protionamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2314 14222-60-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prothionamide
  • 2-Propylisonicotinylthioamide
  • 2-Propylthioisonicotinamide
  • protionamid
  • protionamide
Antitubercular agent similar in action and side effects to ETHIONAMIDE. It is used mostly in combination with other agents.
  • Molecular weight: 180.27
  • Formula: C9H12N2S
  • CLOGP: 2.26
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 38.91
  • ALOGS: -2.79
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.75 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatotoxicity 83.11 48.44 21 267 24988 46660786
Electrocardiogram QT prolonged 68.17 48.44 21 267 51304 46634470

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatotoxicity 226.55 46.15 56 571 18089 29933762
Electrocardiogram QT prolonged 97.32 46.15 34 593 35801 29916050

Pharmacologic Action:

SourceCodeDescription
ATC J04AD01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Thiocarbamide derivatives
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000995 Antitubercular Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.43 acidic
pKa2 5.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167317 NUI
D01195 KEGG_DRUG
C0033705 UMLSCUI
CHEBI:32066 CHEBI
666418 PUBCHEM_CID
CHEMBL1378024 ChEMBL_ID
D011515 MESH_DESCRIPTOR_UI
DB12667 DRUGBANK_ID
2031 INN_ID
76YOO33643 UNII
8871 RXNORM
006706 NDDF
703589003 SNOMEDCT_US
714517006 SNOMEDCT_US

Pharmaceutical products:

None