atorvastatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antihyperlipidaemic substances, HMG CoA reductase inhibitors 257 134523-00-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • CI-981
  • CI981
  • atorvastatin calcium hydrate
  • atorvastatin calcium anhydrous
  • atorvastatin
  • atorvastatin acid
  • cardyl
  • atorvastatin calcium
  • atorvastatin calcium trihydrate
A pyrrole and heptanoic acid derivative, HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITOR (statin), and ANTICHOLESTEREMIC AGENT that is used to reduce serum levels of LDL-CHOLESTEROL; APOLIPOPROTEIN B; and TRIGLYCERIDES. It is used to increase serum levels of HDL-CHOLESTEROL in the treatment of HYPERLIPIDEMIAS, and for the prevention of CARDIOVASCULAR DISEASES in patients with multiple risk factors.
  • Molecular weight: 558.65
  • Formula: C33H35FN2O5
  • CLOGP: 4.46
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 4
  • TPSA: 111.79
  • ALOGS: -5.95
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.05 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.02 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1 % Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 12 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.436 Moderate 0.70
caco2-efflux Caco-2 efflux ratio (BA/AB) 12.331 Moderate 0.70
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 12.764 10^-6 cm/s Moderate 0.70
dh-clint Dog hepatocyte intrinsic clearance 5.675 uL/min/10^6 cells Moderate 0.70
dppb Dog plasma protein binding (% unbound) 3.430 % Moderate 0.70
fcs-ppb Fetal calf serum protein binding (% unbound) 9.170 % Moderate 0.70
herg hERG pIC50 4.660 pIC50 Moderate 0.70
hh-clint Human hepatocyte intrinsic clearance 7.816 uL/min/10^6 cells Moderate 0.70
hlm-clint Human liver microsomal intrinsic clearance 34.514 uL/min/mg protein Moderate 0.70
hppb Human plasma protein binding (% unbound) 3.580 % Moderate 0.70
kinase-safety-class ACVR2B,AXL,EIF2AK3,ERBB2,GRK2,ITK,PDK1,PDK2,PDK4,PRKDC 10
kinase-selectivity-class ACVR2B,AXL,GRK2 3
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 19.275 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 8.790 Moderate 0.70
mh-clint Mouse hepatocyte intrinsic clearance 43.752 Moderate 0.70
mppb Mouse plasma protein binding (% unbound) 4.620 Moderate 0.70
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 35.156 Moderate 0.70
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 5.920 % Moderate 0.70
rat-kpuu-brain Rat brain Kpuu 0.007 % High 1
rh-clint Rat hepatocyte intrinsic clearance 19.543 uL/min/10^6 cells Moderate 0.70
rh-fuinc Rat hepatocyte fraction unbound in incubation 38.470 % Moderate 0.70
rppb Rat plasma protein binding (% unbound) 4.030 % Moderate 0.70
solubility-dd Solubility at pH 7.4 in DMSO 937.562 uM Moderate 0.70

Approvals:

DateAgencyCompanyOrphan
Dec. 17, 1996 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myalgia 2263.75 9.32 3615 471779 171510 89981543
Pemphigus 1626.83 9.32 16 475378 326848 89826205
Immune-mediated myositis 1501.75 9.32 541 474853 1880 90151173
Maternal exposure during pregnancy 1489.46 9.32 103 475291 359960 89793093
Rhabdomyolysis 1462.28 9.32 1565 473829 49691 90103362
Systemic lupus erythematosus 1355.71 9.32 156 475238 361740 89791313
Hand deformity 1349.04 9.32 46 475348 296316 89856737
Glossodynia 1296.71 9.32 104 475290 321675 89831378
Anti-cyclic citrullinated peptide antibody positive 1214.88 9.32 4 475390 236429 89916624
Acute kidney injury 1203.21 9.32 4055 471339 316332 89836721
Synovitis 1050.24 9.32 224 475170 329528 89823525
Duodenal ulcer perforation 1045.04 9.32 24 475370 221264 89931789
Pericarditis 1032.87 9.32 108 475286 270043 89883010
Wound 1017.15 9.32 181 475213 302799 89850254
Helicobacter infection 943.16 9.32 63 475331 226787 89926266
Folliculitis 918.31 9.32 35 475359 204318 89948735
Rheumatoid factor positive 870.27 9.32 5 475389 171645 89981408
Contraindicated product administered 861.16 9.32 302 475092 319837 89833216
Exposure during pregnancy 845.99 9.32 122 475272 238288 89914765
Cerebrovascular accident 794.60 9.32 1901 473493 121632 90031421
Infusion related reaction 757.62 9.32 644 474750 416136 89736917
Treatment failure 739.89 9.32 334 475060 303594 89849459
Rheumatic fever 733.16 9.32 14 475380 153107 89999946
Irritable bowel syndrome 731.69 9.32 108 475286 207340 89945713
Impaired healing 698.21 9.32 183 475211 234016 89919037
Myopathy 693.36 9.32 572 474822 12946 90140107
Muscle injury 684.42 9.32 67 475327 176587 89976466
Arthropathy 678.96 9.32 555 474839 365687 89787366
Myocardial infarction 659.19 9.32 1610 473784 104362 90048691
Therapeutic product effect decreased 638.99 9.32 329 475065 277242 89875811
Swelling 603.88 9.32 788 474606 418270 89734783
Blood creatine phosphokinase increased 601.70 9.32 815 474579 33208 90119845
Drug interaction 596.73 9.32 2949 472445 273504 89879549
Discomfort 592.63 9.32 352 475042 273983 89879070
Sleep disorder due to general medical condition, insomnia type 574.79 9.32 23 475371 128671 90024382
Swollen joint count increased 554.89 9.32 5 475389 111201 90041852
Alopecia 535.61 9.32 1122 474272 493949 89659104
Drug intolerance 534.93 9.32 956 474438 446635 89706418
Fall 522.86 9.32 4313 471081 477497 89675556
Stomatitis 517.99 9.32 409 474985 274289 89878764
Hypersensitivity 497.19 9.32 1024 474370 453653 89699400
Drug ineffective 496.51 9.32 4763 470631 1379535 88773518
Fibromyalgia 470.86 9.32 247 475147 206022 89947031
Product use issue 467.29 9.32 628 474766 329291 89823762
Abdominal discomfort 467.28 9.32 1142 474252 476186 89676867
Psoriatic arthropathy 460.17 9.32 317 475077 228018 89925035
Hepatic enzyme increased 448.61 9.32 751 474643 359985 89793068
Ill-defined disorder 439.15 9.32 210 475184 184681 89968372
Breast cancer stage III 415.75 9.32 5 475389 84442 90068611
Acute myocardial infarction 403.70 9.32 686 474708 34204 90118849
Injury 402.96 9.32 270 475124 197079 89955974
Off label use 399.63 9.32 3780 471614 1098472 89054581
Type 2 diabetes mellitus 399.21 9.32 290 475104 202954 89950099
Necrotising myositis 395.79 9.32 153 475241 678 90152375
Facet joint syndrome 395.37 9.32 32 475362 98357 90054696
Blister 394.94 9.32 453 474941 254545 89898508
Hypomagnesaemia 392.46 9.32 685 474709 34903 90118150
Lactic acidosis 383.57 9.32 830 474564 49633 90103420
Lip dry 381.37 9.32 42 475352 100913 90052140
Joint swelling 381.02 9.32 1358 474036 501942 89651111
Joint range of motion decreased 380.08 9.32 119 475275 135524 90017529
Live birth 367.88 9.32 10 475384 79097 90073956
Coronary artery disease 365.36 9.32 643 474751 32980 90120073
Deep vein thrombosis postoperative 349.45 9.32 4 475390 70805 90082248
Atrial fibrillation 346.72 9.32 1505 473889 132106 90020947
Intentional product use issue 340.51 9.32 381 475013 216511 89936542
Hyponatraemia 334.23 9.32 1488 473906 132050 90021003
Wound infection 332.85 9.32 75 475319 106327 90046726
Blood glucose increased 329.08 9.32 1174 474220 94072 90058981
Cholestasis 307.28 9.32 624 474770 35675 90117378
Mobility decreased 303.26 9.32 531 474863 250203 89902850
Grip strength decreased 298.25 9.32 61 475333 92515 90060538
Hypoglycaemia 295.58 9.32 922 474472 68926 90084127
Infection 290.76 9.32 952 474442 361142 89791911
Hyperkalaemia 287.44 9.32 871 474523 64093 90088960
Bursitis 271.54 9.32 178 475216 131476 90021577
Adjustment disorder with depressed mood 264.54 9.32 7 475387 56746 90096307
Liver injury 264.00 9.32 303 475091 170264 89982789
Anaemia 259.87 9.32 2912 472482 349890 89803163
Angina pectoris 256.27 9.32 607 474787 38553 90114500
C-reactive protein abnormal 255.17 9.32 178 475216 127251 90025802
Peripheral venous disease 254.88 9.32 63 475331 83858 90069195
Rheumatoid arthritis 254.87 9.32 1008 474386 361606 89791447
Syncope 253.70 9.32 1369 474025 131294 90021759
Dislocation of vertebra 253.30 9.32 9 475385 55959 90097094
Pregnancy 252.59 9.32 19 475375 62028 90091025
Lower respiratory tract infection 245.44 9.32 599 474795 250060 89902993
Autoimmune hepatitis 245.22 9.32 287 475107 10064 90142989
C-reactive protein increased 241.96 9.32 360 475034 181029 89972024
Mixed liver injury 240.96 9.32 246 475148 7377 90145676
Cardiac failure congestive 239.59 9.32 1090 474304 97604 90055449
Transient ischaemic attack 231.02 9.32 620 474774 42556 90110497
Bone erosion 228.48 9.32 12 475382 53009 90100044
Ischaemic stroke 223.05 9.32 410 474984 21756 90131297
Lupus vulgaris 220.32 9.32 3 475391 45056 90107997
X-ray abnormal 217.98 9.32 4 475390 45420 90107633
Hepatitis cholestatic 217.33 9.32 246 475148 8315 90144738
Onychomadesis 216.96 9.32 5 475389 45993 90107060
Musculoskeletal stiffness 214.92 9.32 814 474580 295718 89857335
Blepharospasm 214.72 9.32 21 475373 55424 90097629
Prescribed overdose 212.39 9.32 124 475270 97501 90055552
Liver function test abnormal 210.36 9.32 666 474728 50179 90102874
Renal failure 206.84 9.32 1285 474109 129722 90023331
Hemiplegia 203.36 9.32 330 475064 15830 90137223
Gastrointestinal haemorrhage 202.38 9.32 974 474420 89274 90063779
Blood cholesterol increased 202.10 9.32 499 474895 207513 89945540
Autoimmune myositis 200.77 9.32 74 475320 279 90152774
Muscular weakness 200.39 9.32 1806 473588 204860 89948193
Inflammation 199.27 9.32 397 474997 178195 89974858
Hypercholesterolaemia 195.37 9.32 146 475248 100746 90052307
Dysarthria 192.81 9.32 677 474717 53805 90099248
Lower limb fracture 189.21 9.32 105 475289 84908 90068145
Cardiac failure 188.79 9.32 1099 474295 108397 90044656
Rash 187.91 9.32 2992 472402 793108 89359945
Obesity 184.12 9.32 169 475225 105338 90047715
Diabetic ketoacidosis 182.65 9.32 399 474995 24008 90129045
Bradycardia 182.32 9.32 897 474497 82950 90070103
Dehydration 182.30 9.32 1687 473707 192760 89960293
Night sweats 180.16 9.32 247 475147 128519 90024534
Hip arthroplasty 177.16 9.32 89 475305 76119 90076934
Wheezing 176.75 9.32 647 474747 237433 89915620
Autoimmune disorder 176.35 9.32 91 475303 76653 90076400
Blood pressure increased 175.40 9.32 1692 473702 195525 89957528
Renal impairment 175.24 9.32 1048 474346 104373 90048680
Gastrointestinal disorder 174.91 9.32 722 474672 255965 89897088
Retinitis 174.68 9.32 6 475388 38452 90114601
Condition aggravated 174.67 9.32 2142 473252 593403 89559650
Melaena 170.61 9.32 484 474910 34313 90118740
Nail disorder 168.71 9.32 50 475344 59017 90094036
Polymyositis 164.25 9.32 116 475278 2063 90150990
Sinusitis 163.65 9.32 1090 474304 341998 89811055
Hepatic cytolysis 163.43 9.32 442 474952 30474 90122579
Pain 158.81 9.32 3998 471396 992343 89160710
Haematochezia 155.86 9.32 761 474633 70152 90082901
Macular degeneration 154.91 9.32 495 474899 37475 90115578
Neurologic neglect syndrome 153.46 9.32 210 475184 8637 90144416
Diabetes mellitus 151.87 9.32 709 474685 64166 90088887
Breast cancer stage II 149.15 9.32 9 475385 35325 90117728
Nasopharyngitis 148.79 9.32 1391 474003 405713 89747340
Weight increased 148.06 9.32 1439 473955 416488 89736565
Pulmonary fibrosis 147.60 9.32 209 475185 107294 90045759
Asthenia 147.42 9.32 3753 471641 529998 89623055
Urinary tract infection 146.00 9.32 2333 473061 303299 89849754
Carotid artery thrombosis 144.58 9.32 207 475187 8885 90144168
Cerebral haemorrhage 144.45 9.32 454 474940 34068 90118985
Angina unstable 143.14 9.32 182 475212 6961 90146092
Hemiparesis 142.96 9.32 429 474965 31390 90121663
Pancreatitis acute 140.54 9.32 429 474965 31686 90121367
Foetal exposure during pregnancy 139.07 9.32 28 475366 42947 90110106
Jaundice 138.24 9.32 430 474964 32087 90120966
Hypoaesthesia 137.70 9.32 1023 474371 313187 89839866
Hypokalaemia 137.52 9.32 1166 474228 129950 90023103
Road traffic accident 135.47 9.32 222 475172 107404 90045649
Lung disorder 134.52 9.32 374 475020 149509 90003544
Urticaria 133.82 9.32 1025 474369 311709 89841344
Cholestatic liver injury 133.80 9.32 130 475264 3667 90149386
Aphasia 132.97 9.32 510 474884 42302 90110751
Adverse event 132.69 9.32 259 475135 117159 90035894
Device expulsion 131.55 9.32 27 475367 40859 90112194
Adjustment disorder 131.10 9.32 204 475190 9438 90143615
Sciatica 129.60 9.32 207 475187 101175 90051878
Knee arthroplasty 129.49 9.32 147 475247 83035 90070018
Hepatocellular injury 128.76 9.32 389 475005 28569 90124484
Sleep disorder 128.12 9.32 568 474826 197462 89955591
Personality disorder 127.51 9.32 232 475162 12212 90140841
Coronary artery occlusion 126.23 9.32 188 475206 8366 90144687
Product use in unapproved indication 126.21 9.32 1141 474253 335095 89817958
Prescribed underdose 124.10 9.32 126 475268 74893 90078160
Low density lipoprotein increased 124.08 9.32 181 475213 7904 90145149
Chronic obstructive pulmonary disease 123.99 9.32 736 474658 73093 90079960
Drug tolerance decreased 122.26 9.32 13 475381 32117 90120936
Abortion spontaneous 121.39 9.32 66 475328 53990 90099063
Polymyalgia rheumatica 119.57 9.32 139 475255 4838 90148215
Diabetes mellitus inadequate control 119.41 9.32 287 475107 18397 90134656
Pemphigoid 117.23 9.32 187 475207 8839 90144214
Myelosuppression 116.65 9.32 68 475326 53523 90099530
Glycosylated haemoglobin increased 115.98 9.32 254 475140 15308 90137745
Dry mouth 115.43 9.32 534 474860 183525 89969528
Motor dysfunction 115.05 9.32 288 475106 18942 90134111
Rectal haemorrhage 114.92 9.32 786 474608 81958 90071095
Palpitations 114.67 9.32 1159 474235 135569 90017484
Eating disorder 114.53 9.32 366 475028 27707 90125346
Hypertensive emergency 114.07 9.32 94 475300 2123 90150930
Red blood cell sedimentation rate increased 112.96 9.32 161 475233 82434 90070619
Epilepsy 112.66 9.32 160 475234 82046 90071007
Dysphagia 112.25 9.32 988 474406 111290 90041763
Dyspnoea 111.49 9.32 5667 469727 875288 89277765
Muscle necrosis 111.38 9.32 64 475330 780 90152273
Gait inability 111.29 9.32 394 475000 146062 90006991
Migraine 110.36 9.32 568 474826 189824 89963229
Normal newborn 108.43 9.32 3 475391 23359 90129694
Myocardial ischaemia 108.14 9.32 230 475164 13584 90139469
International normalised ratio increased 107.74 9.32 513 474881 46803 90106250
Cardiac disorder 107.37 9.32 585 474809 56287 90096766
Chronic kidney disease 106.99 9.32 534 474860 49657 90103396
Cough 106.37 9.32 2610 472784 366352 89786701
Sensory loss 106.36 9.32 269 475125 17806 90135247
Coeliac disease 105.34 9.32 51 475343 44559 90108494
Hepatitis acute 105.31 9.32 198 475196 10689 90142364
Premature delivery 105.03 9.32 36 475358 38726 90114327
Dizziness 103.80 9.32 3923 471471 585361 89567692
Muscle spasms 103.58 9.32 1877 473517 250006 89903047
Drug abuse 102.57 9.32 171 475223 82176 90070877
Product label confusion 102.27 9.32 4 475390 22846 90130207
Onychomycosis 100.78 9.32 35 475359 37341 90115712
Blood alkaline phosphatase increased 100.70 9.32 509 474885 47570 90105483
Labelled drug-drug interaction medication error 99.73 9.32 230 475164 14352 90138701
General physical health deterioration 98.77 9.32 1291 474103 353824 89799229
Incorrect route of product administration 98.33 9.32 73 475321 50553 90102500
Affect lability 98.25 9.32 261 475133 17802 90135251
Chromaturia 98.11 9.32 271 475123 18916 90134137
Haemorrhage intracranial 98.08 9.32 234 475160 14928 90138125
Maternal exposure timing unspecified 97.15 9.32 5 475389 22478 90130575
Back pain 96.65 9.32 2261 473133 314914 89838139
Hepatic steatosis 96.39 9.32 417 474977 36528 90116525
Acute coronary syndrome 95.22 9.32 189 475205 10624 90142429
Arterial occlusive disease 94.88 9.32 205 475189 12241 90140812
Osteoarthritis 94.66 9.32 619 474775 195111 89957942
Coronary artery stenosis 94.38 9.32 127 475267 5139 90147914
Hypocalcaemia 94.04 9.32 456 474938 41912 90111141
Hypotension 93.51 9.32 2301 473093 323096 89829957
Completed suicide 92.64 9.32 418 474976 144640 90008413
Coordination abnormal 92.25 9.32 284 475110 21072 90131981
Blood triglycerides increased 91.86 9.32 215 475179 13546 90139507
Dysuria 90.30 9.32 428 474966 38973 90114080
Hyperglycaemia 88.73 9.32 513 474881 50457 90102596
Multi-organ disorder 88.38 9.32 81 475313 2119 90150934
Back injury 88.28 9.32 69 475325 46553 90106500
Eosinophilia 87.86 9.32 339 475055 28194 90124859
Atrioventricular block 87.36 9.32 162 475232 8653 90144400
Ear infection 86.80 9.32 145 475249 69630 90083423
Oedema 86.78 9.32 654 474740 199641 89953412
Urinary tract discomfort 86.55 9.32 56 475338 856 90152197
Haematoma 85.76 9.32 419 474975 38629 90114424
Chest pain 85.55 9.32 2239 473155 317406 89835647
Contusion 84.28 9.32 876 474518 250340 89902713
Laryngitis 84.22 9.32 85 475309 50668 90102385
Lupus-like syndrome 83.13 9.32 80 475314 48766 90104287
Haematemesis 82.93 9.32 374 475020 33352 90119701
Seronegative arthritis 82.27 9.32 3 475391 18231 90134822
Nausea 82.19 9.32 6823 468571 1103493 89049560
Weight decreased 82.05 9.32 2590 472804 377320 89775733
Skin haemorrhage 81.16 9.32 272 475122 21108 90131945
Therapeutic drug monitoring analysis not performed 80.47 9.32 62 475332 1267 90151786
Thyroid disorder 80.09 9.32 240 475154 17545 90135508
Chest discomfort 79.61 9.32 1091 474303 137274 90015779
Swollen tongue 79.00 9.32 461 474933 45495 90107558
Lip swelling 78.24 9.32 405 474989 38205 90114848
Diarrhoea 78.04 9.32 5824 469570 933366 89219687
Taste disorder 77.39 9.32 127 475267 61419 90091634
Sinus disorder 77.35 9.32 372 475022 34075 90118978
Joint dislocation 77.07 9.32 72 475322 44510 90108543
Atrioventricular block complete 76.40 9.32 163 475231 9648 90143405
Euglycaemic diabetic ketoacidosis 75.82 9.32 125 475269 6076 90146977
Blood creatinine increased 75.42 9.32 839 474555 100547 90052506
Pyrexia 75.10 9.32 2771 472623 657714 89495339
Carotid artery stenosis 74.13 9.32 114 475280 5220 90147833
Gamma-glutamyltransferase increased 74.08 9.32 394 475000 37558 90115495
Cerebral infarction 73.89 9.32 306 475088 26290 90126763
Alveolar osteitis 73.66 9.32 56 475338 1121 90151932
Exostosis 73.22 9.32 103 475291 53031 90100022
Hypoacusis 73.15 9.32 315 475079 27535 90125518
Pulmonary oedema 73.14 9.32 567 474827 61513 90091540
Injection site reaction 73.14 9.32 243 475151 91837 90061216
Skin exfoliation 72.79 9.32 607 474787 67306 90085747
Dementia 72.25 9.32 282 475112 23579 90129474
Intentional overdose 72.23 9.32 251 475143 93583 90059470
Caesarean section 72.02 9.32 7 475387 18570 90134483
Febrile neutropenia 71.97 9.32 510 474884 157839 89995214
Upper gastrointestinal haemorrhage 71.58 9.32 274 475120 22702 90130351
Subdural haematoma 71.57 9.32 221 475173 16424 90136629
Hallucination 71.48 9.32 591 474803 65368 90087685
Cataract 71.32 9.32 633 474761 71459 90081594
Mitral valve incompetence 70.50 9.32 269 475125 22255 90130798
Haemoglobin decreased 70.49 9.32 1218 474176 160738 89992315
Head injury 70.17 9.32 337 475057 30851 90122202
Epistaxis 68.69 9.32 716 474678 84409 90068644
Arteriosclerosis 68.59 9.32 166 475228 10687 90142366
Disorientation 68.51 9.32 431 474963 43683 90109370
Blood urea increased 67.97 9.32 328 475066 30085 90122968
Carotid arteriosclerosis 66.80 9.32 54 475340 1186 90151867
Hyperlipidaemia 66.31 9.32 267 475127 22649 90130404
Vascular stent stenosis 65.37 9.32 42 475352 634 90152419
Metabolic acidosis 64.75 9.32 507 474887 55169 90097884
Blood glucose decreased 64.64 9.32 269 475125 23160 90129893
Product prescribing error 63.73 9.32 320 475074 29825 90123228
Delirium 63.50 9.32 306 475088 104053 90049000
Electrocardiogram QT prolonged 63.05 9.32 619 474775 71837 90081216
Malignant neoplasm progression 62.93 9.32 317 475077 106553 90046500
Dermatitis atopic 62.82 9.32 267 475127 23205 90129848
Angioedema 62.31 9.32 566 474828 64310 90088743
Blood loss anaemia 61.86 9.32 153 475241 9987 90143066
Presyncope 61.27 9.32 329 475065 31476 90121577
Disability 61.26 9.32 74 475320 40671 90112382
Hepatic cirrhosis 61.17 9.32 152 475242 63101 90089952
Inappropriate antidiuretic hormone secretion 61.09 9.32 233 475161 19272 90133781
Temperature regulation disorder 60.68 9.32 4 475390 14575 90138478
Constipation 60.34 9.32 1911 473483 278484 89874569
Premature baby 60.23 9.32 28 475366 25049 90128004
Muscle atrophy 60.22 9.32 135 475259 8266 90144787
Blood cholesterol abnormal 60.08 9.32 75 475319 2815 90150238
Pollakiuria 59.95 9.32 336 475058 32669 90120384
Tunnel vision 59.49 9.32 58 475336 1643 90151410
Eye haemorrhage 59.37 9.32 151 475243 10029 90143024
Large intestine polyp 58.72 9.32 143 475251 9243 90143810
Intentional self-injury 58.66 9.32 41 475353 29293 90123760
Immunodeficiency 58.39 9.32 85 475309 43149 90109904
Body height decreased 58.37 9.32 166 475228 11783 90141270
Dyspnoea exertional 58.31 9.32 608 474786 71680 90081373
Balance disorder 58.10 9.32 771 474623 96309 90056744
Flatulence 58.04 9.32 394 475000 40973 90112080
Feeling abnormal 57.78 9.32 1214 474180 166021 89987032
Joint destruction 57.27 9.32 3 475391 13284 90139769
Haematuria 57.18 9.32 346 475048 34591 90118462
Ear congestion 57.15 9.32 80 475314 3362 90149691
Hepatic function abnormal 56.89 9.32 427 474967 45861 90107192
Toxicity to various agents 56.71 9.32 1116 474278 286730 89866323
Joint injury 56.36 9.32 328 475066 32336 90120717
Glomerular filtration rate decreased 56.14 9.32 206 475188 16726 90136327
Blood pressure systolic increased 55.51 9.32 508 474886 57837 90095216
Product dose omission issue 55.38 9.32 1959 473435 289728 89863325
Pain in extremity 55.27 9.32 2891 472503 447638 89705415
Orthostatic hypotension 54.93 9.32 392 475002 41435 90111618
Vertigo 54.82 9.32 584 474810 69227 90083826
Infusion site reaction 54.58 9.32 16 475378 19023 90134030
Acute respiratory failure 54.51 9.32 399 474995 42519 90110534
Pustular psoriasis 54.29 9.32 15 475379 18541 90134512
Labile blood pressure 53.87 9.32 58 475336 1852 90151201
Gastrointestinal toxicity 53.74 9.32 139 475255 9328 90143725
Vision blurred 53.72 9.32 845 474549 109448 90043605
Blood iron decreased 53.37 9.32 211 475183 17748 90135305
Alanine aminotransferase increased 53.31 9.32 895 474499 117443 90035610
Hypertensive crisis 52.89 9.32 209 475185 17575 90135478
Influenza like illness 52.81 9.32 651 474743 79960 90073093
Dysgeusia 52.76 9.32 463 474931 52097 90100956
Lethargy 52.32 9.32 534 474860 62605 90090448
Peripheral arterial occlusive disease 52.31 9.32 90 475304 4531 90148522
Product monitoring error 52.09 9.32 89 475305 4455 90148598
Dyslipidaemia 51.92 9.32 143 475251 9964 90143089
Therapy non-responder 51.61 9.32 463 474931 136241 90016812
Drug tolerance 51.46 9.32 15 475379 17901 90135152
Faeces discoloured 51.35 9.32 235 475159 21085 90131968
Myoglobin blood increased 50.72 9.32 51 475343 1501 90151552
High density lipoprotein decreased 50.69 9.32 66 475328 2585 90150468
Bladder pain 50.57 9.32 67 475327 2670 90150383
Swelling face 50.31 9.32 650 474744 80702 90072351
Adverse drug reaction 50.07 9.32 382 475012 116319 90036734
Foetal death 49.99 9.32 23 475371 20700 90132353
Gangrene 49.93 9.32 165 475229 12711 90140342
Product substitution issue 49.87 9.32 207 475187 17801 90135252
Movement disorder 49.81 9.32 291 475103 28728 90124325
Walking aid user 49.75 9.32 68 475326 35438 90117615
Transaminases increased 49.68 9.32 350 475044 36842 90116211
Hepatitis toxic 49.52 9.32 78 475316 3647 90149406
Red blood cell sedimentation rate abnormal 49.51 9.32 33 475361 24171 90128882
Drug resistance 49.38 9.32 52 475342 30397 90122656
Foot deformity 49.05 9.32 155 475239 59496 90093557
Subarachnoid haemorrhage 48.95 9.32 205 475189 17699 90135354
Aspartate aminotransferase increased 48.76 9.32 785 474609 102152 90050901
Ischaemic cardiomyopathy 48.33 9.32 64 475330 2549 90150504
Gastric ulcer 48.25 9.32 277 475117 27171 90125882
Dry skin 48.04 9.32 688 474706 87385 90065668
Therapeutic response decreased 47.93 9.32 275 475119 89454 90063599
Adverse reaction 47.90 9.32 51 475343 29661 90123392
Panniculitis 47.66 9.32 9 475385 14449 90138604
Subacute cutaneous lupus erythematosus 47.61 9.32 75 475319 3507 90149546
Dysstasia 47.48 9.32 258 475136 24794 90128259
Animal scratch 47.16 9.32 53 475341 1777 90151276
Finger deformity 47.11 9.32 62 475332 32835 90120218
Malaise 46.70 9.32 3623 471771 582363 89570690
Drug-induced liver injury 46.30 9.32 698 474696 89620 90063433
Renal disorder 45.83 9.32 348 475046 37511 90115542
Intestinal haemorrhage 45.68 9.32 83 475311 4364 90148689
Blood sodium decreased 45.53 9.32 274 475120 27339 90125714
Incorrect dosage administered 45.31 9.32 65 475329 2795 90150258
Musculoskeletal chest pain 45.29 9.32 245 475149 23505 90129548
Cystitis 45.09 9.32 542 474852 66176 90086877
Oedema peripheral 45.01 9.32 1716 473678 256199 89896854
Ketoacidosis 44.77 9.32 94 475300 5501 90147552
Tubulointerstitial nephritis 44.71 9.32 256 475138 25087 90127966
Arrhythmia 44.64 9.32 377 475017 41955 90111098
Embolic stroke 44.39 9.32 78 475316 3994 90149059
Duodenal ulcer 44.06 9.32 130 475264 9422 90143631
Hypovolaemia 43.56 9.32 154 475240 12277 90140776
Product quality issue 43.52 9.32 241 475153 79084 90073969
Paraesthesia oral 43.50 9.32 300 475094 31359 90121694
Pre-eclampsia 43.26 9.32 4 475390 11044 90142009
Rales 43.10 9.32 181 475213 15646 90137407
Drug hypersensitivity 42.82 9.32 2901 472493 460708 89692345
Abnormal loss of weight 42.73 9.32 104 475290 6719 90146334
Cerebral haematoma 42.73 9.32 79 475315 4210 90148843
Angiopathy 42.62 9.32 91 475303 5389 90147664
Cytomegalovirus infection 42.50 9.32 46 475348 26556 90126497
Respiratory disorder 42.43 9.32 185 475209 64631 90088422
Anuria 42.35 9.32 172 475222 14646 90138407
Atrioventricular block first degree 42.32 9.32 119 475275 8392 90144661
Pulmonary toxicity 42.27 9.32 145 475249 11386 90141667
Myositis 42.09 9.32 243 475151 23885 90129168
Loss of consciousness 41.82 9.32 997 474397 139241 90013812
Maternal exposure before pregnancy 41.50 9.32 5 475389 11208 90141845
Electrolyte imbalance 41.33 9.32 239 475155 23506 90129547
Electrocardiogram abnormal 40.86 9.32 133 475261 10165 90142888
Drug ineffective for unapproved indication 40.78 9.32 195 475199 66449 90086604
Food allergy 40.77 9.32 44 475350 25434 90127619
Premature labour 40.69 9.32 10 475384 13366 90139687
Muscle disorder 40.34 9.32 89 475305 5390 90147663
Suicide attempt 40.32 9.32 231 475163 75168 90077885
Cardiac failure acute 40.28 9.32 146 475248 11783 90141270
Myopathy toxic 40.17 9.32 30 475364 584 90152469
Stent placement 40.10 9.32 76 475318 4127 90148926
Drug reaction with eosinophilia and systemic symptoms 40.02 9.32 371 475023 42387 90110666
Gastrointestinal procedural complication 39.47 9.32 27 475367 455 90152598
Diabetic metabolic decompensation 39.43 9.32 50 475344 1907 90151146
Depressed mood 39.37 9.32 420 474974 49802 90103251
Ulcer haemorrhage 39.36 9.32 48 475346 26273 90126780
Muscle rupture 39.32 9.32 64 475330 3077 90149976
Polyuria 39.24 9.32 129 475265 9911 90143142
Pulmonary renal syndrome 39.21 9.32 29 475365 556 90152497
Rectal polyp 39.02 9.32 38 475356 1075 90151978
Carotid artery occlusion 39.01 9.32 96 475298 6246 90146807
Proctitis 38.86 9.32 171 475223 15088 90137965
Dermatomyositis 38.63 9.32 66 475328 3304 90149749
Gestational diabetes 38.48 9.32 5 475389 10577 90142476
Calculus urinary 38.43 9.32 46 475348 1652 90151401
Potentiating drug interaction 38.38 9.32 89 475305 5573 90147480
Atrial flutter 38.32 9.32 134 475260 10624 90142429
Myocardial necrosis marker increased 38.23 9.32 52 475342 2126 90150927
Ocular myasthenia 38.20 9.32 19 475375 169 90152884
Blood potassium increased 38.19 9.32 212 475182 20537 90132516
Retinal artery occlusion 38.03 9.32 53 475341 2218 90150835
Spur cell anaemia 37.94 9.32 14 475380 53 90153000
Diabetic retinopathy 37.90 9.32 58 475336 2644 90150409
Sinus bradycardia 37.29 9.32 182 475212 16770 90136283
Heart rate increased 37.19 9.32 814 474580 112088 90040965
Diplopia 37.06 9.32 268 475126 28446 90124607
Infective pulmonary exacerbation of cystic fibrosis 37.03 9.32 5 475389 10274 90142779
Aortic stenosis 36.97 9.32 94 475300 6242 90146811
Urinary tract obstruction 36.94 9.32 52 475342 2197 90150856
Wound complication 36.93 9.32 79 475315 4684 90148369
Rhinorrhoea 36.91 9.32 660 474734 87656 90065397
Device dislocation 36.81 9.32 68 475326 31414 90121639
Overweight 36.69 9.32 90 475304 5844 90147209
Flank pain 36.46 9.32 198 475196 19024 90134029
Vaginal flatulence 36.36 9.32 147 475247 12491 90140562
Nasal congestion 36.15 9.32 627 474767 82787 90070266
Chronic sinusitis 35.99 9.32 231 475163 23571 90129482
Limb injury 35.58 9.32 285 475109 31223 90121830
Peripheral artery stenosis 35.53 9.32 28 475366 592 90152461
Blood pressure decreased 35.41 9.32 571 474823 74324 90078729
Blood cholesterol decreased 35.26 9.32 47 475347 1884 90151169
Cholelithiasis 35.24 9.32 426 474968 52080 90100973
Cerebral ischaemia 35.18 9.32 100 475294 7096 90145957
Nasal obstruction 35.14 9.32 55 475339 2557 90150496
Autoantibody positive 35.02 9.32 14 475380 69 90152984
Somnolence 35.02 9.32 1385 474009 207699 89945354
Sinus congestion 34.85 9.32 255 475139 27169 90125884
COVID-19 34.79 9.32 1145 474249 167698 89985355
Hypophagia 34.74 9.32 314 475080 35623 90117430
Urinary retention 34.58 9.32 326 475068 37418 90115635
Ecchymosis 34.40 9.32 142 475252 12181 90140872
Urinary incontinence 34.19 9.32 324 475070 37242 90115811
Blood creatine phosphokinase MB increased 34.03 9.32 37 475357 1195 90151858
Parkinsonism 33.85 9.32 155 475239 13910 90139143
Neutropenia 33.84 9.32 909 474485 223995 89929058
Sneezing 33.63 9.32 270 475124 29599 90123454
Nightmare 33.57 9.32 212 475182 21513 90131540
Radiculopathy 33.35 9.32 188 475206 18317 90134736
Wound secretion 33.35 9.32 78 475316 4912 90148141
Mouth swelling 33.04 9.32 84 475310 5578 90147475
Anti-neutrophil cytoplasmic antibody positive vasculitis 33.02 9.32 68 475326 3925 90149128
Interstitial lung disease 33 9.32 574 474820 75831 90077222
Arteriosclerosis coronary artery 32.82 9.32 118 475276 9485 90143568
Hypokinesia 32.74 9.32 166 475228 15531 90137522
Drug use disorder 32.73 9.32 3 475391 8340 90144713
Disease progression 32.72 9.32 601 474793 156014 89997039
Ventricular tachycardia 32.70 9.32 232 475162 24476 90128577
Procedural pain 32.52 9.32 292 475102 33068 90119985
Haemorrhagic transformation stroke 32.42 9.32 37 475357 1262 90151791
Polyp 32.41 9.32 101 475293 7543 90145510
Aldolase increased 32.20 9.32 16 475378 142 90152911
Rheumatoid nodule 32.08 9.32 35 475359 20131 90132922
Feeling cold 31.87 9.32 250 475144 27215 90125838
Eructation 31.65 9.32 127 475267 10755 90142298
Hepatorenal syndrome 31.65 9.32 46 475348 2002 90151051
Myasthenia gravis 31.59 9.32 93 475301 6732 90146321
Leukopenia 31.41 9.32 357 475037 100353 90052700
Polyarthritis 31.29 9.32 30 475364 18320 90134733
Neoplasm malignant 31.22 9.32 293 475101 33587 90119466
Acidosis 31.13 9.32 141 475253 12595 90140458
Gastritis 30.80 9.32 345 475049 41408 90111645
Underdose 30.79 9.32 162 475232 53855 90099198
Low density lipoprotein abnormal 30.78 9.32 20 475374 308 90152745
Therapeutic product effect incomplete 30.67 9.32 778 474616 193118 89959935
Speech disorder 30.66 9.32 370 475024 45215 90107838
Colitis ischaemic 30.42 9.32 137 475257 12209 90140844
Eye pain 30.36 9.32 360 475034 43808 90109245
Hyperlactacidaemia 30.25 9.32 67 475327 4069 90148984
Facial paralysis 30.13 9.32 161 475233 15373 90137680
Cell death 30.09 9.32 56 475338 2999 90150054
General symptom 30.00 9.32 20 475374 14648 90138405
Multiple-drug resistance 29.96 9.32 3 475391 7773 90145280
Diabetic nephropathy 29.83 9.32 41 475353 1693 90151360
Eye irritation 29.42 9.32 290 475104 33688 90119365
Peripheral sensory neuropathy 29.38 9.32 111 475283 9139 90143914
Colitis 29.33 9.32 523 474871 69419 90083634
Haemorrhoids 29.32 9.32 240 475154 26462 90126591
Diabetic ketosis 29.31 9.32 24 475370 537 90152516
Hypervolaemia 29.05 9.32 281 475113 32476 90120577
Mucosal inflammation 28.98 9.32 180 475214 57445 90095608
Abortion induced 28.98 9.32 13 475381 11875 90141178
Diverticulum 28.79 9.32 133 475261 11980 90141073
Ligament sprain 28.79 9.32 152 475242 14447 90138606
Haematotoxicity 28.59 9.32 15 475379 12520 90140533
Cardiac murmur 28.40 9.32 178 475216 18016 90135037
Gastric ulcer haemorrhage 28.13 9.32 76 475318 5235 90147818
Cardiac failure chronic 28.13 9.32 79 475315 5567 90147486
Asthma 28.08 9.32 1013 474381 241147 89911906
Skin laceration 28.05 9.32 233 475161 25802 90127251
Blood magnesium decreased 28.00 9.32 159 475235 15534 90137519
Haemophagocytic lymphohistiocytosis 27.87 9.32 24 475370 15435 90137618
Diverticulum intestinal haemorrhagic 27.86 9.32 40 475354 1721 90151332
Abnormal dreams 27.80 9.32 125 475269 11132 90141921
Cytomegalovirus infection reactivation 27.62 9.32 4 475390 7796 90145257
Coronary artery thrombosis 27.61 9.32 32 475362 1110 90151943
Liver function test increased 27.57 9.32 298 475096 84557 90068496
Oestradiol decreased 27.52 9.32 13 475381 102 90152951
Ageusia 27.45 9.32 161 475233 15915 90137138
Tremor 27.39 9.32 1022 474372 152151 90000902
Blood parathyroid hormone decreased 27.30 9.32 15 475379 12201 90140852
Torsade de pointes 27.20 9.32 154 475240 15028 90138025
Oligohydramnios 27.18 9.32 3 475391 7198 90145855
Traumatic coma 26.47 9.32 11 475383 61 90152992
Uterine perforation 26.45 9.32 4 475390 7550 90145503
Rash vesicular 26.36 9.32 34 475360 18163 90134890
Blood urine present 26.32 9.32 168 475226 17110 90135943
Renal tubular necrosis 26.32 9.32 148 475246 14407 90138646
Tension headache 26.29 9.32 93 475301 7416 90145637
Paranasal sinus discomfort 26.28 9.32 82 475312 6128 90146925
Pancreatitis haemorrhagic 26.28 9.32 24 475370 625 90152428
Cardiac valve disease 26.25 9.32 68 475326 4567 90148486
Atrial tachycardia 26.19 9.32 80 475314 5910 90147143
Urine output decreased 26.09 9.32 133 475261 12470 90140583
Hepatic ischaemia 26.03 9.32 26 475368 759 90152294
Lichen planopilaris 25.95 9.32 15 475379 185 90152868
Primary biliary cholangitis 25.95 9.32 34 475360 1340 90151713
Tinnitus 25.65 9.32 342 475052 42760 90110293
Muscle fatigue 25.62 9.32 51 475343 2873 90150180
Coronary artery bypass 25.61 9.32 45 475349 2304 90150749
Cardiac operation 25.60 9.32 61 475333 3888 90149165
Troponin increased 25.32 9.32 137 475257 13144 90139909
Peripheral swelling 25.31 9.32 1845 473549 411261 89741792
Gait disturbance 25.25 9.32 1637 473757 258859 89894194
Diverticulum intestinal 25.25 9.32 105 475289 9037 90144016
Hiatus hernia 25.24 9.32 223 475171 25138 90127915
Respiratory tract congestion 25.24 9.32 237 475157 27173 90125880
Pericardial effusion 25.22 9.32 300 475094 36533 90116520
Blood creatine increased 25.01 9.32 87 475307 6880 90146173
Systemic infection 24.96 9.32 68 475326 4707 90148346
Tongue oedema 24.94 9.32 74 475320 5380 90147673
Foetal growth restriction 24.92 9.32 9 475385 9371 90143682
Ventricular hypertrophy 24.88 9.32 55 475339 3336 90149717
Choluria 24.82 9.32 16 475378 243 90152810
Carbuncle 24.78 9.32 34 475360 1402 90151651
Influenza 24.61 9.32 928 474466 138336 90014717
Post viral fatigue syndrome 24.59 9.32 16 475378 247 90152806
Heart rate decreased 24.58 9.32 406 474988 53099 90099954
Therapy partial responder 24.56 9.32 49 475345 21994 90131059
Hypochloraemia 24.51 9.32 47 475347 2575 90150478
Demyelination 24.48 9.32 96 475298 8044 90145009
Spondylitis 24.38 9.32 23 475371 14155 90138898
Breast cancer stage I 24.29 9.32 10 475384 9614 90143439
Stress cardiomyopathy 24.28 9.32 136 475258 13219 90139834
Nasal oedema 24.21 9.32 3 475391 6581 90146472
Decreased appetite 24.11 9.32 2291 473103 374249 89778804
Hypovolaemic shock 24.10 9.32 87 475307 7007 90146046
Renal injury 24.00 9.32 112 475282 10131 90142922
Carotid artery disease 23.85 9.32 36 475358 1621 90151432
Creatinine renal clearance decreased 23.76 9.32 39 475355 18860 90134193
Respiratory depression 23.72 9.32 28 475366 15547 90137506
Sinus pain 23.59 9.32 72 475322 5317 90147736
Sinus node dysfunction 23.40 9.32 72 475322 5340 90147713
Coronary artery restenosis 23.34 9.32 17 475377 318 90152735
Neuroglycopenia 23.28 9.32 29 475365 1086 90151967
Cardiogenic shock 23.25 9.32 213 475181 24255 90128798
Nocturia 23.20 9.32 111 475283 10144 90142909
Aspergillus infection 23.17 9.32 14 475380 10809 90142244
Sickle cell anaemia with crisis 23.10 9.32 5 475389 7292 90145761
Arthralgia 23.09 9.32 3659 471735 774863 89378190
Graft versus host disease 23.06 9.32 7 475387 8137 90144916
Vaginal discharge 23.05 9.32 178 475216 19286 90133767
Hip fracture 22.91 9.32 270 475124 32807 90120246
Acute myeloid leukaemia 22.90 9.32 46 475348 20594 90132459
Antimitochondrial antibody positive 22.88 9.32 10 475384 64 90152989
Wrong patient received product 22.85 9.32 54 475340 3423 90149630
Haemorrhage 22.79 9.32 500 474894 68869 90084184
Reversible cerebral vasoconstriction syndrome 22.79 9.32 60 475334 4070 90148983
Musculoskeletal pain 22.76 9.32 704 474690 170547 89982506
Epstein-Barr virus infection 22.69 9.32 13 475381 10331 90142722
Microcytic anaemia 22.65 9.32 57 475337 3761 90149292
Colitis microscopic 22.57 9.32 117 475277 11042 90142011
Glucose urine present 22.52 9.32 26 475368 898 90152155
Muscle relaxant therapy 22.51 9.32 13 475381 160 90152893
Cervix neoplasm 22.33 9.32 14 475380 202 90152851
Cardiac pacemaker insertion 22.29 9.32 62 475332 4345 90148708
Blood potassium decreased 22.23 9.32 363 475031 47364 90105689
Acquired plagiocephaly 22.17 9.32 7 475387 14 90153039
Fibromatosis colli of infancy 22.17 9.32 7 475387 14 90153039
Lower gastrointestinal haemorrhage 22.15 9.32 99 475295 8793 90144260
Spinal epidural haematoma 22.14 9.32 31 475363 1303 90151750
Amyloid related imaging abnormality-oedema/effusion 22.07 9.32 26 475368 918 90152135
Intra-abdominal haematoma 22 9.32 40 475354 2104 90150949
Faeces pale 21.92 9.32 38 475356 1925 90151128
Diabetic neuropathy 21.81 9.32 63 475331 4511 90148542
Retroperitoneal haematoma 21.81 9.32 52 475342 3316 90149737
Arteriovenous fistula occlusion 21.79 9.32 17 475377 354 90152699
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits 21.78 9.32 22 475372 651 90152402
Waist circumference increased 21.78 9.32 26 475368 931 90152122
Hepatitis 21.72 9.32 505 474889 70234 90082819
Mitral valve stenosis 21.70 9.32 31 475363 1328 90151725
Eczema 21.69 9.32 394 475000 52476 90100577
Dialysis 21.69 9.32 117 475277 11212 90141841
Troponin T increased 21.59 9.32 34 475360 1589 90151464
Pallor 21.55 9.32 274 475120 33891 90119162
Purpura 21.48 9.32 142 475252 14636 90138417
Haemorrhagic cyst 21.42 9.32 15 475379 263 90152790
Lecithin-cholesterol acyltransferase deficiency 21.41 9.32 6 475388 6 90153047
Cytokine release syndrome 21.40 9.32 75 475319 27898 90125155
International normalised ratio abnormal 21.36 9.32 56 475338 3789 90149264
Metastases to central nervous system 21.31 9.32 37 475357 17505 90135548
Hypocholesterolaemia 21.29 9.32 4 475390 6445 90146608
Eye injury 21.26 9.32 16 475378 11004 90142049
Pseudoporphyria 21.23 9.32 15 475379 267 90152786
Acute pulmonary oedema 21.18 9.32 103 475291 9477 90143576
Photosensitivity reaction 21.17 9.32 163 475231 17644 90135409
Blood parathyroid hormone increased 21.11 9.32 52 475342 3385 90149668
Dilatation intrahepatic duct acquired 21.10 9.32 23 475371 745 90152308
Mammogram abnormal 21.06 9.32 24 475370 817 90152236
Neutrophil count decreased 20.98 9.32 257 475137 71275 90081778
Supraventricular extrasystoles 20.95 9.32 68 475326 5189 90147864
Alanine aminotransferase 20.79 9.32 10 475384 82 90152971
Hyperhidrosis 20.78 9.32 894 474500 135411 90017642
Urine abnormality 20.69 9.32 88 475306 7649 90145404
Calcium deficiency 20.69 9.32 30 475364 1303 90151750
Noninfective gingivitis 20.63 9.32 39 475355 2114 90150939
Musculoskeletal discomfort 20.59 9.32 184 475210 20807 90132246
Prolonged expiration 20.55 9.32 29 475365 1228 90151825
Shock haemorrhagic 20.50 9.32 122 475272 12123 90140930
Neurotoxicity 20.43 9.32 52 475342 21415 90131638
Skin necrosis 20.34 9.32 36 475358 16905 90136148
Myoglobinuria 20.30 9.32 17 475377 393 90152660
Loose tooth 20.27 9.32 54 475340 3689 90149364
Blood glucose abnormal 20.23 9.32 101 475293 9391 90143662
Hypertensive cardiomyopathy 20.22 9.32 15 475379 289 90152764
Nervousness 20.17 9.32 270 475124 33786 90119267
Muscle spasticity 20.09 9.32 278 475116 35044 90118009
Periorbital haematoma 20.07 9.32 23 475371 788 90152265
Lipoprotein (a) increased 20.04 9.32 9 475385 62 90152991
Arterial stenosis 20.02 9.32 22 475372 719 90152334
Unintentional medical device removal 19.98 9.32 6 475388 7024 90146029
Intermittent claudication 19.98 9.32 35 475359 1788 90151265
Lung neoplasm malignant 19.97 9.32 205 475189 24068 90128985
Muscle oedema 19.96 9.32 7 475387 22 90153031
Hallucination, visual 19.95 9.32 197 475197 22895 90130158
Vascular device infection 19.85 9.32 20 475374 11932 90141121
Anticoagulation drug level abnormal 19.81 9.32 11 475383 125 90152928
Hallucination, gustatory 19.80 9.32 9 475385 64 90152989
Burning sensation 19.79 9.32 454 474940 62998 90090055
Rash papular 19.75 9.32 178 475216 20177 90132876
Left ventricular hypertrophy 19.74 9.32 74 475320 6070 90146983
Cystostomy 19.68 9.32 9 475385 65 90152988
Incision site haemorrhage 19.63 9.32 20 475374 598 90152455
Heart sounds 19.61 9.32 27 475367 1117 90151936
Scleroedema 19.51 9.32 11 475383 129 90152924
Peripheral vascular disorder 19.47 9.32 76 475318 6355 90146698
Circulatory collapse 19.39 9.32 208 475186 24696 90128357
Throat clearing 19.33 9.32 54 475340 3793 90149260
Product taste abnormal 19.30 9.32 41 475353 2419 90150634
Female genital tract fistula 19.30 9.32 160 475234 17708 90135345
Neurosensory hypoacusis 19.27 9.32 13 475381 214 90152839
Left atrial enlargement 19.22 9.32 21 475373 682 90152371
Obstructive airways disorder 19.19 9.32 214 475180 25655 90127398
Bronchopulmonary aspergillosis allergic 19.06 9.32 53 475341 3713 90149340
Haemorrhagic stroke 19.04 9.32 76 475318 6420 90146633
Blood creatine phosphokinase abnormal 19.04 9.32 15 475379 317 90152736
Amenorrhoea 19.03 9.32 20 475374 11702 90141351
Agitated depression 19.03 9.32 16 475378 372 90152681
Cardioactive drug level increased 19.02 9.32 40 475354 2344 90150709
Metabolic encephalopathy 19 9.32 78 475316 6674 90146379
Electrocardiogram Q wave abnormal 18.91 9.32 12 475382 177 90152876
Lower urinary tract symptoms 18.77 9.32 10 475384 104 90152949
Gout 18.77 9.32 152 475242 16707 90136346
Furuncle 18.70 9.32 84 475310 7477 90145576
Peripheral nerve palsy 18.67 9.32 7 475387 28 90153025
Hepatic cyst 18.58 9.32 76 475318 6492 90146561
Cerebral artery stenosis 18.55 9.32 19 475375 572 90152481
Subchondral insufficiency fracture 18.46 9.32 8 475386 50 90153003
Deafness 18.45 9.32 190 475204 22324 90130729
Metastases to bone 18.45 9.32 70 475324 25435 90127618
Product administration error 18.44 9.32 216 475178 26207 90126846
Photodermatosis 18.44 9.32 19 475375 576 90152477
Gouty arthritis 18.41 9.32 19 475375 577 90152476
N-terminal prohormone brain natriuretic peptide increased 18.39 9.32 45 475349 2917 90150136
Tenosynovitis 18.37 9.32 30 475364 14537 90138516
Hypertransaminasaemia 18.34 9.32 144 475250 15681 90137372
Blood lactic acid 18.28 9.32 10 475384 110 90152943
Macular oedema 18.23 9.32 62 475332 4847 90148206
Aortic valve incompetence 18.23 9.32 76 475318 6548 90146505
Ocular icterus 18.20 9.32 54 475340 3926 90149127
Subdural haemorrhage 18.15 9.32 49 475345 3374 90149679
Pathogen resistance 18.08 9.32 10 475384 8105 90144948
Muscular dystrophy 18.07 9.32 8 475386 53 90153000
Large intestinal haemorrhage 18.07 9.32 31 475363 1557 90151496
Poisoning deliberate 18.07 9.32 37 475357 16449 90136604
Cerebral mass effect 18.03 9.32 25 475369 1041 90152012
Product complaint 18.00 9.32 127 475267 13373 90139680
Mental status changes 18.00 9.32 332 475062 44347 90108706
Mitral valve disease 17.96 9.32 41 475353 2541 90150512
Percutaneous coronary intervention 17.95 9.32 13 475381 241 90152812
Albuminuria 17.94 9.32 15 475379 346 90152707
Low birth weight baby 17.94 9.32 14 475380 9453 90143600
Renal artery stenosis 17.92 9.32 37 475357 2140 90150913
Duodenitis 17.90 9.32 57 475337 4306 90148747
Essential hypertension 17.81 9.32 73 475321 6242 90146811
Diastolic dysfunction 17.79 9.32 81 475313 7252 90145801
High density lipoprotein abnormal 17.77 9.32 11 475383 155 90152898
Spinal stenosis 17.75 9.32 154 475240 17270 90135783
Vascular graft occlusion 17.71 9.32 12 475382 199 90152854
Paresis 17.68 9.32 42 475352 2672 90150381
Tricuspid valve incompetence 17.63 9.32 149 475245 16582 90136471
Peripheral coldness 17.55 9.32 129 475265 13763 90139290
Productive cough 17.55 9.32 529 474865 76534 90076519
Vascular graft 17.51 9.32 22 475372 831 90152222
Fear 17.50 9.32 148 475246 16474 90136579
SARS-CoV-2 test positive 17.45 9.32 109 475285 11019 90142034
Maternal drugs affecting foetus 17.45 9.32 3 475391 5152 90147901
End stage renal disease 17.43 9.32 90 475304 8481 90144572
Milk-alkali syndrome 17.40 9.32 27 475367 1246 90151807
Vascular stent occlusion 17.35 9.32 8 475386 59 90152994
Transplant rejection 17.31 9.32 25 475369 12733 90140320
Product dose omission in error 17.27 9.32 174 475220 20329 90132724
Patella fracture 17.27 9.32 40 475354 2503 90150550
Hypothermia 17.11 9.32 140 475254 15435 90137618
Sprue-like enteropathy 17.10 9.32 23 475371 930 90152123
Amylase increased 17.07 9.32 78 475316 6994 90146059
Initial insomnia 17.05 9.32 95 475299 9215 90143838
Aplastic anaemia 17.04 9.32 27 475367 13242 90139811
Cholangiolitis 17.02 9.32 4 475390 0 90153053
Cholestatic pruritus 17.02 9.32 4 475390 0 90153053
Hypoglobulinaemia 17.01 9.32 11 475383 168 90152885
High density lipoprotein increased 17.01 9.32 27 475367 1271 90151782
Loss of personal independence in daily activities 17.00 9.32 564 474830 135541 90017512
Smooth muscle antibody positive 16.98 9.32 10 475384 128 90152925
Prothrombin consumption time prolonged 16.96 9.32 7 475387 38 90153015
Swelling of eyelid 16.95 9.32 65 475329 5389 90147664
Orthopnoea 16.95 9.32 76 475318 6759 90146294
Chloropsia 16.91 9.32 8 475386 63 90152990
Chronic fatigue syndrome 16.89 9.32 30 475364 1549 90151504
Normochromic normocytic anaemia 16.85 9.32 62 475332 5040 90148013
Muscle haemorrhage 16.85 9.32 47 475347 3299 90149754
Urosepsis 16.84 9.32 178 475216 21054 90131999
Internal haemorrhage 16.83 9.32 71 475323 6149 90146904
Blood pressure inadequately controlled 16.81 9.32 71 475323 6153 90146900
Hypocapnia 16.81 9.32 17 475377 504 90152549
Renal cyst 16.79 9.32 121 475273 12829 90140224
Cardiomyopathy 16.79 9.32 171 475223 20035 90133018
Complication of device insertion 16.72 9.32 18 475376 10418 90142635
Cardiac flutter 16.72 9.32 58 475336 4580 90148473
Change of bowel habit 16.71 9.32 37 475357 2246 90150807
Dilatation atrial 16.70 9.32 34 475360 1947 90151106
Tuberculosis 16.62 9.32 25 475369 12524 90140529
Dopamine transporter scintigraphy abnormal 16.61 9.32 9 475385 97 90152956
Peripheral circulatory failure 16.55 9.32 30 475364 1574 90151479
Coronary artery surgery 16.53 9.32 7 475387 41 90153012
Skin oedema 16.51 9.32 25 475369 1129 90151924
Bradykinesia 16.48 9.32 75 475319 6713 90146340
Gastric polyps 16.47 9.32 58 475336 4614 90148439
Labyrinthitis 16.46 9.32 41 475353 2688 90150365
Blood electrolytes abnormal 16.45 9.32 25 475369 1133 90151920
Cardiac discomfort 16.38 9.32 25 475369 1137 90151916
Chest wall haematoma 16.36 9.32 12 475382 227 90152826
Malnutrition 16.36 9.32 159 475235 18399 90134654
Post transplant lymphoproliferative disorder 16.32 9.32 8 475386 6941 90146112
Nephrosclerosis 16.27 9.32 25 475369 1144 90151909
Idiopathic pulmonary fibrosis 16.21 9.32 30 475364 1600 90151453
Monoclonal immunoglobulin present 16.21 9.32 35 475359 2089 90150964
Gastroenteritis 16.20 9.32 229 475165 29000 90124053
Diabetic foot 16.20 9.32 30 475364 1601 90151452
Bundle branch block left 16.17 9.32 83 475311 7802 90145251
Blood glucose fluctuation 16.15 9.32 61 475333 5022 90148031
Muscle discomfort 15.99 9.32 13 475381 288 90152765
Eosinophilic fasciitis 15.95 9.32 11 475383 188 90152865
Blue toe syndrome 15.94 9.32 16 475378 470 90152583
Body temperature decreased 15.88 9.32 193 475201 23623 90129430
Exercise tolerance decreased 15.85 9.32 80 475314 7471 90145582
Cerebral microangiopathy 15.84 9.32 13 475381 292 90152761
Mitral valve calcification 15.81 9.32 25 475369 1173 90151880
Oesophageal obstruction 15.75 9.32 19 475375 688 90152365
Heavy menstrual bleeding 15.74 9.32 55 475339 20475 90132578
Vascular stent thrombosis 15.72 9.32 24 475370 1092 90151961
Entropion 15.71 9.32 9 475385 109 90152944
Multiple injuries 15.71 9.32 32 475362 1833 90151220
Lipase increased 15.69 9.32 106 475288 11005 90142048
Ankylosing spondylitis 15.68 9.32 28 475366 13105 90139948
Dizziness postural 15.68 9.32 91 475303 8962 90144091
Aortic valve replacement 15.67 9.32 22 475372 927 90152126
Lacunar infarction 15.61 9.32 46 475348 3331 90149722
Acute graft versus host disease in skin 15.59 9.32 3 475391 4753 90148300
Posture abnormal 15.59 9.32 40 475354 2671 90150382
BRASH syndrome 15.54 9.32 32 475362 1847 90151206
Carotid bruit 15.52 9.32 19 475375 699 90152354
Wrong dose 15.49 9.32 33 475361 1951 90151102
Hypoperfusion 15.49 9.32 31 475363 1753 90151300
Iron deficiency anaemia 15.45 9.32 191 475203 23471 90129582
Abdominal hernia 15.37 9.32 66 475328 5762 90147291
Wrist fracture 15.35 9.32 137 475257 15487 90137566
Psoriasis 15.31 9.32 934 474460 146820 90006233
Disturbance in attention 15.30 9.32 339 475055 46770 90106283
Lipids abnormal 15.29 9.32 13 475381 307 90152746
Type V hyperlipidaemia 15.28 9.32 21 475373 867 90152186
Tobacco interaction 15.28 9.32 8 475386 80 90152973
Arterial insufficiency 15.14 9.32 11 475383 205 90152848
Intentional product misuse 15.12 9.32 356 475038 89248 90063805
Hypertensive angiopathy 15.11 9.32 8 475386 82 90152971
Tobacco abuse 15.10 9.32 19 475375 719 90152334
Ejection fraction decreased 15.08 9.32 207 475187 26046 90127007
Escherichia urinary tract infection 15.08 9.32 124 475270 13691 90139362
Sebaceous gland infection 15.06 9.32 10 475384 160 90152893
Spontaneous haematoma 15.05 9.32 24 475370 1134 90151919
Abdominal pain 15.04 9.32 2330 473064 393391 89759662
Pancreatic carcinoma 15.03 9.32 85 475309 8292 90144761
Injection site swelling 15.01 9.32 222 475172 59617 90093436
Adenovirus infection 14.98 9.32 3 475391 4619 90148434
Eyelid haematoma 14.95 9.32 8 475386 84 90152969
Therapy cessation 14.93 9.32 271 475123 36090 90116963
Monocytosis 14.89 9.32 22 475372 972 90152081
Left atrial dilatation 14.88 9.32 32 475362 1904 90151149
Nephrotic syndrome 14.88 9.32 77 475317 7262 90145791
Low density lipoprotein decreased 14.87 9.32 12 475382 263 90152790
Maternal exposure during breast feeding 14.85 9.32 7 475387 6213 90146840
Unintended pregnancy 14.84 9.32 11 475383 7626 90145427
Ear pain 14.84 9.32 213 475181 57489 90095564
Bronchopulmonary aspergillosis 14.82 9.32 23 475371 11375 90141678
Epidermal necrosis 14.80 9.32 36 475358 2325 90150728
Choking 14.78 9.32 111 475283 11922 90141131
Ventricular internal diameter abnormal 14.78 9.32 6 475388 31 90153022
Dementia Alzheimer's type 14.77 9.32 22 475372 979 90152074
Ischaemia 14.77 9.32 61 475333 5234 90147819
Peripheral embolism 14.76 9.32 26 475368 1334 90151719
Blood chloride decreased 14.74 9.32 69 475325 6250 90146803
Patent ductus arteriosus 14.73 9.32 3 475391 4566 90148487
Ventricular septal defect 14.69 9.32 5 475389 5402 90147651
Optic ischaemic neuropathy 14.68 9.32 30 475364 1722 90151331
Oxygen saturation decreased 14.64 9.32 697 474697 106786 90046267
Basal ganglia haemorrhage 14.64 9.32 19 475375 742 90152311
Fibrosis 14.63 9.32 66 475328 5886 90147167
Abdominal pain lower 14.61 9.32 231 475163 29946 90123107
Mydriasis 14.57 9.32 36 475358 14976 90138077
Pancreatitis relapsing 14.54 9.32 26 475368 1350 90151703
Ventricular extrasystoles 14.50 9.32 119 475275 13131 90139922
Saliva altered 14.49 9.32 14 475380 392 90152661
Coronary arterial stent insertion 14.41 9.32 40 475354 2800 90150253
Blood sodium increased 14.38 9.32 43 475351 3139 90149914
Bacteraemia 14.38 9.32 64 475330 22236 90130817
Albumin urine present 14.38 9.32 12 475382 276 90152777
Craniofacial fracture 14.37 9.32 15 475379 462 90152591
Rash macular 14.36 9.32 231 475163 30049 90123004
Febrile bone marrow aplasia 14.31 9.32 18 475376 9720 90143333
Paroxysmal arrhythmia 14.29 9.32 7 475387 60 90152993
Face oedema 14.28 9.32 186 475208 23132 90129921
Full blood count decreased 14.27 9.32 227 475167 29462 90123591
Copper metabolism disorder 14.27 9.32 4 475390 4 90153049
Nodal arrhythmia 14.26 9.32 25 475369 1278 90151775
Renal abscess 14.25 9.32 23 475371 1098 90151955
Hormone receptor positive breast cancer 14.25 9.32 19 475375 762 90152291
Cardiomegaly 14.24 9.32 157 475237 18768 90134285
Unresponsive to stimuli 14.23 9.32 280 475114 37841 90115212
Hypertensive heart disease 14.21 9.32 38 475356 2602 90150451
Overdose 14.18 9.32 679 474715 157030 89996023
Upper respiratory tract infection 14.14 9.32 540 474854 127778 90025275
Oral candidiasis 14.12 9.32 263 475131 35192 90117861
Hyperinsulinaemic hypoglycaemia 14.11 9.32 9 475385 134 90152919
Electrocardiogram T wave inversion 14.11 9.32 47 475347 3636 90149417
Gait deviation 14.10 9.32 7 475387 62 90152991
Restless legs syndrome 14.08 9.32 180 475214 22290 90130763
Lip blister 14.07 9.32 40 475354 2838 90150215
Left ventricular failure 14.07 9.32 71 475323 6629 90146424
Polycystic ovaries 14.07 9.32 6 475388 5648 90147405
Prevertebral soft tissue swelling of cervical space 14.05 9.32 6 475388 36 90153017
Laryngotracheal oedema 14.05 9.32 6 475388 36 90153017
Brain stem infarction 14.05 9.32 20 475374 854 90152199
Palmar erythema 14.02 9.32 31 475363 1880 90151173
Anosmia 13.93 9.32 94 475300 9754 90143299
Hypoaesthesia oral 13.92 9.32 134 475260 15466 90137587
Hepatic failure 13.90 9.32 289 475105 39439 90113614
Infarction 13.89 9.32 41 475353 2972 90150081
Ballismus 13.89 9.32 9 475385 138 90152915
Anisocytosis 13.87 9.32 19 475375 782 90152271
Blindness 13.87 9.32 206 475188 26362 90126691
Cardiotoxicity 13.86 9.32 24 475370 11365 90141688
Atrial thrombosis 13.83 9.32 34 475360 2211 90150842
Hypotonia 13.81 9.32 105 475289 11321 90141732
Small fibre neuropathy 13.81 9.32 18 475376 706 90152347
Jaundice hepatocellular 13.78 9.32 6 475388 38 90153015
IIIrd nerve paresis 13.78 9.32 9 475385 140 90152913
Cardiovascular disorder 13.61 9.32 119 475275 13373 90139680
Humerus fracture 13.61 9.32 93 475301 9692 90143361
Endocrine ophthalmopathy 13.60 9.32 22 475372 1052 90152001
Panic attack 13.60 9.32 204 475190 26161 90126892
Cervicobrachial syndrome 13.60 9.32 23 475371 1142 90151911
Lacunar stroke 13.59 9.32 11 475383 242 90152811
Oral mucosal blistering 13.59 9.32 72 475322 6852 90146201
Aortic valve stenosis 13.57 9.32 51 475343 4189 90148864
Hyponatraemic seizure 13.54 9.32 15 475379 495 90152558
Aortic aneurysm 13.48 9.32 52 475342 4323 90148730
Cellulitis 13.46 9.32 597 474797 90740 90062313
Blood pressure abnormal 13.45 9.32 160 475234 19485 90133568
Skin abrasion 13.44 9.32 103 475291 11132 90141921
Chills 13.44 9.32 833 474561 131148 90021905
Cataract operation 13.44 9.32 66 475328 6097 90146956
Cytomegalovirus viraemia 13.41 9.32 12 475382 7574 90145479
Device difficult to use 13.40 9.32 47 475347 17478 90135575
Oesophagitis 13.40 9.32 144 475250 17105 90135948
Heart rate irregular 13.40 9.32 190 475204 24078 90128975
Diabetes mellitus management 13.39 9.32 4 475390 6 90153047
Hyperglycaemic hyperosmolar nonketotic syndrome 13.37 9.32 25 475369 1344 90151709
Clostridium test positive 13.36 9.32 60 475334 5341 90147712
Stress 13.34 9.32 538 474856 80857 90072196
Myoglobinaemia 13.34 9.32 5 475389 20 90153033
Ichthyosis 13.29 9.32 7 475387 71 90152982
Crystal urine 13.28 9.32 6 475388 42 90153011
Pancreatitis 13.23 9.32 469 474925 69357 90083696
Angioplasty 13.23 9.32 26 475368 1451 90151602
Blindness transient 13.20 9.32 53 475341 4490 90148563
Eyelid disorder 13.18 9.32 33 475361 2170 90150883
Enthesopathy 13.18 9.32 18 475376 9386 90143667
Granuloma annulare 13.10 9.32 19 475375 825 90152228
Pruritus genital 13.10 9.32 53 475341 4505 90148548
Gastritis erosive 13.09 9.32 70 475324 6685 90146368
Blood uric acid abnormal 13.09 9.32 9 475385 153 90152900
Acute left ventricular failure 13.07 9.32 24 475370 1272 90151781
Menstrual disorder 13.06 9.32 8 475386 6130 90146923
Sudden death 13.05 9.32 100 475294 10809 90142244
Pyelonephritis 13.04 9.32 170 475224 21146 90131907
Myeloma cast nephropathy 13.04 9.32 9 475385 154 90152899
Biliary fibrosis 13.01 9.32 4 475390 7 90153046
Glucose tolerance impaired 13.01 9.32 79 475315 7906 90145147
Atrioventricular block second degree 12.98 9.32 52 475342 4400 90148653
Insomnia 12.97 9.32 1541 473853 331933 89821120
Renal cell carcinoma stage IV 12.96 9.32 5 475389 22 90153031
Renovascular hypertension 12.96 9.32 5 475389 22 90153031
Xanthelasma 12.96 9.32 7 475387 75 90152978
Quadriplegia 12.91 9.32 33 475361 2198 90150855
Neck pain 12.91 9.32 478 474916 113485 90039568
Colon cancer 12.91 9.32 100 475294 10844 90142209
Parkinsonian rest tremor 12.89 9.32 9 475385 157 90152896
Stupor 12.89 9.32 60 475334 5422 90147631
Cluster headache 12.88 9.32 19 475375 838 90152215
Lung hyperinflation 12.87 9.32 25 475369 1383 90151670
Nuchal rigidity 12.87 9.32 18 475376 756 90152297
Toxic epidermal necrolysis 12.85 9.32 241 475153 32287 90120766
Cholecystitis acute 12.85 9.32 89 475305 9315 90143738
Xerosis 12.81 9.32 26 475368 1485 90151568
Intracranial haematoma 12.81 9.32 13 475381 387 90152666
Therapy interrupted 12.80 9.32 349 475045 49759 90103294
Atrial septal defect acquired 12.77 9.32 3 475391 0 90153053
Intraocular pressure increased 12.74 9.32 72 475322 7021 90146032
Breast pain 12.74 9.32 96 475298 10322 90142731
Hypergammaglobulinaemia 12.72 9.32 16 475378 605 90152448
Urinary occult blood positive 12.72 9.32 7 475387 78 90152975
Haemodialysis 12.68 9.32 84 475310 8663 90144390
Tooth fracture 12.65 9.32 111 475283 12489 90140564
Dissociation 12.63 9.32 10 475384 6705 90146348
Narrow anterior chamber angle 12.60 9.32 6 475388 48 90153005
Left ventricular dysfunction 12.60 9.32 125 475269 14544 90138509
Vascular purpura 12.54 9.32 28 475366 1710 90151343
Mean cell haemoglobin increased 12.52 9.32 47 475347 3858 90149195
Cerebrovascular arteriovenous malformation 12.49 9.32 7 475387 81 90152972
Actinic keratosis 12.49 9.32 41 475353 3147 90149906
Cerebral artery occlusion 12.48 9.32 21 475373 1038 90152015
Visual acuity reduced transiently 12.47 9.32 10 475384 217 90152836
Accelerated hypertension 12.44 9.32 14 475380 470 90152583
Bladder sphincter atony 12.43 9.32 10 475384 218 90152835
Arteriospasm coronary 12.41 9.32 56 475338 4994 90148059
Inclusion body myositis 12.36 9.32 4 475390 9 90153044
Adrenal insufficiency 12.33 9.32 99 475295 29822 90123231
Brain stem stroke 12.33 9.32 13 475381 405 90152648
Sedation 12.33 9.32 178 475216 47993 90105060
Parapsoriasis 12.32 9.32 8 475386 123 90152930
Bifascicular block 12.32 9.32 8 475386 123 90152930
Extra dose administered 12.29 9.32 86 475308 9032 90144021
Stenosis 12.24 9.32 31 475363 2053 90151000
Retinal oedema 12.24 9.32 21 475373 1055 90151998
Device related infection 12.22 9.32 82 475312 25704 90127349
Aortic dissection 12.22 9.32 34 475360 2383 90150670
Knee operation 12.19 9.32 70 475324 6866 90146187
Thirst 12.18 9.32 135 475259 16160 90136893
Cardiac arrest 12.15 9.32 670 474724 104265 90048788
Drug level increased 12.14 9.32 209 475185 27553 90125500
Gastroduodenal haemorrhage 12.13 9.32 7 475387 86 90152967
Psychotic disorder 12.12 9.32 105 475289 31125 90121928
Product odour abnormal 12.12 9.32 26 475368 1545 90151508
Injection site erythema 12.11 9.32 409 474985 98093 90054960
Large intestine infection 12.10 9.32 36 475358 2621 90150432
Exercise lack of 12.08 9.32 13 475381 415 90152638
Accidental overdose 12.06 9.32 212 475182 28061 90124992
Tendon disorder 12.03 9.32 68 475326 6632 90146421
Lipohypertrophy 12.01 9.32 17 475377 722 90152331
Muscle enzyme increased 11.98 9.32 10 475384 230 90152823
Thrombosis 11.97 9.32 484 474910 72767 90080286
Hyperuricaemia 11.94 9.32 68 475326 6651 90146402
Ureteric obstruction 11.92 9.32 31 475363 2087 90150966
Blood alkaline phosphatase 11.89 9.32 9 475385 179 90152874
Airway complication of anaesthesia 11.88 9.32 13 475381 423 90152630
Kidney fibrosis 11.87 9.32 32 475362 2202 90150851
Binocular eye movement disorder 11.85 9.32 5 475389 29 90153024
Cerebrovascular disorder 11.83 9.32 37 475357 2769 90150284
Connective tissue inflammation 11.82 9.32 6 475388 56 90152997
Femoral neck fracture 11.79 9.32 93 475301 10140 90142913
Skin swelling 11.79 9.32 67 475327 6547 90146506
Administration site discomfort 11.79 9.32 8 475386 133 90152920
Osteitis 11.76 9.32 45 475349 3728 90149325
Intracranial aneurysm 11.75 9.32 50 475344 4348 90148705
Chronic lymphocytic leukaemia 11.74 9.32 40 475354 3130 90149923
Hyperphagia 11.73 9.32 37 475357 2781 90150272
Axonal neuropathy 11.71 9.32 22 475372 1187 90151866
Leriche syndrome 11.71 9.32 5 475389 30 90153023
Arterial disorder 11.69 9.32 24 475370 1382 90151671
Illness 11.69 9.32 534 474860 81435 90071618
Blood creatinine abnormal 11.68 9.32 48 475346 4109 90148944
Muscle contracture 11.67 9.32 28 475366 1793 90151260
Malignant polyp 11.64 9.32 9 475385 185 90152868
Diverticulitis 11.62 9.32 315 475079 44872 90108181
Abdominal pain upper 11.61 9.32 1548 473846 331126 89821927
Palatal oedema 11.60 9.32 16 475378 663 90152390
Coma 11.59 9.32 291 475103 72341 90080712
Follicular lymphoma stage IV 11.57 9.32 5 475389 31 90153022
Renal tubular atrophy 11.56 9.32 19 475375 921 90152132
Arcus lipoides 11.54 9.32 4 475390 12 90153041
Toxic skin eruption 11.48 9.32 130 475264 15644 90137409
Conduction disorder 11.46 9.32 27 475367 1708 90151345
Maternal exposure during delivery 11.46 9.32 3 475391 3843 90149210
Schizophrenia 11.40 9.32 40 475354 14874 90138179
Diverticulum oesophageal 11.39 9.32 9 475385 191 90152862
Neurofibrosarcoma 11.39 9.32 9 475385 191 90152862
Lipids increased 11.39 9.32 23 475371 1309 90151744
Urine odour abnormal 11.38 9.32 71 475323 7173 90145880
Coronary artery dissection 11.35 9.32 19 475375 935 90152118
Wound haemorrhage 11.35 9.32 37 475357 2830 90150223
Transient acantholytic dermatosis 11.35 9.32 7 475387 98 90152955
Collagen disorder 11.32 9.32 10 475384 249 90152804
Exercise tolerance increased 11.31 9.32 5 475389 33 90153020
Vascular stenosis 11.29 9.32 14 475380 522 90152531
Visual acuity reduced 11.26 9.32 179 475215 23231 90129822
Nephropathy 11.24 9.32 85 475309 9150 90143903
Vertebral artery stenosis 11.23 9.32 7 475387 100 90152953
Tendon rupture 11.21 9.32 85 475309 9158 90143895
Lymphomatoid papulosis 11.20 9.32 8 475386 145 90152908
Venoocclusive liver disease 11.18 9.32 9 475385 5984 90147069
Peripheral ischaemia 11.17 9.32 59 475335 5608 90147445
Macroglossia 11.13 9.32 18 475376 861 90152192
Pericardial haemorrhage 11.12 9.32 28 475366 1848 90151205
Biopsy colon abnormal 11.11 9.32 7 475387 102 90152951
Pancreatic cyst 11.09 9.32 31 475363 2179 90150874
Lip oedema 11.07 9.32 51 475343 4588 90148465
Eosinophil cationic protein increased 11.05 9.32 6 475388 65 90152988
Lumbar vertebral fracture 11.04 9.32 72 475322 7386 90145667
Blindness unilateral 11.04 9.32 74 475320 7662 90145391
Noninfectious peritonitis 11.01 9.32 8 475386 149 90152904
Device deployment issue 11.01 9.32 6 475388 4903 90148150
Cutaneous vasculitis 10.99 9.32 70 475324 7123 90145930
Palmar-plantar erythrodysaesthesia syndrome 10.97 9.32 94 475300 27929 90125124
Blood calcium increased 10.97 9.32 104 475290 11954 90141099
Blood calcitonin increased 10.95 9.32 5 475389 36 90153017
Dermatitis bullous 10.94 9.32 92 475302 10224 90142829
Tubulointerstitial nephritis and uveitis syndrome 10.90 9.32 10 475384 262 90152791
Genital haemorrhage 10.90 9.32 18 475376 8684 90144369
Bradyarrhythmia 10.88 9.32 33 475361 2428 90150625
Acute cutaneous lupus erythematosus 10.88 9.32 11 475383 326 90152727
Lipomatosis 10.88 9.32 7 475387 106 90152947
Immobile 10.88 9.32 64 475330 6334 90146719
Death 10.87 9.32 2626 472768 453925 89699128
Chronic left ventricular failure 10.85 9.32 15 475379 623 90152430
Hepatic enzyme abnormal 10.85 9.32 73 475321 7569 90145484
Quadrantanopia 10.83 9.32 5 475389 37 90153016
Radius fracture 10.82 9.32 46 475348 3998 90149055
Intraventricular haemorrhage 10.82 9.32 33 475361 2436 90150617
Autoimmune dermatitis 10.79 9.32 8 475386 154 90152899
Spinal fusion surgery 10.75 9.32 31 475363 12252 90140801
Helicobacter gastritis 10.74 9.32 26 475368 1674 90151379
Menstruation irregular 10.73 9.32 16 475378 8044 90145009
Granulomatous dermatitis 10.71 9.32 9 475385 209 90152844
Fructosamine increased 10.70 9.32 3 475391 3 90153050
Femoral bruit 10.70 9.32 3 475391 3 90153050
Internal carotid artery deformity 10.70 9.32 3 475391 3 90153050
Stillbirth 10.69 9.32 14 475380 7429 90145624
Basilar artery stenosis 10.67 9.32 4 475390 16 90153037
Erythema marginatum 10.67 9.32 4 475390 16 90153037
Product coating issue 10.65 9.32 7 475387 110 90152943
Drug specific antibody present 10.64 9.32 8 475386 5506 90147547
Hypomania 10.60 9.32 19 475375 8878 90144175
Congenital bowing of long bones 10.59 9.32 6 475388 71 90152982
Limb discomfort 10.56 9.32 268 475126 37792 90115261
Cholangiocarcinoma 10.55 9.32 22 475372 1281 90151772
Chest injury 10.54 9.32 29 475365 2019 90151034
Glossitis 10.54 9.32 42 475352 3545 90149508
Blood immunoglobulin E increased 10.54 9.32 5 475389 4420 90148633
Rebound psychosis 10.53 9.32 9 475385 214 90152839
Multiple sclerosis relapse 10.52 9.32 202 475192 52103 90100950
Left ventricular end-diastolic pressure increased 10.52 9.32 12 475382 409 90152644
Urinary straining 10.50 9.32 5 475389 40 90153013
Alpha hydroxybutyrate dehydrogenase increased 10.48 9.32 4 475390 17 90153036
Reticulocyte percentage increased 10.48 9.32 4 475390 17 90153036
Lipoma 10.47 9.32 37 475357 2949 90150104
Essential tremor 10.47 9.32 23 475371 1389 90151664
Aneurysm 10.46 9.32 42 475352 3558 90149495
Deformity 10.45 9.32 31 475363 12139 90140914
Blood iron abnormal 10.44 9.32 4 475390 4016 90149037
Nephrogenic systemic fibrosis 10.43 9.32 46 475348 4062 90148991
Henoch-Schonlein purpura 10.40 9.32 25 475369 1602 90151451
Nasal cyst 10.40 9.32 5 475389 41 90153012
Lens dislocation 10.40 9.32 5 475389 41 90153012
Renal pain 10.35 9.32 73 475321 7686 90145367
Liver disorder 10.34 9.32 525 474869 120744 90032309
Pyelonephritis acute 10.33 9.32 56 475338 5376 90147677
Thalamus haemorrhage 10.33 9.32 16 475378 737 90152316
Cardiac ventricular disorder 10.32 9.32 8 475386 165 90152888
Rash pustular 10.32 9.32 75 475319 7974 90145079
Renal embolism 10.30 9.32 4 475390 18 90153035
Feeling hot 10.28 9.32 321 475073 77687 90075366
Drug effective for unapproved indication 10.27 9.32 16 475378 7902 90145151
Thrombotic thrombocytopenic purpura 10.26 9.32 46 475348 4092 90148961
Anaesthesia oral 10.25 9.32 3 475391 4 90153049
Cardiac amyloidosis 10.22 9.32 19 475375 1017 90152036
Mucosal membrane hyperplasia 10.20 9.32 5 475389 43 90153010
Thalamic infarction 10.19 9.32 13 475381 499 90152554
Pleurothotonus 10.19 9.32 22 475372 1313 90151740
Diverticular perforation 10.16 9.32 43 475351 3729 90149324
Post procedural haemorrhage 10.16 9.32 80 475314 8718 90144335
Stoma site haemorrhage 10.15 9.32 22 475372 1316 90151737
Pain of skin 10.15 9.32 129 475265 15953 90137100
QRS axis abnormal 10.14 9.32 21 475373 1217 90151836
Toxic shock syndrome 10.11 9.32 19 475375 1025 90152028
Anhedonia 10.11 9.32 98 475296 11333 90141720
Glomerular filtration rate abnormal 10.08 9.32 22 475372 1323 90151730
Aortic disorder 10.07 9.32 17 475377 843 90152210
Progressive multifocal leukoencephalopathy 10.05 9.32 45 475349 15610 90137443
Anal fistula 10.03 9.32 5 475389 4296 90148757
Upper limb fracture 10.01 9.32 164 475230 21414 90131639
Anal paraesthesia 9.96 9.32 4 475390 20 90153033
Barotrauma 9.92 9.32 8 475386 175 90152878
Nephrogenic anaemia 9.92 9.32 32 475362 2434 90150619
Anal polyp 9.91 9.32 6 475388 81 90152972
Coronary ostial stenosis 9.91 9.32 6 475388 81 90152972
Vitrectomy 9.90 9.32 9 475385 233 90152820
Device issue 9.89 9.32 103 475291 29434 90123619
Total complement activity increased 9.85 9.32 3 475391 5 90153048
Eyelid retraction 9.85 9.32 6 475388 82 90152971
Cardiospasm 9.85 9.32 40 475354 3406 90149647
Food interaction 9.84 9.32 21 475373 1243 90151810
Dyspepsia 9.82 9.32 900 474494 197260 89955793
Osteoporosis 9.82 9.32 410 474984 96121 90056932
Hypertension 9.79 9.32 2187 473207 455345 89697708
Frustration tolerance decreased 9.79 9.32 73 475321 7823 90145230
Splenic rupture 9.79 9.32 22 475372 1349 90151704
Diabetic complication 9.79 9.32 18 475376 955 90152098
Ligament disorder 9.77 9.32 12 475382 443 90152610
Impaired work ability 9.76 9.32 149 475245 19177 90133876
Cerebral thrombosis 9.75 9.32 26 475368 1777 90151276
Hypophosphataemia 9.74 9.32 120 475274 14734 90138319
Vascular graft infection 9.73 9.32 5 475389 48 90153005
Intracranial mass 9.72 9.32 21 475373 1254 90151799
Red blood cell count decreased 9.71 9.32 315 475079 46036 90107017
Sinus arrest 9.70 9.32 29 475365 2117 90150936
Photopsia 9.70 9.32 52 475342 4972 90148081
Renal cell carcinoma 9.69 9.32 43 475351 3808 90149245
Periorbital oedema 9.68 9.32 65 475329 6734 90146319
Eye contusion 9.68 9.32 33 475361 2583 90150470
Pancreatitis necrotising 9.67 9.32 31 475363 2350 90150703
Hepatic fibrosis marker increased 9.65 9.32 7 475387 130 90152923
Rabies 9.65 9.32 4 475390 22 90153031
Antipsychotic drug level above therapeutic 9.65 9.32 22 475372 1362 90151691
Gastrointestinal tract mucosal pigmentation 9.64 9.32 15 475379 694 90152359
Nephrolithiasis 9.63 9.32 331 475063 48754 90104299
Mandibular mass 9.62 9.32 8 475386 183 90152870
Hypercapnia 9.61 9.32 64 475330 6613 90146440
Mucormycosis 9.60 9.32 4 475390 3817 90149236
Degenerative aortic valve disease 9.59 9.32 8 475386 184 90152869
Product size issue 9.56 9.32 12 475382 453 90152600
Glomerulonephritis rapidly progressive 9.55 9.32 21 475373 1269 90151784
Gastrointestinal ischaemia 9.55 9.32 8 475386 185 90152868
Incorrect dose administered 9.54 9.32 506 474888 78424 90074629
Red cell distribution width increased 9.52 9.32 102 475292 12105 90140948
Blood bilirubin increased 9.52 9.32 297 475097 43173 90109880
Meralgia paraesthetica 9.51 9.32 13 475381 534 90152519
Compensatory sweating 9.51 9.32 4 475390 23 90153030
Arterial bypass operation 9.51 9.32 4 475390 23 90153030
Subcapsular splenic haematoma 9.51 9.32 4 475390 23 90153030
Blood pressure ambulatory abnormal 9.50 9.32 3 475391 6 90153047
Chronic cheek biting 9.50 9.32 3 475391 6 90153047
Exposure to toxic agent 9.50 9.32 17 475377 7950 90145103
Scratch 9.43 9.32 86 475308 9780 90143273
Metastases to liver 9.42 9.32 101 475293 28706 90124347
Leukocyturia 9.40 9.32 24 475370 1598 90151455
Product residue present 9.39 9.32 46 475348 4245 90148808
Post cardiac arrest syndrome 9.37 9.32 4 475390 24 90153029
Haematoma muscle 9.33 9.32 26 475368 1824 90151229

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Immune-mediated myositis 1955.51 11.84 900 442084 2893 42175458
Myalgia 1615.66 11.84 3272 439712 92808 42085543
Rhabdomyolysis 1332.63 11.84 2675 440309 75344 42103007
Off label use 797.40 11.84 3677 439307 634658 41543693
Blood creatine phosphokinase increased 660.78 11.84 1515 441469 46823 42131528
Drug abuse 578.71 11.84 184 442800 104587 42073764
Myopathy 551.84 11.84 698 442286 13063 42165288
Toxicity to various agents 548.86 11.84 963 442021 228173 41950178
Drug ineffective 547.53 11.84 4076 438908 626121 41552230
Necrotising myositis 533.18 11.84 253 442731 888 42177463
Febrile neutropenia 489.05 11.84 733 442251 184970 41993381
Myocardial infarction 448.83 11.84 2503 440481 121506 42056845
Foetal exposure during pregnancy 421.18 11.84 16 442968 47295 42131056
Acute kidney injury 302.80 11.84 5428 437556 361909 41816442
Pyrexia 300.42 11.84 2636 440348 391406 41786945
Neutropenia 293.10 11.84 1075 441909 198356 41979995
Cerebrovascular accident 286.11 11.84 1859 441125 95301 42083050
Angina pectoris 274.55 11.84 859 442125 32037 42146314
Autoimmune myositis 261.01 11.84 130 442854 521 42177830
Acute myocardial infarction 260.15 11.84 1246 441738 56919 42121432
Dizziness 249.62 11.84 3804 439180 245450 41932901
Coronary artery disease 249.15 11.84 1163 441821 52557 42125794
Myelosuppression 247.78 11.84 58 442926 40403 42137948
Chest pain 203.07 11.84 2281 440703 137249 42041102
Disease progression 202.04 11.84 788 442196 142868 42035483
Premature baby 195.76 11.84 11 442973 23142 42155209
Muscular weakness 189.66 11.84 1501 441483 81997 42096354
Treatment failure 188.15 11.84 224 442760 62400 42115951
Mucosal inflammation 181.30 11.84 148 442836 49226 42129125
Coronary artery stenosis 175.80 11.84 355 442629 10024 42168327
Drug resistance 175.49 11.84 68 442916 34180 42144171
Erectile dysfunction 171.78 11.84 610 442374 24303 42154048
Drug interaction 167.87 11.84 3791 439193 263208 41915143
Malignant neoplasm progression 160.56 11.84 582 442402 107818 42070533
Product use in unapproved indication 159.77 11.84 1191 441793 183265 41995086
Low density lipoprotein increased 153.45 11.84 231 442753 5124 42173227
Syncope 150.91 11.84 1639 441345 97767 42080584
Myositis 149.62 11.84 415 442569 14451 42163900
Atrial fibrillation 147.83 11.84 2152 440832 137441 42040910
Muscle spasms 142.99 11.84 1445 441539 84599 42093752
Ascites 140.11 11.84 233 442751 56445 42121906
Multiple organ dysfunction syndrome 135.24 11.84 534 442450 96501 42081850
Muscle rupture 134.94 11.84 146 442838 2294 42176057
Polymyositis 134.67 11.84 126 442858 1647 42176704
Drug ineffective for unapproved indication 133.52 11.84 170 442814 45993 42132358
Coronary artery occlusion 132.13 11.84 328 442656 10669 42167682
Product monitoring error 128.46 11.84 192 442792 4231 42174120
Sepsis 125.95 11.84 1394 441590 197940 41980411
Pancytopenia 125.89 11.84 713 442271 117030 42061321
Hypomagnesaemia 124.23 11.84 606 442378 27882 42150469
Cytomegalovirus infection 123.44 11.84 93 442891 32213 42146138
Drug dependence 122.88 11.84 75 442909 29019 42149332
Therapeutic product effect incomplete 122.28 11.84 356 442628 70583 42107768
Completed suicide 121.40 11.84 552 442432 95913 42082438
Platelet count decreased 119.83 11.84 895 442089 137686 42040665
Mitral valve incompetence 116.47 11.84 407 442577 16082 42162269
Ischaemic stroke 115.55 11.84 498 442486 21735 42156616
Cytokine release syndrome 113.85 11.84 179 442805 44348 42134003
Angina unstable 112.66 11.84 317 442667 11131 42167220
Neutrophil count decreased 112.41 11.84 314 442670 63101 42115250
Fall 110.23 11.84 3204 439780 231316 41947035
Type 2 diabetes mellitus 108.80 11.84 430 442554 18041 42160310
Intentional product misuse 107.88 11.84 309 442675 61591 42116760
Acute coronary syndrome 107.68 11.84 370 442614 14495 42163856
Bone marrow failure 107.48 11.84 111 442873 32982 42145369
Dyspnoea 106.85 11.84 5621 437363 437000 41741351
Graft versus host disease 106.67 11.84 7 442977 12918 42165433
Hyperkalaemia 101.36 11.84 1280 441704 79178 42099173
Respiratory depression 100.82 11.84 35 442949 18833 42159518
Mixed liver injury 100.81 11.84 173 442811 4301 42174050
Leukopenia 100.57 11.84 417 442567 74329 42104022
White blood cell count decreased 99.74 11.84 704 442280 109692 42068659
Condition aggravated 99.68 11.84 2011 440973 258743 41919608
Appendicitis 97.50 11.84 46 442938 20567 42157784
Lactic acidosis 97.47 11.84 804 442180 44457 42133894
Glycosylated haemoglobin increased 96.52 11.84 325 442659 12599 42165752
Cardiac failure 95.77 11.84 1602 441382 105254 42073097
Drug hypersensitivity 95.00 11.84 1506 441478 97883 42080468
Therapy partial responder 94.21 11.84 45 442939 19976 42158375
Drug use disorder 93.67 11.84 3 442981 10330 42168021
High density lipoprotein decreased 93.53 11.84 155 442829 3742 42174609
Cardiac failure chronic 89.76 11.84 261 442723 9340 42169011
Bronchopulmonary aspergillosis 87.91 11.84 46 442938 19383 42158968
Upper gastrointestinal haemorrhage 86.18 11.84 575 442409 29724 42148627
Glomerular filtration rate decreased 85.54 11.84 367 442617 15984 42162367
Vascular stent thrombosis 84.69 11.84 134 442850 3108 42175243
Myocardial necrosis marker increased 84.37 11.84 101 442883 1781 42176570
Melaena 84.35 11.84 690 442294 38056 42140295
Asthenia 84.13 11.84 3644 439340 277149 41901202
Tendon rupture 83.67 11.84 228 442756 7855 42170496
Pneumocystis jirovecii pneumonia 83.44 11.84 83 442901 25098 42153253
Stomatitis 82.82 11.84 258 442726 50071 42128280
Muscle necrosis 82.73 11.84 76 442908 969 42177382
Suicide attempt 82.63 11.84 227 442757 45873 42132478
Hepatitis cholestatic 82.36 11.84 257 442727 9567 42168784
Bacterial infection 82.35 11.84 101 442883 27778 42150573
Labelled drug-drug interaction medication error 80.18 11.84 348 442636 15234 42163117
Transient ischaemic attack 80.12 11.84 613 442371 33126 42145225
Blood glucose increased 79.43 11.84 1140 441844 72559 42105792
Pneumonia 78.47 11.84 3588 439396 418561 41759790
Haemophagocytic lymphohistiocytosis 78.32 11.84 46 442938 18176 42160175
Low birth weight baby 77.62 11.84 7 442977 9948 42168403
Poisoning 77.28 11.84 28 442956 14671 42163680
Cholestasis 76.76 11.84 595 442389 32284 42146067
Intentional self-injury 76.53 11.84 31 442953 15171 42163180
Bradycardia 75.99 11.84 1280 441704 84204 42094147
Rectal haemorrhage 75.71 11.84 819 442165 48787 42129564
Aspergillus infection 73.90 11.84 36 442948 15801 42162550
Presyncope 73.06 11.84 440 442544 21947 42156404
Pathogen resistance 72.95 11.84 15 442969 11435 42166916
Blood triglycerides increased 72.08 11.84 342 442642 15554 42162797
Low density lipoprotein decreased 72.07 11.84 78 442906 1226 42177125
Neurotoxicity 71.65 11.84 84 442900 23567 42154784
Disseminated intravascular coagulation 70.97 11.84 92 442892 24702 42153649
Death 70.90 11.84 4092 438892 467093 41711258
Thrombocytopenia 70.69 11.84 1474 441510 188805 41989546
Amnesia 70.53 11.84 522 442462 27915 42150436
Cytomegalovirus infection reactivation 70.48 11.84 15 442969 11163 42167188
Hepatic cytolysis 70.17 11.84 499 442485 26345 42152006
Posterior reversible encephalopathy syndrome 69.86 11.84 23 442961 12798 42165553
Serotonin syndrome 69.84 11.84 100 442884 25745 42152606
Post transplant lymphoproliferative disorder 69.56 11.84 7 442977 9113 42169238
Exposure during pregnancy 69.46 11.84 5 442979 8543 42169808
Muscle atrophy 69.42 11.84 218 442766 8143 42170208
Dermatomyositis 68.50 11.84 85 442899 1558 42176793
Sedation 68.37 11.84 133 442851 30342 42148009
Infective pulmonary exacerbation of cystic fibrosis 68.37 11.84 3 442981 7815 42170536
Pain in extremity 68.04 11.84 2048 440936 148556 42029795
Palpitations 67.77 11.84 817 442167 49980 42128371
Haematuria 67.52 11.84 907 442077 56892 42121459
Muscle disorder 67.10 11.84 117 442867 2947 42175404
Myopathy toxic 66.81 11.84 58 442926 683 42177668
Product prescribing error 66.29 11.84 482 442502 25630 42152721
Product use issue 66.13 11.84 496 442488 76255 42102096
C-reactive protein abnormal 65.94 11.84 9 442975 9252 42169099
Infection 65.91 11.84 796 442188 111272 42067079
Inferior vena cava dilatation 65.62 11.84 60 442924 760 42177591
Hypotension 65.02 11.84 3287 439697 254344 41924007
Haematotoxicity 64.81 11.84 17 442967 10968 42167383
Infusion related reaction 63.98 11.84 370 442614 60436 42117915
Septic shock 63.96 11.84 626 442358 91046 42087305
Multiple-drug resistance 63.41 11.84 3 442981 7319 42171032
Autoimmune hepatitis 63.26 11.84 164 442820 5481 42172870
Respiratory arrest 62.95 11.84 125 442859 28299 42150052
Ischaemic cardiomyopathy 62.61 11.84 179 442805 6343 42172008
Venoocclusive liver disease 62.60 11.84 15 442969 10287 42168064
Oedema peripheral 61.60 11.84 1851 441133 134225 42044126
Overdose 61.39 11.84 749 442235 104515 42073836
Pancreatitis acute 60.75 11.84 574 442410 32990 42145361
Intentional product use issue 60.57 11.84 467 442517 71366 42106985
Dyspnoea exertional 60.25 11.84 791 442193 49357 42128994
Orthostatic hypotension 60.00 11.84 532 442452 30038 42148313
Hypoglycaemia 59.46 11.84 913 442071 58941 42119410
Immune reconstitution inflammatory syndrome 57.41 11.84 17 442967 10126 42168225
Epstein-Barr virus infection 57.41 11.84 15 442969 9703 42168648
Myocardial ischaemia 57.26 11.84 348 442636 17414 42160937
Diabetic ketoacidosis 56.85 11.84 413 442571 21954 42156397
Ejection fraction decreased 56.81 11.84 409 442575 21678 42156673
Chromaturia 55.89 11.84 320 442664 15669 42162682
Neoplasm progression 55.63 11.84 138 442846 28862 42149489
Muscle injury 55.01 11.84 77 442907 1595 42176756
Cystitis haemorrhagic 54.93 11.84 6 442978 7323 42171028
Akathisia 54.79 11.84 20 442964 10431 42167920
Incorrect route of product administration 53.72 11.84 107 442877 24198 42154153
N-terminal prohormone brain natriuretic peptide increased 53.65 11.84 114 442870 3339 42175012
Blood phosphorus increased 53.29 11.84 32 442952 12493 42165858
Cardiac disorder 53.14 11.84 758 442226 48174 42130177
Cardiac failure congestive 53.12 11.84 1214 441770 84388 42093963
Pulmonary vasculitis 52.90 11.84 3 442981 6263 42172088
Psoriasis 52.82 11.84 753 442231 47851 42130500
Acute myeloid leukaemia 52.69 11.84 94 442890 22162 42156189
Product substitution issue 51.99 11.84 244 442740 11046 42167305
Idiopathic pulmonary fibrosis 50.82 11.84 133 442851 4471 42173880
Respiratory symptom 50.68 11.84 26 442958 11080 42167271
Hypocalcaemia 50.68 11.84 508 442476 29665 42148686
Dermatitis atopic 49.93 11.84 258 442726 12146 42166205
Tumour lysis syndrome 49.89 11.84 97 442887 22134 42156217
Status epilepticus 49.74 11.84 53 442931 15525 42162826
Coronary artery bypass 49.11 11.84 135 442849 4675 42173676
Nocturia 48.11 11.84 251 442733 11861 42166490
Cerebral haemorrhage 47.80 11.84 617 442367 38349 42140002
Hyperphosphataemia 47.70 11.84 39 442945 12965 42165386
Respiratory failure 47.41 11.84 993 441991 127139 42051212
Maternal exposure during pregnancy 46.89 11.84 8 442976 6970 42171381
Eosinophilic granulomatosis with polyangiitis 46.19 11.84 16 442968 8622 42169729
Somnolence 45.85 11.84 1116 441868 139989 42038362
Electrocardiogram abnormal 45.80 11.84 218 442766 9927 42168424
Haemorrhagic stroke 45.77 11.84 175 442809 7227 42171124
Hypogammaglobulinaemia 45.72 11.84 34 442950 11857 42166494
Blood cholesterol abnormal 45.22 11.84 77 442907 1902 42176449
Seizure 45.00 11.84 933 442051 119628 42058723
Intermittent claudication 44.97 11.84 88 442896 2427 42175924
Hepatocellular injury 44.90 11.84 409 442575 23269 42155082
Cytomegalovirus viraemia 44.87 11.84 26 442958 10351 42168000
Agitation 44.51 11.84 440 442544 63874 42114477
Faeces discoloured 44.30 11.84 316 442668 16698 42161653
Carotid artery stenosis 43.55 11.84 140 442844 5296 42173055
Vomiting 43.44 11.84 2516 440468 287207 41891144
Blood loss anaemia 43.07 11.84 208 442776 9528 42168823
Progressive multifocal leukoencephalopathy 43.06 11.84 34 442950 11502 42166849
Small for dates baby 42.99 11.84 3 442981 5260 42173091
Coronary artery restenosis 42.19 11.84 50 442934 872 42177479
Enterococcal infection 41.85 11.84 38 442946 12001 42166350
Hypertensive emergency 41.59 11.84 59 442925 1238 42177113
Blood cholesterol increased 41.49 11.84 443 442541 26298 42152053
Transplant rejection 41.44 11.84 48 442936 13540 42164811
Blood urea abnormal 41.36 11.84 55 442929 1083 42177268
Exercise tolerance decreased 41.35 11.84 148 442836 5918 42172433
Amyotrophic lateral sclerosis 40.81 11.84 54 442930 1058 42177293
Low density lipoprotein abnormal 40.80 11.84 34 442950 377 42177974
Myelodysplastic syndrome 40.75 11.84 112 442872 22633 42155718
Lymphocyte count decreased 40.67 11.84 150 442834 27659 42150692
Coma 40.66 11.84 358 442626 53196 42125155
Liver function test abnormal 40.62 11.84 515 442469 31876 42146475
Cytopenia 40.44 11.84 75 442909 17422 42160929
Ventricular hypokinesia 40.33 11.84 160 442824 6724 42171627
Gastrointestinal haemorrhage 40.15 11.84 1314 441670 96412 42081939
Atrial septal defect 40.11 11.84 16 442968 7903 42170448
Full blood count abnormal 39.96 11.84 167 442817 29709 42148642
Tricuspid valve incompetence 39.88 11.84 224 442760 10889 42167462
Aplastic anaemia 39.69 11.84 42 442942 12342 42166009
Blood cholesterol decreased 39.24 11.84 53 442931 1060 42177291
Hypophosphataemia 39.14 11.84 101 442883 20844 42157507
Diabetes mellitus inadequate control 39.01 11.84 284 442700 15106 42163245
Drug withdrawal syndrome 38.69 11.84 106 442878 21443 42156908
Tendonitis 38.59 11.84 204 442780 9690 42168661
Exercise lack of 38.27 11.84 21 442963 107 42178244
Restlessness 38.19 11.84 165 442819 29084 42149267
Mite allergy 38.15 11.84 4 442980 5042 42173309
BK virus infection 37.99 11.84 22 442962 8762 42169589
Heart rate irregular 37.76 11.84 291 442693 15759 42162592
Neuroleptic malignant syndrome 37.53 11.84 107 442877 21365 42156986
Toxic epidermal necrolysis 37.37 11.84 147 442837 26603 42151748
Intercepted product preparation error 37.31 11.84 15 442969 7374 42170977
Swollen tongue 36.89 11.84 360 442624 20871 42157480
Muscle enzyme increased 36.73 11.84 29 442955 296 42178055
Bacteraemia 36.66 11.84 135 442849 24905 42153446
Candida infection 36.09 11.84 110 442874 21500 42156851
Diabetic nephropathy 36.04 11.84 77 442907 2264 42176087
Neuritis 35.99 11.84 10 442974 6210 42172141
Drug-induced liver injury 35.80 11.84 578 442406 37695 42140656
Psychotic disorder 35.61 11.84 169 442815 29039 42149312
Polymyalgia rheumatica 35.30 11.84 76 442908 2247 42176104
Therapy non-responder 35.29 11.84 369 442615 52990 42125361
Paradoxical drug reaction 35.21 11.84 4 442980 4734 42173617
Balance disorder 35.14 11.84 693 442291 46952 42131399
Blood cholesterol 35.12 11.84 25 442959 215 42178136
Substance abuse 34.84 11.84 25 442959 8880 42169471
Blood uric acid increased 34.74 11.84 68 442916 15479 42162872
Nipple pain 34.19 11.84 49 442935 1038 42177313
Haematochezia 34.17 11.84 822 442162 57614 42120737
Haematoma 34.06 11.84 443 442541 27580 42150771
Immune effector cell-associated neurotoxicity syndrome 33.93 11.84 29 442955 9432 42168919
Bronchopulmonary aspergillosis allergic 33.87 11.84 4 442980 4594 42173757
Hepatitis B reactivation 33.68 11.84 4 442980 4574 42173777
Nipple swelling 33.64 11.84 30 442954 367 42177984
Intentional overdose 33.55 11.84 357 442627 51099 42127252
Foetal growth restriction 33.49 11.84 7 442977 5276 42173075
Chronic kidney disease 33.47 11.84 683 442301 46558 42131793
Ocular myasthenia 32.74 11.84 35 442949 542 42177809
Blood pressure increased 32.72 11.84 1333 441651 100595 42077756
Pollakiuria 32.69 11.84 368 442616 22137 42156214
Gait disturbance 32.23 11.84 1285 441699 96715 42081636
Muscle discomfort 32.10 11.84 23 442961 200 42178151
Vascular stent stenosis 32.02 11.84 49 442935 1103 42177248
Dust allergy 31.94 11.84 8 442976 5324 42173027
Euglycaemic diabetic ketoacidosis 31.91 11.84 130 442854 5530 42172821
Hepatic enzyme increased 31.80 11.84 660 442324 45124 42133227
Stent placement 31.74 11.84 125 442859 5235 42173116
Arrhythmia 31.64 11.84 592 442392 39725 42138626
Conjunctivitis allergic 31.52 11.84 11 442973 5900 42172451
Peripheral vascular disorder 31.48 11.84 124 442860 5193 42173158
Nodule 31.45 11.84 51 442933 12483 42165868
Dystonia 31.20 11.84 53 442931 12737 42165614
Obstructive airways disorder 30.92 11.84 142 442842 24617 42153734
Nocardiosis 30.68 11.84 8 442976 5182 42173169
Respiratory distress 30.68 11.84 282 442702 41538 42136813
Pneumothorax 30.62 11.84 133 442851 23410 42154941
International normalised ratio increased 30.45 11.84 685 442299 47483 42130868
Pseudomonas infection 30.36 11.84 76 442908 15847 42162504
Upper respiratory tract infection 30.24 11.84 286 442698 41887 42136464
Hypoalbuminaemia 30.16 11.84 74 442910 15536 42162815
Haemorrhagic transformation stroke 30.02 11.84 61 442923 1730 42176621
Venoocclusive disease 29.87 11.84 3 442981 3912 42174439
Arterial occlusive disease 29.80 11.84 108 442876 4345 42174006
Type V hyperlipidaemia 29.80 11.84 43 442941 917 42177434
Fungal infection 29.75 11.84 105 442879 19617 42158734
Computerised tomogram coronary artery abnormal 29.72 11.84 19 442965 134 42178217
Nephropathy toxic 29.36 11.84 84 442900 16754 42161597
Pruritus 29.32 11.84 2310 440674 186461 41991890
Vision blurred 28.90 11.84 747 442237 52952 42125399
Pulmonary alveolar haemorrhage 28.81 11.84 70 442914 14746 42163605
Myoglobin blood increased 28.75 11.84 94 442890 3588 42174763
Genital swelling 28.65 11.84 23 442961 241 42178110
Hepatitis C 28.59 11.84 38 442946 10095 42168256
Aggression 28.55 11.84 307 442677 43856 42134495
Loss of personal independence in daily activities 28.44 11.84 356 442628 49460 42128891
Vasculitis 28.37 11.84 97 442887 18297 42160054
Blood creatine phosphokinase MB increased 28.28 11.84 63 442921 1907 42176444
Muscle fatigue 28.13 11.84 59 442925 1712 42176639
Cardio-respiratory arrest 28.13 11.84 434 442550 58202 42120149
Carotid artery disease 28.10 11.84 40 442944 842 42177509
Cardiac aneurysm 28.00 11.84 45 442939 1058 42177293
Diffuse large B-cell lymphoma recurrent 28 11.84 8 442976 4878 42173473
Hypertransaminasaemia 28.00 11.84 178 442806 9049 42169302
Febrile bone marrow aplasia 27.89 11.84 39 442945 10142 42168209
Catatonia 27.89 11.84 15 442969 6224 42172127
Thrombotic microangiopathy 27.84 11.84 71 442913 14711 42163640
Glycogen storage disease type V 27.67 11.84 12 442972 32 42178319
Cholestatic liver injury 27.45 11.84 93 442891 3616 42174735
Peripheral arterial occlusive disease 27.36 11.84 142 442842 6696 42171655
Hepatic encephalopathy 27.24 11.84 84 442900 16358 42161993
Pneumonia fungal 27.15 11.84 33 442951 9113 42169238
Quadriparesis 27.08 11.84 69 442915 2281 42176070
Product administered to patient of inappropriate age 26.91 11.84 8 442976 4753 42173598
Polyp 26.83 11.84 107 442877 4507 42173844
Anti-neutrophil cytoplasmic antibody positive vasculitis 26.76 11.84 53 442931 1475 42176876
Dyspnoea at rest 26.72 11.84 101 442883 4148 42174203
Device related infection 26.72 11.84 114 442870 20165 42158186
Klebsiella infection 26.70 11.84 48 442936 11284 42167067
Autoimmune disorder 26.59 11.84 71 442913 2416 42175935
Miosis 26.56 11.84 63 442921 13383 42164968
Total lung capacity decreased 26.56 11.84 3 442981 3567 42174784
Degenerative mitral valve disease 26.55 11.84 23 442961 270 42178081
Chest discomfort 26.54 11.84 857 442127 62759 42115592
Angioedema 26.51 11.84 603 442381 41874 42136477
Duodenal ulcer haemorrhage 26.36 11.84 125 442859 5683 42172668
Withdrawal syndrome 26.28 11.84 73 442911 14702 42163649
Atrioventricular block second degree 25.90 11.84 99 442885 4088 42174263
Abdominal pain 25.70 11.84 1670 441314 188801 41989550
Patent ductus arteriosus 25.66 11.84 3 442981 3473 42174878
Ventricular septal defect 25.59 11.84 7 442977 4392 42173959
Urine albumin/creatinine ratio decreased 25.45 11.84 11 442973 29 42178322
Dizziness postural 25.30 11.84 153 442831 7642 42170709
Antineutrophil cytoplasmic antibody positive 25.29 11.84 7 442977 4358 42173993
Activated partial thromboplastin time prolonged 25.12 11.84 83 442901 15820 42162531
Pneumonia cytomegaloviral 25.09 11.84 6 442978 4120 42174231
Weight decreased 24.94 11.84 2497 440487 205451 41972900
Musculoskeletal pain 24.94 11.84 486 442498 32854 42145497
Subdural haematoma 24.94 11.84 358 442626 22780 42155571
Pulmonary embolism 24.93 11.84 1003 441981 118609 42059742
Essential hypertension 24.89 11.84 91 442893 3677 42174674
Synovitis 24.76 11.84 81 442903 15486 42162865
Hepatitis acute 24.72 11.84 169 442815 8806 42169545
Liver injury 24.67 11.84 306 442678 18842 42159509
Pulmonary vascular disorder 24.62 11.84 33 442951 655 42177696
Left atrial enlargement 24.62 11.84 41 442943 994 42177357
Cerebral infarction 24.57 11.84 458 442526 30711 42147640
Staphylococcal bacteraemia 24.54 11.84 49 442935 11072 42167279
Pulmonary haemorrhage 24.48 11.84 51 442933 11346 42167005
Haemorrhage intracranial 24.46 11.84 280 442704 16912 42161439
Cerebral hypoperfusion 24.38 11.84 41 442943 1002 42177349
Acute respiratory distress syndrome 24.32 11.84 198 442786 29910 42148441
Viral mutation identified 24.28 11.84 3 442981 3328 42175023
Arterial stenosis 24.24 11.84 44 442940 1145 42177206
Atrial flutter 24.12 11.84 280 442704 16971 42161380
Left atrial dilatation 24.11 11.84 67 442917 2335 42176016
Enthesopathy 24.05 11.84 10 442974 4818 42173533
Chronic coronary syndrome 24.04 11.84 22 442962 279 42178072
Product odour abnormal 23.93 11.84 38 442946 884 42177467
Virologic failure 23.91 11.84 6 442978 3988 42174363
Lymphopenia 23.87 11.84 129 442855 21434 42156917
Urinary retention 23.83 11.84 591 442393 41623 42136728
C-reactive protein increased 23.66 11.84 492 442492 63068 42115283
Large intestine polyp 23.50 11.84 171 442813 9094 42169257
Troponin increased 23.44 11.84 302 442682 18760 42159591
Pneumatosis intestinalis 23.42 11.84 10 442974 4742 42173609
Adrenal insufficiency 23.36 11.84 109 442875 18815 42159536
Musculoskeletal stiffness 23.04 11.84 442 442542 57323 42121028
Depressed level of consciousness 23.03 11.84 355 442629 47615 42130736
Hypoxia 22.90 11.84 551 442433 69235 42109116
Hepatocellular carcinoma 22.84 11.84 31 442953 8163 42170188
Fatigue 22.68 11.84 4986 437998 430655 41747696
Brain oedema 22.62 11.84 90 442894 16237 42162114
Vascular graft 22.61 11.84 50 442934 1506 42176845
Nausea 22.58 11.84 3702 439282 393097 41785254
Transplant failure 22.49 11.84 7 442977 4037 42174314
Stenosis 22.48 11.84 60 442924 2041 42176310
Ageusia 22.27 11.84 201 442783 11404 42166947
Lymph node calcification 22.25 11.84 16 442968 140 42178211
Oropharyngeal pain 22.00 11.84 310 442674 42200 42136151
Gastrointestinal angiodysplasia 21.97 11.84 31 442953 647 42177704
Ventricular enlargement 21.80 11.84 31 442953 652 42177699
Iron deficiency 21.71 11.84 52 442932 11009 42167342
Mydriasis 21.71 11.84 36 442948 8734 42169617
Herpes simplex 21.70 11.84 25 442959 7070 42171281
Infective exacerbation of chronic obstructive airways disease 21.70 11.84 58 442926 1975 42176376
Abnormal loss of weight 21.67 11.84 106 442878 4881 42173470
Peripheral artery stenosis 21.67 11.84 36 442948 871 42177480
Radiculitis brachial 21.58 11.84 9 442975 21 42178330
Systemic infection 21.46 11.84 109 442875 5096 42173255
Abscess 21.40 11.84 76 442908 14172 42164179
Scrotal pain 21.39 11.84 37 442947 926 42177425
Apparent death 21.38 11.84 6 442978 3702 42174649
Thrombosis 21.37 11.84 545 442439 67966 42110385
Potassium wasting nephropathy 21.37 11.84 13 442971 83 42178268
Vertigo 21.25 11.84 487 442497 33860 42144491
Hepatitis B 21.24 11.84 23 442961 6688 42171663
Therapeutic product effect decreased 21.16 11.84 283 442701 38867 42139484
Immunisation reaction 21.15 11.84 12 442972 66 42178285
Hiatus hernia 21.14 11.84 157 442827 8403 42169948
Brain abscess 21.14 11.84 9 442975 4275 42174076
Cardiac valve disease 21.12 11.84 81 442903 3350 42175001
Post micturition dribble 21.03 11.84 8 442976 13 42178338
Respiratory syncytial virus infection 21.02 11.84 26 442958 7126 42171225
Central obesity 21.02 11.84 32 442952 717 42177634
Cardiomyopathy 21.01 11.84 298 442686 18912 42159439
Ventricular internal diameter abnormal 20.95 11.84 17 442967 181 42178170
Lacunar infarction 20.92 11.84 78 442906 3182 42175169
Abnormal behaviour 20.88 11.84 175 442809 26276 42152075
Blood glucose decreased 20.87 11.84 233 442751 13986 42164365
Neurodermatitis 20.87 11.84 33 442951 765 42177586
Unintentional medical device removal 20.71 11.84 4 442980 3187 42175164
Orthopnoea 20.65 11.84 111 442873 5306 42173045
Extrapyramidal disorder 20.57 11.84 94 442890 16318 42162033
Neurological symptom 20.39 11.84 46 442938 9945 42168406
Pancreatitis 20.20 11.84 591 442393 42677 42135674
Palmar-plantar erythrodysaesthesia syndrome 20.19 11.84 128 442856 20454 42157897
Abnormal dreams 20.03 11.84 151 442833 8120 42170231
Pelvic mass 20.00 11.84 18 442966 223 42178128
Pulmonary valve incompetence 19.96 11.84 40 442944 1123 42177228
Cardiotoxicity 19.92 11.84 29 442955 7416 42170935
Cytomegalovirus test positive 19.88 11.84 10 442974 4309 42174042
Acquired claw toe 19.79 11.84 7 442977 8 42178343
Pemphigoid 19.71 11.84 194 442790 11273 42167078
Haematoma muscle 19.67 11.84 58 442926 2092 42176259
Staphylococcal infection 19.66 11.84 274 442710 37369 42140982
Neutropenic colitis 19.61 11.84 11 442973 4459 42173892
Confusional state 19.58 11.84 2009 440975 165588 42012763
Oesophageal carcinoma 19.50 11.84 45 442939 9651 42168700
Myocardial rupture 19.46 11.84 17 442967 202 42178149
Systemic candida 19.45 11.84 16 442968 5303 42173048
Peripheral artery occlusion 19.39 11.84 52 442932 1774 42176577
Herbal interaction 19.24 11.84 23 442961 405 42177946
Mycobacterium avium complex infection 19.21 11.84 4 442980 3023 42175328
Lip swelling 19.05 11.84 291 442693 18762 42159589
JC virus infection 19.00 11.84 4 442980 3000 42175351
Microcytic anaemia 18.97 11.84 72 442912 2963 42175388
Epilepsy 18.96 11.84 177 442807 25994 42152357
Abnormal weight gain 18.93 11.84 42 442942 1268 42177083
Discoloured vomit 18.92 11.84 31 442953 741 42177610
Rheumatoid nodule 18.92 11.84 4 442980 2991 42175360
Mean cell haemoglobin concentration abnormal 18.85 11.84 10 442974 47 42178304
Antipsychotic drug level below therapeutic 18.82 11.84 5 442979 3199 42175152
Intraventricular haemorrhage 18.66 11.84 85 442899 3799 42174552
Glomerular filtration rate abnormal 18.64 11.84 40 442944 1180 42177171
Pneumonitis 18.60 11.84 313 442671 41405 42136946
Nicotine dependence 18.60 11.84 29 442955 664 42177687
Total cholesterol/HDL ratio increased 18.59 11.84 16 442968 186 42178165
Diabetic metabolic decompensation 18.56 11.84 56 442928 2046 42176305
Transient global amnesia 18.55 11.84 22 442962 384 42177967
Cardiac failure acute 18.49 11.84 220 442764 13413 42164938
Arteriosclerosis 18.47 11.84 276 442708 17713 42160638
Bundle branch block left 18.47 11.84 123 442861 6353 42171998
Hemiparesis 18.39 11.84 268 442716 17108 42161243
Hepatosplenomegaly 18.34 11.84 13 442971 4647 42173704
Neuropathy peripheral 18.34 11.84 868 442116 100985 42077366
Ventricular dyskinesia 18.32 11.84 18 442966 251 42178100
Neuromyopathy 18.27 11.84 38 442946 1096 42177255
Altered state of consciousness 18.27 11.84 205 442779 29054 42149297
Injection site oedema 18.27 11.84 21 442963 354 42177997
Aortic aneurysm 18.15 11.84 140 442844 7583 42170768
Conjunctivitis 18.14 11.84 71 442913 12868 42165483
Blood potassium abnormal 18.11 11.84 50 442934 1736 42176615
Asphyxia 18.10 11.84 37 442947 8289 42170062
Aldolase increased 18.07 11.84 10 442974 52 42178299
Polyomavirus-associated nephropathy 18.04 11.84 19 442965 5596 42172755
Peripheral paralysis 18.02 11.84 8 442976 23 42178328
Autoimmune myocarditis 17.98 11.84 18 442966 257 42178094
Acute myeloid leukaemia recurrent 17.94 11.84 7 442977 3505 42174846
Drug intolerance 17.93 11.84 669 442315 79755 42098596
Toe amputation 17.91 11.84 69 442915 2860 42175491
Lymphoproliferative disorder 17.90 11.84 6 442978 3301 42175050
Libido decreased 17.79 11.84 102 442882 4996 42173355
Muscle contractions involuntary 17.78 11.84 54 442930 1980 42176371
Normocytic anaemia 17.73 11.84 79 442905 3498 42174853
Pleural effusion 17.70 11.84 827 442157 96339 42082012
Aspiration 17.67 11.84 111 442873 17775 42160576
Lipids abnormal 17.60 11.84 23 442961 445 42177906
Respiratory acidosis 17.60 11.84 24 442960 6307 42172044
Eye injury 17.55 11.84 35 442949 979 42177372
Iliac artery stenosis 17.52 11.84 13 442971 120 42178231
Basal ganglia haemorrhage 17.46 11.84 36 442948 1032 42177319
Euphoric mood 17.40 11.84 25 442959 6428 42171923
Avoidant personality disorder 17.37 11.84 6 442978 6 42178345
Blood test abnormal 17.34 11.84 72 442912 12834 42165517
Obsessive-compulsive disorder 17.33 11.84 27 442957 6716 42171635
Ventricular fibrillation 17.29 11.84 215 442769 29908 42148443
Drug-disease interaction 17.29 11.84 33 442951 893 42177458
Eosinophilia 17.22 11.84 456 442528 32443 42145908
Lower gastrointestinal haemorrhage 17.21 11.84 180 442804 10628 42167723
Breath sounds abnormal 17.18 11.84 66 442918 12027 42166324
Tuberculosis 17.16 11.84 51 442933 10048 42168303
Ventricular arrhythmia 17.16 11.84 118 442866 6161 42172190
Stress 17.12 11.84 340 442644 43872 42134479
Abdominal discomfort 17.07 11.84 951 442033 74304 42104047
Hyperammonaemia 17.06 11.84 35 442949 7831 42170520
Penis injury 17.02 11.84 17 442967 242 42178109
Lymphadenopathy 17.02 11.84 244 442740 33121 42145230
Penile haemorrhage 16.98 11.84 35 442949 1003 42177348
Nail avulsion 16.83 11.84 11 442973 81 42178270
Escherichia sepsis 16.78 11.84 21 442963 5726 42172625
Erythema 16.75 11.84 942 442042 107851 42070500
Device leakage 16.72 11.84 53 442931 10232 42168119
Atrioventricular block 16.69 11.84 163 442821 9452 42168899
Drug dose omission by device 16.68 11.84 22 442962 5864 42172487
Left ventricular dysfunction 16.67 11.84 188 442796 11313 42167038
Drug effective for unapproved indication 16.63 11.84 27 442957 6606 42171745
Epicondylitis 16.62 11.84 23 442961 471 42177880
Gastrointestinal tract mucosal pigmentation 16.62 11.84 25 442959 554 42177797
Memory impairment 16.61 11.84 659 442325 49563 42128788
Diffuse large B-cell lymphoma 16.60 11.84 47 442937 9407 42168944
Intracranial haematoma 16.56 11.84 25 442959 556 42177795
Vitamin D abnormal 16.55 11.84 10 442974 63 42178288
Pneumonia aspiration 16.53 11.84 395 442589 49683 42128668
Ataxia 16.48 11.84 99 442885 16026 42162325
Gastritis erosive 16.48 11.84 120 442864 6383 42171968
Device related sepsis 16.44 11.84 10 442974 3877 42174474
Osteonecrosis 16.43 11.84 97 442887 15768 42162583
Paraesthesia 16.41 11.84 927 442057 72532 42105819
Electrocardiogram ST segment depression 16.34 11.84 64 442920 2673 42175678
Diabetic neuropathy 16.32 11.84 91 442893 4411 42173940
Psychiatric decompensation 16.32 11.84 12 442972 4210 42174141
Dysmorphism 16.31 11.84 7 442977 3309 42175042
Wheezing 16.23 11.84 439 442545 54342 42124009
Testicular pain 16.23 11.84 72 442912 3182 42175169
Implantable defibrillator insertion 16.23 11.84 30 442954 792 42177559
Food interaction 16.18 11.84 34 442950 988 42177363
Inappropriate schedule of product administration 16.15 11.84 823 442161 95079 42083272
Cardiac flutter 16.14 11.84 54 442930 2086 42176265
Peripheral swelling 16.08 11.84 1117 441867 89153 42089198
Peripheral ischaemia 16.05 11.84 119 442865 6366 42171985
Agitated depression 16.02 11.84 17 442967 261 42178090
Macroglossia 15.99 11.84 23 442961 489 42177862
Herpes zoster 15.96 11.84 296 442688 38581 42139770
Blood electrolytes abnormal 15.91 11.84 34 442950 1000 42177351
Anticoagulation drug level increased 15.89 11.84 25 442959 577 42177774
Electrocardiogram ST-T change 15.89 11.84 25 442959 577 42177774
Lipodystrophy acquired 15.86 11.84 8 442976 3442 42174909
Gastrointestinal toxicity 15.79 11.84 11 442973 3968 42174383
Clostridium difficile colitis 15.72 11.84 143 442841 21109 42157242
Hepatic failure 15.67 11.84 290 442694 37810 42140541
Urosepsis 15.64 11.84 231 442753 14789 42163562
Generalised tonic-clonic seizure 15.63 11.84 187 442797 26192 42152159
Sinusitis 15.62 11.84 373 442611 46919 42131432
Hemianaesthesia 15.60 11.84 11 442973 93 42178258
Cardiac stress test abnormal 15.49 11.84 19 442965 344 42178007
Metabolic function test abnormal 15.47 11.84 16 442968 238 42178113
Non-cardiac chest pain 15.41 11.84 90 442894 4439 42173912
Left ventricular dilatation 15.35 11.84 31 442953 875 42177476
Diabetic foot 15.33 11.84 68 442916 3005 42175346
Ventricular hypertrophy 15.29 11.84 94 442890 4722 42173629
Mastitis 15.27 11.84 14 442970 178 42178173
Aortic valve replacement 15.27 11.84 32 442952 928 42177423
Wound haematoma 15.24 11.84 9 442975 54 42178297
Bilirubin conjugated abnormal 15.23 11.84 11 442973 97 42178254
Renal impairment 15.20 11.84 1337 441647 108891 42069460
Skin toxicity 15.20 11.84 28 442956 6521 42171830
Penile pain 15.19 11.84 47 442937 1741 42176610
Rhinovirus infection 15.19 11.84 28 442956 6520 42171831
Urine flow decreased 15.13 11.84 40 442944 1353 42176998
Micturition frequency decreased 15.12 11.84 19 442965 353 42177998
Dyspnoea paroxysmal nocturnal 15.10 11.84 44 442940 1576 42176775
Blood pressure fluctuation 15.09 11.84 193 442791 26715 42151636
Tachycardia 15.07 11.84 878 442106 100209 42078142
Burning feet syndrome 15.05 11.84 11 442973 99 42178252
Blood glucose abnormal 15.02 11.84 125 442859 6928 42171423
Stenotrophomonas infection 15.02 11.84 10 442974 3694 42174657
Inspiratory capacity decreased 15.02 11.84 6 442978 2961 42175390
Occupational problem environmental 15.00 11.84 6 442978 12 42178339
Renal cyst 14.96 11.84 165 442819 9874 42168477
Angiocardiogram 14.94 11.84 15 442969 215 42178136
Eructation 14.93 11.84 103 442881 5383 42172968
Alveolitis 14.91 11.84 48 442936 1817 42176534
Arteriosclerosis coronary artery 14.91 11.84 275 442709 18402 42159949
Pericardial haemorrhage 14.90 11.84 75 442909 3494 42174857
Hepatic vein dilatation 14.88 11.84 15 442969 216 42178135
Ischaemic limb pain 14.86 11.84 8 442976 39 42178312
Uveitis 14.84 11.84 48 442936 9210 42169141
Blood thyroid stimulating hormone increased 14.78 11.84 100 442884 5192 42173159
Inflammation 14.75 11.84 255 442729 33592 42144759
Hyponatraemic syndrome 14.72 11.84 14 442970 187 42178164
Human herpesvirus 6 infection 14.72 11.84 4 442980 2521 42175830
Neutropenic sepsis 14.72 11.84 101 442883 15845 42162506
Mitral valve calcification 14.67 11.84 25 442959 618 42177733
Colitis microscopic 14.64 11.84 68 442916 3065 42175286
Carotid endarterectomy 14.61 11.84 9 442975 59 42178292
Carcinoid tumour of the gastrointestinal tract 14.61 11.84 9 442975 59 42178292
Leg amputation 14.59 11.84 60 442924 2563 42175788
Glycosylated haemoglobin abnormal 14.59 11.84 17 442967 291 42178060
Tunnel vision 14.55 11.84 24 442960 577 42177774
Speech disorder developmental 14.54 11.84 3 442981 2282 42176069
Staphylococcal sepsis 14.53 11.84 65 442919 11349 42167002
Meningitis cryptococcal 14.52 11.84 8 442976 3275 42175076
Therapeutic response decreased 14.52 11.84 284 442700 36728 42141623
Portal hypertension 14.50 11.84 17 442967 4770 42173581
Lung opacity 14.41 11.84 24 442960 5813 42172538
Peritonitis 14.38 11.84 124 442860 18509 42159842
Atrioventricular block complete 14.38 11.84 181 442803 11183 42167168
Liver transplant 14.36 11.84 5 442979 2686 42175665
Gastric ulcer haemorrhage 14.36 11.84 111 442873 6016 42172335
Neurological decompensation 14.35 11.84 11 442973 3778 42174573
Systolic dysfunction 14.35 11.84 66 442918 2962 42175389
Encephalitis toxic 14.32 11.84 16 442968 261 42178090
Cells in urine 14.31 11.84 4 442980 0 42178351
Transaminases 14.31 11.84 4 442980 0 42178351
Dyskinesia 14.28 11.84 182 442802 25208 42153143
Splenomegaly 14.28 11.84 111 442873 16936 42161415
Ulcer 14.27 11.84 106 442878 16335 42162016
Obstructive pancreatitis 14.21 11.84 27 442957 728 42177623
Heart valve incompetence 14.17 11.84 43 442941 1576 42176775
Osteonecrosis of jaw 14.16 11.84 128 442856 18921 42159430
Forced expiratory volume decreased 14.10 11.84 37 442947 7593 42170758
Congenital diaphragmatic anomaly 14.06 11.84 7 442977 28 42178323
Hepatic fibrosis 14.02 11.84 18 442966 4854 42173497
Methaemoglobinaemia 14.02 11.84 24 442960 5750 42172601
Acute left ventricular failure 14.02 11.84 33 442951 1037 42177314
Hypercatabolism 14.01 11.84 5 442979 6 42178345
Epstein-Barr virus associated lymphoproliferative disorder 14.00 11.84 4 442980 2439 42175912
Thrombocytopenic purpura 13.99 11.84 37 442947 1252 42177099
Prostatomegaly 13.98 11.84 111 442873 6066 42172285
Shock haemorrhagic 13.98 11.84 242 442742 16000 42162351
Bronchial irritation 13.96 11.84 8 442976 45 42178306
Pneumonia klebsiella 13.94 11.84 14 442970 4215 42174136
Accidental exposure to product 13.90 11.84 140 442844 20253 42158098
AST/ALT ratio abnormal 13.83 11.84 6 442978 16 42178335
Pulmonary toxicity 13.79 11.84 45 442939 8610 42169741
Diabetic retinopathy 13.78 11.84 50 442934 2013 42176338
Oxygen saturation decreased 13.77 11.84 541 442443 64146 42114205
Blood creatine increased 13.77 11.84 104 442880 5596 42172755
Metastases to central nervous system 13.77 11.84 58 442926 10297 42168054
Plasmacytoma 13.76 11.84 15 442969 4349 42174002
Cold sweat 13.72 11.84 179 442805 11151 42167200
Intestinal obstruction 13.71 11.84 199 442785 26959 42151392
Blood triglycerides decreased 13.64 11.84 11 442973 116 42178235
Blood urine present 13.64 11.84 184 442800 11549 42166802
Varicella zoster virus infection 13.60 11.84 5 442979 2596 42175755
Transurethral bladder resection 13.58 11.84 6 442978 17 42178334
Meningorrhagia 13.57 11.84 11 442973 117 42178234
Systemic mycosis 13.51 11.84 4 442980 2383 42175968
Device malfunction 13.51 11.84 74 442910 12253 42166098
Haemorrhage urinary tract 13.46 11.84 50 442934 2036 42176315
Occult blood positive 13.46 11.84 83 442901 4174 42174177
Angioplasty 13.46 11.84 32 442952 1012 42177339
Bulbar palsy 13.46 11.84 16 442968 280 42178071
Haematemesis 13.42 11.84 410 442574 29789 42148562
Vascular device infection 13.41 11.84 27 442957 6083 42172268
Sinus bradycardia 13.40 11.84 223 442761 14630 42163721
QRS axis abnormal 13.40 11.84 40 442944 1453 42176898
Liver palpable 13.37 11.84 16 442968 282 42178069
Lacunar stroke 13.37 11.84 16 442968 282 42178069
Loss of consciousness 13.32 11.84 1124 441860 91230 42087121
Chills 13.31 11.84 821 442163 93245 42085106
Drug screen positive 13.25 11.84 14 442970 4117 42174234
Dyslipidaemia 13.23 11.84 153 442831 9265 42169086
Behaviour disorder 13.19 11.84 34 442950 7020 42171331
Gastrointestinal inflammation 13.18 11.84 17 442967 4575 42173776
Hypertensive crisis 13.10 11.84 163 442821 10043 42168308
Normal tension glaucoma 13.10 11.84 6 442978 19 42178332
Muscle strain 13.09 11.84 87 442897 4490 42173861
Colitis 13.09 11.84 376 442608 46196 42132155
Anaphylactic reaction 13.07 11.84 341 442643 42402 42135949
Abnormal clotting factor 12.97 11.84 9 442975 74 42178277
Acute lymphocytic leukaemia 12.95 11.84 10 442974 3421 42174930
Vitreous detachment 12.95 11.84 31 442953 985 42177366
Brain stem haematoma 12.91 11.84 11 442973 126 42178225
Atrial thrombosis 12.89 11.84 55 442929 2389 42175962
Blood creatine phosphokinase abnormal 12.89 11.84 18 442966 372 42177979
Aortic valve stenosis 12.86 11.84 64 442920 2968 42175383
Electrocardiogram QRS complex prolonged 12.83 11.84 104 442880 5719 42172632
Ileus 12.79 11.84 132 442852 19007 42159344
Respiratory tract infection viral 12.76 11.84 10 442974 3396 42174955
Hypovolaemic shock 12.76 11.84 142 442842 8517 42169834
Atheroembolism 12.74 11.84 17 442967 336 42178015
Disinhibition 12.72 11.84 13 442971 3882 42174469
Laryngeal haematoma 12.70 11.84 12 442972 159 42178192
Lung disorder 12.70 11.84 390 442594 47533 42130818
Vascular access site occlusion 12.68 11.84 8 442976 55 42178296
Diverticulum 12.68 11.84 127 442857 7414 42170937
Gangrene 12.65 11.84 94 442890 5032 42173319
Cystitis radiation 12.64 11.84 11 442973 130 42178221
Immobile 12.60 11.84 61 442923 2797 42175554
Stem cell transplant 12.58 11.84 6 442978 2666 42175685
Spur cell anaemia 12.56 11.84 8 442976 56 42178295
Enterococcal bacteraemia 12.54 11.84 6 442978 2661 42175690
Dysstasia 12.53 11.84 211 442773 13875 42164476
Blood lactate dehydrogenase increased 12.52 11.84 193 442791 25888 42152463
Hyperinsulinaemic hypoglycaemia 12.50 11.84 11 442973 132 42178219
Miller Fisher syndrome 12.50 11.84 11 442973 132 42178219
Benign pancreatic neoplasm 12.50 11.84 5 442979 10 42178341
Blood pressure inadequately controlled 12.49 11.84 61 442923 2807 42175544
Head injury 12.47 11.84 291 442693 20291 42158060
Drug abuser 12.45 11.84 11 442973 3520 42174831
Arthralgia 12.44 11.84 2367 440617 202871 41975480
Atrial enlargement 12.42 11.84 25 442959 704 42177647
Blood glucose fluctuation 12.41 11.84 86 442898 4501 42173850
Glycosylated haemoglobin decreased 12.41 11.84 19 442965 428 42177923
Multiple sclerosis relapse 12.36 11.84 92 442892 14172 42164179
Electrolyte imbalance 12.36 11.84 248 442736 16853 42161498
Pulmonary tuberculosis 12.34 11.84 24 442960 5477 42172874
Blood immunoglobulin E increased 12.31 11.84 72 442912 3553 42174798
Mitral valve repair 12.25 11.84 6 442978 23 42178328
Lipid metabolism disorder 12.24 11.84 20 442964 477 42177874
Inferior vena cava syndrome 12.23 11.84 8 442976 59 42178292
High density lipoprotein abnormal 12.23 11.84 8 442976 59 42178292
Primary biliary cholangitis 12.23 11.84 16 442968 310 42178041
Drug level increased 12.20 11.84 195 442789 26005 42152346
Aphthous ulcer 12.18 11.84 27 442957 5874 42172477
Jaundice 12.18 11.84 457 442527 34132 42144219
Swelling 12.13 11.84 457 442527 54428 42123923
Vascular graft occlusion 12.10 11.84 22 442962 573 42177778
Gamma-glutamyltransferase abnormal 12.09 11.84 19 442965 438 42177913
Vomiting projectile 12.07 11.84 26 442958 769 42177582
Loss of control of legs 12.02 11.84 27 442957 822 42177529
Ketoacidosis 12.02 11.84 96 442888 5256 42173095
Fungaemia 12.01 11.84 9 442975 3127 42175224
Laziness 12.00 11.84 19 442965 441 42177910
Myoglobin urine present 11.99 11.84 11 442973 140 42178211
Personality change 11.99 11.84 101 442883 5618 42172733
Ludwig angina 11.98 11.84 13 442971 205 42178146
Injection site reaction 11.97 11.84 105 442879 15616 42162735
Exposure to toxic agent 11.97 11.84 21 442963 4983 42173368
Amyloid related imaging abnormality-oedema/effusion 11.87 11.84 24 442960 678 42177673

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Immune-mediated myositis 3541.17 10.28 1414 783232 4772 109799881
Rhabdomyolysis 2957.22 10.28 3949 780697 116452 109688201
Myalgia 2925.49 10.28 5476 779170 216905 109587748
Acute kidney injury 1751.21 10.28 9012 775634 626418 109178235
Maternal exposure during pregnancy 1493.46 10.28 76 784570 254807 109549846
Hand deformity 1319.84 10.28 53 784593 218453 109586200
Pemphigus 1309.86 10.28 48 784598 214522 109590131
Blood creatine phosphokinase increased 1167.51 10.28 1961 782685 71116 109733537
Synovitis 1145.39 10.28 269 784377 273823 109530830
Myocardial infarction 1141.47 10.28 3473 781173 188610 109616043
Myopathy 1134.48 10.28 1126 783520 23834 109780819
Glossodynia 1095.18 10.28 141 784505 221863 109582790
Duodenal ulcer perforation 1060.15 10.28 47 784599 177653 109627000
Systemic lupus erythematosus 1059.98 10.28 251 784395 254087 109550566
Cerebrovascular accident 1018.90 10.28 3215 781431 178069 109626584
Pericarditis 1009.62 10.28 170 784476 218944 109585709
Helicobacter infection 967.05 10.28 88 784558 181789 109622864
Drug ineffective 958.96 10.28 6595 778051 1513945 108290708
Necrotising myositis 946.13 10.28 399 784247 1603 109803050
Drug interaction 925.59 10.28 6396 778250 493787 109310866
Folliculitis 919.20 10.28 71 784575 167582 109637071
Exposure during pregnancy 892.85 10.28 80 784566 167344 109637309
Rheumatoid factor positive 883.77 10.28 9 784637 131631 109673022
Off label use 879.13 10.28 6644 778002 1493541 108311112
Treatment failure 848.83 10.28 454 784192 276780 109527873
Irritable bowel syndrome 805.75 10.28 106 784540 164109 109640544
Infusion related reaction 786.89 10.28 927 783719 380235 109424418
Rheumatic fever 782.38 10.28 18 784628 122561 109682092
Wound 776.77 10.28 345 784301 234092 109570561
Acute myocardial infarction 774.21 10.28 1786 782860 81991 109722662
Arthropathy 713.21 10.28 595 784051 286927 109517726
Impaired healing 708.09 10.28 255 784391 196462 109608191
Coronary artery disease 679.75 10.28 1544 783102 70146 109734507
Stomatitis 670.57 10.28 559 784087 269683 109534970
Contraindicated product administered 665.01 10.28 475 784171 247792 109556861
Therapeutic product effect decreased 635.53 10.28 482 784164 243834 109560819
Drug intolerance 635.50 10.28 1198 783448 405314 109399339
Muscle injury 629.48 10.28 118 784528 140689 109663964
Sleep disorder due to general medical condition, insomnia type 623.33 10.28 30 784616 105613 109699040
Fibromyalgia 612.63 10.28 223 784423 170686 109633967
Alopecia 595.01 10.28 1047 783599 363706 109440947
Swelling 565.04 10.28 1016 783630 350025 109454628
Atrial fibrillation 552.76 10.28 3143 781503 226499 109578154
Angina pectoris 547.10 10.28 1302 783344 60993 109743660
Psoriatic arthropathy 539.40 10.28 367 784279 196394 109608259
Swollen joint count increased 538.93 10.28 11 784635 83650 109721003
Lip dry 538.49 10.28 46 784600 100037 109704616
Facet joint syndrome 536.39 10.28 39 784607 96789 109707864
Breast cancer stage III 532.94 10.28 5 784641 79112 109725541
C-reactive protein abnormal 518.87 10.28 139 784507 129556 109675097
Hypomagnesaemia 506.83 10.28 1240 783406 59130 109745523
Hyperkalaemia 495.04 10.28 2093 782553 133703 109670950
Fall 487.79 10.28 6475 778171 597007 109207646
Ill-defined disorder 485.59 10.28 253 784393 156600 109648053
Drug abuse 482.17 10.28 334 784312 177077 109627576
Lactic acidosis 478.64 10.28 1599 783047 91212 109713441
Autoimmune myositis 478.05 10.28 201 784445 800 109803853
Live birth 474.85 10.28 3 784643 69481 109735172
Syncope 459.37 10.28 2729 781917 199807 109604846
Product use issue 456.43 10.28 954 783692 310741 109493912
Discomfort 455.95 10.28 510 784136 214197 109590456
Hypersensitivity 454.58 10.28 1414 783232 402584 109402069
Joint range of motion decreased 433.15 10.28 161 784485 121671 109682982
Bursitis 427.35 10.28 193 784453 129725 109674928
Cholestasis 408.81 10.28 1194 783452 63324 109741329
Blister 390.55 10.28 631 784015 226745 109577908
Toxicity to various agents 382.12 10.28 1931 782715 478624 109326029
Joint swelling 373.21 10.28 1743 782903 441102 109363551
Intentional product use issue 372.00 10.28 748 783898 247158 109557495
Product use in unapproved indication 358.32 10.28 1793 782853 445584 109359069
Hepatic enzyme increased 350.41 10.28 1138 783508 319754 109484899
Hypoglycaemia 348.67 10.28 1690 782956 114414 109690239
Bradycardia 346.48 10.28 2086 782560 153431 109651222
Cardiac failure 345.84 10.28 2399 782247 185227 109619426
Myelosuppression 341.57 10.28 121 784525 94219 109710434
Infection 339.62 10.28 1369 783277 360831 109443822
Musculoskeletal stiffness 338.03 10.28 947 783699 278875 109525778
Ischaemic stroke 336.23 10.28 838 783808 40425 109764228
Mixed liver injury 326.97 10.28 416 784230 11663 109792990
Blood glucose increased 324.24 10.28 1822 782824 130674 109673979
Blepharospasm 322.20 10.28 16 784630 54835 109749818
Wound infection 320.87 10.28 141 784505 96324 109708329
Grip strength decreased 320.52 10.28 86 784560 80088 109724565
Peripheral venous disease 320.13 10.28 99 784547 84018 109720635
Inflammation 320.02 10.28 549 784097 192689 109611964
Febrile neutropenia 311.19 10.28 1175 783471 315592 109489061
Melaena 310.66 10.28 1134 783512 67623 109737030
Injury 309.04 10.28 487 784159 176778 109627875
Coronary artery stenosis 305.27 10.28 430 784216 13328 109791325
Hepatitis cholestatic 304.18 10.28 489 784157 17077 109787576
Mobility decreased 303.73 10.28 781 783865 236641 109568012
Pregnancy 302.86 10.28 14 784632 51053 109753600
Abdominal discomfort 301.49 10.28 1603 783043 392255 109412398
Gastrointestinal haemorrhage 300.12 10.28 2108 782538 163410 109641243
Lower respiratory tract infection 294.89 10.28 821 783825 242285 109562368
Rheumatoid arthritis 293.89 10.28 1112 783534 298501 109506152
Angina unstable 289.43 10.28 461 784185 15971 109788682
Onychomadesis 286.44 10.28 8 784638 45655 109758998
Sinusitis 282.11 10.28 1115 783531 295573 109509080
Autoimmune hepatitis 281.18 10.28 430 784216 14374 109790279
Polymyositis 279.95 10.28 223 784423 3485 109801168
Muscular weakness 275.48 10.28 2835 781811 245633 109559020
Cardiac failure congestive 275.45 10.28 1926 782720 149074 109655579
Adjustment disorder with depressed mood 267.03 10.28 10 784636 43873 109760780
Coronary artery occlusion 266.21 10.28 434 784212 15338 109789315
Transient ischaemic attack 264.78 10.28 1026 783620 62956 109741697
C-reactive protein increased 263.51 10.28 737 783909 217182 109587471
Dislocation of vertebra 262.53 10.28 11 784635 43710 109760943
Hepatic cytolysis 256.36 10.28 917 783729 54136 109750517
Erectile dysfunction 256.01 10.28 467 784179 18089 109786564
Nail disorder 255.80 10.28 50 784596 57885 109746768
Chest pain 255.36 10.28 3918 780728 372457 109432196
Lower limb fracture 252.39 10.28 109 784537 75239 109729414
X-ray abnormal 249.64 10.28 4 784642 38113 109766540
Condition aggravated 248.67 10.28 3693 780953 731143 109073510
Acute coronary syndrome 241.87 10.28 518 784128 22594 109782059
Anaemia 238.33 10.28 5315 779331 541771 109262882
Diabetic ketoacidosis 237.91 10.28 748 783898 41310 109763343
Renal failure 235.09 10.28 2551 782095 224023 109580630
Liver function test abnormal 234.51 10.28 1041 783605 67909 109736744
Cerebral haemorrhage 234.05 10.28 998 783648 63970 109740683
Dizziness 233.80 10.28 6546 778100 691647 109113006
Gastrointestinal disorder 232.07 10.28 906 783740 241046 109563607
Dyspnoea 231.09 10.28 9823 774823 1097049 108707604
Night sweats 227.95 10.28 374 784272 133609 109671044
Pancreatitis acute 224.99 10.28 936 783710 59338 109745315
Wheezing 224.70 10.28 988 783658 254242 109550411
Lupus vulgaris 224.29 10.28 3 784643 33880 109770773
Haematuria 220.92 10.28 1168 783478 81837 109722816
Type 2 diabetes mellitus 218.27 10.28 594 784052 176638 109628015
Haematochezia 216.86 10.28 1484 783162 114040 109690613
Nasopharyngitis 215.88 10.28 1775 782871 392586 109412067
Upper gastrointestinal haemorrhage 215.23 10.28 813 783833 49283 109755370
Hypotension 214.97 10.28 5047 779599 518802 109285851
Myositis 214.77 10.28 594 784052 30522 109774131
Completed suicide 214.14 10.28 937 783709 241444 109563209
Bone erosion 213.41 10.28 36 784610 46335 109758318
Glycosylated haemoglobin increased 213.13 10.28 499 784147 23120 109781533
Hyponatraemia 210.96 10.28 2418 782228 215235 109589418
Labelled drug-drug interaction medication error 209.85 10.28 567 784079 28735 109775918
Pyrexia 206.17 10.28 4828 779818 893437 108911216
Dry mouth 205.27 10.28 728 783918 199220 109605433
Renal impairment 201.64 10.28 2135 782511 186310 109618343
Product monitoring error 199.53 10.28 280 784366 8647 109796006
Rectal haemorrhage 199.23 10.28 1495 783151 118338 109686315
C-reactive protein 195.29 10.28 4 784642 30327 109774326
Retinitis 194.55 10.28 8 784638 32319 109772334
Myocardial ischaemia 192.76 10.28 518 784128 26166 109778487
Mitral valve incompetence 192.43 10.28 597 784049 32732 109771921
Hepatocellular injury 188.68 10.28 786 783860 49856 109754797
Obesity 188.57 10.28 321 784325 113030 109691623
Asthenia 183.03 10.28 6281 778365 682718 109121935
Coeliac disease 183.00 10.28 41 784605 43146 109761507
Migraine 180.88 10.28 618 784028 171034 109633619
Lung disorder 180.53 10.28 662 783984 179385 109625268
Prescribed overdose 180.45 10.28 213 784433 87368 109717285
Muscle necrosis 179.99 10.28 128 784518 1669 109802984
Osteoarthritis 169.29 10.28 693 783953 181930 109622723
Breast cancer stage II 167.39 10.28 6 784640 27369 109777284
Dehydration 167.13 10.28 2850 781796 276661 109527992
Drug ineffective for unapproved indication 166.72 10.28 296 784350 102542 109702111
Glomerular filtration rate decreased 166.55 10.28 518 784128 28438 109776215
Blood cholesterol increased 166.45 10.28 709 783937 184076 109620577
Low density lipoprotein increased 165.97 10.28 283 784363 10383 109794270
Cardiac disorder 165.25 10.28 1016 783630 75264 109729389
Neutropenia 164.37 10.28 1781 782865 372839 109431814
Product prescribing error 164.10 10.28 761 783885 50570 109754083
Autoimmune disorder 164.07 10.28 134 784512 65349 109739304
Hypocalcaemia 163.25 10.28 904 783742 64462 109740191
Urticaria 162.88 10.28 1461 783185 317396 109487257
Red blood cell sedimentation rate increased 162.86 10.28 189 784457 78113 109726540
Chromaturia 160.42 10.28 516 784130 28844 109775809
Hip arthroplasty 159.81 10.28 99 784547 55714 109748939
Chronic kidney disease 159.55 10.28 1007 783639 75284 109729369
International normalised ratio increased 158.90 10.28 1108 783538 85664 109718989
Sciatica 158.02 10.28 257 784389 92142 109712511
Weight increased 157.68 10.28 2064 782582 417580 109387073
Drug resistance 157.30 10.28 103 784543 56271 109748382
Diabetes mellitus inadequate control 151.68 10.28 511 784135 29264 109775389
Presyncope 151.33 10.28 718 783928 48169 109756484
Cholestatic liver injury 151.15 10.28 222 784424 7154 109797499
Pain 150.25 10.28 5405 779241 949550 108855103
Blood pressure increased 148.87 10.28 2619 782027 255754 109548899
Hypertensive emergency 146.41 10.28 148 784498 3203 109801450
Cardiac failure chronic 146.20 10.28 311 784335 13500 109791153
Jaundice 145.78 10.28 816 783830 58420 109746233
Product label confusion 142.13 10.28 4 784642 22673 109781980
Device expulsion 142.12 10.28 24 784622 30867 109773786
Epilepsy 142.12 10.28 312 784334 99897 109704756
Muscle rupture 140.79 10.28 166 784480 4294 109800359
Hypercholesterolaemia 139.68 10.28 270 784376 90567 109714086
Dysarthria 138.41 10.28 1047 783599 83074 109721579
Dyspnoea exertional 137.79 10.28 1233 783413 102827 109701826
Blood triglycerides increased 137.59 10.28 428 784218 23498 109781155
Haemorrhage intracranial 136.97 10.28 485 784161 28484 109776169
Hypoaesthesia 136.15 10.28 1498 783148 312725 109491928
Ischaemic cardiomyopathy 135.96 10.28 221 784425 7790 109796863
Liver injury 135.53 10.28 577 784069 149836 109654817
Therapeutic product effect incomplete 134.70 10.28 981 783665 222824 109581829
Sleep disorder 132.83 10.28 844 783802 197800 109606853
Haematoma 132.46 10.28 788 783858 57688 109746965
Injection site reaction 132.44 10.28 270 784376 88800 109715853
Hemiparesis 132.42 10.28 640 784006 43263 109761390
Premature delivery 131.98 10.28 28 784618 30604 109774049
Onychomycosis 131.83 10.28 54 784592 38477 109766176
Incorrect route of product administration 131.75 10.28 156 784490 63905 109740748
Knee arthroplasty 131.62 10.28 160 784486 64788 109739865
Myocardial necrosis marker increased 130.16 10.28 149 784497 3731 109800922
Eosinophilia 128.86 10.28 777 783869 57159 109747494
Adverse event 128.52 10.28 372 784274 108437 109696216
Maternal exposure timing unspecified 127.13 10.28 5 784641 21008 109783645
Pemphigoid 127.00 10.28 367 784279 19340 109785313
Hepatitis acute 126.31 10.28 355 784291 18411 109786242
Mucosal inflammation 126.17 10.28 312 784334 95829 109708824
Drug tolerance decreased 125.37 10.28 22 784624 27518 109777135
Orthostatic hypotension 124.87 10.28 852 783794 65397 109739256
Cytomegalovirus infection 123.72 10.28 122 784524 54322 109750331
Rash 123.53 10.28 4671 779975 816293 108988360
Palpitations 122.65 10.28 1695 782951 157517 109647136
Blood loss anaemia 122.32 10.28 342 784304 17683 109786970
Vascular stent thrombosis 121.73 10.28 149 784497 4012 109800641
Road traffic accident 121.21 10.28 375 784271 107023 109697630
Subdural haematoma 118.41 10.28 543 784103 35911 109768742
Faeces discoloured 118.04 10.28 516 784130 33432 109771221
Intentional self-injury 117.84 10.28 59 784587 37370 109767283
Carotid artery stenosis 116.41 10.28 224 784422 9039 109795614
Polymyalgia rheumatica 115.20 10.28 182 784464 6260 109798393
Back injury 115.05 10.28 100 784546 47299 109757354
Gait inability 114.52 10.28 537 784109 135839 109668814
Neurologic neglect syndrome 112.17 10.28 221 784425 9077 109795576
Myopathy toxic 111.56 10.28 85 784561 1240 109803413
High density lipoprotein decreased 110.96 10.28 168 784478 5565 109799088
Euglycaemic diabetic ketoacidosis 110.86 10.28 251 784395 11372 109793281
Hemiplegia 109.93 10.28 384 784262 22398 109782255
Haematemesis 109.53 10.28 757 783889 58351 109746302
Carotid artery thrombosis 107.82 10.28 222 784424 9416 109795237
Therapy non-responder 107.41 10.28 664 783982 156643 109648010
Abortion spontaneous 106.49 10.28 55 784591 34227 109770426
Electrocardiogram abnormal 106.04 10.28 333 784313 18376 109786277
Ear infection 105.85 10.28 176 784470 62556 109742097
Cerebral infarction 104.53 10.28 678 783968 51160 109753493
Drug use disorder 103.87 10.28 6 784640 18068 109786585
Swollen tongue 103.67 10.28 759 783887 59603 109745050
Porphyria acute 102.76 10.28 8 784638 18772 109785881
Hyperglycaemia 102.47 10.28 988 783658 84102 109720551
Weight decreased 102.16 10.28 4176 780470 463881 109340772
Muscle atrophy 100.51 10.28 262 784384 12992 109791661
Hypokalaemia 99.61 10.28 1834 782812 180614 109624039
Dysuria 98.15 10.28 748 783898 59483 109745170
Malignant neoplasm progression 98.02 10.28 780 783866 173787 109630866
Product substitution issue 98.01 10.28 373 784273 22688 109781965
Chronic obstructive pulmonary disease 97.87 10.28 1195 783451 107963 109696690
Metabolic acidosis 96.96 10.28 1109 783537 98635 109706018
Atrioventricular block 96.21 10.28 301 784345 16576 109788077
Disease progression 95.76 10.28 1189 783457 242845 109561808
Respiratory depression 95.52 10.28 54 784592 31947 109772706
Urinary retention 95.51 10.28 832 783814 68851 109735802
Epistaxis 94.80 10.28 1374 783272 128998 109675655
Atrioventricular block complete 94.76 10.28 336 784310 19746 109784907
Contusion 94.22 10.28 1130 783516 232231 109572422
Blood creatinine increased 94.19 10.28 1822 782824 181067 109623586
Diabetes mellitus 93.50 10.28 1098 783548 98283 109706370
Angioedema 92.55 10.28 1088 783558 97412 109707241
Dermatomyositis 92.30 10.28 134 784512 4272 109800381
Myoglobin blood increased 92.01 10.28 131 784515 4101 109800552
Laryngitis 91.88 10.28 99 784547 42312 109762341
Aphasia 91.88 10.28 725 783921 58272 109746381
Lip swelling 90.42 10.28 643 784003 50024 109754629
Arrhythmia 90.36 10.28 821 783825 68754 109735899
Oedema peripheral 90.26 10.28 3009 781637 325651 109479002
Arterial occlusive disease 90.03 10.28 276 784370 15032 109789621
Neutrophil count decreased 89.21 10.28 498 784148 120443 109684210
Taste disorder 89.12 10.28 208 784438 65179 109739474
Tendon rupture 88.63 10.28 260 784386 13818 109790835
Exostosis 88.16 10.28 118 784528 45838 109758815
Graft versus host disease 87.88 10.28 14 784632 18792 109785861
Chest discomfort 87.18 10.28 1725 782921 172123 109632530
Immunodeficiency 87.13 10.28 88 784558 38750 109765903
Intentional product misuse 86.63 10.28 569 784077 132335 109672318
Red blood cell sedimentation rate abnormal 86.06 10.28 33 784613 24476 109780177
Personality disorder 85.58 10.28 242 784404 12595 109792058
Ejection fraction decreased 85.09 10.28 539 784107 40341 109764312
Haemophagocytic lymphohistiocytosis 84.92 10.28 60 784586 31499 109773154
Infective pulmonary exacerbation of cystic fibrosis 84.60 10.28 5 784641 14766 109789887
Bronchopulmonary aspergillosis 84.08 10.28 54 784592 29809 109774844
Oedema 83.91 10.28 1019 783627 208957 109595696
Finger deformity 83.79 10.28 67 784579 33025 109771628
Inferior vena cava dilatation 83.55 10.28 63 784583 904 109803749
Therapy partial responder 83.12 10.28 84 784562 36977 109767676
Nocturia 82.52 10.28 287 784359 16703 109787950
Adjustment disorder 82.49 10.28 214 784432 10581 109794072
Therapeutic response decreased 82.18 10.28 378 784268 96121 109708532
Arteriosclerosis 81.24 10.28 370 784276 24397 109780256
Caesarean section 81.24 10.28 4 784642 13813 109790840
Dermatitis atopic 81.15 10.28 378 784268 25163 109779490
Infusion site reaction 80.76 10.28 14 784632 17668 109786985
Dysphagia 80.37 10.28 1534 783112 152066 109652587
Large intestine polyp 80.16 10.28 263 784383 14854 109789799
Lupus-like syndrome 80.03 10.28 103 784543 40689 109763964
Pulmonary fibrosis 79.79 10.28 412 784234 101630 109703023
Sensory loss 79.11 10.28 332 784314 21125 109783528
Cytokine release syndrome 78.26 10.28 247 784399 70059 109734594
Haemorrhagic stroke 77.75 10.28 245 784401 13544 109791109
Foetal death 77.14 10.28 11 784635 16034 109788619
Vascular stent stenosis 77.02 10.28 73 784573 1456 109803197
Aspergillus infection 76.78 10.28 43 784603 25573 109779080
Cytomegalovirus infection reactivation 76.48 10.28 18 784628 18315 109786338
Intentional overdose 76.26 10.28 588 784058 131913 109672740
Adverse reaction 76.09 10.28 59 784587 29535 109775118
N-terminal prohormone brain natriuretic peptide increased 75.67 10.28 147 784499 5974 109798679
Suicide attempt 75.57 10.28 427 784219 102967 109701686
Atrial flutter 75.57 10.28 357 784289 23905 109780748
Muscle spasms 75.43 10.28 2543 782103 275614 109529039
Disorientation 74.74 10.28 799 783847 69872 109734781
Ocular myasthenia 74.67 10.28 54 784592 724 109803929
Gamma-glutamyltransferase increased 74.37 10.28 713 783933 60596 109744057
Multiple-drug resistance 74.25 10.28 5 784641 13230 109791423
Coronary artery restenosis 73.99 10.28 64 784582 1128 109803525
Head injury 73.92 10.28 541 784105 42476 109762177
Eating disorder 73.88 10.28 422 784224 30436 109774217
Pollakiuria 72.65 10.28 550 784096 43645 109761008
Hypertensive crisis 71.85 10.28 353 784293 24019 109780634
Electrocardiogram QT prolonged 71.72 10.28 1129 783517 107831 109696822
Coronary artery bypass 70.95 10.28 142 784504 5900 109798753
Blood glucose decreased 70.43 10.28 403 784243 29085 109775568
Blood cholesterol abnormal 70.00 10.28 108 784538 3638 109801015
Abnormal loss of weight 69.98 10.28 195 784451 10062 109794591
Low density lipoprotein decreased 69.94 10.28 67 784579 1355 109803298
Peripheral arterial occlusive disease 69.92 10.28 183 784463 9097 109795556
Epstein-Barr virus infection 69.60 10.28 23 784623 18715 109785938
Leukopenia 69.40 10.28 697 783949 148094 109656559
Idiopathic pulmonary fibrosis 69.11 10.28 126 784520 4878 109799775
Urinary tract infection 68.81 10.28 2901 781745 323381 109481272
Rheumatoid nodule 68.54 10.28 29 784617 20267 109784386
Ascites 68.53 10.28 382 784264 92426 109712227
Blood creatine phosphokinase MB increased 67.79 10.28 93 784553 2810 109801843
Drug-induced liver injury 67.64 10.28 1213 783433 118854 109685799
Haemorrhagic transformation stroke 67.49 10.28 95 784551 2942 109801711
Balance disorder 67.24 10.28 1182 783464 115378 109689275
Neurotoxicity 67.04 10.28 123 784523 42084 109762569
Vision blurred 66.97 10.28 1287 783359 127735 109676918
Cardiac failure acute 66.93 10.28 343 784303 23735 109780918
Asthma 66.51 10.28 1313 783333 248978 109555675
Post transplant lymphoproliferative disorder 65.79 10.28 15 784631 15598 109789055
Panniculitis 65.60 10.28 15 784631 15567 109789086
Hepatic cirrhosis 65.57 10.28 252 784394 67374 109737279
Adenovirus infection 65.23 10.28 3 784643 10991 109793662
Pathogen resistance 65.10 10.28 22 784624 17650 109787003
Duodenal ulcer 64.36 10.28 292 784354 19222 109785431
Troponin increased 64.16 10.28 396 784250 29370 109775283
Drug tolerance 64.03 10.28 19 784627 16566 109788087
Motor dysfunction 63.94 10.28 342 784304 24064 109780589
Disability 63.87 10.28 72 784574 30151 109774502
Prescribed underdose 63.75 10.28 242 784404 64932 109739721
Temperature regulation disorder 63.56 10.28 8 784638 12818 109791835
Tubulointerstitial nephritis 63.25 10.28 626 784020 53658 109750995
Arteriosclerosis coronary artery 63.12 10.28 348 784298 24770 109779883
Vertigo 62.93 10.28 915 783731 85955 109718698
Alveolar osteitis 62.82 10.28 56 784590 1029 109803624
Polyp 62.53 10.28 184 784462 9796 109794857
Adverse drug reaction 62.37 10.28 465 784181 105094 109699559
Sedation 62.33 10.28 268 784378 69415 109735238
Haematotoxicity 62.31 10.28 36 784610 21046 109783607
Affect lability 62.31 10.28 280 784366 18357 109786296
Appendicitis 62.15 10.28 66 784580 28398 109776255
Poisoning 61.88 10.28 69 784577 29036 109775617
Joint destruction 61.78 10.28 4 784642 10939 109793714
Bone marrow failure 61.77 10.28 207 784439 57641 109747012
Urinary tract discomfort 61.60 10.28 53 784593 927 109803726
Interstitial lung disease 61.51 10.28 1357 783289 137977 109666676
Blood urea increased 60.78 10.28 627 784019 54330 109750323
Multi-organ disorder 59.74 10.28 95 784551 3286 109801367
Muscle disorder 59.15 10.28 140 784506 6532 109798121
Pneumocystis jirovecii pneumonia 58.99 10.28 135 784511 42600 109762053
Seronegative arthritis 58.96 10.28 11 784635 13166 109791487
Tricuspid valve incompetence 58.82 10.28 329 784317 23544 109781109
Diarrhoea 58.57 10.28 9072 775574 1130433 108674220
Haemoglobin decreased 58.11 10.28 2236 782410 246491 109558162
Lethargy 57.99 10.28 960 783686 92616 109712037
Acute myeloid leukaemia 57.95 10.28 114 784532 37996 109766657
Hypoacusis 57.87 10.28 438 784208 34753 109769900
Foot deformity 57.78 10.28 165 784481 48315 109756338
Loss of consciousness 57.67 10.28 1812 782834 194494 109610159
Food allergy 57.64 10.28 35 784611 19913 109784740
Thyroid disorder 57.53 10.28 256 784390 16713 109787940
Blood cholesterol decreased 57.48 10.28 83 784563 2633 109802020
Anti-neutrophil cytoplasmic antibody positive vasculitis 57.36 10.28 122 784524 5295 109799358
Blood urea abnormal 57.33 10.28 69 784577 1825 109802828
Tunnel vision 57.09 10.28 71 784575 1944 109802709
Electrolyte imbalance 57.09 10.28 454 784192 36574 109768079
Mucormycosis 56.84 10.28 5 784641 10623 109794030
Subarachnoid haemorrhage 56.57 10.28 383 784263 29319 109775334
Therapeutic drug monitoring analysis not performed 56.25 10.28 69 784577 1862 109802791
Back pain 56.09 10.28 3193 781453 367803 109436850
Pulmonary oedema 56.02 10.28 1015 783631 99644 109705009
Diabetic nephropathy 55.80 10.28 94 784552 3414 109801239
Joint dislocation 55.77 10.28 98 784548 34092 109770561
Gangrene 55.76 10.28 247 784399 16094 109788559
Ventricular tachycardia 55.52 10.28 571 784075 49438 109755215
Pancytopenia 55.26 10.28 1101 783545 208512 109596141
Coordination abnormal 55.24 10.28 337 784309 24891 109779762
Pallor 54.94 10.28 628 784018 55839 109748814
Systemic infection 54.94 10.28 174 784472 9645 109795008
Ketoacidosis 54.85 10.28 177 784469 9910 109794743
Transplant rejection 54.73 10.28 56 784590 24511 109780142
Aplastic anaemia 54.62 10.28 55 784591 24253 109780400
Peripheral vascular disorder 54.58 10.28 159 784487 8417 109796236
Dementia 54.23 10.28 398 784248 31275 109773378
Cardiomyopathy 53.86 10.28 415 784231 33110 109771543
Low density lipoprotein abnormal 53.74 10.28 39 784607 526 109804127
Shock haemorrhagic 53.49 10.28 354 784292 26893 109777760
Subacute cutaneous lupus erythematosus 53.49 10.28 113 784533 4881 109799772
Hepatic steatosis 53.48 10.28 556 784090 48275 109756378
Type V hyperlipidaemia 53.28 10.28 59 784587 1423 109803230
Cerebral haematoma 53.27 10.28 170 784476 9462 109795191
Hyperlipidaemia 52.27 10.28 434 784212 35414 109769239
Intermittent claudication 52.14 10.28 94 784552 3607 109801046
Dyslipidaemia 51.99 10.28 238 784408 15727 109788926
Hypovolaemic shock 51.72 10.28 223 784423 14360 109790293
Heart rate irregular 51.62 10.28 418 784228 33856 109770797
White blood cell count decreased 51.51 10.28 1236 783410 228154 109576499
Sinus bradycardia 51.35 10.28 372 784274 29111 109775542
Eye haemorrhage 51.33 10.28 192 784454 11582 109793071
Blood alkaline phosphatase increased 51.32 10.28 747 783899 70188 109734465
Arthralgia 51.15 10.28 4799 779847 774833 109029820
Venoocclusive liver disease 50.92 10.28 22 784624 15185 109789468
Gastritis 50.37 10.28 593 784053 53106 109751547
Ventricular hypertrophy 50.12 10.28 136 784510 6909 109797744
Injection site erythema 50.02 10.28 427 784219 93749 109710904
Hypertransaminasaemia 49.98 10.28 319 784327 23936 109780717
Premature labour 49.92 10.28 4 784642 9168 109795485
Sickle cell anaemia with crisis 49.70 10.28 5 784641 9540 109795113
Bacterial infection 49.66 10.28 164 784482 45872 109758781
Blood iron decreased 49.49 10.28 268 784378 18946 109785707
Loss of personal independence in daily activities 49.14 10.28 758 783888 149262 109655391
Blood potassium increased 48.73 10.28 403 784243 32846 109771807
Urinary tract obstruction 48.49 10.28 111 784535 5066 109799587
Acute respiratory failure 48.46 10.28 777 783869 74483 109730170
Lower gastrointestinal haemorrhage 48.40 10.28 259 784387 18227 109786426
Cardiac murmur 48.36 10.28 320 784326 24308 109780345
Hallucination 48.35 10.28 999 783647 100433 109704220
Respiratory arrest 48.09 10.28 231 784415 58068 109746585
Flatulence 48.08 10.28 574 784072 51575 109753078
Spur cell anaemia 48.07 10.28 22 784624 112 109804541
Circulatory collapse 47.78 10.28 491 784155 42502 109762151
Atrioventricular block first degree 47.77 10.28 214 784432 14011 109790642
Cardiac aneurysm 47.07 10.28 60 784586 1685 109802968
Polyuria 46.76 10.28 249 784397 17489 109787164
Graft versus host disease in skin 46.65 10.28 3 784643 8251 109796402
Skin haemorrhage 46.60 10.28 319 784327 24508 109780145
Pre-eclampsia 46.45 10.28 4 784642 8646 109796007
Microcytic anaemia 46.22 10.28 122 784524 6096 109798557
Cataract 46.18 10.28 807 783839 78678 109725975
Blood pressure decreased 46.17 10.28 1106 783540 113985 109690668
Nipple swelling 46.17 10.28 31 784615 366 109804287
Stent placement 45.92 10.28 134 784512 7100 109797553
Cardiac valve disease 45.72 10.28 124 784522 6297 109798356
Product quality issue 45.43 10.28 341 784305 76958 109727695
Peripheral artery stenosis 45.42 10.28 52 784594 1302 109803351
Cough 45.33 10.28 3834 780812 457807 109346846
Rales 45.33 10.28 316 784330 24423 109780230
Gastric ulcer 45.29 10.28 457 784189 39370 109765283
Diabetic metabolic decompensation 45.19 10.28 91 784555 3798 109800855
Atrioventricular block second degree 44.89 10.28 144 784502 8037 109796616
Transaminases increased 44.85 10.28 665 783981 62725 109741928
Ventricular hypokinesia 44.10 10.28 177 784469 11037 109793616
Urosepsis 44.00 10.28 370 784276 30305 109774348
Cytomegalovirus viraemia 43.69 10.28 37 784609 17727 109786926
Duodenal ulcer haemorrhage 43.68 10.28 141 784505 7896 109796757
Cystitis haemorrhagic 43.60 10.28 16 784630 12193 109792460
Immune reconstitution inflammatory syndrome 43.46 10.28 31 784615 16195 109788458
Muscle discomfort 43.46 10.28 32 784614 442 109804211
Dysgeusia 43.37 10.28 718 783928 69267 109735386
Dysstasia 43.21 10.28 390 784256 32596 109772057
Exercise tolerance decreased 43.16 10.28 185 784461 11882 109792771
Gastritis erosive 42.94 10.28 184 784462 11816 109792837
Intraventricular haemorrhage 42.93 10.28 110 784536 5397 109799256
Left atrial enlargement 42.78 10.28 57 784589 1674 109802979
Exercise lack of 42.71 10.28 33 784613 492 109804161
Inappropriate antidiuretic hormone secretion 42.71 10.28 397 784249 33454 109771199
Autoantibody positive 42.69 10.28 21 784625 129 109804524
Arterial stenosis 42.63 10.28 55 784591 1564 109803089
Musculoskeletal pain 42.52 10.28 981 783665 182042 109622611
Blood glucose abnormal 42.40 10.28 193 784453 12723 109791930
Anuria 42.32 10.28 307 784339 24034 109780619
Blood parathyroid hormone decreased 42.16 10.28 20 784626 13069 109791584
Ageusia 42.12 10.28 261 784385 19384 109785269
Aortic aneurysm 41.93 10.28 160 784486 9744 109794909
Blood sodium decreased 41.81 10.28 436 784210 37883 109766770
Lacunar infarction 41.41 10.28 118 784528 6168 109798485
Swelling face 41.33 10.28 901 783745 91420 109713233
Dizziness postural 41.23 10.28 209 784437 14400 109790253
Nightmare 40.91 10.28 439 784207 38424 109766229
Unintentional medical device removal 40.90 10.28 7 784639 8916 109795737
Walking aid user 40.79 10.28 72 784574 25003 109779650
Serotonin syndrome 40.72 10.28 249 784397 58904 109745749
Calculus urinary 40.57 10.28 77 784569 3075 109801578
Muscle enzyme increased 40.17 10.28 32 784614 500 109804153
Diverticulum intestinal haemorrhagic 40.14 10.28 98 784548 4665 109799988
Platelet count decreased 40.07 10.28 1287 783359 229156 109575497
Pain in extremity 39.87 10.28 3993 780653 483125 109321528
Upper respiratory tract infection 39.86 10.28 673 783973 130655 109673998
Prostatomegaly 39.78 10.28 91 784555 4151 109800502
Scrotal pain 39.67 10.28 33 784613 550 109804103
Agitated depression 39.47 10.28 33 784613 554 109804099
Progressive multifocal leukoencephalopathy 39.39 10.28 73 784573 24883 109779770
Skin exfoliation 39.10 10.28 855 783791 86796 109717857
Potentiating drug interaction 38.98 10.28 175 784471 11468 109793185
Basal ganglia haemorrhage 38.94 10.28 57 784589 1831 109802822
Diverticulum 38.94 10.28 215 784431 15311 109789342
Orthopnoea 38.68 10.28 168 784478 10853 109793800
Carotid artery disease 38.64 10.28 62 784584 2161 109802492
Gastric ulcer haemorrhage 38.64 10.28 158 784488 9936 109794717
Ear congestion 38.18 10.28 82 784564 3583 109801070
Gestational diabetes 38.14 10.28 4 784642 7385 109797268
Dyspnoea at rest 37.98 10.28 138 784508 8208 109796445
Ventricular internal diameter abnormal 37.97 10.28 23 784623 224 109804429
Hepatitis toxic 37.90 10.28 110 784536 5811 109798842
Blood urine present 37.78 10.28 298 784348 23947 109780706
Blood creatine increased 37.70 10.28 172 784474 11349 109793304
Posterior reversible encephalopathy syndrome 37.65 10.28 119 784527 33742 109770911
Retinal artery occlusion 37.50 10.28 89 784557 4160 109800493
Ulcer haemorrhage 37.45 10.28 64 784582 22507 109782146
Sinus disorder 37.44 10.28 376 784270 32352 109772301
Diabetic retinopathy 37.43 10.28 80 784566 3484 109801169
Pericardial haemorrhage 37.40 10.28 101 784545 5116 109799537
Gastrointestinal procedural complication 37.33 10.28 29 784617 436 109804217
Alanine aminotransferase increased 37.15 10.28 1627 783019 182146 109622507
Overdose 37.07 10.28 1321 783325 232473 109572180
Sedation complication 37.06 10.28 52 784594 19803 109784850
Eructation 36.84 10.28 197 784449 13860 109790793
Essential hypertension 36.77 10.28 131 784515 7716 109796937
Primary biliary cholangitis 36.51 10.28 48 784598 1391 109803262
Cell death 36.50 10.28 107 784539 5684 109798969
Diabetic neuropathy 36.43 10.28 121 784525 6878 109797775
Diabetic foot 36.38 10.28 86 784560 4009 109800644
Computerised tomogram coronary artery abnormal 36.35 10.28 19 784627 135 109804518
Abnormal dreams 36.18 10.28 183 784463 12597 109792056
Hypovolaemia 35.77 10.28 270 784376 21404 109783249
Mouth swelling 35.52 10.28 124 784522 7230 109797423
Hepatic function abnormal 35.48 10.28 857 783789 88438 109716215
Bladder pain 35.46 10.28 68 784578 2737 109801916
Haemorrhage 35.43 10.28 1000 783646 105692 109698961
Left atrial dilatation 35.21 10.28 78 784568 3482 109801171
Pustular psoriasis 35.13 10.28 27 784619 13578 109791075
Left ventricular hypertrophy 34.97 10.28 186 784460 13058 109791595
Hiatus hernia 34.95 10.28 324 784322 27282 109777371
Maternal exposure before pregnancy 34.88 10.28 5 784641 7260 109797393
Lymphocyte count decreased 34.85 10.28 250 784396 56993 109747660
Mydriasis 34.81 10.28 65 784581 22092 109782561
Body height decreased 34.79 10.28 158 784488 10405 109794248
Bundle branch block left 34.72 10.28 182 784464 12706 109791947
Quadriparesis 34.63 10.28 92 784554 4615 109800038
Ear pain 34.61 10.28 228 784418 52998 109751655
Amyloid related imaging abnormality-oedema/effusion 34.61 10.28 49 784597 1526 109803127
Amyotrophic lateral sclerosis 34.56 10.28 57 784589 2034 109802619
Uterine perforation 34.55 10.28 4 784642 6836 109797817
Respiratory symptom 34.52 10.28 33 784613 14912 109789741
Renal cyst 34.41 10.28 234 784412 17938 109786715
Gynaecomastia 34.34 10.28 146 784500 9344 109795309
Blood creatine phosphokinase abnormal 34.10 10.28 33 784613 676 109803977
Metastases to central nervous system 34.05 10.28 69 784577 22748 109781905
Penile pain 34.00 10.28 42 784604 1142 109803511
Peripheral ischaemia 33.92 10.28 162 784484 10896 109793757
Labile blood pressure 33.85 10.28 62 784584 2409 109802244
Insomnia 33.56 10.28 2156 782490 358434 109446219
Ventricular enlargement 33.52 10.28 33 784613 691 109803962
Pancreatitis 33.42 10.28 885 783761 92648 109712005
Osteoporosis 33.27 10.28 427 784219 86725 109717928
Haematoma muscle 33.25 10.28 83 784563 4007 109800646
Nipple pain 33.18 10.28 41 784605 1115 109803538
Human herpesvirus 6 infection 32.87 10.28 4 784642 6577 109798076
Hypokinesia 32.77 10.28 266 784380 21560 109783093
Pulmonary vasculitis 32.73 10.28 4 784642 6556 109798097
Stenosis 32.67 10.28 73 784573 3278 109801375
Enterococcal infection 32.66 10.28 59 784587 20307 109784346
Respiratory disorder 32.61 10.28 336 784310 71046 109733607
Renal injury 32.53 10.28 236 784410 18477 109786176
Animal scratch 32.52 10.28 52 784594 1807 109802846
Genital swelling 32.50 10.28 26 784620 409 109804244
Underdose 32.49 10.28 291 784355 63263 109741390
Neoplasm progression 32.48 10.28 297 784349 64298 109740355
Pulmonary vascular disorder 32.39 10.28 39 784607 1032 109803621
Degenerative mitral valve disease 32.21 10.28 23 784623 302 109804351
Candida infection 32.06 10.28 204 784442 47805 109756848
Subdural haemorrhage 32.04 10.28 111 784535 6447 109798206
Left ventricular dysfunction 31.92 10.28 280 784366 23213 109781440
Fungal infection 31.85 10.28 220 784426 50586 109754067
Musculoskeletal chest pain 31.84 10.28 329 784317 28518 109776135
Intracranial haematoma 31.84 10.28 38 784608 996 109803657
Myelodysplastic syndrome 31.81 10.28 147 784499 37337 109767316
Juvenile idiopathic arthritis 31.66 10.28 3 784643 6004 109798649
Hypervolaemia 31.60 10.28 510 784136 48950 109755703
Neuromyopathy 31.45 10.28 50 784596 1729 109802924
Breast cancer stage I 31.32 10.28 7 784639 7380 109797273
Lipoprotein (a) increased 31.29 10.28 16 784630 108 109804545
Blood magnesium decreased 31.28 10.28 246 784400 19750 109784903
Overweight 31.23 10.28 109 784537 6355 109798298
Gait disturbance 31.09 10.28 2334 782312 275874 109528779
Sinus node dysfunction 31.06 10.28 137 784509 8910 109795743
Rectal polyp 31.05 10.28 46 784600 1494 109803159
Aortic valve incompetence 30.92 10.28 157 784489 10824 109793829
Gout 30.92 10.28 396 784250 36170 109768483
Amyloid related imaging abnormality-microhaemorrhages and haemosiderin deposits 30.76 10.28 43 784603 1323 109803330
Psychotic disorder 30.75 10.28 223 784423 50714 109753939
Enthesopathy 30.68 10.28 26 784620 12452 109792201
Cholelithiasis 30.34 10.28 625 784021 62797 109741856
Movement disorder 30.25 10.28 393 784253 36011 109768642
Coma 30.19 10.28 622 784024 117247 109687406
Foetal exposure during pregnancy 30.09 10.28 8 784638 7497 109797156
Vascular device infection 30.07 10.28 44 784602 16468 109788185
Atrial thrombosis 30.02 10.28 83 784563 4263 109800390
Nasal oedema 29.98 10.28 6 784640 6833 109797820
Pneumonia 29.98 10.28 5622 779024 871092 108933561
Carotid artery occlusion 29.97 10.28 141 784505 9424 109795229
Tongue oedema 29.86 10.28 127 784519 8129 109796524
Cardiotoxicity 29.76 10.28 46 784600 16835 109787818
Testicular pain 29.62 10.28 58 784588 2371 109802282
Liver disorder 29.60 10.28 775 783871 141468 109663185
Device dislocation 29.55 10.28 120 784526 31584 109773069
Infective exacerbation of chronic obstructive airways disease 29.44 10.28 68 784578 3122 109801531
Chronic coronary syndrome 29.39 10.28 21 784625 276 109804377
Macular degeneration 29.36 10.28 258 784388 21401 109783252
Ventricular extrasystoles 29.31 10.28 267 784379 22374 109782279
Feeling hot 29.26 10.28 462 784184 90644 109714009
Blood test abnormal 29.25 10.28 104 784542 28450 109776203
Ecchymosis 29.19 10.28 217 784429 17121 109787532
Dystonia 29.18 10.28 90 784556 25715 109778938
Muscle fatigue 29.15 10.28 78 784568 3929 109800724
Tinnitus 29.09 10.28 597 784049 59943 109744710
Delirium 29.08 10.28 732 783914 134293 109670360
Hypophagia 29.04 10.28 530 784116 52096 109752557
Device related infection 28.98 10.28 163 784483 39356 109765297
Vascular graft 28.71 10.28 53 784593 2072 109802581
Paradoxical drug reaction 28.68 10.28 17 784629 9800 109794853
Peripheral swelling 28.61 10.28 2472 782174 401562 109403091
Tumour lysis syndrome 28.44 10.28 117 784529 30684 109773969
Bacteraemia 28.37 10.28 180 784466 42210 109762443
Spirometry abnormal 28.31 10.28 3 784643 5494 109799159
Neck pain 28.30 10.28 661 783985 122469 109682184
Muscle haemorrhage 28.29 10.28 110 784536 6759 109797894
Oestradiol decreased 28.27 10.28 13 784633 67 109804586
Nodule 28.27 10.28 127 784519 32504 109772149
Infarction 28.24 10.28 92 784554 5177 109799476
Embolic stroke 28.22 10.28 130 784516 8613 109796040
Psoriasis 28.20 10.28 1239 783407 138754 109665899
Intestinal haemorrhage 28.17 10.28 115 784531 7226 109797427
Nocardiosis 28.14 10.28 9 784637 7477 109797176
Hepatitis B reactivation 28.13 10.28 9 784637 7475 109797178
Colitis microscopic 28.12 10.28 177 784469 13217 109791436
Vascular purpura 28.04 10.28 74 784572 3697 109800956
Peripheral artery occlusion 28.00 10.28 63 784583 2842 109801811
BK virus infection 27.94 10.28 31 784615 13075 109791578
Aspartate aminotransferase increased 27.83 10.28 1395 783251 158541 109646112
Abortion induced 27.82 10.28 11 784635 8008 109796645
Deafness 27.79 10.28 301 784345 26408 109778245
Central obesity 27.78 10.28 51 784595 1985 109802668
Blood electrolytes abnormal 27.75 10.28 52 784594 2056 109802597
Acute lymphocytic leukaemia recurrent 27.75 10.28 4 784642 5783 109798870
Cardiogenic shock 27.74 10.28 566 784080 56772 109747881
Lipase increased 27.73 10.28 227 784419 18445 109786208
Product complaint 27.71 10.28 182 784464 13790 109790863
Troponin T increased 27.56 10.28 80 784566 4226 109800427
Pneumatosis intestinalis 27.52 10.28 13 784633 8516 109796137
Optic ischaemic neuropathy 27.47 10.28 78 784568 4069 109800584
Cytopenia 27.44 10.28 115 784531 30001 109774652
Hyperinsulinaemic hypoglycaemia 27.42 10.28 20 784626 272 109804381
Myocardial rupture 27.36 10.28 20 784626 273 109804380
Gouty arthritis 27.12 10.28 45 784601 1614 109803039
Device difficult to use 27.11 10.28 58 784588 18747 109785906
Substance abuse 27.10 10.28 29 784617 12434 109792219
Limb injury 27.08 10.28 396 784250 37240 109767413
Speech disorder 26.96 10.28 599 784047 60970 109743683
Amenorrhoea 26.95 10.28 16 784630 9215 109795438
Carotid arteriosclerosis 26.94 10.28 64 784582 2993 109801660
Acute left ventricular failure 26.92 10.28 54 784592 2247 109802406
Cardiac flutter 26.88 10.28 96 784550 5661 109798992
Renal disorder 26.85 10.28 497 784149 48982 109755671
Glomerular filtration rate abnormal 26.79 10.28 55 784591 2328 109802325
Aldolase increased 26.77 10.28 18 784628 213 109804440
Diffuse large B-cell lymphoma recurrent 26.65 10.28 6 784640 6293 109798360
QRS axis abnormal 26.61 10.28 56 784590 2412 109802241
Heavy menstrual bleeding 26.61 10.28 47 784599 16318 109788335
Injection site swelling 26.55 10.28 295 784351 61495 109743158
Neutropenic colitis 26.48 10.28 12 784634 8053 109796600
Liver function test increased 26.47 10.28 455 784191 88093 109716560
Gastrointestinal angiodysplasia 26.44 10.28 38 784608 1200 109803453
Drug hypersensitivity 26.39 10.28 3642 781004 450448 109354205
Disseminated intravascular coagulation 26.27 10.28 178 784468 41108 109763545
Duodenitis 26.26 10.28 132 784514 9064 109795589
Depressed mood 26.12 10.28 590 784056 60219 109744434
Lipoprotein (a) decreased 26.12 10.28 11 784635 44 109804609
Cold sweat 26.12 10.28 255 784391 21776 109782877
Pulmonary renal syndrome 26.05 10.28 31 784615 810 109803843
Confusional state 25.90 10.28 3748 780898 464932 109339721
Food interaction 25.78 10.28 51 784595 2101 109802552
Mitral valve calcification 25.77 10.28 45 784601 1683 109802970
Macroglossia 25.74 10.28 41 784605 1420 109803233
Penile haemorrhage 25.73 10.28 32 784614 876 109803777
Cholecystitis acute 25.71 10.28 196 784450 15586 109789067
Mite allergy 25.63 10.28 5 784641 5798 109798855
Gastrointestinal tract mucosal pigmentation 25.54 10.28 38 784608 1239 109803414
International normalised ratio abnormal 25.53 10.28 101 784545 6256 109798397
Status epilepticus 25.51 10.28 126 784520 31445 109773208
Adrenal insufficiency 25.38 10.28 186 784460 42204 109762449
Heart rate decreased 25.38 10.28 768 783878 81988 109722665
Vascular stent occlusion 25.29 10.28 19 784627 271 109804382
Multiple sclerosis relapse 25.26 10.28 231 784415 50009 109754644
Spondylitis 25.08 10.28 26 784620 11312 109793341
Occult blood positive 25.00 10.28 112 784534 7333 109797320
Diverticulum intestinal 24.69 10.28 155 784491 11564 109793089
Arterial insufficiency 24.66 10.28 21 784625 362 109804291
Tuberculosis 24.65 10.28 56 784590 17718 109786935
Bradyarrhythmia 24.53 10.28 84 784562 4850 109799803
Akathisia 24.49 10.28 53 784593 17060 109787593
Exposure via ingestion 24.42 10.28 3 784643 4897 109799756
Hallucination, visual 24.42 10.28 406 784240 39199 109765454
Hyperlactacidaemia 24.41 10.28 120 784526 8166 109796487
Blood pressure systolic increased 24.34 10.28 766 783880 82225 109722428
Total lung capacity decreased 24.29 10.28 10 784636 7104 109797549
Prostate cancer recurrent 24.27 10.28 32 784614 930 109803723
Febrile bone marrow aplasia 24.24 10.28 55 784591 17410 109787243
Prostatic specific antigen increased 24.23 10.28 162 784484 12349 109792304
Hypogammaglobulinaemia 24.16 10.28 68 784578 20008 109784645
Lichen planopilaris 24.02 10.28 15 784631 155 109804498
Urinary incontinence 23.97 10.28 481 784165 48106 109756547
Aortic valve replacement 23.81 10.28 42 784604 1584 109803069
Blood glucose fluctuation 23.77 10.28 113 784533 7585 109797068
Photosensitivity reaction 23.74 10.28 282 784364 25307 109779346
Palatal oedema 23.72 10.28 43 784603 1657 109802996
Menstrual disorder 23.67 10.28 3 784643 4781 109799872
Left ventricular failure 23.60 10.28 150 784496 11239 109793414
Complication of device insertion 23.52 10.28 17 784629 8821 109795832
Cardiac amyloidosis 23.51 10.28 58 784588 2779 109801874
Lacunar stroke 23.46 10.28 24 784622 527 109804126
Coronary artery thrombosis 23.45 10.28 63 784583 3181 109801472
Therapy cessation 23.45 10.28 448 784198 44409 109760244
Diabetic ketosis 23.40 10.28 31 784615 905 109803748
Blood potassium abnormal 23.36 10.28 72 784574 3933 109800720
Drug-disease interaction 23.33 10.28 46 784600 1890 109802763
Product odour abnormal 23.32 10.28 41 784605 1542 109803111
Post viral fatigue syndrome 23.32 10.28 18 784628 268 109804385
Purpura 23.17 10.28 270 784376 24118 109780535
Palmar-plantar erythrodysaesthesia syndrome 23.15 10.28 183 784463 40842 109763811
Iron deficiency anaemia 23.08 10.28 333 784313 31226 109773427
Amputation 23.07 10.28 31 784615 918 109803735
Diastolic dysfunction 23.06 10.28 159 784487 12245 109792408
Paraesthesia oral 22.95 10.28 351 784295 33320 109771333
Skin necrosis 22.95 10.28 77 784569 21435 109783218
Ventricular arrhythmia 22.88 10.28 136 784510 9951 109794702
Aortic stenosis 22.87 10.28 165 784481 12894 109791759
Coronary angioplasty 22.86 10.28 21 784625 402 109804251
Cardiac pacemaker insertion 22.84 10.28 97 784549 6204 109798449
Lichenoid keratosis 22.84 10.28 97 784549 6205 109798448
Tenosynovitis 22.83 10.28 51 784595 16232 109788421
Drug effective for unapproved indication 22.75 10.28 41 784605 14126 109790527
Multiple organ dysfunction syndrome 22.74 10.28 863 783783 150847 109653806
Angiopathy 22.64 10.28 122 784524 8608 109796045
Thrombotic microangiopathy 22.61 10.28 118 784528 29031 109775622
Drug reaction with eosinophilia and systemic symptoms 22.59 10.28 752 783894 81343 109723310
Toe amputation 22.58 10.28 75 784571 4263 109800390
Acquired claw toe 22.48 10.28 10 784636 47 109804606
Glucose urine present 22.47 10.28 50 784596 2239 109802414
Incorrect dosage administered 22.45 10.28 70 784576 3848 109800805
Thrombotic thrombocytopenic purpura 22.41 10.28 105 784541 7006 109797647
Total lung capacity abnormal 22.37 10.28 3 784643 4580 109800073
Mitral valve disease 22.28 10.28 64 784582 3361 109801292
Dilatation atrial 22.23 10.28 69 784577 3783 109800870
Coronary artery surgery 22.23 10.28 14 784632 147 109804506
Drug dependence 22.21 10.28 237 784409 49783 109754870
Anticoagulation drug level increased 22.17 10.28 31 784615 954 109803699
Penis injury 22.13 10.28 13 784633 119 109804534
Renal tubular necrosis 22.07 10.28 321 784325 30154 109774499
Multiple injuries 22.04 10.28 66 784580 3548 109801105
Discoloured vomit 22.02 10.28 46 784600 1971 109802682
Hypocholesterolaemia 21.96 10.28 9 784637 6412 109798241
Flank pain 21.94 10.28 256 784390 22874 109781779
Premature baby 21.84 10.28 4 784642 4851 109799802
Immune effector cell-associated neurotoxicity syndrome 21.81 10.28 45 784601 14737 109789916
Furuncle 21.72 10.28 120 784526 8548 109796105
Peripheral coldness 21.69 10.28 214 784432 18326 109786327
Cardiovascular disorder 21.63 10.28 252 784394 22508 109782145
Non-cardiac chest pain 21.56 10.28 135 784511 10063 109794590
Dry skin 21.51 10.28 952 783694 106701 109697952
Lower urinary tract symptoms 21.47 10.28 22 784624 484 109804169
Diplopia 21.42 10.28 417 784229 41477 109763176
Cerebral ischaemia 21.24 10.28 153 784493 11951 109792702
Leg amputation 21.14 10.28 72 784574 4146 109800507
Abdominal pain upper 21.14 10.28 2161 782485 346950 109457703
Vascular graft occlusion 21.10 10.28 26 784620 705 109803948
Narrow anterior chamber angle 20.94 10.28 14 784632 164 109804489
Lip oedema 20.94 10.28 108 784538 7492 109797161
Aortic valve stenosis 20.93 10.28 95 784551 6255 109798398
Blood creatinine abnormal 20.82 10.28 90 784556 5802 109798851
Creatinine renal clearance decreased 20.69 10.28 82 784564 21733 109782920
Blood lactic acid 20.68 10.28 21 784625 457 109804196
Angiocardiogram 20.50 10.28 17 784629 282 109804371
Device issue 20.46 10.28 152 784494 34383 109770270
Chest wall haematoma 20.45 10.28 22 784624 513 109804140
Brain oedema 20.32 10.28 133 784513 30965 109773688
Stillbirth 20.32 10.28 3 784643 4261 109800392
Pulmonary valve incompetence 20.27 10.28 53 784593 2633 109802020
Injection site warmth 20.18 10.28 60 784586 17345 109787308
Ischaemic limb pain 20.12 10.28 9 784637 43 109804610
Fibromatosis colli of infancy 20.10 10.28 7 784639 14 109804639
Acquired plagiocephaly 20.10 10.28 7 784639 14 109804639
Prolonged expiration 20.08 10.28 38 784608 1514 109803139
Ovarian cyst 20.05 10.28 43 784603 13887 109790766
Hallucination, gustatory 19.99 10.28 10 784636 64 109804589
Injection site pruritus 19.99 10.28 250 784396 51008 109753645
Choking 19.97 10.28 179 784467 14931 109789722
Exposure to toxic agent 19.95 10.28 38 784608 12820 109791833
Cervix neoplasm 19.92 10.28 14 784632 179 109804474
Constipation 19.73 10.28 2861 781785 354925 109449728
Transplant dysfunction 19.69 10.28 18 784628 8310 109796343
Myoglobinuria 19.66 10.28 33 784613 1195 109803458
Neuroleptic malignant syndrome 19.66 10.28 151 784495 33908 109770745
Lecithin-cholesterol acyltransferase deficiency 19.62 10.28 6 784640 6 109804647
Subarachnoid haematoma 19.59 10.28 17 784629 301 109804352
Rash papular 19.57 10.28 290 784356 27349 109777304
Actinic keratosis 19.56 10.28 100 784546 6913 109797740
Dyspnoea paroxysmal nocturnal 19.53 10.28 50 784596 2452 109802201
Anticoagulation drug level abnormal 19.50 10.28 17 784629 303 109804350
Radiculitis brachial 19.50 10.28 10 784636 68 109804585
Needle issue 19.47 10.28 203 784443 17637 109787016
Blood pressure abnormal 19.45 10.28 244 784402 22180 109782473
Nephrotic syndrome 19.40 10.28 166 784480 13665 109790988
Hyperglycaemic hyperosmolar nonketotic syndrome 19.35 10.28 56 784590 2953 109801700
Herpes simplex 19.27 10.28 53 784593 15711 109788942
Radiculopathy 19.24 10.28 216 784430 19120 109785533
Glycogen storage disease type V 19.19 10.28 8 784638 31 109804622
Total cholesterol/HDL ratio increased 19.18 10.28 19 784627 401 109804252
Dissociation 19.15 10.28 25 784621 9817 109794836
Hepatic vein dilatation 19.12 10.28 15 784631 229 109804424
Bundle branch block right 19.11 10.28 151 784495 12140 109792513
Accidental exposure to product 19.09 10.28 245 784401 49763 109754890
Lymphoproliferative disorder 19.06 10.28 14 784632 7204 109797449
BRASH syndrome 19.05 10.28 64 784582 3659 109800994
Cutaneous vasculitis 19.04 10.28 155 784491 12574 109792079
Drug dispensed to wrong patient 19.03 10.28 25 784621 724 109803929
Wound secretion 18.97 10.28 98 784548 6803 109797850
ECG signs of myocardial ischaemia 18.88 10.28 19 784627 409 109804244
Ludwig angina 18.88 10.28 16 784630 274 109804379
Acute pulmonary oedema 18.83 10.28 194 784452 16802 109787851
Traumatic coma 18.80 10.28 10 784636 74 109804579
Hyperthyroidism 18.80 10.28 302 784344 28959 109775694
General symptom 18.77 10.28 21 784625 8825 109795828
Electrocardiogram T wave inversion 18.74 10.28 85 784561 5595 109799058
Blood pressure inadequately controlled 18.68 10.28 105 784541 7528 109797125
Failure to suspend medication 18.61 10.28 20 784626 466 109804187
Oligohydramnios 18.60 10.28 3 784643 3991 109800662
Helicobacter test positive 18.60 10.28 34 784612 1319 109803334
Pancreatitis haemorrhagic 18.58 10.28 29 784617 987 109803666
General physical health deterioration 18.52 10.28 2690 781956 422605 109382048
Wrong patient received product 18.50 10.28 95 784551 6579 109798074
Klebsiella infection 18.48 10.28 76 784570 19933 109784720
Menstruation irregular 18.46 10.28 9 784637 5788 109798865
Consciousness fluctuating 18.31 10.28 45 784601 2151 109802502
Analgesic drug level increased 18.30 10.28 3 784643 3943 109800710
Cerebrovascular disorder 18.29 10.28 63 784583 3648 109801005
Musculoskeletal discomfort 18.27 10.28 251 784395 23287 109781366
Incision site haemorrhage 18.24 10.28 30 784616 1068 109803585
Periorbital haematoma 18.24 10.28 29 784617 1003 109803650
Potassium wasting nephropathy 18.12 10.28 13 784633 172 109804481
Dialysis 18.11 10.28 216 784430 19403 109785250
Dust allergy 18.09 10.28 10 784636 5991 109798662
Change of bowel habit 18.07 10.28 53 784593 2816 109801837
Brain abscess 18.07 10.28 13 784633 6761 109797892
Toxic skin eruption 18.06 10.28 285 784361 27230 109777423
Histoplasmosis disseminated 18 10.28 3 784643 3896 109800757
Loss of proprioception 18.00 10.28 27 784619 887 109803766
Pancreatitis chronic 17.98 10.28 71 784575 4394 109800259
Gastroduodenal haemorrhage 17.95 10.28 16 784630 294 109804359
Myoglobinaemia 17.93 10.28 13 784633 175 109804478
Calcium deficiency 17.92 10.28 31 784615 1151 109803502
Feeling drunk 17.91 10.28 82 784564 5418 109799235
Catatonia 17.88 10.28 33 784613 11267 109793386
Carbuncle 17.85 10.28 35 784611 1432 109803221
Carcinoid tumour of the gastrointestinal tract 17.85 10.28 12 784634 142 109804511
Ventricular dyskinesia 17.77 10.28 19 784627 440 109804213
Joint stiffness 17.77 10.28 353 784293 66890 109737763
Pseudoporphyria 17.67 10.28 25 784621 778 109803875
Epstein-Barr virus associated lymphoproliferative disorder 17.65 10.28 6 784640 4796 109799857
Drug dose omission by device 17.60 10.28 49 784597 14467 109790186
Antineutrophil cytoplasmic antibody positive 17.55 10.28 7 784639 5069 109799584
Blood growth hormone increased 17.50 10.28 29 784617 1039 109803614
Prostatitis 17.48 10.28 74 784572 4727 109799926
Hepatitis 17.47 10.28 794 783852 89260 109715393
Blood parathyroid hormone increased 17.47 10.28 68 784578 4180 109800473
Breast cancer metastatic 17.39 10.28 33 784613 11148 109793505
Burns second degree 17.38 10.28 104 784542 7629 109797024
Rotator cuff syndrome 17.35 10.28 189 784457 16605 109788048
Aneurysm 17.34 10.28 70 784576 4376 109800277
Urinary occult blood positive 17.26 10.28 15 784631 266 109804387
Occupational problem environmental 17.23 10.28 6 784640 12 109804641
Injection site pain 17.19 10.28 1060 783586 176862 109627791
Viral mutation identified 17.17 10.28 5 784641 4414 109800239
Pancreatitis necrotising 17.17 10.28 81 784565 5420 109799233
Vaginal flatulence 17.16 10.28 146 784500 11998 109792655
Ligament sprain 17.14 10.28 182 784464 15886 109788767
Colitis ischaemic 17.08 10.28 197 784449 17553 109787100
Oesophageal carcinoma 17.07 10.28 35 784611 11489 109793164
Epstein-Barr virus infection reactivation 17.06 10.28 4 784642 4080 109800573
Brain natriuretic peptide increased 17.04 10.28 137 784509 11072 109793581
Drug withdrawal syndrome 17.02 10.28 180 784466 37874 109766779
Scleroedema 16.97 10.28 12 784634 155 109804498
Atheroembolism 16.96 10.28 17 784629 364 109804289
Glycosylated haemoglobin abnormal 16.94 10.28 19 784627 465 109804188
Internal haemorrhage 16.93 10.28 126 784520 9945 109794708
Secondary immunodeficiency 16.92 10.28 6 784640 4670 109799983
Testicular swelling 16.89 10.28 37 784609 1639 109803014
Lipid metabolism disorder 16.88 10.28 22 784624 632 109804021
Abnormal weight gain 16.87 10.28 60 784586 3531 109801122
Ventricular dysfunction 16.87 10.28 101 784545 7410 109797243
Nodular rash 16.85 10.28 16 784630 320 109804333
Fibrous histiocytoma 16.83 10.28 25 784621 814 109803839
Tendon pain 16.81 10.28 89 784557 6237 109798416
Aortic arteriosclerosis 16.80 10.28 134 784512 10804 109793849
Tendon disorder 16.78 10.28 109 784537 8228 109796425
Throat clearing 16.73 10.28 68 784578 4265 109800388
Cardioactive drug level increased 16.67 10.28 63 784583 3819 109800834
Muscle relaxant therapy 16.65 10.28 12 784634 160 109804493
Hepatic ischaemia 16.65 10.28 31 784615 1220 109803433
Urine albumin/creatinine ratio increased 16.62 10.28 29 784617 1084 109803569
Sneezing 16.57 10.28 319 784327 31665 109772988
Haemorrhoids 16.56 10.28 350 784296 35322 109769331
Encephalitis toxic 16.50 10.28 15 784631 283 109804370
Benign prostatic hyperplasia 16.50 10.28 200 784446 18034 109786619
Wound haemorrhage 16.46 10.28 72 784574 4666 109799987
Benign gastrointestinal neoplasm 16.44 10.28 11 784635 129 109804524
Hormone-dependent prostate cancer 16.43 10.28 13 784633 201 109804452
Weight fluctuation 16.42 10.28 91 784555 22054 109782599
Face oedema 16.39 10.28 331 784315 33138 109771515
Hip fracture 16.35 10.28 345 784301 34806 109769847
Proctitis 16.35 10.28 188 784458 16739 109787914
Hepatojugular reflux 16.35 10.28 23 784623 712 109803941
Heart valve incompetence 16.35 10.28 64 784582 3945 109800708
Acute respiratory distress syndrome 16.34 10.28 272 784374 52926 109751727
Feeling abnormal 16.33 10.28 1492 783154 179219 109625434
Neuritis 16.33 10.28 17 784629 7382 109797271
Acute myeloid leukaemia recurrent 16.33 10.28 8 784638 5131 109799522
Hepatosplenomegaly 16.31 10.28 15 784631 6904 109797749
Intra-abdominal haematoma 16.30 10.28 58 784588 3414 109801239
Feeling cold 16.28 10.28 335 784311 33652 109771001
Agonal rhythm 16.27 10.28 13 784633 204 109804449
Liver palpable 16.25 10.28 16 784630 335 109804318
Extrapyramidal disorder 16.18 10.28 129 784517 28738 109775915
Spinal epidural haematoma 16.17 10.28 37 784609 1688 109802965
Hyperuricaemia 16.17 10.28 166 784480 14365 109790288
Metabolic function test abnormal 16.16 10.28 22 784624 660 109803993
Penile swelling 16.14 10.28 24 784622 782 109803871
Transplant failure 16.12 10.28 10 784636 5625 109799028
Hyperhidrosis 16.12 10.28 1541 783105 185757 109618896
Maternal exposure during breast feeding 16.10 10.28 5 784641 4233 109800420
Hypertensive heart disease 16.08 10.28 70 784576 4526 109800127
Post stroke epilepsy 16.07 10.28 7 784639 31 109804622
Cerebral microangiopathy 16.06 10.28 17 784629 389 109804264
Electrocardiogram ST segment depression 16.03 10.28 79 784567 5382 109799271
Unintended pregnancy 16.03 10.28 7 784639 4801 109799852
Subchondral insufficiency fracture 16.02 10.28 8 784638 51 109804602
Micturition disorder 16.02 10.28 71 784575 4627 109800026
Oral herpes 16.00 10.28 171 784475 35909 109768744
Spinal stenosis 15.95 10.28 206 784440 18850 109785803
Cardiomegaly 15.94 10.28 293 784353 28837 109775816
Atrial enlargement 15.92 10.28 29 784617 1122 109803531
Cardiac fibrillation 15.91 10.28 28 784618 1054 109803599
Ankylosing spondylitis 15.90 10.28 57 784589 15555 109789098
Maternal exposure during delivery 15.90 10.28 3 784643 3562 109801091
Systemic candida 15.90 10.28 29 784617 9945 109794708
Femoral bruit 15.88 10.28 5 784641 6 109804647
Amaurosis fugax 15.88 10.28 45 784601 2345 109802308
Normocytic anaemia 15.85 10.28 89 784557 6378 109798275
Cystostomy 15.83 10.28 9 784637 77 109804576
Cholestatic pruritus 15.82 10.28 4 784642 0 109804653
Wrong dose 15.80 10.28 48 784598 2601 109802052
Pelvic mass 15.77 10.28 33 784613 1416 109803237
Faeces pale 15.69 10.28 56 784590 3301 109801352
JC virus infection 15.68 10.28 9 784637 5281 109799372
Rhinovirus infection 15.66 10.28 38 784608 11751 109792902
Hypoglobulinaemia 15.66 10.28 13 784633 216 109804437
Intracranial aneurysm 15.58 10.28 74 784572 4966 109799687
Tendonitis 15.57 10.28 266 784380 25817 109778836
Haemorrhage urinary tract 15.50 10.28 51 784595 2885 109801768
Strongyloidiasis 15.48 10.28 8 784638 4978 109799675
Cardiac stress test abnormal 15.48 10.28 24 784622 812 109803841
Blood cholesterol 15.47 10.28 25 784621 877 109803776
High density lipoprotein increased 15.46 10.28 33 784613 1436 109803217
Haemodialysis 15.45 10.28 193 784453 17526 109787127
Body temperature decreased 15.44 10.28 357 784289 36578 109768075
Blood thyroid stimulating hormone increased 15.38 10.28 144 784502 12157 109792496
Eosinophilic granulomatosis with polyangiitis 15.37 10.28 33 784613 10653 109794000
Cerebral artery stenosis 15.36 10.28 25 784621 882 109803771
Vomiting 15.34 10.28 6023 778623 904652 108900001
Dilatation intrahepatic duct acquired 15.33 10.28 24 784622 819 109803834
Pneumonia cytomegaloviral 15.32 10.28 16 784630 6938 109797715
Blood triglycerides decreased 15.27 10.28 13 784633 224 109804429
Impaired work ability 15.26 10.28 268 784378 26151 109778502
Toxic anterior segment syndrome 15.21 10.28 3 784643 3451 109801202
Gastrointestinal vascular malformation haemorrhagic 15.21 10.28 26 784620 956 109803697
Eyelid haematoma 15.19 10.28 10 784636 114 109804539
Sinus congestion 15.18 10.28 302 784344 30157 109774496
Rhinorrhoea 15.17 10.28 882 783764 101784 109702869
Lung opacity 15.14 10.28 38 784608 11614 109793039
Wound complication 15.13 10.28 85 784561 6092 109798561
Memory impairment 15.13 10.28 1197 783449 195747 109608906
Neuroglycopenia 15.11 10.28 28 784618 1098 109803555
Implantable defibrillator insertion 15.07 10.28 29 784617 1170 109803483
Laryngeal haematoma 15.04 10.28 12 784634 188 109804465
Cardiac operation 15.02 10.28 83 784563 5912 109798741
Bezoar 15.02 10.28 5 784641 4049 109800604
Arteriovenous fistula occlusion 15.00 10.28 19 784627 530 109804123
Angioplasty 14.98 10.28 39 784607 1932 109802721
Skin laceration 14.97 10.28 329 784317 33424 109771229
Muscle strain 14.96 10.28 133 784513 11069 109793584
Vertebral artery stenosis 14.94 10.28 13 784633 231 109804422
Paresis 14.88 10.28 71 784575 4773 109799880
Peripheral circulatory failure 14.88 10.28 37 784609 1782 109802871
Cerebral artery occlusion 14.87 10.28 39 784607 1941 109802712
Prostate cancer metastatic 14.86 10.28 72 784574 4871 109799782
Aortic valve disease 14.86 10.28 42 784604 2185 109802468
Drug specific antibody present 14.85 10.28 23 784623 8411 109796242
Facial paralysis 14.84 10.28 248 784398 23966 109780687
Carotid bruit 14.84 10.28 22 784624 715 109803938
Pelvic cyst 14.84 10.28 8 784638 61 109804592
Heart sounds 14.81 10.28 28 784618 1115 109803538
Vitamin B12 deficiency 14.80 10.28 122 784524 9933 109794720
Prothrombin consumption time prolonged 14.79 10.28 7 784639 39 109804614
Blood chloride decreased 14.73 10.28 113 784533 9002 109795651
Respiratory tract congestion 14.73 10.28 304 784342 30553 109774100
Product administration error 14.72 10.28 357 784289 36860 109767793
Quadrantanopia 14.71 10.28 13 784633 236 109804417
Hypercatabolism 14.69 10.28 5 784641 9 109804644
Intercepted product preparation error 14.68 10.28 16 784630 6804 109797849
Chronic left ventricular failure 14.67 10.28 30 784616 1266 109803387
Nail avulsion 14.64 10.28 11 784635 157 109804496
Ocular icterus 14.64 10.28 83 784563 5970 109798683
Blood testosterone decreased 14.61 10.28 49 784597 2799 109801854
Faecaloma 14.59 10.28 166 784480 14742 109789911
Hepatorenal syndrome 14.58 10.28 68 784578 4529 109800124
Staphylococcal infection 14.57 10.28 381 784265 69563 109735090
Nuchal rigidity 14.52 10.28 29 784617 1203 109803450
Electrocardiogram ST-T change 14.51 10.28 34 784612 1576 109803077
Device deployment issue 14.48 10.28 6 784640 4247 109800406
Burning feet syndrome 14.45 10.28 13 784633 242 109804411
Idiopathic intracranial hypertension 14.42 10.28 5 784641 3947 109800706
Acne 14.41 10.28 160 784486 33360 109771293
Sprue-like enteropathy 14.40 10.28 35 784611 1661 109802992
Vitreous haemorrhage 14.40 10.28 68 784578 4552 109800101
Conduction disorder 14.37 10.28 62 784584 3993 109800660
Obstructive pancreatitis 14.37 10.28 29 784617 1212 109803441
Basilar artery stenosis 14.37 10.28 7 784639 42 109804611
Xyphoid retraction 14.35 10.28 11 784635 162 109804491
Bronchial irritation 14.32 10.28 8 784638 66 109804587
Thirst 14.31 10.28 225 784421 21482 109783171
Pulmonary alveolar haemorrhage 14.30 10.28 84 784562 20066 109784587
Device related sepsis 14.30 10.28 20 784626 7627 109797026
Compartment syndrome 14.26 10.28 81 784565 5829 109798824
Haemarthrosis 14.25 10.28 95 784551 7234 109797419
Wound haematoma 14.24 10.28 11 784635 164 109804489
Cardiac septal hypertrophy 14.22 10.28 16 784630 393 109804260
Abdominal hernia 14.16 10.28 88 784558 6541 109798112
Disturbance in attention 14.15 10.28 556 784090 61439 109743214
Fear of injection 14.12 10.28 26 784620 8885 109795768
Optic discs blurred 14.12 10.28 8 784638 68 109804585
Percutaneous coronary intervention 14.11 10.28 17 784629 450 109804203
Nasal obstruction 14.08 10.28 54 784592 3296 109801357
High density lipoprotein abnormal 14.04 10.28 12 784634 208 109804445
Loss of control of legs 14.02 10.28 40 784606 2092 109802561
Leukocyturia 14.02 10.28 42 784604 2258 109802395
Sacroiliitis 14.02 10.28 9 784637 4969 109799684
Intracranial mass 13.99 10.28 43 784603 2345 109802308
Cervicobrachial syndrome 13.98 10.28 28 784618 1164 109803489
Bulbar palsy 13.94 10.28 15 784631 350 109804303
Autoimmune myocarditis 13.93 10.28 20 784626 631 109804022
Carotid endarterectomy 13.91 10.28 11 784635 170 109804483
Brain stem stroke 13.88 10.28 22 784624 759 109803894
Collagen disorder 13.85 10.28 14 784632 303 109804350
Drop attacks 13.84 10.28 27 784619 1101 109803552
International normalised ratio decreased 13.82 10.28 103 784543 8133 109796520
Choluria 13.74 10.28 17 784629 463 109804190
Systemic mycosis 13.71 10.28 5 784641 3824 109800829
Poisoning deliberate 13.71 10.28 120 784526 26211 109778442
Scrotal swelling 13.67 10.28 28 784618 1183 109803470
Tobacco abuse 13.67 10.28 26 784620 1040 109803613
Nephropathy 13.65 10.28 151 784495 13316 109791337
Sarcopenia 13.62 10.28 28 784618 1186 109803467
Accidental exposure to product by child 13.62 10.28 3 784643 3195 109801458
Vascular dementia 13.61 10.28 24 784622 905 109803748
Internal carotid artery deformity 13.61 10.28 4 784642 3 109804650
Post stroke seizure 13.61 10.28 4 784642 3 109804650
Platelet aggregation test 13.60 10.28 7 784639 48 109804605
Iliac artery stenosis 13.57 10.28 12 784634 218 109804435
Muscle oedema 13.57 10.28 13 784633 263 109804390
Accelerated hypertension 13.54 10.28 22 784624 775 109803878
Acidosis 13.53 10.28 230 784416 22301 109782352
Alpha hydroxybutyrate dehydrogenase increased 13.52 10.28 6 784640 28 109804625
Peripheral paralysis 13.49 10.28 11 784635 178 109804475
Forced expiratory volume decreased 13.49 10.28 48 784598 13128 109791525
Blood calcitonin increased 13.48 10.28 7 784639 49 109804604
Stenotrophomonas infection 13.45 10.28 13 784633 5845 109798808
Hyperphosphataemia 13.45 10.28 65 784581 16316 109788337
Bladder neoplasm 13.42 10.28 37 784609 1897 109802756
Heat stroke 13.41 10.28 37 784609 1898 109802755
Tobacco interaction 13.41 10.28 10 784636 141 109804512
Labyrinthitis 13.40 10.28 50 784596 3012 109801641
Vitamin D abnormal 13.40 10.28 12 784634 222 109804431
Lens dislocation 13.39 10.28 11 784635 180 109804473
Albuminuria 13.39 10.28 25 784621 986 109803667
Cholangiocarcinoma 13.38 10.28 48 784598 2837 109801816
Renal pain 13.34 10.28 117 784529 9700 109794953
Pulmonary tuberculosis 13.33 10.28 28 784618 9111 109795542
Immobile 13.31 10.28 97 784549 7605 109797048
Entropion 13.28 10.28 9 784637 108 109804545
Parainfluenzae virus infection 13.28 10.28 18 784628 6956 109797697
Staphylococcal bacteraemia 13.26 10.28 67 784579 16621 109788032
Colorectal cancer 13.23 10.28 28 784618 9086 109795567
Inclusion body myositis 13.20 10.28 8 784638 78 109804575
COVID-19 13.19 10.28 1957 782689 243103 109561550
Nerve degeneration 13.17 10.28 13 784633 273 109804380
Lipids abnormal 13.15 10.28 20 784626 665 109803988
Product dose omission issue 13.14 10.28 2532 782114 319250 109485403
Product administered to patient of inappropriate age 13.14 10.28 23 784623 8013 109796640
Spontaneous haematoma 13.10 10.28 37 784609 1924 109802729
Electrocardiogram T wave abnormal 13.09 10.28 62 784584 4155 109800498
Blue toe syndrome 13.09 10.28 20 784626 668 109803985
Conjunctivitis allergic 13.09 10.28 18 784628 6913 109797740
Malaise 13.08 10.28 5123 779523 666696 109137957
Copper metabolism disorder 13.08 10.28 4 784642 4 109804649
Anti-SRP antibody positive 13.08 10.28 4 784642 4 109804649
Brain stem infarction 13.04 10.28 39 784607 2095 109802558
Penile discharge 13.03 10.28 7 784639 53 109804600
Urine flow decreased 13.01 10.28 30 784616 1376 109803277
Supraventricular extrasystoles 13.00 10.28 100 784546 7973 109796680
Acute lymphocytic leukaemia 13.00 10.28 13 784633 5752 109798901
Mammogram abnormal 12.97 10.28 18 784628 550 109804103
Peripheral nerve palsy 12.95 10.28 8 784638 81 109804572
Coronary arterial stent insertion 12.94 10.28 79 784567 5836 109798817
Hyperlipasaemia 12.94 10.28 31 784615 1458 109803195
Headache 12.94 10.28 5864 778782 876513 108928140
Electrocardiogram ST segment elevation 12.88 10.28 110 784536 9050 109795603
Interstitial granulomatous dermatitis 12.87 10.28 13 784633 281 109804372
Vascular graft complication 12.80 10.28 11 784635 192 109804461
Diabetic complication 12.78 10.28 30 784616 1392 109803261
Blood phosphorus increased 12.75 10.28 66 784580 16274 109788379
Paraesthesia 12.73 10.28 1743 782903 274778 109529875
Flushing 12.72 10.28 610 784036 104126 109700527
Cough decreased 12.72 10.28 5 784641 16 109804637
Phimosis 12.71 10.28 22 784624 817 109803836
Pharyngeal swelling 12.70 10.28 136 784510 11896 109792757
Urinary hesitation 12.70 10.28 66 784580 4592 109800061
Cardiac discomfort 12.70 10.28 30 784616 1398 109803255
Patella fracture 12.68 10.28 42 784604 2384 109802269
Brain stem haematoma 12.67 10.28 10 784636 154 109804499
Haemangioma of liver 12.67 10.28 30 784616 1400 109803253
Metabolic encephalopathy 12.62 10.28 127 784519 10933 109793720
Paroxysmal arrhythmia 12.60 10.28 7 784639 57 109804596
Nephrogenic anaemia 12.58 10.28 65 784581 4512 109800141
Virologic failure 12.57 10.28 10 784636 4942 109799711
Renal haemorrhage 12.56 10.28 43 784603 2482 109802171
Product coating issue 12.55 10.28 9 784637 119 109804534
Alanine aminotransferase 12.51 10.28 12 784634 243 109804410
Blood alkaline phosphatase abnormal 12.51 10.28 28 784618 1259 109803394
Benign pancreatic neoplasm 12.50 10.28 7 784639 58 109804595
Eczema 12.46 10.28 630 784016 71663 109732990
Tendon injury 12.45 10.28 42 784604 2407 109802246
Neurosensory hypoacusis 12.43 10.28 12 784634 245 109804408
Sebaceous gland infection 12.41 10.28 10 784636 159 109804494
Bone cyst 12.41 10.28 5 784641 3598 109801055
Hemianaesthesia 12.40 10.28 16 784630 455 109804198
Nail bed bleeding 12.39 10.28 22 784624 834 109803819
Biopsy colon abnormal 12.39 10.28 8 784638 88 109804565
Mean cell haemoglobin concentration abnormal 12.35 10.28 11 784635 202 109804451
Prevertebral soft tissue swelling of cervical space 12.31 10.28 6 784640 36 109804617
Post procedural haemorrhage 12.28 10.28 166 784480 15346 109789307
Hypoaesthesia oral 12.28 10.28 179 784467 16823 109787830
Peripheral sensorimotor neuropathy 12.26 10.28 58 784588 3885 109800768
Hypotonia 12.26 10.28 168 784478 15577 109789076
Anticoagulation drug level above therapeutic 12.21 10.28 65 784581 4565 109800088
Winged scapula 12.20 10.28 4 784642 6 109804647
Craniocerebral injury 12.20 10.28 78 784568 5856 109798797
Sinoatrial block 12.19 10.28 30 784616 1435 109803218
Libido decreased 12.19 10.28 78 784568 5857 109798796
Injection site haemorrhage 12.17 10.28 163 784483 32865 109771788
Decreased gait velocity 12.17 10.28 11 784635 206 109804447
Coronary ostial stenosis 12.15 10.28 10 784636 164 109804489
Arterial disorder 12.12 10.28 39 784607 2180 109802473
Thalamus haemorrhage 12.10 10.28 36 784610 1928 109802725
Glycosylated haemoglobin decreased 12.10 10.28 22 784624 850 109803803
Polyomavirus-associated nephropathy 12.07 10.28 25 784621 8176 109796477
Waist circumference increased 12.05 10.28 34 784612 1767 109802886
Prostatic operation 12.03 10.28 14 784632 357 109804296
Postrenal failure 12.02 10.28 22 784624 854 109803799
Blood osmolarity decreased 12.02 10.28 30 784616 1448 109803205
Aortic aneurysm rupture 12.00 10.28 29 784617 1371 109803282
Lipids increased 12.00 10.28 36 784610 1937 109802716
Right ventricular enlargement 11.99 10.28 24 784622 997 109803656
Hepatitis B 11.99 10.28 32 784614 9580 109795073
Mitral valve stenosis 11.98 10.28 29 784617 1373 109803280
Pseudomonas infection 11.96 10.28 133 784513 27720 109776933
Pharyngitis streptococcal 11.91 10.28 51 784595 13226 109791427
Cystitis 11.90 10.28 578 784068 65458 109739195
Nicotine dependence 11.88 10.28 28 784618 1303 109803350
Left atrial volume increased 11.88 10.28 8 784638 95 109804558
Wrong dosage form 11.87 10.28 3 784643 0 109804653
Progressive muscular atrophy 11.87 10.28 3 784643 0 109804653
Foreign travel 11.87 10.28 3 784643 0 109804653
Red blood cell acanthocytes present 11.87 10.28 3 784643 0 109804653
Fibrous cortical defect 11.87 10.28 3 784643 0 109804653
Leukocyte alkaline phosphatase increased 11.87 10.28 3 784643 0 109804653
Metastases to bone 11.86 10.28 154 784492 31218 109773435
Prostatic disorder 11.85 10.28 42 784604 2467 109802186
Oesophageal adenocarcinoma stage 0 11.83 10.28 4 784642 7 109804646
False positive investigation result 11.82 10.28 29 784617 1385 109803268
Application site dermatitis 11.81 10.28 10 784636 171 109804482
Hypertensive angiopathy 11.81 10.28 8 784638 96 109804557
Tic 11.78 10.28 5 784641 3488 109801165
Tension headache 11.73 10.28 112 784534 9506 109795147
Uveitis 11.72 10.28 98 784548 21612 109783041
Plasmacytoma 11.72 10.28 12 784634 5250 109799403
Bronchial secretion retention 11.71 10.28 11 784635 5013 109799640
Left ventricular dilatation 11.71 10.28 29 784617 1393 109803260
Renal mass 11.70 10.28 54 784592 3581 109801072
Atrial pressure increased 11.67 10.28 8 784638 98 109804555
Antipsychotic drug level above therapeutic 11.66 10.28 41 784605 2399 109802254
Lateral medullary syndrome 11.66 10.28 7 784639 67 109804586
Retroperitoneal fibrosis 11.61 10.28 20 784626 740 109803913
Smooth muscle antibody positive 11.57 10.28 10 784636 176 109804477
Thrombosis in device 11.56 10.28 71 784575 5256 109799397
Hypoperfusion 11.56 10.28 49 784597 3132 109801521
Meningorrhagia 11.55 10.28 14 784632 373 109804280
Rash vesicular 11.54 10.28 59 784587 14593 109790060
Device use error 11.53 10.28 30 784616 9059 109795594
Hyperprolactinaemia 11.51 10.28 18 784628 6557 109798096
Sinus arrest 11.49 10.28 60 784586 4182 109800471
Pulmonary haemorrhage 11.47 10.28 69 784577 16387 109788266
Anion gap increased 11.47 10.28 61 784585 4283 109800370
Cystic fibrosis 11.46 10.28 10 784636 4721 109799932
Hormone-refractory prostate cancer 11.43 10.28 22 784624 888 109803765
Cardiac arrest 11.40 10.28 1578 783068 195175 109609478
Haemoglobin increased 11.40 10.28 107 784539 9040 109795613
Essential tremor 11.40 10.28 34 784612 1824 109802829
Subclavian artery stenosis 11.39 10.28 12 784634 273 109804380
Device malfunction 11.39 10.28 121 784525 25437 109779216
Cutaneous lupus erythematosus 11.36 10.28 52 784594 3436 109801217
Orchitis 11.35 10.28 34 784612 1828 109802825
Arcus lipoides 11.33 10.28 5 784641 23 109804630
Antidepressant drug level below therapeutic 11.33 10.28 5 784641 23 109804630
Endocrine ophthalmopathy 11.30 10.28 28 784618 1345 109803308
Jugular vein distension 11.30 10.28 31 784615 1585 109803068
Influenza like illness 11.30 10.28 750 783896 87662 109716991
Oedema genital 11.29 10.28 18 784628 624 109804029
Nephrostomy 11.25 10.28 13 784633 329 109804324
Dermatitis acneiform 11.24 10.28 49 784597 12646 109792007
NYHA classification 11.21 10.28 6 784640 45 109804608
Blood lactic acid increased 11.20 10.28 166 784480 15655 109788998
Ulcer 11.19 10.28 227 784419 42889 109761764
Vocal cord polypectomy 11.17 10.28 4 784642 9 109804644
Linear IgA disease 11.16 10.28 61 784585 4328 109800325
Liver transplant rejection 11.15 10.28 7 784639 3911 109800742
Granuloma annulare 11.14 10.28 21 784625 834 109803819
Renal neoplasm 11.13 10.28 40 784606 2366 109802287
Large intestinal haemorrhage 11.13 10.28 48 784598 3091 109801562
Left ventricular end-diastolic pressure increased 11.10 10.28 19 784627 699 109803954
Hepatic enzyme abnormal 11.09 10.28 112 784534 9651 109795002
Vaginal haemorrhage 11.05 10.28 119 784527 24955 109779698
Sepsis 11.05 10.28 2100 782546 325246 109479407
Defect conduction intraventricular 11.05 10.28 19 784627 702 109803951
Hypoalbuminaemia 11.04 10.28 142 784504 28832 109775821
Colonoscopy abnormal 11.03 10.28 10 784636 188 109804465
Antimitochondrial antibody positive 11.02 10.28 8 784638 108 109804545
Haemorrhagic cyst 11.02 10.28 14 784632 392 109804261
Gingival bleeding 11.01 10.28 200 784446 19639 109785014
Coronary artery embolism 11.00 10.28 13 784633 337 109804316
Laryngotracheal oedema 11.00 10.28 6 784640 47 109804606
Transient global amnesia 10.99 10.28 24 784622 1061 109803592
Systolic dysfunction 10.98 10.28 61 784585 4354 109800299
Mallory-Weiss syndrome 10.95 10.28 48 784598 3113 109801540
Bilirubin conjugated abnormal 10.95 10.28 10 784636 190 109804463
Pancreatic cyst 10.94 10.28 44 784602 2746 109801907
Micturition frequency decreased 10.94 10.28 23 784623 990 109803663
Acquired gene mutation 10.92 10.28 3 784643 2751 109801902
Lymph node calcification 10.92 10.28 15 784631 454 109804199
Pancreatic carcinoma 10.91 10.28 157 784489 14715 109789938
Hysterectomy 10.90 10.28 26 784620 8088 109796565
Aortic valve sclerosis 10.90 10.28 34 784612 1869 109802784
Left ventricular false tendon 10.89 10.28 6 784640 48 109804605
Pleuroperitoneal communication 10.88 10.28 4 784642 10 109804643
Adenocarcinoma gastric 10.87 10.28 36 784610 2043 109802610
Decreased appetite 10.86 10.28 3650 780996 472196 109332457
Psychiatric decompensation 10.86 10.28 15 784631 5750 109798903
Microalbuminuria 10.85 10.28 26 784620 1223 109803430
Metastases to liver 10.84 10.28 181 784465 35205 109769448
Retroperitoneal haemorrhage 10.84 10.28 77 784569 5988 109798665
Parosmia 10.83 10.28 142 784504 13038 109791615
Halo vision 10.82 10.28 18 784628 647 109804006
Device leakage 10.81 10.28 68 784578 15980 109788673
Skin oedema 10.80 10.28 35 784611 1964 109802689
Mean cell haemoglobin concentration 10.79 10.28 6 784640 49 109804604
Diaphragm muscle weakness 10.78 10.28 10 784636 194 109804459
Basosquamous carcinoma 10.77 10.28 8 784638 112 109804541
Vascular access site occlusion 10.77 10.28 8 784638 112 109804541
Ventricle rupture 10.77 10.28 8 784638 112 109804541
Blood cholinesterase decreased 10.74 10.28 15 784631 461 109804192
Ischaemia 10.70 10.28 105 784541 8978 109795675
Schizophrenia 10.69 10.28 101 784545 21725 109782928
Angiodysplasia 10.69 10.28 29 784617 1473 109803180
Anaphylactic reaction 10.69 10.28 683 783963 113617 109691036
Cerebellar syndrome 10.68 10.28 79 784567 6223 109798430
Sitting disability 10.67 10.28 15 784631 464 109804189
Hypersensitivity vasculitis 10.66 10.28 85 784561 6852 109797801
Urine abnormality 10.64 10.28 105 784541 8991 109795662
Encephalitis viral 10.64 10.28 4 784642 3003 109801650
Subcapsular splenic haematoma 10.62 10.28 7 784639 80 109804573
Varicella zoster virus infection 10.62 10.28 18 784628 6350 109798303
Pseudohyponatraemia 10.61 10.28 10 784636 198 109804455
Paratracheal lymphadenopathy 10.61 10.28 10 784636 198 109804455
Restless legs syndrome 10.60 10.28 239 784407 24387 109780266
Exfoliative rash 10.59 10.28 62 784584 4512 109800141
Urinary straining 10.59 10.28 6 784640 51 109804602
Hypomania 10.58 10.28 37 784609 10173 109794480
Blood ketone body increased 10.58 10.28 21 784625 867 109803786
Hypertensive nephropathy 10.56 10.28 23 784623 1015 109803638
Rheumatoid lung 10.54 10.28 9 784637 4295 109800358
Noninfectious peritonitis 10.53 10.28 12 784634 299 109804354
Hepatic haematoma 10.53 10.28 22 784624 943 109803710
Ketonuria 10.51 10.28 28 784618 1407 109803246
Primary hypoparathyroidism 10.49 10.28 6 784640 52 109804601
Gastrointestinal polyp 10.49 10.28 10 784636 201 109804452
Fracture 10.49 10.28 240 784406 24548 109780105
Gastrooesophageal reflux disease 10.48 10.28 1117 783529 178859 109625794
Peripheral embolism 10.43 10.28 35 784611 2000 109802653
Aspiration 10.43 10.28 153 784493 30380 109774273
Vitreous detachment 10.43 10.28 42 784604 2623 109802030
Embedded device 10.42 10.28 8 784638 4025 109800628
Thrombocytopenic purpura 10.42 10.28 46 784600 2993 109801660
Extra dose administered 10.41 10.28 132 784514 12027 109792626
Eye irritation 10.41 10.28 311 784335 33141 109771512
Decreased interest 10.39 10.28 65 784581 4843 109799810
Blood uric acid increased 10.39 10.28 100 784546 21429 109783224
Neutropenic infection 10.39 10.28 5 784641 3240 109801413
Ichthyosis 10.37 10.28 10 784636 204 109804449
Crying 10.37 10.28 124 784522 25504 109779149
Slipping rib syndrome 10.36 10.28 4 784642 12 109804641
Spinal osteoarthritis 10.35 10.28 201 784445 19982 109784671
Chronic sinusitis 10.34 10.28 242 784404 24842 109779811
Death 10.33 10.28 5281 779365 693588 109111065
Saliva altered 10.30 10.28 16 784630 542 109804111
Malnutrition 10.29 10.28 260 784386 27019 109777634
Atrial tachycardia 10.28 10.28 105 784541 9073 109795580

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C10AA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, PLAIN
HMG CoA reductase inhibitors
ATC C10BA05 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BA16 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Combinations of various lipid modifying agents
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX06 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX08 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX12 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX15 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX19 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA MoA N0000000121 Hydroxymethylglutaryl-CoA Reductase Inhibitors
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminant
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019161 Hydroxymethylglutaryl-CoA Reductase Inhibitors
MeSH PA D057847 Lipid Regulating Agents
FDA EPC N0000175589 HMG-CoA Reductase Inhibitor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35821 anticholesteremic drug
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:36335 trypanocidal drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50748 antipsoriatic
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:63726 neuroprotective agent

Related Drugs by ATC class:

C10AA HMG CoA reductase inhibitors 7 drugs
cerivastatinfluvastatinlovastatinpitavastatinpravastatinrosuvastatinsimvastatin
C10BA Combinations of various lipid modifying agents 9 drugs
bempedoic acidezetimibefenofibratelovastatinnicotinic acidpitavastatinpravastatinrosuvastatinsimvastatin
C10BX Lipid modifying agents in combination with other drugs 14 drugs
acetylsalicylic acidamlodipinecandesartan cilexetilfimasartanindapamidelisinoprilnebivololperindoprilpravastatinramiprilrosuvastatinsimvastatin show all 14 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypercholesterolemia indication 13644009
Arteriosclerotic vascular disease indication 72092001
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Familial hypercholesterolemia - homozygous indication 238078005
Familial hypercholesterolemia - heterozygous indication 238079002
Mixed hyperlipidemia indication 267434003
Hypertriglyceridemia indication 302870006
Familial type 3 hyperlipoproteinemia indication 398796005 DOID:3145
Slow Progression of Coronary Artery Disease indication
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Prevention of Transient Ischemic Attacks off-label use
Alcoholism contraindication 7200002
Hypothyroidism contraindication 40930008 DOID:1459
Low blood pressure contraindication 45007003
Hepatic failure contraindication 59927004
Chronic idiopathic constipation contraindication 82934008
Kidney disease contraindication 90708001 DOID:557
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Pregnancy, function contraindication 289908002
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Severe Aortic Valve Stenosis contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.44 acidic
pKa2 11.82 acidic
pKa3 13.63 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
20MG/5ML ATORVALIQ CMP DEV LLC N213260 Feb. 1, 2023 RX SUSPENSION ORAL 11654106 June 7, 2037 AS AN ADJUNCT TO DIET TO REDUCE LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN ADULTS AND PEDIATRIC PATIENTS AGED 10 YEARS AND OLDER WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA
20MG/5ML ATORVALIQ CMP DEV LLC N213260 Feb. 1, 2023 RX SUSPENSION ORAL 11654106 June 7, 2037 AS AN ADJUNCT TO OTHER LOW-DENSITY LIPOPROTEIN CHOLESTEROL (LDL-C) LOWERING THERAPIES, OR ALONE IF SUCH TREATMENTS ARE UNAVAILABLE, TO REDUCE LDL-C IN ADULTS AND PEDIATRIC PATIENTS AGED 10 YEARS AND OLDER WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA
20MG/5ML ATORVALIQ CMP DEV LLC N213260 Feb. 1, 2023 RX SUSPENSION ORAL 11925704 June 7, 2037 METHOD FOR LOWERING CHOLESTEROL LEVEL IN A HUMAN

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme INHIBITOR IC50 8 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme IC50 5.29 CHEMBL
ATP-binding cassette sub-family G member 2 Transporter IC50 5.37 CHEMBL
Histone deacetylase 2 Enzyme IC50 4.65 CHEMBL
Histone deacetylase 1 Enzyme IC50 4.93 CHEMBL
Histone deacetylase 6 Enzyme IC50 4.84 CHEMBL
Nuclear receptor subfamily 1 group I member 3 Nuclear hormone receptor WOMBAT-PK
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 8.42 CHEMBL
3-hydroxy-3-methylglutaryl-coenzyme A reductase Enzyme IC50 4.49 CHEMBL

External reference:

IDSource
4024041 VUID
N0000022046 NUI
D00887 KEGG_DRUG
134523-03-8 SECONDARY_CAS_RN
344423-98-9 SECONDARY_CAS_RN
1297766 RXNORM
C0286651 UMLSCUI
CHEBI:39548 CHEBI
117 PDB_CHEM_ID
CHEMBL1487 ChEMBL_ID
CHEMBL393220 ChEMBL_ID
D000069059 MESH_DESCRIPTOR_UI
DB01076 DRUGBANK_ID
2949 IUPHAR_LIGAND_ID
7259 INN_ID
A0JWA85V8F UNII
60823 PUBCHEM_CID
186242 MMSL
34584 MMSL
34879 MMSL
4226 MMSL
d04105 MMSL
4020999 VANDF
4024041 VANDF
006321 NDDF
006322 NDDF
108600003 SNOMEDCT_US
108601004 SNOMEDCT_US
1268949007 SNOMEDCT_US
373444002 SNOMEDCT_US
725658002 SNOMEDCT_US
A0JWA85V8F INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 20 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 20 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 40 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 40 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 80 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 80 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6180 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6323 TABLET, FILM COATED 20 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6565 TABLET, FILM COATED 40 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-6747 TABLET, FILM COATED 80 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7232 TABLET, FILM COATED 20 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7476 TABLET, FILM COATED 80 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7654 TABLET, FILM COATED 40 mg ORAL NDA 29 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-7810 TABLET, FILM COATED 10 mg ORAL NDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5056 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5057 TABLET, FILM COATED 80 mg ORAL ANDA 26 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5058 TABLET, FILM COATED 40 mg ORAL ANDA 26 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0093-5059 TABLET, FILM COATED 20 mg ORAL ANDA 26 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3950 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3951 TABLET, FILM COATED 20 mg ORAL ANDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3952 TABLET, FILM COATED 40 mg ORAL ANDA 29 sections
Atorvastatin Calcium HUMAN PRESCRIPTION DRUG LABEL 1 0378-3953 TABLET, FILM COATED 80 mg ORAL ANDA 29 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4513 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4514 TABLET, FILM COATED 20 mg ORAL ANDA 28 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4515 TABLET, FILM COATED 40 mg ORAL ANDA 28 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4516 TABLET, FILM COATED 80 mg ORAL ANDA 28 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4517 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Amlodipine and atorvastatin HUMAN PRESCRIPTION DRUG LABEL 2 0378-4518 TABLET, FILM COATED 20 mg ORAL ANDA 28 sections