All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

pseudoephedrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
sympathomimetics	2326	90-82-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: pseudoephedrine (+)-Pseudoephedrine pseudophedrine sulphate pseudoephedrine hydrochloride pseudoephedrine sulfate pseudoephedrine HCl pseudoephedrine polistirex	A phenethylamine that is an isomer of EPHEDRINE which has less central nervous system effects and usage is mainly for respiratory tract decongestion. Molecular weight: 165.24 Formula: C10H15NO CLOGP: 0.89 LIPINSKI: 0 HAC: 2 HDO: 2 TPSA: 32.26 ALOGS: -1.30 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.24	g	O
0.24	g	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	43 %	Benet LZ, Broccatelli F, Oprea TI

Approvals:

Date	Agency	Company	Orphan
Oct. 18, 1963	FDA	SCHERING PLOUGH

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	2711.06	22.98	1905	77373	118261	50407585
Systemic lupus erythematosus	2523.93	22.98	1942	77336	138680	50387166
Pericarditis	2285.91	22.98	1461	77817	77228	50448618
Glossodynia	2282.76	22.98	1691	77587	113878	50411968
Hand deformity	2224.29	22.98	1574	77704	98625	50427221
Wound	2186.04	22.98	1591	77687	104203	50421643
Anti-cyclic citrullinated peptide antibody positive	1951.66	22.98	1271	78007	69316	50456530
Discomfort	1944.65	22.98	1498	77780	106882	50418964
Abdominal discomfort	1743.71	22.98	1971	77307	229670	50296176
Synovitis	1629.94	22.98	1430	77848	122435	50403411
Alopecia	1623.67	22.98	1953	77325	243094	50282752
Arthropathy	1591.61	22.98	1571	77707	156335	50369511
Swelling	1450.37	22.98	1674	77604	199198	50326648
Maternal exposure during pregnancy	1361.89	22.98	1453	77825	158325	50367521
Hepatic enzyme increased	1320.92	22.98	1333	77945	136047	50389799
Duodenal ulcer perforation	1305.25	22.98	840	78438	44771	50481075
Contraindicated product administered	1253.85	22.98	1346	77932	147612	50378234
Helicobacter infection	1246.61	22.98	843	78435	48859	50476987
Infusion related reaction	1224.34	22.98	1414	77864	168143	50357703
Rheumatoid factor positive	1070.82	22.98	769	78509	49090	50476756
Hypersensitivity	1058.04	22.98	1482	77796	213679	50312167
Drug intolerance	873.40	22.98	1368	77910	217736	50308110
Product use issue	865.71	22.98	1116	78162	148359	50377487
Joint swelling	804.81	22.98	1403	77875	243883	50281963
Therapeutic product effect decreased	662.46	22.98	934	78344	135116	50390730
Blister	614.12	22.98	712	78566	84706	50441140
Treatment failure	594.54	22.98	893	78385	136744	50389102
Muscle injury	573.57	22.98	471	78807	36640	50489206
Pain	570.78	22.98	2090	77188	576813	49949033
Folliculitis	565.11	22.98	478	78800	38747	50487099
Sleep disorder due to general medical condition, insomnia type	556.16	22.98	432	78846	31015	50494831
Irritable bowel syndrome	555.81	22.98	533	78745	50908	50474938
Rheumatic fever	550.52	22.98	338	78940	16529	50509317
Swollen joint count increased	516.14	22.98	310	78968	14563	50511283
Rheumatoid arthritis	508.04	22.98	1034	78244	201516	50324330
Rash	459.33	22.98	1614	77664	435857	50089989
Type 2 diabetes mellitus	367.02	22.98	354	78924	34021	50491825
Diarrhoea	348.53	22.98	250	79028	588226	49937620
Fall	342.56	22.98	57	79221	334875	50190971
Impaired healing	338.85	22.98	479	78799	69307	50456539
Nausea	337.00	22.98	367	78911	705031	49820815
Death	333.59	22.98	55	79223	325324	50200522
Hip arthroplasty	298.08	22.98	299	78979	30130	50495716
Anaemia	296.88	22.98	27	79251	252429	50273417
Blood cholesterol increased	292.01	22.98	395	78883	54820	50471026
Acute kidney injury	274.66	22.98	22	79256	228036	50297810
Stomatitis	251.77	22.98	516	78762	100828	50425018
Hypotension	249.82	22.98	36	79242	235433	50290413
Lower respiratory tract infection	230.90	22.98	480	78798	94721	50431125
Knee arthroplasty	227.95	22.98	281	78997	35565	50490281
Gastrointestinal disorder	224.13	22.98	472	78806	93984	50431862
Ill-defined disorder	223.24	22.98	346	78932	54308	50471538
Musculoskeletal stiffness	214.09	22.98	559	78719	127922	50397924
General physical health deterioration	202.80	22.98	585	78693	141849	50383997
Drug interaction	201.57	22.98	35	79243	199586	50326260
Pneumonia	198.15	22.98	181	79097	378220	50147626
Drug ineffective	192.39	22.98	2040	77238	817293	49708553
Asthenia	191.59	22.98	133	79145	318909	50206937
Cough	188.84	22.98	71	79207	241193	50284653
Urinary tract infection	182.00	22.98	62	79216	223958	50301888
Vomiting	174.12	22.98	284	78994	460474	50065372
Fatigue	171.99	22.98	1775	77503	705826	49820020
Live birth	167.61	22.98	165	79113	16243	50509603
Neutropenia	163.08	22.98	20	79258	147945	50377901
Product dose omission issue	150.81	22.98	50	79228	183788	50342058
Back pain	148.29	22.98	80	79198	219950	50305896
Intentional product use issue	144.03	22.98	350	78928	76568	50449278
Thrombocytopenia	141.32	22.98	17	79261	127656	50398190
Haemoglobin decreased	140.66	22.98	17	79261	127199	50398647
Sepsis	139.28	22.98	21	79257	132904	50392942
Dizziness	138.80	22.98	205	79073	346164	50179682
Malaise	132.09	22.98	201	79077	335331	50190515
Weight decreased	131.66	22.98	93	79185	221152	50304694
Somnolence	127.36	22.98	42	79236	154943	50370903
Constipation	124.40	22.98	68	79210	185640	50340206
Dehydration	120.64	22.98	44	79234	152405	50373441
Toxicity to various agents	120.39	22.98	94	79184	212405	50313441
Infection	120.24	22.98	563	78715	172391	50353455
Sinusitis	119.15	22.98	556	78722	170002	50355844
Febrile neutropenia	115.86	22.98	10	79268	97657	50428189
Pancytopenia	113.77	22.98	4	79274	84026	50441820
Renal failure	113.66	22.98	16	79262	106617	50419229
Erythema	111.30	22.98	45	79233	146369	50379477
Hyponatraemia	110.95	22.98	11	79267	96128	50429718
Atrial fibrillation	109.08	22.98	15	79263	101730	50424116
Abdominal pain	107.62	22.98	127	79151	236101	50289745
Disease progression	105.49	22.98	13	79265	95853	50429993
Contusion	105.03	22.98	400	78878	111783	50414063
Injury	103.98	22.98	234	79044	48691	50477155
Drug tolerance decreased	100.85	22.98	96	79182	9064	50516782
Injection site pain	100.58	22.98	25	79253	110999	50414847
White blood cell count decreased	98.78	22.98	30	79248	116692	50409154
Adverse event	96.01	22.98	212	79066	43551	50482295
Cardiac failure	95.28	22.98	6	79272	76034	50449812
Renal impairment	94.71	22.98	6	79272	75655	50450191
Gastrointestinal haemorrhage	91.23	22.98	6	79272	73315	50452531
Myalgia	90.02	22.98	41	79237	124278	50401568
Malignant neoplasm progression	89.65	22.98	4	79274	68120	50457726
Platelet count decreased	88.71	22.98	24	79254	100702	50425144
Oxygen saturation decreased	88.25	22.98	7	79271	73241	50452605
Pain in extremity	83.76	22.98	190	79088	272675	50253171
Hypokalaemia	83.30	22.98	18	79260	87974	50437872
Blood pressure increased	83.11	22.98	53	79225	133079	50392767
Leukopenia	82.63	22.98	6	79272	67522	50458324
Blood creatinine increased	82.16	22.98	11	79267	76149	50449697
Oropharyngeal pain	82.14	22.98	12	79266	77789	50448057
Tremor	81.49	22.98	39	79239	114864	50410982
Respiratory failure	79.78	22.98	22	79256	91159	50434687
Myocardial infarction	78.80	22.98	21	79257	89006	50436840
Bradycardia	78.05	22.98	6	79272	64420	50461426
Herpes zoster	76.90	22.98	10	79268	70776	50455070
Syncope	76.09	22.98	33	79245	102969	50422877
Inappropriate schedule of product administration	76.02	22.98	11	79267	71820	50454026
Arthralgia	75.56	22.98	1032	78246	437670	50088176
Seizure	74.85	22.98	46	79232	117828	50408018
Neuropathy peripheral	73.08	22.98	30	79248	96727	50429119
Condition aggravated	72.86	22.98	748	78530	296310	50229536
Cerebrovascular accident	72.08	22.98	29	79249	94651	50431195
Completed suicide	71.33	22.98	61	79217	131828	50394018
Hypoglycaemia	70.99	22.98	3	79275	53578	50472268
Pleural effusion	70.62	22.98	20	79258	81434	50444412
Balance disorder	69.82	22.98	13	79265	70577	50455269
Cardiac failure congestive	69.05	22.98	23	79255	84359	50441487
Confusional state	68.38	22.98	512	78766	185416	50340430
Liver injury	68.33	22.98	132	79146	24674	50501172
Nasopharyngitis	66.89	22.98	524	78754	192403	50333443
Multiple organ dysfunction syndrome	66.09	22.98	3	79275	50334	50475512
Alanine aminotransferase increased	65.75	22.98	28	79250	88331	50437515
Influenza	65.64	22.98	29	79249	89509	50436337
Psoriasis	65.54	22.98	14	79264	68986	50456860
Chest discomfort	64.93	22.98	32	79246	92690	50433156
Septic shock	64.77	22.98	7	79271	57168	50468678
Blood glucose increased	64.70	22.98	16	79262	71308	50454538
Loss of consciousness	64.49	22.98	42	79236	104311	50421535
Injection site erythema	63.86	22.98	19	79259	74917	50450929
Tachycardia	63.24	22.98	39	79239	99724	50426122
Hyperkalaemia	62.70	22.98	3	79275	48086	50477760
Adverse drug reaction	61.96	22.98	209	79069	55013	50470833
Oedema peripheral	61.66	22.98	95	79183	157866	50367980
Aspartate aminotransferase increased	60.84	22.98	23	79255	77975	50447871
Chills	58.29	22.98	40	79238	96647	50429199
Overdose	57.84	22.98	43	79235	99684	50426162
Dyspnoea exertional	56.22	22.98	7	79271	51226	50474620
Influenza like illness	53.87	22.98	12	79266	57447	50468399
Blood pressure decreased	53.80	22.98	11	79267	55898	50469948
Cellulitis	53.37	22.98	22	79256	70776	50455070
Wrong technique in product usage process	53.26	22.98	11	79267	55499	50470347
Hyperhidrosis	52.58	22.98	38	79240	89388	50436458
Electrocardiogram QT prolonged	52.51	22.98	9	79269	51877	50473969
Dislocation of vertebra	51.48	22.98	41	79237	3046	50522800
Epistaxis	51.33	22.98	18	79260	63936	50461910
Abdominal distension	51.28	22.98	25	79253	72878	50452968
Anxiety	51.00	22.98	128	79150	177478	50348368
Fluid retention	50.79	22.98	9	79269	50640	50475206
Mucosal inflammation	50.78	22.98	3	79275	40139	50485707
Depressed level of consciousness	50.46	22.98	10	79268	51943	50473903
Adjustment disorder with depressed mood	50.44	22.98	39	79239	2775	50523071
Insomnia	50.23	22.98	126	79152	174739	50351107
Weight increased	50.19	22.98	510	78768	201381	50324465
Bronchitis	49.54	22.98	54	79224	104105	50421741
Breast cancer	49.23	22.98	5	79273	42885	50482961
Exposure during pregnancy	48.92	22.98	341	78937	120674	50405172
Peripheral swelling	48.72	22.98	515	78763	205421	50320425
Flushing	48.65	22.98	22	79256	66993	50458853
Intentional overdose	47.80	22.98	19	79259	62485	50463361
Productive cough	47.44	22.98	12	79266	52682	50473164
Cardiac arrest	47.31	22.98	37	79241	83614	50442232
Retinitis	47.18	22.98	32	79246	1855	50523991
Vision blurred	46.79	22.98	33	79245	78614	50447232
Feeling abnormal	46.58	22.98	78	79200	125414	50400432
Haemorrhage	46.54	22.98	13	79265	53428	50472418
Therapeutic product effect incomplete	46.29	22.98	45	79233	91470	50434376
Depression	46.12	22.98	121	79157	165302	50360544
Pregnancy	45.43	22.98	125	79153	29452	50496394
Decreased appetite	45.31	22.98	162	79116	200761	50325085
Hospitalisation	45.26	22.98	25	79253	67912	50457934
Injection site swelling	45.13	22.98	6	79272	41767	50484079
Vertigo	44.41	22.98	13	79265	51819	50474027
Pancreatitis	44.00	22.98	7	79271	42607	50483239
Heart rate increased	43.90	22.98	34	79244	77216	50448630
Pulmonary embolism	43.80	22.98	57	79221	101647	50424199
Blood pressure systolic increased	43.80	22.98	3	79275	35446	50490400
Rhabdomyolysis	43.64	22.98	5	79273	39022	50486824
Metabolic acidosis	43.35	22.98	5	79273	38820	50487026
Cystitis	42.40	22.98	9	79269	44555	50481291
Neutrophil count decreased	42.37	22.98	10	79268	46016	50479830
Chest pain	42.33	22.98	139	79139	176743	50349103
Hypoxia	41.70	22.98	14	79264	51109	50474737
Lethargy	41.27	22.98	13	79265	49419	50476427
Rash pruritic	41.00	22.98	12	79266	47834	50478012
Headache	40.83	22.98	554	78724	505981	50019865
Abortion spontaneous	40.65	22.98	8	79270	41764	50484082
Cardiac disorder	40.24	22.98	9	79269	42970	50482876
Heart rate decreased	40.01	22.98	5	79273	36492	50489354
Palpitations	39.65	22.98	54	79224	94452	50431394
Chronic obstructive pulmonary disease	39.64	22.98	17	79261	53418	50472428
Thrombosis	39.49	22.98	19	79259	55814	50470032
White blood cell count increased	39.24	22.98	9	79269	42231	50483615
Ascites	39.10	22.98	5	79273	35856	50489990
Speech disorder	38.65	22.98	5	79273	35543	50490303
Cardio-respiratory arrest	38.64	22.98	18	79260	53874	50471972
Disorientation	38.56	22.98	5	79273	35479	50490367
Drug abuse	38.47	22.98	23	79255	59823	50466023
Bone pain	38.41	22.98	13	79265	47216	50478630
Multiple sclerosis relapse	38.26	22.98	10	79268	42954	50482892
Paraesthesia	38.25	22.98	82	79196	120161	50405685
Incorrect dose administered	38.22	22.98	14	79264	48400	50477446
Liver function test abnormal	38.21	22.98	11	79267	44328	50481518
Lactic acidosis	37.99	22.98	4	79274	33351	50492495
Muscle spasms	37.99	22.98	88	79190	125465	50400381
Suicide attempt	37.52	22.98	17	79261	51715	50474131
Dysphagia	37.06	22.98	40	79238	77478	50448368
Hepatic function abnormal	37.01	22.98	4	79274	32677	50493169
Prescribed overdose	36.96	22.98	75	79203	14525	50511321
Femur fracture	36.82	22.98	7	79271	37457	50488389
Injection site pruritus	36.77	22.98	9	79269	40402	50485444
Rectal haemorrhage	36.25	22.98	8	79270	38550	50487296
Dyspnoea	36.25	22.98	622	78656	546986	49978860
Pain in jaw	36.07	22.98	8	79270	38420	50487426
Suicidal ideation	36.00	22.98	21	79257	55364	50470482
Seronegative arthritis	35.72	22.98	28	79250	2033	50523813
Pulmonary hypertension	35.62	22.98	5	79273	33412	50492434
Hyperglycaemia	35.36	22.98	7	79271	36398	50489448
Plasma cell myeloma	35.05	22.98	4	79274	31318	50494528
Coma	34.98	22.98	23	79255	56856	50468990
Skin discolouration	34.69	22.98	5	79273	32752	50493094
Dysarthria	34.68	22.98	8	79270	37395	50488451
Osteonecrosis of jaw	34.36	22.98	5	79273	32521	50493325
Pulmonary oedema	34.08	22.98	17	79261	48921	50476925
Red blood cell count decreased	33.95	22.98	6	79272	33829	50492017
Respiratory distress	33.86	22.98	4	79274	30485	50495361
Upper respiratory tract infection	33.79	22.98	32	79246	65866	50459980
Agitation	33.64	22.98	21	79257	53363	50472483
Prescribed underdose	33.55	22.98	76	79202	15873	50509973
X-ray abnormal	33.47	22.98	30	79248	2622	50523224
Angioedema	33.11	22.98	9	79269	37667	50488179
Burning sensation	32.86	22.98	15	79263	45431	50480415
Hepatitis	32.85	22.98	5	79273	31448	50494398
Anti-cyclic citrullinated peptide antibody	32.84	22.98	24	79254	1568	50524278
Mobility decreased	32.71	22.98	226	79052	79722	50446124
Blood pressure fluctuation	32.55	22.98	8	79270	35815	50490031
Haematemesis	32.43	22.98	3	79275	27722	50498124
Hepatic failure	31.80	22.98	6	79272	32277	50493569
Gastrooesophageal reflux disease	31.72	22.98	44	79234	76384	50449462
Encephalopathy	31.68	22.98	7	79271	33704	50492142
Sedation	31.66	22.98	5	79273	30605	50495241
International normalised ratio increased	31.58	22.98	14	79264	43138	50482708
Acute respiratory failure	31.41	22.98	4	79274	28778	50497068
Rash erythematous	31.25	22.98	8	79270	34844	50491002
Surgery	31.09	22.98	5	79273	30200	50495646
C-reactive protein increased	31.01	22.98	35	79243	66439	50459407
Asthma	30.91	22.98	58	79220	89279	50436567
Haematochezia	30.70	22.98	12	79266	39870	50485976
Cataract	30.65	22.98	18	79260	47282	50478564
Blood potassium decreased	30.34	22.98	10	79268	36935	50488911
Mouth ulceration	30.33	22.98	4	79274	28020	50497826
Injection site bruising	30.11	22.98	10	79268	36758	50489088
Muscular weakness	30.04	22.98	65	79213	94948	50430898
Skin ulcer	30.00	22.98	9	79269	35309	50490537
Hepatocellular injury	29.84	22.98	3	79275	25944	50499902
Acute myocardial infarction	29.79	22.98	5	79273	29268	50496578
Lymphadenopathy	29.44	22.98	8	79270	33491	50492355
Hepatotoxicity	29.20	22.98	4	79274	27222	50498624
Unevaluable event	29.19	22.98	18	79260	46048	50479798
Localised infection	29.17	22.98	3	79275	25482	50500364
Maternal exposure timing unspecified	29.05	22.98	32	79246	3588	50522258
Diverticulitis	29.02	22.98	8	79270	33174	50492672
Throat irritation	28.99	22.98	6	79272	30233	50495613
Musculoskeletal pain	28.53	22.98	43	79235	72134	50453712
Body temperature increased	28.48	22.98	7	79271	31334	50494512
Dyskinesia	27.82	22.98	5	79273	27856	50497990
Transaminases increased	27.77	22.98	5	79273	27819	50498027
Blood alkaline phosphatase increased	27.73	22.98	12	79266	37514	50488332
No adverse event	27.73	22.98	9	79269	33569	50492277
Deep vein thrombosis postoperative	27.52	22.98	22	79256	1643	50524203
Therapy cessation	27.47	22.98	4	79274	26007	50499839
Colitis	27.41	22.98	13	79265	38516	50487330
Haematoma	27.36	22.98	7	79271	30503	50495343
Device expulsion	27.05	22.98	6	79272	28816	50497030
Interstitial lung disease	27.05	22.98	26	79252	53150	50472696
Cognitive disorder	26.92	22.98	18	79260	44105	50481741
Pericardial effusion	26.88	22.98	4	79274	25585	50500261
Fungal infection	26.63	22.98	7	79271	29958	50495888
Depressed mood	26.58	22.98	10	79268	34013	50491833
Stress	26.56	22.98	27	79251	53766	50472080
Rhinorrhoea	26.50	22.98	25	79253	51558	50474288
Drug eruption	26.45	22.98	3	79275	23603	50502243
Dysphonia	26.35	22.98	14	79264	38878	50486968
Skin lesion	26.25	22.98	5	79273	26722	50499124
Mental status changes	26.18	22.98	12	79266	36260	50489586
Pneumonia aspiration	26.15	22.98	8	79270	30996	50494850
Basal cell carcinoma	26.09	22.98	3	79275	23353	50502493
Skin exfoliation	26.06	22.98	10	79268	33602	50492244
Arthritis	26.05	22.98	61	79217	86660	50439186
Intentional product misuse	26.01	22.98	21	79257	46713	50479133
Injection site reaction	25.99	22.98	24	79254	50008	50475838
Gastroenteritis	25.99	22.98	3	79275	23278	50502568
Chronic kidney disease	25.96	22.98	15	79263	39756	50486090
Transient ischaemic attack	25.96	22.98	9	79269	32201	50493645
Jaundice	25.84	22.98	5	79273	26424	50499422
Accidental exposure to product	25.66	22.98	3	79275	23054	50502792
Urinary retention	25.51	22.98	5	79273	26185	50499661
Hypothyroidism	25.08	22.98	11	79267	34114	50491732
Dysgeusia	24.95	22.98	15	79263	38901	50486945
Breast cancer stage III	24.78	22.98	28	79250	3228	50522618
Haemoptysis	24.67	22.98	5	79273	25568	50500278
Cerebral haemorrhage	24.66	22.98	6	79272	27046	50498800
Respiratory disorder	24.64	22.98	9	79269	31178	50494668
Drug reaction with eosinophilia and systemic symptoms	24.59	22.98	7	79271	28417	50497429
Haematocrit decreased	24.58	22.98	12	79266	34964	50490882
Neoplasm malignant	24.24	22.98	4	79274	23711	50502135
Pneumonitis	24.21	22.98	8	79270	29502	50496344
Orthostatic hypotension	24.17	22.98	8	79270	29473	50496373
Facet joint syndrome	24.14	22.98	24	79254	2389	50523457
Deep vein thrombosis	24.13	22.98	49	79229	73255	50452591
Rash maculo-papular	24.11	22.98	6	79272	26635	50499211
Blood urea increased	24.06	22.98	4	79274	23581	50502265
Respiratory tract infection	24.04	22.98	10	79268	32007	50493839
Feeling hot	23.91	22.98	16	79262	39186	50486660
Staphylococcal infection	23.87	22.98	13	79265	35603	50490243
Blood creatine phosphokinase increased	23.74	22.98	6	79272	26361	50499485
Hypophagia	23.67	22.98	7	79271	27721	50498125
Gastritis	23.67	22.98	11	79267	32972	50492874
Lymphocyte count decreased	23.66	22.98	6	79272	26301	50499545
Grip strength decreased	23.56	22.98	56	79222	12065	50513781
Lip dry	23.40	22.98	33	79245	4754	50521092
Renal disorder	23.38	22.98	7	79271	27498	50498348
Hot flush	23.17	22.98	21	79257	44148	50481698
Hip fracture	23.16	22.98	6	79272	25925	50499921
Therapeutic response decreased	22.99	22.98	24	79254	47207	50478639

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sudden infant death syndrome	65.67	15.51	13	5007	168	29569339
Cardiac septal defect	55.84	15.51	12	5008	237	29569270
Kidney duplex	49.94	15.51	12	5008	396	29569111
Toxicity to various agents	43.74	15.51	93	4927	173568	29395939
Substance abuser	29.99	15.51	6	5014	82	29569425
Hypoxic-ischaemic encephalopathy	25.23	15.51	13	5007	4271	29565236
Tachycardia	18.40	15.51	39	4981	72371	29497136
Nasal congestion	18.05	15.51	19	5001	18860	29550647

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	2194.32	19.40	1073	56486	59628	64381545
Systemic lupus erythematosus	2050.93	19.40	1111	56448	76501	64364672
Pericarditis	2002.17	19.40	1018	56541	61498	64379675
Glossodynia	1874.48	19.40	985	56574	63711	64377462
Hand deformity	1802.27	19.40	950	56609	61821	64379352
Anti-cyclic citrullinated peptide antibody positive	1783.99	19.40	874	56685	48688	64392485
Wound	1647.91	19.40	958	56601	75519	64365654
Discomfort	1505.23	19.40	922	56637	79956	64361217
Synovitis	1431.63	19.40	963	56596	98127	64343046
Arthropathy	1298.58	19.40	981	56578	119986	64321187
Alopecia	1281.51	19.40	1109	56450	164581	64276592
Duodenal ulcer perforation	1276.30	19.40	621	56938	34004	64407169
Abdominal discomfort	1240.67	19.40	1135	56424	181187	64259986
Helicobacter infection	1227.60	19.40	625	56934	37737	64403436
Swelling	1116.09	19.40	1011	56548	159207	64281966
Hepatic enzyme increased	1102.87	19.40	918	56641	129025	64312148
Maternal exposure during pregnancy	1033.57	19.40	780	56779	95104	64346069
Hypersensitivity	991.68	19.40	1039	56520	195413	64245760
Contraindicated product administered	971.52	19.40	789	56770	107040	64334133
Infusion related reaction	948.52	19.40	935	56624	163532	64277641
Rheumatoid factor positive	868.02	19.40	481	57078	34457	64406716
Drug intolerance	835.59	19.40	930	56629	187062	64254111
Joint swelling	771.68	19.40	954	56605	214428	64226745
Irritable bowel syndrome	768.95	19.40	455	57104	36914	64404259
Muscle injury	759.88	19.40	401	57158	26036	64415137
Folliculitis	724.96	19.40	406	57153	29671	64411502
Blister	723.54	19.40	590	56969	80377	64360796
Therapeutic product effect decreased	707.76	19.40	679	56880	114672	64326501
Sleep disorder due to general medical condition, insomnia type	691.93	19.40	376	57183	25894	64415279
Rheumatoid arthritis	478.81	19.40	658	56901	163636	64277537
Impaired healing	474.43	19.40	409	57150	60064	64381109
Treatment failure	432.78	19.40	527	57032	116289	64324884
Product use issue	418.61	19.40	592	56967	151123	64290050
Pain	402.04	19.40	1242	56317	552269	63888904
Rheumatic fever	348.95	19.40	169	57390	9125	64432048
Stomatitis	344.92	19.40	456	57103	109149	64332024
Rash	338.99	19.40	1036	56523	457513	63983660
Lower respiratory tract infection	321.65	19.40	409	57150	94205	64346968
Gastrointestinal disorder	319.61	19.40	397	57162	89312	64351861
Swollen joint count increased	310.51	19.40	147	57412	7542	64433631
Ill-defined disorder	305.60	19.40	278	57281	43774	64397399
Acute kidney injury	294.33	19.40	30	57529	449210	63991963
Sinusitis	268.34	19.40	473	57086	145455	64295718
Hip arthroplasty	248.01	19.40	182	57377	21169	64420004
Anaemia	241.04	19.40	28	57531	378652	64062521
Infection	203.85	19.40	485	57074	184395	64256778
Death	196.20	19.40	93	57466	482612	63958561
Fall	196.17	19.40	64	57495	416762	64024411
Knee arthroplasty	194.30	19.40	174	57385	26825	64414348
Pneumonia	190.26	19.40	134	57425	559442	63881731
Type 2 diabetes mellitus	189.02	19.40	190	57369	33830	64407343
Hypotension	183.69	19.40	56	57503	380918	64060255
Diarrhoea	179.30	19.40	230	57329	722474	63718699
Nausea	171.37	19.40	274	57285	785526	63655647
Blood cholesterol increased	170.88	19.40	217	57342	49849	64391324
Drug interaction	166.12	19.40	58	57501	362025	64079148
Musculoskeletal stiffness	161.10	19.40	346	57213	122860	64318313
Contusion	157.05	19.40	327	57232	113638	64327535
Nasopharyngitis	141.32	19.40	440	57119	195633	64245540
Neutropenia	135.49	19.40	25	57534	239599	64201574
Arthralgia	132.52	19.40	758	56801	441502	63999671
Thrombocytopenia	131.70	19.40	21	57538	223780	64217393
Adverse event	129.77	19.40	168	57391	39321	64401852
Fatigue	127.45	19.40	1118	56441	747612	63693561
Drug ineffective	120.71	19.40	1210	56349	839037	63602136
Weight increased	120.36	19.40	441	57118	212907	64228266
Sepsis	118.09	19.40	30	57529	230311	64210862
Peripheral swelling	116.02	19.40	430	57129	208723	64232450
Injury	113.91	19.40	190	57369	55802	64385371
Live birth	111.27	19.40	87	57472	11117	64430056
Pregnancy	111.26	19.40	114	57445	20751	64420422
Febrile neutropenia	109.51	19.40	18	57541	187639	64253534
Vomiting	107.27	19.40	206	57353	550911	63890262
Pancytopenia	106.81	19.40	5	57554	143304	64297869
Asthenia	100.97	19.40	141	57418	427903	64013270
Cough	97.72	19.40	76	57483	302072	64139101
Renal failure	96.37	19.40	22	57537	181666	64259507
Intentional product use issue	96.23	19.40	242	57317	95122	64346051
Haemoglobin decreased	95.10	19.40	28	57531	195035	64246138
Cardiac failure	91.46	19.40	7	57552	132366	64308807
Platelet count decreased	89.56	19.40	20	57539	167691	64273482
Exposure during pregnancy	87.85	19.40	206	57353	77469	64363704
Hyponatraemia	87.05	19.40	14	57545	148325	64292848
Urinary tract infection	84.52	19.40	51	57508	231545	64209628
Renal impairment	83.26	19.40	11	57548	135006	64306167
Adverse drug reaction	79.07	19.40	144	57415	45320	64395853
Confusional state	77.59	19.40	447	57112	260697	64180476
Disease progression	77.47	19.40	16	57543	141664	64299509
Bradycardia	76.95	19.40	8	57551	118211	64322962
Somnolence	76.92	19.40	43	57516	203602	64237571
Dehydration	74.63	19.40	51	57508	216712	64224461
Malignant neoplasm progression	72.54	19.40	8	57551	112863	64328310
Atrial fibrillation	72.38	19.40	31	57528	171058	64270115
Pruritus	71.88	19.40	501	57058	311899	64129274
Septic shock	71.65	19.40	6	57553	105431	64335742
General physical health deterioration	71.56	19.40	366	57193	204059	64237114
Multiple organ dysfunction syndrome	71.09	19.40	5	57554	101408	64339765
White blood cell count decreased	71.04	19.40	26	57533	157811	64283362
Hyperkalaemia	70.85	19.40	5	57554	101124	64340049
Gastrointestinal haemorrhage	70.19	19.40	16	57543	132296	64308877
Sudden infant death syndrome	68.02	19.40	18	57541	153	64441020
Respiratory failure	66.93	19.40	30	57529	161153	64280020
Constipation	66.44	19.40	64	57495	229273	64211900
Oxygen saturation decreased	65.44	19.40	9	57550	107167	64334006
Blood creatinine increased	65.23	19.40	20	57539	135762	64305411
Weight decreased	64.46	19.40	97	57462	285642	64155531
Erythema	64.40	19.40	44	57515	187026	64254147
Hypoglycaemia	64.28	19.40	4	57555	89888	64351285
Adjustment disorder with depressed mood	64.16	19.40	35	57524	2422	64438751
Leukopenia	63.01	19.40	8	57551	101234	64339939
Myocardial infarction	62.63	19.40	35	57524	165786	64275387
Dislocation of vertebra	61.47	19.40	37	57522	3087	64438086
Cardiac failure congestive	61.36	19.40	20	57539	130560	64310613
Product dose omission issue	60.40	19.40	51	57508	194696	64246477
Rhabdomyolysis	60.23	19.40	6	57553	91720	64349453
Retinitis	58.07	19.40	31	57528	2054	64439119
Hypokalaemia	56.70	19.40	19	57540	121884	64319289
Back pain	55.38	19.40	86	57473	250085	64191088
Abdominal pain	53.71	19.40	125	57434	312250	64128923
Maternal exposure timing unspecified	53.10	19.40	32	57527	2675	64438498
Alanine aminotransferase increased	50.15	19.40	31	57528	139000	64302173
Blood pressure increased	50.13	19.40	48	57511	172504	64268669
Inappropriate schedule of product administration	49.26	19.40	11	57548	92275	64348898
Pain in extremity	49.18	19.40	125	57434	302960	64138213
Pleural effusion	48.82	19.40	26	57533	126533	64314640
Syncope	47.99	19.40	42	57517	157593	64283580
Fibromyalgia	46.23	19.40	100	57459	35631	64405542
Injection site pain	45.82	19.40	21	57538	111387	64329786
Metabolic acidosis	45.66	19.40	5	57554	70953	64370220
Aspartate aminotransferase increased	45.63	19.40	25	57534	119763	64321410
Hepatic function abnormal	45.57	19.40	3	57556	64310	64376863
Oropharyngeal pain	44.68	19.40	12	57547	88855	64352318
Herpes zoster	43.15	19.40	9	57550	79178	64361995
Malaise	42.77	19.40	195	57364	396052	64045121
Seronegative arthritis	42.69	19.40	28	57531	2715	64438458
Neuropathy peripheral	42.67	19.40	26	57533	117499	64323674
Seizure	42.30	19.40	52	57507	166840	64274333
Off label use	42.10	19.40	362	57197	632444	63808729
COVID-19	40.89	19.40	5	57554	65135	64376038
Toxicity to various agents	40.36	19.40	177	57382	363336	64077837
Lactic acidosis	40.36	19.40	4	57555	61406	64379767
Tremor	39.92	19.40	44	57515	148186	64292987
Blood glucose increased	39.54	19.40	19	57540	98054	64343119
Depressed level of consciousness	39.09	19.40	12	57547	81424	64359749
Chest discomfort	39.03	19.40	28	57531	116078	64325095
Prescribed overdose	38.69	19.40	67	57492	20264	64420909
Myalgia	38.56	19.40	51	57508	158566	64282607
Influenza	38.08	19.40	24	57535	106507	64334666
Loss of consciousness	37.84	19.40	46	57513	148319	64292854
Dizziness	37.83	19.40	227	57332	429936	64011237
Neutrophil count decreased	37.74	19.40	11	57548	77185	64363988
Blood pressure decreased	37.44	19.40	15	57544	86184	64354989
Hypoxia	37.22	19.40	16	57543	88133	64353040
Dyspnoea exertional	36.98	19.40	10	57549	73720	64367453
Anti-cyclic citrullinated peptide antibody	36.96	19.40	20	57539	1362	64439811
Mucosal inflammation	36.49	19.40	6	57553	62578	64378595
Cellulitis	36.47	19.40	19	57540	93638	64347535
Condition aggravated	35.98	19.40	498	57061	371928	64069245
Electrocardiogram QT prolonged	35.88	19.40	13	57546	79435	64361738
Epistaxis	35.22	19.40	22	57537	98109	64343064
Haematuria	34.81	19.40	6	57553	60465	64380708
Cerebrovascular accident	34.72	19.40	43	57516	137540	64303633
Breast cancer stage III	34.25	19.40	25	57534	2880	64438293
Wrong technique in product usage process	34.16	19.40	8	57551	64966	64376207
International normalised ratio increased	34.02	19.40	14	57545	79153	64362020
Ascites	33.88	19.40	7	57552	61994	64379179
Abdominal distension	33.79	19.40	22	57537	95972	64345201
Rectal haemorrhage	33.74	19.40	7	57552	61810	64379363
Psoriasis	33.64	19.40	11	57548	71692	64369481
Productive cough	33.02	19.40	12	57547	73191	64367982
Haemorrhage	32.56	19.40	15	57544	79336	64361837
Blood bilirubin increased	32.50	19.40	6	57553	57547	64383626
Pneumonia aspiration	31.76	19.40	7	57552	59264	64381909
Oedema peripheral	31.62	19.40	90	57469	210227	64230946
Deep vein thrombosis postoperative	31.62	19.40	18	57541	1353	64439820
Mobility decreased	31.61	19.40	156	57403	85684	64355489
Chills	31.49	19.40	46	57513	137218	64303955
Liver injury	31.25	19.40	77	57482	29855	64411318
Cardiac arrest	31.25	19.40	56	57503	154008	64287165
Disorientation	31.14	19.40	6	57553	55822	64385351
Interstitial lung disease	31.01	19.40	25	57534	97707	64343466
Pulmonary oedema	30.57	19.40	16	57543	78658	64362515
Haemoptysis	30.21	19.40	4	57555	49044	64392129
Drug tolerance decreased	29.87	19.40	34	57525	6964	64434209
Grip strength decreased	29.67	19.40	44	57515	11680	64429493
Hepatocellular injury	29.58	19.40	3	57556	45232	64395941
White blood cell count increased	29.47	19.40	11	57548	66003	64375170
Encephalopathy	29.46	19.40	8	57551	58811	64382362
Walking aid user	29.36	19.40	32	57527	6249	64434924
Melaena	29.35	19.40	6	57553	53542	64387631
Drug abuse	28.79	19.40	46	57513	132328	64308845
Respiratory distress	28.40	19.40	6	57553	52325	64388848
Dysarthria	28.07	19.40	9	57550	59397	64381776
Drug reaction with eosinophilia and systemic symptoms	27.87	19.40	7	57552	54210	64386963
Pulmonary hypertension	27.85	19.40	3	57556	43136	64398037
Vertigo	27.78	19.40	9	57550	59002	64382171
Pancreatitis acute	27.62	19.40	3	57556	42852	64398321
Gamma-glutamyltransferase increased	27.51	19.40	5	57554	48505	64392668
Hepatitis	27.41	19.40	4	57555	45578	64395595
Balance disorder	27.22	19.40	21	57538	83905	64357268
Chronic obstructive pulmonary disease	26.80	19.40	15	57544	71033	64370140
Heart rate decreased	26.64	19.40	8	57551	55059	64386114
Acute respiratory failure	26.54	19.40	6	57553	49928	64391245
Fluid retention	26.50	19.40	10	57549	59596	64381577
Lip dry	26.45	19.40	27	57532	4891	64436282
Facet joint syndrome	26.14	19.40	18	57541	1891	64439282
Coma	25.87	19.40	24	57535	87591	64353582
Hyperglycaemia	25.84	19.40	11	57548	60957	64380216
Red blood cell count decreased	25.35	19.40	6	57553	48380	64392793
Osteonecrosis of jaw	25.13	19.40	3	57556	39822	64401351
Pancreatitis	24.87	19.40	11	57548	59596	64381577
Influenza like illness	24.80	19.40	12	57547	61690	64379483
Tachycardia	24.76	19.40	61	57498	149518	64291655
Haematemesis	24.29	19.40	6	57553	46993	64394180
Blood pressure fluctuation	24.26	19.40	8	57551	51863	64389310
Blood pressure systolic increased	24.26	19.40	7	57552	49446	64391727
Blood creatine phosphokinase increased	24.13	19.40	11	57548	58547	64382626
Injection site erythema	23.88	19.40	17	57542	70783	64370390
Agranulocytosis	23.83	19.40	3	57556	38226	64402947
Thrombosis	23.78	19.40	17	57542	70625	64370548
Plasma cell myeloma	23.58	19.40	6	57553	46069	64395104
Lymphocyte count decreased	23.51	19.40	4	57555	40695	64400478
Exostosis	23.49	19.40	39	57520	11399	64429774
Hepatic failure	23.47	19.40	10	57549	55384	64385789
Spinal fusion surgery	23.28	19.40	22	57537	3629	64437544
Hypomagnesaemia	23.14	19.40	3	57556	37373	64403800
Toxic epidermal necrolysis	22.97	19.40	3	57556	37163	64404010
Heart rate increased	22.70	19.40	33	57526	98642	64342531
Incorrect dose administered	22.68	19.40	13	57546	60752	64380421
Completed suicide	22.67	19.40	113	57446	224301	64216872
Pulmonary embolism	22.46	19.40	62	57497	146294	64294879
Skin lesion	22.41	19.40	3	57556	36479	64404694
Blood urea increased	22.12	19.40	6	57553	44147	64397026
Cerebral haemorrhage	22.00	19.40	9	57550	51081	64390092
Liver function test abnormal	21.75	19.40	13	57546	59388	64381785
Flushing	21.55	19.40	23	57536	78625	64362548
Hyperhidrosis	21.42	19.40	50	57509	124870	64316303
Lethargy	21.29	19.40	20	57539	72574	64368599
Lupus-like syndrome	20.84	19.40	32	57527	8759	64432414
Transaminases increased	20.64	19.40	7	57552	44587	64396586
Rash pruritic	20.41	19.40	13	57546	57391	64383782
Jaundice	20.17	19.40	9	57550	48503	64392670
Haematoma	20.16	19.40	8	57551	46242	64394931
Colitis	19.91	19.40	14	57545	58660	64382513
Haematochezia	19.81	19.40	18	57541	66355	64374818
C-reactive protein increased	19.69	19.40	34	57525	94875	64346298
Blood alkaline phosphatase increased	19.67	19.40	13	57546	56266	64384907
Acute myocardial infarction	19.53	19.40	20	57539	69698	64371475
Decreased appetite	19.49	19.40	159	57400	281130	64160043

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R01BA02	RESPIRATORY SYSTEM NASAL PREPARATIONS NASAL DECONGESTANTS FOR SYSTEMIC USE Sympathomimetics
ATC	R01BA52	RESPIRATORY SYSTEM NASAL PREPARATIONS NASAL DECONGESTANTS FOR SYSTEMIC USE Sympathomimetics
FDA MoA	N0000000209	Adrenergic alpha-Agonists
FDA EPC	N0000175552	alpha-Adrenergic Agonist
CHEBI has role	CHEBI:35470	central nervous system agents
CHEBI has role	CHEBI:35523	bronchodilator
CHEBI has role	CHEBI:35524	sympathomimetic
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:49167	anti-asthmatic drugs
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77715	nasal decongestants
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D014663	Nasal Decongestants
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D019141	Respiratory System Agents
MeSH PA	D014662	Vasoconstrictor Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Sinus headache	indication	4969004
Vasomotor rhinitis	indication	8229003	DOID:4730
Allergic rhinitis	indication	61582004
Nasal discharge	indication	64531003
Nasal congestion	indication	68235000
Rhinitis	indication	70076002	DOID:4483
Common cold	indication	82272006	DOID:10459
Headache disorder	indication	230461009
Influenza-like symptoms	indication	315642008
Seasonal allergic rhinitis	indication	367498001
Allergic conjunctivitis	indication	473460002	DOID:11204
Eustachian Tube Congestion	indication
Brain damage	contraindication	2470005
Ocular hypertension	contraindication	4210003	DOID:9282
Tachyarrhythmia	contraindication	6285003
Suicidal thoughts	contraindication	6471006
Dependent drug abuse	contraindication	6525002
Urinary tract obstruction	contraindication	7163005	DOID:5200
Alcoholism	contraindication	7200002
Alcohol withdrawal delirium	contraindication	8635005
Peptic ulcer	contraindication	13200003	DOID:750
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Asthenia	contraindication	13791008
Hyperkalemia	contraindication	14140009
Severe chronic ulcerative colitis	contraindication	14311001
Constipation	contraindication	14760008	DOID:2089
Disorder of autonomic nervous system	contraindication	15241006
Chronic disease of respiratory system	contraindication	17097001
Mood swings	contraindication	18963009
Pulmonary edema	contraindication	19242006	DOID:11396
Myocardial infarction	contraindication	22298006	DOID:5844
Glaucoma	contraindication	23986001	DOID:1686
Inflammatory bowel disease	contraindication	24526004	DOID:0050589
Ventricular tachycardia	contraindication	25569003
Alcohol intoxication	contraindication	25702006
Shock	contraindication	27942005
Toxic megacolon	contraindication	28536002	DOID:1770
Atony of colon	contraindication	29479008
Hypercapnia	contraindication	29596007
Dehydration	contraindication	34095006
Hyperthyroidism	contraindication	34486009	DOID:7998
Acute hepatitis	contraindication	37871000
Hypertensive disorder	contraindication	38341003	DOID:10763
Hypovolemic shock	contraindication	39419009
Disorder of gallbladder	contraindication	39621005	DOID:0060262
Gastrointestinal ulcer	contraindication	40845000
Hypothyroidism	contraindication	40930008	DOID:1459
Complete trisomy 21 syndrome	contraindication	41040004	DOID:14250
Third trimester pregnancy	contraindication	41587001
Body fluid retention	contraindication	43498006
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Achalasia of esophagus	contraindication	45564002	DOID:9164
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Acidosis	contraindication	51387008
Gastrointestinal perforation	contraindication	51875005
Coronary arteriosclerosis	contraindication	53741008	DOID:3393
Paralytic ileus	contraindication	55525008	DOID:8442
Peptic reflux disease	contraindication	57643001
Multiple organ failure	contraindication	57653000
Acute nephropathy	contraindication	58574008
Metabolic acidosis	contraindication	59455009
Hepatic failure	contraindication	59927004
Ulcerative colitis	contraindication	64766004	DOID:8577
Blood coagulation disorder	contraindication	64779008	DOID:1247
Arterial thrombosis	contraindication	65198009
Drug AND/OR toxin-induced diarrhea	contraindication	65979008
Substance abuse	contraindication	66214007
Benign intracranial hypertension	contraindication	68267002	DOID:11459
Poisoning by acetaminophen	contraindication	70273001
Arteriosclerotic vascular disease	contraindication	72092001
Diabetes mellitus	contraindication	73211009	DOID:9351
Gastrointestinal hemorrhage	contraindication	74474003
Urethral stricture	contraindication	76618002
Spastic paralysis	contraindication	78403003
Disturbance of salivary secretion	contraindication	78948009
Decreased respiratory function	contraindication	80954004
Injury of head	contraindication	82271004
Chronic idiopathic constipation	contraindication	82934008
Cor pulmonale	contraindication	83291003	DOID:8515
Hiatal hernia	contraindication	84089009	DOID:12642
Epilepsy	contraindication	84757009	DOID:1826
Pulmonary emphysema	contraindication	87433001
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Acute abdominal pain	contraindication	116290004
Procedure on urinary system	contraindication	118677009
Gastrointestinal obstruction	contraindication	126765001
Neoplasm of brain	contraindication	126952004	DOID:1319
Seizure disorder	contraindication	128613002
Autonomic dysreflexia	contraindication	129618003
Bleeding	contraindication	131148009
Liver function tests abnormal	contraindication	166603001
Cystic fibrosis	contraindication	190905008	DOID:1485
Drug-induced psychosis	contraindication	191483003	DOID:1742
Angina pectoris	contraindication	194828000
Partial atrioventricular block	contraindication	195039008
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Cerebrovascular accident	contraindication	230690007
Coronary artery bypass graft	contraindication	232717009
Myocardial dysfunction	contraindication	233928007
Gastroesophageal reflux disease	contraindication	235595009	DOID:8534
Disease of liver	contraindication	235856003	DOID:409
Hyporeninemic hypoaldosteronism	contraindication	236464008
Bladder outflow obstruction	contraindication	236645006
Morbid obesity	contraindication	238136002	DOID:11981
Sepsis syndrome	contraindication	238150007
Rhabdomyolysis	contraindication	240131006
Pyloric obstruction	contraindication	244815007
Esophageal dysmotility	contraindication	266434009	DOID:9192
Benign prostatic hyperplasia	contraindication	266569009
Edema	contraindication	267038008
Retention of urine	contraindication	267064002
Anemia	contraindication	271737000	DOID:2355
Continuous fever	contraindication	271751000
Drowsy	contraindication	271782001
Exacerbation of asthma	contraindication	281239006
Pregnancy, function	contraindication	289908002
Lesion of brain	contraindication	301766008
Thromboembolic disorder	contraindication	371039008
Coma	contraindication	371632003
Primary adrenocortical insufficiency	contraindication	373662000
Smoking cessation assistance	contraindication	384742004
Operation on gastrointestinal tract	contraindication	386621005
Hypoxia	contraindication	389086002
Angle-closure glaucoma	contraindication	392291006	DOID:13550
Cardiovascular event risk	contraindication	395112001
Pseudomembranous enterocolitis	contraindication	397683000
Gastric ulcer	contraindication	397825006	DOID:10808
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Disorder of coronary artery	contraindication	414024009
Traumatic injury	contraindication	417746004
Central nervous system depression	contraindication	418072004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant	contraindication	422681000
Fever greater than 100.4 Fahrenheit	contraindication	426000000
Dysfunction of sphincter of Oddi	contraindication	430887001
Hypertensive urgency	contraindication	443482000
Smokes tobacco daily	contraindication	449868002
Acute exacerbation of asthma	contraindication	708038006
Acute Thromboembolic Stroke	contraindication
Theophylline Toxicity	contraindication
Severe Hypoxemia	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.22	Basic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
5MG;120MG	ZYRTEC-D 12 HOUR	J AND J CONSUMER INC	N021150	Nov. 9, 2007	OTC	TABLET, EXTENDED RELEASE	ORAL	7226614	June 10, 2022	TREATMENT OF SEASONAL AND PERENNIAL ALLERGIC RHINITIS SYMPTOMS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	RELEASING AGENT				CHEMBL	CHEMBL
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN					WOMBAT-PK
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN					WOMBAT-PK
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN					WOMBAT-PK

External reference:

ID	Source
4018571	VUID
N0000178581	NUI
D00485	KEGG_DRUG
345-78-8	SECONDARY_CAS_RN
7460-12-0	SECONDARY_CAS_RN
4018043	VANDF
4018571	VANDF
4018802	VANDF
C0033798	UMLSCUI
CHEBI:51209	CHEBI
CHEMBL1590	ChEMBL_ID
DB00852	DRUGBANK_ID
CHEMBL1200724	ChEMBL_ID
CHEMBL3989855	ChEMBL_ID
D054199	MESH_DESCRIPTOR_UI
7028	PUBCHEM_CID
1061	INN_ID
7286	IUPHAR_LIGAND_ID
7CUC9DDI9F	UNII
407885	RXNORM
2354	MMSL
5382	MMSL
5383	MMSL
5384	MMSL
d00769	MMSL
001831	NDDF
001832	NDDF
001833	NDDF
005972	NDDF
10595003	SNOMEDCT_US
12177002	SNOMEDCT_US
372900003	SNOMEDCT_US
91435002	SNOMEDCT_US
CHEMBL1201483	ChEMBL_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Dimetapp	HUMAN OTC DRUG LABEL	2	0031-2231	ELIXIR	15 mg	ORAL	Export only	15 sections
Dimetapp Paediatric	HUMAN OTC DRUG LABEL	2	0031-2251	ELIXIR	15 mg	ORAL	Export only	1 sections
Robitussin CF	HUMAN OTC DRUG LABEL	3	0031-8678	LIQUID	30 mg	ORAL	Export only	15 sections
Good Sense Suphedrine12 Hour	HUMAN OTC DRUG LABEL	1	0113-0054	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
good sense all day allergy d	HUMAN OTC DRUG LABEL	2	0113-0147	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
Good Sense All Day Allergy D	HUMAN OTC DRUG LABEL	2	0113-0176	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
Zephrex D	HUMAN OTC DRUG LABEL	1	0113-0401	CAPSULE, GELATIN COATED	30 mg	ORAL	OTC monograph final	14 sections
Good Sense Nasal Decongestant	HUMAN OTC DRUG LABEL	1	0113-0432	TABLET, FILM COATED	30 mg	ORAL	OTC monograph final	15 sections
Mucus D	HUMAN OTC DRUG LABEL	2	0113-2002	TABLET	60 mg	ORAL	ANDA	14 sections
Allergy and Congestion Relief	HUMAN OTC DRUG LABEL	2	0113-2007	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
sinus congestion	HUMAN OTC DRUG LABEL	1	0113-2008	TABLET, FILM COATED	30 mg	ORAL	OTC monograph final	15 sections
sinus 12 hour	HUMAN OTC DRUG LABEL	1	0113-2017	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
All Day Allergy-D	HUMAN OTC DRUG LABEL	2	0113-2176	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
perrigo allergy d	HUMAN OTC DRUG LABEL	2	0113-7777	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	15 sections
Brompheniramine Maleate, Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide	HUMAN PRESCRIPTION DRUG LABEL	3	0121-0933	SOLUTION	30 mg	ORAL	ANDA	21 sections
Aleve-D Sinus and Headache	HUMAN OTC DRUG LABEL	2	0280-6045	TABLET	120 mg	ORAL	ANDA	17 sections
Aleve-D Sinus and Cold	HUMAN OTC DRUG LABEL	2	0280-6090	TABLET	120 mg	ORAL	ANDA	17 sections
walphed dmaximum strength non drowsy sinus	HUMAN OTC DRUG LABEL	1	0363-0061	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
Guaifenesin and Pseudoephedrine Hydrochloride	HUMAN OTC DRUG LABEL	2	0363-0077	TABLET, EXTENDED RELEASE	60 mg	ORAL	NDA	16 sections
Fexofenadine Hydrochloride and Pseudoephedrine Hydrochloride	Human OTC Drug Label	2	0363-0094	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	11 sections
Wal-phed	HUMAN OTC DRUG LABEL	2	0363-0111	TABLET	60 mg	ORAL	OTC monograph final	16 sections
Wal-phed	HUMAN OTC DRUG LABEL	2	0363-0111	TABLET	60 mg	ORAL	OTC monograph final	16 sections
Wal-phed	HUMAN OTC DRUG LABEL	1	0363-0112	TABLET, FILM COATED	30 mg	ORAL	OTC monograph final	15 sections
Guaifenesin and Pseudoephedrine HCl	Human OTC Drug Label	2	0363-0134	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
Guaifenesin and Pseudoephedrine HCl	Human OTC Drug Label	2	0363-0134	TABLET, EXTENDED RELEASE	120 mg	ORAL	ANDA	14 sections
Mucus Relief D	HUMAN OTC DRUG LABEL	2	0363-0144	TABLET, EXTENDED RELEASE	60 mg	ORAL	ANDA	14 sections
Wal-Act	HUMAN OTC DRUG LABEL	2	0363-0178	TABLET, FILM COATED	60 mg	ORAL	OTC monograph final	16 sections
Pseudoephedrine Hydrochloride	HUMAN OTC DRUG LABEL	1	0363-0204	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
Pseudoephedrine Hydrochloride	HUMAN OTC DRUG LABEL	1	0363-0204	TABLET, FILM COATED, EXTENDED RELEASE	120 mg	ORAL	ANDA	16 sections
Wal-Finate D	HUMAN OTC DRUG LABEL	2	0363-0382	TABLET	60 mg	ORAL	OTC MONOGRAPH FINAL	16 sections