Stem definition | Drug id | CAS RN |
---|---|---|
2314 | 14222-60-7 |
Dose | Unit | Route |
---|---|---|
0.75 | g | O |
Property | Value | Reference |
---|---|---|
BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatotoxicity | 83.17 | 44.28 | 21 | 265 | 27205 | 50577633 |
Electrocardiogram QT prolonged | 74.13 | 44.28 | 22 | 264 | 51864 | 50552974 |
Drug resistance | 44.96 | 44.28 | 12 | 274 | 18977 | 50585861 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatotoxicity | 232.28 | 55.86 | 57 | 565 | 17810 | 29556095 |
Electrocardiogram QT prolonged | 100.76 | 55.86 | 35 | 587 | 36102 | 29537803 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Hepatotoxicity | 302.78 | 44.62 | 78 | 923 | 39884 | 64457847 |
Electrocardiogram QT prolonged | 160.45 | 44.62 | 56 | 945 | 79392 | 64418339 |
None
Source | Code | Description |
---|---|---|
ATC | J04AD01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIMYCOBACTERIALS DRUGS FOR TREATMENT OF TUBERCULOSIS Thiocarbamide derivatives |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000995 | Antitubercular Agents |
None
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 11.43 | acidic |
pKa2 | 5.65 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Polyphenol oxidase 2 | Enzyme | IC50 | 5.35 | CHEMBL |
ID | Source |
---|---|
N0000167317 | NUI |
D01195 | KEGG_DRUG |
C0033705 | UMLSCUI |
CHEBI:32066 | CHEBI |
CHEMBL1378024 | ChEMBL_ID |
DB12667 | DRUGBANK_ID |
2031 | INN_ID |
76YOO33643 | UNII |
666418 | PUBCHEM_CID |
8871 | RXNORM |
006706 | NDDF |
703589003 | SNOMEDCT_US |
714517006 | SNOMEDCT_US |
D011515 | MESH_DESCRIPTOR_UI |
None