Stem definition | Drug id | CAS RN |
---|---|---|
anti-infectives, sulfonamides | 2514 | 723-46-6 |
Dose | Unit | Route |
---|---|---|
2 | g | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.39 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 14 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 394.82 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.36 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.23 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 9.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 30, 1973 | FDA | MONARCH PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 892.41 | 9.62 | 1992 | 122813 | 241833 | 46319424 |
Drug reaction with eosinophilia and systemic symptoms | 463.97 | 9.62 | 479 | 124326 | 29069 | 46532188 |
Pyrexia | 429.78 | 9.62 | 1956 | 122849 | 346846 | 46214411 |
Febrile neutropenia | 410.49 | 9.62 | 830 | 123975 | 93797 | 46467460 |
Neutropenia | 367.99 | 9.62 | 1024 | 123781 | 142180 | 46419077 |
Pancytopenia | 340.56 | 9.62 | 722 | 124083 | 84336 | 46476921 |
Thrombocytopenia | 339.92 | 9.62 | 920 | 123885 | 125661 | 46435596 |
Completed suicide | 273.63 | 9.62 | 34 | 124771 | 145886 | 46415371 |
Cytomegalovirus infection | 271.97 | 9.62 | 287 | 124518 | 17857 | 46543400 |
Drug ineffective | 244.48 | 9.62 | 961 | 123844 | 676877 | 45884380 |
Pneumocystis jirovecii pneumonia | 231.76 | 9.62 | 243 | 124562 | 15005 | 46546252 |
Rheumatoid arthritis | 205.00 | 9.62 | 204 | 124601 | 240011 | 46321246 |
Rash maculo-papular | 199.57 | 9.62 | 305 | 124500 | 27569 | 46533688 |
Agranulocytosis | 191.18 | 9.62 | 265 | 124540 | 21920 | 46539337 |
Stevens-Johnson syndrome | 187.02 | 9.62 | 269 | 124536 | 23028 | 46538229 |
Toxic epidermal necrolysis | 182.90 | 9.62 | 260 | 124545 | 22018 | 46539239 |
Neutrophil count decreased | 176.39 | 9.62 | 371 | 124434 | 43055 | 46518202 |
Bronchopulmonary aspergillosis | 170.04 | 9.62 | 149 | 124656 | 7347 | 46553910 |
Nocardiosis | 163.66 | 9.62 | 82 | 124723 | 1535 | 46559722 |
Fall | 159.16 | 9.62 | 408 | 124397 | 328689 | 46232568 |
Hepatocellular injury | 147.37 | 9.62 | 275 | 124530 | 29247 | 46532010 |
Febrile bone marrow aplasia | 142.96 | 9.62 | 130 | 124675 | 6732 | 46554525 |
Leukopenia | 141.34 | 9.62 | 453 | 124352 | 67890 | 46493367 |
Platelet count decreased | 134.56 | 9.62 | 577 | 124228 | 99447 | 46461810 |
Hyperkalaemia | 134.29 | 9.62 | 367 | 124438 | 50342 | 46510915 |
Acute kidney injury | 134.20 | 9.62 | 1083 | 123722 | 234772 | 46326485 |
Toxicity to various agents | 130.31 | 9.62 | 229 | 124576 | 211537 | 46349720 |
Rash | 128.69 | 9.62 | 1487 | 123318 | 355025 | 46206232 |
Drug abuse | 120.69 | 9.62 | 14 | 124791 | 63394 | 46497863 |
White blood cell count decreased | 116.23 | 9.62 | 600 | 124205 | 111631 | 46449626 |
Injection site pain | 113.83 | 9.62 | 73 | 124732 | 107079 | 46454178 |
Folliculitis | 112.86 | 9.62 | 109 | 124696 | 6094 | 46555163 |
Pain in extremity | 111.35 | 9.62 | 339 | 124466 | 258341 | 46302916 |
Muscle injury | 110.92 | 9.62 | 97 | 124708 | 4769 | 46556488 |
Pain | 108.29 | 9.62 | 789 | 124016 | 476159 | 46085098 |
Lymphopenia | 107.56 | 9.62 | 166 | 124639 | 15127 | 46546130 |
Septic shock | 107.44 | 9.62 | 370 | 124435 | 57523 | 46503734 |
Cytokine release syndrome | 101.45 | 9.62 | 103 | 124702 | 6120 | 46555137 |
Alopecia | 101.35 | 9.62 | 174 | 124631 | 162240 | 46399017 |
Immunosuppressant drug level increased | 101.22 | 9.62 | 78 | 124727 | 3204 | 46558053 |
Bone marrow failure | 99.66 | 9.62 | 235 | 124570 | 29434 | 46531823 |
Plasma cell myeloma | 99.47 | 9.62 | 303 | 124502 | 44175 | 46517082 |
Anaemia | 98.53 | 9.62 | 1081 | 123724 | 254698 | 46306559 |
Toxic skin eruption | 97.90 | 9.62 | 142 | 124663 | 12245 | 46549012 |
Sepsis | 93.87 | 9.62 | 654 | 124151 | 135360 | 46425897 |
Encephalitis viral | 91.36 | 9.62 | 56 | 124749 | 1574 | 46559683 |
Intentional overdose | 91.03 | 9.62 | 30 | 124775 | 64914 | 46496343 |
Interstitial lung disease | 90.86 | 9.62 | 334 | 124471 | 53615 | 46507642 |
Lymphocyte count decreased | 90.68 | 9.62 | 207 | 124598 | 25382 | 46535875 |
Tumour lysis syndrome | 90.30 | 9.62 | 104 | 124701 | 7132 | 46554125 |
Blood pressure increased | 88.23 | 9.62 | 126 | 124679 | 126540 | 46434717 |
Psoriasis | 85.61 | 9.62 | 52 | 124753 | 78552 | 46482705 |
Transplant rejection | 84.72 | 9.62 | 116 | 124689 | 9480 | 46551777 |
Congenital umbilical hernia | 82.14 | 9.62 | 35 | 124770 | 443 | 46560814 |
Eosinophilia | 80.12 | 9.62 | 166 | 124639 | 19051 | 46542206 |
Hepatic function abnormal | 79.32 | 9.62 | 237 | 124568 | 34184 | 46527073 |
Pre-engraftment immune reaction | 78.83 | 9.62 | 28 | 124777 | 208 | 46561049 |
Deafness transitory | 78.77 | 9.62 | 51 | 124754 | 1581 | 46559676 |
Death | 77.49 | 9.62 | 552 | 124253 | 334996 | 46226261 |
Injection site erythema | 77.27 | 9.62 | 52 | 124753 | 74375 | 46486882 |
Headache | 75.53 | 9.62 | 867 | 123938 | 477485 | 46083772 |
BK virus infection | 73.54 | 9.62 | 61 | 124744 | 2788 | 46558469 |
Polyomavirus-associated nephropathy | 72.99 | 9.62 | 47 | 124758 | 1443 | 46559814 |
Feeling abnormal | 72.61 | 9.62 | 140 | 124665 | 124920 | 46436337 |
Overdose | 71.45 | 9.62 | 101 | 124704 | 101878 | 46459379 |
Hypogammaglobulinaemia | 70.98 | 9.62 | 80 | 124725 | 5358 | 46555899 |
Myocardial infarction | 70.94 | 9.62 | 94 | 124711 | 97434 | 46463823 |
Cholestasis | 70.53 | 9.62 | 194 | 124611 | 26699 | 46534558 |
Wrong technique in product usage process | 69.77 | 9.62 | 29 | 124776 | 54393 | 46506864 |
Thrombotic microangiopathy | 69.73 | 9.62 | 98 | 124707 | 8208 | 46553049 |
Cytomegalovirus viraemia | 69.17 | 9.62 | 72 | 124733 | 4406 | 46556851 |
Sleep disorder due to general medical condition, insomnia type | 68.14 | 9.62 | 77 | 124728 | 5172 | 46556085 |
Blood creatinine increased | 67.95 | 9.62 | 392 | 124413 | 76011 | 46485246 |
Product dose omission issue | 66.75 | 9.62 | 229 | 124576 | 168291 | 46392966 |
Dizziness | 66.08 | 9.62 | 587 | 124218 | 339827 | 46221430 |
Kidney transplant rejection | 65.02 | 9.62 | 67 | 124738 | 4051 | 46557206 |
Arthralgia | 63.83 | 9.62 | 645 | 124160 | 363958 | 46197299 |
Human ehrlichiosis | 62.54 | 9.62 | 23 | 124782 | 191 | 46561066 |
Posterior reversible encephalopathy syndrome | 62.20 | 9.62 | 130 | 124675 | 15011 | 46546246 |
Suicide attempt | 61.92 | 9.62 | 35 | 124770 | 55001 | 46506256 |
Suicidal ideation | 61.81 | 9.62 | 37 | 124768 | 56345 | 46504912 |
Graft versus host disease | 61.76 | 9.62 | 82 | 124723 | 6506 | 46554751 |
Epstein-Barr virus infection | 61.39 | 9.62 | 83 | 124722 | 6701 | 46554556 |
Therapeutic product effect incomplete | 60.30 | 9.62 | 72 | 124733 | 78081 | 46483176 |
Cardiac failure congestive | 59.31 | 9.62 | 96 | 124709 | 91654 | 46469603 |
Product use in unapproved indication | 59.28 | 9.62 | 429 | 124376 | 89844 | 46471413 |
Fatigue | 59.16 | 9.62 | 1211 | 123594 | 607486 | 45953771 |
Depression | 59.01 | 9.62 | 244 | 124561 | 169860 | 46391397 |
Injection site reaction | 58.96 | 9.62 | 27 | 124778 | 47822 | 46513435 |
Pneumomediastinum | 58.54 | 9.62 | 38 | 124767 | 1183 | 46560074 |
Renal tubular acidosis | 56.35 | 9.62 | 41 | 124764 | 1542 | 46559715 |
Intentional product misuse | 55.91 | 9.62 | 28 | 124777 | 47100 | 46514157 |
Haemophagocytic lymphohistiocytosis | 55.12 | 9.62 | 88 | 124717 | 8254 | 46553003 |
Malaise | 55.07 | 9.62 | 593 | 124212 | 330639 | 46230618 |
Immune reconstitution inflammatory syndrome | 54.81 | 9.62 | 72 | 124733 | 5653 | 46555604 |
Human herpesvirus 6 infection | 54.35 | 9.62 | 48 | 124757 | 2391 | 46558866 |
Enterococcal infection | 53.62 | 9.62 | 79 | 124726 | 6908 | 46554349 |
Palpitations | 53.25 | 9.62 | 109 | 124696 | 95150 | 46466107 |
Aspergillus infection | 53.01 | 9.62 | 78 | 124727 | 6812 | 46554445 |
Acute febrile neutrophilic dermatosis | 52.31 | 9.62 | 49 | 124756 | 2636 | 46558621 |
Inappropriate schedule of product administration | 52.20 | 9.62 | 58 | 124747 | 64955 | 46496302 |
Multiple organ dysfunction syndrome | 51.77 | 9.62 | 274 | 124531 | 51436 | 46509821 |
Cytopenia | 51.40 | 9.62 | 82 | 124723 | 7686 | 46553571 |
Complications of transplanted kidney | 51.36 | 9.62 | 45 | 124760 | 2218 | 46559039 |
Injection site pruritus | 51.23 | 9.62 | 21 | 124784 | 39722 | 46521535 |
Klebsiella infection | 50.66 | 9.62 | 75 | 124730 | 6587 | 46554670 |
Infection | 50.57 | 9.62 | 563 | 124242 | 133029 | 46428228 |
Gait disturbance | 49.98 | 9.62 | 209 | 124596 | 145054 | 46416203 |
Birth mark | 49.35 | 9.62 | 20 | 124785 | 221 | 46561036 |
Pseudomonas infection | 48.80 | 9.62 | 91 | 124714 | 9667 | 46551590 |
Maternal exposure during pregnancy | 47.98 | 9.62 | 129 | 124676 | 102420 | 46458837 |
Anxiety | 47.11 | 9.62 | 289 | 124516 | 181668 | 46379589 |
Strongyloidiasis | 46.66 | 9.62 | 29 | 124776 | 836 | 46560421 |
Mobility decreased | 46.55 | 9.62 | 56 | 124749 | 60538 | 46500719 |
Injection site bruising | 45.66 | 9.62 | 19 | 124786 | 35617 | 46525640 |
Accidental exposure to product | 44.57 | 9.62 | 3 | 124802 | 21078 | 46540179 |
Injection site swelling | 43.45 | 9.62 | 27 | 124778 | 40300 | 46520957 |
Irritable bowel syndrome | 43.17 | 9.62 | 119 | 124686 | 16396 | 46544861 |
Pneumonia aspiration | 42.96 | 9.62 | 183 | 124622 | 31422 | 46529835 |
Drug eruption | 42.80 | 9.62 | 140 | 124665 | 21189 | 46540068 |
Brain abscess | 42.78 | 9.62 | 36 | 124769 | 1679 | 46559578 |
Pulmonary alveolar haemorrhage | 42.44 | 9.62 | 54 | 124751 | 4108 | 46557149 |
Hypophosphataemia | 42.35 | 9.62 | 73 | 124732 | 7294 | 46553963 |
Infective pulmonary exacerbation of cystic fibrosis | 42.32 | 9.62 | 91 | 124714 | 10716 | 46550541 |
Device expulsion | 41.73 | 9.62 | 11 | 124794 | 27531 | 46533726 |
Rhinovirus infection | 41.62 | 9.62 | 50 | 124755 | 3586 | 46557671 |
Hyperuricaemia | 41.61 | 9.62 | 57 | 124748 | 4660 | 46556597 |
Hepatitis acute | 41.58 | 9.62 | 77 | 124728 | 8137 | 46553120 |
Pemphigus | 41.41 | 9.62 | 36 | 124769 | 45238 | 46516019 |
Pneumonia | 41.21 | 9.62 | 1306 | 123499 | 375014 | 46186243 |
Product quality issue | 41.07 | 9.62 | 22 | 124783 | 35626 | 46525631 |
Tenosynovitis stenosans | 40.75 | 9.62 | 37 | 124768 | 1912 | 46559345 |
Aplasia | 40.65 | 9.62 | 49 | 124756 | 3527 | 46557730 |
Intentional self-injury | 39.91 | 9.62 | 8 | 124797 | 24158 | 46537099 |
Stomatitis | 39.45 | 9.62 | 315 | 124490 | 67982 | 46493275 |
Pneumonia bacterial | 39.33 | 9.62 | 68 | 124737 | 6811 | 46554446 |
Bacterial sepsis | 39.12 | 9.62 | 48 | 124757 | 3519 | 46557738 |
Hypofibrinogenaemia | 38.74 | 9.62 | 28 | 124777 | 1042 | 46560215 |
Synovial fluid analysis | 38.70 | 9.62 | 31 | 124774 | 1348 | 46559909 |
Balance disorder | 38.50 | 9.62 | 71 | 124734 | 64450 | 46496807 |
Haemolytic anaemia | 37.54 | 9.62 | 82 | 124723 | 9760 | 46551497 |
Aplastic anaemia | 37.40 | 9.62 | 68 | 124737 | 7085 | 46554172 |
Drug-induced liver injury | 36.92 | 9.62 | 150 | 124655 | 25218 | 46536039 |
Cerebrovascular accident | 36.87 | 9.62 | 142 | 124663 | 100897 | 46460360 |
Toxoplasmosis | 36.30 | 9.62 | 30 | 124775 | 1364 | 46559893 |
Myelosuppression | 36.25 | 9.62 | 70 | 124735 | 7633 | 46553624 |
Mucosal erosion | 36.23 | 9.62 | 30 | 124775 | 1368 | 46559889 |
Drug withdrawal syndrome | 36.06 | 9.62 | 14 | 124791 | 27370 | 46533887 |
Chronic obstructive pulmonary disease | 35.67 | 9.62 | 62 | 124743 | 57571 | 46503686 |
Osteoarthritis | 35.48 | 9.62 | 70 | 124735 | 61955 | 46499302 |
Systemic candida | 35.39 | 9.62 | 40 | 124765 | 2687 | 46558570 |
Renal impairment | 35.09 | 9.62 | 328 | 124477 | 74044 | 46487213 |
Incorrect dose administered | 35.09 | 9.62 | 42 | 124763 | 45508 | 46515749 |
Functional gastrointestinal disorder | 35.06 | 9.62 | 43 | 124762 | 3151 | 46558106 |
Hypertriglyceridaemia | 34.74 | 9.62 | 58 | 124747 | 5646 | 46555611 |
Upper respiratory tract inflammation | 34.59 | 9.62 | 40 | 124765 | 2755 | 46558502 |
Trimethylaminuria | 34.52 | 9.62 | 14 | 124791 | 155 | 46561102 |
Conjunctivitis | 34.40 | 9.62 | 105 | 124700 | 15319 | 46545938 |
Drug intolerance | 34.28 | 9.62 | 241 | 124564 | 146808 | 46414449 |
Ureaplasma infection | 34.21 | 9.62 | 19 | 124786 | 442 | 46560815 |
Memory impairment | 34.16 | 9.62 | 100 | 124705 | 77237 | 46484020 |
Glossodynia | 34.09 | 9.62 | 41 | 124764 | 44332 | 46516925 |
Blister | 33.97 | 9.62 | 220 | 124585 | 44411 | 46516846 |
Hyponatraemia | 33.86 | 9.62 | 417 | 124388 | 100915 | 46460342 |
Pseudohyponatraemia | 33.85 | 9.62 | 11 | 124794 | 60 | 46561197 |
Respiratory failure | 33.79 | 9.62 | 395 | 124410 | 94421 | 46466836 |
Pneumonia fungal | 33.32 | 9.62 | 48 | 124757 | 4112 | 46557145 |
Cushingoid | 33.31 | 9.62 | 60 | 124745 | 6206 | 46555051 |
Pneumonia cytomegaloviral | 32.97 | 9.62 | 33 | 124772 | 1927 | 46559330 |
Gastrointestinal disorder | 32.90 | 9.62 | 272 | 124533 | 59304 | 46501953 |
Blood lactate dehydrogenase increased | 32.90 | 9.62 | 125 | 124680 | 20375 | 46540882 |
Renal transplant failure | 32.81 | 9.62 | 21 | 124784 | 638 | 46560619 |
Enterocolitis | 32.71 | 9.62 | 59 | 124746 | 6109 | 46555148 |
Hypoalbuminaemia | 32.69 | 9.62 | 79 | 124726 | 10048 | 46551209 |
Graft versus host disease in gastrointestinal tract | 32.41 | 9.62 | 37 | 124768 | 2513 | 46558744 |
Pneumonia influenzal | 32.24 | 9.62 | 29 | 124776 | 1480 | 46559777 |
Breast cancer | 31.94 | 9.62 | 45 | 124760 | 45473 | 46515784 |
Osteonecrosis of jaw | 31.89 | 9.62 | 27 | 124778 | 34375 | 46526882 |
Bicytopenia | 31.71 | 9.62 | 30 | 124775 | 1634 | 46559623 |
Acute graft versus host disease | 31.55 | 9.62 | 46 | 124759 | 3984 | 46557273 |
Dysbiosis | 31.35 | 9.62 | 19 | 124786 | 523 | 46560734 |
Pneumonia streptococcal | 31.24 | 9.62 | 30 | 124775 | 1665 | 46559592 |
Acute generalised exanthematous pustulosis | 31.04 | 9.62 | 74 | 124731 | 9331 | 46551926 |
Cytomegalovirus test positive | 31.01 | 9.62 | 38 | 124767 | 2782 | 46558475 |
Cerebral toxoplasmosis | 30.95 | 9.62 | 21 | 124784 | 705 | 46560552 |
Acute respiratory distress syndrome | 30.62 | 9.62 | 128 | 124677 | 21794 | 46539463 |
Pseudoporphyria | 30.55 | 9.62 | 13 | 124792 | 164 | 46561093 |
Stress | 30.52 | 9.62 | 57 | 124748 | 51494 | 46509763 |
Alanine aminotransferase increased | 30.42 | 9.62 | 366 | 124439 | 88085 | 46473172 |
Purpura | 30.36 | 9.62 | 76 | 124729 | 9882 | 46551375 |
Obliterative bronchiolitis | 30.07 | 9.62 | 30 | 124775 | 1745 | 46559512 |
Drug dependence | 30.05 | 9.62 | 8 | 124797 | 19893 | 46541364 |
Systemic lupus erythematosus | 29.72 | 9.62 | 83 | 124722 | 65097 | 46496160 |
Knee arthroplasty | 29.70 | 9.62 | 13 | 124792 | 23652 | 46537605 |
Delayed graft function | 29.65 | 9.62 | 23 | 124782 | 954 | 46560303 |
Cholestatic liver injury | 29.44 | 9.62 | 32 | 124773 | 2058 | 46559199 |
Mixed liver injury | 29.27 | 9.62 | 39 | 124766 | 3104 | 46558153 |
Pharyngitis | 28.86 | 9.62 | 108 | 124697 | 17475 | 46543782 |
Angina pectoris | 28.74 | 9.62 | 18 | 124787 | 26757 | 46534500 |
Hyperhidrosis | 28.57 | 9.62 | 132 | 124673 | 89176 | 46472081 |
Cerebral microhaemorrhage | 28.57 | 9.62 | 11 | 124794 | 105 | 46561152 |
West Nile viral infection | 28.55 | 9.62 | 16 | 124789 | 379 | 46560878 |
Scleritis | 28.46 | 9.62 | 37 | 124768 | 2875 | 46558382 |
C-reactive protein increased | 28.44 | 9.62 | 260 | 124545 | 58330 | 46502927 |
Injection site haemorrhage | 28.26 | 9.62 | 10 | 124795 | 20699 | 46540558 |
Necrosis ischaemic | 28.08 | 9.62 | 21 | 124784 | 824 | 46560433 |
Mucosal inflammation | 27.77 | 9.62 | 189 | 124616 | 38787 | 46522470 |
Shock symptom | 27.71 | 9.62 | 9 | 124796 | 49 | 46561208 |
Coagulation test abnormal | 27.48 | 9.62 | 19 | 124786 | 658 | 46560599 |
Arthritis | 27.35 | 9.62 | 110 | 124695 | 77206 | 46484051 |
Clostridium difficile colitis | 27.23 | 9.62 | 110 | 124695 | 18443 | 46542814 |
Coronary artery disease | 27.21 | 9.62 | 30 | 124775 | 33722 | 46527535 |
Eyelid scar | 27.18 | 9.62 | 7 | 124798 | 13 | 46561244 |
Cytomegalovirus infection reactivation | 27.03 | 9.62 | 26 | 124779 | 1446 | 46559811 |
Poisoning | 26.85 | 9.62 | 3 | 124802 | 13991 | 46547266 |
Hypophagia | 26.45 | 9.62 | 151 | 124654 | 29155 | 46532102 |
Depressed mood | 26.44 | 9.62 | 30 | 124775 | 33289 | 46527968 |
Loss of consciousness | 26.40 | 9.62 | 175 | 124630 | 108063 | 46453194 |
Serotonin syndrome | 26.39 | 9.62 | 16 | 124789 | 24204 | 46537053 |
Exposure during pregnancy | 26.38 | 9.62 | 175 | 124630 | 108037 | 46453220 |
Herpes simplex oesophagitis | 26.34 | 9.62 | 11 | 124794 | 132 | 46561125 |
Injection site warmth | 26.30 | 9.62 | 3 | 124802 | 13769 | 46547488 |
Bradycardia | 26.28 | 9.62 | 90 | 124715 | 66208 | 46495049 |
Graft loss | 26.15 | 9.62 | 15 | 124790 | 372 | 46560885 |
Cardio-respiratory arrest | 26.01 | 9.62 | 78 | 124727 | 59791 | 46501466 |
Chest pain | 25.99 | 9.62 | 324 | 124481 | 176000 | 46385257 |
Pseudomembranous colitis | 25.79 | 9.62 | 37 | 124768 | 3158 | 46558099 |
Gamma-glutamyltransferase increased | 25.73 | 9.62 | 159 | 124646 | 31581 | 46529676 |
Aplasia pure red cell | 25.63 | 9.62 | 44 | 124761 | 4381 | 46556876 |
Fixed eruption | 25.46 | 9.62 | 20 | 124785 | 845 | 46560412 |
Lung transplant rejection | 25.31 | 9.62 | 19 | 124786 | 750 | 46560507 |
Bronchiectasis | 25.22 | 9.62 | 68 | 124737 | 9248 | 46552009 |
Lymph node palpable | 25.05 | 9.62 | 10 | 124795 | 106 | 46561151 |
Pathogen resistance | 24.85 | 9.62 | 52 | 124753 | 6008 | 46555249 |
Drug resistance | 24.72 | 9.62 | 102 | 124703 | 17266 | 46543991 |
Infection reactivation | 24.70 | 9.62 | 19 | 124786 | 778 | 46560479 |
Lupus enteritis | 24.65 | 9.62 | 9 | 124796 | 73 | 46561184 |
Chest discomfort | 24.59 | 9.62 | 141 | 124664 | 90128 | 46471129 |
Migraine | 24.53 | 9.62 | 100 | 124705 | 69926 | 46491331 |
Bacterial infection | 24.49 | 9.62 | 97 | 124708 | 16119 | 46545138 |
Respiratory arrest | 24.16 | 9.62 | 33 | 124772 | 33783 | 46527474 |
Mucocutaneous rash | 24.14 | 9.62 | 7 | 124798 | 24 | 46561233 |
Mycobacterium abscessus infection | 24.09 | 9.62 | 17 | 124788 | 609 | 46560648 |
Bacteraemia | 24.03 | 9.62 | 88 | 124717 | 14091 | 46547166 |
Herpes simplex | 24.02 | 9.62 | 57 | 124748 | 7166 | 46554091 |
Brain stem glioma | 23.94 | 9.62 | 9 | 124796 | 80 | 46561177 |
Dyspnoea | 23.88 | 9.62 | 1131 | 123674 | 514417 | 46046840 |
Lower respiratory tract infection | 23.55 | 9.62 | 238 | 124567 | 54851 | 46506406 |
Hypoaldosteronism | 23.28 | 9.62 | 11 | 124794 | 180 | 46561077 |
Meningitis aseptic | 23.04 | 9.62 | 40 | 124765 | 4019 | 46557238 |
Uveal prolapse | 23.00 | 9.62 | 6 | 124799 | 12 | 46561245 |
Autoimmune haemolytic anaemia | 22.93 | 9.62 | 41 | 124764 | 4217 | 46557040 |
Pleuritic pain | 22.83 | 9.62 | 52 | 124753 | 6364 | 46554893 |
Blood glucose increased | 22.70 | 9.62 | 107 | 124698 | 71906 | 46489351 |
Psoriatic arthropathy | 22.63 | 9.62 | 39 | 124766 | 36340 | 46524917 |
Acute myopia | 22.57 | 9.62 | 9 | 124796 | 95 | 46561162 |
Hypertension | 22.56 | 9.62 | 379 | 124426 | 195977 | 46365280 |
Pseudomyopia | 22.23 | 9.62 | 8 | 124797 | 62 | 46561195 |
Squamous cell carcinoma of skin | 22.09 | 9.62 | 45 | 124760 | 5102 | 46556155 |
Desmoplastic small round cell tumour | 21.95 | 9.62 | 10 | 124795 | 150 | 46561107 |
Scedosporium infection | 21.92 | 9.62 | 15 | 124790 | 511 | 46560746 |
Lymphocele | 21.75 | 9.62 | 18 | 124787 | 820 | 46560437 |
Beta haemolytic streptococcal infection | 21.66 | 9.62 | 26 | 124779 | 1863 | 46559394 |
Coma | 21.64 | 9.62 | 245 | 124560 | 58104 | 46503153 |
Rash morbilliform | 21.63 | 9.62 | 33 | 124772 | 2976 | 46558281 |
Hand deformity | 21.57 | 9.62 | 37 | 124768 | 34537 | 46526720 |
Cystitis haemorrhagic | 21.51 | 9.62 | 36 | 124769 | 3511 | 46557746 |
Antithrombin III decreased | 21.46 | 9.62 | 12 | 124793 | 283 | 46560974 |
Progressive multifocal leukoencephalopathy | 21.45 | 9.62 | 73 | 124732 | 11273 | 46549984 |
Hyperbilirubinaemia | 21.38 | 9.62 | 69 | 124736 | 10369 | 46550888 |
Eye infection toxoplasmal | 21.34 | 9.62 | 12 | 124793 | 286 | 46560971 |
Asthma | 21.33 | 9.62 | 150 | 124655 | 91392 | 46469865 |
Disseminated intravascular coagulation | 21.32 | 9.62 | 104 | 124701 | 18901 | 46542356 |
Paraesthesia | 21.19 | 9.62 | 206 | 124599 | 117231 | 46444026 |
Hip arthroplasty | 21.12 | 9.62 | 11 | 124794 | 18101 | 46543156 |
Porphyria acute | 21.09 | 9.62 | 13 | 124792 | 369 | 46560888 |
Sleep disorder | 21.03 | 9.62 | 60 | 124745 | 46735 | 46514522 |
Aspartate aminotransferase increased | 20.98 | 9.62 | 311 | 124494 | 78389 | 46482868 |
Injection site mass | 20.97 | 9.62 | 7 | 124798 | 15033 | 46546224 |
Product substitution issue | 20.95 | 9.62 | 7 | 124798 | 15024 | 46546233 |
Adverse event | 20.94 | 9.62 | 37 | 124768 | 34147 | 46527110 |
Condition aggravated | 20.93 | 9.62 | 497 | 124308 | 244555 | 46316702 |
Reticulocytopenia | 20.90 | 9.62 | 8 | 124797 | 75 | 46561182 |
Oesophageal candidiasis | 20.60 | 9.62 | 44 | 124761 | 5156 | 46556101 |
Feeding disorder | 20.53 | 9.62 | 67 | 124738 | 10127 | 46551130 |
Sopor | 20.37 | 9.62 | 14 | 124791 | 19814 | 46541443 |
Flushing | 20.37 | 9.62 | 96 | 124709 | 64518 | 46496739 |
Cytomegalovirus hepatitis | 20.34 | 9.62 | 12 | 124793 | 314 | 46560943 |
HIV infection | 20.30 | 9.62 | 15 | 124790 | 578 | 46560679 |
Renal failure | 20.26 | 9.62 | 421 | 124384 | 113173 | 46448084 |
Hyperthermia | 20.21 | 9.62 | 57 | 124748 | 7957 | 46553300 |
Crepitations | 20.17 | 9.62 | 48 | 124757 | 6044 | 46555213 |
Femur fracture | 20.10 | 9.62 | 43 | 124762 | 36954 | 46524303 |
Liver disorder | 20.00 | 9.62 | 169 | 124636 | 37077 | 46524180 |
Dermo-hypodermitis | 19.88 | 9.62 | 11 | 124794 | 254 | 46561003 |
Pancreatitis acute | 19.78 | 9.62 | 124 | 124681 | 24748 | 46536509 |
Cytokine storm | 19.72 | 9.62 | 11 | 124794 | 258 | 46560999 |
Meningoencephalitis herpetic | 19.72 | 9.62 | 19 | 124786 | 1059 | 46560198 |
Pulmonary mucormycosis | 19.69 | 9.62 | 8 | 124797 | 89 | 46561168 |
Injection site urticaria | 19.68 | 9.62 | 4 | 124801 | 11963 | 46549294 |
Vitiligo | 19.67 | 9.62 | 19 | 124786 | 1062 | 46560195 |
Acute lymphocytic leukaemia recurrent | 19.52 | 9.62 | 26 | 124779 | 2069 | 46559188 |
Chylothorax | 19.35 | 9.62 | 11 | 124794 | 268 | 46560989 |
Renal tubular necrosis | 19.28 | 9.62 | 68 | 124737 | 10691 | 46550566 |
No adverse event | 19.26 | 9.62 | 39 | 124766 | 34192 | 46527065 |
Acute myocardial infarction | 19.16 | 9.62 | 35 | 124770 | 31889 | 46529368 |
Acquired immunodeficiency syndrome | 19.08 | 9.62 | 8 | 124797 | 97 | 46561160 |
Gait inability | 19.05 | 9.62 | 41 | 124764 | 35162 | 46526095 |
Pneumocystis jirovecii infection | 19.04 | 9.62 | 20 | 124785 | 1237 | 46560020 |
Amnesia | 18.99 | 9.62 | 53 | 124752 | 41578 | 46519679 |
Pulmonary nocardiosis | 18.86 | 9.62 | 8 | 124797 | 100 | 46561157 |
Disseminated cryptococcosis | 18.85 | 9.62 | 11 | 124794 | 282 | 46560975 |
Photophobia | 18.83 | 9.62 | 83 | 124722 | 14461 | 46546796 |
Hyperammonaemia | 18.80 | 9.62 | 40 | 124765 | 4676 | 46556581 |
Nephropathy toxic | 18.78 | 9.62 | 53 | 124752 | 7401 | 46553856 |
Neck pain | 18.73 | 9.62 | 80 | 124725 | 55226 | 46506031 |
Foot deformity | 18.54 | 9.62 | 9 | 124796 | 15416 | 46545841 |
Petechiae | 18.50 | 9.62 | 75 | 124730 | 12595 | 46548662 |
Lung disorder | 18.46 | 9.62 | 187 | 124618 | 43117 | 46518140 |
Hypoaesthesia | 18.43 | 9.62 | 216 | 124589 | 118653 | 46442604 |
Renal transplant | 18.41 | 9.62 | 20 | 124785 | 1285 | 46559972 |
Product use issue | 18.38 | 9.62 | 163 | 124642 | 94481 | 46466776 |
Primary myelofibrosis | 18.35 | 9.62 | 7 | 124798 | 65 | 46561192 |
Escherichia pyelonephritis | 18.31 | 9.62 | 12 | 124793 | 380 | 46560877 |
Laryngeal stenosis | 18.28 | 9.62 | 15 | 124790 | 675 | 46560582 |
Conjunctivalisation | 18.27 | 9.62 | 5 | 124800 | 13 | 46561244 |
Cardiovascular disorder | 18.21 | 9.62 | 5 | 124800 | 12182 | 46549075 |
Hypertensive cardiomyopathy | 18.18 | 9.62 | 10 | 124795 | 228 | 46561029 |
Asteatosis | 18.16 | 9.62 | 7 | 124798 | 67 | 46561190 |
Enteritis infectious | 18.15 | 9.62 | 25 | 124780 | 2054 | 46559203 |
Post transplant lymphoproliferative disorder | 18.10 | 9.62 | 35 | 124770 | 3821 | 46557436 |
Unevaluable event | 18.08 | 9.62 | 63 | 124742 | 46112 | 46515145 |
Deafness | 18.08 | 9.62 | 88 | 124717 | 15980 | 46545277 |
Candida sepsis | 17.99 | 9.62 | 20 | 124785 | 1319 | 46559938 |
Focal myositis | 17.98 | 9.62 | 6 | 124799 | 36 | 46561221 |
Drug level increased | 17.96 | 9.62 | 97 | 124708 | 18344 | 46542913 |
Rheumatoid nodule | 17.91 | 9.62 | 59 | 124746 | 8961 | 46552296 |
Venoocclusive disease | 17.80 | 9.62 | 24 | 124781 | 1932 | 46559325 |
Treatment failure | 17.77 | 9.62 | 161 | 124644 | 92926 | 46468331 |
Cholesteatoma | 17.74 | 9.62 | 8 | 124797 | 117 | 46561140 |
Blood pressure fluctuation | 17.72 | 9.62 | 34 | 124771 | 30414 | 46530843 |
Oropharyngeal candidiasis | 17.62 | 9.62 | 17 | 124788 | 949 | 46560308 |
Chorioretinitis | 17.61 | 9.62 | 11 | 124794 | 320 | 46560937 |
Pruritus | 17.56 | 9.62 | 804 | 124001 | 241548 | 46319709 |
Liver transplant rejection | 17.46 | 9.62 | 20 | 124785 | 1363 | 46559894 |
Myalgia | 17.45 | 9.62 | 228 | 124577 | 122860 | 46438397 |
Escherichia urinary tract infection | 17.44 | 9.62 | 64 | 124741 | 10259 | 46550998 |
Device malfunction | 17.34 | 9.62 | 7 | 124798 | 13367 | 46547890 |
Varicella zoster virus infection | 17.27 | 9.62 | 26 | 124779 | 2317 | 46558940 |
Umbilical erythema | 17.22 | 9.62 | 7 | 124798 | 78 | 46561179 |
Parvovirus B19 infection | 17.19 | 9.62 | 11 | 124794 | 334 | 46560923 |
Withdrawal syndrome | 17.09 | 9.62 | 14 | 124791 | 18120 | 46543137 |
Chronic lymphocytic leukaemia | 17.01 | 9.62 | 29 | 124776 | 2871 | 46558386 |
Acinetobacter infection | 17.01 | 9.62 | 20 | 124785 | 1402 | 46559855 |
Respiratory syncytial virus infection | 17.00 | 9.62 | 39 | 124766 | 4796 | 46556461 |
Abdominal discomfort | 16.96 | 9.62 | 293 | 124512 | 150872 | 46410385 |
Rash erythematous | 16.95 | 9.62 | 153 | 124652 | 34197 | 46527060 |
Oral candidiasis | 16.93 | 9.62 | 92 | 124713 | 17440 | 46543817 |
Device dislocation | 16.90 | 9.62 | 20 | 124785 | 21782 | 46539475 |
Diffuse large B-cell lymphoma | 16.74 | 9.62 | 44 | 124761 | 5894 | 46555363 |
Rheumatoid factor positive | 16.70 | 9.62 | 18 | 124787 | 20443 | 46540814 |
Nightmare | 16.68 | 9.62 | 12 | 124793 | 16586 | 46544671 |
Escherichia infection | 16.57 | 9.62 | 65 | 124740 | 10752 | 46550505 |
Diffuse alveolar damage | 16.50 | 9.62 | 15 | 124790 | 776 | 46560481 |
Terminal ileitis | 16.50 | 9.62 | 8 | 124797 | 139 | 46561118 |
Urinary tract infection | 16.45 | 9.62 | 733 | 124072 | 219533 | 46341724 |
Mucormycosis | 16.28 | 9.62 | 25 | 124780 | 2267 | 46558990 |
Hypertensive crisis | 16.28 | 9.62 | 8 | 124797 | 13607 | 46547650 |
Immunosuppressant drug level decreased | 16.25 | 9.62 | 16 | 124789 | 916 | 46560341 |
Granulomatosis with polyangiitis | 16.23 | 9.62 | 22 | 124783 | 1780 | 46559477 |
Adenovirus infection | 16.21 | 9.62 | 28 | 124777 | 2802 | 46558455 |
Tumour flare | 16.13 | 9.62 | 10 | 124795 | 287 | 46560970 |
Hepatitis fulminant | 16.11 | 9.62 | 31 | 124774 | 3371 | 46557886 |
JC virus infection | 16.06 | 9.62 | 21 | 124784 | 1641 | 46559616 |
Gastrointestinal pain | 15.92 | 9.62 | 50 | 124755 | 7405 | 46553852 |
Fungal infection | 15.88 | 9.62 | 134 | 124671 | 29386 | 46531871 |
Pneumococcal infection | 15.86 | 9.62 | 11 | 124794 | 383 | 46560874 |
Swollen tongue | 15.86 | 9.62 | 34 | 124771 | 29198 | 46532059 |
Crying | 15.75 | 9.62 | 20 | 124785 | 21121 | 46540136 |
Exostosis | 15.74 | 9.62 | 4 | 124801 | 10259 | 46550998 |
Hepatitis | 15.65 | 9.62 | 143 | 124662 | 32072 | 46529185 |
Immunoglobulins decreased | 15.64 | 9.62 | 15 | 124790 | 831 | 46560426 |
Diabetic eye disease | 15.58 | 9.62 | 8 | 124797 | 158 | 46561099 |
Respiratory tract infection viral | 15.50 | 9.62 | 22 | 124783 | 1859 | 46559398 |
Unresponsive to stimuli | 15.40 | 9.62 | 40 | 124765 | 32134 | 46529123 |
Hot flush | 15.33 | 9.62 | 62 | 124743 | 43455 | 46517802 |
Microsporidia infection | 15.31 | 9.62 | 9 | 124796 | 234 | 46561023 |
Cardiac arrest | 15.30 | 9.62 | 161 | 124644 | 90238 | 46471019 |
Cell-mediated immune deficiency | 15.28 | 9.62 | 5 | 124800 | 28 | 46561229 |
Cytomegalovirus syndrome | 15.24 | 9.62 | 7 | 124798 | 107 | 46561150 |
Haemolysis | 15.18 | 9.62 | 43 | 124762 | 6016 | 46555241 |
Coronavirus infection | 15.17 | 9.62 | 27 | 124778 | 2767 | 46558490 |
Steroid diabetes | 15.15 | 9.62 | 13 | 124792 | 623 | 46560634 |
Cardiac disorder | 15.13 | 9.62 | 63 | 124742 | 43795 | 46517462 |
Disseminated varicella zoster vaccine virus infection | 15.08 | 9.62 | 6 | 124799 | 63 | 46561194 |
Muscle spasms | 15.00 | 9.62 | 235 | 124570 | 122878 | 46438379 |
Parainfluenzae virus infection | 14.90 | 9.62 | 21 | 124784 | 1763 | 46559494 |
Peripheral motor neuropathy | 14.81 | 9.62 | 19 | 124786 | 1457 | 46559800 |
Device issue | 14.78 | 9.62 | 19 | 124786 | 19961 | 46541296 |
Skin erosion | 14.76 | 9.62 | 24 | 124781 | 2285 | 46558972 |
Polyneuropathy | 14.74 | 9.62 | 66 | 124739 | 11578 | 46549679 |
Hyperglycaemia | 14.73 | 9.62 | 151 | 124654 | 34920 | 46526337 |
Flank pain | 14.68 | 9.62 | 67 | 124738 | 11846 | 46549411 |
Metastases to bone | 14.68 | 9.62 | 15 | 124790 | 17461 | 46543796 |
Lung neoplasm malignant | 14.55 | 9.62 | 12 | 124793 | 15477 | 46545780 |
Weight increased | 14.46 | 9.62 | 332 | 124473 | 164141 | 46397116 |
Systemic mycosis | 14.46 | 9.62 | 15 | 124790 | 914 | 46560343 |
Heart rate increased | 14.43 | 9.62 | 129 | 124676 | 74662 | 46486595 |
Systemic inflammatory response syndrome | 14.33 | 9.62 | 39 | 124766 | 5332 | 46555925 |
Graft versus host disease in skin | 14.32 | 9.62 | 24 | 124781 | 2343 | 46558914 |
Discomfort | 14.32 | 9.62 | 70 | 124735 | 46600 | 46514657 |
Septal panniculitis | 14.15 | 9.62 | 6 | 124799 | 75 | 46561182 |
Infusion related reaction | 14.15 | 9.62 | 188 | 124617 | 101020 | 46460237 |
Bandaemia | 13.98 | 9.62 | 5 | 124800 | 38 | 46561219 |
Grip strength decreased | 13.90 | 9.62 | 3 | 124802 | 8603 | 46552654 |
Excessive eye blinking | 13.84 | 9.62 | 12 | 124793 | 583 | 46560674 |
Dyskinesia | 13.81 | 9.62 | 36 | 124769 | 28889 | 46532368 |
Dermatitis exfoliative | 13.78 | 9.62 | 40 | 124765 | 5676 | 46555581 |
Clubbing | 13.76 | 9.62 | 9 | 124796 | 284 | 46560973 |
Swelling | 13.75 | 9.62 | 242 | 124563 | 124269 | 46436988 |
Pelvic venous thrombosis | 13.64 | 9.62 | 19 | 124786 | 1578 | 46559679 |
Multiple sclerosis relapse | 13.62 | 9.62 | 62 | 124743 | 42063 | 46519194 |
Medication error | 13.62 | 9.62 | 40 | 124765 | 30871 | 46530386 |
Cataract | 13.43 | 9.62 | 69 | 124736 | 45346 | 46515911 |
Hepatic necrosis | 13.31 | 9.62 | 39 | 124766 | 5562 | 46555695 |
Pain in jaw | 13.31 | 9.62 | 55 | 124750 | 38317 | 46522940 |
Chemical burn of oral cavity | 13.29 | 9.62 | 6 | 124799 | 88 | 46561169 |
Blood alkaline phosphatase increased | 13.22 | 9.62 | 163 | 124642 | 39446 | 46521811 |
Product complaint | 13.18 | 9.62 | 8 | 124797 | 12093 | 46549164 |
Culture stool positive | 13.14 | 9.62 | 9 | 124796 | 307 | 46560950 |
Candida infection | 13.06 | 9.62 | 103 | 124702 | 22137 | 46539120 |
Throat irritation | 13.03 | 9.62 | 37 | 124768 | 28864 | 46532393 |
Chronic lymphocytic leukaemia refractory | 12.96 | 9.62 | 5 | 124800 | 48 | 46561209 |
Haemolytic transfusion reaction | 12.94 | 9.62 | 4 | 124801 | 18 | 46561239 |
Therapy cessation | 12.82 | 9.62 | 33 | 124772 | 26596 | 46534661 |
Acute lymphocytic leukaemia | 12.81 | 9.62 | 25 | 124780 | 2748 | 46558509 |
Synovial cyst | 12.80 | 9.62 | 46 | 124759 | 7300 | 46553957 |
Device related bacteraemia | 12.76 | 9.62 | 4 | 124801 | 19 | 46561238 |
Transient ischaemic attack | 12.76 | 9.62 | 49 | 124756 | 34854 | 46526403 |
Opportunistic infection | 12.72 | 9.62 | 19 | 124786 | 1682 | 46559575 |
Anger | 12.68 | 9.62 | 8 | 124797 | 11844 | 46549413 |
Leukoencephalopathy | 12.67 | 9.62 | 31 | 124774 | 3973 | 46557284 |
Herpes simplex viraemia | 12.64 | 9.62 | 7 | 124798 | 162 | 46561095 |
Lipase increased | 12.62 | 9.62 | 51 | 124754 | 8552 | 46552705 |
Dermatitis bullous | 12.59 | 9.62 | 47 | 124758 | 7596 | 46553661 |
Product storage error | 12.56 | 9.62 | 8 | 124797 | 11784 | 46549473 |
Gastroenteritis | 12.53 | 9.62 | 109 | 124696 | 24110 | 46537147 |
Multiple sclerosis | 12.50 | 9.62 | 30 | 124775 | 24761 | 46536496 |
Mood swings | 12.50 | 9.62 | 15 | 124790 | 16237 | 46545020 |
Ill-defined disorder | 12.49 | 9.62 | 118 | 124687 | 26709 | 46534548 |
Road traffic accident | 12.48 | 9.62 | 28 | 124777 | 23663 | 46537594 |
Clostridium difficile infection | 12.48 | 9.62 | 112 | 124693 | 24991 | 46536266 |
Myoclonus | 12.33 | 9.62 | 73 | 124732 | 14279 | 46546978 |
Inappropriate antidiuretic hormone secretion | 12.29 | 9.62 | 72 | 124733 | 14030 | 46547227 |
Erythema multiforme | 12.28 | 9.62 | 55 | 124750 | 9649 | 46551608 |
Pneumonia pseudomonal | 12.28 | 9.62 | 21 | 124784 | 2085 | 46559172 |
Serum sickness | 12.25 | 9.62 | 23 | 124782 | 2455 | 46558802 |
Joint swelling | 12.25 | 9.62 | 344 | 124461 | 165729 | 46395528 |
Cerebral aspergillosis | 12.22 | 9.62 | 9 | 124796 | 345 | 46560912 |
Respiratory depression | 12.17 | 9.62 | 8 | 124797 | 11592 | 46549665 |
C-reactive protein abnormal | 12.16 | 9.62 | 24 | 124781 | 21246 | 46540011 |
Feeling hot | 12.16 | 9.62 | 56 | 124749 | 37872 | 46523385 |
Vomiting | 12.14 | 9.62 | 1385 | 123420 | 451409 | 46109848 |
Sedation | 12.14 | 9.62 | 27 | 124778 | 22883 | 46538374 |
Hypertransaminasaemia | 12.11 | 9.62 | 28 | 124777 | 3460 | 46557797 |
Syncope | 12.11 | 9.62 | 202 | 124603 | 104601 | 46456656 |
Anorexia nervosa | 12.08 | 9.62 | 7 | 124798 | 177 | 46561080 |
Rash papular | 11.99 | 9.62 | 67 | 124738 | 12831 | 46548426 |
Amegakaryocytic thrombocytopenia | 11.99 | 9.62 | 4 | 124801 | 24 | 46561233 |
Natural killer cell count | 11.99 | 9.62 | 4 | 124801 | 24 | 46561233 |
Stenotrophomonas infection | 11.98 | 9.62 | 18 | 124787 | 1602 | 46559655 |
Face oedema | 11.97 | 9.62 | 90 | 124715 | 19063 | 46542194 |
Human herpesvirus 6 encephalitis | 11.89 | 9.62 | 6 | 124799 | 114 | 46561143 |
Hyperamylasaemia | 11.86 | 9.62 | 9 | 124796 | 361 | 46560896 |
Lacrimation increased | 11.82 | 9.62 | 15 | 124790 | 15846 | 46545411 |
Hepatitis cholestatic | 11.79 | 9.62 | 42 | 124763 | 6635 | 46554622 |
Palmar-plantar erythrodysaesthesia syndrome | 11.76 | 9.62 | 23 | 124782 | 20428 | 46540829 |
Heart transplant rejection | 11.74 | 9.62 | 10 | 124795 | 474 | 46560783 |
Hepatic infarction | 11.72 | 9.62 | 11 | 124794 | 593 | 46560664 |
Psychotic disorder | 11.71 | 9.62 | 27 | 124778 | 22594 | 46538663 |
Influenza like illness | 11.68 | 9.62 | 98 | 124707 | 57472 | 46503785 |
Haematochezia | 11.64 | 9.62 | 56 | 124749 | 37437 | 46523820 |
Intracranial pressure increased | 11.62 | 9.62 | 31 | 124774 | 4189 | 46557068 |
Tooth abscess | 11.60 | 9.62 | 10 | 124795 | 12623 | 46548634 |
Macrophages increased | 11.59 | 9.62 | 4 | 124801 | 27 | 46561230 |
Viral haemorrhagic cystitis | 11.58 | 9.62 | 11 | 124794 | 602 | 46560655 |
Escherichia sepsis | 11.54 | 9.62 | 31 | 124774 | 4207 | 46557050 |
Pseudomonas test positive | 11.53 | 9.62 | 12 | 124793 | 734 | 46560523 |
Limb injury | 11.52 | 9.62 | 21 | 124784 | 19153 | 46542104 |
Urticaria | 11.52 | 9.62 | 404 | 124401 | 117488 | 46443769 |
Antinuclear antibody positive | 11.52 | 9.62 | 40 | 124765 | 6240 | 46555017 |
Anaphylactic shock | 11.49 | 9.62 | 23 | 124782 | 20251 | 46541006 |
Drug interaction | 11.47 | 9.62 | 658 | 124147 | 202436 | 46358821 |
Abortion spontaneous | 11.44 | 9.62 | 69 | 124736 | 43577 | 46517680 |
Spinal stenosis | 11.43 | 9.62 | 10 | 124795 | 12533 | 46548724 |
Therapeutic response decreased | 11.42 | 9.62 | 68 | 124737 | 43077 | 46518180 |
Liver transplant | 11.42 | 9.62 | 22 | 124783 | 2395 | 46558862 |
Henoch-Schonlein purpura | 11.39 | 9.62 | 14 | 124791 | 1028 | 46560229 |
Central nervous system necrosis | 11.35 | 9.62 | 6 | 124799 | 126 | 46561131 |
Fear | 11.33 | 9.62 | 16 | 124789 | 16156 | 46545101 |
Tubulointerstitial nephritis | 11.31 | 9.62 | 73 | 124732 | 14715 | 46546542 |
Investigation abnormal | 11.31 | 9.62 | 14 | 124791 | 1036 | 46560221 |
Photodermatosis | 11.30 | 9.62 | 9 | 124796 | 388 | 46560869 |
Osteoporosis | 11.28 | 9.62 | 63 | 124742 | 40545 | 46520712 |
Campylobacter gastroenteritis | 11.28 | 9.62 | 9 | 124796 | 389 | 46560868 |
Lichenification | 11.26 | 9.62 | 9 | 124796 | 390 | 46560867 |
Hip fracture | 11.24 | 9.62 | 35 | 124770 | 26521 | 46534736 |
Enterobacter infection | 11.24 | 9.62 | 19 | 124786 | 1868 | 46559389 |
Deep vein thrombosis | 11.22 | 9.62 | 286 | 124519 | 79487 | 46481770 |
Blood HIV RNULL | 11.19 | 9.62 | 3 | 124802 | 7 | 46561250 |
Hypoglycaemic seizure | 11.16 | 9.62 | 10 | 124795 | 508 | 46560749 |
Product prescribing error | 11.14 | 9.62 | 23 | 124782 | 20024 | 46541233 |
Device breakage | 11.13 | 9.62 | 6 | 124799 | 9686 | 46551571 |
Tooth disorder | 11.13 | 9.62 | 29 | 124776 | 23274 | 46537983 |
Superinfection bacterial | 11.12 | 9.62 | 9 | 124796 | 397 | 46560860 |
Limbal swelling | 11.12 | 9.62 | 4 | 124801 | 31 | 46561226 |
Post procedural bile leak | 11.10 | 9.62 | 6 | 124799 | 132 | 46561125 |
Asthenia | 11.08 | 9.62 | 700 | 124105 | 310375 | 46250882 |
Toothache | 11.06 | 9.62 | 17 | 124788 | 16575 | 46544682 |
Obesity | 11.04 | 9.62 | 13 | 124792 | 14193 | 46547064 |
Acute myeloid leukaemia recurrent | 11.02 | 9.62 | 16 | 124789 | 1380 | 46559877 |
Cachexia | 11.01 | 9.62 | 33 | 124772 | 4766 | 46556491 |
Apnoea | 10.99 | 9.62 | 3 | 124802 | 7336 | 46553921 |
Blood lactate dehydrogenase decreased | 10.97 | 9.62 | 5 | 124800 | 75 | 46561182 |
Tarsal tunnel syndrome | 10.97 | 9.62 | 11 | 124794 | 644 | 46560613 |
Transaminases increased | 10.94 | 9.62 | 118 | 124687 | 27643 | 46533614 |
Diabetic macroangiopathy | 10.94 | 9.62 | 6 | 124799 | 136 | 46561121 |
Coronary artery occlusion | 10.90 | 9.62 | 4 | 124801 | 8098 | 46553159 |
Crystalluria | 10.86 | 9.62 | 9 | 124796 | 411 | 46560846 |
Injection site induration | 10.85 | 9.62 | 4 | 124801 | 8075 | 46553182 |
Shoulder arthroplasty | 10.85 | 9.62 | 25 | 124780 | 3083 | 46558174 |
Cough | 10.83 | 9.62 | 504 | 124301 | 229745 | 46331512 |
Dyspepsia | 10.77 | 9.62 | 124 | 124681 | 68348 | 46492909 |
Dermatitis allergic | 10.76 | 9.62 | 64 | 124741 | 12539 | 46548718 |
Alanine aminotransferase abnormal | 10.73 | 9.62 | 22 | 124783 | 2505 | 46558752 |
Disability | 10.69 | 9.62 | 7 | 124798 | 10160 | 46551097 |
Cheilitis | 10.68 | 9.62 | 29 | 124776 | 3959 | 46557298 |
Rash macular | 10.66 | 9.62 | 88 | 124717 | 19172 | 46542085 |
CD4 lymphocytes decreased | 10.66 | 9.62 | 17 | 124788 | 1593 | 46559664 |
Neonatal pneumonia | 10.65 | 9.62 | 3 | 124802 | 9 | 46561248 |
Ear infection | 10.60 | 9.62 | 101 | 124704 | 22912 | 46538345 |
Rhabdomyolysis | 10.60 | 9.62 | 67 | 124738 | 41842 | 46519415 |
Band sensation | 10.59 | 9.62 | 11 | 124794 | 671 | 46560586 |
AIDS related complication | 10.59 | 9.62 | 4 | 124801 | 36 | 46561221 |
Arthropathy | 10.54 | 9.62 | 161 | 124644 | 84539 | 46476718 |
Death neonatal | 10.53 | 9.62 | 7 | 124798 | 227 | 46561030 |
Device related infection | 10.53 | 9.62 | 94 | 124711 | 20947 | 46540310 |
Escherichia bacteraemia | 10.52 | 9.62 | 23 | 124782 | 2738 | 46558519 |
Cytomegalovirus enterocolitis | 10.52 | 9.62 | 10 | 124795 | 548 | 46560709 |
Hyperferritinaemia | 10.46 | 9.62 | 5 | 124800 | 84 | 46561173 |
Genital erosion | 10.42 | 9.62 | 6 | 124799 | 150 | 46561107 |
Prothrombin level abnormal | 10.41 | 9.62 | 5 | 124800 | 85 | 46561172 |
SJS-TEN overlap | 10.38 | 9.62 | 6 | 124799 | 151 | 46561106 |
Leukaemia recurrent | 10.33 | 9.62 | 15 | 124790 | 1294 | 46559963 |
Intracranial tumour haemorrhage | 10.31 | 9.62 | 6 | 124799 | 153 | 46561104 |
Fluid retention | 10.31 | 9.62 | 87 | 124718 | 50959 | 46510298 |
Renal lymphocele | 10.31 | 9.62 | 5 | 124800 | 87 | 46561170 |
Dermatomyositis | 10.30 | 9.62 | 19 | 124786 | 2002 | 46559255 |
Mitral valve disease | 10.29 | 9.62 | 20 | 124785 | 2192 | 46559065 |
Respiratory disorder | 10.28 | 9.62 | 115 | 124690 | 27185 | 46534072 |
Blood loss anaemia | 10.27 | 9.62 | 5 | 124800 | 8552 | 46552705 |
Hepatosplenomegaly | 10.26 | 9.62 | 21 | 124784 | 2389 | 46558868 |
Extrapyramidal disorder | 10.25 | 9.62 | 9 | 124796 | 11259 | 46549998 |
Gynaecological chlamydia infection | 10.22 | 9.62 | 4 | 124801 | 40 | 46561217 |
Cryptococcosis | 10.22 | 9.62 | 12 | 124793 | 840 | 46560417 |
Epstein-Barr virus test positive | 10.19 | 9.62 | 10 | 124795 | 570 | 46560687 |
Staphylococcal infection | 10.18 | 9.62 | 143 | 124662 | 35628 | 46525629 |
Mitral valve incompetence | 10.17 | 9.62 | 22 | 124783 | 18830 | 46542427 |
Speech disorder | 10.11 | 9.62 | 56 | 124749 | 36111 | 46525146 |
Delusion | 10.10 | 9.62 | 9 | 124796 | 11179 | 46550078 |
Mucocutaneous ulceration | 10.07 | 9.62 | 6 | 124799 | 160 | 46561097 |
Enterococcal sepsis | 10.06 | 9.62 | 15 | 124790 | 1325 | 46559932 |
Thrombotic thrombocytopenic purpura | 10.04 | 9.62 | 28 | 124777 | 3882 | 46557375 |
Megacolon | 10.04 | 9.62 | 17 | 124788 | 1674 | 46559583 |
Injection site discolouration | 10.02 | 9.62 | 3 | 124802 | 6907 | 46554350 |
Gastrointestinal haemorrhage | 10.00 | 9.62 | 146 | 124659 | 77227 | 46484030 |
Chronic hepatitis B | 9.99 | 9.62 | 7 | 124798 | 248 | 46561009 |
Lymphadenitis viral | 9.99 | 9.62 | 3 | 124802 | 12 | 46561245 |
Myeloid maturation arrest | 9.99 | 9.62 | 3 | 124802 | 12 | 46561245 |
Vaginal haemorrhage | 9.98 | 9.62 | 35 | 124770 | 25569 | 46535688 |
Disseminated mycobacterium avium complex infection | 9.97 | 9.62 | 4 | 124801 | 43 | 46561214 |
Renal tubular disorder | 9.93 | 9.62 | 21 | 124784 | 2444 | 46558813 |
Central nervous system fungal infection | 9.91 | 9.62 | 5 | 124800 | 95 | 46561162 |
Immune thrombocytopenia | 9.90 | 9.62 | 46 | 124759 | 8195 | 46553062 |
Nephrolithiasis | 9.89 | 9.62 | 50 | 124755 | 33001 | 46528256 |
Fungal endocarditis | 9.89 | 9.62 | 7 | 124798 | 252 | 46561005 |
Emotional disorder | 9.88 | 9.62 | 11 | 124794 | 12313 | 46548944 |
Starvation | 9.84 | 9.62 | 6 | 124799 | 167 | 46561090 |
Osteopenia | 9.82 | 9.62 | 19 | 124786 | 16942 | 46544315 |
Panic attack | 9.81 | 9.62 | 25 | 124780 | 20217 | 46541040 |
Blastomycosis | 9.79 | 9.62 | 7 | 124798 | 256 | 46561001 |
Musculoskeletal discomfort | 9.76 | 9.62 | 14 | 124791 | 14042 | 46547215 |
Labelled drug-drug interaction medication error | 9.75 | 9.62 | 49 | 124756 | 9012 | 46552245 |
Pityriasis lichenoides et varioliformis acuta | 9.73 | 9.62 | 4 | 124801 | 46 | 46561211 |
Cerebral fungal infection | 9.73 | 9.62 | 4 | 124801 | 46 | 46561211 |
Abdominal wall infection | 9.73 | 9.62 | 5 | 124800 | 99 | 46561158 |
Irritability | 9.72 | 9.62 | 42 | 124763 | 28904 | 46532353 |
Epstein-Barr virus infection reactivation | 9.72 | 9.62 | 7 | 124798 | 259 | 46560998 |
Enterovirus infection | 9.71 | 9.62 | 10 | 124795 | 604 | 46560653 |
Serositis | 9.71 | 9.62 | 10 | 124795 | 604 | 46560653 |
Illness | 9.70 | 9.62 | 11 | 124794 | 12213 | 46549044 |
Prinzmetal angina | 9.67 | 9.62 | 11 | 124794 | 744 | 46560513 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pyrexia | 539.97 | 10.09 | 2601 | 126626 | 291888 | 29531363 |
Drug reaction with eosinophilia and systemic symptoms | 438.98 | 10.09 | 577 | 128650 | 27911 | 29795340 |
Febrile neutropenia | 426.79 | 10.09 | 1215 | 128012 | 105478 | 29717773 |
Completed suicide | 325.44 | 10.09 | 28 | 129199 | 99464 | 29723787 |
Pancytopenia | 322.90 | 10.09 | 951 | 128276 | 84101 | 29739150 |
Cytomegalovirus infection | 322.89 | 10.09 | 452 | 128775 | 23222 | 29800029 |
Pneumocystis jirovecii pneumonia | 311.74 | 10.09 | 377 | 128850 | 16743 | 29806508 |
Drug abuse | 295.31 | 10.09 | 14 | 129213 | 82058 | 29741193 |
Hyperkalaemia | 292.63 | 10.09 | 781 | 128446 | 65229 | 29758022 |
Neutropenia | 287.91 | 10.09 | 1207 | 128020 | 127333 | 29695918 |
Death | 235.16 | 10.09 | 776 | 128451 | 356507 | 29466744 |
Immune reconstitution inflammatory syndrome | 230.28 | 10.09 | 238 | 128989 | 8863 | 29814388 |
Thrombocytopenia | 221.78 | 10.09 | 1171 | 128056 | 135873 | 29687378 |
Toxicity to various agents | 215.44 | 10.09 | 269 | 128958 | 176914 | 29646337 |
Rash maculo-papular | 210.97 | 10.09 | 387 | 128840 | 25031 | 29798220 |
Acute kidney injury | 208.85 | 10.09 | 1946 | 127281 | 271896 | 29551355 |
Cytomegalovirus viraemia | 206.18 | 10.09 | 182 | 129045 | 5547 | 29817704 |
Agranulocytosis | 202.57 | 10.09 | 350 | 128877 | 21592 | 29801659 |
Nocardiosis | 193.04 | 10.09 | 142 | 129085 | 3313 | 29819938 |
Stevens-Johnson syndrome | 164.61 | 10.09 | 282 | 128945 | 17274 | 29805977 |
Transplant rejection | 163.12 | 10.09 | 200 | 129027 | 9006 | 29814245 |
Cytokine release syndrome | 152.59 | 10.09 | 201 | 129026 | 9732 | 29813519 |
Neutrophil count decreased | 150.76 | 10.09 | 464 | 128763 | 41990 | 29781261 |
Myocardial infarction | 150.18 | 10.09 | 193 | 129034 | 125432 | 29697819 |
Leukopenia | 147.67 | 10.09 | 555 | 128672 | 55604 | 29767647 |
Dizziness | 135.68 | 10.09 | 412 | 128815 | 194497 | 29628754 |
Intentional overdose | 131.98 | 10.09 | 13 | 129214 | 41468 | 29781783 |
Hepatocellular injury | 128.89 | 10.09 | 317 | 128910 | 25154 | 29798097 |
Drug ineffective | 119.49 | 10.09 | 920 | 128307 | 339467 | 29483784 |
Aspergillus infection | 116.04 | 10.09 | 179 | 129048 | 10035 | 29813216 |
Platelet count decreased | 115.03 | 10.09 | 818 | 128409 | 105311 | 29717940 |
Lymphocyte count decreased | 113.72 | 10.09 | 253 | 128974 | 18802 | 29804449 |
Febrile bone marrow aplasia | 110.94 | 10.09 | 155 | 129072 | 7942 | 29815309 |
Fall | 109.74 | 10.09 | 409 | 128818 | 181463 | 29641788 |
Bronchopulmonary aspergillosis | 109.51 | 10.09 | 193 | 129034 | 12091 | 29811160 |
Cholestasis | 108.17 | 10.09 | 293 | 128934 | 24657 | 29798594 |
Suicide attempt | 99.12 | 10.09 | 19 | 129208 | 36678 | 29786573 |
Cerebrovascular accident | 96.87 | 10.09 | 131 | 129096 | 83346 | 29739905 |
Rash | 96.12 | 10.09 | 1256 | 127971 | 190633 | 29632618 |
Lymphopenia | 95.11 | 10.09 | 189 | 129038 | 12974 | 29810277 |
Anxiety | 92.68 | 10.09 | 153 | 129074 | 89718 | 29733533 |
Thrombotic microangiopathy | 92.40 | 10.09 | 147 | 129080 | 8463 | 29814788 |
Pain | 89.31 | 10.09 | 412 | 128815 | 172229 | 29651022 |
Rheumatoid arthritis | 89.26 | 10.09 | 33 | 129194 | 41164 | 29782087 |
Kidney transplant rejection | 87.27 | 10.09 | 133 | 129094 | 7376 | 29815875 |
Fatigue | 85.73 | 10.09 | 928 | 128299 | 319745 | 29503506 |
Septic shock | 84.47 | 10.09 | 516 | 128711 | 63091 | 29760160 |
Product use in unapproved indication | 83.29 | 10.09 | 574 | 128653 | 73119 | 29750132 |
Cardiac failure congestive | 83.09 | 10.09 | 148 | 129079 | 84259 | 29738992 |
Depression | 81.66 | 10.09 | 167 | 129060 | 90270 | 29732981 |
White blood cell count decreased | 79.55 | 10.09 | 627 | 128600 | 83320 | 29739931 |
Toxic skin eruption | 79.39 | 10.09 | 158 | 129069 | 10857 | 29812394 |
Product dose omission issue | 77.91 | 10.09 | 175 | 129052 | 91456 | 29731795 |
Haemophagocytic lymphohistiocytosis | 77.35 | 10.09 | 146 | 129081 | 9645 | 29813606 |
Aplasia | 76.90 | 10.09 | 91 | 129136 | 3946 | 29819305 |
Sepsis | 75.64 | 10.09 | 964 | 128263 | 145431 | 29677820 |
Acute febrile neutrophilic dermatosis | 75.31 | 10.09 | 52 | 129175 | 1094 | 29822157 |
Overdose | 75.07 | 10.09 | 157 | 129070 | 84180 | 29739071 |
Bone marrow failure | 73.83 | 10.09 | 289 | 128938 | 29496 | 29793755 |
Graft versus host disease | 73.64 | 10.09 | 146 | 129081 | 10004 | 29813247 |
Arthralgia | 73.22 | 10.09 | 319 | 128908 | 135472 | 29687779 |
Blood creatinine increased | 73.06 | 10.09 | 657 | 128570 | 90718 | 29732533 |
Dermatitis exfoliative generalised | 70.09 | 10.09 | 73 | 129154 | 2742 | 29820509 |
Coronary artery disease | 69.61 | 10.09 | 67 | 129160 | 49645 | 29773606 |
Pseudomonas infection | 69.20 | 10.09 | 145 | 129082 | 10337 | 29812914 |
Acute myocardial infarction | 68.86 | 10.09 | 76 | 129151 | 52863 | 29770388 |
Loss of consciousness | 68.77 | 10.09 | 150 | 129077 | 79225 | 29744026 |
Chronic lymphocytic leukaemia | 68.54 | 10.09 | 92 | 129135 | 4536 | 29818715 |
Epstein-Barr virus infection | 67.21 | 10.09 | 111 | 129116 | 6595 | 29816656 |
Aggression | 66.84 | 10.09 | 38 | 129189 | 36869 | 29786382 |
Congenital umbilical hernia | 66.50 | 10.09 | 33 | 129194 | 362 | 29822889 |
Toxic epidermal necrolysis | 65.43 | 10.09 | 198 | 129029 | 17742 | 29805509 |
Hepatitis | 64.67 | 10.09 | 228 | 128999 | 22128 | 29801123 |
Injection site pain | 64.45 | 10.09 | 25 | 129202 | 30285 | 29792966 |
Pain in extremity | 62.44 | 10.09 | 254 | 128973 | 109967 | 29713284 |
Blood pressure increased | 62.25 | 10.09 | 136 | 129091 | 71792 | 29751459 |
Blood lactate dehydrogenase increased | 62.10 | 10.09 | 213 | 129014 | 20388 | 29802863 |
Therapeutic product effect decreased | 61.79 | 10.09 | 24 | 129203 | 29052 | 29794199 |
Somnolence | 61.30 | 10.09 | 213 | 129014 | 96550 | 29726701 |
Pneumonia | 61.04 | 10.09 | 1879 | 127348 | 332427 | 29490824 |
Rash morbilliform | 60.72 | 10.09 | 64 | 129163 | 2438 | 29820813 |
Feeling abnormal | 60.01 | 10.09 | 95 | 129132 | 56661 | 29766590 |
Pathogen resistance | 59.85 | 10.09 | 120 | 129107 | 8290 | 29814961 |
Syncope | 58.55 | 10.09 | 180 | 129047 | 84723 | 29738528 |
Pneumonia cytomegaloviral | 58.24 | 10.09 | 66 | 129161 | 2730 | 29820521 |
Anaemia | 58.20 | 10.09 | 1238 | 127989 | 206754 | 29616497 |
Chest pain | 57.09 | 10.09 | 287 | 128940 | 117340 | 29705911 |
Hypofibrinogenaemia | 56.68 | 10.09 | 51 | 129176 | 1594 | 29821657 |
Dyspnoea | 56.51 | 10.09 | 1056 | 128171 | 332239 | 29491012 |
Candida infection | 56.45 | 10.09 | 170 | 129057 | 15192 | 29808059 |
Inappropriate schedule of product administration | 56.25 | 10.09 | 53 | 129174 | 39675 | 29783576 |
Polyomavirus-associated nephropathy | 56.10 | 10.09 | 69 | 129158 | 3116 | 29820135 |
Eosinophilia | 55.71 | 10.09 | 216 | 129011 | 21944 | 29801307 |
Psoriasis | 55.30 | 10.09 | 61 | 129166 | 42445 | 29780806 |
Dermatitis exfoliative | 55.00 | 10.09 | 108 | 129119 | 7348 | 29815903 |
Cryptococcosis | 54.60 | 10.09 | 52 | 129175 | 1750 | 29821501 |
BK virus infection | 54.58 | 10.09 | 80 | 129147 | 4284 | 29818967 |
Squamous cell carcinoma of skin | 53.40 | 10.09 | 120 | 129107 | 8975 | 29814276 |
Malaise | 53.40 | 10.09 | 462 | 128765 | 166500 | 29656751 |
Drug hypersensitivity | 52.87 | 10.09 | 489 | 128738 | 68030 | 29755221 |
Human herpesvirus 6 infection | 52.79 | 10.09 | 53 | 129174 | 1905 | 29821346 |
Renal tubular necrosis | 51.61 | 10.09 | 164 | 129063 | 15087 | 29808164 |
Suicidal ideation | 51.34 | 10.09 | 48 | 129179 | 36066 | 29787185 |
Acute generalised exanthematous pustulosis | 50.76 | 10.09 | 93 | 129134 | 6005 | 29817246 |
Cardiac arrest | 50.69 | 10.09 | 217 | 129010 | 92633 | 29730618 |
Infection reactivation | 50.66 | 10.09 | 38 | 129189 | 914 | 29822337 |
Tumour lysis syndrome | 50.60 | 10.09 | 146 | 129081 | 12739 | 29810512 |
Plasma cell myeloma | 50.43 | 10.09 | 399 | 128828 | 53063 | 29770188 |
Joint swelling | 50.17 | 10.09 | 78 | 129149 | 46868 | 29776383 |
Toxoplasmosis | 49.73 | 10.09 | 39 | 129188 | 1004 | 29822247 |
Neuroleptic malignant syndrome | 49.55 | 10.09 | 6 | 129221 | 16289 | 29806962 |
Renal tubular acidosis | 48.53 | 10.09 | 49 | 129178 | 1773 | 29821478 |
Delayed graft function | 48.36 | 10.09 | 48 | 129179 | 1701 | 29821550 |
Pneumonia fungal | 48.11 | 10.09 | 86 | 129141 | 5447 | 29817804 |
Sedation | 47.47 | 10.09 | 7 | 129220 | 16366 | 29806885 |
Cardio-respiratory arrest | 47.42 | 10.09 | 111 | 129116 | 57195 | 29766056 |
Wrong technique in product usage process | 47.19 | 10.09 | 39 | 129188 | 31116 | 29792135 |
Encephalitis viral | 46.97 | 10.09 | 40 | 129187 | 1160 | 29822091 |
Bradycardia | 46.54 | 10.09 | 137 | 129090 | 65389 | 29757862 |
Cystitis haemorrhagic | 46.32 | 10.09 | 78 | 129149 | 4709 | 29818542 |
Gait disturbance | 45.75 | 10.09 | 167 | 129060 | 74610 | 29748641 |
Vanishing bile duct syndrome | 45.53 | 10.09 | 31 | 129196 | 637 | 29822614 |
Strongyloidiasis | 44.88 | 10.09 | 53 | 129174 | 2293 | 29820958 |
Immunosuppressant drug level increased | 44.68 | 10.09 | 76 | 129151 | 4626 | 29818625 |
Drug dependence | 44.56 | 10.09 | 18 | 129209 | 21277 | 29801974 |
Product quality issue | 44.23 | 10.09 | 13 | 129214 | 18761 | 29804490 |
Complications of transplanted kidney | 43.98 | 10.09 | 70 | 129157 | 4031 | 29819220 |
Transaminases increased | 43.82 | 10.09 | 209 | 129018 | 23248 | 29800003 |
Pulmonary nocardiosis | 43.62 | 10.09 | 25 | 129202 | 374 | 29822877 |
Enterococcal infection | 43.34 | 10.09 | 104 | 129123 | 8120 | 29815131 |
Adenovirus infection | 43.24 | 10.09 | 71 | 129156 | 4197 | 29819054 |
Cytomegalovirus test positive | 42.98 | 10.09 | 65 | 129162 | 3580 | 29819671 |
Agitation | 42.95 | 10.09 | 107 | 129120 | 53966 | 29769285 |
Hyperhidrosis | 42.93 | 10.09 | 147 | 129080 | 66943 | 29756308 |
Chest discomfort | 42.72 | 10.09 | 82 | 129145 | 45398 | 29777853 |
Drug withdrawal syndrome | 42.68 | 10.09 | 16 | 129211 | 19793 | 29803458 |
Intentional product misuse | 42.67 | 10.09 | 52 | 129175 | 34615 | 29788636 |
Rhinovirus infection | 42.03 | 10.09 | 57 | 129170 | 2838 | 29820413 |
Mycobacterium avium complex infection | 41.85 | 10.09 | 55 | 129172 | 2656 | 29820595 |
Injury | 41.36 | 10.09 | 21 | 129206 | 21710 | 29801541 |
Insomnia | 41.23 | 10.09 | 235 | 128992 | 93101 | 29730150 |
Microsporidia infection | 41.09 | 10.09 | 28 | 129199 | 576 | 29822675 |
Hepatitis cholestatic | 40.89 | 10.09 | 99 | 129128 | 7773 | 29815478 |
Musculoskeletal stiffness | 40.89 | 10.09 | 57 | 129170 | 35824 | 29787427 |
Multiple organ dysfunction syndrome | 40.68 | 10.09 | 436 | 128791 | 63051 | 29760200 |
Aplastic anaemia | 40.40 | 10.09 | 80 | 129147 | 5476 | 29817775 |
Alanine aminotransferase increased | 40.37 | 10.09 | 494 | 128733 | 73782 | 29749469 |
Weight increased | 40.32 | 10.09 | 176 | 129051 | 74737 | 29748514 |
Back pain | 40.28 | 10.09 | 268 | 128959 | 102328 | 29720923 |
Hypogammaglobulinaemia | 39.86 | 10.09 | 77 | 129150 | 5175 | 29818076 |
Stress | 39.35 | 10.09 | 19 | 129208 | 20216 | 29803035 |
Liver transplant rejection | 39.33 | 10.09 | 48 | 129179 | 2150 | 29821101 |
Chronic obstructive pulmonary disease | 39.25 | 10.09 | 88 | 129139 | 46038 | 29777213 |
Hepatic function abnormal | 38.98 | 10.09 | 312 | 128915 | 41633 | 29781618 |
Mucormycosis | 38.48 | 10.09 | 76 | 129151 | 5192 | 29818059 |
Face oedema | 38.46 | 10.09 | 122 | 129105 | 11212 | 29812039 |
Pneumonia bacterial | 38.33 | 10.09 | 108 | 129119 | 9295 | 29813956 |
Tubulointerstitial nephritis | 38.33 | 10.09 | 166 | 129061 | 17725 | 29805526 |
Transplant dysfunction | 38.31 | 10.09 | 49 | 129178 | 2303 | 29820948 |
Respiratory arrest | 38.04 | 10.09 | 42 | 129185 | 29216 | 29794035 |
Dysplastic naevus | 37.87 | 10.09 | 22 | 129205 | 338 | 29822913 |
Lymphadenopathy | 37.03 | 10.09 | 205 | 129022 | 24171 | 29799080 |
Respiratory failure | 36.99 | 10.09 | 625 | 128602 | 100017 | 29723234 |
Device related infection | 36.55 | 10.09 | 158 | 129069 | 16857 | 29806394 |
Photodermatosis | 36.52 | 10.09 | 23 | 129204 | 412 | 29822839 |
Autoimmune haemolytic anaemia | 36.46 | 10.09 | 64 | 129163 | 3995 | 29819256 |
Trichophytosis | 35.68 | 10.09 | 20 | 129207 | 286 | 29822965 |
Parainfluenzae virus infection | 35.65 | 10.09 | 44 | 129183 | 1994 | 29821257 |
Blood urea increased | 34.57 | 10.09 | 243 | 128984 | 31138 | 29792113 |
Gamma-glutamyltransferase increased | 34.54 | 10.09 | 231 | 128996 | 29119 | 29794132 |
Headache | 34.49 | 10.09 | 566 | 128661 | 181740 | 29641511 |
Contusion | 34.35 | 10.09 | 51 | 129176 | 31229 | 29792022 |
Solar lentigo | 33.72 | 10.09 | 20 | 129207 | 320 | 29822931 |
Sopor | 33.54 | 10.09 | 4 | 129223 | 10987 | 29812264 |
Mucosal inflammation | 33.51 | 10.09 | 236 | 128991 | 30258 | 29792993 |
Gastrointestinal haemorrhage | 33.24 | 10.09 | 217 | 129010 | 83229 | 29740022 |
Hypoalbuminaemia | 32.83 | 10.09 | 114 | 129113 | 10978 | 29812273 |
Cardiac disorder | 32.42 | 10.09 | 78 | 129149 | 39815 | 29783436 |
Haemolytic anaemia | 32.38 | 10.09 | 106 | 129121 | 9904 | 29813347 |
Haematochezia | 31.88 | 10.09 | 62 | 129165 | 34160 | 29789091 |
Asthenia | 31.78 | 10.09 | 720 | 128507 | 220570 | 29602681 |
Hallucination | 31.71 | 10.09 | 107 | 129120 | 48952 | 29774299 |
Jarisch-Herxheimer reaction | 31.64 | 10.09 | 21 | 129206 | 413 | 29822838 |
Blood creatine phosphokinase increased | 31.62 | 10.09 | 91 | 129136 | 43757 | 29779494 |
Asthma | 31.61 | 10.09 | 68 | 129159 | 36106 | 29787145 |
Paracoccidioides infection | 31.58 | 10.09 | 13 | 129214 | 88 | 29823163 |
Lymphocele | 31.33 | 10.09 | 35 | 129192 | 1425 | 29821826 |
Actinic keratosis | 31.32 | 10.09 | 56 | 129171 | 3547 | 29819704 |
Post transplant lymphoproliferative disorder | 31.14 | 10.09 | 70 | 129157 | 5236 | 29818015 |
Pneumonia pseudomonal | 31.00 | 10.09 | 55 | 129172 | 3463 | 29819788 |
Sleep disorder | 30.89 | 10.09 | 36 | 129191 | 24443 | 29798808 |
Medication error | 30.85 | 10.09 | 27 | 129200 | 20945 | 29802306 |
Muscle rigidity | 30.66 | 10.09 | 4 | 129223 | 10257 | 29812994 |
Hypertriglyceridaemia | 30.11 | 10.09 | 90 | 129137 | 8008 | 29815243 |
Reticulocytosis | 29.97 | 10.09 | 18 | 129209 | 295 | 29822956 |
Memory impairment | 29.95 | 10.09 | 73 | 129154 | 37101 | 29786150 |
Erectile dysfunction | 29.53 | 10.09 | 21 | 129206 | 18081 | 29805170 |
Palpitations | 29.42 | 10.09 | 63 | 129164 | 33510 | 29789741 |
Birth mark | 29.28 | 10.09 | 16 | 129211 | 217 | 29823034 |
Hyperferritinaemia | 29.24 | 10.09 | 19 | 129208 | 360 | 29822891 |
Rhabdomyolysis | 29.20 | 10.09 | 158 | 129069 | 63422 | 29759829 |
Microangiopathic haemolytic anaemia | 29.15 | 10.09 | 26 | 129201 | 803 | 29822448 |
Drug-induced liver injury | 29.10 | 10.09 | 174 | 129053 | 21100 | 29802151 |
Fusarium infection | 29.05 | 10.09 | 29 | 129198 | 1035 | 29822216 |
Immune effector cell-associated neurotoxicity syndrome | 28.44 | 10.09 | 26 | 129201 | 830 | 29822421 |
Therapeutic product effect incomplete | 28.41 | 10.09 | 65 | 129162 | 33769 | 29789482 |
Fear | 28.40 | 10.09 | 6 | 129221 | 10819 | 29812432 |
Infection | 28.36 | 10.09 | 484 | 128743 | 77590 | 29745661 |
Hyperuricaemia | 28.28 | 10.09 | 83 | 129144 | 7311 | 29815940 |
Neuropathy peripheral | 28.24 | 10.09 | 444 | 128783 | 70031 | 29753220 |
Fungal skin infection | 28.15 | 10.09 | 43 | 129184 | 2389 | 29820862 |
Cytomegalovirus enteritis | 28.13 | 10.09 | 19 | 129208 | 385 | 29822866 |
Hypotension | 28.10 | 10.09 | 655 | 128572 | 199910 | 29623341 |
Extrapyramidal disorder | 27.90 | 10.09 | 6 | 129221 | 10687 | 29812564 |
Blood glucose increased | 27.66 | 10.09 | 154 | 129073 | 61376 | 29761875 |
Liver disorder | 27.56 | 10.09 | 221 | 129006 | 29501 | 29793750 |
Cytomegalovirus colitis | 27.45 | 10.09 | 42 | 129185 | 2337 | 29820914 |
Unresponsive to stimuli | 27.18 | 10.09 | 45 | 129182 | 26374 | 29796877 |
Aspartate aminotransferase increased | 27.11 | 10.09 | 404 | 128823 | 63018 | 29760233 |
Oral candidiasis | 27.08 | 10.09 | 107 | 129120 | 10964 | 29812287 |
Depressed level of consciousness | 27.07 | 10.09 | 80 | 129147 | 38142 | 29785109 |
Klebsiella infection | 27.00 | 10.09 | 78 | 129149 | 6809 | 29816442 |
Progressive multifocal leukoencephalopathy | 26.99 | 10.09 | 93 | 129134 | 8920 | 29814331 |
Hyperleukocytosis | 26.96 | 10.09 | 34 | 129193 | 1575 | 29821676 |
Hepatomegaly | 26.95 | 10.09 | 100 | 129127 | 9947 | 29813304 |
Crystalluria | 26.64 | 10.09 | 18 | 129209 | 365 | 29822886 |
Disseminated cryptococcosis | 26.63 | 10.09 | 27 | 129200 | 982 | 29822269 |
Abdominal discomfort | 26.62 | 10.09 | 114 | 129113 | 48677 | 29774574 |
Poisoning | 26.60 | 10.09 | 8 | 129219 | 11374 | 29811877 |
Epidermal necrosis | 26.40 | 10.09 | 19 | 129208 | 428 | 29822823 |
Blood immunoglobulin G decreased | 26.37 | 10.09 | 26 | 129201 | 914 | 29822337 |
Pyelonephritis | 25.83 | 10.09 | 66 | 129161 | 5360 | 29817891 |
Serum sickness | 25.62 | 10.09 | 35 | 129192 | 1755 | 29821496 |
Hypertension | 25.56 | 10.09 | 369 | 128858 | 120985 | 29702266 |
Balance disorder | 25.39 | 10.09 | 77 | 129150 | 36416 | 29786835 |
Idiopathic pulmonary fibrosis | 25.37 | 10.09 | 55 | 129172 | 4014 | 29819237 |
Osteoarthritis | 25.36 | 10.09 | 25 | 129202 | 18324 | 29804927 |
Flushing | 25.30 | 10.09 | 56 | 129171 | 29436 | 29793815 |
Blood fibrinogen decreased | 25.26 | 10.09 | 26 | 129201 | 963 | 29822288 |
Renal impairment | 25.06 | 10.09 | 506 | 128721 | 83678 | 29739573 |
Pre-engraftment immune reaction | 25.06 | 10.09 | 11 | 129216 | 89 | 29823162 |
Upper respiratory tract inflammation | 25.00 | 10.09 | 35 | 129192 | 1796 | 29821455 |
Purpura | 24.92 | 10.09 | 97 | 129130 | 9870 | 29813381 |
Dyspepsia | 24.88 | 10.09 | 59 | 129168 | 30270 | 29792981 |
Rash erythematous | 24.81 | 10.09 | 174 | 129053 | 22278 | 29800973 |
Lung transplant rejection | 24.78 | 10.09 | 23 | 129204 | 749 | 29822502 |
Myocardial ischaemia | 24.63 | 10.09 | 23 | 129204 | 17294 | 29805957 |
Arthropathy | 24.55 | 10.09 | 32 | 129195 | 20695 | 29802556 |
Pneumonia pneumococcal | 24.48 | 10.09 | 35 | 129192 | 1832 | 29821419 |
Aplasia pure red cell | 24.30 | 10.09 | 66 | 129161 | 5560 | 29817691 |
Rectal haemorrhage | 24.11 | 10.09 | 74 | 129153 | 34865 | 29788386 |
Vision blurred | 23.87 | 10.09 | 96 | 129131 | 41720 | 29781531 |
Depressed mood | 23.77 | 10.09 | 23 | 129204 | 17006 | 29806245 |
Brain abscess | 23.73 | 10.09 | 42 | 129185 | 2639 | 29820612 |
Bacteraemia | 23.73 | 10.09 | 131 | 129096 | 15429 | 29807822 |
C-reactive protein increased | 23.54 | 10.09 | 289 | 128938 | 43184 | 29780067 |
Genital erythema | 23.17 | 10.09 | 12 | 129215 | 145 | 29823106 |
Cytomegalovirus enterocolitis | 23.13 | 10.09 | 23 | 129204 | 817 | 29822434 |
Drug eruption | 23.12 | 10.09 | 142 | 129085 | 17384 | 29805867 |
Multiple sclerosis relapse | 23.02 | 10.09 | 9 | 129218 | 10853 | 29812398 |
Clear cell renal cell carcinoma | 22.92 | 10.09 | 24 | 129203 | 907 | 29822344 |
Acanthamoeba infection | 22.76 | 10.09 | 18 | 129209 | 469 | 29822782 |
Erythema multiforme | 22.71 | 10.09 | 81 | 129146 | 7904 | 29815347 |
Liver transplant | 22.40 | 10.09 | 42 | 129185 | 2760 | 29820491 |
Organising pneumonia | 22.39 | 10.09 | 60 | 129167 | 5014 | 29818237 |
Pneumonia influenzal | 22.38 | 10.09 | 28 | 129199 | 1287 | 29821964 |
Photosensitivity reaction | 22.36 | 10.09 | 92 | 129135 | 9602 | 29813649 |
Transient ischaemic attack | 22.32 | 10.09 | 47 | 129180 | 25153 | 29798098 |
Nephropathy toxic | 22.24 | 10.09 | 98 | 129129 | 10541 | 29812710 |
Graft versus host disease in skin | 22.12 | 10.09 | 46 | 129181 | 3261 | 29819990 |
Isosporiasis | 22.06 | 10.09 | 10 | 129217 | 88 | 29823163 |
Type 2 diabetes mellitus | 21.96 | 10.09 | 16 | 129211 | 13606 | 29809645 |
Product substitution issue | 21.79 | 10.09 | 8 | 129219 | 10027 | 29813224 |
Coma | 21.77 | 10.09 | 95 | 129132 | 40354 | 29782897 |
Intentional self-injury | 21.68 | 10.09 | 16 | 129211 | 13516 | 29809735 |
Cerebral aspergillosis | 21.66 | 10.09 | 28 | 129199 | 1330 | 29821921 |
Glycosylated haemoglobin increased | 21.59 | 10.09 | 7 | 129220 | 9484 | 29813767 |
Hyperbilirubinaemia | 21.55 | 10.09 | 136 | 129091 | 16806 | 29806445 |
Granuloma skin | 21.42 | 10.09 | 14 | 129213 | 268 | 29822983 |
Mental disorder | 21.42 | 10.09 | 16 | 129211 | 13433 | 29809818 |
Pericarditis fungal | 21.38 | 10.09 | 12 | 129215 | 172 | 29823079 |
Neck pain | 21.24 | 10.09 | 36 | 129191 | 20908 | 29802343 |
Obliterative bronchiolitis | 21.17 | 10.09 | 26 | 129201 | 1172 | 29822079 |
Pseudomonal bacteraemia | 21.17 | 10.09 | 22 | 129205 | 824 | 29822427 |
Weight decreased | 21.08 | 10.09 | 493 | 128734 | 150428 | 29672823 |
Drug resistance | 21.07 | 10.09 | 154 | 129073 | 19979 | 29803272 |
Vogt-Koyanagi-Harada disease | 21.03 | 10.09 | 9 | 129218 | 68 | 29823183 |
Diffuse large B-cell lymphoma | 21.00 | 10.09 | 78 | 129149 | 7763 | 29815488 |
Arteriosclerosis coronary artery | 20.97 | 10.09 | 11 | 129216 | 11165 | 29812086 |
Herpes simplex | 20.94 | 10.09 | 54 | 129173 | 4410 | 29818841 |
Coronary artery occlusion | 20.90 | 10.09 | 11 | 129216 | 11146 | 29812105 |
Oesophageal candidiasis | 20.86 | 10.09 | 52 | 129175 | 4158 | 29819093 |
Cheilitis | 20.82 | 10.09 | 36 | 129191 | 2220 | 29821031 |
Serotonin syndrome | 20.81 | 10.09 | 28 | 129199 | 17863 | 29805388 |
Hepatosplenomegaly | 20.80 | 10.09 | 48 | 129179 | 3653 | 29819598 |
Road traffic accident | 20.59 | 10.09 | 26 | 129201 | 17045 | 29806206 |
Granuloma | 20.57 | 10.09 | 37 | 129190 | 2355 | 29820896 |
Blood antidiuretic hormone increased | 20.48 | 10.09 | 9 | 129218 | 73 | 29823178 |
Demodicidosis | 20.47 | 10.09 | 11 | 129216 | 144 | 29823107 |
Accidental exposure to product | 20.44 | 10.09 | 9 | 129218 | 10106 | 29813145 |
Substance abuse | 20.43 | 10.09 | 3 | 129224 | 7037 | 29816214 |
Gastroenteritis cryptosporidial | 20.40 | 10.09 | 12 | 129215 | 189 | 29823062 |
Aphthous ulcer | 20.37 | 10.09 | 51 | 129176 | 4090 | 29819161 |
Pneumocystis jirovecii infection | 20.32 | 10.09 | 27 | 129200 | 1318 | 29821933 |
Device malfunction | 20.27 | 10.09 | 5 | 129222 | 8106 | 29815145 |
Necrotising retinitis | 20.24 | 10.09 | 20 | 129207 | 705 | 29822546 |
Kidney fibrosis | 20.21 | 10.09 | 34 | 129193 | 2051 | 29821200 |
Cytomegalovirus chorioretinitis | 20.18 | 10.09 | 44 | 129183 | 3224 | 29820027 |
Conjunctivalisation | 20.16 | 10.09 | 6 | 129221 | 12 | 29823239 |
Hepatitis fulminant | 19.87 | 10.09 | 49 | 129178 | 3892 | 29819359 |
Escherichia urinary tract infection | 19.87 | 10.09 | 41 | 129186 | 2891 | 29820360 |
Acquired immunodeficiency syndrome | 19.84 | 10.09 | 17 | 129210 | 497 | 29822754 |
Oroantral fistula | 19.79 | 10.09 | 13 | 129214 | 251 | 29823000 |
Migraine | 19.64 | 10.09 | 16 | 129211 | 12858 | 29810393 |
Meningitis cryptococcal | 19.61 | 10.09 | 33 | 129194 | 1991 | 29821260 |
Acute graft versus host disease in skin | 19.53 | 10.09 | 53 | 129174 | 4463 | 29818788 |
Scopulariopsis infection | 19.52 | 10.09 | 10 | 129217 | 118 | 29823133 |
Head injury | 19.43 | 10.09 | 27 | 129200 | 16993 | 29806258 |
Injection site bruising | 19.39 | 10.09 | 4 | 129223 | 7334 | 29815917 |
Angina unstable | 19.15 | 10.09 | 15 | 129212 | 12295 | 29810956 |
Muscle spasms | 19.12 | 10.09 | 183 | 129044 | 64655 | 29758596 |
Dyskinesia | 19.11 | 10.09 | 41 | 129186 | 21793 | 29801458 |
Disseminated intravascular coagulation | 19.02 | 10.09 | 162 | 129065 | 22009 | 29801242 |
Parvovirus infection | 19.02 | 10.09 | 16 | 129211 | 456 | 29822795 |
Sleep apnoea syndrome | 18.98 | 10.09 | 27 | 129200 | 16830 | 29806421 |
Renal tubular disorder | 18.96 | 10.09 | 56 | 129171 | 4950 | 29818301 |
Pulmonary alveolar haemorrhage | 18.92 | 10.09 | 67 | 129160 | 6514 | 29816737 |
Splenomegaly | 18.92 | 10.09 | 111 | 129116 | 13369 | 29809882 |
Granulomatous dermatitis | 18.81 | 10.09 | 12 | 129215 | 220 | 29823031 |
Bicytopenia | 18.79 | 10.09 | 30 | 129197 | 1732 | 29821519 |
Cytopenia | 18.76 | 10.09 | 78 | 129149 | 8178 | 29815073 |
Unevaluable event | 18.76 | 10.09 | 72 | 129155 | 31713 | 29791538 |
Pneumonitis | 18.73 | 10.09 | 191 | 129036 | 27263 | 29795988 |
Restlessness | 18.50 | 10.09 | 44 | 129183 | 22555 | 29800696 |
Gastrooesophageal reflux disease | 18.44 | 10.09 | 74 | 129153 | 32181 | 29791070 |
Confusional state | 18.39 | 10.09 | 442 | 128785 | 134392 | 29688859 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 18.36 | 10.09 | 15 | 129212 | 410 | 29822841 |
Schizophrenia | 18.36 | 10.09 | 8 | 129219 | 9040 | 29814211 |
Escherichia infection | 18.24 | 10.09 | 65 | 129162 | 6340 | 29816911 |
Proteus infection | 18.17 | 10.09 | 19 | 129208 | 717 | 29822534 |
Delusion | 18.16 | 10.09 | 15 | 129212 | 11974 | 29811277 |
Nephrogenic diabetes insipidus | 18.10 | 10.09 | 24 | 129203 | 1169 | 29822082 |
Epstein-Barr viraemia | 18.03 | 10.09 | 21 | 129206 | 895 | 29822356 |
Cytomegalovirus infection reactivation | 18.01 | 10.09 | 29 | 129198 | 1686 | 29821565 |
Anger | 18.01 | 10.09 | 13 | 129214 | 11107 | 29812144 |
Klebsiella sepsis | 17.99 | 10.09 | 29 | 129198 | 1688 | 29821563 |
Pulmonary mucormycosis | 17.94 | 10.09 | 15 | 129212 | 424 | 29822827 |
Incorrect dose administered | 17.92 | 10.09 | 73 | 129154 | 31613 | 29791638 |
Polyomavirus viraemia | 17.89 | 10.09 | 16 | 129211 | 496 | 29822755 |
Enterovirus infection | 17.88 | 10.09 | 17 | 129210 | 571 | 29822680 |
Abnormal behaviour | 17.87 | 10.09 | 54 | 129173 | 25569 | 29797682 |
Blood HIV RNULL increased | 17.77 | 10.09 | 26 | 129201 | 1390 | 29821861 |
Paranoia | 17.72 | 10.09 | 11 | 129216 | 10177 | 29813074 |
Product prescribing error | 17.68 | 10.09 | 28 | 129199 | 16705 | 29806546 |
Tumour flare | 17.57 | 10.09 | 16 | 129211 | 508 | 29822743 |
Musculoskeletal discomfort | 17.57 | 10.09 | 3 | 129224 | 6297 | 29816954 |
Meningitis aseptic | 17.57 | 10.09 | 34 | 129193 | 2288 | 29820963 |
Hypersensitivity myocarditis | 17.49 | 10.09 | 8 | 129219 | 72 | 29823179 |
Lymphoproliferative disorder | 17.49 | 10.09 | 34 | 129193 | 2296 | 29820955 |
Protothecosis | 17.44 | 10.09 | 7 | 129220 | 44 | 29823207 |
Tooth deposit | 17.43 | 10.09 | 9 | 129218 | 108 | 29823143 |
Nasopharyngitis | 17.39 | 10.09 | 166 | 129061 | 58683 | 29764568 |
Lung infiltration | 17.35 | 10.09 | 103 | 129124 | 12456 | 29810795 |
Arthritis | 17.32 | 10.09 | 51 | 129176 | 24350 | 29798901 |
Peripheral swelling | 17.32 | 10.09 | 174 | 129053 | 60900 | 29762351 |
Fungaemia | 17.29 | 10.09 | 33 | 129194 | 2198 | 29821053 |
Staphylococcal infection | 17.27 | 10.09 | 203 | 129024 | 30021 | 29793230 |
Encephalitis | 17.21 | 10.09 | 64 | 129163 | 6372 | 29816879 |
Enterococcal sepsis | 17.14 | 10.09 | 27 | 129200 | 1541 | 29821710 |
Arteriosclerosis | 17.11 | 10.09 | 13 | 129214 | 10820 | 29812431 |
Pseudomembranous colitis | 17.01 | 10.09 | 38 | 129189 | 2830 | 29820421 |
Cerebral toxoplasmosis | 17 | 10.09 | 26 | 129201 | 1446 | 29821805 |
Hypercalcaemia | 16.96 | 10.09 | 102 | 129125 | 12393 | 29810858 |
Infective thrombosis | 16.85 | 10.09 | 8 | 129219 | 79 | 29823172 |
Haemorrhage | 16.77 | 10.09 | 123 | 129104 | 45956 | 29777295 |
Hypoxia | 16.77 | 10.09 | 295 | 128932 | 47559 | 29775692 |
CD4 lymphocytes increased | 16.76 | 10.09 | 12 | 129215 | 268 | 29822983 |
Achromobacter infection | 16.57 | 10.09 | 7 | 129220 | 51 | 29823200 |
Conjunctival irritation | 16.54 | 10.09 | 9 | 129218 | 121 | 29823130 |
Myalgia | 16.52 | 10.09 | 232 | 128995 | 76435 | 29746816 |
Lung disorder | 16.52 | 10.09 | 208 | 129019 | 31261 | 29791990 |
Blood pressure decreased | 16.50 | 10.09 | 127 | 129100 | 46948 | 29776303 |
Chronic graft versus host disease | 16.49 | 10.09 | 47 | 129180 | 4072 | 29819179 |
Fracture | 16.45 | 10.09 | 3 | 129224 | 6003 | 29817248 |
Sphincter of Oddi dysfunction | 16.35 | 10.09 | 9 | 129218 | 124 | 29823127 |
Chills | 16.27 | 10.09 | 418 | 128809 | 71920 | 29751331 |
Dermatophytosis | 16.24 | 10.09 | 11 | 129216 | 224 | 29823027 |
Cardiovascular disorder | 16.23 | 10.09 | 14 | 129213 | 10938 | 29812313 |
Swelling | 16.18 | 10.09 | 90 | 129137 | 35885 | 29787366 |
Respiratory tract infection fungal | 16.16 | 10.09 | 17 | 129210 | 646 | 29822605 |
Mantle cell lymphoma | 16.11 | 10.09 | 26 | 129201 | 1515 | 29821736 |
Clostridium difficile infection | 16.10 | 10.09 | 120 | 129107 | 15663 | 29807588 |
Poikiloderma | 16.08 | 10.09 | 10 | 129217 | 175 | 29823076 |
Polymyositis | 16.07 | 10.09 | 25 | 129202 | 1411 | 29821840 |
Pulmonary sarcoidosis | 16.05 | 10.09 | 16 | 129211 | 570 | 29822681 |
Folliculitis | 16.02 | 10.09 | 43 | 129184 | 3597 | 29819654 |
Disseminated trichosporonosis | 16.01 | 10.09 | 7 | 129220 | 56 | 29823195 |
Fungal infection | 15.97 | 10.09 | 107 | 129120 | 13493 | 29809758 |
Skull malformation | 15.95 | 10.09 | 13 | 129214 | 354 | 29822897 |
HIV infection | 15.90 | 10.09 | 27 | 129200 | 1641 | 29821610 |
Respiratory tract infection | 15.87 | 10.09 | 118 | 129109 | 15388 | 29807863 |
Rash pruritic | 15.86 | 10.09 | 158 | 129069 | 22414 | 29800837 |
Leukaemia recurrent | 15.86 | 10.09 | 26 | 129201 | 1535 | 29821716 |
Injection site haemorrhage | 15.85 | 10.09 | 7 | 129220 | 7848 | 29815403 |
Injection site erythema | 15.73 | 10.09 | 22 | 129205 | 13812 | 29809439 |
Neurotoxicity | 15.65 | 10.09 | 104 | 129123 | 13078 | 29810173 |
Klebsiella bacteraemia | 15.63 | 10.09 | 21 | 129206 | 1036 | 29822215 |
Escherichia bacteraemia | 15.61 | 10.09 | 37 | 129190 | 2865 | 29820386 |
Palmar-plantar erythrodysaesthesia syndrome | 15.60 | 10.09 | 25 | 129202 | 14845 | 29808406 |
Visual impairment | 15.47 | 10.09 | 73 | 129154 | 30365 | 29792886 |
Escherichia sepsis | 15.43 | 10.09 | 45 | 129182 | 3949 | 29819302 |
Acute graft versus host disease | 15.42 | 10.09 | 58 | 129169 | 5806 | 29817445 |
Vascular pseudoaneurysm thrombosis | 15.40 | 10.09 | 7 | 129220 | 62 | 29823189 |
Interstitial lung disease | 15.39 | 10.09 | 354 | 128873 | 59843 | 29763408 |
Serum ferritin increased | 15.33 | 10.09 | 55 | 129172 | 5382 | 29817869 |
Lymphadenitis | 15.29 | 10.09 | 27 | 129200 | 1693 | 29821558 |
Bacterial infection | 15.29 | 10.09 | 100 | 129127 | 12510 | 29810741 |
Mycobacterial infection | 15.28 | 10.09 | 27 | 129200 | 1694 | 29821557 |
Atypical mycobacterial infection | 15.22 | 10.09 | 18 | 129209 | 780 | 29822471 |
Gastritis fungal | 15.21 | 10.09 | 8 | 129219 | 100 | 29823151 |
Lethargy | 15.11 | 10.09 | 104 | 129123 | 39415 | 29783836 |
Joint stiffness | 15.08 | 10.09 | 11 | 129216 | 9350 | 29813901 |
Haematemesis | 15.05 | 10.09 | 60 | 129167 | 26143 | 29797108 |
Lichenoid keratosis | 15.04 | 10.09 | 30 | 129197 | 2064 | 29821187 |
Chronic papillomatous dermatitis | 15.02 | 10.09 | 7 | 129220 | 66 | 29823185 |
Platelet transfusion | 15.02 | 10.09 | 20 | 129207 | 978 | 29822273 |
Hepatitis A | 14.95 | 10.09 | 14 | 129213 | 461 | 29822790 |
Phlebitis infective | 14.91 | 10.09 | 9 | 129218 | 149 | 29823102 |
Neutrophilic dermatosis | 14.79 | 10.09 | 10 | 129217 | 203 | 29823048 |
Portal fibrosis | 14.78 | 10.09 | 13 | 129214 | 394 | 29822857 |
Prostatic specific antigen increased | 14.77 | 10.09 | 18 | 129209 | 11986 | 29811265 |
Musculoskeletal pain | 14.69 | 10.09 | 76 | 129151 | 30864 | 29792387 |
Mobility decreased | 14.64 | 10.09 | 60 | 129167 | 25939 | 29797312 |
Hyperphosphataemia | 14.62 | 10.09 | 31 | 129196 | 2228 | 29821023 |
Streptococcal bacteraemia | 14.57 | 10.09 | 26 | 129201 | 1644 | 29821607 |
Psychotic disorder | 14.54 | 10.09 | 46 | 129181 | 21469 | 29801782 |
Haptoglobin decreased | 14.50 | 10.09 | 15 | 129212 | 559 | 29822692 |
Immunodeficiency common variable | 14.45 | 10.09 | 9 | 129218 | 158 | 29823093 |
Paradoxical drug reaction | 14.39 | 10.09 | 34 | 129193 | 2628 | 29820623 |
Osteoporotic fracture | 14.33 | 10.09 | 20 | 129207 | 1023 | 29822228 |
Anal inflammation | 14.32 | 10.09 | 12 | 129215 | 340 | 29822911 |
Emotional distress | 14.30 | 10.09 | 29 | 129198 | 15736 | 29807515 |
Cold sweat | 14.21 | 10.09 | 11 | 129216 | 9071 | 29814180 |
Asterixis | 14.21 | 10.09 | 22 | 129205 | 1237 | 29822014 |
Immunosuppressant drug level decreased | 14.21 | 10.09 | 22 | 129205 | 1237 | 29822014 |
Dyspnoea exertional | 14.16 | 10.09 | 92 | 129135 | 35338 | 29787913 |
Lower respiratory tract infection fungal | 14.13 | 10.09 | 15 | 129212 | 576 | 29822675 |
Differentiation syndrome | 14.12 | 10.09 | 21 | 129206 | 1139 | 29822112 |
Faeces discoloured | 14.12 | 10.09 | 24 | 129203 | 13922 | 29809329 |
Peritonitis bacterial | 14.07 | 10.09 | 17 | 129210 | 11361 | 29811890 |
Cholestatic liver injury | 14.07 | 10.09 | 25 | 129202 | 1576 | 29821675 |
Renal tubular atrophy | 14.06 | 10.09 | 20 | 129207 | 1042 | 29822209 |
Conjunctivitis | 14.02 | 10.09 | 70 | 129157 | 7930 | 29815321 |
Acute respiratory distress syndrome | 14.01 | 10.09 | 159 | 129068 | 23313 | 29799938 |
Alcohol abuse | 13.97 | 10.09 | 3 | 129224 | 5350 | 29817901 |
Blood bilirubin unconjugated increased | 13.96 | 10.09 | 16 | 129211 | 670 | 29822581 |
Coombs direct test positive | 13.93 | 10.09 | 11 | 129216 | 286 | 29822965 |
Steroid diabetes | 13.92 | 10.09 | 22 | 129205 | 1259 | 29821992 |
Haemoglobinaemia | 13.92 | 10.09 | 9 | 129218 | 169 | 29823082 |
Incorrect route of product administration | 13.89 | 10.09 | 17 | 129210 | 11298 | 29811953 |
Prescribed overdose | 13.87 | 10.09 | 10 | 129217 | 8551 | 29814700 |
Multiple sclerosis | 13.86 | 10.09 | 7 | 129220 | 7260 | 29815991 |
Paraspinal abscess | 13.86 | 10.09 | 7 | 129220 | 80 | 29823171 |
Postural tremor | 13.83 | 10.09 | 11 | 129216 | 289 | 29822962 |
Stenotrophomonas infection | 13.81 | 10.09 | 25 | 129202 | 1599 | 29821652 |
Amnesia | 13.78 | 10.09 | 56 | 129171 | 24265 | 29798986 |
Irritability | 13.74 | 10.09 | 52 | 129175 | 22998 | 29800253 |
Cardiogenic shock | 13.67 | 10.09 | 33 | 129194 | 16828 | 29806423 |
Mucosal infection | 13.64 | 10.09 | 10 | 129217 | 232 | 29823019 |
Hypoaldosteronism | 13.60 | 10.09 | 9 | 129218 | 176 | 29823075 |
Hyponatraemia | 13.59 | 10.09 | 383 | 128844 | 66819 | 29756432 |
Pulmonary physical examination abnormal | 13.57 | 10.09 | 5 | 129222 | 24 | 29823227 |
Systemic infection | 13.51 | 10.09 | 16 | 129211 | 694 | 29822557 |
Subcapsular renal haematoma | 13.39 | 10.09 | 12 | 129215 | 373 | 29822878 |
Discomfort | 13.37 | 10.09 | 26 | 129201 | 14330 | 29808921 |
Muscle spasticity | 13.36 | 10.09 | 3 | 129224 | 5185 | 29818066 |
Dysphonia | 13.35 | 10.09 | 40 | 129187 | 18992 | 29804259 |
Sinusitis bacterial | 13.30 | 10.09 | 11 | 129216 | 306 | 29822945 |
Injection site swelling | 13.28 | 10.09 | 11 | 129216 | 8769 | 29814482 |
Peripheral arterial occlusive disease | 13.28 | 10.09 | 3 | 129224 | 5165 | 29818086 |
Pemphigoid | 13.27 | 10.09 | 8 | 129219 | 7520 | 29815731 |
Anhedonia | 13.27 | 10.09 | 10 | 129217 | 8359 | 29814892 |
Adverse event | 13.26 | 10.09 | 29 | 129198 | 15312 | 29807939 |
Graft versus host disease in gastrointestinal tract | 13.25 | 10.09 | 36 | 129191 | 3033 | 29820218 |
Blood bilirubin increased | 13.25 | 10.09 | 227 | 129000 | 36409 | 29786842 |
Hepatotoxicity | 13.23 | 10.09 | 128 | 129099 | 18017 | 29805234 |
Pseudohyponatraemia | 13.21 | 10.09 | 7 | 129220 | 89 | 29823162 |
Angina pectoris | 13.19 | 10.09 | 74 | 129153 | 29444 | 29793807 |
Bacterial sepsis | 13.19 | 10.09 | 49 | 129178 | 4877 | 29818374 |
Polyglandular autoimmune syndrome type III | 13.13 | 10.09 | 4 | 129223 | 9 | 29823242 |
Seizure | 13.09 | 10.09 | 324 | 128903 | 98151 | 29725100 |
Urinary incontinence | 13.07 | 10.09 | 34 | 129193 | 16906 | 29806345 |
Wheezing | 13.06 | 10.09 | 79 | 129148 | 30859 | 29792392 |
Distributive shock | 13.03 | 10.09 | 15 | 129212 | 631 | 29822620 |
Brief psychotic disorder with marked stressors | 12.96 | 10.09 | 8 | 129219 | 138 | 29823113 |
Nightmare | 12.96 | 10.09 | 20 | 129207 | 12056 | 29811195 |
Limb discomfort | 12.89 | 10.09 | 12 | 129215 | 9038 | 29814213 |
Gastroenteritis adenovirus | 12.87 | 10.09 | 7 | 129220 | 94 | 29823157 |
Heart rate increased | 12.85 | 10.09 | 106 | 129121 | 38615 | 29784636 |
Pulpitis dental | 12.84 | 10.09 | 12 | 129215 | 394 | 29822857 |
Hypertensive emergency | 12.84 | 10.09 | 17 | 129210 | 827 | 29822424 |
Peripheral sensory neuropathy | 12.83 | 10.09 | 55 | 129172 | 5846 | 29817405 |
Mycobacterium fortuitum infection | 12.77 | 10.09 | 9 | 129218 | 196 | 29823055 |
International normalised ratio increased | 12.72 | 10.09 | 138 | 129089 | 47601 | 29775650 |
Miosis | 12.71 | 10.09 | 9 | 129218 | 7767 | 29815484 |
Sexual dysfunction | 12.67 | 10.09 | 5 | 129222 | 5996 | 29817255 |
Mantle cell lymphoma refractory | 12.62 | 10.09 | 7 | 129220 | 98 | 29823153 |
Alanine aminotransferase abnormal | 12.61 | 10.09 | 32 | 129195 | 2587 | 29820664 |
Therapeutic response decreased | 12.61 | 10.09 | 58 | 129169 | 24291 | 29798960 |
Botulism | 12.57 | 10.09 | 9 | 129218 | 201 | 29823050 |
Systemic candida | 12.52 | 10.09 | 33 | 129194 | 2731 | 29820520 |
Type 3 diabetes mellitus | 12.51 | 10.09 | 5 | 129222 | 31 | 29823220 |
Premature baby | 12.50 | 10.09 | 34 | 129193 | 16657 | 29806594 |
Mycobacterium abscessus infection | 12.45 | 10.09 | 14 | 129213 | 574 | 29822677 |
Product storage error | 12.43 | 10.09 | 6 | 129221 | 6385 | 29816866 |
Human ehrlichiosis | 12.42 | 10.09 | 9 | 129218 | 205 | 29823046 |
Fixed eruption | 12.41 | 10.09 | 20 | 129207 | 1164 | 29822087 |
Lymphocytic infiltration | 12.37 | 10.09 | 14 | 129213 | 578 | 29822673 |
Varicella | 12.31 | 10.09 | 23 | 129204 | 1507 | 29821744 |
Bladder spasm | 12.31 | 10.09 | 17 | 129210 | 861 | 29822390 |
Ischaemic stroke | 12.31 | 10.09 | 33 | 129194 | 16242 | 29807009 |
Infective pulmonary exacerbation of cystic fibrosis | 12.30 | 10.09 | 71 | 129156 | 8501 | 29814750 |
Dysarthria | 12.27 | 10.09 | 79 | 129148 | 30411 | 29792840 |
Asymptomatic COVID-19 | 12.25 | 10.09 | 5 | 129222 | 33 | 29823218 |
Acute lymphocytic leukaemia recurrent | 12.24 | 10.09 | 32 | 129195 | 2635 | 29820616 |
Electrocardiogram T wave peaked | 12.21 | 10.09 | 13 | 129214 | 501 | 29822750 |
Peripheral motor neuropathy | 12.20 | 10.09 | 24 | 129203 | 1635 | 29821616 |
Prothrombin level abnormal | 12.20 | 10.09 | 7 | 129220 | 105 | 29823146 |
Cardiac failure chronic | 12.19 | 10.09 | 5 | 129222 | 5858 | 29817393 |
Skin candida | 12.17 | 10.09 | 13 | 129214 | 503 | 29822748 |
Urinoma | 12.16 | 10.09 | 9 | 129218 | 212 | 29823039 |
Respiratory syncytial virus infection | 12.12 | 10.09 | 37 | 129190 | 3331 | 29819920 |
Ischaemic cardiomyopathy | 12.11 | 10.09 | 6 | 129221 | 6291 | 29816960 |
Citrobacter infection | 12.11 | 10.09 | 13 | 129214 | 506 | 29822745 |
Myelosuppression | 12.08 | 10.09 | 63 | 129164 | 7259 | 29815992 |
Pneumatosis intestinalis | 12.06 | 10.09 | 32 | 129195 | 2658 | 29820593 |
Salivary hypersecretion | 12.05 | 10.09 | 9 | 129218 | 7557 | 29815694 |
High-grade B-cell lymphoma | 12.02 | 10.09 | 8 | 129219 | 158 | 29823093 |
Jaundice | 12.00 | 10.09 | 202 | 129025 | 32284 | 29790967 |
Babesiosis | 12.00 | 10.09 | 6 | 129221 | 67 | 29823184 |
Product complaint | 11.99 | 10.09 | 5 | 129222 | 5801 | 29817450 |
Glomerulonephritis rapidly progressive | 11.98 | 10.09 | 12 | 129215 | 430 | 29822821 |
Computerised tomogram thorax abnormal | 11.93 | 10.09 | 15 | 129212 | 693 | 29822558 |
Hyperpyrexia | 11.91 | 10.09 | 31 | 129196 | 2546 | 29820705 |
Middle insomnia | 11.88 | 10.09 | 5 | 129222 | 5768 | 29817483 |
Encephalopathy | 11.81 | 10.09 | 200 | 129027 | 32005 | 29791246 |
Biopsy liver abnormal | 11.81 | 10.09 | 8 | 129219 | 163 | 29823088 |
Hypoglycaemia | 11.80 | 10.09 | 152 | 129075 | 50829 | 29772422 |
Priapism | 11.70 | 10.09 | 3 | 129224 | 4740 | 29818511 |
Pyelonephritis acute | 11.66 | 10.09 | 23 | 129204 | 1570 | 29821681 |
Trichophytic granuloma | 11.62 | 10.09 | 6 | 129221 | 72 | 29823179 |
Surgery | 11.58 | 10.09 | 20 | 129207 | 11531 | 29811720 |
Gait inability | 11.56 | 10.09 | 42 | 129185 | 18799 | 29804452 |
Adenomatous polyposis coli | 11.56 | 10.09 | 8 | 129219 | 169 | 29823082 |
Nausea | 11.53 | 10.09 | 1114 | 128113 | 295843 | 29527408 |
Pericarditis | 11.52 | 10.09 | 70 | 129157 | 8536 | 29814715 |
Cardiac valve vegetation | 11.47 | 10.09 | 12 | 129215 | 453 | 29822798 |
Respiratory depression | 11.46 | 10.09 | 20 | 129207 | 11483 | 29811768 |
Transplant failure | 11.45 | 10.09 | 30 | 129197 | 2474 | 29820777 |
Tuberculosis of central nervous system | 11.44 | 10.09 | 8 | 129219 | 172 | 29823079 |
Coronary artery bypass | 11.40 | 10.09 | 4 | 129223 | 5158 | 29818093 |
Urine protein/creatinine ratio increased | 11.32 | 10.09 | 8 | 129219 | 175 | 29823076 |
Granulomatous rosacea | 11.32 | 10.09 | 8 | 129219 | 175 | 29823076 |
Fontanelle depressed | 11.28 | 10.09 | 3 | 129224 | 3 | 29823248 |
Erythroblast count increased | 11.28 | 10.09 | 3 | 129224 | 3 | 29823248 |
Atypical mycobacterium test positive | 11.28 | 10.09 | 3 | 129224 | 3 | 29823248 |
Alcaligenes infection | 11.28 | 10.09 | 3 | 129224 | 3 | 29823248 |
Hepatitis E | 11.27 | 10.09 | 23 | 129204 | 1609 | 29821642 |
Dementia | 11.24 | 10.09 | 23 | 129204 | 12438 | 29810813 |
Speech disorder | 11.20 | 10.09 | 61 | 129166 | 24451 | 29798800 |
Reactive gastropathy | 11.16 | 10.09 | 8 | 129219 | 179 | 29823072 |
Colitis | 11.15 | 10.09 | 191 | 129036 | 30629 | 29792622 |
Panniculitis | 11.14 | 10.09 | 16 | 129211 | 841 | 29822410 |
Parkinsonism | 11.13 | 10.09 | 9 | 129218 | 7260 | 29815991 |
Optic discs blurred | 11.07 | 10.09 | 6 | 129221 | 80 | 29823171 |
Lactic acidosis | 11.03 | 10.09 | 84 | 129143 | 31129 | 29792122 |
Blood glucose decreased | 11.02 | 10.09 | 25 | 129202 | 13028 | 29810223 |
Mastitis | 11.01 | 10.09 | 8 | 129219 | 183 | 29823068 |
Central nervous system infection | 10.99 | 10.09 | 12 | 129215 | 476 | 29822775 |
Mania | 10.98 | 10.09 | 14 | 129213 | 9140 | 29814111 |
Eye infection fungal | 10.92 | 10.09 | 10 | 129217 | 320 | 29822931 |
Muscular weakness | 10.90 | 10.09 | 201 | 129026 | 63444 | 29759807 |
Cyclosporidium infection | 10.89 | 10.09 | 4 | 129223 | 19 | 29823232 |
Heart rate decreased | 10.87 | 10.09 | 50 | 129177 | 20944 | 29802307 |
Skin exfoliation | 10.84 | 10.09 | 150 | 129077 | 23022 | 29800229 |
Renal graft infection | 10.83 | 10.09 | 9 | 129218 | 252 | 29822999 |
Withdrawal syndrome | 10.81 | 10.09 | 20 | 129207 | 11230 | 29812021 |
Akathisia | 10.80 | 10.09 | 6 | 129221 | 5898 | 29817353 |
Pneumothorax | 10.73 | 10.09 | 112 | 129115 | 16081 | 29807170 |
Limbal stem cell deficiency | 10.72 | 10.09 | 4 | 129223 | 20 | 29823231 |
Eschar | 10.69 | 10.09 | 13 | 129214 | 580 | 29822671 |
Asphyxia | 10.69 | 10.09 | 5 | 129222 | 5420 | 29817831 |
Respiratory syncytial virus test positive | 10.68 | 10.09 | 9 | 129218 | 257 | 29822994 |
Brain compression | 10.68 | 10.09 | 8 | 129219 | 192 | 29823059 |
T-cell prolymphocytic leukaemia | 10.65 | 10.09 | 5 | 129222 | 48 | 29823203 |
No reaction on previous exposure to drug | 10.63 | 10.09 | 6 | 129221 | 87 | 29823164 |
Metastases to lung | 10.63 | 10.09 | 11 | 129216 | 7884 | 29815367 |
Amyotrophy | 10.61 | 10.09 | 12 | 129215 | 495 | 29822756 |
Unmasking of previously unidentified disease | 10.60 | 10.09 | 13 | 129214 | 585 | 29822666 |
Immune recovery uveitis | 10.56 | 10.09 | 4 | 129223 | 21 | 29823230 |
Swollen tongue | 10.55 | 10.09 | 26 | 129201 | 13166 | 29810085 |
Urinary tract infection | 10.55 | 10.09 | 403 | 128824 | 73256 | 29749995 |
Dystonia | 10.54 | 10.09 | 16 | 129211 | 9711 | 29813540 |
Polyarteritis nodosa | 10.54 | 10.09 | 9 | 129218 | 262 | 29822989 |
Cardiomegaly | 10.54 | 10.09 | 30 | 129197 | 14479 | 29808772 |
Internal haemorrhage | 10.53 | 10.09 | 3 | 129224 | 4419 | 29818832 |
Acinetobacter infection | 10.50 | 10.09 | 17 | 129210 | 993 | 29822258 |
Subcutaneous abscess | 10.49 | 10.09 | 36 | 129191 | 3445 | 29819806 |
Pain in jaw | 10.49 | 10.09 | 23 | 129204 | 12133 | 29811118 |
Bacterial pyelonephritis | 10.48 | 10.09 | 9 | 129218 | 264 | 29822987 |
Granulocytopenia | 10.45 | 10.09 | 7 | 129220 | 6219 | 29817032 |
Nervousness | 10.43 | 10.09 | 22 | 129205 | 11766 | 29811485 |
Skin bacterial infection | 10.39 | 10.09 | 5 | 129222 | 51 | 29823200 |
Nephritis | 10.39 | 10.09 | 26 | 129201 | 2084 | 29821167 |
Presyncope | 10.38 | 10.09 | 35 | 129192 | 16021 | 29807230 |
Septic embolus | 10.33 | 10.09 | 18 | 129209 | 1117 | 29822134 |
Hospitalisation | 10.31 | 10.09 | 132 | 129095 | 44187 | 29779064 |
Flavobacterium infection | 10.28 | 10.09 | 6 | 129221 | 93 | 29823158 |
Mixed liver injury | 10.28 | 10.09 | 25 | 129202 | 1968 | 29821283 |
Acute graft versus host disease in intestine | 10.17 | 10.09 | 28 | 129199 | 2377 | 29820874 |
Otitis externa | 10.17 | 10.09 | 17 | 129210 | 1020 | 29822231 |
Pancreatitis necrotising | 10.14 | 10.09 | 28 | 129199 | 2381 | 29820870 |
Peripheral T-cell lymphoma unspecified recurrent | 10.14 | 10.09 | 5 | 129222 | 54 | 29823197 |
Hepatitis B antibody positive | 10.14 | 10.09 | 5 | 129222 | 54 | 29823197 |
Source | Code | Description |
---|---|---|
ATC | J01EC01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Intermediate-acting sulfonamides |
ATC | J01EE01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Combinations of sulfonamides and trimethoprim, incl. derivatives |
ATC | J04AM08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Combinations of drugs for treatment of tuberculosis |
FDA CS | M0020790 | Sulfonamides |
FDA EPC | N0000175504 | Sulfonamide Antimicrobial |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:33281 | antibiotics |
CHEBI has role | CHEBI:33282 | antibacterials |
CHEBI has role | CHEBI:35441 | anti-infective drugs |
CHEBI has role | CHEBI:35703 | xenobiotic |
CHEBI has role | CHEBI:50183 | cytochrome p450 inhibitor |
CHEBI has role | CHEBI:50502 | dihydropteroate synthase inhibitor |
CHEBI has role | CHEBI:53000 | epitope function |
CHEBI has role | CHEBI:74234 | 7,8-dihydrobiopterin:nadp(+) oxidoreductase |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
FDA MoA | N0000185504 | Cytochrome P450 2C9 Inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Acute otitis media | indication | 3110003 | |
Nocardiosis | indication | 29227009 | DOID:2312 |
Shigellosis | indication | 36188001 | |
Klebsiella cystitis | indication | 60867007 | |
Toxoplasmosis | indication | 187192000 | DOID:9965 |
Chlamydial conjunctivitis | indication | 231861005 | DOID:13800 |
Escherichia coli urinary tract infection | indication | 301011002 | |
Proteus urinary tract infection | indication | 301012009 | |
Bacterial urinary infection | indication | 312124009 | |
Infective otitis media | indication | 312218008 | |
Pneumocystosis jiroveci pneumonia | indication | 415125002 | DOID:11339 |
Acute exacerbation of chronic bronchitis | indication | 425748003 | |
Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
Haemophilus Influenzae Chronic Bronchitis | indication | ||
Aerobic Gram-Positive Cocci Infection | indication | ||
Pneumocystis Carinii Pneumonia Prevention | indication | ||
Aerobic Gram-Negative Bacillary Infection | indication | ||
Haemophilus Influenzae Acute Otitis Media | indication | ||
Morganella Morganii Urinary Tract Infection | indication | ||
Typhoid fever | off-label use | 4834000 | DOID:13258 |
Infection of skin AND/OR subcutaneous tissue | off-label use | 19824006 | |
Pertussis | off-label use | 27836007 | |
Granuloma inguinale | off-label use | 28867007 | DOID:9113 |
Listeria meningitis | off-label use | 31568009 | DOID:11572 |
Sinusitis | off-label use | 36971009 | |
Whipple's disease | off-label use | 41545003 | DOID:8476 |
Bacterial pneumonia | off-label use | 53084003 | DOID:874 |
Paracoccidioidomycosis | off-label use | 59925007 | DOID:12662 |
Cholera | off-label use | 63650001 | DOID:1498 |
Brucellosis | off-label use | 75702008 | DOID:11077 |
Paratyphoid fever | off-label use | 85904008 | DOID:3055 |
Chlamydial infection | off-label use | 105629000 | |
Infection of bone | off-label use | 111253001 | |
Meningococcus carrier | off-label use | 170486006 | |
Lymphogranuloma venereum | off-label use | 186946009 | DOID:13819 |
Chancroid | off-label use | 266143009 | DOID:13778 |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Bacterial endocarditis | off-label use | 301183007 | |
Toxoplasmosis associated with acquired immunodeficiency syndrome | off-label use | 421666009 | |
Chronic Bacterial Prostatitis | off-label use | ||
Toxoplasmosis Prevention | off-label use | ||
Postexposure Plague Prophylaxis | off-label use | ||
Diabetic Foot Infection | off-label use | ||
Glomerulonephritis | contraindication | 36171008 | DOID:2921 |
Acute hepatitis | contraindication | 37871000 | |
Third trimester pregnancy | contraindication | 41587001 | |
Uremia | contraindication | 44730006 | DOID:4676 |
Megaloblastic anemia due to folate deficiency | contraindication | 85649008 | DOID:14026 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Folic acid deficiency | contraindication | 190633005 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Porphyria | contraindication | 418470004 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 5.79 | acidic |
pKa2 | 2.08 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Dihydropteroate synthase | Enzyme | INHIBITOR | IC50 | 5.33 | CHEMBL | CHEMBL | |||
Bifunctional protein FolC | Enzyme | WOMBAT-PK | |||||||
Dihydrofolate reductase | Enzyme | IC50 | 7 | CHEMBL | |||||
Endothelin-1 receptor | GPCR | IC50 | 5.40 | CHEMBL | |||||
Pol polyprotein | Enzyme | Ki | 8 | CHEMBL |
ID | Source |
---|---|
4017734 | VUID |
N0000146102 | NUI |
D00447 | KEGG_DRUG |
4017734 | VANDF |
C0038689 | UMLSCUI |
CHEBI:9332 | CHEBI |
08D | PDB_CHEM_ID |
CHEMBL443 | ChEMBL_ID |
D013420 | MESH_DESCRIPTOR_UI |
1386 | INN_ID |
DB01015 | DRUGBANK_ID |
JE42381TNV | UNII |
5329 | PUBCHEM_CID |
10933 | IUPHAR_LIGAND_ID |
10180 | RXNORM |
2035 | MMSL |
5526 | MMSL |
d00119 | MMSL |
002827 | NDDF |
363528007 | SNOMEDCT_US |
70047000 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0853 | SUSPENSION | 200 mg | ORAL | NDA | 28 sections |
SULFATRIM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-0854 | SUSPENSION | 200 mg | ORAL | NDA | 28 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0121-4793 | SUSPENSION | 200 mg | ORAL | ANDA | 28 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0440-2406 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-5180 | SUSPENSION | 200 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0527-5181 | SUSPENSION | 200 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0615-0170 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0615-8121 | TABLET | 800 mg | ORAL | ANDA | 26 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9503 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | ANDA | 22 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | ANDA | 22 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9514 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | ANDA | 22 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0703-9526 | INJECTION, SOLUTION, CONCENTRATE | 80 mg | INTRAVENOUS | ANDA | 22 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0904-2725 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-053 | TABLET | 800 mg | ORAL | ANDA | 26 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-092 | TABLET | 800 mg | ORAL | ANDA | 25 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-525 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-926 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-940 | TABLET | 800 mg | ORAL | ANDA | 27 sections |
Sulfamethoxazole and Trimethoprim DS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 12634-177 | TABLET | 800 mg | ORAL | ANDA | 21 sections |
SULFAMETHOXAZOLE and TRIMETHOPRIM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 12634-779 | SUSPENSION | 200 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 16590-210 | TABLET | 800 mg | ORAL | ANDA | 29 sections |
SULFATRIM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17856-0007 | SUSPENSION | 200 mg | ORAL | NDA | 21 sections |
Sulfamethoxazole and Trimethoprim | Human Prescription Drug Label | 2 | 17856-0496 | SUSPENSION | 200 mg | ORAL | ANDA | 26 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17856-0823 | SUSPENSION | 200 mg | ORAL | ANDA | 20 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 17856-5181 | SUSPENSION | 200 mg | ORAL | ANDA | 21 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-125 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-701 | SUSPENSION | 200 mg | ORAL | ANDA | 20 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 33261-148 | TABLET | 800 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 33261-396 | TABLET | 400 mg | ORAL | ANDA | 13 sections |
Sulfamethoxazole and Trimethoprim | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-758 | TABLET | 400 mg | ORAL | ANDA | 13 sections |