Stem definition | Drug id | CAS RN |
---|---|---|
anti-infectives, sulfonamides | 2514 | 723-46-6 |
Dose | Unit | Route |
---|---|---|
2 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.39 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 14 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 394.82 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.36 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.23 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 9.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 30, 1973 | FDA | MONARCH PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Muscle injury | 1104.19 | 11.97 | 632 | 58841 | 36479 | 50509172 |
Folliculitis | 1092.71 | 11.97 | 640 | 58833 | 38585 | 50507066 |
Sleep disorder due to general medical condition, insomnia type | 1067.40 | 11.97 | 584 | 58889 | 30863 | 50514788 |
Irritable bowel syndrome | 959.57 | 11.97 | 651 | 58822 | 50790 | 50494861 |
Impaired healing | 771.98 | 11.97 | 646 | 58827 | 69140 | 50476511 |
Blister | 706.87 | 11.97 | 671 | 58802 | 84747 | 50460904 |
Gastrointestinal disorder | 677.20 | 11.97 | 686 | 58787 | 93770 | 50451881 |
Stomatitis | 642.22 | 11.97 | 689 | 58784 | 100655 | 50444996 |
Lower respiratory tract infection | 623.99 | 11.97 | 659 | 58814 | 94542 | 50451109 |
Duodenal ulcer perforation | 532.70 | 11.97 | 436 | 59037 | 45175 | 50500476 |
Ill-defined disorder | 531.03 | 11.97 | 470 | 59003 | 54184 | 50491467 |
Helicobacter infection | 510.14 | 11.97 | 441 | 59032 | 49261 | 50496390 |
Infection | 416.70 | 11.97 | 736 | 58737 | 172218 | 50373433 |
Therapeutic product effect decreased | 405.33 | 11.97 | 637 | 58836 | 135413 | 50410238 |
Confusional state | 398.32 | 11.97 | 752 | 58721 | 185176 | 50360475 |
Sinusitis | 371.66 | 11.97 | 695 | 58778 | 169863 | 50375788 |
Pyrexia | 356.15 | 11.97 | 1116 | 58357 | 379087 | 50166564 |
Anti-cyclic citrullinated peptide antibody positive | 345.13 | 11.97 | 420 | 59053 | 70167 | 50475484 |
Pericarditis | 344.52 | 11.97 | 443 | 59030 | 78246 | 50467405 |
Nasopharyngitis | 290.91 | 11.97 | 676 | 58797 | 192251 | 50353400 |
Weight increased | 289.89 | 11.97 | 694 | 58779 | 201197 | 50344454 |
Hypersensitivity | 287.06 | 11.97 | 719 | 58754 | 214442 | 50331209 |
Peripheral swelling | 280.84 | 11.97 | 694 | 58779 | 205242 | 50340409 |
Contusion | 274.41 | 11.97 | 481 | 58992 | 111702 | 50433949 |
Swelling | 272.90 | 11.97 | 676 | 58797 | 200196 | 50345455 |
Synovitis | 254.98 | 11.97 | 493 | 58980 | 123372 | 50422279 |
Hand deformity | 248.10 | 11.97 | 432 | 59041 | 99767 | 50445884 |
Discomfort | 244.95 | 11.97 | 449 | 59024 | 107931 | 50437720 |
Joint swelling | 218.84 | 11.97 | 709 | 58764 | 244577 | 50301074 |
Pruritus | 217.38 | 11.97 | 779 | 58694 | 282789 | 50262862 |
Arthropathy | 206.47 | 11.97 | 524 | 58949 | 157382 | 50388269 |
Glossodynia | 205.59 | 11.97 | 433 | 59040 | 115136 | 50430515 |
Hepatic enzyme increased | 202.03 | 11.97 | 477 | 58996 | 136903 | 50408748 |
Wound | 200.65 | 11.97 | 407 | 59066 | 105387 | 50440264 |
Pemphigus | 196.33 | 11.97 | 435 | 59038 | 119731 | 50425920 |
Infusion related reaction | 163.73 | 11.97 | 504 | 58969 | 169053 | 50376598 |
Systemic lupus erythematosus | 161.71 | 11.97 | 445 | 59028 | 140177 | 50405474 |
Fall | 151.91 | 11.97 | 104 | 59369 | 334828 | 50210823 |
Rash | 146.55 | 11.97 | 946 | 58527 | 436525 | 50109126 |
Product dose omission issue | 146.42 | 11.97 | 21 | 59452 | 183817 | 50361834 |
Death | 129.83 | 11.97 | 115 | 59358 | 325264 | 50220387 |
Dizziness | 112.97 | 11.97 | 145 | 59328 | 346224 | 50199427 |
Toxicity to various agents | 110.33 | 11.97 | 56 | 59417 | 212443 | 50333208 |
Completed suicide | 109.95 | 11.97 | 13 | 59460 | 131876 | 50413775 |
Contraindicated product administered | 109.36 | 11.97 | 404 | 59069 | 148554 | 50397097 |
Off label use | 108.65 | 11.97 | 249 | 59224 | 474177 | 50071474 |
Pain in extremity | 102.25 | 11.97 | 102 | 59371 | 272763 | 50272888 |
Abdominal discomfort | 102.00 | 11.97 | 539 | 58934 | 231102 | 50314549 |
Malaise | 97.92 | 11.97 | 152 | 59321 | 335380 | 50210271 |
Nausea | 97.45 | 11.97 | 463 | 59010 | 704935 | 49840716 |
Pre-engraftment immune reaction | 92.12 | 11.97 | 26 | 59447 | 212 | 50545439 |
Drug intolerance | 89.79 | 11.97 | 500 | 58973 | 218604 | 50327047 |
Headache | 89.08 | 11.97 | 302 | 59171 | 506233 | 50039418 |
Injection site pain | 85.34 | 11.97 | 14 | 59459 | 111010 | 50434641 |
Blood pressure increased | 72.23 | 11.97 | 33 | 59440 | 133099 | 50412552 |
Feeling abnormal | 69.82 | 11.97 | 30 | 59443 | 125462 | 50420189 |
Diarrhoea | 67.38 | 11.97 | 411 | 59062 | 588065 | 49957586 |
Alanine aminotransferase abnormal | 66.59 | 11.97 | 48 | 59425 | 4108 | 50541543 |
Rheumatoid arthritis | 66.24 | 11.97 | 436 | 59037 | 202114 | 50343537 |
Cough | 64.10 | 11.97 | 116 | 59357 | 241148 | 50304503 |
Encephalitis viral | 63.49 | 11.97 | 33 | 59440 | 1564 | 50544087 |
Red blood cell sedimentation rate | 63.44 | 11.97 | 44 | 59429 | 3542 | 50542109 |
Intentional overdose | 60.91 | 11.97 | 3 | 59470 | 62501 | 50483150 |
Arthralgia | 59.94 | 11.97 | 782 | 58691 | 437920 | 50107731 |
Human herpesvirus 6 infection | 55.78 | 11.97 | 36 | 59437 | 2570 | 50543081 |
Therapeutic product effect incomplete | 53.97 | 11.97 | 20 | 59453 | 91495 | 50454156 |
Condition aggravated | 53.51 | 11.97 | 175 | 59298 | 296883 | 50248768 |
Pneumonia | 53.39 | 11.97 | 246 | 59227 | 378155 | 50167496 |
Fear of injection | 50.43 | 11.97 | 48 | 59425 | 6055 | 50539596 |
Injection site erythema | 50.24 | 11.97 | 13 | 59460 | 74923 | 50470728 |
Medication error | 49.33 | 11.97 | 122 | 59351 | 35982 | 50509669 |
Muscle spasms | 49.20 | 11.97 | 45 | 59428 | 125508 | 50420143 |
Alopecia | 48.48 | 11.97 | 470 | 59003 | 244577 | 50301074 |
Drug abuse | 47.22 | 11.97 | 7 | 59466 | 59839 | 50485812 |
Inappropriate schedule of product administration | 47.14 | 11.97 | 13 | 59460 | 71818 | 50473833 |
Injection site reaction | 46.90 | 11.97 | 3 | 59470 | 50029 | 50495622 |
Tongue disorder | 46.85 | 11.97 | 56 | 59417 | 9160 | 50536491 |
Psoriasis | 46.20 | 11.97 | 12 | 59461 | 68988 | 50476663 |
Enthesopathy | 45.57 | 11.97 | 49 | 59424 | 7144 | 50538507 |
Weight decreased | 45.10 | 11.97 | 123 | 59350 | 221122 | 50324529 |
Back pain | 45.10 | 11.97 | 122 | 59351 | 219908 | 50325743 |
Cytomegalovirus infection | 45.08 | 11.97 | 78 | 59395 | 17884 | 50527767 |
Gait disturbance | 44.57 | 11.97 | 67 | 59406 | 149938 | 50395713 |
Depression | 44.38 | 11.97 | 79 | 59394 | 165344 | 50380307 |
Blood parathyroid hormone decreased | 44.26 | 11.97 | 48 | 59425 | 7066 | 50538585 |
Pregnancy | 41.53 | 11.97 | 101 | 59372 | 29476 | 50516175 |
Wrong technique in product usage process | 40.48 | 11.97 | 8 | 59465 | 55502 | 50490149 |
COVID-19 | 40.39 | 11.97 | 4 | 59469 | 46658 | 50498993 |
Dyspnoea | 39.39 | 11.97 | 880 | 58593 | 546728 | 49998923 |
Balance disorder | 39.05 | 11.97 | 17 | 59456 | 70573 | 50475078 |
Panniculitis | 38.91 | 11.97 | 49 | 59424 | 8454 | 50537197 |
Suicide attempt | 38.69 | 11.97 | 7 | 59466 | 51725 | 50493926 |
Visual impairment | 36.89 | 11.97 | 17 | 59456 | 68258 | 50477393 |
Memory impairment | 36.73 | 11.97 | 24 | 59449 | 79336 | 50466315 |
Skin necrosis | 36.64 | 11.97 | 54 | 59419 | 10813 | 50534838 |
Kidney transplant rejection | 36.11 | 11.97 | 33 | 59440 | 3954 | 50541697 |
Myocardial infarction | 35.96 | 11.97 | 31 | 59442 | 88996 | 50456655 |
Intentional product misuse | 35.66 | 11.97 | 6 | 59467 | 46728 | 50498923 |
Constipation | 34.37 | 11.97 | 108 | 59365 | 185600 | 50360051 |
Flushing | 34.22 | 11.97 | 18 | 59455 | 66997 | 50478654 |
Migraine | 33.20 | 11.97 | 24 | 59449 | 75256 | 50470395 |
Maternal exposure timing unspecified | 32.86 | 11.97 | 30 | 59443 | 3590 | 50542061 |
Oropharyngeal pain | 32.78 | 11.97 | 26 | 59447 | 77775 | 50467876 |
Hyperhidrosis | 32.77 | 11.97 | 34 | 59439 | 89392 | 50456259 |
Syncope | 32.57 | 11.97 | 44 | 59429 | 102958 | 50442693 |
Hypertension | 32.34 | 11.97 | 133 | 59340 | 211070 | 50334581 |
Injection site bruising | 32.22 | 11.97 | 3 | 59470 | 36765 | 50508886 |
Tenosynovitis | 32.08 | 11.97 | 50 | 59423 | 10515 | 50535136 |
Therapy non-responder | 31.38 | 11.97 | 131 | 59342 | 50891 | 50494760 |
Influenza | 30.66 | 11.97 | 36 | 59437 | 89502 | 50456149 |
Injection site swelling | 30.50 | 11.97 | 6 | 59467 | 41767 | 50503884 |
Anxiety | 30.32 | 11.97 | 107 | 59366 | 177499 | 50368152 |
Fluid retention | 29.97 | 11.97 | 11 | 59462 | 50638 | 50495013 |
Asthenia | 29.85 | 11.97 | 236 | 59237 | 318806 | 50226845 |
Breast cancer | 29.60 | 11.97 | 7 | 59466 | 42883 | 50502768 |
Suicidal ideation | 29.60 | 11.97 | 14 | 59459 | 55371 | 50490280 |
Cerebrovascular accident | 29.38 | 11.97 | 41 | 59432 | 94639 | 50451012 |
Paraesthesia | 29.12 | 11.97 | 61 | 59412 | 120182 | 50425469 |
Meningoencephalitis herpetic | 28.50 | 11.97 | 17 | 59456 | 1055 | 50544596 |
Loss of consciousness | 27.82 | 11.97 | 50 | 59423 | 104303 | 50441348 |
Granuloma skin | 27.38 | 11.97 | 34 | 59439 | 5784 | 50539867 |
Urinary tract infection | 27.34 | 11.97 | 153 | 59320 | 223867 | 50321784 |
Injection site pruritus | 27.10 | 11.97 | 7 | 59466 | 40404 | 50505247 |
Deafness transitory | 27.09 | 11.97 | 20 | 59453 | 1776 | 50543875 |
Hepatic cytolysis | 26.94 | 11.97 | 40 | 59433 | 8063 | 50537588 |
Depressed mood | 26.79 | 11.97 | 4 | 59469 | 34019 | 50511632 |
Stress | 26.66 | 11.97 | 15 | 59458 | 53778 | 50491873 |
Vomiting | 26.43 | 11.97 | 382 | 59091 | 460376 | 50085275 |
Overdose | 26.39 | 11.97 | 48 | 59425 | 99679 | 50445972 |
Blood creatinine increased | 26.09 | 11.97 | 166 | 59307 | 75994 | 50469657 |
Chest discomfort | 26.02 | 11.97 | 43 | 59430 | 92679 | 50452972 |
Multiple sclerosis relapse | 25.99 | 11.97 | 9 | 59464 | 42955 | 50502696 |
Complications of transplanted kidney | 25.80 | 11.97 | 21 | 59452 | 2152 | 50543499 |
Unevaluable event | 25.62 | 11.97 | 11 | 59462 | 46055 | 50499596 |
Palpitations | 25.45 | 11.97 | 45 | 59428 | 94461 | 50451190 |
Rheumatoid nodule | 25.29 | 11.97 | 50 | 59423 | 12685 | 50532966 |
Cataract | 25.21 | 11.97 | 12 | 59461 | 47288 | 50498363 |
Febrile bone marrow aplasia | 25.19 | 11.97 | 34 | 59439 | 6277 | 50539374 |
Dyspepsia | 25.14 | 11.97 | 30 | 59443 | 74067 | 50471584 |
Blood pressure fluctuation | 24.42 | 11.97 | 6 | 59467 | 35817 | 50509834 |
Maternal exposure during pregnancy | 24.35 | 11.97 | 291 | 59182 | 159487 | 50386164 |
HIV infection | 24.33 | 11.97 | 10 | 59463 | 274 | 50545377 |
Atrial fibrillation | 24.31 | 11.97 | 52 | 59421 | 101693 | 50443958 |
Nasal congestion | 24.28 | 11.97 | 15 | 59458 | 51105 | 50494546 |
Stevens-Johnson syndrome | 24.11 | 11.97 | 68 | 59405 | 21684 | 50523967 |
Myalgia | 23.92 | 11.97 | 71 | 59402 | 124248 | 50421403 |
Deep vein thrombosis postoperative | 23.90 | 11.97 | 18 | 59455 | 1647 | 50544004 |
Hot flush | 23.86 | 11.97 | 11 | 59462 | 44158 | 50501493 |
Hospitalisation | 23.59 | 11.97 | 27 | 59446 | 67910 | 50477741 |
Drug eruption | 23.48 | 11.97 | 71 | 59402 | 23535 | 50522116 |
Haematochezia | 23.03 | 11.97 | 9 | 59464 | 39873 | 50505778 |
Osteoporosis | 22.99 | 11.97 | 12 | 59461 | 44867 | 50500784 |
Cardiac disorder | 22.76 | 11.97 | 11 | 59462 | 42968 | 50502683 |
Femur fracture | 22.40 | 11.97 | 8 | 59465 | 37456 | 50508195 |
Dysphonia | 22.09 | 11.97 | 9 | 59464 | 38883 | 50506768 |
Foetal exposure during pregnancy | 22.05 | 11.97 | 3 | 59470 | 27356 | 50518295 |
Rhinorrhoea | 22.02 | 11.97 | 17 | 59456 | 51566 | 50494085 |
Aspartate aminotransferase increased | 21.96 | 11.97 | 162 | 59311 | 77836 | 50467815 |
Incorrect dose administered | 21.92 | 11.97 | 15 | 59458 | 48399 | 50497252 |
Asthma | 21.90 | 11.97 | 45 | 59428 | 89292 | 50456359 |
Agranulocytosis | 21.84 | 11.97 | 65 | 59408 | 21356 | 50524295 |
Neck pain | 21.70 | 11.97 | 21 | 59452 | 57046 | 50488605 |
Coma | 21.38 | 11.97 | 127 | 59346 | 56752 | 50488899 |
Cardiac failure congestive | 21.11 | 11.97 | 42 | 59431 | 84340 | 50461311 |
Throat irritation | 20.74 | 11.97 | 5 | 59468 | 30234 | 50515417 |
Musculoskeletal pain | 20.69 | 11.97 | 33 | 59440 | 72144 | 50473507 |
Granuloma | 20.66 | 11.97 | 27 | 59446 | 4831 | 50540820 |
No adverse event | 20.37 | 11.97 | 7 | 59466 | 33571 | 50512080 |
Tendonitis | 20.28 | 11.97 | 54 | 59419 | 16651 | 50529000 |
Exposure during pregnancy | 19.92 | 11.97 | 74 | 59399 | 120941 | 50424710 |
Influenza like illness | 19.77 | 11.97 | 23 | 59450 | 57436 | 50488215 |
Injury | 19.54 | 11.97 | 111 | 59362 | 48814 | 50496837 |
Osteoarthritis | 19.08 | 11.97 | 32 | 59441 | 68574 | 50477077 |
Pancytopenia | 19.00 | 11.97 | 166 | 59307 | 83864 | 50461787 |
Dry eye | 18.94 | 11.97 | 7 | 59466 | 32088 | 50513563 |
Heart rate increased | 18.86 | 11.97 | 39 | 59434 | 77211 | 50468440 |
Dry mouth | 18.79 | 11.97 | 23 | 59450 | 56155 | 50489496 |
Oxygen saturation decreased | 18.72 | 11.97 | 36 | 59437 | 73212 | 50472439 |
Vertigo | 18.65 | 11.97 | 20 | 59453 | 51812 | 50493839 |
Acquired immunodeficiency syndrome | 18.60 | 11.97 | 6 | 59467 | 80 | 50545571 |
Full blood count abnormal | 17.85 | 11.97 | 3 | 59470 | 23385 | 50522266 |
Drug hypersensitivity | 17.82 | 11.97 | 403 | 59070 | 250607 | 50295044 |
Pneumonia aspiration | 17.82 | 11.97 | 78 | 59395 | 30926 | 50514725 |
Autoimmune disorder | 17.81 | 11.97 | 28 | 59445 | 5932 | 50539719 |
Product quality issue | 17.76 | 11.97 | 7 | 59466 | 30851 | 50514800 |
Device expulsion | 17.49 | 11.97 | 6 | 59467 | 28816 | 50516835 |
Mobility decreased | 17.37 | 11.97 | 43 | 59430 | 79905 | 50465746 |
Pain in jaw | 17.27 | 11.97 | 12 | 59461 | 38416 | 50507235 |
Alanine aminotransferase increased | 17.19 | 11.97 | 169 | 59304 | 88190 | 50457461 |
Surgery | 17.14 | 11.97 | 7 | 59466 | 30198 | 50515453 |
Hypoaesthesia | 17.14 | 11.97 | 84 | 59389 | 127173 | 50418478 |
Cardio-respiratory arrest | 17.05 | 11.97 | 23 | 59450 | 53869 | 50491782 |
Bradycardia | 17.05 | 11.97 | 31 | 59442 | 64395 | 50481256 |
Transplant rejection | 17.04 | 11.97 | 36 | 59437 | 9573 | 50536078 |
Cytomegalovirus test positive | 17.03 | 11.97 | 18 | 59455 | 2574 | 50543077 |
Bronchitis | 16.94 | 11.97 | 64 | 59409 | 104095 | 50441556 |
Intestinal obstruction | 16.89 | 11.97 | 5 | 59468 | 26378 | 50519273 |
Bacterial sepsis | 16.82 | 11.97 | 21 | 59452 | 3591 | 50542060 |
Abdominal distension | 16.80 | 11.97 | 38 | 59435 | 72865 | 50472786 |
Abdominal pain | 16.80 | 11.97 | 187 | 59286 | 236041 | 50309610 |
Limb discomfort | 16.76 | 11.97 | 4 | 59469 | 24353 | 50521298 |
Vision blurred | 16.54 | 11.97 | 43 | 59430 | 78604 | 50467047 |
Muscular weakness | 16.36 | 11.97 | 57 | 59416 | 94956 | 50450695 |
Toxic epidermal necrolysis | 16.26 | 11.97 | 58 | 59415 | 20934 | 50524717 |
Renal tubular disorder | 16.14 | 11.97 | 17 | 59456 | 2420 | 50543231 |
Sedation | 15.95 | 11.97 | 8 | 59465 | 30602 | 50515049 |
Hypotension | 15.73 | 11.97 | 189 | 59284 | 235280 | 50310371 |
Chemotherapeutic drug level increased | 15.70 | 11.97 | 6 | 59467 | 135 | 50545516 |
Fibromyalgia | 15.48 | 11.97 | 18 | 59455 | 44960 | 50500691 |
Nephrolithiasis | 15.37 | 11.97 | 11 | 59462 | 34682 | 50510969 |
Product prescribing error | 15.32 | 11.97 | 3 | 59470 | 20958 | 50524693 |
Abdominal pain upper | 15.26 | 11.97 | 117 | 59356 | 159192 | 50386459 |
Drug reaction with eosinophilia and systemic symptoms | 15.20 | 11.97 | 70 | 59403 | 28354 | 50517297 |
Dysgeusia | 15.17 | 11.97 | 14 | 59459 | 38902 | 50506749 |
Ulcer | 14.96 | 11.97 | 55 | 59418 | 20145 | 50525506 |
Hypothyroidism | 14.88 | 11.97 | 11 | 59462 | 34114 | 50511537 |
Cognitive disorder | 14.82 | 11.97 | 18 | 59455 | 44105 | 50501546 |
Cholecystitis chronic | 14.63 | 11.97 | 34 | 59439 | 9635 | 50536016 |
Hepatitis fulminant | 14.55 | 11.97 | 18 | 59455 | 3050 | 50542601 |
Anaphylactic shock | 14.49 | 11.97 | 3 | 59470 | 20152 | 50525499 |
Immunosuppressant drug level increased | 14.48 | 11.97 | 18 | 59455 | 3064 | 50542587 |
Functional gastrointestinal disorder | 14.44 | 11.97 | 19 | 59454 | 3423 | 50542228 |
Disease progression | 14.26 | 11.97 | 61 | 59412 | 95805 | 50449846 |
Bronchopulmonary aspergillosis | 14.11 | 11.97 | 29 | 59444 | 7563 | 50538088 |
Drug dependence | 14.09 | 11.97 | 3 | 59470 | 19756 | 50525895 |
Arrhythmia | 14.04 | 11.97 | 11 | 59462 | 33121 | 50512530 |
Oral pain | 13.89 | 11.97 | 6 | 59467 | 25027 | 50520624 |
Chronic obstructive pulmonary disease | 13.88 | 11.97 | 26 | 59447 | 53409 | 50492242 |
Wheezing | 13.77 | 11.97 | 33 | 59440 | 62014 | 50483637 |
Serotonin syndrome | 13.59 | 11.97 | 6 | 59467 | 24707 | 50520944 |
Osteonecrosis of jaw | 13.53 | 11.97 | 11 | 59462 | 32515 | 50513136 |
Herpes zoster | 13.20 | 11.97 | 41 | 59432 | 70745 | 50474906 |
Feeling hot | 13.16 | 11.97 | 16 | 59457 | 39186 | 50506465 |
Upper respiratory tract infection | 13.13 | 11.97 | 37 | 59436 | 65861 | 50479790 |
Dry skin | 13.10 | 11.97 | 19 | 59454 | 43172 | 50502479 |
Purpura senile | 13.06 | 11.97 | 8 | 59465 | 521 | 50545130 |
Joint stiffness | 12.92 | 11.97 | 10 | 59463 | 30298 | 50515353 |
Tarsal tunnel syndrome | 12.92 | 11.97 | 8 | 59465 | 531 | 50545120 |
Drug ineffective | 12.87 | 11.97 | 811 | 58662 | 818522 | 49727129 |
Blood glucose increased | 12.81 | 11.97 | 42 | 59431 | 71282 | 50474369 |
Pneumocystis jirovecii pneumonia | 12.65 | 11.97 | 42 | 59431 | 14621 | 50531030 |
Lung transplant rejection | 12.59 | 11.97 | 9 | 59464 | 760 | 50544891 |
Trimethylaminuria | 12.31 | 11.97 | 5 | 59468 | 133 | 50545518 |
Device dislocation | 12.21 | 11.97 | 5 | 59468 | 21541 | 50524110 |
Diabetic ketoacidosis | 12.17 | 11.97 | 3 | 59470 | 17869 | 50527782 |
Angina pectoris | 12.00 | 11.97 | 8 | 59465 | 26180 | 50519471 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pyrexia | 138.01 | 11.59 | 681 | 33851 | 286941 | 29253054 |
Drug ineffective | 116.15 | 11.59 | 153 | 34379 | 363017 | 29176978 |
Cytomegalovirus infection | 99.50 | 11.59 | 129 | 34403 | 23086 | 29516909 |
Lymphocyte count decreased | 93.60 | 11.59 | 114 | 34418 | 19157 | 29520838 |
Immune reconstitution inflammatory syndrome | 90.18 | 11.59 | 74 | 34458 | 7728 | 29532267 |
Hyperkalaemia | 87.68 | 11.59 | 210 | 34322 | 61182 | 29478813 |
Death | 85.84 | 11.59 | 169 | 34363 | 341915 | 29198080 |
Off label use | 83.11 | 11.59 | 140 | 34392 | 300660 | 29239335 |
Neutropenia | 81.66 | 11.59 | 337 | 34195 | 131374 | 29408621 |
Aspartate aminotransferase increased | 80.70 | 11.59 | 200 | 34332 | 59525 | 29480470 |
Alanine aminotransferase increased | 78.98 | 11.59 | 221 | 34311 | 70723 | 29469272 |
Blood creatinine increased | 77.59 | 11.59 | 247 | 34285 | 84855 | 29455140 |
Pancytopenia | 77.31 | 11.59 | 243 | 34289 | 82925 | 29457070 |
Stevens-Johnson syndrome | 75.94 | 11.59 | 95 | 34437 | 16402 | 29523593 |
Hepatic cytolysis | 73.89 | 11.59 | 68 | 34464 | 8279 | 29531716 |
Transplant rejection | 73.80 | 11.59 | 71 | 34461 | 9141 | 29530854 |
Clear cell renal cell carcinoma | 71.39 | 11.59 | 31 | 34501 | 984 | 29539011 |
Lymphoproliferative disorder | 64.65 | 11.59 | 39 | 34493 | 2488 | 29537507 |
Acute kidney injury | 60.33 | 11.59 | 521 | 34011 | 264746 | 29275249 |
Kidney transplant rejection | 58.03 | 11.59 | 55 | 34477 | 6950 | 29533045 |
Product dose omission issue | 56.41 | 11.59 | 21 | 34511 | 96362 | 29443633 |
Blood urea increased | 49.99 | 11.59 | 105 | 34427 | 28007 | 29511988 |
Pneumocystis jirovecii pneumonia | 49.41 | 11.59 | 78 | 34454 | 16701 | 29523294 |
Renal tubular necrosis | 45.58 | 11.59 | 69 | 34463 | 14246 | 29525749 |
Cytomegalovirus viraemia | 43.76 | 11.59 | 45 | 34487 | 6275 | 29533720 |
Blood lactate dehydrogenase increased | 42.94 | 11.59 | 79 | 34453 | 19130 | 29520865 |
Alanine aminotransferase abnormal | 42.72 | 11.59 | 32 | 34500 | 2925 | 29537070 |
Agranulocytosis | 40.95 | 11.59 | 80 | 34452 | 20260 | 29519735 |
Pre-engraftment immune reaction | 39.23 | 11.59 | 11 | 34521 | 88 | 29539907 |
Tenosynovitis | 38.17 | 11.59 | 33 | 34499 | 3700 | 29536295 |
Fall | 37.35 | 11.59 | 96 | 34436 | 177082 | 29362913 |
Hospitalisation | 36.86 | 11.59 | 5 | 34527 | 45983 | 29494012 |
Rash maculo-papular | 36.71 | 11.59 | 85 | 34447 | 24204 | 29515791 |
Thrombocytopenia | 36.59 | 11.59 | 276 | 34256 | 134547 | 29405448 |
Cholestasis | 36.44 | 11.59 | 83 | 34449 | 23379 | 29516616 |
Leukopenia | 36.30 | 11.59 | 144 | 34388 | 55059 | 29484936 |
Enthesopathy | 36.09 | 11.59 | 32 | 34500 | 3711 | 29536284 |
Product use issue | 35.98 | 11.59 | 8 | 34524 | 51436 | 29488559 |
Tongue disorder | 35.75 | 11.59 | 35 | 34497 | 4601 | 29535394 |
Inappropriate schedule of product administration | 35.26 | 11.59 | 5 | 34527 | 44467 | 29495528 |
Blood bilirubin increased | 35.16 | 11.59 | 103 | 34429 | 33790 | 29506205 |
Hepatitis | 33.93 | 11.59 | 75 | 34457 | 20708 | 29519287 |
Rash | 33.66 | 11.59 | 354 | 34178 | 189465 | 29350530 |
Platelet count decreased | 33.47 | 11.59 | 223 | 34309 | 104449 | 29435546 |
Haemodialysis | 33.15 | 11.59 | 49 | 34483 | 9905 | 29530090 |
Aplasia pure red cell | 32.54 | 11.59 | 36 | 34496 | 5455 | 29534540 |
Toxicity to various agents | 32.23 | 11.59 | 100 | 34432 | 173561 | 29366434 |
Liver transplant rejection | 29.94 | 11.59 | 22 | 34510 | 1952 | 29538043 |
Incision site pain | 29.62 | 11.59 | 21 | 34511 | 1762 | 29538233 |
Toxic skin eruption | 29.61 | 11.59 | 46 | 34486 | 9711 | 29530284 |
Haemoglobin decreased | 28.90 | 11.59 | 221 | 34311 | 108154 | 29431841 |
Foetal exposure during pregnancy | 28.83 | 11.59 | 3 | 34529 | 33864 | 29506131 |
White blood cell count decreased | 28.10 | 11.59 | 180 | 34352 | 83182 | 29456813 |
Encephalitis viral | 27.75 | 11.59 | 17 | 34515 | 1115 | 29538880 |
Sphincter of Oddi dysfunction | 27.50 | 11.59 | 9 | 34523 | 127 | 29539868 |
Osteoporotic fracture | 27.19 | 11.59 | 16 | 34516 | 975 | 29539020 |
HIV infection | 27.08 | 11.59 | 17 | 34515 | 1164 | 29538831 |
Plasma cell myeloma | 27.00 | 11.59 | 100 | 34432 | 37015 | 29502980 |
Fatigue | 26.77 | 11.59 | 239 | 34293 | 316582 | 29223413 |
Red blood cells urine positive | 26.18 | 11.59 | 19 | 34513 | 1654 | 29538341 |
Delayed graft function | 25.95 | 11.59 | 20 | 34512 | 1907 | 29538088 |
Cerebrovascular accident | 25.88 | 11.59 | 31 | 34501 | 76880 | 29463115 |
Blood antidiuretic hormone increased | 25.78 | 11.59 | 7 | 34525 | 49 | 29539946 |
C-reactive protein increased | 25.58 | 11.59 | 111 | 34421 | 44152 | 29495843 |
Intentional overdose | 24.98 | 11.59 | 7 | 34525 | 38521 | 29501474 |
Tendonitis | 24.81 | 11.59 | 38 | 34494 | 7923 | 29532072 |
Granuloma skin | 24.73 | 11.59 | 13 | 34519 | 635 | 29539360 |
Aspergillus infection | 24.26 | 11.59 | 44 | 34488 | 10537 | 29529458 |
Asthma | 24.20 | 11.59 | 5 | 34527 | 33844 | 29506151 |
Dialysis | 24.11 | 11.59 | 43 | 34489 | 10165 | 29529830 |
Pneumonia cytomegaloviral | 24.03 | 11.59 | 22 | 34510 | 2660 | 29537335 |
Therapeutic product effect incomplete | 23.94 | 11.59 | 8 | 34524 | 39297 | 29500698 |
Kaposi's sarcoma | 23.87 | 11.59 | 14 | 34518 | 848 | 29539147 |
Red blood cell sedimentation rate | 23.70 | 11.59 | 12 | 34520 | 542 | 29539453 |
Acquired immunodeficiency syndrome | 23.53 | 11.59 | 11 | 34521 | 416 | 29539579 |
Drug reaction with eosinophilia and systemic symptoms | 23.44 | 11.59 | 79 | 34453 | 27913 | 29512082 |
Graft versus host disease | 23.31 | 11.59 | 41 | 34491 | 9587 | 29530408 |
Peripheral swelling | 23.30 | 11.59 | 24 | 34508 | 63715 | 29476280 |
Hepatitis cholestatic | 23.05 | 11.59 | 34 | 34498 | 6859 | 29533136 |
Lymphocele | 22.85 | 11.59 | 16 | 34516 | 1316 | 29538679 |
Human herpesvirus 6 infection | 22.22 | 11.59 | 18 | 34514 | 1845 | 29538150 |
Neutrophil count decreased | 22.01 | 11.59 | 105 | 34427 | 43462 | 29496533 |
Gamma-glutamyltransferase increased | 21.98 | 11.59 | 75 | 34457 | 26662 | 29513333 |
Blood alkaline phosphatase increased | 21.90 | 11.59 | 78 | 34454 | 28328 | 29511667 |
Panniculitis | 21.73 | 11.59 | 15 | 34517 | 1206 | 29538789 |
Hepatomegaly | 21.68 | 11.59 | 39 | 34493 | 9278 | 29530717 |
Tubulointerstitial nephritis | 21.63 | 11.59 | 57 | 34475 | 17586 | 29522409 |
C-reactive protein abnormal | 21.51 | 11.59 | 32 | 34500 | 6504 | 29533491 |
Dizziness | 21.28 | 11.59 | 132 | 34400 | 189552 | 29350443 |
Dyspnoea | 21.26 | 11.59 | 262 | 34270 | 326470 | 29213525 |
Serum sickness | 20.94 | 11.59 | 17 | 34515 | 1748 | 29538247 |
Weight increased | 20.77 | 11.59 | 36 | 34496 | 76631 | 29463364 |
Syncope | 20.45 | 11.59 | 40 | 34492 | 81331 | 29458664 |
Renal failure | 20.42 | 11.59 | 220 | 34312 | 118379 | 29421616 |
Chronic lymphocytic leukaemia | 20.13 | 11.59 | 23 | 34509 | 3610 | 29536385 |
Culture urine positive | 20.02 | 11.59 | 14 | 34518 | 1149 | 29538846 |
Parvovirus infection | 20.01 | 11.59 | 10 | 34522 | 439 | 29539556 |
Therapeutic product effect decreased | 19.76 | 11.59 | 5 | 34527 | 29446 | 29510549 |
Intentional product misuse | 19.52 | 11.59 | 8 | 34524 | 34653 | 29505342 |
Blood parathyroid hormone decreased | 19.25 | 11.59 | 12 | 34520 | 812 | 29539183 |
Intentional product use issue | 19.23 | 11.59 | 13 | 34519 | 42485 | 29497510 |
Dermatitis exfoliative | 19.09 | 11.59 | 30 | 34502 | 6395 | 29533600 |
Biopsy liver abnormal | 18.77 | 11.59 | 7 | 34525 | 148 | 29539847 |
Enterovirus infection | 18.76 | 11.59 | 11 | 34521 | 666 | 29539329 |
Complications of transplanted kidney | 18.56 | 11.59 | 23 | 34509 | 3931 | 29536064 |
Wrong technique in product usage process | 18.11 | 11.59 | 7 | 34525 | 31421 | 29508574 |
Hepatosplenomegaly | 18.05 | 11.59 | 22 | 34510 | 3695 | 29536300 |
Blood pressure increased | 17.93 | 11.59 | 37 | 34495 | 73766 | 29466229 |
Cytomegalovirus test positive | 17.84 | 11.59 | 21 | 34511 | 3402 | 29536593 |
Joint swelling | 17.78 | 11.59 | 19 | 34513 | 49611 | 29490384 |
Blood immunoglobulin G decreased | 17.77 | 11.59 | 13 | 34519 | 1146 | 29538849 |
Rash morbilliform | 17.71 | 11.59 | 18 | 34514 | 2475 | 29537520 |
Injection site pain | 17.46 | 11.59 | 8 | 34524 | 32438 | 29507557 |
Hepatic steatosis | 17.03 | 11.59 | 47 | 34485 | 14899 | 29525096 |
Protein urine present | 16.93 | 11.59 | 24 | 34508 | 4670 | 29535325 |
Rash pruritic | 16.89 | 11.59 | 61 | 34471 | 22302 | 29517693 |
Culture stool positive | 16.49 | 11.59 | 7 | 34525 | 210 | 29539785 |
Lung infiltration | 16.47 | 11.59 | 40 | 34492 | 11739 | 29528256 |
Vena cava injury | 16.46 | 11.59 | 7 | 34525 | 211 | 29539784 |
Skin exfoliation | 16.45 | 11.59 | 61 | 34471 | 22584 | 29517411 |
Bronchopulmonary aspergillosis | 16.29 | 11.59 | 41 | 34491 | 12303 | 29527692 |
Arthralgia | 16.25 | 11.59 | 96 | 34436 | 139521 | 29400474 |
Lymphadenopathy | 16.17 | 11.59 | 65 | 34467 | 24984 | 29515011 |
Myocardial infarction | 16.16 | 11.59 | 70 | 34462 | 110226 | 29429769 |
SARS-CoV-2 antibody test positive | 16.01 | 11.59 | 7 | 34525 | 226 | 29539769 |
Oesophageal candidiasis | 16.00 | 11.59 | 21 | 34511 | 3800 | 29536195 |
Bone marrow failure | 15.98 | 11.59 | 69 | 34463 | 27380 | 29512615 |
Drug hypersensitivity | 15.77 | 11.59 | 135 | 34397 | 68271 | 29471724 |
Blood potassium increased | 15.64 | 11.59 | 45 | 34487 | 14606 | 29525389 |
Blood albumin decreased | 15.59 | 11.59 | 39 | 34493 | 11656 | 29528339 |
Cellulitis enterococcal | 15.58 | 11.59 | 5 | 34527 | 66 | 29539929 |
Cytomegalovirus chorioretinitis | 15.46 | 11.59 | 19 | 34513 | 3219 | 29536776 |
Renal tubular disorder | 15.33 | 11.59 | 22 | 34510 | 4330 | 29535665 |
Rectal prolapse | 14.99 | 11.59 | 7 | 34525 | 264 | 29539731 |
Leukaemia recurrent | 14.99 | 11.59 | 13 | 34519 | 1464 | 29538531 |
Cystitis haemorrhagic | 14.93 | 11.59 | 23 | 34509 | 4819 | 29535176 |
Erythema infectiosum | 14.90 | 11.59 | 6 | 34526 | 157 | 29539838 |
Suicide attempt | 14.69 | 11.59 | 11 | 34521 | 34099 | 29505896 |
Anaemia | 14.67 | 11.59 | 322 | 34210 | 200629 | 29339366 |
Lymphocytic infiltration | 14.61 | 11.59 | 9 | 34523 | 596 | 29539399 |
Blood culture positive | 14.48 | 11.59 | 22 | 34510 | 4555 | 29535440 |
HIV wasting syndrome | 14.26 | 11.59 | 5 | 34527 | 88 | 29539907 |
Traumatic liver injury | 14.26 | 11.59 | 6 | 34526 | 176 | 29539819 |
Acute graft versus host disease in skin | 14.17 | 11.59 | 22 | 34510 | 4642 | 29535353 |
Somnolence | 14.15 | 11.59 | 59 | 34473 | 93896 | 29446099 |
Mental status changes | 14.04 | 11.59 | 79 | 34453 | 34848 | 29505147 |
Cystic lymphangioma | 13.97 | 11.59 | 3 | 34529 | 6 | 29539989 |
Phlebitis | 13.97 | 11.59 | 19 | 34513 | 3557 | 29536438 |
Light chain analysis decreased | 13.85 | 11.59 | 4 | 34528 | 36 | 29539959 |
Immunosuppressant drug level increased | 13.81 | 11.59 | 22 | 34510 | 4743 | 29535252 |
Mycobacterium avium complex infection | 13.66 | 11.59 | 15 | 34517 | 2254 | 29537741 |
Wound evisceration | 13.57 | 11.59 | 5 | 34527 | 102 | 29539893 |
Intraductal papillary mucinous neoplasm | 13.49 | 11.59 | 7 | 34525 | 333 | 29539662 |
Hepatitis A antibody positive | 13.47 | 11.59 | 4 | 34528 | 40 | 29539955 |
Liver transplant | 13.41 | 11.59 | 15 | 34517 | 2301 | 29537694 |
Febrile neutropenia | 13.21 | 11.59 | 194 | 34338 | 112046 | 29427949 |
Cytomegalovirus test | 13.13 | 11.59 | 4 | 34528 | 44 | 29539951 |
Eosinophilia | 13.12 | 11.59 | 56 | 34476 | 22105 | 29517890 |
Psoriasis | 13.11 | 11.59 | 11 | 34521 | 32216 | 29507779 |
Lymphopenia | 12.96 | 11.59 | 40 | 34492 | 13493 | 29526502 |
Autoimmune haemolytic anaemia | 12.89 | 11.59 | 19 | 34513 | 3829 | 29536166 |
Blood bilirubin unconjugated increased | 12.70 | 11.59 | 8 | 34524 | 551 | 29539444 |
Thrombotic microangiopathy | 12.70 | 11.59 | 30 | 34502 | 8651 | 29531344 |
Stent removal | 12.65 | 11.59 | 3 | 34529 | 11 | 29539984 |
Therapeutic product effect prolonged | 12.64 | 11.59 | 6 | 34526 | 235 | 29539760 |
Feeling abnormal | 12.63 | 11.59 | 28 | 34504 | 54417 | 29485578 |
Enterococcal infection | 12.56 | 11.59 | 29 | 34503 | 8239 | 29531756 |
Idiopathic pneumonia syndrome | 12.52 | 11.59 | 6 | 34526 | 240 | 29539755 |
Hypercalcaemia | 12.49 | 11.59 | 38 | 34494 | 12721 | 29527274 |
Total lung capacity decreased | 12.48 | 11.59 | 8 | 34524 | 568 | 29539427 |
Hepatitis B antibody positive | 12.45 | 11.59 | 4 | 34528 | 53 | 29539942 |
Renal cyst haemorrhage | 12.34 | 11.59 | 7 | 34525 | 398 | 29539597 |
Abdominal wall haemorrhage | 12.30 | 11.59 | 6 | 34526 | 250 | 29539745 |
Contusion | 12.18 | 11.59 | 11 | 34521 | 31084 | 29508911 |
Chills | 12.13 | 11.59 | 132 | 34400 | 71168 | 29468827 |
Acute graft versus host disease in liver | 12.03 | 11.59 | 11 | 34521 | 1327 | 29538668 |
Granulomatous rosacea | 11.97 | 11.59 | 5 | 34527 | 144 | 29539851 |
Transplant dysfunction | 11.95 | 11.59 | 14 | 34518 | 2256 | 29537739 |
Haematocrit decreased | 11.90 | 11.59 | 66 | 34466 | 28956 | 29511039 |
Pyelonephritis acute | 11.67 | 11.59 | 12 | 34520 | 1672 | 29538323 |
Hepatitis C virus test | 11.64 | 11.59 | 4 | 34528 | 66 | 29539929 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Muscle injury | 886.61 | 11.17 | 482 | 72901 | 25955 | 64399394 |
Folliculitis | 839.17 | 11.17 | 486 | 72897 | 29591 | 64395758 |
Sleep disorder due to general medical condition, insomnia type | 804.11 | 11.17 | 451 | 72932 | 25819 | 64399530 |
Irritable bowel syndrome | 759.06 | 11.17 | 493 | 72890 | 36876 | 64388473 |
Impaired healing | 551.83 | 11.17 | 495 | 72888 | 59978 | 64365371 |
Duodenal ulcer perforation | 516.94 | 11.17 | 378 | 73005 | 34247 | 64391102 |
Helicobacter infection | 493.28 | 11.17 | 383 | 73000 | 37979 | 64387370 |
Blister | 482.06 | 11.17 | 525 | 72858 | 80442 | 64344907 |
Gastrointestinal disorder | 441.41 | 11.17 | 527 | 72856 | 89182 | 64336167 |
Stomatitis | 401.11 | 11.17 | 556 | 72827 | 109049 | 64316300 |
Lower respiratory tract infection | 381.21 | 11.17 | 503 | 72880 | 94111 | 64331238 |
Ill-defined disorder | 375.13 | 11.17 | 347 | 73036 | 43705 | 64381644 |
Anti-cyclic citrullinated peptide antibody positive | 371.85 | 11.17 | 364 | 73019 | 49198 | 64376151 |
Pericarditis | 347.18 | 11.17 | 391 | 72992 | 62125 | 64363224 |
Pemphigus | 330.87 | 11.17 | 376 | 73007 | 60325 | 64365024 |
Hand deformity | 315.62 | 11.17 | 373 | 73010 | 62398 | 64362951 |
Glossodynia | 311.43 | 11.17 | 376 | 73007 | 64320 | 64361029 |
Synovitis | 308.90 | 11.17 | 466 | 72917 | 98624 | 64326725 |
Pyrexia | 300.75 | 11.17 | 1343 | 72040 | 557301 | 63868048 |
Infection | 281.51 | 11.17 | 638 | 72745 | 184242 | 64241107 |
Discomfort | 278.98 | 11.17 | 399 | 72984 | 80479 | 64344870 |
Sinusitis | 275.80 | 11.17 | 550 | 72833 | 145378 | 64279971 |
Systemic lupus erythematosus | 273.77 | 11.17 | 387 | 72996 | 77225 | 64348124 |
Therapeutic product effect decreased | 273.22 | 11.17 | 479 | 72904 | 114872 | 64310477 |
Hypersensitivity | 232.04 | 11.17 | 615 | 72768 | 195837 | 64229512 |
Wound | 230.25 | 11.17 | 354 | 73029 | 76123 | 64349226 |
Arthropathy | 228.58 | 11.17 | 456 | 72927 | 120511 | 64304838 |
Swelling | 223.08 | 11.17 | 534 | 72849 | 159684 | 64265665 |
Hepatic enzyme increased | 207.24 | 11.17 | 457 | 72926 | 129486 | 64295863 |
Completed suicide | 201.08 | 11.17 | 14 | 73369 | 224400 | 64200949 |
Death | 191.67 | 11.17 | 161 | 73222 | 482544 | 63942805 |
Contraindicated product administered | 183.07 | 11.17 | 389 | 72994 | 107440 | 64317909 |
Confusional state | 176.99 | 11.17 | 675 | 72708 | 260469 | 64164880 |
Rash | 162.90 | 11.17 | 983 | 72400 | 457566 | 63967783 |
Contusion | 158.68 | 11.17 | 380 | 73003 | 113585 | 64311764 |
Infusion related reaction | 155.18 | 11.17 | 475 | 72908 | 163992 | 64261357 |
Fall | 154.62 | 11.17 | 148 | 73235 | 416678 | 64008671 |
Nasopharyngitis | 151.49 | 11.17 | 529 | 72854 | 195544 | 64229805 |
Product dose omission issue | 149.03 | 11.17 | 22 | 73361 | 194725 | 64230624 |
Joint swelling | 142.78 | 11.17 | 553 | 72830 | 214829 | 64210520 |
Peripheral swelling | 141.92 | 11.17 | 541 | 72842 | 208612 | 64216737 |
Weight increased | 139.98 | 11.17 | 546 | 72837 | 212802 | 64212547 |
Off label use | 135.95 | 11.17 | 327 | 73056 | 632479 | 63792870 |
Toxicity to various agents | 133.68 | 11.17 | 130 | 73253 | 363383 | 64061966 |
Pre-engraftment immune reaction | 132.03 | 11.17 | 37 | 73346 | 304 | 64425045 |
Abdominal discomfort | 130.65 | 11.17 | 480 | 72903 | 181842 | 64243507 |
Pruritus | 122.58 | 11.17 | 688 | 72695 | 311712 | 64113637 |
Drug abuse | 122.27 | 11.17 | 7 | 73376 | 132367 | 64292982 |
Drug intolerance | 120.76 | 11.17 | 478 | 72905 | 187514 | 64237835 |
Alanine aminotransferase abnormal | 113.73 | 11.17 | 80 | 73303 | 6808 | 64418541 |
Dizziness | 101.42 | 11.17 | 211 | 73172 | 429952 | 63995397 |
Alopecia | 96.64 | 11.17 | 409 | 72974 | 165281 | 64260068 |
Encephalitis viral | 95.61 | 11.17 | 49 | 73334 | 2331 | 64423018 |
Red blood cell sedimentation rate | 92.96 | 11.17 | 56 | 73327 | 3658 | 64421691 |
Enthesopathy | 91.97 | 11.17 | 81 | 73302 | 9557 | 64415792 |
Tongue disorder | 89.18 | 11.17 | 88 | 73295 | 11992 | 64413357 |
Injection site pain | 86.56 | 11.17 | 12 | 73371 | 111396 | 64313953 |
Malaise | 86.28 | 11.17 | 203 | 73180 | 396044 | 64029305 |
Rheumatoid arthritis | 84.77 | 11.17 | 391 | 72992 | 163903 | 64261446 |
Cytomegalovirus infection | 82.20 | 11.17 | 150 | 73233 | 37049 | 64388300 |
Tenosynovitis | 81.47 | 11.17 | 83 | 73300 | 11750 | 64413599 |
Human herpesvirus 6 infection | 76.71 | 11.17 | 54 | 73329 | 4600 | 64420749 |
Blood creatinine increased | 73.65 | 11.17 | 328 | 73055 | 135454 | 64289895 |
Kidney transplant rejection | 73.41 | 11.17 | 71 | 73312 | 9440 | 64415909 |
Intentional overdose | 71.51 | 11.17 | 9 | 73374 | 89935 | 64335414 |
Alanine aminotransferase increased | 70.31 | 11.17 | 329 | 73054 | 138702 | 64286647 |
Pain in extremity | 70.23 | 11.17 | 150 | 73233 | 302935 | 64122414 |
Blood pressure increased | 70.21 | 11.17 | 56 | 73327 | 172496 | 64252853 |
Aspartate aminotransferase increased | 67.72 | 11.17 | 293 | 73090 | 119495 | 64305854 |
Inappropriate schedule of product administration | 67.03 | 11.17 | 12 | 73371 | 92274 | 64333075 |
Blood parathyroid hormone decreased | 66.50 | 11.17 | 60 | 73323 | 7306 | 64418043 |
Immune reconstitution inflammatory syndrome | 65.77 | 11.17 | 76 | 73307 | 12394 | 64412955 |
Stevens-Johnson syndrome | 64.45 | 11.17 | 129 | 73254 | 34120 | 64391229 |
Feeling abnormal | 64.24 | 11.17 | 36 | 73347 | 133566 | 64291783 |
Transplant rejection | 63.11 | 11.17 | 88 | 73295 | 17313 | 64408036 |
Panniculitis | 62.44 | 11.17 | 63 | 73320 | 8816 | 64416533 |
Hyperkalaemia | 61.54 | 11.17 | 253 | 73130 | 100876 | 64324473 |
Wrong technique in product usage process | 58.29 | 11.17 | 4 | 73379 | 64970 | 64360379 |
Pregnancy | 56.40 | 11.17 | 92 | 73291 | 20773 | 64404576 |
Intentional product misuse | 55.65 | 11.17 | 8 | 73375 | 72287 | 64353062 |
Tendonitis | 55.60 | 11.17 | 90 | 73293 | 20192 | 64405157 |
Fear of injection | 55.04 | 11.17 | 49 | 73334 | 5863 | 64419486 |
Therapeutic product effect incomplete | 54.06 | 11.17 | 25 | 73358 | 103457 | 64321892 |
Maternal exposure during pregnancy | 53.77 | 11.17 | 234 | 73149 | 95650 | 64329699 |
Clear cell renal cell carcinoma | 52.34 | 11.17 | 32 | 73351 | 2147 | 64423202 |
Granuloma skin | 48.12 | 11.17 | 46 | 73337 | 6028 | 64419321 |
Back pain | 47.60 | 11.17 | 137 | 73246 | 250034 | 64175315 |
Skin necrosis | 46.87 | 11.17 | 69 | 73314 | 14260 | 64411089 |
Headache | 46.73 | 11.17 | 382 | 73001 | 529085 | 63896264 |
Therapy non-responder | 46.69 | 11.17 | 173 | 73210 | 65726 | 64359623 |
Syncope | 46.46 | 11.17 | 67 | 73316 | 157568 | 64267781 |
Lymphoproliferative disorder | 44.96 | 11.17 | 41 | 73342 | 5062 | 64420287 |
Cough | 44.94 | 11.17 | 184 | 73199 | 301964 | 64123385 |
Pancytopenia | 43.68 | 11.17 | 296 | 73087 | 143013 | 64282336 |
Drug hypersensitivity | 43.26 | 11.17 | 437 | 72946 | 237378 | 64187971 |
Rheumatoid nodule | 42.95 | 11.17 | 62 | 73321 | 12589 | 64412760 |
Psoriasis | 42.94 | 11.17 | 14 | 73369 | 71689 | 64353660 |
Cerebrovascular accident | 41.02 | 11.17 | 58 | 73325 | 137525 | 64287824 |
Diarrhoea | 40.58 | 11.17 | 579 | 72804 | 722125 | 63703224 |
Maternal exposure timing unspecified | 39.11 | 11.17 | 29 | 73354 | 2678 | 64422671 |
Suicide attempt | 38.91 | 11.17 | 16 | 73367 | 70991 | 64354358 |
Nausea | 38.55 | 11.17 | 646 | 72737 | 785154 | 63640195 |
Myocardial infarction | 38.41 | 11.17 | 82 | 73301 | 165739 | 64259610 |
Gait disturbance | 38.35 | 11.17 | 87 | 73296 | 172068 | 64253281 |
Hepatic cytolysis | 38.04 | 11.17 | 62 | 73321 | 13987 | 64411362 |
Renal tubular necrosis | 37.73 | 11.17 | 80 | 73303 | 22030 | 64403319 |
Injection site erythema | 37.13 | 11.17 | 17 | 73366 | 70783 | 64354566 |
Balance disorder | 37.02 | 11.17 | 25 | 73358 | 83901 | 64341448 |
Overdose | 36.88 | 11.17 | 79 | 73304 | 159487 | 64265862 |
Cytomegalovirus viraemia | 36.66 | 11.17 | 53 | 73330 | 10775 | 64414574 |
Oropharyngeal pain | 35.93 | 11.17 | 29 | 73354 | 88838 | 64336511 |
Weight decreased | 35.37 | 11.17 | 186 | 73197 | 285553 | 64139796 |
Condition aggravated | 34.52 | 11.17 | 265 | 73118 | 372161 | 64053188 |
Blood urea increased | 33.90 | 11.17 | 119 | 73264 | 44034 | 64381315 |
Nasal congestion | 33.41 | 11.17 | 13 | 73370 | 59645 | 64365704 |
C-reactive protein abnormal | 33.24 | 11.17 | 90 | 73293 | 28957 | 64396392 |
Rhinorrhoea | 32.08 | 11.17 | 14 | 73369 | 59955 | 64365394 |
Constipation | 32.02 | 11.17 | 143 | 73240 | 229194 | 64196155 |
Cardio-respiratory arrest | 31.86 | 11.17 | 39 | 73344 | 98354 | 64326995 |
Drug eruption | 31.82 | 11.17 | 102 | 73281 | 36034 | 64389315 |
Hypertension | 31.40 | 11.17 | 170 | 73213 | 259091 | 64166258 |
Hospitalisation | 31.08 | 11.17 | 24 | 73359 | 75183 | 64350166 |
Pneumocystis jirovecii pneumonia | 31.00 | 11.17 | 85 | 73298 | 27549 | 64397800 |
Memory impairment | 31.00 | 11.17 | 31 | 73352 | 85651 | 64339698 |
Incision site pain | 30.87 | 11.17 | 25 | 73358 | 2629 | 64422720 |
Haemodialysis | 30.55 | 11.17 | 63 | 73320 | 17014 | 64408335 |
Depressed mood | 30.51 | 11.17 | 5 | 73378 | 41007 | 64384342 |
Pneumonia | 30.40 | 11.17 | 451 | 72932 | 559125 | 63866224 |
Meningoencephalitis herpetic | 30.35 | 11.17 | 21 | 73362 | 1740 | 64423609 |
Complications of transplanted kidney | 30.14 | 11.17 | 34 | 73349 | 5401 | 64419948 |
Loss of consciousness | 29.87 | 11.17 | 79 | 73304 | 148286 | 64277063 |
Asthma | 29.53 | 11.17 | 39 | 73344 | 95186 | 64330163 |
Fluid retention | 28.73 | 11.17 | 16 | 73367 | 59590 | 64365759 |
Multiple sclerosis relapse | 28.49 | 11.17 | 6 | 73377 | 41129 | 64384220 |
Muscle spasms | 28.46 | 11.17 | 75 | 73308 | 140948 | 64284401 |
Depression | 28.24 | 11.17 | 110 | 73273 | 183181 | 64242168 |
Injection site reaction | 28.13 | 11.17 | 9 | 73374 | 46655 | 64378694 |
Haematochezia | 27.66 | 11.17 | 21 | 73362 | 66352 | 64358997 |
Agranulocytosis | 27.61 | 11.17 | 101 | 73282 | 38128 | 64387221 |
Cardiac failure congestive | 27.47 | 11.17 | 68 | 73315 | 130512 | 64294837 |
Hypotension | 27.45 | 11.17 | 289 | 73094 | 380685 | 64044664 |
Drug reaction with eosinophilia and systemic symptoms | 27.15 | 11.17 | 128 | 73255 | 54089 | 64371260 |
Influenza | 26.97 | 11.17 | 50 | 73333 | 106481 | 64318868 |
Febrile bone marrow aplasia | 26.93 | 11.17 | 47 | 73336 | 11208 | 64414141 |
Product prescribing error | 26.91 | 11.17 | 4 | 73379 | 35265 | 64390084 |
Serotonin syndrome | 26.66 | 11.17 | 6 | 73377 | 39276 | 64386073 |
COVID-19 | 26.65 | 11.17 | 21 | 73362 | 65119 | 64360230 |
Visual impairment | 26.57 | 11.17 | 27 | 73356 | 74050 | 64351299 |
Drug ineffective | 26.54 | 11.17 | 741 | 72642 | 839506 | 63585843 |
Suicidal ideation | 26.54 | 11.17 | 22 | 73361 | 66520 | 64358829 |
Liver transplant rejection | 26.23 | 11.17 | 24 | 73359 | 2975 | 64422374 |
Granuloma | 26.22 | 11.17 | 35 | 73348 | 6606 | 64418743 |
Cardiac failure | 25.51 | 11.17 | 72 | 73311 | 132301 | 64293048 |
Stress | 25.42 | 11.17 | 19 | 73364 | 60515 | 64364834 |
Blood lactate dehydrogenase increased | 25.26 | 11.17 | 89 | 73294 | 32989 | 64392360 |
Haematemesis | 25.09 | 11.17 | 11 | 73372 | 46988 | 64378361 |
Anxiety | 25.01 | 11.17 | 132 | 73251 | 202517 | 64222832 |
Sedation | 24.99 | 11.17 | 8 | 73375 | 41454 | 64383895 |
Cytomegalovirus test positive | 24.89 | 11.17 | 30 | 73353 | 5114 | 64420235 |
Injection site swelling | 24.89 | 11.17 | 8 | 73375 | 41345 | 64384004 |
Palpitations | 24.75 | 11.17 | 51 | 73332 | 104437 | 64320912 |
Drug interaction | 24.35 | 11.17 | 279 | 73104 | 361804 | 64063545 |
Ulcer | 24.10 | 11.17 | 69 | 73314 | 22921 | 64402428 |
Arthralgia | 23.51 | 11.17 | 664 | 72719 | 441596 | 63983753 |
Chest discomfort | 23.24 | 11.17 | 62 | 73321 | 116044 | 64309305 |
Chronic obstructive pulmonary disease | 23.17 | 11.17 | 28 | 73355 | 71020 | 64354329 |
Serum sickness | 23.11 | 11.17 | 23 | 73360 | 3166 | 64422183 |
Breast cancer | 22.96 | 11.17 | 3 | 73380 | 29145 | 64396204 |
Deep vein thrombosis postoperative | 22.81 | 11.17 | 16 | 73367 | 1355 | 64423994 |
Flushing | 22.60 | 11.17 | 34 | 73349 | 78614 | 64346735 |
Neck pain | 22.56 | 11.17 | 22 | 73361 | 61511 | 64363838 |
Atrial fibrillation | 22.50 | 11.17 | 109 | 73274 | 170980 | 64254369 |
Unevaluable event | 22.32 | 11.17 | 15 | 73368 | 50474 | 64374875 |
Dyspepsia | 21.86 | 11.17 | 36 | 73347 | 80276 | 64345073 |
Hypercalcaemia | 21.85 | 11.17 | 82 | 73301 | 31334 | 64394015 |
Blood pressure fluctuation | 20.87 | 11.17 | 17 | 73366 | 51854 | 64373495 |
Rash pruritic | 20.83 | 11.17 | 124 | 73259 | 57280 | 64368069 |
Bronchopulmonary aspergillosis | 20.71 | 11.17 | 58 | 73325 | 19027 | 64406322 |
Intentional self-injury | 20.60 | 11.17 | 4 | 73379 | 29040 | 64396309 |
Paraesthesia | 20.55 | 11.17 | 81 | 73302 | 134441 | 64290908 |
Delayed graft function | 20.36 | 11.17 | 21 | 73362 | 3015 | 64422334 |
Lymphocyte count decreased | 20.32 | 11.17 | 96 | 73287 | 40603 | 64384746 |
Osteonecrosis of jaw | 20.21 | 11.17 | 10 | 73373 | 39815 | 64385534 |
Hot flush | 20.08 | 11.17 | 14 | 73369 | 46221 | 64379128 |
Liver transplant | 20.02 | 11.17 | 24 | 73359 | 4068 | 64421281 |
Cardiogenic shock | 20.00 | 11.17 | 6 | 73377 | 32421 | 64392928 |
Hyperhidrosis | 19.86 | 11.17 | 74 | 73309 | 124846 | 64300503 |
Pain in jaw | 19.55 | 11.17 | 11 | 73372 | 40744 | 64384605 |
Platelet count decreased | 19.42 | 11.17 | 283 | 73100 | 167428 | 64257921 |
Basal cell carcinoma | 19.41 | 11.17 | 78 | 73305 | 30760 | 64394589 |
Wheezing | 19.36 | 11.17 | 39 | 73344 | 80540 | 64344809 |
Somnolence | 19.26 | 11.17 | 144 | 73239 | 203501 | 64221848 |
Cataract | 19.17 | 11.17 | 18 | 73365 | 51244 | 64374105 |
Blood antidiuretic hormone increased | 19.15 | 11.17 | 6 | 73377 | 75 | 64425274 |
Blood culture positive | 19.01 | 11.17 | 33 | 73350 | 7835 | 64417514 |
Plasma cell myeloma | 19.01 | 11.17 | 103 | 73280 | 45972 | 64379377 |
Asthenia | 18.95 | 11.17 | 358 | 73025 | 427686 | 63997663 |
Dialysis | 18.93 | 11.17 | 52 | 73331 | 16868 | 64408481 |
Limb discomfort | 18.74 | 11.17 | 4 | 73379 | 27171 | 64398178 |
Injection site pruritus | 18.45 | 11.17 | 10 | 73373 | 37816 | 64387533 |
Renal tubular disorder | 18.40 | 11.17 | 28 | 73355 | 5959 | 64419390 |
Blood bilirubin unconjugated increased | 18.35 | 11.17 | 12 | 73371 | 905 | 64424444 |
Acute myocardial infarction | 18.29 | 11.17 | 32 | 73351 | 69686 | 64355663 |
Cardiac disorder | 18.20 | 11.17 | 22 | 73361 | 55794 | 64369555 |
Sphincter of Oddi dysfunction | 18.17 | 11.17 | 9 | 73374 | 398 | 64424951 |
Bradycardia | 18.17 | 11.17 | 71 | 73312 | 118148 | 64307201 |
Cardiac arrest | 18.10 | 11.17 | 102 | 73281 | 153962 | 64271387 |
Incorrect dose administered | 17.72 | 11.17 | 26 | 73357 | 60739 | 64364610 |
Autoimmune disorder | 17.59 | 11.17 | 27 | 73356 | 5789 | 64419560 |
Diabetic ketoacidosis | 17.56 | 11.17 | 6 | 73377 | 29839 | 64395510 |
Product quality issue | 17.52 | 11.17 | 6 | 73377 | 29793 | 64395556 |
Biopsy liver abnormal | 17.43 | 11.17 | 9 | 73374 | 435 | 64424914 |
Influenza like illness | 17.42 | 11.17 | 27 | 73356 | 61675 | 64363674 |
Abdominal pain upper | 17.40 | 11.17 | 122 | 73261 | 174908 | 64250441 |
Muscular weakness | 17.40 | 11.17 | 80 | 73303 | 127258 | 64298091 |
Musculoskeletal pain | 17.35 | 11.17 | 42 | 73341 | 81252 | 64344097 |
Acute kidney injury | 17.25 | 11.17 | 649 | 72734 | 448591 | 63976758 |
Psychotic disorder | 17.07 | 11.17 | 9 | 73374 | 34569 | 64390780 |
Graft versus host disease | 17.02 | 11.17 | 44 | 73339 | 13769 | 64411580 |
Aspergillus infection | 17.01 | 11.17 | 49 | 73334 | 16330 | 64409019 |
Perinephric collection | 17.01 | 11.17 | 8 | 73375 | 315 | 64425034 |
Cytomegalovirus test | 16.97 | 11.17 | 5 | 73378 | 50 | 64425299 |
Cephalhaematoma | 16.90 | 11.17 | 4 | 73379 | 15 | 64425334 |
Ischaemic stroke | 16.81 | 11.17 | 6 | 73377 | 29029 | 64396320 |
Red blood cells urine positive | 16.76 | 11.17 | 23 | 73360 | 4455 | 64420894 |
Rash maculo-papular | 16.69 | 11.17 | 101 | 73282 | 46925 | 64378424 |
Osteoporosis | 16.67 | 11.17 | 14 | 73369 | 42066 | 64383283 |
Dyspnoea exertional | 16.62 | 11.17 | 37 | 73346 | 73693 | 64351656 |
Toxic skin eruption | 16.58 | 11.17 | 54 | 73329 | 19230 | 64406119 |
Culture urine positive | 16.58 | 11.17 | 22 | 73361 | 4129 | 64421220 |
Dysphonia | 16.52 | 11.17 | 17 | 73366 | 46365 | 64378984 |
Acquired immunodeficiency syndrome | 16.45 | 11.17 | 7 | 73376 | 217 | 64425132 |
Gastrointestinal haemorrhage | 16.42 | 11.17 | 86 | 73297 | 132226 | 64293123 |
Aggression | 16.41 | 11.17 | 17 | 73366 | 46215 | 64379134 |
Anaphylactic shock | 16.34 | 11.17 | 7 | 73376 | 30321 | 64395028 |
Vena cava injury | 16.27 | 11.17 | 7 | 73376 | 223 | 64425126 |
Migraine | 16.23 | 11.17 | 29 | 73354 | 62648 | 64362701 |
Autoimmune haemolytic anaemia | 16.22 | 11.17 | 29 | 73354 | 7047 | 64418302 |
Dermatitis exfoliative | 16.00 | 11.17 | 36 | 73347 | 10316 | 64415033 |
Drug dependence | 15.97 | 11.17 | 9 | 73374 | 33303 | 64392046 |
Chronic lymphocytic leukaemia | 15.91 | 11.17 | 22 | 73361 | 4293 | 64421056 |
Blood bilirubin increased | 15.83 | 11.17 | 116 | 73267 | 57437 | 64367912 |
HIV wasting syndrome | 15.78 | 11.17 | 5 | 73378 | 65 | 64425284 |
Lung infiltration | 15.77 | 11.17 | 56 | 73327 | 20833 | 64404516 |
SARS-CoV-2 antibody test positive | 15.73 | 11.17 | 7 | 73376 | 242 | 64425107 |
Labelled drug-drug interaction medication error | 15.73 | 11.17 | 3 | 73380 | 22059 | 64403290 |
Poisoning | 15.55 | 11.17 | 3 | 73380 | 21876 | 64403473 |
Enterovirus infection | 15.43 | 11.17 | 13 | 73370 | 1444 | 64423905 |
Culture stool positive | 15.43 | 11.17 | 9 | 73374 | 554 | 64424795 |
Hypothyroidism | 15.37 | 11.17 | 14 | 73369 | 40443 | 64384906 |
Delirium | 15.37 | 11.17 | 35 | 73348 | 69159 | 64356190 |
Heart rate increased | 15.33 | 11.17 | 59 | 73324 | 98616 | 64326733 |
Withdrawal syndrome | 15.13 | 11.17 | 4 | 73379 | 23488 | 64401861 |
Vomiting | 15.11 | 11.17 | 495 | 72888 | 550622 | 63874727 |
Thrombocytopenia | 15.09 | 11.17 | 347 | 73036 | 223454 | 64201895 |
Tumour flare | 15.03 | 11.17 | 10 | 73373 | 777 | 64424572 |
Cystitis haemorrhagic | 15.00 | 11.17 | 30 | 73353 | 7926 | 64417423 |
Osteoarthritis | 14.92 | 11.17 | 31 | 73352 | 63305 | 64362044 |
Neuroleptic malignant syndrome | 14.75 | 11.17 | 5 | 73378 | 24991 | 64400358 |
Hepatitis fulminant | 14.75 | 11.17 | 26 | 73357 | 6248 | 64419101 |
Acne | 14.74 | 11.17 | 4 | 73379 | 23077 | 64402272 |
Cerebral infarction | 14.67 | 11.17 | 15 | 73368 | 41029 | 64384320 |
Melaena | 14.58 | 11.17 | 24 | 73359 | 53524 | 64371825 |
Urinary tract infection | 14.57 | 11.17 | 181 | 73202 | 231415 | 64193934 |
Neutropenia | 14.48 | 11.17 | 366 | 73017 | 239258 | 64186091 |
Surgery | 14.44 | 11.17 | 7 | 73376 | 28206 | 64397143 |
Full blood count abnormal | 14.32 | 11.17 | 8 | 73375 | 29749 | 64395600 |
Tooth disorder | 14.08 | 11.17 | 4 | 73379 | 22398 | 64402951 |
Femur fracture | 13.97 | 11.17 | 11 | 73372 | 34124 | 64391225 |
Toxic epidermal necrolysis | 13.95 | 11.17 | 81 | 73302 | 37085 | 64388264 |
Aplasia pure red cell | 13.89 | 11.17 | 27 | 73356 | 6987 | 64418362 |
Oral pain | 13.81 | 11.17 | 7 | 73376 | 27486 | 64397863 |
Heart rate decreased | 13.79 | 11.17 | 26 | 73357 | 55041 | 64370308 |
Thrombotic microangiopathy | 13.75 | 11.17 | 46 | 73337 | 16609 | 64408740 |
Heart rate irregular | 13.73 | 11.17 | 7 | 73376 | 27406 | 64397943 |
Tarsal tunnel syndrome | 13.64 | 11.17 | 8 | 73375 | 497 | 64424852 |
Granulomatous rosacea | 13.61 | 11.17 | 6 | 73377 | 203 | 64425146 |
Blood alkaline phosphatase increased | 13.57 | 11.17 | 110 | 73273 | 56169 | 64369180 |
Purpura senile | 13.56 | 11.17 | 8 | 73375 | 503 | 64424846 |
Pulmonary arterial hypertension | 13.44 | 11.17 | 6 | 73377 | 25361 | 64399988 |
Chemotherapeutic drug level increased | 13.43 | 11.17 | 7 | 73376 | 345 | 64425004 |
Hepatomegaly | 13.39 | 11.17 | 46 | 73337 | 16836 | 64408513 |
Tubulointerstitial nephritis | 13.36 | 11.17 | 70 | 73313 | 30839 | 64394510 |
Epistaxis | 13.20 | 11.17 | 62 | 73321 | 98069 | 64327280 |
Complications of transplant surgery | 13.18 | 11.17 | 9 | 73374 | 730 | 64424619 |
Oxygen saturation decreased | 13.11 | 11.17 | 70 | 73313 | 107106 | 64318243 |
Depressed level of consciousness | 13.10 | 11.17 | 48 | 73335 | 81388 | 64343961 |
HIV infection | 13.04 | 11.17 | 10 | 73373 | 972 | 64424377 |
Enterococcal infection | 13.00 | 11.17 | 40 | 73343 | 13826 | 64411523 |
Leukopenia | 12.99 | 11.17 | 174 | 73209 | 101068 | 64324281 |
Dysphagia | 12.93 | 11.17 | 70 | 73313 | 106742 | 64318607 |
Speech disorder | 12.92 | 11.17 | 22 | 73361 | 48419 | 64376930 |
Chest pain | 12.83 | 11.17 | 190 | 73193 | 235790 | 64189559 |
Wound evisceration | 12.79 | 11.17 | 5 | 73378 | 124 | 64425225 |
Vision blurred | 12.78 | 11.17 | 56 | 73327 | 90260 | 64335089 |
Injury | 12.73 | 11.17 | 108 | 73275 | 55884 | 64369465 |
Fracture | 12.46 | 11.17 | 3 | 73380 | 18752 | 64406597 |
Respiratory arrest | 12.43 | 11.17 | 26 | 73357 | 52959 | 64372390 |
Hepatosplenomegaly | 12.38 | 11.17 | 22 | 73361 | 5321 | 64420028 |
Renal failure | 12.33 | 11.17 | 282 | 73101 | 181406 | 64243943 |
Deafness transitory | 12.30 | 11.17 | 9 | 73374 | 814 | 64424535 |
Lymphocele | 12.19 | 11.17 | 12 | 73371 | 1629 | 64423720 |
Frequent bowel movements | 12.02 | 11.17 | 3 | 73380 | 18302 | 64407047 |
Mental status changes | 11.87 | 11.17 | 114 | 73269 | 61048 | 64364301 |
Lymphocytic infiltration | 11.82 | 11.17 | 11 | 73372 | 1393 | 64423956 |
Psoriatic arthropathy | 11.77 | 11.17 | 87 | 73296 | 43194 | 64382155 |
Clostridial infection | 11.76 | 11.17 | 21 | 73362 | 5098 | 64420251 |
Trimethylaminuria | 11.72 | 11.17 | 5 | 73378 | 156 | 64425193 |
Transfusion | 11.71 | 11.17 | 3 | 73380 | 17991 | 64407358 |
Bronchitis | 11.71 | 11.17 | 74 | 73309 | 108669 | 64316680 |
Rash morbilliform | 11.69 | 11.17 | 21 | 73362 | 5120 | 64420229 |
Pneumonia fungal | 11.69 | 11.17 | 29 | 73354 | 8848 | 64416501 |
Renal cyst haemorrhage | 11.65 | 11.17 | 7 | 73376 | 455 | 64424894 |
Throat irritation | 11.64 | 11.17 | 12 | 73371 | 32699 | 64392650 |
Arrhythmia | 11.58 | 11.17 | 27 | 73356 | 52917 | 64372432 |
Drug ineffective for unapproved indication | 11.56 | 11.17 | 11 | 73372 | 31122 | 64394227 |
Lung neoplasm malignant | 11.48 | 11.17 | 5 | 73378 | 21443 | 64403906 |
Electrocardiogram QT prolonged | 11.40 | 11.17 | 49 | 73334 | 79399 | 64345950 |
Pain | 11.27 | 11.17 | 752 | 72631 | 552759 | 63872590 |
Acute graft versus host disease | 11.26 | 11.17 | 29 | 73354 | 9055 | 64416294 |
Device dislocation | 11.24 | 11.17 | 5 | 73378 | 21173 | 64404176 |
Agitation | 11.21 | 11.17 | 57 | 73326 | 88310 | 64337039 |
Hepatitis C virus test | 11.17 | 11.17 | 4 | 73379 | 77 | 64425272 |
None
Source | Code | Description |
---|---|---|
ATC | J01EC01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Intermediate-acting sulfonamides |
ATC | J01EE01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives |
ATC | J04AM08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
FDA CS | M0020790 | Sulfonamides |
FDA EPC | N0000175504 | Sulfonamide Antimicrobial |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:33281 | antibiotics |
CHEBI has role | CHEBI:33282 | bactericides |
CHEBI has role | CHEBI:35441 | antiinfective agents |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50183 | P450 inhibitors |
CHEBI has role | CHEBI:50502 | dihydropteroate synthase inhibitors |
CHEBI has role | CHEBI:53000 | epitope role |
CHEBI has role | CHEBI:74234 | sepiapterin reductase inhibitors |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
FDA MoA | N0000185504 | Cytochrome P450 2C9 Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Nocardiosis | indication | 29227009 | DOID:2312 |
Shigellosis | indication | 36188001 | |
Klebsiella cystitis | indication | 60867007 | |
Toxoplasmosis | indication | 187192000 | DOID:9965 |
Chlamydial conjunctivitis | indication | 231861005 | DOID:13800 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Pneumocystosis jiroveci pneumonia | indication | 415125002 | DOID:11339 |
Acute exacerbation of chronic bronchitis | indication | 425748003 | |
Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
Haemophilus Influenzae Chronic Bronchitis | indication | ||
Aerobic Gram-Positive Cocci Infection | indication | ||
Pneumocystis Carinii Pneumonia Prevention | indication | ||
Aerobic Gram-Negative Bacillary Infection | indication | ||
Haemophilus Influenzae Acute Otitis Media | indication | ||
Morganella Morganii Urinary Tract Infection | indication | ||
Typhoid fever | off-label use | 4834000 | DOID:13258 |
Infection of skin AND/OR subcutaneous tissue | off-label use | 19824006 | |
Pertussis | off-label use | 27836007 | |
Granuloma inguinale | off-label use | 28867007 | DOID:9113 |
Listeria meningitis | off-label use | 31568009 | DOID:11572 |
Sinusitis | off-label use | 36971009 | |
Whipple's disease | off-label use | 41545003 | DOID:8476 |
Bacterial pneumonia | off-label use | 53084003 | DOID:874 |
Paracoccidioidomycosis | off-label use | 59925007 | DOID:12662 |
Cholera | off-label use | 63650001 | DOID:1498 |
Brucellosis | off-label use | 75702008 | DOID:11077 |
Paratyphoid fever | off-label use | 85904008 | DOID:3055 |
Chlamydial infection | off-label use | 105629000 | |
Infection of bone | off-label use | 111253001 | |
Meningococcus carrier | off-label use | 170486006 | |
Lymphogranuloma venereum | off-label use | 186946009 | DOID:13819 |
Chancroid | off-label use | 266143009 | DOID:13778 |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Bacterial endocarditis | off-label use | 301183007 | |
Toxoplasmosis associated with acquired immunodeficiency syndrome | off-label use | 421666009 | |
Chronic Bacterial Prostatitis | off-label use | ||
Toxoplasmosis Prevention | off-label use | ||
Postexposure Plague Prophylaxis | off-label use | ||
Diabetic Foot Infection | off-label use | ||
Glomerulonephritis | contraindication | 36171008 | DOID:2921 |
Acute hepatitis | contraindication | 37871000 | |
Third trimester pregnancy | contraindication | 41587001 | |
Uremia | contraindication | 44730006 | DOID:4676 |
Megaloblastic anemia due to folate deficiency | contraindication | 85649008 | DOID:14026 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Folic acid deficiency | contraindication | 190633005 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Porphyria | contraindication | 418470004 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.79 | acidic |
pKa2 | 2.08 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Dihydropteroate synthase | Enzyme | INHIBITOR | IC50 | 5.33 | CHEMBL | CHEMBL | |||
Bifunctional protein FolC | Enzyme | WOMBAT-PK | |||||||
Dihydrofolate reductase | Enzyme | IC50 | 7 | CHEMBL | |||||
Pol polyprotein | Enzyme | Ki | 8 | CHEMBL | |||||
Endothelin-1 receptor | GPCR | IC50 | 5.40 | CHEMBL |
ID | Source |
---|---|
4017734 | VUID |
N0000146102 | NUI |
D00447 | KEGG_DRUG |
4017734 | VANDF |
C0038689 | UMLSCUI |
CHEBI:9332 | CHEBI |
08D | PDB_CHEM_ID |
CHEMBL443 | ChEMBL_ID |
DB01015 | DRUGBANK_ID |
D013420 | MESH_DESCRIPTOR_UI |
5329 | PUBCHEM_CID |
10933 | IUPHAR_LIGAND_ID |
1386 | INN_ID |
JE42381TNV | UNII |
10180 | RXNORM |
2035 | MMSL |
5526 | MMSL |
d00119 | MMSL |
002827 | NDDF |
363528007 | SNOMEDCT_US |
70047000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0853 | SUSPENSION | 200 mg | ORAL | NDA | 28 sections |
SULFATRIM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0854 | SUSPENSION | 200 mg | ORAL | NDA | 28 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-4793 | SUSPENSION | 200 mg | ORAL | ANDA | 28 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0440-2406 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-5180 | SUSPENSION | 200 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-5181 | SUSPENSION | 200 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0615-8121 | TABLET | 800 mg | ORAL | ANDA | 26 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9503 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | ANDA | 22 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | ANDA | 22 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | ANDA | 22 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9526 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | ANDA | 22 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0904-2725 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-053 | TABLET | 800 mg | ORAL | ANDA | 26 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-092 | TABLET | 800 mg | ORAL | ANDA | 25 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-525 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-926 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-940 | TABLET | 800 mg | ORAL | ANDA | 27 sections |
Sulfamethoxazole and Trimethoprim DS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 12634-177 | TABLET | 800 mg | ORAL | ANDA | 21 sections |
SULFAMETHOXAZOLE and TRIMETHOPRIM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 12634-779 | SUSPENSION | 200 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 16590-210 | TABLET | 800 mg | ORAL | ANDA | 29 sections |
SULFATRIM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17856-0007 | SUSPENSION | 200 mg | ORAL | NDA | 21 sections |
Sulfamethoxazole and Trimethoprim | Human Prescription Drug Label | 2 | 17856-0496 | SUSPENSION | 200 mg | ORAL | ANDA | 26 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17856-0823 | SUSPENSION | 200 mg | ORAL | ANDA | 20 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17856-5181 | SUSPENSION | 200 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-125 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-701 | SUSPENSION | 200 mg | ORAL | ANDA | 20 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 33261-148 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 33261-396 | TABLET | 400 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-758 | TABLET | 400 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-759 | TABLET | 800 mg | ORAL | ANDA | 13 sections |