcinoma 22.92 10.09 24 129203 907 29822344
Acanthamoeba infection 22.76 10.09 18 129209 469 29822782
Erythema multiforme 22.71 10.09 81 129146 7904 29815347
Liver transplant 22.40 10.09 42 129185 2760 29820491
Organising pneumonia 22.39 10.09 60 129167 5014 29818237
Pneumonia influenzal 22.38 10.09 28 129199 1287 29821964
Photosensitivity reaction 22.36 10.09 92 129135 9602 29813649
Transient ischaemic attack 22.32 10.09 47 129180 25153 29798098
Nephropathy toxic 22.24 10.09 98 129129 10541 29812710
Graft versus host disease in skin 22.12 10.09 46 129181 3261 29819990
Isosporiasis 22.06 10.09 10 129217 88 29823163
Type 2 diabetes mellitus 21.96 10.09 16 129211 13606 29809645
Product substitution issue 21.79 10.09 8 129219 10027 29813224
Coma 21.77 10.09 95 129132 40354 29782897
Intentional self-injury 21.68 10.09 16 129211 13516 29809735
Cerebral aspergillosis 21.66 10.09 28 129199 1330 29821921
Glycosylated haemoglobin increased 21.59 10.09 7 129220 9484 29813767
Hyperbilirubinaemia 21.55 10.09 136 129091 16806 29806445
Granuloma skin 21.42 10.09 14 129213 268 29822983
Mental disorder 21.42 10.09 16 129211 13433 29809818
Pericarditis fungal 21.38 10.09 12 129215 172 29823079
Neck pain 21.24 10.09 36 129191 20908 29802343
Obliterative bronchiolitis 21.17 10.09 26 129201 1172 29822079
Pseudomonal bacteraemia 21.17 10.09 22 129205 824 29822427
Weight decreased 21.08 10.09 493 128734 150428 29672823
Drug resistance 21.07 10.09 154 129073 19979 29803272
Vogt-Koyanagi-Harada disease 21.03 10.09 9 129218 68 29823183
Diffuse large B-cell lymphoma 21.00 10.09 78 129149 7763 29815488
Arteriosclerosis coronary artery 20.97 10.09 11 129216 11165 29812086
Herpes simplex 20.94 10.09 54 129173 4410 29818841
Coronary artery occlusion 20.90 10.09 11 129216 11146 29812105
Oesophageal candidiasis 20.86 10.09 52 129175 4158 29819093
Cheilitis 20.82 10.09 36 129191 2220 29821031
Serotonin syndrome 20.81 10.09 28 129199 17863 29805388
Hepatosplenomegaly 20.80 10.09 48 129179 3653 29819598
Road traffic accident 20.59 10.09 26 129201 17045 29806206
Granuloma 20.57 10.09 37 129190 2355 29820896
Blood antidiuretic hormone increased 20.48 10.09 9 129218 73 29823178
Demodicidosis 20.47 10.09 11 129216 144 29823107
Accidental exposure to product 20.44 10.09 9 129218 10106 29813145
Substance abuse 20.43 10.09 3 129224 7037 29816214
Gastroenteritis cryptosporidial 20.40 10.09 12 129215 189 29823062
Aphthous ulcer 20.37 10.09 51 129176 4090 29819161
Pneumocystis jirovecii infection 20.32 10.09 27 129200 1318 29821933
Device malfunction 20.27 10.09 5 129222 8106 29815145
Necrotising retinitis 20.24 10.09 20 129207 705 29822546
Kidney fibrosis 20.21 10.09 34 129193 2051 29821200
Cytomegalovirus chorioretinitis 20.18 10.09 44 129183 3224 29820027
Conjunctivalisation 20.16 10.09 6 129221 12 29823239
Hepatitis fulminant 19.87 10.09 49 129178 3892 29819359
Escherichia urinary tract infection 19.87 10.09 41 129186 2891 29820360
Acquired immunodeficiency syndrome 19.84 10.09 17 129210 497 29822754
Oroantral fistula 19.79 10.09 13 129214 251 29823000
Migraine 19.64 10.09 16 129211 12858 29810393
Meningitis cryptococcal 19.61 10.09 33 129194 1991 29821260
Acute graft versus host disease in skin 19.53 10.09 53 129174 4463 29818788
Scopulariopsis infection 19.52 10.09 10 129217 118 29823133
Head injury 19.43 10.09 27 129200 16993 29806258
Injection site bruising 19.39 10.09 4 129223 7334 29815917
Angina unstable 19.15 10.09 15 129212 12295 29810956
Muscle spasms 19.12 10.09 183 129044 64655 29758596
Dyskinesia 19.11 10.09 41 129186 21793 29801458
Disseminated intravascular coagulation 19.02 10.09 162 129065 22009 29801242
Parvovirus infection 19.02 10.09 16 129211 456 29822795
Sleep apnoea syndrome 18.98 10.09 27 129200 16830 29806421
Renal tubular disorder 18.96 10.09 56 129171 4950 29818301
Pulmonary alveolar haemorrhage 18.92 10.09 67 129160 6514 29816737
Splenomegaly 18.92 10.09 111 129116 13369 29809882
Granulomatous dermatitis 18.81 10.09 12 129215 220 29823031
Bicytopenia 18.79 10.09 30 129197 1732 29821519
Cytopenia 18.76 10.09 78 129149 8178 29815073
Unevaluable event 18.76 10.09 72 129155 31713 29791538
Pneumonitis 18.73 10.09 191 129036 27263 29795988
Restlessness 18.50 10.09 44 129183 22555 29800696
Gastrooesophageal reflux disease 18.44 10.09 74 129153 32181 29791070
Confusional state 18.39 10.09 442 128785 134392 29688859
Immune reconstitution inflammatory syndrome associated tuberculosis 18.36 10.09 15 129212 410 29822841
Schizophrenia 18.36 10.09 8 129219 9040 29814211
Escherichia infection 18.24 10.09 65 129162 6340 29816911
Proteus infection 18.17 10.09 19 129208 717 29822534
Delusion 18.16 10.09 15 129212 11974 29811277
Nephrogenic diabetes insipidus 18.10 10.09 24 129203 1169 29822082
Epstein-Barr viraemia 18.03 10.09 21 129206 895 29822356
Cytomegalovirus infection reactivation 18.01 10.09 29 129198 1686 29821565
Anger 18.01 10.09 13 129214 11107 29812144
Klebsiella sepsis 17.99 10.09 29 129198 1688 29821563
Pulmonary mucormycosis 17.94 10.09 15 129212 424 29822827
Incorrect dose administered 17.92 10.09 73 129154 31613 29791638
Polyomavirus viraemia 17.89 10.09 16 129211 496 29822755
Enterovirus infection 17.88 10.09 17 129210 571 29822680
Abnormal behaviour 17.87 10.09 54 129173 25569 29797682
Blood HIV RNULL increased 17.77 10.09 26 129201 1390 29821861
Paranoia 17.72 10.09 11 129216 10177 29813074
Product prescribing error 17.68 10.09 28 129199 16705 29806546
Tumour flare 17.57 10.09 16 129211 508 29822743
Musculoskeletal discomfort 17.57 10.09 3 129224 6297 29816954
Meningitis aseptic 17.57 10.09 34 129193 2288 29820963
Hypersensitivity myocarditis 17.49 10.09 8 129219 72 29823179
Lymphoproliferative disorder 17.49 10.09 34 129193 2296 29820955
Protothecosis 17.44 10.09 7 129220 44 29823207
Tooth deposit 17.43 10.09 9 129218 108 29823143
Nasopharyngitis 17.39 10.09 166 129061 58683 29764568
Lung infiltration 17.35 10.09 103 129124 12456 29810795
Arthritis 17.32 10.09 51 129176 24350 29798901
Peripheral swelling 17.32 10.09 174 129053 60900 29762351
Fungaemia 17.29 10.09 33 129194 2198 29821053
Staphylococcal infection 17.27 10.09 203 129024 30021 29793230
Encephalitis 17.21 10.09 64 129163 6372 29816879
Enterococcal sepsis 17.14 10.09 27 129200 1541 29821710
Arteriosclerosis 17.11 10.09 13 129214 10820 29812431
Pseudomembranous colitis 17.01 10.09 38 129189 2830 29820421
Cerebral toxoplasmosis 17 10.09 26 129201 1446 29821805
Hypercalcaemia 16.96 10.09 102 129125 12393 29810858
Infective thrombosis 16.85 10.09 8 129219 79 29823172
Haemorrhage 16.77 10.09 123 129104 45956 29777295
Hypoxia 16.77 10.09 295 128932 47559 29775692
CD4 lymphocytes increased 16.76 10.09 12 129215 268 29822983
Achromobacter infection 16.57 10.09 7 129220 51 29823200
Conjunctival irritation 16.54 10.09 9 129218 121 29823130
Myalgia 16.52 10.09 232 128995 76435 29746816
Lung disorder 16.52 10.09 208 129019 31261 29791990
Blood pressure decreased 16.50 10.09 127 129100 46948 29776303
Chronic graft versus host disease 16.49 10.09 47 129180 4072 29819179
Fracture 16.45 10.09 3 129224 6003 29817248
Sphincter of Oddi dysfunction 16.35 10.09 9 129218 124 29823127
Chills 16.27 10.09 418 128809 71920 29751331
Dermatophytosis 16.24 10.09 11 129216 224 29823027
Cardiovascular disorder 16.23 10.09 14 129213 10938 29812313
Swelling 16.18 10.09 90 129137 35885 29787366
Respiratory tract infection fungal 16.16 10.09 17 129210 646 29822605
Mantle cell lymphoma 16.11 10.09 26 129201 1515 29821736
Clostridium difficile infection 16.10 10.09 120 129107 15663 29807588
Poikiloderma 16.08 10.09 10 129217 175 29823076
Polymyositis 16.07 10.09 25 129202 1411 29821840
Pulmonary sarcoidosis 16.05 10.09 16 129211 570 29822681
Folliculitis 16.02 10.09 43 129184 3597 29819654
Disseminated trichosporonosis 16.01 10.09 7 129220 56 29823195
Fungal infection 15.97 10.09 107 129120 13493 29809758
Skull malformation 15.95 10.09 13 129214 354 29822897
HIV infection 15.90 10.09 27 129200 1641 29821610
Respiratory tract infection 15.87 10.09 118 129109 15388 29807863
Rash pruritic 15.86 10.09 158 129069 22414 29800837
Leukaemia recurrent 15.86 10.09 26 129201 1535 29821716
Injection site haemorrhage 15.85 10.09 7 129220 7848 29815403
Injection site erythema 15.73 10.09 22 129205 13812 29809439
Neurotoxicity 15.65 10.09 104 129123 13078 29810173
Klebsiella bacteraemia 15.63 10.09 21 129206 1036 29822215
Escherichia bacteraemia 15.61 10.09 37 129190 2865 29820386
Palmar-plantar erythrodysaesthesia syndrome 15.60 10.09 25 129202 14845 29808406
Visual impairment 15.47 10.09 73 129154 30365 29792886
Escherichia sepsis 15.43 10.09 45 129182 3949 29819302
Acute graft versus host disease 15.42 10.09 58 129169 5806 29817445
Vascular pseudoaneurysm thrombosis 15.40 10.09 7 129220 62 29823189
Interstitial lung disease 15.39 10.09 354 128873 59843 29763408
Serum ferritin increased 15.33 10.09 55 129172 5382 29817869
Lymphadenitis 15.29 10.09 27 129200 1693 29821558
Bacterial infection 15.29 10.09 100 129127 12510 29810741
Mycobacterial infection 15.28 10.09 27 129200 1694 29821557
Atypical mycobacterial infection 15.22 10.09 18 129209 780 29822471
Gastritis fungal 15.21 10.09 8 129219 100 29823151
Lethargy 15.11 10.09 104 129123 39415 29783836
Joint stiffness 15.08 10.09 11 129216 9350 29813901
Haematemesis 15.05 10.09 60 129167 26143 29797108
Lichenoid keratosis 15.04 10.09 30 129197 2064 29821187
Chronic papillomatous dermatitis 15.02 10.09 7 129220 66 29823185
Platelet transfusion 15.02 10.09 20 129207 978 29822273
Hepatitis A 14.95 10.09 14 129213 461 29822790
Phlebitis infective 14.91 10.09 9 129218 149 29823102
Neutrophilic dermatosis 14.79 10.09 10 129217 203 29823048
Portal fibrosis 14.78 10.09 13 129214 394 29822857
Prostatic specific antigen increased 14.77 10.09 18 129209 11986 29811265
Musculoskeletal pain 14.69 10.09 76 129151 30864 29792387
Mobility decreased 14.64 10.09 60 129167 25939 29797312
Hyperphosphataemia 14.62 10.09 31 129196 2228 29821023
Streptococcal bacteraemia 14.57 10.09 26 129201 1644 29821607
Psychotic disorder 14.54 10.09 46 129181 21469 29801782
Haptoglobin decreased 14.50 10.09 15 129212 559 29822692
Immunodeficiency common variable 14.45 10.09 9 129218 158 29823093
Paradoxical drug reaction 14.39 10.09 34 129193 2628 29820623
Osteoporotic fracture 14.33 10.09 20 129207 1023 29822228
Anal inflammation 14.32 10.09 12 129215 340 29822911
Emotional distress 14.30 10.09 29 129198 15736 29807515
Cold sweat 14.21 10.09 11 129216 9071 29814180
Asterixis 14.21 10.09 22 129205 1237 29822014
Immunosuppressant drug level decreased 14.21 10.09 22 129205 1237 29822014
Dyspnoea exertional 14.16 10.09 92 129135 35338 29787913
Lower respiratory tract infection fungal 14.13 10.09 15 129212 576 29822675
Differentiation syndrome 14.12 10.09 21 129206 1139 29822112
Faeces discoloured 14.12 10.09 24 129203 13922 29809329
Peritonitis bacterial 14.07 10.09 17 129210 11361 29811890
Cholestatic liver injury 14.07 10.09 25 129202 1576 29821675
Renal tubular atrophy 14.06 10.09 20 129207 1042 29822209
Conjunctivitis 14.02 10.09 70 129157 7930 29815321
Acute respiratory distress syndrome 14.01 10.09 159 129068 23313 29799938
Alcohol abuse 13.97 10.09 3 129224 5350 29817901
Blood bilirubin unconjugated increased 13.96 10.09 16 129211 670 29822581
Coombs direct test positive 13.93 10.09 11 129216 286 29822965
Steroid diabetes 13.92 10.09 22 129205 1259 29821992
Haemoglobinaemia 13.92 10.09 9 129218 169 29823082
Incorrect route of product administration 13.89 10.09 17 129210 11298 29811953
Prescribed overdose 13.87 10.09 10 129217 8551 29814700
Multiple sclerosis 13.86 10.09 7 129220 7260 29815991
Paraspinal abscess 13.86 10.09 7 129220 80 29823171
Postural tremor 13.83 10.09 11 129216 289 29822962
Stenotrophomonas infection 13.81 10.09 25 129202 1599 29821652
Amnesia 13.78 10.09 56 129171 24265 29798986
Irritability 13.74 10.09 52 129175 22998 29800253
Cardiogenic shock 13.67 10.09 33 129194 16828 29806423
Mucosal infection 13.64 10.09 10 129217 232 29823019
Hypoaldosteronism 13.60 10.09 9 129218 176 29823075
Hyponatraemia 13.59 10.09 383 128844 66819 29756432
Pulmonary physical examination abnormal 13.57 10.09 5 129222 24 29823227
Systemic infection 13.51 10.09 16 129211 694 29822557
Subcapsular renal haematoma 13.39 10.09 12 129215 373 29822878
Discomfort 13.37 10.09 26 129201 14330 29808921
Muscle spasticity 13.36 10.09 3 129224 5185 29818066
Dysphonia 13.35 10.09 40 129187 18992 29804259
Sinusitis bacterial 13.30 10.09 11 129216 306 29822945
Injection site swelling 13.28 10.09 11 129216 8769 29814482
Peripheral arterial occlusive disease 13.28 10.09 3 129224 5165 29818086
Pemphigoid 13.27 10.09 8 129219 7520 29815731
Anhedonia 13.27 10.09 10 129217 8359 29814892
Adverse event 13.26 10.09 29 129198 15312 29807939
Graft versus host disease in gastrointestinal tract 13.25 10.09 36 129191 3033 29820218
Blood bilirubin increased 13.25 10.09 227 129000 36409 29786842
Hepatotoxicity 13.23 10.09 128 129099 18017 29805234
Pseudohyponatraemia 13.21 10.09 7 129220 89 29823162
Angina pectoris 13.19 10.09 74 129153 29444 29793807
Bacterial sepsis 13.19 10.09 49 129178 4877 29818374
Polyglandular autoimmune syndrome type III 13.13 10.09 4 129223 9 29823242
Seizure 13.09 10.09 324 128903 98151 29725100
Urinary incontinence 13.07 10.09 34 129193 16906 29806345
Wheezing 13.06 10.09 79 129148 30859 29792392
Distributive shock 13.03 10.09 15 129212 631 29822620
Brief psychotic disorder with marked stressors 12.96 10.09 8 129219 138 29823113
Nightmare 12.96 10.09 20 129207 12056 29811195
Limb discomfort 12.89 10.09 12 129215 9038 29814213
Gastroenteritis adenovirus 12.87 10.09 7 129220 94 29823157
Heart rate increased 12.85 10.09 106 129121 38615 29784636
Pulpitis dental 12.84 10.09 12 129215 394 29822857
Hypertensive emergency 12.84 10.09 17 129210 827 29822424
Peripheral sensory neuropathy 12.83 10.09 55 129172 5846 29817405
Mycobacterium fortuitum infection 12.77 10.09 9 129218 196 29823055
International normalised ratio increased 12.72 10.09 138 129089 47601 29775650
Miosis 12.71 10.09 9 129218 7767 29815484
Sexual dysfunction 12.67 10.09 5 129222 5996 29817255
Mantle cell lymphoma refractory 12.62 10.09 7 129220 98 29823153
Alanine aminotransferase abnormal 12.61 10.09 32 129195 2587 29820664
Therapeutic response decreased 12.61 10.09 58 129169 24291 29798960
Botulism 12.57 10.09 9 129218 201 29823050
Systemic candida 12.52 10.09 33 129194 2731 29820520
Type 3 diabetes mellitus 12.51 10.09 5 129222 31 29823220
Premature baby 12.50 10.09 34 129193 16657 29806594
Mycobacterium abscessus infection 12.45 10.09 14 129213 574 29822677
Product storage error 12.43 10.09 6 129221 6385 29816866
Human ehrlichiosis 12.42 10.09 9 129218 205 29823046
Fixed eruption 12.41 10.09 20 129207 1164 29822087
Lymphocytic infiltration 12.37 10.09 14 129213 578 29822673
Varicella 12.31 10.09 23 129204 1507 29821744
Bladder spasm 12.31 10.09 17 129210 861 29822390
Ischaemic stroke 12.31 10.09 33 129194 16242 29807009
Infective pulmonary exacerbation of cystic fibrosis 12.30 10.09 71 129156 8501 29814750
Dysarthria 12.27 10.09 79 129148 30411 29792840
Asymptomatic COVID-19 12.25 10.09 5 129222 33 29823218
Acute lymphocytic leukaemia recurrent 12.24 10.09 32 129195 2635 29820616
Electrocardiogram T wave peaked 12.21 10.09 13 129214 501 29822750
Peripheral motor neuropathy 12.20 10.09 24 129203 1635 29821616
Prothrombin level abnormal 12.20 10.09 7 129220 105 29823146
Cardiac failure chronic 12.19 10.09 5 129222 5858 29817393
Skin candida 12.17 10.09 13 129214 503 29822748
Urinoma 12.16 10.09 9 129218 212 29823039
Respiratory syncytial virus infection 12.12 10.09 37 129190 3331 29819920
Ischaemic cardiomyopathy 12.11 10.09 6 129221 6291 29816960
Citrobacter infection 12.11 10.09 13 129214 506 29822745
Myelosuppression 12.08 10.09 63 129164 7259 29815992
Pneumatosis intestinalis 12.06 10.09 32 129195 2658 29820593
Salivary hypersecretion 12.05 10.09 9 129218 7557 29815694
High-grade B-cell lymphoma 12.02 10.09 8 129219 158 29823093
Jaundice 12.00 10.09 202 129025 32284 29790967
Babesiosis 12.00 10.09 6 129221 67 29823184
Product complaint 11.99 10.09 5 129222 5801 29817450
Glomerulonephritis rapidly progressive 11.98 10.09 12 129215 430 29822821
Computerised tomogram thorax abnormal 11.93 10.09 15 129212 693 29822558
Hyperpyrexia 11.91 10.09 31 129196 2546 29820705
Middle insomnia 11.88 10.09 5 129222 5768 29817483
Encephalopathy 11.81 10.09 200 129027 32005 29791246
Biopsy liver abnormal 11.81 10.09 8 129219 163 29823088
Hypoglycaemia 11.80 10.09 152 129075 50829 29772422
Priapism 11.70 10.09 3 129224 4740 29818511
Pyelonephritis acute 11.66 10.09 23 129204 1570 29821681
Trichophytic granuloma 11.62 10.09 6 129221 72 29823179
Surgery 11.58 10.09 20 129207 11531 29811720
Gait inability 11.56 10.09 42 129185 18799 29804452
Adenomatous polyposis coli 11.56 10.09 8 129219 169 29823082
Nausea 11.53 10.09 1114 128113 295843 29527408
Pericarditis 11.52 10.09 70 129157 8536 29814715
Cardiac valve vegetation 11.47 10.09 12 129215 453 29822798
Respiratory depression 11.46 10.09 20 129207 11483 29811768
Transplant failure 11.45 10.09 30 129197 2474 29820777
Tuberculosis of central nervous system 11.44 10.09 8 129219 172 29823079
Coronary artery bypass 11.40 10.09 4 129223 5158 29818093
Urine protein/creatinine ratio increased 11.32 10.09 8 129219 175 29823076
Granulomatous rosacea 11.32 10.09 8 129219 175 29823076
Fontanelle depressed 11.28 10.09 3 129224 3 29823248
Erythroblast count increased 11.28 10.09 3 129224 3 29823248
Atypical mycobacterium test positive 11.28 10.09 3 129224 3 29823248
Alcaligenes infection 11.28 10.09 3 129224 3 29823248
Hepatitis E 11.27 10.09 23 129204 1609 29821642
Dementia 11.24 10.09 23 129204 12438 29810813
Speech disorder 11.20 10.09 61 129166 24451 29798800
Reactive gastropathy 11.16 10.09 8 129219 179 29823072
Colitis 11.15 10.09 191 129036 30629 29792622
Panniculitis 11.14 10.09 16 129211 841 29822410
Parkinsonism 11.13 10.09 9 129218 7260 29815991
Optic discs blurred 11.07 10.09 6 129221 80 29823171
Lactic acidosis 11.03 10.09 84 129143 31129 29792122
Blood glucose decreased 11.02 10.09 25 129202 13028 29810223
Mastitis 11.01 10.09 8 129219 183 29823068
Central nervous system infection 10.99 10.09 12 129215 476 29822775
Mania 10.98 10.09 14 129213 9140 29814111
Eye infection fungal 10.92 10.09 10 129217 320 29822931
Muscular weakness 10.90 10.09 201 129026 63444 29759807
Cyclosporidium infection 10.89 10.09 4 129223 19 29823232
Heart rate decreased 10.87 10.09 50 129177 20944 29802307
Skin exfoliation 10.84 10.09 150 129077 23022 29800229
Renal graft infection 10.83 10.09 9 129218 252 29822999
Withdrawal syndrome 10.81 10.09 20 129207 11230 29812021
Akathisia 10.80 10.09 6 129221 5898 29817353
Pneumothorax 10.73 10.09 112 129115 16081 29807170
Limbal stem cell deficiency 10.72 10.09 4 129223 20 29823231
Eschar 10.69 10.09 13 129214 580 29822671
Asphyxia 10.69 10.09 5 129222 5420 29817831
Respiratory syncytial virus test positive 10.68 10.09 9 129218 257 29822994
Brain compression 10.68 10.09 8 129219 192 29823059
T-cell prolymphocytic leukaemia 10.65 10.09 5 129222 48 29823203
No reaction on previous exposure to drug 10.63 10.09 6 129221 87 29823164
Metastases to lung 10.63 10.09 11 129216 7884 29815367
Amyotrophy 10.61 10.09 12 129215 495 29822756
Unmasking of previously unidentified disease 10.60 10.09 13 129214 585 29822666
Immune recovery uveitis 10.56 10.09 4 129223 21 29823230
Swollen tongue 10.55 10.09 26 129201 13166 29810085
Urinary tract infection 10.55 10.09 403 128824 73256 29749995
Dystonia 10.54 10.09 16 129211 9711 29813540
Polyarteritis nodosa 10.54 10.09 9 129218 262 29822989
Cardiomegaly 10.54 10.09 30 129197 14479 29808772
Internal haemorrhage 10.53 10.09 3 129224 4419 29818832
Acinetobacter infection 10.50 10.09 17 129210 993 29822258
Subcutaneous abscess 10.49 10.09 36 129191 3445 29819806
Pain in jaw 10.49 10.09 23 129204 12133 29811118
Bacterial pyelonephritis 10.48 10.09 9 129218 264 29822987
Granulocytopenia 10.45 10.09 7 129220 6219 29817032
Nervousness 10.43 10.09 22 129205 11766 29811485
Skin bacterial infection 10.39 10.09 5 129222 51 29823200
Nephritis 10.39 10.09 26 129201 2084 29821167
Presyncope 10.38 10.09 35 129192 16021 29807230
Septic embolus 10.33 10.09 18 129209 1117 29822134
Hospitalisation 10.31 10.09 132 129095 44187 29779064
Flavobacterium infection 10.28 10.09 6 129221 93 29823158
Mixed liver injury 10.28 10.09 25 129202 1968 29821283
Acute graft versus host disease in intestine 10.17 10.09 28 129199 2377 29820874
Otitis externa 10.17 10.09 17 129210 1020 29822231
Pancreatitis necrotising 10.14 10.09 28 129199 2381 29820870
Peripheral T-cell lymphoma unspecified recurrent 10.14 10.09 5 129222 54 29823197
Hepatitis B antibody positive 10.14 10.09 5 129222 54 29823197

Pharmacologic Action:

SourceCodeDescription
ATC J01EC01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Intermediate-acting sulfonamides
ATC J01EE01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
SULFONAMIDES AND TRIMETHOPRIM
Combinations of sulfonamides and trimethoprim, incl. derivatives
ATC J04AM08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
FDA CS M0020790 Sulfonamides
FDA EPC N0000175504 Sulfonamide Antimicrobial
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:33282 antibacterials
CHEBI has role CHEBI:35441 anti-infective drugs
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:50183 cytochrome p450 inhibitor
CHEBI has role CHEBI:50502 dihydropteroate synthase inhibitor
CHEBI has role CHEBI:53000 epitope function
CHEBI has role CHEBI:74234 7,8-dihydrobiopterin:nadp(+) oxidoreductase
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:88188 allergenic drug
FDA MoA N0000185504 Cytochrome P450 2C9 Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Acute otitis media indication 3110003
Nocardiosis indication 29227009 DOID:2312
Shigellosis indication 36188001
Klebsiella cystitis indication 60867007
Toxoplasmosis indication 187192000 DOID:9965
Chlamydial conjunctivitis indication 231861005 DOID:13800
Escherichia coli urinary tract infection indication 301011002
Proteus urinary tract infection indication 301012009
Bacterial urinary infection indication 312124009
Infective otitis media indication 312218008
Pneumocystosis jiroveci pneumonia indication 415125002 DOID:11339
Acute exacerbation of chronic bronchitis indication 425748003
Streptococcus Pneumoniae Chronic Bronchitis indication
Haemophilus Influenzae Chronic Bronchitis indication
Aerobic Gram-Positive Cocci Infection indication
Pneumocystis Carinii Pneumonia Prevention indication
Aerobic Gram-Negative Bacillary Infection indication
Haemophilus Influenzae Acute Otitis Media indication
Morganella Morganii Urinary Tract Infection indication
Typhoid fever off-label use 4834000 DOID:13258
Infection of skin AND/OR subcutaneous tissue off-label use 19824006
Pertussis off-label use 27836007
Granuloma inguinale off-label use 28867007 DOID:9113
Listeria meningitis off-label use 31568009 DOID:11572
Sinusitis off-label use 36971009
Whipple's disease off-label use 41545003 DOID:8476
Bacterial pneumonia off-label use 53084003 DOID:874
Paracoccidioidomycosis off-label use 59925007 DOID:12662
Cholera off-label use 63650001 DOID:1498
Brucellosis off-label use 75702008 DOID:11077
Paratyphoid fever off-label use 85904008 DOID:3055
Chlamydial infection off-label use 105629000
Infection of bone off-label use 111253001
Meningococcus carrier off-label use 170486006
Lymphogranuloma venereum off-label use 186946009 DOID:13819
Chancroid off-label use 266143009 DOID:13778
Diverticulitis of gastrointestinal tract off-label use 271366000
Bacterial endocarditis off-label use 301183007
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Chronic Bacterial Prostatitis off-label use
Toxoplasmosis Prevention off-label use
Postexposure Plague Prophylaxis off-label use
Diabetic Foot Infection off-label use
Glomerulonephritis contraindication 36171008 DOID:2921
Acute hepatitis contraindication 37871000
Third trimester pregnancy contraindication 41587001
Uremia contraindication 44730006 DOID:4676
Megaloblastic anemia due to folate deficiency contraindication 85649008 DOID:14026
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Folic acid deficiency contraindication 190633005
Disease of liver contraindication 235856003 DOID:409
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Pseudomembranous enterocolitis contraindication 397683000
Porphyria contraindication 418470004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.79 acidic
pKa2 2.08 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Dihydropteroate synthase Enzyme INHIBITOR IC50 5.33 CHEMBL CHEMBL
Bifunctional protein FolC Enzyme WOMBAT-PK
Dihydrofolate reductase Enzyme IC50 7 CHEMBL
Endothelin-1 receptor GPCR IC50 5.40 CHEMBL
Pol polyprotein Enzyme Ki 8 CHEMBL

External reference:

IDSource
4017734 VUID
N0000146102 NUI
D00447 KEGG_DRUG
4017734 VANDF
C0038689 UMLSCUI
CHEBI:9332 CHEBI
08D PDB_CHEM_ID
CHEMBL443 ChEMBL_ID
D013420 MESH_DESCRIPTOR_UI
1386 INN_ID
DB01015 DRUGBANK_ID
JE42381TNV UNII
5329 PUBCHEM_CID
10933 IUPHAR_LIGAND_ID
10180 RXNORM
2035 MMSL
5526 MMSL
d00119 MMSL
002827 NDDF
363528007 SNOMEDCT_US
70047000 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0121-0853 SUSPENSION 200 mg ORAL NDA 28 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 0121-0854 SUSPENSION 200 mg ORAL NDA 28 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0121-4793 SUSPENSION 200 mg ORAL ANDA 28 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0440-2406 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5180 SUSPENSION 200 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0527-5181 SUSPENSION 200 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0615-0170 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0615-8121 TABLET 800 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9503 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 22 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 22 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9514 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 22 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0703-9526 INJECTION, SOLUTION, CONCENTRATE 80 mg INTRAVENOUS ANDA 22 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 0904-2725 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-053 TABLET 800 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-092 TABLET 800 mg ORAL ANDA 25 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-525 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-926 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 10544-940 TABLET 800 mg ORAL ANDA 27 sections
Sulfamethoxazole and Trimethoprim DS HUMAN PRESCRIPTION DRUG LABEL 2 12634-177 TABLET 800 mg ORAL ANDA 21 sections
SULFAMETHOXAZOLE and TRIMETHOPRIM HUMAN PRESCRIPTION DRUG LABEL 2 12634-779 SUSPENSION 200 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 16590-210 TABLET 800 mg ORAL ANDA 29 sections
SULFATRIM HUMAN PRESCRIPTION DRUG LABEL 2 17856-0007 SUSPENSION 200 mg ORAL NDA 21 sections
Sulfamethoxazole and Trimethoprim Human Prescription Drug Label 2 17856-0496 SUSPENSION 200 mg ORAL ANDA 26 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 17856-0823 SUSPENSION 200 mg ORAL ANDA 20 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 17856-5181 SUSPENSION 200 mg ORAL ANDA 21 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 21695-125 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 21695-701 SUSPENSION 200 mg ORAL ANDA 20 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 33261-148 TABLET 800 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 33261-396 TABLET 400 mg ORAL ANDA 13 sections
Sulfamethoxazole and Trimethoprim HUMAN PRESCRIPTION DRUG LABEL 2 42291-758 TABLET 400 mg ORAL ANDA 13 sections